In neuroscience and computer science, synaptic weight refers to the strength or amplitude of a connection between two nodes, corresponding in biology to the amount of influence the firing of one neuron has on another. The term is typically used in artificial and biological neural network research. == Computation == In a computational neural network, a vector or set of inputs x {\displaystyle {\textbf {x}}} and outputs y {\displaystyle {\textbf {y}}} , or pre- and post-synaptic neurons respectively, are interconnected with synaptic weights represented by the matrix w {\displaystyle w} , where for a linear neuron y j = ∑ i w i j x i or y = w x {\displaystyle y_{j}=\sum _{i}w_{ij}x_{i}~~{\textrm {or}}~~{\textbf {y}}=w{\textbf {x}}} . where the rows of the synaptic matrix represent the vector of synaptic weights for the output indexed by j {\displaystyle j} . The synaptic weight is changed by using a learning rule, the most basic of which is Hebb's rule, which is usually stated in biological terms as Neurons that fire together, wire together. Computationally, this means that if a large signal from one of the input neurons results in a large signal from one of the output neurons, then the synaptic weight between those two neurons will increase. The rule is unstable, however, and is typically modified using such variations as Oja's rule, radial basis functions or the backpropagation algorithm. == Biology == For biological networks, the effect of synaptic weights is not as simple as for linear neurons or Hebbian learning. However, biophysical models such as BCM theory have seen some success in mathematically describing these networks. In the mammalian central nervous system, signal transmission is carried out by interconnected networks of nerve cells, or neurons. For the basic pyramidal neuron, the input signal is carried by the axon, which releases neurotransmitter chemicals into the synapse which is picked up by the dendrites of the next neuron, which can then generate an action potential which is analogous to the output signal in the computational case. The synaptic weight in this process is determined by several variable factors: How well the input signal propagates through the axon (see myelination), The amount of neurotransmitter released into the synapse and the amount that can be absorbed in the following cell (determined by the number of AMPA and NMDA receptors on the cell membrane and the amount of intracellular calcium and other ions), The number of such connections made by the axon to the dendrites, How well the signal propagates and integrates in the postsynaptic cell. The changes in synaptic weight that occur is known as synaptic plasticity, and the process behind long-term changes (long-term potentiation and depression) is still poorly understood. Hebb's original learning rule was originally applied to biological systems, but has had to undergo many modifications as a number of theoretical and experimental problems came to light.
Graph cut optimization
Graph cut optimization is a combinatorial optimization method applicable to a family of functions of discrete variables, named after the concept of cut in the theory of flow networks. Thanks to the max-flow min-cut theorem, determining the minimum cut over a graph representing a flow network is equivalent to computing the maximum flow over the network. Given a pseudo-Boolean function f {\displaystyle f} , if it is possible to construct a flow network with positive weights such that each cut C {\displaystyle C} of the network can be mapped to an assignment of variables x {\displaystyle \mathbf {x} } to f {\displaystyle f} (and vice versa), and the cost of C {\displaystyle C} equals f ( x ) {\displaystyle f(\mathbf {x} )} (up to an additive constant) then it is possible to find the global optimum of f {\displaystyle f} in polynomial time by computing a minimum cut of the graph. The mapping between cuts and variable assignments is done by representing each variable with one node in the graph and, given a cut, each variable will have a value of 0 if the corresponding node belongs to the component connected to the source, or 1 if it belong to the component connected to the sink. Not all pseudo-Boolean functions can be represented by a flow network, and in the general case the global optimization problem is NP-hard. There exist sufficient conditions to characterise families of functions that can be optimised through graph cuts, such as submodular quadratic functions. Graph cut optimization can be extended to functions of discrete variables with a finite number of values, that can be approached with iterative algorithms with strong optimality properties, computing one graph cut at each iteration. Graph cut optimization is an important tool for inference over graphical models such as Markov random fields or conditional random fields, and it has applications in computer vision problems such as image segmentation, denoising, registration and stereo matching. == Representability == A pseudo-Boolean function f : { 0 , 1 } n → R {\displaystyle f:\{0,1\}^{n}\to \mathbb {R} } is said to be representable if there exists a graph G = ( V , E ) {\displaystyle G=(V,E)} with non-negative weights and with source and sink nodes s {\displaystyle s} and t {\displaystyle t} respectively, and there exists a set of nodes V 0 = { v 1 , … , v n } ⊂ V − { s , t } {\displaystyle V_{0}=\{v_{1},\dots ,v_{n}\}\subset V-\{s,t\}} such that, for each tuple of values ( x 1 , … , x n ) ∈ { 0 , 1 } n {\displaystyle (x_{1},\dots ,x_{n})\in \{0,1\}^{n}} assigned to the variables, f ( x 1 , … , x n ) {\displaystyle f(x_{1},\dots ,x_{n})} equals (up to a constant) the value of the flow determined by a minimum cut C = ( S , T ) {\displaystyle C=(S,T)} of the graph G {\displaystyle G} such that v i ∈ S {\displaystyle v_{i}\in S} if x i = 0 {\displaystyle x_{i}=0} and v i ∈ T {\displaystyle v_{i}\in T} if x i = 1 {\displaystyle x_{i}=1} . It is possible to classify pseudo-Boolean functions according to their order, determined by the maximum number of variables contributing to each single term. All first order functions, where each term depends upon at most one variable, are always representable. Quadratic functions f ( x ) = w 0 + ∑ i w i ( x i ) + ∑ i < j w i j ( x i , x j ) . {\displaystyle f(\mathbf {x} )=w_{0}+\sum _{i}w_{i}(x_{i})+\sum _{i
Taxonomic database
A taxonomic database is a database created to hold information on biological taxa – for example groups of organisms organized by species name or other taxonomic identifier – for efficient data management and information retrieval. Taxonomic databases are routinely used for the automated construction of biological checklists such as floras and faunas, both for print publication and online; to underpin the operation of web-based species information systems; as a part of biological collection management (for example in museums and herbaria); as well as providing, in some cases, the taxon management component of broader science or biology information systems. They are also a fundamental contribution to the discipline of biodiversity informatics. == Goals == Taxonomic databases digitize scientific biodiversity data and provide access to taxonomic data for research. Taxonomic databases vary in breadth of the groups of taxa and geographical space they seek to include, for example: beetles in a defined region, mammals globally, or all described taxa in the tree of life. A taxonomic database may incorporate organism identifiers (scientific name, author, and – for zoological taxa – year of original publication), synonyms, taxonomic opinions, literature sources or citations, illustrations or photographs, and biological attributes for each taxon (such as geographic distribution, ecology, descriptive information, threatened or vulnerable status, etc.). Some databases, such as the Global Biodiversity Information Facility(GBIF) database and the Barcode of Life Data System, store the DNA barcode of a taxon if one exists (also called the Barcode Index Number (BIN) which may be assigned, for example, by the International Barcode of Life project (iBOL) or UNITE, a database for fungal DNA barcoding). A taxonomic database aims to accurately model the characteristics of interest that are relevant to the organisms which are in scope for the intended coverage and usage of the system. For example, databases of fungi, algae, bryophytes and vascular plants ("higher plants") encode conventions from the International Code of Botanical Nomenclature while their counterparts for animals and most protists encode equivalent rules from the International Code of Zoological Nomenclature. Modelling the relevant taxonomic hierarchy for any taxon is a natural fit with the relational model employed in almost all database systems. Scientific consensus is not reached for all taxon groups, and new species continue to be described; therefore, another goal of taxonomic databases is to aid in resolving conflicts of scientific opinion and unify taxonomy. == History == Possibly the earliest documented management of taxonomic information in computerised form comprised the taxonomic coding system developed by Richard Swartz et al. at the Virginia Institute of Marine Science for the Biota of Chesapeake Bay and described in a published report in 1972. This work led directly or indirectly to other projects with greater profile including the NODC Taxonomic Code system which went through 8 versions before being discontinued in 1996, to be subsumed and transformed into the still current Integrated Taxonomic Information System (ITIS). A number of other taxonomic databases specializing in particular groups of organisms that appeared in the 1970s through to the present jointly contribute to the Species 2000 project, which since 2001 has been partnering with ITIS to produce a combined product, the Catalogue of Life. While the Catalogue of Life currently concentrates on assembling basic name information as a global species checklist, numerous other taxonomic database projects such as Fauna Europaea, the Australian Faunal Directory, and more supply rich ancillary information including descriptions, illustrations, maps, and more. Many taxonomic database projects are currently listed at the TDWG "Biodiversity Information Projects of the World" site. == Issues == The representation of taxonomic information in machine-encodable form raises a number of issues not encountered in other domains, such as variant ways to cite the same species or other taxon name, the same name used for multiple taxa (homonyms), multiple non-current names for the same taxon (synonyms), changes in name and taxon concept definition through time, and more. Non-standardized categories and metadata in taxonomic databases hampers the ability for researchers to analyze the data. One forum that has promoted discussion and possible solutions to these and related problems since 1985 is the Biodiversity Information Standards (TDWG), originally called the Taxonomic Database Working Group. While online databases have great benefits (for example, increased access to taxonomic information), they also have issues such as data integrity risks due to on- and off-line versions and continuous updates, technical access issues due to server or internet outage, and differing capacities for complex queries to extract taxonomic data into lists. As the quantity of information in online taxonomic databases rapidly expands, data aggregation, and the integration and alignment of non-standardized data across databases, is a big challenge in taxonomy and biodiversity informatics.
Weak stability boundary
Weak stability boundary (WSB), including low-energy transfer, is a concept introduced by Edward Belbruno in 1987. The concept explained how a spacecraft could change orbits using very little fuel. Weak stability boundary is defined for the three-body problem. This problem considers the motion of a particle P of negligible mass moving with respect to two larger bodies, P1, P2, modeled as point masses, where these bodies move in circular or elliptical orbits with respect to each other, and P2 is smaller than P1. The force between the three bodies is the classical Newtonian gravitational force. For example, P1 is the Earth, P2 is the Moon and P is a spacecraft; or P1 is the Sun, P2 is Jupiter and P is a comet, etc. This model is called the restricted three-body problem. The weak stability boundary defines a region about P2 where P is temporarily captured. This region is in position-velocity space. Capture means that the Kepler energy between P and P2 is negative. This is also called weak capture. == Background == This boundary was defined for the first time by Edward Belbruno of Princeton University in 1987. He described a Low-energy transfer which would allow a spacecraft to change orbits using very little fuel. It was for motion about Moon (P2) with P1 = Earth. It is defined algorithmically by monitoring cycling motion of P about the Moon and finding the region where cycling motion transitions between stable and unstable after one cycle. Stable motion means P can completely cycle about the Moon for one cycle relative to a reference section, starting in weak capture. P needs to return to the reference section with negative Kepler energy. Otherwise, the motion is called unstable, where P does not return to the reference section within one cycle or if it returns, it has non-negative Kepler energy. The set of all transition points about the Moon comprises the weak stability boundary, W. The motion of P is sensitive or chaotic as it moves about the Moon within W. A mathematical proof that the motion within W is chaotic was given in 2004. This is accomplished by showing that the set W about an arbitrary body P2 in the restricted three-body problem contains a hyperbolic invariant set of fractional dimension consisting of the infinitely many intersections Hyperbolic manifolds. The weak stability boundary was originally referred to as the fuzzy boundary. This term was used since the transition between capture and escape defined in the algorithm is not well defined and limited by the numerical accuracy. This defines a "fuzzy" location for the transition points. It is also due the inherent chaos in the motion of P near the transition points. It can be thought of as a fuzzy chaos region. As is described in an article in Discover magazine, the WSB can be roughly viewed as the fuzzy edge of a region, referred to as a gravity well, about a body (the Moon), where its force of gravity becomes small enough to be dominated by force of gravity of another body (the Earth) and the motion there is chaotic. A much more general algorithm defining W was given in 2007. It defines W relative to n-cycles, where n = 1,2,3,..., yielding boundaries of order n. This gives a much more complex region consisting of the union of all the weak stability boundaries of order n. This definition was explored further in 2010. The results suggested that W consists, in part, of the hyperbolic network of invariant manifolds associated to the Lyapunov orbits about the L1, L2 Lagrange points near P2. The explicit determination of the set W about P2 = Jupiter, where P1 is the Sun, is described in "Computation of Weak Stability Boundaries: Sun-Jupiter Case". It turns out that a weak stability region can also be defined relative to the larger mass point, P1. A proof of the existence of the weak stability boundary about P1 was given in 2012, but a different definition is used. The chaos of the motion is analytically proven in "Geometry of Weak Stability Boundaries". The boundary is studied in "Applicability and Dynamical Characterization of the Associated Sets of the Algorithmic Weak Stability Boundary in the Lunar Sphere of Influence". == Applications == There are a number of important applications for the weak stability boundary (WSB). Since the WSB defines a region of temporary capture, it can be used, for example, to find transfer trajectories from the Earth to the Moon that arrive at the Moon within the WSB region in weak capture, which is called ballistic capture for a spacecraft. No fuel is required for capture in this case. This was numerically demonstrated in 1987. This is the first reference for ballistic capture for spacecraft and definition of the weak stability boundary. The boundary was operationally demonstrated to exist in 1991 when it was used to find a ballistic capture transfer to the Moon for Japan's Hiten spacecraft. Other missions have used the same transfer type as Hiten, including Grail, Capstone, Danuri, Hakuto-R Mission 1 and SLIM. The WSB for Mars is studied in "Earth-Mars Transfers with Ballistic Capture" and ballistic capture transfers to Mars are computed. The BepiColombo mission of ESA should achieve ballistic capture at the WSB of Mercury in November 2026. The WSB region can be used in the field of Astrophysics. It can be defined for stars within open star clusters. This is done in "Chaotic Exchange of Solid Material Between Planetary Systems: Implications for the Lithopanspermia Hypothesis" to analyze the capture of solid material that may have arrived on the Earth early in the age of the Solar System to study the validity of the lithopanspermia hypothesis. Numerical explorations of trajectories for P starting in the WSB region about P2 show that after the particle P escapes P2 at the end of weak capture, it moves about the primary body, P1, in a near resonant orbit, in resonance with P2 about P1. This property was used to study comets that move in orbits about the Sun in orbital resonance with Jupiter, which change resonance orbits by becoming weakly captured by Jupiter. An example of such a comet is 39P/Oterma. This property of change of resonance of orbits about P1 when P is weakly captured by the WSB of P2 has an interesting application to the field of quantum mechanics to the motion of an electron about the proton in a hydrogen atom. The transition motion of an electron about the proton between different energy states described by the Schrödinger equation is shown to be equivalent to the change of resonance of P about P1 via weak capture by P2 for a family of transitioning resonance orbits. This gives a classical model using chaotic dynamics with Newtonian gravity for the motion of an electron.
Semantic integration
Semantic integration is the process of interrelating information from diverse sources, for example calendars and to do lists, email archives, presence information (physical, psychological, and social), documents of all sorts, contacts (including social graphs), search results, and advertising and marketing relevance derived from them. In this regard, semantics focuses on the organization of and action upon information by acting as an intermediary between heterogeneous data sources, which may conflict not only by structure but also context or value. == Applications and methods == In enterprise application integration (EAI), semantic integration can facilitate or even automate the communication between computer systems using metadata publishing. Metadata publishing potentially offers the ability to automatically link ontologies. One approach to (semi-)automated ontology mapping requires the definition of a semantic distance or its inverse, semantic similarity and appropriate rules. Other approaches include so-called lexical methods, as well as methodologies that rely on exploiting the structures of the ontologies. For explicitly stating similarity/equality, there exist special properties or relationships in most ontology languages. OWL, for example has "owl:equivalentClass", "owl:equivalentProperty" and "owl:sameAs". Eventually system designs may see the advent of composable architectures where published semantic-based interfaces are joined together to enable new and meaningful capabilities. These could predominately be described by means of design-time declarative specifications, that could ultimately be rendered and executed at run-time. Semantic integration can also be used to facilitate design-time activities of interface design and mapping. In this model, semantics are only explicitly applied to design and the run-time systems work at the syntax level. This "early semantic binding" approach can improve overall system performance while retaining the benefits of semantic driven design. == Semantic integration situations == From the industry use case, it has been observed that the semantic mappings were performed only within the scope of the ontology class or the datatype property. These identified semantic integrations are (1) integration of ontology class instances into another ontology class without any constraint, (2) integration of selected instances in one ontology class into another ontology class by the range constraint of the property value and (3) integration of ontology class instances into another ontology class with the value transformation of the instance property. Each of them requires a particular mapping relationship, which is respectively: (1) equivalent or subsumption mapping relationship, (2) conditional mapping relationship that constraints the value of property (data range) and (3) transformation mapping relationship that transforms the value of property (unit transformation). Each identified mapping relationship can be defined as either (1) direct mapping type, (2) data range mapping type or (3) unit transformation mapping type. == KG vs. RDB approaches == In the case of integrating supplemental data source, KG(Knowledge graph) formally represents the meaning involved in information by describing concepts, relationships between things, and categories of things. These embedded semantics with the data offer significant advantages such as reasoning over data and dealing with heterogeneous data sources. The rules can be applied on KG more efficiently using graph query. For example, the graph query does the data inference through the connected relations, instead of repeated full search of the tables in relational database. KG facilitates the integration of new heterogeneous data by just adding new relationships between existing information and new entities. This facilitation is emphasized for the integration with existing popular linked open data source such as Wikidata.org. SQL query is tightly coupled and rigidly constrained by datatype within the specific database and can join tables and extract data from tables, and the result is generally a table, and a query can join tables by any columns which match by datatype. SPARQL query is the standard query language and protocol for Linked Open Data on the web and loosely coupled with the database so that it facilitates the reusability and can extract data through the relations free from the datatype, and not only extract but also generate additional knowledge graph with more sophisticated operations(logic: transitive/symmetric/inverseOf/functional). The inference based query (query on the existing asserted facts without the generation of new facts by logic) can be fast comparing to the reasoning based query (query on the existing plus the generated/discovered facts based on logic). The information integration of heterogeneous data sources in traditional database is intricate, which requires the redesign of the database table such as changing the structure and/or addition of new data. In the case of semantic query, SPARQL query reflects the relationships between entities in a way that aligned with human's understanding of the domain, so the semantic intention of the query can be seen on the query itself. Unlike SPARQL, SQL query, which reflects the specific structure of the database and derived from matching the relevant primary and foreign keys of tables, loses the semantics of the query by missing the relationships between entities. Below is the example that compares SPARQL and SQL queries for medications that treats "TB of vertebra". SELECT ?medication WHERE { ?diagnosis a example:Diagnosis . ?diagnosis example:name “TB of vertebra” . ?medication example:canTreat ?diagnosis . } SELECT DRUG.medID FROM DIAGNOSIS, DRUG, DRUG_DIAGNOSIS WHERE DIAGNOSIS.diagnosisID=DRUG_DIAGNOSIS.diagnosisID AND DRUG.medID=DRUG_DIAGNOSIS.medID AND DIAGNOSIS.name=”TB of vertebra” == Examples == The Pacific Symposium on Biocomputing has been a venue for the popularization of the ontology mapping task in the biomedical domain, and a number of papers on the subject can be found in its proceedings.
Flok (company)
Flok (formerly Loyalblocks) was an American tech startup based in New York City that provides marketing services such as chatbots/AI, customer loyalty programs, mobile apps and CRM services to local businesses. In January 2017, the company was acquired by Wix.com. Around March 2017, Flok ceased regular communication. At some point in 2019 Flok communicated to its customers that it would shut down in March 2020. == Background == Flok was founded in 2011 by Ido Gaver and Eran Kirshenboim and has offices in Tel Aviv, Israel. In May 2013, Flok secured a $9 million Series A Round from General Catalyst Partners with participation from Founder Collective and existing investor Gemini Israel Ventures. In total, Flok has raised over $18 million in venture capital in three rounds. In May 2014, Flok announced a self-service loyalty platform for SMBs to build their own programs with beacon integration. At that time, approximately 40,000 businesses were using the service. In 2016, Flok released a turnkey chatbot service for local businesses, and was featured in AdWeek for developing the first weed bot chatbot for a California cannabis business. == Services == Flok offered an eponymous customer-facing app, that consumers use to receive rewards and deals from partner businesses, and a Flok business app for merchants to manage the platform.
Query language
A query language, also known as data query language or database query language (DQL), is a computer language used to make queries in databases and information systems. In database systems, query languages rely on strict theory to retrieve information. A well known example is the Structured Query Language (SQL). == Types == Broadly, query languages can be classified according to whether they are database query languages or information retrieval query languages. The difference is that a database query language attempts to give factual answers to factual questions, while an information retrieval query language attempts to find documents containing information that is relevant to an area of inquiry. Other types of query languages include: Full-text. The simplest query language is treating all terms as bag of words that are to be matched with the postings in the inverted index and where subsequently ranking models are applied to retrieve the most relevant documents. Only tokens are defined in the CFG. Web search engines often use this approach. Boolean. A query language that also supports the use of the Boolean operators AND, OR, NOT. Structured. A language that supports searching within (a combination of) fields when a document is structured and has been indexed using its document structure. Natural language. A query language that supports natural language by parsing the natural language query to a form that can be best used to retrieve relevant documents, for example with Question answering systems or conversational search. == Examples == Attempto Controlled English is a query language that is also a controlled natural language. AQL is a query language for the ArangoDB native multi-model database system. .QL is a proprietary object-oriented query language for querying relational databases; successor of Datalog. CodeQL is the analysis engine used by developers to automate security checks, and by security researchers to perform variant analysis on GitHub. Contextual Query Language (CQL) a formal language for representing queries to information retrieval systems such as web indexes or bibliographic catalogues. Cypher is a query language for the Neo4j graph database. DMX is a query language for data mining models. Datalog is a query language for deductive databases. F-logic is a declarative object-oriented language for deductive databases and knowledge representation. FQL enables you to use a SQL-style interface to query the data exposed by the Graph API. It provides advanced features not available in the Graph API. Gellish English is a language that can be used for queries in Gellish English Databases, for dialogues (requests and responses) as well as for information modeling and knowledge modeling. Gremlin is an Apache Software Foundation graph traversal language for OLTP and OLAP graph systems. GraphQL is a data query language developed by Facebook as an alternate to REST and ad-hoc webservice architectures. HTSQL is a query language that translates HTTP queries to SQL. ISBL is a query language for PRTV, one of the earliest relational database management systems. Jaql is a functional data processing and query language most commonly used for JSON query processing. JPQL is a query language defined as part of Jakarta Persistence (used in Java applications to make queries to a relational DB using entity objects instead of DB tables). jq is a functional programming language often used for processing queries against one or more JSON documents, including very large ones. JSONiq is a declarative query language designed for collections of JSON documents. KQL (Kusto Query Language), a query language by Microsoft used in Azure Data Explorer LDAP is an application protocol for querying and modifying directory services running over TCP/IP. LogiQL is a variant of Datalog and is the query language for the LogicBlox system. M Formula language, a mashup query language used in Microsoft's Power Query. MQL is a cheminformatics query language for a substructure search allowing beside nominal properties also numerical properties. MDX is a query language for OLAP databases. N1QL is a Couchbase's query language finding data in Couchbase Servers. Object Query Language OCL (Object Constraint Language). Despite its name, OCL is also an object query language and an OMG standard. OPath, intended for use in querying WinFS Stores. Poliqarp Query Language is a special query language designed to analyze annotated text. Used in the Poliqarp search engine. PQL is a special-purpose programming language for managing process models based on information about scenarios that these models describe. PRQL PRQL (Pipelined Relational Query Language) is a modern language for transforming data. Consists of a curated set of orthogonal transformations, which are combined together to form a pipeline. PTQL based on relational queries over program traces, allowing programmers to write expressive, declarative queries about program behavior. QUEL is a relational database access language, similar in most ways to SQL. RDQL is a RDF query language. SMARTS is the cheminformatics standard for a substructure search. SPARQL is a query language for RDF graphs. SQL is a well-known query language and data manipulation language for relational databases. XQuery is a query language for XML data sources. XPath is a declarative language for navigating XML documents. YQL is an SQL-like query language created by Yahoo!. Search engine query languages, e.g., as used by Google. or Bing