John Michael Jumper (born 1 January 1985) is an American chemist and computer scientist. Jumper and Demis Hassabis were awarded the 2024 Nobel Prize in Chemistry for protein structure prediction. As of 2025 Jumper serves as director at Google DeepMind. Jumper and his colleagues created AlphaFold, an artificial intelligence (AI) model to predict protein structures from their amino acid sequence with high accuracy. The AlphaFold team had released 214 million protein structures as of January 2024. The scientific journal Nature included Jumper as one of the ten "people who mattered" in science in their annual listing of Nature's 10 in 2021. == Education == Jumper graduated from Pulaski Academy in 2003. He received a Bachelor of Science with majors in physics and mathematics from Vanderbilt University in 2007, a Master of Philosophy in theoretical condensed matter physics from the University of Cambridge where he was a student of St Edmund's College, Cambridge in 2010 on a Marshall Scholarship, a Master of Science in theoretical chemistry from the University of Chicago in 2012, and a Doctor of Philosophy in theoretical chemistry from the University of Chicago in 2017. His doctoral advisors at the University of Chicago were Tobin R. Sosnick and Karl Freed. == Career and research == Jumper's research investigates algorithms for protein structure prediction. === AlphaFold === AlphaFold is a deep learning algorithm developed by Jumper and his team at DeepMind, a research lab acquired by Google's parent company Alphabet Inc. It is an artificial intelligence program which performs predictions of protein structure. === Awards and honors === In November 2020, AlphaFold was named the winner of the 14th Critical Assessment of Structure Prediction (CASP) competition. This international competition benchmarks algorithms to determine which one can best predict the 3D structure of proteins. AlphaFold won the competition, outperforming other algorithms scoring above 90 for around two-thirds of the proteins in CASP's global distance test (GDT), a test that measures the degree to which a computational program predicted structure is similar to the lab experiment determined structure, with 100 being a complete match, within the distance cutoff used for calculating GDT. In 2021, Jumper was awarded the BBVA Foundation Frontiers of Knowledge Award in the category "Biology and Biomedicine". In 2022 Jumper received the Wiley Prize in Biomedical Sciences and for 2023 the Breakthrough Prize in Life Sciences for developing AlphaFold, which accurately predicts the structure of a protein. In 2023 he was awarded the Canada Gairdner International Award and the Albert Lasker Award for Basic Medical Research. In 2024, Jumper and Demis Hassabis shared half of the Nobel Prize in Chemistry for their protein folding predictions, the other half went to David Baker for computational protein design. In 2025, Jumper received the Golden Plate Award of the American Academy of Achievement and the Marshall Medal of the Marshall Aid Commemoration Commission. He was elected a Fellow of the Royal Society (FRS) that same year. In 2026, he was elected a member of the National Academy of Engineering.
Microsoft Clipchamp
Microsoft Clipchamp is a freemium video editing tool developed by Australian company Clipchamp Pty Ltd., a subsidiary of Microsoft. It is a web-based, non-linear editing software that allows users to import, edit, and export audiovisual material in a web browser window. The application is designed to be easy to use for beginners. Clipchamp has offices in Australia, the Philippines, Germany, and the United States. According to figures published by the company, at the beginning of 2021, it had more than 14 million users worldwide. In September 2021, Clipchamp Pty Ltd. was acquired by Microsoft. It has since been offered in a personal version through a Microsoft account and in a business or education version through a work or school account that is built on OneDrive and SharePoint. == Features == Microsoft Clipchamp has multiple features that allow further creativity and accessibility. Since July 2023, users can drag and drop files from their computer, OneDrive, and SharePoint (images, sound & video files) into a list of all media uploaded or inserted. Users can insert media into the video timeline as many times as they want. Users can replace an image, sound, or video clip with another by dragging and dropping it over the target. There is also a Gap Remover tool that removes gaps in the video. Videos can be trimmed, along with timings that can be edited. The user can crop videos and images, too. Text can be added anywhere on the screen, and can be in many fonts, and the size can be changed, too. Specific text color can be selected using presets or an HSV picker, and specific Text Styles (bold, medium, italics, normal) can be selected. The aspect ratio can also be selected, including 16:9, 9:16, 1:1, 4:5, 2:3, and 21:9. Clipchamp also supports numerous effects and transitions for videos and images. The user can export videos in 480p, 720p, and 1080p for free. Exporting GIFs are possible, while the video has to be 15 seconds or less. Microsoft Clipchamp uses a hybrid model of desktop and online application. In the personal version of Clipchamp (on Windows and in a web browser), video processing is all done locally on the computer and mobile phones, but the app itself runs online as a browser-based web app. This is done by uploading and saving project data and information like file names online but not the associated media files themselves. In the work version of Clipchamp, which is a part of Microsoft 365, media files are still processed locally but are automatically backed up to the user's OneDrive or SharePoint work or school account so that it can be accessed anywhere. This version also has integration with other Microsoft productivity services like Microsoft Teams and Microsoft Stream. == History == Clipchamp Pty Ltd. was founded as a startup company by Alexander Dreiling (current CEO), Dave Hewitt, Tobias Raub and Soeren Balko, in Brisbane, Australia, in 2013. In an interview given to SmartCompany, Dreiling commented that at first, the company was "trying to build an enormous, distributed supercomputer". Among the first software developed by the company's team was a tool for video compression and conversion. 2014 saw the official launch of the first version of the free, audiovisual browser-based software on the Clipchamp platform. When the supercomputer project ground to a halt, the team decided to keep going with the video programming technology, which was, in the words of Dreiling, "a tool that worked on Chromebooks". In June 2016, Clipchamp was valued at 1.1 million dollars, according to the Wall Street Journal. In the same month, the second version of Clipchamp was launched internationally. By 2018, the firm had amassed 6.5 million users, attracting investors such as Steve Baxter, who invested one million dollars. In 2020, Clipchamp set up a base in Seattle, USA, after achieving capital of 13.2 million dollars, from alliances made with investment funds such as Transition Level Investments, Tola Capital, and TEN13, among others. In February 2021, Clipchamp published on its website that it has 14 million users worldwide, registered in 250 countries and territories. At that time, the company announced that it had an audiovisual library of 800,000 files. On September 7, 2021, Microsoft announced the acquisition of Clipchamp. In a press release, they expressed their interest in learning more about the video content creation market. Johnson Winter Slattery advised Microsoft on its acquisition. Clipchamp was integrated as part of Windows 11 beginning on March 9, 2022, as part of Insider Preview Build 22572.
Manifold hypothesis
The manifold hypothesis posits that many high-dimensional data sets that occur in the real world actually lie along low-dimensional latent manifolds inside that high-dimensional space. As a consequence of the manifold hypothesis, many data sets that appear to initially require many variables to describe, can actually be described by a comparatively small number of variables, linked to the local coordinate system of the underlying manifold. It is suggested that this principle underpins the effectiveness of machine learning algorithms in describing high-dimensional data sets by considering a few common features. The manifold hypothesis is related to the effectiveness of nonlinear dimensionality reduction techniques in machine learning. Many techniques of dimensional reduction make the assumption that data lies along a low-dimensional submanifold, such as manifold sculpting, manifold alignment, and manifold regularization. The major implications of this hypothesis is that Machine learning models only have to fit relatively simple, low-dimensional, highly structured subspaces within their potential input space (latent manifolds). Within one of these manifolds, it's always possible to interpolate between two inputs, that is to say, morph one into another via a continuous path along which all points fall on the manifold. The ability to interpolate between samples is the key to generalization in deep learning. == The information geometry of statistical manifolds == An empirically-motivated approach to the manifold hypothesis focuses on its correspondence with an effective theory for manifold learning under the assumption that robust machine learning requires encoding the dataset of interest using methods for data compression. This perspective gradually emerged using the tools of information geometry thanks to the coordinated effort of scientists working on the efficient coding hypothesis, predictive coding and variational Bayesian methods. The argument for reasoning about the information geometry on the latent space of distributions rests upon the existence and uniqueness of the Fisher information metric. In this general setting, we are trying to find a stochastic embedding of a statistical manifold. From the perspective of dynamical systems, in the big data regime this manifold generally exhibits certain properties such as homeostasis: We can sample large amounts of data from the underlying generative process. Machine Learning experiments are reproducible, so the statistics of the generating process exhibit stationarity. In a sense made precise by theoretical neuroscientists working on the free energy principle, the statistical manifold in question possesses a Markov blanket.
Discovery system (artificial intelligence)
A discovery system is an artificial intelligence system that attempts to discover new scientific concepts or laws. The aim of discovery systems is to automate scientific data analysis and the scientific discovery process. Ideally, an artificial intelligence system should be able to search systematically through the space of all possible hypotheses and yield the hypothesis - or set of equally likely hypotheses - that best describes the complex patterns in data. During the era known as the second AI summer (approximately 1978–1987), various systems akin to the era's dominant expert systems were developed to tackle the problem of extracting scientific hypotheses from data, with or without interacting with a human scientist. These systems included Autoclass, Automated Mathematician, Eurisko, which aimed at general-purpose hypothesis discovery, and more specific systems such as Dalton, which uncovers molecular properties from data. The dream of building systems that discover scientific hypotheses was pushed to the background with the second AI winter and the subsequent resurgence of subsymbolic methods such as neural networks. Subsymbolic methods emphasize prediction over explanation, and yield models which works well but are difficult or impossible to explain which has earned them the name black box AI. A black-box model cannot be considered a scientific hypothesis, and this development has even led some researchers to suggest that the traditional aim of science - to uncover hypotheses and theories about the structure of reality - is obsolete. Other researchers disagree and argue that subsymbolic methods are useful in many cases, just not for generating scientific theories. == Discovery systems from the 1970s and 1980s == Autoclass was a Bayesian Classification System written in 1986 Automated Mathematician was one of the earliest successful discovery systems. It was written in 1977 and worked by generating a modifying small Lisp programs Eurisko was a Sequel to Automated Mathematician written in 1984 Dalton is a still maintained program capable of calculating various molecular properties initially launched in 1983 and available in open source since 2017 Glauber is a scientific discovery method written in the context of computational philosophy of science launched in 1983 == Modern discovery systems (2009–present) == After a couple of decades with little interest in discovery systems, the interest in using AI to uncover natural laws and scientific explanations was renewed by the work of Michael Schmidt, then a PhD student in Computational Biology at Cornell University. Schmidt and his advisor, Hod Lipson, invented Eureqa, which they described as a symbolic regression approach to "distilling free-form natural laws from experimental data". This work effectively demonstrated that symbolic regression was a promising way forward for AI-driven scientific discovery. Since 2009, symbolic regression has matured further, and today, various commercial and open source systems are actively used in scientific research. Notable examples include Eureqa, now a part of DataRobot AI Cloud Platform, AI Feynman, and QLattice.
Non-human
Non-human (also spelled nonhuman) is any entity displaying some, but not enough, human characteristics to be considered a human. The term has been used in a variety of contexts and may refer to objects that have been developed with human intelligence, such as robots or vehicles. == Organisms == === Animal rights and personhood === In the animal rights movement, it is common to distinguish between "human animals" and "non-human animals". Participants in the animal rights movement generally recognize that non-human animals have some similar characteristics to those of human persons. For example, various non-human animals have been shown to register pain, compassion, memory, and some cognitive function. Some animal rights activists argue that the similarities between human and non-human animals justify giving non-human animals rights that human society has afforded to humans, such as the right to self-preservation, and some even wish for all non-human animals or at least those that bear a fully thinking and conscious mind, such as vertebrates and some invertebrates such as cephalopods, to be given a full right of personhood. === The non-human in philosophy === Contemporary philosophers have drawn on the work of Henri Bergson, Gilles Deleuze, Félix Guattari, and Claude Lévi-Strauss (among others) to suggest that the non-human poses epistemological and ontological problems for humanist and post-humanist ethics, and have linked the study of non-humans to materialist and ethological approaches to the study of society and culture. == Software and robots == The term non-human has been used to describe computer programs and robot-like devices that display some human-like characteristics. In both science fiction and in the real world, computer programs and robots have been built to perform tasks that require human-computer interactions in a manner that suggests sentience and compassion. There is increasing interest in the use of robots in nursing homes and to provide elder care. Computer programs have been used for years in schools to provide one-on-one education with children. The Tamagotchi toy required children to provide care, attention, and nourishment to keep it "alive".
Escapex
Escapex, stylized as escapex, was a mobile app developer specializing in white-label fan engagement apps for celebrities. It was founded by Sephi Shapira in 2014 and has raised $18 million in funding. It allows celebrities to reach fans directly, as well as receiving revenue from fans through its freemium model. == Overview == Shapira is Israeli and previously founded Interchan and MassiveImpact. He graduated from Ben-Gurion University of the Negev. The company has raised $18 million in funding. Its 2018 revenue was $5.5 million. In 2016, the company had 57 employees split between Tel Aviv and New York City. The company's General Manager is Joe Cuello, formerly an executive at MTV, then Chief Creative Officer at TuneCore. Their director of social engagement is Rafe Lopresti-Oakes. A press release from the company described the service as having a "proprietary loyalty program" which allows "monetization of social engagement through e-commerce and in-app advertising". App launches typically offered a contest for one fan to meet the celebrity. The app also allows Escapex to collect and monetize user profiles for advertising. The New York Times described the concept of Escapex, musing, "If people love you, why not make money from them?". == Notable apps == The company has created over 350 applications, including: Enrique Iglesias, June 2016 or earlier Akon, June 2016 or earlier Ricky Martin, June 2016 or earlier Rohan Marley and the Bob Marley estate, February 2017 Marc Anthony, March 2017 Prince Royce, March 2017 Jeremy Renner, March 2017, making over $35,000 per month in April 2019 Galen Gering, June 2017 Yandel, June 2017 Greg Vaughan, June 2017 Jason Thompson, June 2017 Niecy Nash, September 2017 Tyler Posey, September 2017 Osric Chau, January 2018 Chris D'Elia Alessandra Ambrosio, making over $35,000 per month in April 2019 Abigail Ratchford, making over $35,000 per month in April 2019 Amber Rose, making over $35,000 per month in April 2019 Dita Von Teese Tommy Chong === Bollywood stars === Escapex has a large roster of Bollywood celebrities, including: Sunny Leone, December 2016 Remo D'Souza, January 2017 Amy Jackson, March 2017 Kajal Aggarwal, March 2017 Nargis Fakhri, April 2017 Disha Patani Sonam Kapoor Salman Khan == Jeremy Renner app == Renner released a mobile app called "Jeremy Renner" (Android) and "Jeremy Renner Official" (iOS) in March 2017. FastCompany wrote extensively about Renner's app in April 2019, calling it "a surprising new kind of social media". The Ringer's Kate Knibbs, explaining how self-referential the app is, summarized it stating "Jeremy Renner’s Jeremy Renner app is the Jeremy Renner of apps." The community developed to include memes, selfies, and a "Happy Rennsday" event on Wednesdays. As early as October 2017 there were claims of censorship, bullying, and "contest-rigging". In September 2019, comedian Stefan Heck wrote about discovering that any replies through the app would appear as if they were sent by Renner himself in push notifications. Heck wrote about notifications making it appear Renner was a big enthusiast of "porno"; other users made it appear Renner was a big fan of Casey Anthony. Renner had to ask Escapex to shut down the app the following day, stating "The app has jumped the shark. Literally." In September 2020, comedian/writer Caroline Goldfarb and actress Sarah Ramos launched The Renner Files podcast, a six-part series investigating the Jeremy Renner app.
Enterprise cognitive system
Enterprise cognitive systems (ECS) are part of a broader shift in computing, from a programmatic to a probabilistic approach, called cognitive computing. An Enterprise Cognitive System makes a new class of complex decision support problems computable, where the business context is ambiguous, multi-faceted, and fast-evolving, and what to do in such a situation is usually assessed today by the business user. An ECS is designed to synthesize a business context and link it to the desired outcome. It recommends evidence-based actions to help the end-user achieve the desired outcome. It does so by finding past situations similar to the current situation, and extracting the repeated actions that best influence the desired outcome. While general-purpose cognitive systems can be used for different outputs, prescriptive, suggestive, instructive, or simply entertaining, an enterprise cognitive system is focused on action, not insight, to help in assessing what to do in a complex situation. == Key characteristics == ECS have to be: Adaptive: They must learn as information changes, and as goals and requirements evolve. They must resolve ambiguity and tolerate unpredictability. They must be engineered to feed on dynamic data in real time, or near real time. In the Enterprise, near-real time learning from data requires an agile information federation approach to ingest incremental data updates as they occur, and an unsupervised learning approach to ensure that new best practice is leveraged across the organization in a timely manner. Interactive: They must interact easily with users so that those users can define their needs comfortably. They may also interact with other processors, devices, and Cloud services, as well as with people. In the Enterprise, interactions are controlled via existing workflows and UIs. Therefore, embedding best practices directly into these existing interfaces, in the context of a specific step, is critical to ensure maximum end-user adoption. Iterative and stateful: They must aid in defining a problem by asking questions or finding additional source input if a problem statement is ambiguous or incomplete. They must “remember” previous interactions in a process and return information that is suitable for the specific application at that point in time. In the Enterprise, business context is often structured by a business process, and therefore sufficiently data-rich to make relevant recommendations without significant iterations from the end-user. A stateful memory of overall interactions across communication channels is critical for understanding of context, as a static profile will not capture intent and outcome potential the way behavior does. Contextual: They must understand, identify, and extract contextual elements such as meaning, syntax, time, location, appropriate domain, regulations, user's profile, process, task and goal. They may draw on multiple sources of information, including both structured and unstructured digital information, as well as sensory inputs (visual, gestural, auditory, or sensor-provided). In the Enterprise, Context is fragmented and must be aggregated across data types, sources, and locations. In most business environments, such data is captured in existing enterprise information systems, and the effort is linked to quickly source and unify such information. It is rare to have to directly process sensor, audio or visual data in real-time as direct input into the enterprise cognitive system. Instead, these data types are captured by Enterprise Applications and pre-processed into a binary or text format prior to consumption by the System. == Business applications powered by an ECS == Bottlenose – trends and brands monitoring Cybereason – security threat monitoring Dataminr – social media monitoring