Rejoyn is a prescription-only digital therapeutic smartphone app approved by the US FDA for the treatment of major depressive disorder (MDD) in adults ages 22 and up. It is prescribed in conjunction with standard antidepressant medication and professional guidance and support. Rejoyn was developed by Click Therapeutics and Otsuka America Pharmaceutical Inc., and gained FDA clearance as a "medical device" on March 30th, 2024. The smartphone app helps patients with depression using exercises based on cognitive behavioral therapy (CBT) along with timed notifications to keep the patient engaged and in treatment. Randomized controlled trials showed that the Rejoyn app was more effective at relieving depression symptoms compared to a "sham app", a placebo app that required similar effort but was not intended to be helpful. Dr. John Torous, MD, MBI,[a] a psychiatrist at the Beth Israel Deaconess Medical Center in Boston, said that the app seems to pose minimal risks, and is an important step forward in unlocking the power of smartphones in treating psychiatric disorders. Some experts have signaled that the claims should be taken with caution, since the app was "tested only in a narrow subset of patients." and its benefits are "not statistically significant," according to the study’s primary outcome."
Picture Prowler
Picture Prowler was an early piece of photo management software developed around and meant to show off Xing Technology's JPEG image decompression library during the early 1990s. Little known today, it featured thumbnail based picture management, printing, etc. The primary developer was Ray Bunnage from compression / decompression libraries developed by Howard Gordon and Chris Eddy.
Bernhard Schölkopf
Bernhard Schölkopf (born 20 February 1968) is a German computer scientist known for his work in machine learning, especially on kernel methods and causality. He is a director at the Max Planck Institute for Intelligent Systems in Tübingen, Germany, where he heads the Department of Empirical Inference. He is also an affiliated professor at ETH Zürich, honorary professor at the University of Tübingen and Technische Universität Berlin, and chairman of the European Laboratory for Learning and Intelligent Systems (ELLIS). == Research == === Kernel methods === Schölkopf developed SVM methods achieving world record performance on the MNIST pattern recognition benchmark at the time. With the introduction of kernel PCA, Schölkopf and coauthors argued that SVMs are a special case of a much larger class of methods, and all algorithms that can be expressed in terms of dot products can be generalized to a nonlinear setting by means of what is known as reproducing kernels. Another significant observation was that the data on which the kernel is defined need not be vectorial, as long as the kernel Gram matrix is positive definite. Both insights together led to the foundation of the field of kernel methods, encompassing SVMs and many other algorithms. Kernel methods are now textbook knowledge and one of the major machine learning paradigms in research and applications. Developing kernel PCA, Schölkopf extended it to extract invariant features and to design invariant kernels and showed how to view other major dimensionality reduction methods such as LLE and Isomap as special cases. In further work with Alex Smola and others, he extended the SVM method to regression and classification with pre-specified sparsity and quantile/support estimation. He proved a representer theorem implying that SVMs, kernel PCA, and most other kernel algorithms, regularized by a norm in a reproducing kernel Hilbert space, have solutions taking the form of kernel expansions on the training data, thus reducing an infinite dimensional optimization problem to a finite dimensional one. He co-developed kernel embeddings of distributions methods to represent probability distributions in Hilbert Spaces, with links to Fraunhofer diffraction as well as applications to independence testing. === Causality === Starting in 2005, Schölkopf turned his attention to causal inference. Causal mechanisms in the world give rise to statistical dependencies as epiphenomena, but only the latter are exploited by popular machine learning algorithms. Knowledge about causal structures and mechanisms is useful by letting us predict not only future data coming from the same source, but also the effect of interventions in a system, and by facilitating transfer of detected regularities to new situations. Schölkopf and co-workers addressed (and in certain settings solved) the problem of causal discovery for the two-variable setting and connected causality to Kolmogorov complexity. Around 2010, Schölkopf began to explore how to use causality for machine learning, exploiting assumptions of independence of mechanisms and invariance. His early work on causal learning was exposed to a wider machine learning audience during his Posner lecture at NeurIPS 2011, as well as in a keynote talk at ICML 2017. He assayed how to exploit underlying causal structures in order to make machine learning methods more robust with respect to distribution shifts and systematic errors, the latter leading to the discovery of a number of new exoplanets including K2-18b, which was subsequently found to contain water vapour in its atmosphere, a first for an exoplanet in the habitable zone. == Education and employment == Schölkopf studied mathematics, physics, and philosophy in Tübingen and London. He was supported by the Studienstiftung and won the Lionel Cooper Memorial Prize for the best M.Sc. in Mathematics at the University of London. He completed a Diplom in Physics, and then moved to Bell Labs in New Jersey, where he worked with Vladimir Vapnik, who became co-adviser of his PhD thesis at TU Berlin (with Stefan Jähnichen). His thesis, defended in 1997, won the annual award of the German Informatics Association. In 2001, following positions in Berlin, Cambridge and New York, he founded the Department for Empirical Inference at the Max Planck Institute for Biological Cybernetics, which grew into a leading center for research in machine learning. In 2011, he became founding director at the Max Planck Institute for Intelligent Systems. With Alex Smola, Schölkopf co-founded the series of Machine Learning Summer Schools. He also co-founded a Cambridge-Tübingen PhD Programme and the Max Planck-ETH Center for Learning Systems. In 2016, he co-founded the Cyber Valley research consortium. He participated in the IEEE Global Initiative on "Ethically Aligned Design". Schölkopf is co-editor-in-Chief of the Journal of Machine Learning Research, a journal he helped found, being part of a mass resignation of the editorial board of Machine Learning (journal). He is among the world’s most cited computer scientists. Alumni of his lab include Ulrike von Luxburg, Carl Rasmussen, Matthias Hein, Arthur Gretton, Gunnar Rätsch, Matthias Bethge, Stefanie Jegelka, Jason Weston, Olivier Bousquet, Olivier Chapelle, Joaquin Quinonero-Candela, and Sebastian Nowozin. As of late 2023, Schölkopf is also a scientific advisor to French research group Kyutai which is being funded by Xavier Niel, Rodolphe Saadé, Eric Schmidt, and others. == Awards and recognition == Schölkopf’s awards include the Royal Society Milner Award and, shared with Isabelle Guyon and Vladimir Vapnik, the BBVA Foundation Frontiers of Knowledge Award in the Information and Communication Technologies category. He was the first scientist working in Europe to receive this award. He was elected a Fellow of the Royal Society in 2026.
Trevor Hastie
Trevor John Hastie (born 27 June 1953) is an American statistician and computer scientist. He is currently serving as the John A. Overdeck Professor of Mathematical Sciences and Professor of Statistics at Stanford University. Hastie is known for his contributions to applied statistics, especially in the field of machine learning, data mining, and bioinformatics. He has authored several popular books in statistical learning, including The Elements of Statistical Learning: Data Mining, Inference, and Prediction. Hastie has been listed as an ISI Highly Cited Author in Mathematics by the ISI Web of Knowledge. He also contributed to the development of S. == Education and career == Hastie was born on 27 June 1953 in South Africa. He received his B.S. in statistics from the Rhodes University in 1976 and master's degree from University of Cape Town in 1979. Hastie joined the doctoral program at Stanford University in 1980 and received his Ph.D. in 1984 under the supervision of Werner Stuetzle. His dissertation was "Principal Curves and Surfaces". Hastie began his professional career in 1977 with the South African Medical Research Council. After receiving his master's degree in 1979, he spent a year interning at the London School of Hygiene & Tropical Medicine, the Johnson Space Center in Houston, and the Biomath department at Oxford University. After receiving his doctoral degree from Stanford, Hastie returned to South Africa to work with his former employer South African Medical Research Council. He returned to United States in 1986 and joined the AT&T Bell Laboratories in Murray Hill, New Jersey and remained there for nine years. Working with John Chambers, he co-directed the development of the S programming language. He joined Stanford University in 1994 as Associate Professor in Statistics and Biostatistics. He was promoted to full Professor in 1999. During the period 2006–2009, he was the chair of the Department of Statistics at Stanford University. In 2013 he was named the John A. Overdeck Professor of Mathematical Sciences. == Awards and honors == Hastie is a Fellow of the Royal Statistical Society since 1979. He is also an elected Fellow of several professional and scholarly societies, including the Institute of Mathematical Statistics, the American Statistical Association, and the South African Statistical Society. He is a recipient of 'Myrto Lefkopolou Distinguished Lectureship' award of Biostatistics Department at the Harvard School of Public Health. In 2018, he was elected a member of the National Academy of Sciences. In 2019 Hastie became a foreign member of the Royal Netherlands Academy of Arts and Sciences. Hastie was named for the C.R. and Bhargavi Rao Prize in 2025. Hastie and Hui Zou received the 2025 Founders of Statistics prize for their elastic net paper. == Publications == Hastie is a prolific author of scientific works on numerous topics in applied statistics, including statistical learning, data mining, statistical computing, and bioinformatics. He along with his collaborators has authored about 125 scientific articles. Many of Hastie's scientific articles were coauthored by his longtime collaborator, Robert Tibshirani. Hastie has been listed as an ISI Highly Cited Author in Mathematics by the ISI Web of Knowledge. He has coauthored the following books: T. Hastie and R. Tibshirani, Generalized Additive Models, Chapman and Hall, 1990. J. Chambers and T. Hastie, Statistical Models in S, Wadsworth/Brooks Cole, 1991. T. Hastie, R. Tibshirani, and J. Friedman, The Elements of Statistical Learning: Prediction, Inference and Data Mining, Second Edition, Springer Verlag, 2009 (available for free from the author's website). G. James, D. Witten, T. Hastie, R. Tibshirani, An Introduction to Statistical Learning with Applications in R, Springer Verlag, 2013 (available for free from the co-author's website). T. Hastie, R. Tibshirani, M. Wainwright, Statistical Learning with Sparsity: the Lasso and Generalizations, CRC Press, 2015 (available for free from the author's website). Bradley Efron; Trevor Hastie (2016). Computer Age Statistical Inference. Cambridge University Press. ISBN 9781107149892.
Timnit Gebru
Timnit W. Gebru (Amharic and Tigrinya: ትምኒት ገብሩ; 1982/1983) is an Eritrean Ethiopian-born computer scientist who works in the fields of artificial intelligence (AI), algorithmic bias and data mining. She is a co-founder of Black in AI, an advocacy group that has pushed for more Black roles in AI development and research. She is the founder of the Distributed Artificial Intelligence Research Institute (DAIR). In December 2020, public controversy erupted over the circumstances surrounding Gebru's departure from Google, where she was technical co-lead of the Ethical Artificial Intelligence Team. Gebru had coauthored a paper on the risks of large language models (LLMs) acting as stochastic parrots, and submitted it for publication. According to Jeff Dean, head of Google AI, the paper was submitted without waiting for Google's internal review, which then asserted that it ignored too much relevant research. Google management requested that Gebru either withdraw the paper or remove the names of all the authors employed by Google. Gebru requested the identity and feedback of every reviewer, and stated that if Google refused, she would talk to her manager about "a last date". Google terminated her employment immediately, stating that they were accepting her resignation. Gebru maintained that she had not formally offered to resign, and only threatened to. Gebru has been widely recognized for her expertise in the ethics of artificial intelligence. She was named one of the World's 50 Greatest Leaders by Fortune and one of Nature's ten people who shaped science in 2021, and in 2022, one of Time's most influential people. == Early life and education == Gebru was raised in Addis Ababa, Ethiopia. Her father, an electrical engineer with a Doctor of Philosophy (PhD), died when she was five years old, and she was raised by her mother, an economist. Both her parents are from Eritrea. When Gebru was 15, during the Eritrean–Ethiopian War, she fled Ethiopia after some of her family were deported to Eritrea and compelled to fight in the war. She was initially denied a U.S. visa and briefly lived in Ireland, but she eventually received political asylum in the U.S., an experience she said was "miserable". Gebru settled in Somerville, Massachusetts to attend high school, where she says she immediately started to experience racial discrimination, with some teachers refusing to allow her to take certain Advanced Placement courses, despite being a high-achiever. After she completed high school, an encounter with the police set Gebru on a course toward a focus on ethics in technology. A friend of hers, a Black woman, was assaulted in a bar, and Gebru called the police to report it. She says that instead of filing the assault report, her friend was arrested and remanded to a cell. Gebru called it a pivotal moment and a "blatant example of systemic racism." In 2001, Gebru was accepted at Stanford University. There, she earned her Bachelor of Science and Master of Science degrees in electrical engineering and her PhD in computer vision in 2017. Gebru was advised during her PhD program by Fei-Fei Li. During the 2008 United States presidential election, Gebru canvassed in support of Barack Obama. Gebru presented her doctoral research at the 2017 LDV Capital Vision Summit competition, where computer vision scientists present their work to members of industry and venture capitalists. Gebru won the competition, starting a series of collaborations with other entrepreneurs and investors. Both during her PhD program in 2016 and in 2018, Gebru returned to Ethiopia with Jelani Nelson's programming campaign, AddisCoder. While working on her PhD, Gebru authored a paper that was never published about her concern over the future of AI. She wrote of the dangers of the lack of diversity in the field, centered on her experiences with the police and on a ProPublica investigation into predictive policing, which revealed a projection of human biases in machine learning. In the paper, she scathed the "boy's club culture", reflecting on her experiences at conference gatherings of drunken male attendees sexually harassing her, and criticized the hero worship of the field's celebrities. == Career == === 2004–2013: Software development at Apple === Gebru joined Apple as an intern while at Stanford, working in their hardware division making circuitry for audio components, and was offered a full-time position the following year. Of her work as an audio engineer, her manager told Wired she was "fearless", and well-liked by her colleagues. During her tenure at Apple, Gebru became more interested in building software, namely computer vision that could detect human figures. She went on to develop signal processing algorithms for the first iPad. At the time, she said she did not consider the potential use for surveillance, saying "I just found it technically interesting." Long after leaving the company, during the #AppleToo movement in the summer of 2021, which was led by Apple engineer Cher Scarlett, who consulted with Gebru, Gebru revealed she experienced "so many egregious things" and "always wondered how they manage[d] to get out of the spotlight." She said that accountability at Apple was long overdue, and warned they could not continue to fly under the radar for much longer. Gebru also criticized the way the media covers Apple and other tech giants, saying that the press helps shield such companies from public scrutiny. === 2013–2017: Research at Stanford and Microsoft === In 2013, Gebru joined Fei-Fei Li's lab at Stanford, where she combined deep learning with Google Street View to estimate the demographics of United States neighbourhoods, showing that socioeconomic attributes such as voting patterns, income, race, and education can be inferred from observations of cars. In 2015, Gebru attended the field's top conference, Neural Information Processing Systems (NIPS), in Montreal, Canada. Out of 3,700 attendees, she noted she was one of only a few Black researchers. When she attended again the following year, she kept a tally and noted that there were only five Black men and that she was the only Black woman out of 8,500 delegates. Together with her colleague Rediet Abebe, Gebru founded Black in AI, a community of Black researchers working in artificial intelligence that aims to increase the presence, visibility, and well-being of Black professionals and leaders within the field. In the summer of 2017, Gebru joined Microsoft as a postdoctoral researcher in the Fairness, Accountability, Transparency, and Ethics in AI (FATE) lab. In 2017, Gebru spoke at the Fairness and Transparency conference, where MIT Technology Review interviewed her about biases that exist in AI systems and how adding diversity in AI teams can fix that issue. In her interview with Jackie Snow, Snow asked Gebru, "How does the lack of diversity distort artificial intelligence and specifically computer vision?" and Gebru pointed out that there are biases that exist in the software developers. While at Microsoft, Gebru co-authored a research paper called Gender Shades, which became the namesake of a project of a broader Massachusetts Institute of Technology project led by co-author Joy Buolamwini. The pair investigated facial recognition software, finding that in one particular implementation Black women were 35% less likely to be recognized than White men. === 2018–2020: Artificial intelligence ethics at Google === Gebru joined Google in 2018, where she co-led a team on the ethics of artificial intelligence with Margaret Mitchell. She studied the implications of artificial intelligence, looking to improve the ability of technology to do social good. In 2019, Gebru and other artificial intelligence researchers "signed a letter calling on Amazon to stop selling its facial-recognition technology to law enforcement agencies because it is biased against women and people of color", citing a study that was conducted by MIT researchers showing that Amazon's facial recognition system had more trouble identifying darker-skinned females than any other technology company's facial recognition software. In a New York Times interview, Gebru has further expressed that she believes facial recognition is too dangerous to be used for law enforcement and security purposes at present. === Exit from Google === In 2020 Gebru and five co-authors wrote a paper titled "On the Dangers of Stochastic Parrots: Can Language Models Be Too Big? 🦜". The paper examined risks of very large language models, including their environmental footprint, financial costs, the inscrutability of large models, the potential for LLMs to display prejudice against certain groups, the inability of LLMs to understand the language they process, and the use of LLMs to spread disinformation. In December 2020, her employment with Google ended after Google management asked her to either withdraw the paper before publication, or remove the names of all the Google employees from
Point distribution model
The point distribution model is a model for representing the mean geometry of a shape and some statistical modes of geometric variation inferred from a training set of shapes. == Background == The point distribution model concept has been developed by Cootes, Taylor et al. and became a standard in computer vision for the statistical study of shape and for segmentation of medical images where shape priors really help interpretation of noisy and low-contrasted pixels/voxels. The latter point leads to active shape models (ASM) and active appearance models (AAM). Point distribution models rely on landmark points. A landmark is an annotating point posed by an anatomist onto a given locus for every shape instance across the training set population. For instance, the same landmark will designate the tip of the index finger in a training set of 2D hands outlines. Principal component analysis (PCA), for instance, is a relevant tool for studying correlations of movement between groups of landmarks among the training set population. Typically, it might detect that all the landmarks located along the same finger move exactly together across the training set examples showing different finger spacing for a flat-posed hands collection. == Details == First, a set of training images are manually landmarked with enough corresponding landmarks to sufficiently approximate the geometry of the original shapes. These landmarks are aligned using the generalized procrustes analysis, which minimizes the least squared error between the points. k {\displaystyle k} aligned landmarks in two dimensions are given as X = ( x 1 , y 1 , … , x k , y k ) {\displaystyle \mathbf {X} =(x_{1},y_{1},\ldots ,x_{k},y_{k})} . It's important to note that each landmark i ∈ { 1 , … k } {\displaystyle i\in \lbrace 1,\ldots k\rbrace } should represent the same anatomical location. For example, landmark #3, ( x 3 , y 3 ) {\displaystyle (x_{3},y_{3})} might represent the tip of the ring finger across all training images. Now the shape outlines are reduced to sequences of k {\displaystyle k} landmarks, so that a given training shape is defined as the vector X ∈ R 2 k {\displaystyle \mathbf {X} \in \mathbb {R} ^{2k}} . Assuming the scattering is gaussian in this space, PCA is used to compute normalized eigenvectors and eigenvalues of the covariance matrix across all training shapes. The matrix of the top d {\displaystyle d} eigenvectors is given as P ∈ R 2 k × d {\displaystyle \mathbf {P} \in \mathbb {R} ^{2k\times d}} , and each eigenvector describes a principal mode of variation along the set. Finally, a linear combination of the eigenvectors is used to define a new shape X ′ {\displaystyle \mathbf {X} '} , mathematically defined as: X ′ = X ¯ + P b {\displaystyle \mathbf {X} '={\overline {\mathbf {X} }}+\mathbf {P} \mathbf {b} } where X ¯ {\displaystyle {\overline {\mathbf {X} }}} is defined as the mean shape across all training images, and b {\displaystyle \mathbf {b} } is a vector of scaling values for each principal component. Therefore, by modifying the variable b {\displaystyle \mathbf {b} } an infinite number of shapes can be defined. To ensure that the new shapes are all within the variation seen in the training set, it is common to only allow each element of b {\displaystyle \mathbf {b} } to be within ± {\displaystyle \pm } 3 standard deviations, where the standard deviation of a given principal component is defined as the square root of its corresponding eigenvalue. PDM's can be extended to any arbitrary number of dimensions, but are typically used in 2D image and 3D volume applications (where each landmark point is R 2 {\displaystyle \mathbb {R} ^{2}} or R 3 {\displaystyle \mathbb {R} ^{3}} ). == Discussion == An eigenvector, interpreted in euclidean space, can be seen as a sequence of k {\displaystyle k} euclidean vectors associated to corresponding landmark and designating a compound move for the whole shape. Global nonlinear variation is usually well handled provided nonlinear variation is kept to a reasonable level. Typically, a twisting nematode worm is used as an example in the teaching of kernel PCA-based methods. Due to the PCA properties: eigenvectors are mutually orthogonal, form a basis of the training set cloud in the shape space, and cross at the 0 in this space, which represents the mean shape. Also, PCA is a traditional way of fitting a closed ellipsoid to a Gaussian cloud of points (whatever their dimension): this suggests the concept of bounded variation. The idea behind PDMs is that eigenvectors can be linearly combined to create an infinity of new shape instances that will 'look like' the one in the training set. The coefficients are bounded alike the values of the corresponding eigenvalues, so as to ensure the generated 2n/3n-dimensional dot will remain into the hyper-ellipsoidal allowed domain—allowable shape domain (ASD).
Keyword (linguistics)
In corpus linguistics a key word is a word which occurs in a text more often than we would expect to occur by chance alone. Key words are calculated by carrying out a statistical test (e.g., loglinear or chi-squared) which compares the word frequencies in a text against their expected frequencies derived in a much larger corpus, which acts as a reference for general language use. Keyness is then the quality a word or phrase has of being "key" in its context. Combinations of nouns with parts of speech that human readers would not likely notice, such as prepositions, time adverbs, and pronouns can be a relevant part of keyness. Even separate pronouns can constitute keywords. Compare this with collocation, the quality linking two words or phrases usually assumed to be within a given span of each other. Keyness is a textual feature, not a language feature (so a word has keyness in a certain textual context but may well not have keyness in other contexts, whereas a node and collocate are often found together in texts of the same genre so collocation is to a considerable extent a language phenomenon). The set of keywords found in a given text share keyness, they are co-key. Words typically found in the same texts as a key word are called associates. == Sociological aspects == In politics, sociology and critical discourse analysis, the key reference for keywords was Raymond Williams (1976), but Williams was resolutely Marxist, and Critical Discourse Analysis has tended to perpetuate this political meaning of the term: keywords are part of ideologies and studying them is part of social criticism. Cultural studies has tended to develop along similar lines. This stands in stark contrast to present day linguistics which is wary of political analysis, and has tended to aspire to non-political objectivity. The development of technology, new techniques and methodology relating to massive corpora have all consolidated this trend. === Translatability === There are, however, numerous political dimensions that come into play when keywords are studied in relation to cultures, societies and their histories. The Lublin Ethnolinguistics School studies Polish and European keywords in this fashion. Anna Wierzbicka (1997), probably the best known cultural linguist writing in English today, studies languages as parts of cultures evolving in society and history. And it becomes impossible to ignore politics when keywords migrate from one culture to another. Underhill and Gianninoto demonstrate the way political terms like, "citizen" and "individual" are integrated into the Chinese worldview over the course of the 19th and 20th century. They argue that this is part of a complex readjustment of conceptual clusters related to "the people". Keywords like "citizen" generate various translations in Chinese, and are part of an ongoing adaptation to global concepts of individual rights and responsibilities. Understanding keywords in this light becomes crucial for understanding how the politics of China evolves as Communism emerges and as the free market and citizens' rights develop. Underhill and Gianninoto argue that this is part of the complex ways ideological worldviews interact with the language as an ongoing means of perceiving and understanding the world. Barbara Cassin studies keywords in a more traditional manner, striving to define the words specific to individual cultures, in order to demonstrate that many of our keywords are partially "untranslatable" into their "equivalents. The Greeks may need four words to cover all the meanings English-speakers have in mind when speaking of "love". Similarly, the French find that "liberté" suffices, while English-speakers attribute different associations to "liberty" and "freedom": "freedom of speech" or "freedom of movement", but "the Statue of Liberty". == Software-assisted identification == Keywords are identified by software that compares a word-list of the text with a word-list based on a larger reference corpus. Software such as e.g. WordSmith, lists keywords and phrases and allows plotting their occurrence as they appear in texts.