In medicine, a prosthesis (pl.: prostheses; from Ancient Greek: πρόσθεσις, romanized: prósthesis, lit. 'addition, application, attachment'), or a prosthetic implant, is an artificial device that replaces a missing body part, which may be lost through physical trauma, disease, or a condition present at birth (congenital disorder). Prostheses may restore the normal functions of the missing body part, or may perform a cosmetic function. A person who has undergone an amputation is sometimes referred to as an amputee, Rehabilitation for someone with an amputation is primarily coordinated by a physiatrist as part of an inter-disciplinary team consisting of physiatrists, prosthetists, nurses, physical therapists, and occupational therapists. Prostheses can be created by hand or with computer-aided design (CAD), a software interface that helps creators design and analyze the creation with computer-generated 2-D and 3-D graphics as well as analysis and optimization tools. == Types == A person's prosthetic device should be designed and assembled to meet their individual appearance and functional needs. Depending on personal circumstances, co-morbidities, budget or health insurance coverage, and access to medical care, decisions may need to balance aesthetics and function. In addition, for some individuals, a myoelectric device, a body-powered device, or an activity-specific device may be appropriate options. The person's future goals and vocational aspirations and potential capabilities may help them choose between one or more devices. Craniofacial prostheses include intra-oral and extra-oral prostheses. Extra-oral prostheses are further divided into hemifacial, auricular (ear), nasal, orbital and ocular. Intra-oral prostheses include dental prostheses, such as dentures, obturators, and dental implants. Prostheses of the neck include larynx substitutes, trachea and upper esophageal replacements, Some prostheses of the torso include breast prostheses which may be either single or bilateral, full breast devices or nipple prostheses. Penile prostheses are used to treat erectile dysfunction, perform phalloplasty procedures in men, and to build a new penis in female-to-male gender reassignment surgeries. === Limb prostheses === Limb prostheses include both upper- and lower-extremity prostheses. Upper-extremity prostheses are used at varying levels of amputation: forequarter, shoulder disarticulation, transhumeral prosthesis, elbow disarticulation, transradial prosthesis, wrist disarticulation, full hand, partial hand, finger, partial finger. A transradial prosthesis is an artificial limb that replaces an arm missing below the elbow. Upper limb prostheses can be categorized in three main categories: Passive devices, Body Powered devices, and Externally Powered (myoelectric) devices. Passive devices can either be passive hands, mainly used for cosmetic purposes, or passive tools, mainly used for specific activities (e.g. leisure or vocational). An extensive overview and classification of passive devices can be found in a literature review by Maat et.al. A passive device can be static, meaning the device has no movable parts, or it can be adjustable, meaning its configuration can be adjusted (e.g. adjustable hand opening). Despite the absence of active grasping, passive devices are very useful in bimanual tasks that require fixation or support of an object, or for gesticulation in social interaction. According to scientific data a third of the upper limb amputees worldwide use a passive prosthetic hand. Body Powered or cable-operated limbs work by attaching a harness and cable around the opposite shoulder of the damaged arm. A recent body-powered approach has explored the utilization of the user's breathing to power and control the prosthetic hand to help eliminate actuation cable and harness. The third category of available prosthetic devices comprises myoelectric arms. This particular class of devices distinguishes itself from the previous ones due to the inclusion of a battery system. This battery serves the dual purpose of providing energy for both actuation and sensing components. While actuation predominantly relies on motor or pneumatic systems, a variety of solutions have been explored for capturing muscle activity, including techniques such as Electromyography, Sonomyography, Myokinetic, and others. These methods function by detecting the minute electrical currents generated by contracted muscles during upper arm movement, typically employing electrodes or other suitable tools. Subsequently, these acquired signals are converted into gripping patterns or postures that the artificial hand will then execute. In the prosthetics industry, a trans-radial prosthetic arm is often referred to as a "BE" or below elbow prosthesis. Lower-extremity prostheses provide replacements at varying levels of amputation. These include hip disarticulation, transfemoral prosthesis, knee disarticulation, transtibial prosthesis, Syme's amputation, foot, partial foot, and toe. The two main subcategories of lower extremity prosthetic devices are trans-tibial (any amputation transecting the tibia bone or a congenital anomaly resulting in a tibial deficiency) and trans-femoral (any amputation transecting the femur bone or a congenital anomaly resulting in a femoral deficiency). A transfemoral prosthesis is an artificial limb that replaces a leg missing above the knee. Transfemoral amputees can have a very difficult time regaining normal movement. In general, a transfemoral amputee must use approximately 80% more energy to walk than a person with two whole legs. This is due to the complexities in movement associated with the knee. In newer and more improved designs, hydraulics, carbon fiber, mechanical linkages, motors, computer microprocessors, and innovative combinations of these technologies are employed to give more control to the user. In the prosthetics industry, a trans-femoral prosthetic leg is often referred to as an "AK" or above the knee prosthesis. A transtibial prosthesis is an artificial limb that replaces a leg missing below the knee. A transtibial amputee is usually able to regain normal movement more readily than someone with a transfemoral amputation, due in large part to retaining the knee, which allows for easier movement. Lower extremity prosthetics describe artificially replaced limbs located at the hip level or lower. In the prosthetics industry, a transtibial prosthetic leg is often referred to as a "BK" or below the knee prosthesis. Prostheses are manufactured and fit by clinical prosthetists. Prosthetists are healthcare professionals responsible for making, fitting, and adjusting prostheses and for lower limb prostheses will assess both gait and prosthetic alignment. Once a prosthesis has been fit and adjusted by a prosthetist, a rehabilitation physiotherapist (called physical therapist in America) will help teach a new prosthetic user to walk with a leg prosthesis. To do so, the physical therapist may provide verbal instructions and may also help guide the person using touch or tactile cues. This may be done in a clinic or home. There is some research suggesting that such training in the home may be more successful if the treatment includes the use of a treadmill. Using a treadmill, along with the physical therapy treatment, helps the person to experience many of the challenges of walking with a prosthesis. In the United Kingdom, 75% of lower limb amputations are performed due to inadequate circulation (dysvascularity). This condition is often associated with many other medical conditions (co-morbidities) including diabetes and heart disease that may make it a challenge to recover and use a prosthetic limb to regain mobility and independence. For people who have inadequate circulation and have lost a lower limb, there is insufficient evidence due to a lack of research, to inform them regarding their choice of prosthetic rehabilitation approaches. Lower extremity prostheses are often categorized by the level of amputation or after the name of a surgeon: Transfemoral (Above-knee) Transtibial (Below-knee) Ankle disarticulation (more commonly known as Syme's amputation) Knee disarticulation (also see knee replacement) Hip disarticulation, (also see hip replacement) Hemi-pelvictomy Partial foot amputations (Pirogoff, Talo-Navicular and Calcaneo-cuboid (Chopart), Tarso-metatarsal (Lisfranc), Trans-metatarsal, Metatarsal-phalangeal, Ray amputations, toe amputations). Van Nes rotationplasty ==== Prosthetic raw materials ==== Prosthetic are made lightweight for better convenience for the amputee. Some of these materials include: Plastics: Polyethylene Polypropylene Acrylics Polyurethane Wood (early prosthetics) Rubber (early prosthetics) Lightweight metals: Aluminum Composites: Carbon fiber reinforced polymers Wheeled prostheses have also been used extensively in the rehabilitation of injured domestic animals, including dogs, cats, pigs, rabbits, and
NRD Cyber Security
NRD Cyber Security is a Lithuanian company that provides cybersecurity solutions, consulting, and other services. The organization specializes in CSIRT and SOC creation, modernization and training. It has helped to establish national and sectorial CSIRTs around the world, including countries, such as Bangladesh, Egypt, Bhutan, Kosovo, Malawi and others. NRD Cyber Security was found in 2013 to provide quality cybersecurity services to nations and organizations. In 2018 it was included in The Deloitte Technology Fast 50 in Europe list. In 2024 it was awarded the #98 place in MSSP Alert Top 250 world's managed security service providers. The company is a member of various cybersecurity organizations, such as Forum of Incident Response and Security Teams (FIRST), The Global Forum on Cyber Expertise (GFCE), Unicrons Lt. It is a strategic partner of The Global Cyber Security Capacity Centre (GCSCC) at University of Oxford.
4E cognition
4E cognition refers to a group of theories in (the philosophy of) cognitive science that challenge traditional views of the mind as something that happens only inside the brain. The four Es stand for: embodied, meaning that a brain is found in and, more importantly, vitally interconnected with a larger physical/biological body; embedded, which refers to the limitations placed on the body by the external environment and laws of nature; extended, which argues that the mind is supplemented and even enhanced by the exterior world (e.g., writing, a calculator, etc.); and enactive, which is the argument that without dynamic processes, actions that require reactions, the mind would be ineffectual. It could be argued that the four Es are compounding extensions of cognition or the mind, being part of a body that is, in turn, part of an environment which limits it but also allows for certain extensions, all of which require dynamic actions and reactions. == History == Ideas of embodied cognition, or rather the idea that our physical bodies play a crucial role in our decision making, can be traced back as far as Plato's dialogues and Aristotelian thought. It was, however, in the twentieth century that this debate began to resemble the current discussion, fueled by disagreements between cognitivists and behaviourists. Tensions within cognitivism, as well as the increasing popularity of neurobiology, led, on the one side, to a predominant focus on internal, cognitive processes while neglecting environmental factors, which in turn caused a push-back fuelling our modern understanding of embodied cognition. The term 4E cognition is hard to trace back to its first use, however, some sources attribute it to Shaun Gallagher and the conference on 4E cognition he organised in 2007, while others indicate the term to be first used in 2006 at an 'Embodied mind workshop' at Cardiff University that Gallagher attended. Embodiment or embodied cognition arguably presents the bridge between cognitivism and 4E cognition as the embodiment of cognitive function provides the necessary conditions for embeddedness, enactedness, and extendedness to connect to cognition. 4E cognition was and is heavily influenced by phenomenology. The ideas are still rather fragmented in nature due to their four main components, which can not be neatly divided, causing conceptual questions of internal boundary concepts. As a young field, it is held back both by its fragmented nature and a relative lack of critical evaluations. It is important to acknowledge that 4E cognition, though young, is a broad field containing and combining several different theoretical perspectives that conflict with one another to varying degrees. The somewhat convoluted and competing nature of the theories that can be grouped as 4E cognition, as well as the field's relative youth, make it difficult to put together an exhaustive history beyond the history of its four main theoretical pillars: embodiment, embeddedness, extendedness, and enactedness. == Importance and core tenets of 4E == If there are separate theories of cognition (e.g., embodied, extended, etc.), why group them under this umbrella, causing important epistemological and especially ontological dilemmas? Notably, other theories of 'non-traditional' cognition are not included under the 4E umbrella. The four E's in 4E cognition importantly all reject, or at a minimum draw into question, some of the core tenets of traditional cognitivism. Importantly, 4E cognition is seen as deindividualizing cognition to some extent, allowing for a broader examination of the interplay of personal, social, political, and ethical aspects that shape human cognition. This can be compared to advancements in the field of epigenetics, which have allowed for a broader examination of environmental (both natural and social) factors and their influence on what had previously only been subject to genetic theorizing. In a similar vein, 4E cognition might also help ground cognition in evolutionary theory by extending cognition to a biological account subject to development over time by means of evolution. Overall, the importance of the extension that is 4E cognition aims to reexamine ideas of a self-centered view of cognition, advocating for a more holistic approach. Ideally, this would allow us to reconsider ideas of justice and individual rights and responsibilities that take into account a more nuanced understanding of the relations between people and their context, balancing self-agency with factors beyond it. === Conceptual differences from cognitive psychology === According to the traditional teachings of cognitive psychology, cognition is a type of information processing based on representational mental structures. This idea, as the name suggests, was heavily influenced by computer science. In this light, the brain is a kind of central processing unit that organises and directs all else. The classical cognitivist view draws a strong boundary between 'the internal' and 'the external', where cognition is solely a subject of 'the internal' realm. The four E's, however, break down this boundary. Cognition can not reside solely within the confines of our heads if it is also embodied, embedded, enacted, and extended. In a way, 4E cognition is interested in the extracranial processes affecting cognition. == From embodied cognition to 4E cognition == === The strong and the weak view === ==== Embodied cognition ==== Broadly speaking, there is a strong and a weak perspective of embodied cognition in 4E cognition. The weak understanding refers to mental processes being causally dependent on extracranial processes. This essentially means that there is a cause and effect or action-reaction relationship between the mind and the body and its environment, etc. The strong perspective views extracranial processes as a (partial) constitutive aspect of cognition. An example here could be using a calculator to solve math problems. The calculator is not part of your brain or mind, but it supports your cognitive processes. === Extracranial processes: bodily or extrabodily === In addition to the weak and the strong reading of 4E cognition, there is also the distinction between bodily and extrabodily extracranial processes. Bodily extracranial processes refer to processes within the body, e.g., sensory perception. Extrabodily extracranial processes refer to processes outside of the body, like the aforementioned calculator example. === Four claims of embodied cognition === ==== Embedded and extended cognition ==== When combining the weak/strong reading of embodied cognition and bodily/extrabodily extracranial process, four claims about embodied cognition emerge: strongly embodied and bodily processes strongly embodied and extrabodily processes weakly embodied and bodily processes weakly embodied and extrabodily processes The first and third claims signify a strong and a weak reading of embodied cognition in the more classical sense. The second claim fits almost perfectly with embedded cognition. Claim two is most compatible with extended cognition. ==== Enacted cognition ==== Finally, enacted cognition refers to cognition being connected to active interaction between a conscious agent and their environment. Here, too, there can be a weak and a strong reading. == Criticisms == Given the divided nature of the field, much criticism surrounding the lack of unity within the field has emerged. In particular, the claims of embodied cognition centering around the body appear to conflict with the tenets of extended cognition, which also appear to conflict with the body/environment distinction that is central to enactivism. Some theoreticians argue that the umbrella of 4E theories is still lacking a common language that might bridge the gaps between the theories that constitute it. There is also the concern that the grouping of such variable theories results in an important loss of nuance and complexity, which is a part of human cognition. Another concern raised is the "dogma of harmony". The criticism contained there regards the notion that within 4E theorizing, there is generally an optimistic and harmonic expectation of the extension between humans and their technologies, ignoring the possibility of those extensions detracting from cognition in some way rather than adding to it. Recent attempts to incorporate embodied cognitive neuroscience have been argued to hold the potential to resolve internal issues within 4E cognition. Overall, a concern often voiced regarding 4E cognition is that its proponents are at best only vaguely interested in cognition. More broadly, this concern reflects the arguably too distracted nature of this emerging field.
ICAD (software)
ICAD (Corporate history: ICAD, Inc., Concentra (name change at IPO in 1995), KTI (name change in 1998), Dassault Systèmes (purchase in 2001) () is a knowledge-based engineering (KBE) system that enables users to encode design knowledge using a semantic representation that can be evaluated for Parasolid output. ICAD has an open architecture that can utilize all the power and flexibility of the underlying language. KBE, as implemented via ICAD, received a lot of attention due to the remarkable results that appeared to take little effort. ICAD allowed one example of end-user computing that in a sense is unparalleled. Most ICAD developers were degreed engineers. Systems developed by ICAD users were non-trivial and consisted of highly complicated code. In the sense of end-user computing, ICAD was the first to allow the power of a domain tool to be in the hands of the user, at the same time being open to allow extensions as identified and defined by the domain expert or subject-matter expert (SME). A COE article looked at the resulting explosion of expectations (see AI winter), which were not sustainable. However, such a bubble burst does not diminish the existence of ability that would exist were expectations and use reasonable or properly managed. == History == The original implementation of ICAD was on a Lisp machine (Symbolics). Some of the principals involved with the development were Larry Rosenfeld, Avrum Belzer, Patrick M. O'Keefe, Philip Greenspun, and David F. Place. The time frame was 1984–85. ICAD started on special-purpose Symbolics Lisp hardware and was then ported to Unix when Common Lisp became portable to general-purpose workstations. The original domain for ICAD was mechanical design with many application successes. However, ICAD has found use in other domains, such as electrical design, shape modeling, etc. An example project could be wind tunnel design or the development of a support tool for aircraft multidisciplinary design. Further examples can be found in the presentations at the annual IIUG (International ICAD Users Group) that have been published in the KTI Vault (1999 through 2002). Boeing and Airbus used ICAD extensively to develop various components in the 1990s and early 21st century. As of 2003, ICAD was featured strongly in several areas as evidenced by the Vision & Strategy Product Vision and Strategy presentation. After 2003, ICAD use diminished. At the end of 2001, the KTI Company faced financial difficulties and laid off most of its best staff. They were eventually bought out by Dassault who effectively scuppered the ICAD product. See IIUG at COE, 2003 (first meeting due to Dassault by KTI) The ICAD system was very expensive, relatively, and was in the price range of high-end systems. Market dynamics couldn't support this as there may not have been sufficient differentiating factors between ICAD and the lower-end systems (or the promises from Dassault). KTI was absorbed by Dassault Systèmes and ICAD is no longer considered the go-forward tool for knowledge-based engineering (KBE) applications by that company. Dassault Systèmes is promoting a suite of tools oriented around version 5 of their popular CATIA CAD application, with Knowledgeware the replacement for ICAD. As of 2005, things were still a bit unclear. ICAD 8.3 was delivered. The recent COE Aerospace Conference had a discussion about the futures of KBE. One issue involves the stacking of 'meta' issues within a computer model. How this is resolved, whether by more icons or the availability of an external language, remains to be seen. The Genworks GDL product (including kernel technology from the Gendl Project) is the nearest functional equivalent to ICAD currently available. == Particulars == ICAD provided a declarative language (IDL) using New Flavors (never converted to Common Lisp Object System (CLOS)) that supported a mechanism for relating parts (defpart) via a hierarchical set of relationships. Technically, the ICAD Defpart was a Lisp macro; the ICAD defpart list was a set of generic classes that can be instantiated with specific properties depending upon what was represented. This defpart list was extendible via composited parts that represented domain entities. Along with the part-subpart relations, ICAD supported generic relations via the object modeling abilities of Lisp. Example applications of ICAD range from a small collection of defparts that represents a part or component to a larger collection that represents an assembly. In terms of power, an ICAD system, when fully specified, can generate thousands of instances of parts on a major assembly design. One example of an application driving thousands of instances of parts is that of an aircraft wing – where fastener type and placement may number in the thousands, each instance requiring evaluation of several factors driving the design parameters. == Futures (KBE, etc.) == One role for ICAD may be serving as the defining prototype for KBE which would require that we know more about what occurred the past 15 years (much information is tied up behind corporate firewalls and under proprietary walls). With the rise of functional programming languages (an example is Haskell) in the markets, perhaps some of the power attributable to Lisp may be replicated.
Ramification problem
In philosophy and artificial intelligence (especially, knowledge based systems), the ramification problem is concerned with the indirect consequences of an action. It might also be posed as how to represent what happens implicitly due to an action or how to control the secondary and tertiary effects of an action. It is strongly connected to, and is opposite the qualification side of, the frame problem. Limit theory helps in operational usage. For instance, in KBE derivation of a populated design (geometrical objects, etc., similar concerns apply in shape theory), equivalence assumptions allow convergence where potentially large, and perhaps even computationally indeterminate, solution sets are handled deftly. Yet, in a chain of computation, downstream events may very well find some types of results from earlier resolutions of ramification as problematic for their own algorithms.
Progress in artificial intelligence
Progress in artificial intelligence (AI) refers to the advances, milestones, and breakthroughs that have been achieved in the field of artificial intelligence over time. AI is a branch of computer science that aims to create machines and systems capable of performing tasks that typically require human intelligence. AI applications have been used in a wide range of fields including medical diagnosis, finance, robotics, law, video games, agriculture, and scientific discovery. The society as a whole is looking for artificial intelligence to be on a key factor in the upcming years because of its potential. However, many AI applications are not perceived as AI: "A lot of cutting-edge AI has filtered into general applications, often without being called AI because once something becomes useful enough and common enough it's not labeled AI anymore." "Many thousands of AI applications are deeply embedded in the infrastructure of every industry." In the late 1990s and early 2000s, AI technology became widely used as elements of larger systems, but the field was rarely credited for these successes at the time. Kaplan and Haenlein structure artificial intelligence along three evolutionary stages: Artificial narrow intelligence – AI capable only of specific tasks; Artificial general intelligence – AI with ability in several areas, and able to autonomously solve problems they were never even designed for; Artificial superintelligence – AI capable of general tasks, including scientific creativity, social skills, and general wisdom. To allow comparison with human performance, artificial intelligence can be evaluated on constrained and well-defined problems. Such tests have been termed subject-matter expert Turing tests. Also, smaller problems provide more achievable goals and there are an ever-increasing number of positive results. In 2023, humans still substantially outperformed both GPT-4 and other models tested on the ConceptARC benchmark. Those models scored 60% on most, and 77% on one category, while humans scored 91% on all and 97% on one category. However, later research in 2025 showed that human-generated output grids were only accurate 73% of the time, while AI models available that year managed to score above 77%. == History == Increasing, promoting or constraining AI progress has often be done via controlling or increasing the amount of compute. == Current performance in specific areas == There are many useful abilities that can be described as showing some form of intelligence. This gives better insight into the comparative success of artificial intelligence in different areas. AI, like electricity or the steam engine, is a general-purpose technology. There is no consensus on how to characterize which tasks AI tends to excel at. Some versions of Moravec's paradox observe that humans are more likely to outperform machines in areas such as physical dexterity that have been the direct target of natural selection. While projects such as AlphaZero have succeeded in generating their own knowledge from scratch, many other machine learning projects require large training datasets. Researcher Andrew Ng has suggested, as a "highly imperfect rule of thumb", that "almost anything a typical human can do with less than one second of mental thought, we can probably now or in the near future automate using AI." Games provide a high-profile benchmark for assessing rates of progress; many games have a large professional player base and a well-established competitive rating system. AlphaGo brought the era of classical board-game benchmarks to a close when Artificial Intelligence proved their competitive edge over humans in 2016. Deep Mind's AlphaGo AI software program defeated the world's best professional Go Player Lee Sedol. Games of imperfect knowledge provide new challenges to AI in the area of game theory; the most prominent milestone in this area was brought to a close by Libratus' poker victory in 2017. E-sports continue to provide additional benchmarks; Facebook AI, Deepmind, and others have engaged with the popular StarCraft franchise of videogames. Broad classes of outcome for an AI test may be given as: optimal: it is not possible to perform better (note: some of these entries were solved by humans) super-human: performs better than all humans high-human: performs better than most humans par-human: performs similarly to most humans sub-human: performs worse than most humans === Optimal === Tic-tac-toe Connect Four: 1988 Checkers (aka 8x8 draughts): Weakly solved (2007) Rubik's Cube: Mostly solved (2010) Heads-up limit hold'em poker: Statistically optimal in the sense that "a human lifetime of play is not sufficient to establish with statistical significance that the strategy is not an exact solution" (2015) === Super-human === Othello (aka reversi): c. 1997 Scrabble: 2006 Backgammon: c. 1995–2002 Chess: Supercomputer (c. 1997); Personal computer (c. 2006); Mobile phone (c. 2009); Computer defeats human + computer (c. 2017) Jeopardy!: Question answering, although the machine did not use speech recognition (2011) Arimaa: 2015 Shogi: c. 2017 Go: 2017 Heads-up no-limit hold'em poker: 2017 Six-player no-limit hold'em poker: 2019 Gran Turismo Sport: 2022 === High-human === Crosswords: c. 2012 Freeciv: 2016 Dota 2: 2018 Bridge card-playing: According to a 2009 review, "the best programs are attaining expert status as (bridge) card players", excluding bidding. StarCraft II: 2019 Mahjong: 2019 Stratego: 2022 No-Press Diplomacy: 2022 Hanabi: 2022 Natural language processing === Par-human === Optical character recognition for ISO 1073-1:1976 and similar special characters. Classification of images Handwriting recognition Facial recognition Visual question answering SQuAD 2.0 English reading-comprehension benchmark (2019) SuperGLUE English-language understanding benchmark (2020) Some school science exams (2019) Some tasks based on Raven's Progressive Matrices Many Atari 2600 games (2015) === Sub-human === Optical character recognition for printed text (nearing par-human for Latin-script typewritten text) Object recognition Various robotics tasks that may require advances in robot hardware as well as AI, including: Stable bipedal locomotion: Bipedal robots can walk, but are less stable than human walkers (as of 2017) Humanoid soccer Speech recognition: "nearly equal to human performance" (2017) Explainability. Current medical systems can diagnose certain medical conditions well, but cannot explain to users why they made the diagnosis. Many tests of fluid intelligence (2020) Bongard visual cognition problems, such as the Bongard-LOGO benchmark (2020) Visual Commonsense Reasoning (VCR) benchmark (as of 2020) Stock market prediction: Financial data collection and processing using Machine Learning algorithms Angry Birds video game, as of 2020 Various tasks that are difficult to solve without contextual knowledge, including: Translation Word-sense disambiguation == Proposed tests of artificial intelligence == In his famous Turing test, Alan Turing picked language, the defining feature of human beings, for its basis. The Turing test is now considered too exploitable to be a meaningful benchmark. The Feigenbaum test, proposed by the inventor of expert systems, tests a machine's knowledge and expertise about a specific subject. A paper by Jim Gray of Microsoft in 2003 suggested extending the Turing test to speech understanding, speaking and recognizing objects and behavior. Proposed "universal intelligence" tests aim to compare how well machines, humans, and even non-human animals perform on problem sets that are generic as possible. At an extreme, the test suite can contain every possible problem, weighted by Kolmogorov complexity; however, these problem sets tend to be dominated by impoverished pattern-matching exercises where a tuned AI can easily exceed human performance levels. == Exams == According to OpenAI, in 2023 GPT-4 achieved high scores on several standardized and professional examinations, including around the 90th percentile on the Uniform Bar Exam, the 89th percentile on the mathematics section of the SAT, the 93rd percentile on SAT Reading and Writing, the 54th percentile on the analytical writing section of the GRE, the 88th percentile on GRE quantitative reasoning, and the 99th percentile on GRE verbal reasoning. OpenAI also reported that GPT-4 scored in the 99th to 100th percentile on the 2020 USA Biology Olympiad semifinal exam and earned top scores on several AP exams. Independent researchers found in 2023 that ChatGPT based on GPT-3.5 performed "at or near the passing threshold" on all three parts of the United States Medical Licensing Examination (USMLE), suggesting that large language models could reach passing-level performance on some medical knowledge assessments even without domain-specific fine-tuning. GPT-3.5 was also reported to attain a low but passing grade on examinations for four law school courses at the University of Minnes
GENESIS (software)
GENESIS (The General Neural Simulation System) is a simulation environment for constructing realistic models of neurobiological systems at many levels of scale including: sub-cellular processes, individual neurons, networks of neurons, and neuronal systems. These simulations are “computer-based implementations of models whose primary objective is to capture what is known of the anatomical structure and physiological characteristics of the neural system of interest”. GENESIS is intended to quantify the physical framework of the nervous system in a way that allows for easy understanding of the physical structure of the nerves in question. “At present only GENESIS allows parallelized modeling of single neurons and networks on multiple-instruction-multiple-data parallel computers.” Development of GENESIS software spread from its home at Caltech to labs at the University of Texas at San Antonio, the University of Antwerp, the National Centre for Biological Sciences in Bangalore, the University of Colorado, the Pittsburgh Supercomputing Center, the San Diego Supercomputer Center, and Emory University. == Neurons and Neural Systems == GENESIS works by creating simulation environments for constructing models of neurons or neural systems. "Nerve cells are capable of communicating with each other in such a highly structured manner as to form neuronal networks. To understand neural networks, it is necessary to understand the ways in which one neuron communicates with another through synaptic connections and the process called synaptic transmission". Neurons have a specialized structure for their function, they "are different from most other cells in the body in that they are polarized and have distinct morphological regions, each with specific functions". The two important regions of a neuron are the dendrite and the axon. "Dendrites are the region where one neuron receives connections from other neurons. The cell body or soma contains the nucleus and the other organelles necessary for cellular function. The axon is a key component of nerve cells over which information is transmitted from one part of the neuron (e.g., the cell body) to the terminal regions of the neuron". The third important piece of a neuron is the synapse. "The synapse is the terminal region of the axon this is where one neuron forms a connection with another and conveys information through the process of synaptic transmission". Neural networks like the ones simulated with GENESIS software can quickly become highly complex and difficult to understand. "Just a few interconnected neurons (a microcircuit) can perform sophisticated tasks such as mediate reflexes, process sensory information, generate locomotion and mediate learning and memory. Even more complex networks, macrocircuits, consist of multiple embedded microcircuits. Macrocircuits mediate higher brain functions such as object recognition and cognition". GENESIS endeavors to simulate neural systems as they are found in nature. Often, "a neuron can receive contacts from up to 10,000 presynaptic neurons, and, in turn, any one neuron can contact up to 10,000 postsynaptic neurons. The combinatorial possibility could give rise to enormously complex neuronal circuits or network topologies, which might be very difficult to understand". == History == GENESIS was developed by Dr. James M. Bower, in the Caltech laboratory, and first released to the public in 1988 in association with the first Methods in Computational Neuroscience Course at the Marine Biological Laboratory in Woods Hole, MA. Full source code for the software was released in the same year under an open software model for development. It's now supported by the Computational Biology Initiative at the University of Texas at San Antonio and is available free along with tutorial guides on its use. P-GENESIS, a parallel version of GENESIS, was first run in 1990 on the Intel Delta, which was the prototype for the Intel Paragon family of massively parallel supercomputers. == How GENESIS Works == GENESIS is useful in creating a simulation environment for constructing models of neurobiological systems, such as: sub-cellular processes individual neurons networks of neurons neuronal systems The GENESIS system is complicated, but relatively easy to use. An individual can input commands through one of three ways: script files, graphical user interface, or the GENESIS command shell. These commands are then processed by the script language interpreter. "The Script Language Interpreter processes commands entered through the keyboard, script files, or the graphical user interface, and passes them to the GENESIS simulation engine. The simulation engine also loads compiled object libraries, reads and writes data files, and interacts with the graphical user interface". Below is a graphical representation of the user input process and a sample GENESIS output. == Applications == Most current applications for GENESIS involve realistic simulations of biological systems. It is usually used to simulate the behavior of larger brain structures, for example the cerebral cortex. These studies most often occur in lab courses in neural simulation at Caltech and the Marine Biological Laboratory at Woods Hole, Massachusetts. GENESIS can be used in combination with Yale University’s software called NEURON as a means for scientists to collaborate to construct a physical description of the nervous system. The GENESIS software can also be used with Kinetikit in the modeling of signal transduction pathways. GENESIS has been used in many studies. Some of these studies involve research that focuses on the development of software that would be useful across many disciplines. Others are studies of neurons, such as Purkinje cells. These studies used GENESIS to simulate Purkinje cells and could be useful for the planning and development of later experiments using the GENESIS software. There may also be biomedical applications of the software. For example, St. Jude Medical in Europe has developed an implanted GENESIS device.