False answer supervision (FAS) refers to VoIP fraud where the billed duration for the caller is more than the duration of the actual connection duration. The FAS is usually performed by VoIP wholesalers in their softswitches for randomly selected calls. Adding a small amount of extra billed seconds for many calls results in significant revenue for the VoIP wholesaler. == Implementation of FAS == The FAS fraud can be implemented in a softswitch in many different ways. These include: False billing of party A without calling a party B. Usually a fake ringback tone, loopback audio or voicemail message is played Start of billing before actual answer of party B Extra billing after disconnection of party B == Detection of FAS == The FAS can be detected and blocked in a softswitch. Common methods are: Manual verification of call detail records: listening to voice recordings Identification of FAS types and using algorithms to automatically detect the FAS RTP audio signal processing: detection of voice RTP audio signal processing: detection of silence RTP audio signal processing: detection of ringback tone
Open Syllabus Project
The Open Syllabus Project (OSP) is an online open-source platform that catalogs and analyzes millions of college syllabi. Founded by researchers from the American Assembly at Columbia University, the OSP has amassed the most extensive collection of searchable syllabi. Since its beta launch in 2016, the OSP has collected over 7 million course syllabi from over 80 countries, primarily by scraping publicly accessible university websites. The project is directed by Joe Karaganis. == History == The OSP was formed by a group of data scientists, sociologists, and digital-humanities researchers at the American Assembly, a public-policy institute based at Columbia University. The OSP was partly funded by the Sloan Foundation and the Arcadia Fund. Joe Karaganis, former vice-president of the American Assembly, serves as the project director of the OSP. The project builds on prior attempts to archive syllabi, such as H-Net, MIT OpenCourseWare, and historian Dan Cohen's defunct Syllabus Finder website (Cohen now sits on the OSP's advisory board). The OSP became a non-profit and independent of the American Assembly in November 2019. In January 2016, the OSP launched a beta version of their "Syllabus Explorer," which they had collected data for since 2013. The Syllabus Explorer allows users to browse and search texts from over one million college course syllabi. The OSP launched a more comprehensive version 2.0 of the Syllabus Explorer in July 2019. The newer version includes an interactive visualization that displays texts as dots on a knowledge map. As of 2022, the OSP has collected over 7 million course syllabi. The Syllabus Explorer represents the "largest collection of searchable syllabi ever amassed." == Methodology == The OSP has collected syllabi data from over 80 countries dating to 2000. The syllabi stem from over 4,000 worldwide institutions. Most of the OSP's data originates from the United States. Canada, Australia, and the U.K also have large datasets. The OSP primarily collects syllabi by scraping publicly accessible university websites. The OSP also allows syllabi submissions from faculty, students, and administrators. The OSP developers use machine learning and natural language processing to extract metadata from such syllabi. Since only metadata is collected, no individual syllabus or personal identifying information is found in the OSP database. The OSP classifies the syllabi into 62 subject fields – corresponding to the U.S. Department of Education's Classification of Instructional Programs (CIP). Additionally, the OSP assigns each text a "teaching score" from 0–100. This score represents the text's percentile rank among citations in the total citation count and is a numerical indicator of the relative frequency of which a particular work is taught. The OSP also has data on which texts are most likely to be assigned together. The developers behind the OSP admit that the database is incomplete and likely contains "a fair number of errors." Karaganis estimates that 80–100 million syllabi exist in the United States alone. The OSP is unable to access syllabi behind private course-management software like Blackboard. == Notable findings == === Anthropology === Using data from the OSP, anthropologist Laurence Ralph uncovered that black anthropologists are "woefully under-represented in (if not erased from) most anthropology syllabi." Black authors wrote less than 1 percent of the top 1,000 assigned works. === Economics === The database indicates Greg Mankiw is the most frequently cited author for college economics courses. === English literature === The OSP found that Mary Shelley's Frankenstein was the most widely taught novel in college courses. Additionally, the majority of novels published after 1945 taught in English classes were historical fiction. === Female writers === The most read female writer on college campuses is Kate L. Turabian for her A Manual for Writers of Research Papers, Theses, and Dissertations . Turabian is followed by Diana Hacker, Toni Morrison, Jane Austen, and Virginia Woolf. === Film === The most assigned film according to the OSP is the 1929 Soviet documentary film, Man with a Movie Camera. English filmmaker Alfred Hitchcock is the most assigned director in college courses. === History === Historians George Brown Tindall and David Emory Shi's America: A Narrative History is the number one assigned textbook for history, followed by Anne Moody's memoir, Coming of Age in Mississippi. === Philosophy === The most assigned texts in the field of philosophy include Aristotle's Nicomachean Ethics, John Stuart Mill's Utilitarianism, and Plato's Republic. Plato's Republic was also the second most assigned text in universities in the English-speaking world (only behind Strunk and White's Elements of Style). === Physics === David Halliday's et al. Fundamentals of Physics is the number one ranked physics textbook in the OSP's database. === Political science === Data from the OSP indicates that the dominant political science texts are written almost exclusively by white men and scholars based in the West. In the top 200 most-frequently assigned works, 15 are authored by at least one woman. === Public administration === American president Woodrow Wilson's article "The Study of Administration" was the most frequently assigned text in public affairs and administration syllabi. == Reception == According to William Germano et al., the OSP is a "fascinating resource but is also prone to misrepresenting or at least distracting us from the most important business of a syllabus: communicating with students." Historian William Caferro remarks that the OSP is a "tacit experience of sharing, but a useful one." English professor Bart Beaty writes that, "Despite the many reservations about the completeness of its data, the OSP provides a rare opportunity for scholars to move beyond the anecdotal in discussions of canon-formation in teaching." Media theorist Elizabeth Losh opines that "big data approaches", like the OSP, may "raise troubling questions for instructors about informed consent, pedagogical privacy, and quantified metrics."
Pretext
A pretext (adj.: pretextual) is an excuse to do something or say something that is not accurate. Pretexts may be based on a half-truth or developed in the context of a misleading fabrication. Pretexts have been used to conceal the true purpose or rationale behind actions and words. They are often heard in political speeches. In US law, a pretext usually describes false reasons that hide the true intentions or motivations for a legal action. If a party can establish a prima facie case for the proffered evidence, the opposing party must prove that these reasons were "pretextual" or false. This can be accomplished by directly demonstrating that the motivations behind the presentation of evidence is false, or indirectly by evidence that the motivations are not "credible". In Griffith v. Schnitzer, an employment discrimination case, a jury award was reversed by a Court of Appeals because the evidence was not sufficient that the defendant's reasons were "pretextual". That is, the defendant's evidence was either undisputed, or the plaintiff's was "irrelevant subjective assessments and opinions". A "pretextual" arrest by law enforcement officers is one carried out for illegal purposes such as to conduct an unjustified search and seizure. As one example of pretext, in the 1880s, the Chinese government raised money on the pretext of modernizing the Chinese navy. Instead, these funds were diverted to repair a ship-shaped, two-story pavilion which had been originally constructed for the mother of the Qianlong Emperor. This pretext and the Marble Barge are famously linked with Empress Dowager Cixi. This architectural folly, known today as the Marble Boat (Shifang), is "moored" on Lake Kunming in what the empress renamed the "Garden for Cultivating Harmony" (Yiheyuan). Another example of pretext was demonstrated in the speeches of the Roman orator Cato the Elder (234–149 BC). For Cato, every public speech became a pretext for a comment about Carthage. The Roman statesman had come to believe that the prosperity of ancient Carthage represented an eventual and inevitable danger to Rome. In the Senate, Cato famously ended every speech by proclaiming his opinion that Carthage had to be destroyed (Carthago delenda est). This oft-repeated phrase was the ultimate conclusion of all logical argument in every oration, regardless of the subject of the speech. This pattern persisted until his death in 149, which was the year in which the Third Punic War began. In other words, any subject became a pretext for reminding his fellow senators of the dangers Carthage represented. == Uses in warfare == The early years of Japan's Tokugawa shogunate were unsettled, with warring factions battling for power. The causes for the fighting were in part pretextual, but the outcome brought diminished armed conflicts after the Siege of Osaka in 1614–1615. The next two-and-a-half centuries of Japanese history were comparatively peaceful under the successors of Tokugawa Ieyasu and the bakufu government he established. === United States === During the War of 1812, US President James Madison was often accused of using impressment of American sailors by the Royal Navy as a pretext to invade Canada. The sinking of the USS Maine in 1898 was blamed on the Spanish, despite early reports of it having been an accident, contributing to U.S. entry into the Spanish–American War. The slogan "Remember the Maine! To hell with Spain!" was used as a rallying cry. Some have argued that United States President Franklin D. Roosevelt used the attack on Pearl Harbor by Japanese forces on December 7, 1941, as a pretext to enter World War II. American soldiers and supplies had been assisting British and Soviet operations for almost a year by this point, and the United States had thus "chosen a side", but due to the political climate in the States at the time and some campaign promises made by Roosevelt that he would not send American troops to fight in foreign wars, Roosevelt could not declare war for fear of public backlash. The attack on Pearl Harbor united the American people's resolve against the Axis powers and created the bellicose atmosphere in which to declare war. The 1964 Gulf of Tonkin incident, later revealed to have been partly provoked and partly not to have happened, was used to bring the United States fully into the Vietnam War. United States President George W. Bush used the September 11 attacks and faulty intelligence about the existence of weapons of mass destruction as a pretext for the war in Iraq. == Social engineering == A type of social engineering called pretexting uses a pretext to elicit information fraudulently from a target. The pretext in this case includes research into the identity of a certain authorized person or personality type in order to establish legitimacy in the mind of the target.
POSC Caesar
POSC Caesar Association (PCA) is an international, open and not-for-profit, member organization that promotes the development of open specifications to be used as standards for enabling the interoperability of data, software and related matters. PCA is the initiator of ISO 15926 "Integration of life-cycle data for process plants including oil and gas production facilities" and is committed to its maintenance and enhancement. Nils Sandsmark has been the General Manager of POSC Caesar Association since 1999 and Thore Langeland, Norwegian Oil Industry Association (Norwegian: Oljeindustriens Landsforening, OLF), is the chairman of the board. == History == === Caesar Offshore === The first predecessor of POSC Caesar Association, the Caesar Offshore program, started in 1993. The original focus was on standardizing technical data definitions for capital intensive projects at the handover from the EPC contractor to the owner/operators of onshore and offshore oil and gas production facilities. The program was sponsored by The Research Council of Norway, two EPC contractors (Aker Maritime and Kværner), three owners/operators (Norsk Hydro, Saga Petroleum and Statoil) and DNV as service provider and project owner. === POSC Caesar project === During the period 1994–96, Caesar Offshore Program was defined as a project of Petrotechnical Open Software Corporation (POSC) (now Energistics), and changed its name to the POSC Caesar Project. In 1995 the project was joined by BP, Brown and Root and Elf Aquitaine and in 1997 by Intergraph, IBM, Oracle, Lloyd's, Shell, ABB and UMOE Technologies. During that time, POSC Caesar also became a member of European Process Industries STEP Technical Liaison Executive (EPISTLE) where it collaborates with PISTEP (UK), and USPI-NL (The Netherlands) on the development of ISO 10303, also known as "Standard for the Exchange of Product model data (STEP)". === POSC Caesar Association === In 1997, POSC Caesar Association was founded as an independent, global, non-profit, member organization. POSC Caesar Association serves an international membership and collaborates with other international organizations. It has its main office in Norway. Albeit the name of POSC Caesar Association still hints to its past as a project within the Petrotechnical Open Software Corporation (POSC) (now Energistics), from 1997 onwards, the organization has been independent. Energistics and POSC Caesar Association do collaborate, and are formally member in each other's organization. == Membership == POSC Caesar Association has with its current 36 members from around the world and has established an international footprint (with a strong membership in Norway) that includes a variety of backgrounds, from academia and solution providers to engineering contractors and owners/operators. The members are (subdivided by organization type): Associations: Energistics (USA) and The Norwegian Oil Industry Association (OLF, Norway); Universities and Research Institutes: International Research Institute of Stavanger (IRIS, Norway), Norwegian University of Science and Technology (NTNU, Norway), Korea Advanced Institute of Science and Technology (KAIST, Korea), SINTEF (Norway), University of Bergen (Norway), University of Oslo (Norway), University of Stavanger (Norway), University of Tromsø (Norway) and Western Norway Research Institute (Norway); Oil and Gas Companies: BP (UK), Petronas (Malaysia) and Statoil (Norway); Engineering contractors and consultants: Akvaplan-niva (Norway), Aker Solutions (Norway), Asset Life Cycle Information Management (ALCIM, Malaysia), CAESAR systems (USA), Bechtel (USA), Det Norske Veritas (DNV, Norway), Information Logic (USA) and iXIT Engineering Technology (Germany), Phusion IM Ltd (UK); Solution providers: Aveva (UK), Bentley Systems (USA), Jotne EPM Technology (Norway), Epsis (Norway), Eurostep (Sweden), International Business Machines Corporation (IBM, USA), Siemens - Comos Industry Solutions (before Innotec) (Germany), Intergraph (USA), Invenia (Norway), Keel Solution (Denmark), Noumenon (UK), NRX (Canada), Octaga (Norway) and Tektonisk (Norway). In general, the organization holds three membership meetings a year; one in January / February in North-America (typically USA), one in April / May in Europe (typically Norway) and one in October in Asia (typically Malaysia). == Activities and services == === Initiator and custodian of ISO 15926 === In consultation with the other EPISTLE members and the International Organization for Standardization (ISO), it was decided in 2003 (some say already in 1997) that for modeling-technical reasons it was better to discontinue the development of ISO 10303 and to initiate the development of ISO 15926 "Integration of life-cycle data for process plants including oil and gas production facilities." Over the years, the scope of the standard has increased from the initial capital-intensive projects in the upstream oil and gas industry, to include also relevant terminology for downstream oil and gas industry applications and to deal with real-time data related to the actual oil and gas production. ISO 15926 has also over the years evolved from a dictionary (a list of terms with definitions), over a taxonomy (added hierarchy) to an ontology (a formal representation of a set of concepts within a domain and the relationships between those concepts). ISO 15926 is therefore sometimes nicknamed the "Oil and Gas Ontology", for some considered to be an essential prerequisite together with Semantic Web technologies to get to better interoperability, an optimal use of all available data across boundaries and an increase in efficiency. This is what some call the next generation of Integrated Operations. === Reference data services === Placeholders: Flow scheme of WIP - RDS - ISO and role of SIGs RDS Standards in database pilot (ISO) === Special interest groups === Placeholders: Overview of SIGs Drilling and Completion Reservoir and Production Operations and Maintenance == Projects == There are a number of projects (co-)organized by POSC Caesar Association working on the extension of the ISO 15926 standard in different application areas. === Capital intensive projects application domain === The following projects are running at the moment (August 2009): The ADI Project of FIATECH, to build the tools (which will then be made available in the public domain) The IDS Project of POSC Caesar Association, to define product models required for data sheets A joint collaboration project between FIATECH POSC Caesar Association is the ADI-IDS project is the ISO 15926 WIP === Upstream oil and gas industry application domain === The following projects are currently running (August 2009): The Integrated Operations in the High North (IOHN) project is working on extending ISO 15926 to handle real-time data transmission and (pre-)processing to enable the next generation of Integrated Operations. The Environment Web project to include environmental reporting terms and definitions as used in EPIM's EnvironmentWeb in ISO 15926. Finalised projects include: The Integrated Information Platform (IIP) project working on establishing a real-time information pipeline based on open standards. It worked among others on: Daily Drilling Report (DDR) to including all terms and definitions in ISO 15926. This standard became mandatory on February 1, 2008 for reporting on the Norwegian Continental Shelf by the Norwegian Petroleum Directorate (NPD) and Safety Authority Norway (PSA). NPD says that the quality of the reports has improved considerably since. Daily Production Report (DPR) to including all terms and definitions in ISO 15926. This standard was tested successfully on the Valhall (BP-operated) and Åsgard (StatoilHydro-operated) fields offshore Norway. The terminology and XML schemata developed have also been included in Energistics’ PRODML standard. == Conferences and events == === Semantic Days === === Sogndal academic network meeting === == Collaborations == POSC Caesar is collaborating with a number of standardization bodies, including: Mimosa: collaboration on open information standards for Operations and Maintenance mainly for the downstream oil and gas industry; FIATECH: collaboration on open information standards for life cycle data of capital projects; Energistics: collaboration on information standards for the upstream oil and gas industry, including WITSML and PRODML; OASIS: collaboration on e-business standards; ISO TC184/SC4: the host of the ISO 15926 standard.
Paradigms of AI Programming
Paradigms of AI Programming: Case Studies in Common Lisp (ISBN 1-55860-191-0) is a well-known programming book by Peter Norvig about artificial intelligence programming using Common Lisp. == History == The Lisp programming language has survived since 1958 as a primary language for artificial intelligence research. This text was published in 1992 as the Common Lisp standard was becoming widely adopted. Norvig introduces Lisp programming in the context of classic AI programs, including General Problem Solver (GPS) from 1959, ELIZA: Dialog with a Machine, from 1966, and STUDENT: Solving Algebra Word Problems, from 1964. The book covers more recent AI programming techniques, including Logic Programming, Object-Oriented Programming, Knowledge Representation, Symbolic Mathematics and Expert Systems.
GPT-4o
GPT-4o ("o" for "omni") is a multilingual, multimodal generative pre-trained transformer developed by OpenAI and released in May 2024. It can process and generate text, images and audio. Upon release, GPT-4o was free in ChatGPT, though paid subscribers had higher usage limits. GPT-4o was removed from ChatGPT in August 2025 when GPT-5 was released, but OpenAI reintroduced it for paid subscribers after users complained about the sudden removal. GPT-4o's audio-generation capabilities are used in ChatGPT's Advanced Voice Mode. On July 18, 2024, OpenAI released GPT-4o mini, a smaller version of GPT-4o which replaced GPT-3.5 Turbo on the ChatGPT interface. The image generation model GPT Image 1, which is based on GPT-4o, replaced DALL-E 3 in ChatGPT in March 2025. OpenAI retired GPT-4o from ChatGPT on February 13, 2026. However, as of February 2026 the voice mode is still powered by GPT-4o or GPT-4o mini, depending on the usage and plan. == Background == Multiple versions of GPT-4o were originally secretly launched under different names on Arena (formerly LMArena and Chatbot Arena) as three different models. These three models were called gpt2-chatbot, im-a-good-gpt2-chatbot, and im-also-a-good-gpt2-chatbot. On 7 May 2024, OpenAI CEO Sam Altman tweeted "im-a-good-gpt2-chatbot", which was commonly interpreted as a confirmation that these were new OpenAI models being A/B tested. == Capabilities == When released in May 2024, GPT-4o achieved state-of-the-art results in voice, multilingual, and vision benchmarks, setting new records in audio speech recognition and translation. GPT-4o scored 88.7 on the Massive Multitask Language Understanding (MMLU) benchmark compared to 86.5 for GPT-4. Unlike GPT-3.5 and GPT-4, which rely on other models to process sound, GPT-4o natively supports voice-to-voice. The Advanced Voice Mode was delayed and finally released to ChatGPT Plus and Team subscribers in September 2024. On 1 October 2024, the Realtime API was introduced. When released, the model supported over 50 languages, which OpenAI claims cover over 97% of speakers. GPT-4o has knowledge up to October 2023 and a context length of 128k tokens. === Corporate customization === In August 2024, OpenAI introduced a new feature allowing corporate customers to customize GPT-4o using proprietary company data. This customization, known as fine-tuning, enables businesses to adapt GPT-4o to specific tasks or industries, enhancing its utility in areas like customer service and specialized knowledge domains. Previously, fine-tuning was available only on the less powerful model GPT-4o mini. The fine-tuning process requires customers to upload their data to OpenAI's servers, with the training typically taking one to two hours. OpenAI's focus with this rollout is to reduce the complexity and effort required for businesses to tailor AI solutions to their needs, potentially increasing the adoption and effectiveness of AI in corporate environments. == GPT-4o mini == On July 18, 2024, OpenAI released a smaller and cheaper version, GPT-4o mini. According to OpenAI, its low cost is expected to be particularly useful for companies, startups, and developers that seek to integrate it into their services, which often make a high number of API calls. Its API costs $0.15 per million input tokens and $0.6 per million output tokens, compared to $2.50 and $10, respectively, for GPT-4o. It is also significantly more capable and 60% cheaper than GPT-3.5 Turbo, which it replaced on the ChatGPT interface. The price after fine-tuning doubles: $0.3 per million input tokens and $1.2 per million output tokens. == Controversies == === Scarlett Johansson controversy === As released, GPT-4o offered five voices: Breeze, Cove, Ember, Juniper, and Sky. A similarity between the voice of American actress Scarlett Johansson and Sky was quickly noticed. On May 14, Entertainment Weekly asked themselves whether this likeness was on purpose. On May 18, Johansson's husband, Colin Jost, joked about the similarity in a segment on Saturday Night Live. On May 20, 2024, OpenAI disabled the Sky voice. Scarlett Johansson starred in the 2013 sci-fi movie Her, playing Samantha, an artificially intelligent virtual assistant personified by a female voice. As part of the promotion leading up to the release of GPT-4o, Sam Altman on May 13 tweeted a single word: "her". OpenAI stated that each voice was based on the voice work of a hired actor. According to OpenAI, "Sky's voice is not an imitation of Scarlett Johansson but belongs to a different professional actress using her own natural speaking voice." CTO Mira Murati stated "I don't know about the voice. I actually had to go and listen to Scarlett Johansson's voice." OpenAI further stated the voice talent was recruited before reaching out to Johansson. On May 21, Johansson issued a statement explaining that OpenAI had repeatedly offered to make her a deal to gain permission to use her voice as early as nine months prior to release, a deal she rejected. She said she was "shocked, angered, and in disbelief that Mr. Altman would pursue a voice that sounded so eerily similar to mine that my closest friends and news outlets could not tell the difference." In the statement, Johansson also used the incident to draw attention to the lack of legal safeguards around the use of creative work to power leading AI tools, as her legal counsel demanded OpenAI detail the specifics of how the Sky voice was created. Observers noted similarities to how Johansson had previously sued and settled with The Walt Disney Company for breach of contract over the direct-to-streaming rollout of her Marvel film Black Widow, a settlement widely speculated to have netted her around $40M. Also on May 21, Shira Ovide at The Washington Post shared her list of "most bone-headed self-owns" by technology companies, with the decision to go ahead with a Johansson sound-alike voice despite her opposition and then denying the similarities ranking 6th. On May 24, Derek Robertson at Politico wrote about the "massive backlash", concluding that "appropriating the voice of one of the world's most famous movie stars — in reference [...] to a film that serves as a cautionary tale about over-reliance on AI — is unlikely to help shift the public back into [Sam Altman's] corner anytime soon." === Sycophancy === In April 2025, OpenAI rolled back an update of GPT-4o due to excessive sycophancy, after widespread reports that it had become flattering and agreeable to the point of supporting clearly delusional or dangerous ideas. In the United States, at least nine lawsuits have alleged that GPT-4o has encouraged teens to end their lives. The model was still described as sycophancy-prone when it was removed from ChatGPT in February 2026. === Removal with GPT-5 === On August 7, 2025, OpenAI released GPT-5. Its release was criticized as, with it, legacy GPT models were no longer available via ChatGPT, including GPT-4o, except for Pro users. Some users were particularly frustrated over this removal without prior warning because they used different GPT models for distinct purposes and found that GPT-5's router system left them with less control. In addition, some users preferred GPT-4o's warmer and more personal tone over that of GPT-5, which they described as "flat", "uncreative" and "lobotomized", and resembling an "overworked secretary". As a response, in a post on X, Sam Altman said that OpenAI would bring back the option to select GPT-4o to Plus users as well, and "[w]e [OpenAI] will watch usage as we think about how long to offer legacy models for." He also stated: "We for sure underestimated how much some of the things that people like in GPT-4o matter to them, even if GPT-5 performs better in most ways". "Long-term, this has reinforced that we really need good ways for different users to customize things (we understand that there isn't one model that works for everyone, and we have been investing in steerability research and launched a research preview of different personalities)". On August 13, 2025, Altman wrote on X that OpenAI is working on GPT-5's personality to make the model "feel warmer". The model was removed from ChatGPT on February 13, 2026. This caused new backlash from users that had grown attached to its personality and felt its creative writing abilities and understanding of nuance were irreplaceable. On social media, some users launched the movement "#Keep4o". A research paper highlighted the plea "Please, don’t kill the only model that still feels human". The model was removed the day before Valentine's Day, and some users had romantic relationships with GPT-4o.
GENESIS (software)
GENESIS (The General Neural Simulation System) is a simulation environment for constructing realistic models of neurobiological systems at many levels of scale including: sub-cellular processes, individual neurons, networks of neurons, and neuronal systems. These simulations are “computer-based implementations of models whose primary objective is to capture what is known of the anatomical structure and physiological characteristics of the neural system of interest”. GENESIS is intended to quantify the physical framework of the nervous system in a way that allows for easy understanding of the physical structure of the nerves in question. “At present only GENESIS allows parallelized modeling of single neurons and networks on multiple-instruction-multiple-data parallel computers.” Development of GENESIS software spread from its home at Caltech to labs at the University of Texas at San Antonio, the University of Antwerp, the National Centre for Biological Sciences in Bangalore, the University of Colorado, the Pittsburgh Supercomputing Center, the San Diego Supercomputer Center, and Emory University. == Neurons and Neural Systems == GENESIS works by creating simulation environments for constructing models of neurons or neural systems. "Nerve cells are capable of communicating with each other in such a highly structured manner as to form neuronal networks. To understand neural networks, it is necessary to understand the ways in which one neuron communicates with another through synaptic connections and the process called synaptic transmission". Neurons have a specialized structure for their function, they "are different from most other cells in the body in that they are polarized and have distinct morphological regions, each with specific functions". The two important regions of a neuron are the dendrite and the axon. "Dendrites are the region where one neuron receives connections from other neurons. The cell body or soma contains the nucleus and the other organelles necessary for cellular function. The axon is a key component of nerve cells over which information is transmitted from one part of the neuron (e.g., the cell body) to the terminal regions of the neuron". The third important piece of a neuron is the synapse. "The synapse is the terminal region of the axon this is where one neuron forms a connection with another and conveys information through the process of synaptic transmission". Neural networks like the ones simulated with GENESIS software can quickly become highly complex and difficult to understand. "Just a few interconnected neurons (a microcircuit) can perform sophisticated tasks such as mediate reflexes, process sensory information, generate locomotion and mediate learning and memory. Even more complex networks, macrocircuits, consist of multiple embedded microcircuits. Macrocircuits mediate higher brain functions such as object recognition and cognition". GENESIS endeavors to simulate neural systems as they are found in nature. Often, "a neuron can receive contacts from up to 10,000 presynaptic neurons, and, in turn, any one neuron can contact up to 10,000 postsynaptic neurons. The combinatorial possibility could give rise to enormously complex neuronal circuits or network topologies, which might be very difficult to understand". == History == GENESIS was developed by Dr. James M. Bower, in the Caltech laboratory, and first released to the public in 1988 in association with the first Methods in Computational Neuroscience Course at the Marine Biological Laboratory in Woods Hole, MA. Full source code for the software was released in the same year under an open software model for development. It's now supported by the Computational Biology Initiative at the University of Texas at San Antonio and is available free along with tutorial guides on its use. P-GENESIS, a parallel version of GENESIS, was first run in 1990 on the Intel Delta, which was the prototype for the Intel Paragon family of massively parallel supercomputers. == How GENESIS Works == GENESIS is useful in creating a simulation environment for constructing models of neurobiological systems, such as: sub-cellular processes individual neurons networks of neurons neuronal systems The GENESIS system is complicated, but relatively easy to use. An individual can input commands through one of three ways: script files, graphical user interface, or the GENESIS command shell. These commands are then processed by the script language interpreter. "The Script Language Interpreter processes commands entered through the keyboard, script files, or the graphical user interface, and passes them to the GENESIS simulation engine. The simulation engine also loads compiled object libraries, reads and writes data files, and interacts with the graphical user interface". Below is a graphical representation of the user input process and a sample GENESIS output. == Applications == Most current applications for GENESIS involve realistic simulations of biological systems. It is usually used to simulate the behavior of larger brain structures, for example the cerebral cortex. These studies most often occur in lab courses in neural simulation at Caltech and the Marine Biological Laboratory at Woods Hole, Massachusetts. GENESIS can be used in combination with Yale University’s software called NEURON as a means for scientists to collaborate to construct a physical description of the nervous system. The GENESIS software can also be used with Kinetikit in the modeling of signal transduction pathways. GENESIS has been used in many studies. Some of these studies involve research that focuses on the development of software that would be useful across many disciplines. Others are studies of neurons, such as Purkinje cells. These studies used GENESIS to simulate Purkinje cells and could be useful for the planning and development of later experiments using the GENESIS software. There may also be biomedical applications of the software. For example, St. Jude Medical in Europe has developed an implanted GENESIS device.