A dynamic Bayesian network (DBN) is a Bayesian network (BN) which relates variables to each other over adjacent time steps. == History == A dynamic Bayesian network (DBN) is often called a "two-timeslice" BN (2TBN) because it says that at any point in time T, the value of a variable can be calculated from the internal regressors and the immediate prior value (time T-1). DBNs were developed by Paul Dagum in the early 1990s at Stanford University's Section on Medical Informatics. Dagum developed DBNs to unify and extend traditional linear state-space models such as Kalman filters, linear and normal forecasting models such as ARMA and simple dependency models such as hidden Markov models into a general probabilistic representation and inference mechanism for arbitrary nonlinear and non-normal time-dependent domains. Today, DBNs are common in robotics, and have shown potential for a wide range of data mining applications. For example, they have been used in speech recognition, digital forensics, protein sequencing, and bioinformatics. DBN is a generalization of hidden Markov models and Kalman filters. DBNs are conceptually related to probabilistic Boolean networks and can, similarly, be used to model dynamical systems at steady-state.
Singularity studies
Singularity studies is an interdisciplinary academic field which examines the idea of technological singularity — the hypothesised point at which artificial intelligence may surpass human intelligence, might be attained by artificial intelligence (AI), robotics, and other technologies and sciences, and its social impacts. In this academic field, the study and research are conducted across a broad array of terrains such as information science, robotics, social informatics, economics, philosophy, and ethics. The primary aim of singularity studies is to gain an integrative understanding of the transformation of social systems occurring in tandem with the explosive evolution of AI and also the changes to be effected by such transformation in the view of humans, ethics, and legal systems. == History == An academic work on technological singurality has appeared in computer science, philosophy, sociology, and law since the early 1990s. Early discussions of an intelligence explosion were popularised by science-fiction writer Vernor Vinge in 1993 and later systematised by futurist Ray Kurzweil. Since the 2010s, universities such as Oxford, Stanford, and Keio have established dedicated programmes, while peer-reviewed journals have begun to publish scenario analyses and policy studies. Ongoing debates question the predictive value of singularity scenarios and warn against a deterministic view of technology. == Characteristics of research == Singularity studies extends beyond mere future predictions and offer an intellectual foundation for proactively designing and creating a desirable future. Principal research themes in this realm include: Ethics of AI; Social implications of technologies; Possibility of harmonious coexistence of humans and AI; Communication with AI; and Redesign of social systems. == Technologists and academics == Vernor Vinge: Propounded the concept of singularity in 1993, making a massive impact on the academic and science-fiction spheres. Ray Kurzweil: Predicted the advent around 2045 of the technological singularity in his 2005 book The Singularity Is Near. Nick Bostrom: Offered philosophical reflections on superintelligence and the risks posed by AI. He is the founding director of the now-dissolved Future of Humanity Institute at the University of Oxford. === Japan === Kento Sasano: A social informatician, AI educator, and inventor. He is the president of the Japan Society of Singularity Studies. == Challenges and outlook == Singularity studies is still evolving as an academic field, and quite a few challenges remain unresolved in regard to the systematization of their theories, research methods, and educational curricula. That said, in this day and age of accelerating technological and societal shifts, interdisciplinary approaches have gained in importance and are drawing much attention in the arenas of scholarly research, intercorporate collaboration, and policy planning.
DARPA Prize Competitions
Over the years, the U.S. Defense Advanced Research Projects Agency (DARPA) has conducted numerous prize competitions to spur innovation. A prize competition allows DARPA to establish an ambitious goal, opening the door to novel approaches from the public that might otherwise appear too risky for experts in a particular field to pursue. == Statutory authorities == In 1999, Congress provided prize competition authority to DARPA in the National Defense Authorization Act for Fiscal Year 2000 (P.L. 106–65), 10 U.S.C. § 4025, formerly 10 U.S.C. §2374a. DARPA also conducts prize competitions under the America COMPETES Act, 15 U.S.C. § 3719. == Recent prize competitions == DARPA Grand Challenge (2004 and 2005) was a prize competition to spur the development of autonomous vehicle technologies. The $1 million prize went unclaimed as no vehicles could complete the challenging desert route from Barstow, CA, to Primm, NV, on March 13, 2004. A year later, on October 8, 2005, the Stanford Racing Team won the $2 million prize during the second competition of the Grand Challenge in the desert Southwest near the California/Nevada state line. DARPA Urban Challenge (2007) required the competitors to build an autonomous vehicle capable of driving in traffic and performing complex maneuvers such as merging, passing, parking, and negotiating intersections. On November 3, 2007, the Carnegie Mellon Team won the $2 million prize, and its vehicle became the first autonomous vehicle that interacted with both manned and unmanned vehicle traffic in an urban environment. DARPA Network Challenge (Red Balloon Challenge) (2009) explored the roles that the Internet and social networking play in solving broad-scope, time-critical problems. On December 5, 2009, the Massachusetts Institute of Technology team won $40,000 by locating the ten moored, eight-foot, red weather balloons at ten places in the United States within seven hours. DARPA Digital Manufacturing Analysis, Correlation and Estimation Challenge (DMACE) (2010) was a three-month contest to showcase the potential of digital manufacturing of advanced materials. The University of California at Santa Barbara team won a $50,000 prize for crushing 180 digitally manufactured (DM) titanium mesh spheres with the most accurate predictive model of the components’ properties. DARPA Shredder Challenge (2011) was to identify and assess potential capabilities and vulnerabilities to sensitive information in the national security community. Participating teams must download the images of the documents shredded into more than 10,000 pieces from the Challenge website, reconstruct the documents, and solve the five puzzles. Of almost 9,000 teams, the San Francisco-based All Your Shreds Are Belong to U.S team won the $50,000 prize. DARPA UAVForge Challenge (2011-2012) aimed to build and test a user-intuitive, backpack-portable unmanned aerial vehicle (UAV) that could quietly fly in and out of critical environments to conduct sustained surveillance for up to three hours. The $100,000 prize was not claimed because none of the 140 teams met the technical matrix. DARPA Cash for Locating & Identifying Quick Response Codes (CLIQR) Quest Challenge (2012) explored the role the Internet and social media played in the timely communication, wide-area team-building, and urgent mobilization required to solve broad scope, time-critical problems. The challenge offered $40,000 to the first individual or team that could locate seven posters appearing in U.S. cities bearing the DARPA logo and a quick response code (QR) within 15 days. No team found and submitted all seven codes. DARPA Fast Adaptable Next-Generation Ground Vehicle (FANG) Challenge (2012-2013) was to use three competitions for the design of an infantry fighting vehicle, culminating in prototypes. In April 2013, DARPA awarded US$1 million to a three-man team during the first competition. DARPA decided not to proceed with the second and third competitions as originally planned and transitioned the technologies to the defense and commercial industry through the Digital Manufacturing and Design Innovation Institute (DMDII). DARPA Spectrum Challenge (2013-2014) sought to demonstrate how a software-defined radio can use a given communication channel in the presence of other users and interfering signals. Three teams emerged as the overall winners, winning a total of $150,000 in prizes. DARPA Chikungunya (CHIKV) Challenge (2014-2015) was a health-related effort to develop the most accurate predictions of CHIKV cases for all Western Hemisphere countries and territories between September 2014 and March 2015. On May 12, 2015, DARPA awarded $500,000 in prizes to the 11 winners of the competition during a scientific review DARPA Robotics Challenge (DRC) (2013-2015) aimed to develop semi-autonomous ground robots that could do "complex tasks in dangerous, degraded, human-engineered environments." A South Korean team won the first prize of $2 million, and two U.S. teams won $1 million and $500,000 as second and third winners. DARPA Cyber Grand Challenge (CGC) (2014 - 2016) was to “create automatic defensive systems capable of reasoning about flaws, formulating patches and deploying them on a network in real time.” The top three winners were awarded prizes of $2 million, $1 million, and $750,000, respectively. DARPA Spectrum Collaboration Challenge (SC2) (2016-2019) aimed to encourage the development of AI-enabled wireless networks to “ensure that the exponentially growing number of military and civilian wireless devices would have full access to the increasingly crowded electromagnetic spectrum.” A team from the University of Florida won the overall top prize of US$2 million at the final SC2 competition. DARPA Subterranean (SubT) Challenge (2017-2021) was to develop robotic technologies to map, navigate, search and exploit complex underground environments. The first-place winners of the system final competition and of the virtual final competition were awarded $2 million and $750,000, respectively, with multiple prizes awarded to the second and third-place winners. DARPA Launch Challenge (2018-2020) was a $12 million satellite launch challenge to demonstrate responsive and flexible space launch capabilities from the small launch providers and was to culminate in two separate launch competitions where the competitors must launch a satellite to low Earth orbit (LEO) within days of each other at different locations in the United States. The competition ended without a winner. DARPA Forecasting Floats in Turbulence (FFT) Challenge (2021) was to spur technologies that could predict the location of sea drifters or floats within 10 days. DARPA awarded $25,000 for first place, with prizes of $15,000 and $10,000 for second place and third place. DARPA Artificial Intelligence Cyber Challenge (AIxCC) (2023–2025) was a two-year challenge and asks competitors to design novel AI systems to secure critical software code on which Americans rely. The total prize money is $29.5 million. In March 2024, the Advanced Research Projects Agency for Health (ARPA-H) partnered with DARPA, contributing an additional $20 million to the competition's prize pool to address software vulnerabilities in medical devices, hospital IT, and biotech equipment. AIxCC collaborates with Google, Microsoft, OpenAI, Anthropic, Linux Foundation, Open Source Security Foundation, Black Hat USA, and DEF CON, all of which provide AIxCC with access to large language models. In August 2024, AIxCC held the semifinal at DEF CON in Las Vegas. DARPA and ARPA-H tested all 42 submissions by running them through various open-source coding projects with deliberately injected vulnerabilities and scored the tools based on their effectiveness in identifying and fixing security flaws. Seven teams, each winning $2 million in the semifinals, competed in the final round of the AIxCC at the August 2025 DEF CON conference. Team Atlanta won first place with a $4 million prize for its cyber reasoning systems, which identified and patched vulnerabilities across 54 million lines of code. DARPA Triage Challenge (2023 – 2026) aims to spur the development of novel physiological features for medical triage, with a total prize money of $7 million. In October 2024, Challenge Event 1 was held in Perry, Georgia, featuring to-scale replicas of disaster sites such as an airplane crash and Hurricane Katrina, and teams competed based on how closely their data aligned with the agency’s official data and how quickly and accurately their autonomous systems could identify individuals most urgently in need of medical care. DARPA concluded the second year of competitions and, in November 2025, named the top performers in systems and data categories, which will advance to the final 2026 competition. The DARPA Lift Challenge (2025-2026) is for participants to design unmanned aerial systems capable of carrying up to four times their own weight, with a minimum payload of 110 pounds. Acco
Generative adversarial network
A generative adversarial network (GAN) is a class of machine learning frameworks and a prominent framework for approaching generative artificial intelligence. The concept was initially developed by Ian Goodfellow and his colleagues in June 2014. In a GAN, two neural networks compete with each other in the form of a zero-sum game, where one agent's gain is another agent's loss. Given a training set, this technique learns to generate new data with the same statistics as the training set. For example, a GAN trained on photographs can generate new photographs that look at least superficially authentic to human observers, having many realistic characteristics. Though originally proposed as a form of generative model for unsupervised learning, GANs have also proved useful for semi-supervised learning, fully supervised learning, and reinforcement learning. The core idea of a GAN is based on the "indirect" training through the discriminator, another neural network that can tell how "realistic" the input seems, which itself is also being updated dynamically. This means that the generator is not trained to minimize the distance to a specific image, but rather to fool the discriminator. This enables the model to learn in an unsupervised manner. GANs are similar to mimicry in evolutionary biology, with an evolutionary arms race between both networks. == Definition == === Mathematical === The original GAN is defined as the following game: Each probability space ( Ω , μ ref ) {\displaystyle (\Omega ,\mu _{\text{ref}})} defines a GAN game. There are 2 players: generator and discriminator. The generator's strategy set is P ( Ω ) {\displaystyle {\mathcal {P}}(\Omega )} , the set of all probability measures μ G {\displaystyle \mu _{G}} on Ω {\displaystyle \Omega } . The discriminator's strategy set is the set of Markov kernels μ D : Ω → P [ 0 , 1 ] {\displaystyle \mu _{D}:\Omega \to {\mathcal {P}}[0,1]} , where P [ 0 , 1 ] {\displaystyle {\mathcal {P}}[0,1]} is the set of probability measures on [ 0 , 1 ] {\displaystyle [0,1]} . The GAN game is a zero-sum game, with objective function L ( μ G , μ D ) := E x ∼ μ ref , y ∼ μ D ( x ) [ ln y ] + E x ∼ μ G , y ∼ μ D ( x ) [ ln ( 1 − y ) ] . {\displaystyle L(\mu _{G},\mu _{D}):=\operatorname {E} _{x\sim \mu _{\text{ref}},y\sim \mu _{D}(x)}[\ln y]+\operatorname {E} _{x\sim \mu _{G},y\sim \mu _{D}(x)}[\ln(1-y)].} The generator aims to minimize the objective, and the discriminator aims to maximize the objective. The generator's task is to approach μ G ≈ μ ref {\displaystyle \mu _{G}\approx \mu _{\text{ref}}} , that is, to match its own output distribution as closely as possible to the reference distribution. The discriminator's task is to output a value close to 1 when the input appears to be from the reference distribution, and to output a value close to 0 when the input looks like it came from the generator distribution. === In practice === The generative network generates candidates while the discriminative network evaluates them. This creates a contest based on data distributions, where the generator learns to map from a latent space to the true data distribution, aiming to produce candidates that the discriminator cannot distinguish from real data. The discriminator's goal is to correctly identify these candidates, but as the generator improves, its task becomes more challenging, increasing the discriminator's error rate. A known dataset serves as the initial training data for the discriminator. Training involves presenting it with samples from the training dataset until it achieves acceptable accuracy. The generator is trained based on whether it succeeds in fooling the discriminator. Typically, the generator is seeded with randomized input that is sampled from a predefined latent space (e.g. a multivariate normal distribution). Thereafter, candidates synthesized by the generator are evaluated by the discriminator. Independent backpropagation procedures are applied to both networks so that the generator produces better samples, while the discriminator becomes more skilled at flagging synthetic samples. When used for image generation, the generator is typically a deconvolutional neural network, and the discriminator is a convolutional neural network. === Relation to other statistical machine learning methods === GANs are implicit generative models, which means that they do not explicitly model the likelihood function nor provide a means for finding the latent variable corresponding to a given sample, unlike alternatives such as flow-based generative model. Compared to fully visible belief networks such as WaveNet and PixelRNN and autoregressive models in general, GANs can generate one complete sample in one pass, rather than multiple passes through the network. Compared to Boltzmann machines and linear ICA, there is no restriction on the type of function used by the network. Since neural networks are universal approximators, GANs are asymptotically consistent. Variational autoencoders might be universal approximators, but it is not proven as of 2017. == Mathematical properties == === Measure-theoretic considerations === This section provides some of the mathematical theory behind these methods. In modern probability theory based on measure theory, a probability space also needs to be equipped with a σ-algebra. As a result, a more rigorous definition of the GAN game would make the following changes:Each probability space ( Ω , B , μ ref ) {\displaystyle (\Omega ,{\mathcal {B}},\mu _{\text{ref}})} defines a GAN game. The generator's strategy set is P ( Ω , B ) {\displaystyle {\mathcal {P}}(\Omega ,{\mathcal {B}})} , the set of all probability measures μ G {\displaystyle \mu _{G}} on the measure-space ( Ω , B ) {\displaystyle (\Omega ,{\mathcal {B}})} . The discriminator's strategy set is the set of Markov kernels μ D : ( Ω , B ) → P ( [ 0 , 1 ] , B ( [ 0 , 1 ] ) ) {\displaystyle \mu _{D}:(\Omega ,{\mathcal {B}})\to {\mathcal {P}}([0,1],{\mathcal {B}}([0,1]))} , where B ( [ 0 , 1 ] ) {\displaystyle {\mathcal {B}}([0,1])} is the Borel σ-algebra on [ 0 , 1 ] {\displaystyle [0,1]} .Since issues of measurability never arise in practice, these will not concern us further. === Choice of the strategy set === In the most generic version of the GAN game described above, the strategy set for the discriminator contains all Markov kernels μ D : Ω → P [ 0 , 1 ] {\displaystyle \mu _{D}:\Omega \to {\mathcal {P}}[0,1]} , and the strategy set for the generator contains arbitrary probability distributions μ G {\displaystyle \mu _{G}} on Ω {\displaystyle \Omega } . However, as shown below, the optimal discriminator strategy against any μ G {\displaystyle \mu _{G}} is deterministic, so there is no loss of generality in restricting the discriminator's strategies to deterministic functions D : Ω → [ 0 , 1 ] {\displaystyle D:\Omega \to [0,1]} . In most applications, D {\displaystyle D} is a deep neural network function. As for the generator, while μ G {\displaystyle \mu _{G}} could theoretically be any computable probability distribution, in practice, it is usually implemented as a pushforward: μ G = μ Z ∘ G − 1 {\displaystyle \mu _{G}=\mu _{Z}\circ G^{-1}} . That is, start with a random variable z ∼ μ Z {\displaystyle z\sim \mu _{Z}} , where μ Z {\displaystyle \mu _{Z}} is a probability distribution that is easy to compute (such as the uniform distribution, or the Gaussian distribution), then define a function G : Ω Z → Ω {\displaystyle G:\Omega _{Z}\to \Omega } . Then the distribution μ G {\displaystyle \mu _{G}} is the distribution of G ( z ) {\displaystyle G(z)} . Consequently, the generator's strategy is usually defined as just G {\displaystyle G} , leaving z ∼ μ Z {\displaystyle z\sim \mu _{Z}} implicit. In this formalism, the GAN game objective is L ( G , D ) := E x ∼ μ ref [ ln D ( x ) ] + E z ∼ μ Z [ ln ( 1 − D ( G ( z ) ) ) ] . {\displaystyle L(G,D):=\operatorname {E} _{x\sim \mu _{\text{ref}}}[\ln D(x)]+\operatorname {E} _{z\sim \mu _{Z}}[\ln(1-D(G(z)))].} === Generative reparametrization === The GAN architecture has two main components. One is casting optimization into a game, of form min G max D L ( G , D ) {\displaystyle \min _{G}\max _{D}L(G,D)} , which is different from the usual kind of optimization, of form min θ L ( θ ) {\displaystyle \min _{\theta }L(\theta )} . The other is the decomposition of μ G {\displaystyle \mu _{G}} into μ Z ∘ G − 1 {\displaystyle \mu _{Z}\circ G^{-1}} , which can be understood as a reparametrization trick. To see its significance, one must compare GAN with previous methods for learning generative models, which were plagued with "intractable probabilistic computations that arise in maximum likelihood estimation and related strategies". At the same time, Kingma and Welling and Rezende et al. developed the same idea of reparametrization into a general stochastic backpropagation method. Among its first applications was the variational autoencoder. === Move order and st
Clinical decision support system
A clinical decision support system (CDSS) is a form of health information technology that provides clinicians, staff, patients, or other individuals with knowledge and person-specific information to enhance decision-making in clinical workflows. CDSS tools include alerts and reminders, clinical guidelines, condition-specific order sets, patient data summaries, diagnostic support, and context-aware reference information. They often leverage artificial intelligence to analyze clinical data and help improve care quality and safety. CDSSs constitute a major topic in artificial intelligence in medicine. == Characteristics == A clinical decision support system is an active knowledge system that uses variables of patient data to produce advice regarding health care. This implies that a CDSS is simply a decision support system focused on using knowledge management. === Purpose === The main purpose of modern CDSS is to assist clinicians at the point of care. This means that clinicians interact with a CDSS to help to analyze and reach a diagnosis based on patient data for different diseases. In the early days, CDSSs were conceived to make decisions for the clinician in a literal manner. The clinician would input the information and wait for the CDSS to output the "right" choice, and the clinician would simply act on that output. However, the modern methodology of using CDSSs to assist means that the clinician interacts with the CDSS, utilizing both their knowledge and the CDSS's, better to analyse the patient's data than either a human or a CDSS could do on their own. Typically, a CDSS makes suggestions for the clinician to review, and the clinician is expected to pick out useful information from the presented results and discount erroneous CDSS suggestions. The two main types of CDSS are knowledge-based systems and non-knowledge-based (machine learning–based) systems: An example of how a clinician might use a clinical decision support system is a diagnosis decision support system (DDSS). DDSS requests some of the patient's data and, in response, proposes a set of possible diagnoses. The physician then takes the output of the DDSS and determines which diagnoses are likely and which are not, and, if necessary, orders further tests to narrow down the diagnosis. Another example of a CDSS would be a case-based reasoning (CBR) system. A CBR system might use previous case data to help determine the appropriate amount of beams and the optimal beam angles for use in radiotherapy for brain cancer patients; medical physicists and oncologists would then review the recommended treatment plan to determine its viability. Another important classification of a CDSS is based on the timing of its use. Physicians use these systems at the point of care to help them as they are dealing with a patient, with the timing of use being either pre-diagnosis, during diagnosis, or post-diagnosis. Pre-diagnosis CDSS systems help the physician prepare the diagnoses. CDSSs help review and filter the physician's preliminary diagnostic choices to improve outcomes. Post-diagnosis CDSS systems are used to mine data to derive connections between patients and their past medical history and clinical research to predict future events. Early speculation that AI-based decision support would replace clinicians in common tasks has largely given way to a consensus around assistive models, in which AI augments rather than supplants clinical judgment. Contemporary deep learning-based systems, unlike earlier rule-based tools, can be trained directly on clinical data without manual rule authoring and integrated into electronic health record workflows at the point of care. Another approach, used by the National Health Service in England, is to use a CDSS to triage medical conditions out of hours by suggesting a suitable next step to the patient (e.g. call an ambulance, or see a general practitioner on the next working day). The suggestion, which may be disregarded by either the patient or the phone operative if common sense or caution suggests otherwise, is based on the known information and an implicit conclusion about what the worst-case diagnosis is likely to be; it is not always revealed to the patient because it might well be incorrect and is not based on a medically-trained person's opinion - it is only used for initial triage purposes. === Knowledge-based === Most CDSSs consist of three parts: the knowledge base, an inference engine, and a mechanism to communicate. The knowledge base contains the rules and associations of compiled data which most often take the form of IF-THEN rules. If this was a system for determining drug interactions, then a rule might be that IF drug X is taken AND drug Y is taken THEN alert the user. Using another interface, an advanced user could edit the knowledge base to keep it up to date with new drugs. The inference engine combines the rules from the knowledge base with the patient's data. The communication mechanism allows the system to show the results to the user as well as have input into the system. An expression language such as GELLO or CQL (Clinical Quality Language) is needed for expressing knowledge artefacts in a computable manner. For example: if a patient has diabetes mellitus, and if the last haemoglobin A1c test result was less than 7%, recommend re-testing if it has been over six months, but if the last test result was greater than or equal to 7%, then recommend re-testing if it has been over three months. The current focus of the HL7 CDS WG is to build on the Clinical Quality Language (CQL). The U.S. Centers for Medicare & Medicaid Services (CMS) has announced that it plans to use CQL for the specification of Electronic Clinical Quality Measures (eCQMs). === Non-knowledge-based === CDSSs which do not use a knowledge base use a form of artificial intelligence called machine learning, which allow computers to learn from past experiences and/or find patterns in clinical data. This eliminates the need for writing rules and expert input. However, since systems based on machine learning cannot explain the reasons for their conclusions, most clinicians do not use them directly for diagnoses, reliability and accountability reasons. Nevertheless, they can be useful as post-diagnostic systems, for suggesting patterns for clinicians to look into in more depth. As of 2012, three types of non-knowledge-based systems are support-vector machines, artificial neural networks and genetic algorithms. Artificial neural networks use nodes and weighted connections between them to analyse the patterns found in patient data to derive associations between symptoms and a diagnosis. Genetic algorithms are based on simplified evolutionary processes using directed selection to achieve optimal CDSS results. The selection algorithms evaluate components of random sets of solutions to a problem. The solutions that come out on top are then recombined and mutated and run through the process again. This happens over and over until the proper solution is discovered. They are functionally similar to neural networks in that they are also "black boxes" that attempt to derive knowledge from patient data. Non-knowledge-based networks often focus on a narrow list of symptoms, such as symptoms for a single disease, as opposed to the knowledge-based approach, which covers the diagnosis of many diseases. An example of a non-knowledge-based CDSS is a web server developed using a support vector machine for the prediction of gestational diabetes in Ireland. == Regulations == === History, United States === The IOM had published a report in 1999, To Err is Human, which focused on the patient safety crisis in the United States, pointing to the incredibly high number of deaths. This statistic attracted great attention to the quality of patient care. The Institute of Medicine (IOM) promoted the usage of health information technology, including clinical decision support systems, to advance the quality of patient care. With the enactment of the American Recovery and Reinvestment Act of 2009 (ARRA), there was a push for widespread adoption of health information technology through the Health Information Technology for Economic and Clinical Health Act (HITECH). Through these initiatives, more hospitals and clinics were integrating electronic medical records (EMRs) and computerized physician order entry (CPOE) within their health information processing and storage. Despite the absence of laws, the CDSS vendors would almost certainly be viewed as having a legal duty of care to both the patients who may adversely be affected due to CDSS usage and the clinicians who may use the technology for patient care. However, duties of care legal regulations are not explicitly defined yet. With the enactment of the HITECH Act included in the ARRA, encouraging the adoption of health IT, more detailed case laws for CDSS and EMRs were still being defined by the Office of National Coordinator for Health Informati
Tail latency
Tail latency is a term used to describe the high-percentile response times seen in a system. This is usually measured at the 95th, 99th, or 99.9th percentile, not the average latency. In distributed systems, cloud computing, and large-scale web services, even a small number of slow requests can make the user experience and system performance much worse. Tail latency often happens because of things like resource contention, network variability, garbage collection pauses, and hardware heterogeneity. A major problem in system design is managing tail latency, because lowering average latency doesn't always make the worst-case performance better. To lessen its effects, people often use techniques like request hedging, replication, load balancing, and adaptive timeouts. In latency-sensitive applications like search engines, financial systems, and real-time services, where service-level objectives (SLOs) are often based on high-percentile latencies, it is especially important to understand and improve tail latency.
The MANIAC
The MANIAC is a 2023 novel by Chilean author Benjamín Labatut, written in English. It is a fictionalised biography of polymath John von Neumann, whom Labatut calls "the smartest human being of the 20th century". The book focuses on von Neumann, but is also about physicist Paul Ehrenfest, the history of artificial intelligence, and Lee Sedol's Go match against AlphaGo. The book received mostly positive reviews from critics. == Background == John von Neumann was a Jewish Hungarian-born polymath who was a prodigy from an early childhood. Von Neumann worked in multiple fields of science, theoretical (mathematical foundations of quantum mechanics, game theory, cellular automata) and applied (nuclear weapons research during the Manhattan Project in World War II, computer architecture later named after him, and many other subjects). Labatut calls him "the smartest human being of the 20th century". The title of the book is derived from an early computer based on von Neumann architecture, built after the war at Los Alamos laboratory, called MANIAC I. Benjamín Labatut is a Chilean author known for his 2020 book When We Cease to Understand the World, a collection of fictionalised stories about famous scientists that received positive reviews and was translated into multiple languages from Spanish. The MANIAC is Labatut's first book written in English. In an interview, Labatut said he prefers to write in English: English is my preferred form of thought. ... English is the language I do most if not all my reading it. And it is a far better language than Spanish, in so many ways. Writing "clean" prose in Spanish is almost impossible, because so many of its sounds clash. Borges said that he found English "a far finer language than Spanish" because it's both Germanic and Latin; because of its wonderful vocabulary ("Regal is not exactly the same thing as saying kingly," he explained); because of its physicality; and because you can do almost anything with verbs and prepositions. Labatut was inspired to write The MANIAC by George Dyson's book Turing's Cathedral. == Synopsis == The book has three chapters. The first chapter, "Paul or the Discovery of the Irrational", written in the third person, is about physicist Paul Ehrenfest. The chapter opens with Ehrenfest shooting dead his son Vassily, who suffered from Down syndrome, and then himself. It then recounts Ehrenfest's life story, describing his relationships with his wife Tatyana, his mistress Nelly Meyjes, and his eminent physicist colleagues. It chronicles his descent into despair and depression over his marriage's disintegration, the advent of quantum mechanics, and the direction Europe was heading in with the Nazi Party's rise to power in Germany, looping back to the initial scene of the chapter. The second chapter, "John or the Mad Dreams of Reason", is about John von Neumann, and is written as a series of interviews of his family members, wives, friends, and colleagues, each in a distinctive voice. It is divided into three parts. Part I, "The Limits of Logic", is about his early life, as told by von Neumann's childhood friend Eugene Wigner, mother Margrit Kann, brother Nicholas von Neumann, first wife Mariette Kövesi, and scientists Theodore von Karman, George Polya, and Gábor Szegő. It climaxes with von Neumann's participation in David Hilbert's program to create a logical basis for mathematics based on a consistent set of axioms, a quest ultimately scuppered by Kurt Gödel. Part II, "The Delicate Balance of Terror", discusses von Neumann's role in the Manhattan Project (as told by Richard Feynman); his development of game theory and the doctrine of mutual assured destruction (MAD) (as told by Oskar Morgenstern); and his creation of the MANIAC I computer and the von Neumann architecture (as told by Julian Bigelow). In Part III, "Ghosts in the Machine", Sydney Brenner discusses von Neumann's contributions to biology, his theoretical work on self-replicating and self-repairing machines, and his vision of Von Neumann probes exploring the universe. Nils Aall Barricelli talks about his ideas of digital life and his disagreements with von Neumann. Von Neumann's wife Klára Dán, daughter Marina, and Wigner talk about his final years, personal life, and death. The third chapter, "Lee or The Delusions of Artificial Intelligence", is about Lee Sedol's Go match against AlphaGo. The narrative reverts to the third person. The chapter also tells the story of Demis Hassabis, a chess prodigy in childhood who decided to work on artificial intelligence and founded DeepMind, the company behind AlphaGo. The way is pointed to the future, as artificial intelligence's growing capabilities outpace the human mind. The book ends with Lee Sedol's retirement from Go, and new version of DeepMind's program, AlphaZero, that did not train on human games but nevertheless became the strongest player in Go, chess, and Shogi. == Reception == The book received mostly positive reviews. In his review for The New York Times Tom McCarthy noted the ambiguity of genre: "At its best, as in the stunning opening sequence reconstructing the murder-suicide of the physicist Paul Ehrenfest and his disabled son, or in the final section's gripping account of a computer defeating the world's best human Go player, you just throw up your hands and think, Who cares what discourse label we assign this stuff? It's great." Becca Rothfeld of the Washington Post praised the book, writing that it is "Labatut's latest virtuosic effort, at once a historical novel and a philosophical foray": "The MANIAC is a work of dark, eerie and singular beauty." She noted that the book "can also be difficult to read" because of its unusual narrative structure: "The book is narrated by a cluttered polyphony of characters, among them both of von Neumann's wives and a number of his teachers and colleagues. ... Like von Neumann, The MANIAC strives to adopt the impartial standpoint of the universe." Killian Fox of The Guardian sees the book as "darkly fascinating novel", and notes Labatut's "impressive dexterity, unpicking complex ideas in long, elegant sentences that propel us forward at speed (this is his first book written in English). Even in the more feverish passages, when yet another great mind succumbs to madness, haunted by the spectres they've helped unleash on the world, he feels in full control of his material." Sam Byers of The Guardian praises the book and the author's style: "The opening chapter of Benjamín Labatut's second novel is such a perfect distillation of his technique that it could serve as a manifesto." and "Readers ... will recognise the sense of breathlessness his best writing can evoke. Seemingly loosened from the laws of physics they describe, his sentences range freely through time and space, connecting not only characters and events, but the delicate tissue of intellectual history, often with a lightness of touch that belies their underlying complexity." He writes on the narrative structure: "Through a cascade of staccato chapters, an ensemble of narrators offer their piecemeal insights." Byers adds that "a brilliant novel is not quite what we end up with" and sees the problem in the "diffusion": "Labatut simply spreads himself too thin. Too many years in too few pages; too many voices with far too little to distinguish them. Initially intriguing, the bite-size monologues quickly come to feel inadequate." Some reviewers did not see the book as a biography. In an essay for the Cleveland Review of Books, Ben Cosman juxtaposes the book with Christopher Nolan's biopic Oppenheimer, and writes that it "follows the development of artificial intelligence—first as an idea at the beginning of the twentieth century, and then as a practicality at the beginning of the twenty-first—through the lives of three men who faced it." He also compared the book's structure to "witness testimony". Another reviewer called the book "perfect for anyone thirsting for more nuclear anxiety after watching Oppenheimer". Garrett Biggs of the Chicago Review of Books writes of the book's style: "Labatut writes about scientists the way Roberto Bolaño writes about poets. They are near mythical figures, captured at the corner of the novel's eye. They become historical in the most fraught sense of the term: subject to rumor and speculation and, eventually, the novel's form inflates their personas into something so large they can only be understood as narrative, never known in any objective capacity." Biggs criticises the last chapter: "the story of artificial intelligence has yet to be written. And so when Labatut's narration editorializes about artificial intelligence as 'a future that inspires hope and horror,' The MANIAC disassembles as a novel and starts to sound like a stale thinkpiece. AlphaGo might represent the first glimmer of a true artificial intelligence, as Labatut suggests. It also could one day be considered nothing more than a souped-up cousin to IBM's DeepBlue.