Shopping for the best AI clip maker? An AI clip maker is software that uses machine learning to help you get more done — it keeps getting smarter as the underlying models improve. Pricing, accuracy, and the size of the model behind the tool are the three factors that most affect daily usefulness. Whether you are a beginner or a pro, the right AI clip maker slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence.
MeituPic
Meitu Xiu Xiu ("Meitu") (Chinese: 美图秀秀) is an image editing software that is mostly used in Mainland China but is also popular in Hong Kong and Taiwan. It is only available on Google Play and App Store in certain countries. It provides tools for editing photos: filters, retouching, collage, scenes, frames, and photo decorations, as well as generative AI features such as text-to-images, AI removal and AI repainting etc. Meitu is one of the apps developed by Meitu, Inc.; it also produced BeautyCam, Wink and X-Design. == History == Meitu's PC version was created in 2008 by Wu Xinhong, the CEO of Meitu. In 2013, its mobile version became one of the first must-have mobile apps in China. Meitu, Inc. is a photo and video-centered app developer, which was founded in 2008 in Xiamen. Currently, the major revenue source of Meitu is premium subscription. Meitu, Inc. was initially funded by Cai Wensheng, a well-known angel investor. The company has an approximately 250 million monthly active users globally. == Function == === Edit === MeituPic provides a number of photo-editing tools. The major functions are auto enhance, edit, enhance, filters, frames, magic brush, mosaic, text, and blur. Auto enhance focuses on the nature of photos taken, while Edit includes functions of cropping, rotation, sharpening, and adjustment of ratio. For Enhance, users can apply slight adjustment on the photo by controlling the levels of brightness, contrast, colour temperature, saturation, highlight, shadow and smart light. Major types of filters are LOMO, beauty, style as well as art. Different frames can be chosen from poster, simple, and fantasy. Magic brush provides a great variety of brushes with different colours and patterns for users to decorate the photos. Mosaic brush enables users to cover certain parts of the photo. Texts can be added to the photo. Choices of different bubbles, font as well as style of words are available. Blurring effect is also available to make the photo less distinct and clear. === Beauty Retouch === There are seven major functions for retouching a photo: automatic retouch, smooth and whiten skin, remove blemish, make slimmer, remove dark circles and bags under the eyes, make taller, and enhance the eyes. Automatic retouch enhances portraits by lightening the skin tone, brightening the eyes, and simulating a face-lift by tapping on just one button. This helps to remove wrinkles and optimizes the skin tone. Acne, blemishes, and other skin imperfections can also be removed. The face-lift and weight-loss functions in the slimming option can be used to reshape the body. The option to make the subject taller can be used to change the perceived height of the subject and give the impression of slimmer, longer legs. The option to enhance the eyes can enlarge and brighten the eyes. === Collage === Collage has four types: template, freestyle, poster, PicStrip, which all maximize to insert nine photos. Template integrates photos in a vertical rectangle tightly. MeituPic has 15 frames or free download function for users. MeituPic also provides different templates according to number of photos inserted. Freestyle separates photos on a background freely. There are two parts of background: custom and more. For custom, users choose from album. For more, there are plain and picture with 18 choices. Poster makes a poster with photos. Users choose a poster among 8 choices or tap ‘more’ to download a new one. PicStrip combines photos vertically making an elongated file. Users choose a frame from 15 choices. Pinching thumb and forefinger together or apart zooms photos in/out. Putting two fingers and turning hand rotates photos. Pressing moves photos to ideal location. After designing, users tap ‘save/share’ on the upper right corner and the photo made is saved into album automatically. == Awards ==
Regulation of algorithms
Regulation of algorithms, or algorithmic regulation, is the creation of laws, rules and public sector policies for promotion and regulation of algorithms, particularly in artificial intelligence and machine learning. For the subset of AI algorithms, the term regulation of artificial intelligence is used. The regulatory and policy landscape for artificial intelligence (AI) is an emerging issue in jurisdictions globally, including in the European Union. Regulation of AI is considered necessary to both encourage AI and manage associated risks, but challenging. Another emerging topic is the regulation of blockchain algorithms (Use of the smart contracts must be regulated) and is mentioned along with regulation of AI algorithms. Many countries have enacted regulations of high frequency trades, which is shifting due to technological progress into the realm of AI algorithms. The motivation for regulation of algorithms is the apprehension of losing control over the algorithms, whose impact on human life increases. Multiple countries have already introduced regulations in case of automated credit score calculation—right to explanation is mandatory for those algorithms. For example, The IEEE has begun developing a new standard to explicitly address ethical issues and the values of potential future users. Bias, transparency, and ethics concerns have emerged with respect to the use of algorithms in diverse domains ranging from criminal justice to healthcare—many fear that artificial intelligence could replicate existing social inequalities along race, class, gender, and sexuality lines. == Regulation of artificial intelligence == === Public discussion === In 2016, Joy Buolamwini founded Algorithmic Justice League after a personal experience with biased facial detection software in order to raise awareness of the social implications of artificial intelligence through art and research. In 2017 Elon Musk advocated regulation of algorithms in the context of the existential risk from artificial general intelligence. According to NPR, the Tesla CEO was "clearly not thrilled" to be advocating for government scrutiny that could impact his own industry, but believed the risks of going completely without oversight are too high: "Normally the way regulations are set up is when a bunch of bad things happen, there's a public outcry, and after many years a regulatory agency is set up to regulate that industry. It takes forever. That, in the past, has been bad but not something which represented a fundamental risk to the existence of civilisation." In response, some politicians expressed skepticism about the wisdom of regulating a technology that is still in development. Responding both to Musk and to February 2017 proposals by European Union lawmakers to regulate AI and robotics, Intel CEO Brian Krzanich has argued that artificial intelligence is in its infancy and that it is too early to regulate the technology. Instead of trying to regulate the technology itself, some scholars suggest to rather develop common norms including requirements for the testing and transparency of algorithms, possibly in combination with some form of warranty. One suggestion has been for the development of a global governance board to regulate AI development. In 2020, the European Union published its draft strategy paper for promoting and regulating AI. Algorithmic tacit collusion is a legally dubious antitrust practise committed by means of algorithms, which the courts are not able to prosecute. This danger concerns scientists and regulators in EU, US and beyond. European Commissioner Margrethe Vestager mentioned an early example of algorithmic tacit collusion in her speech on "Algorithms and Collusion" on March 16, 2017, described as follows: "A few years ago, two companies were selling a textbook called The Making of a Fly. One of those sellers used an algorithm which essentially matched its rival’s price. That rival had an algorithm which always set a price 27% higher than the first. The result was that prices kept spiralling upwards, until finally someone noticed what was going on, and adjusted the price manually. By that time, the book was selling – or rather, not selling – for 23 million dollars a copy." In 2018, the Netherlands employed an algorithmic system SyRI (Systeem Risico Indicatie) to detect citizens perceived being high risk for committing welfare fraud, which quietly flagged thousands of people to investigators. This caused a public protest. The district court of Hague shut down SyRI referencing Article 8 of the European Convention on Human Rights (ECHR). In 2020, algorithms assigning exam grades to students in the UK sparked open protest under the banner "Fuck the algorithm." This protest was successful and the grades were taken back. In 2024, the Munich Convention on AI, Data and Human Rights was introduced as part of growing international efforts to regulate artificial intelligence through a human rights lens. Developed through a collaborative drafting process involving scholars from the Technical University of Munich, Stellenbosch University, Ulster University, and KNUST, the initiative calls for an international conversation on a binding treaty to safeguard human rights and the principles enshrined in the UN Charter in the age of AI. === Implementation === AI law and regulations can be divided into three main topics, namely governance of autonomous intelligence systems, responsibility and accountability for the systems, and privacy and safety issues. The development of public sector strategies for management and regulation of AI has been increasingly deemed necessary at the local, national, and international levels and in fields from public service management to law enforcement, the financial sector, robotics, the military, and international law. There are many concerns that there is not enough visibility and monitoring of AI in these sectors. In the United States financial sector, for example, there have been calls for the Consumer Financial Protection Bureau to more closely examine source code and algorithms when conducting audits of financial institutions' non-public data. In the United States, on January 7, 2019, following an Executive Order on 'Maintaining American Leadership in Artificial Intelligence', the White House's Office of Science and Technology Policy released a draft Guidance for Regulation of Artificial Intelligence Applications, which includes ten principles for United States agencies when deciding whether and how to regulate AI. In response, the National Institute of Standards and Technology has released a position paper, the National Security Commission on Artificial Intelligence has published an interim report, and the Defense Innovation Board has issued recommendations on the ethical use of AI. In April 2016, for the first time in more than two decades, the European Parliament adopted a set of comprehensive regulations for the collection, storage, and use of personal information, the General Data Protection Regulation (GDPR)1 (European Union, Parliament and Council 2016). The GDPR's policy on the right of citizens to receive an explanation for algorithmic decisions highlights the pressing importance of human interpretability in algorithm design. In 2016, China published a position paper questioning the adequacy of existing international law to address the eventuality of fully autonomous weapons, becoming the first permanent member of the U.N. Security Council to broach the issue, and leading to proposals for global regulation. In the United States, steering on regulating security-related AI is provided by the National Security Commission on Artificial Intelligence. In 2017, the U.K. Vehicle Technology and Aviation Bill imposes liability on the owner of an uninsured automated vehicle when driving itself and makes provisions for cases where the owner has made "unauthorized alterations" to the vehicle or failed to update its software. Further ethical issues arise when, e.g., a self-driving car swerves to avoid a pedestrian and causes a fatal accident. In 2021, the European Commission proposed the Artificial Intelligence Act. == Algorithm certification == There is a concept of algorithm certification emerging as a method of regulating algorithms. Algorithm certification involves auditing whether the algorithm used during the life cycle 1) conforms to the protocoled requirements (e.g., for correctness, completeness, consistency, and accuracy); 2) satisfies the standards, practices, and conventions; and 3) solves the right problem (e.g., correctly model physical laws), and satisfies the intended use and user needs in the operational environment. == Regulation of blockchain algorithms == Blockchain systems provide transparent and fixed records of transactions and hereby contradict the goal of the European GDPR, which is to give individuals full control of their private data. By implementing the Decree on Development of Digital Economy, Bel
DIKW pyramid
The DIKW pyramid (also known as the knowledge pyramid or information hierarchy) is a model describing relationships between data, information, knowledge and wisdom sometimes also stylized as a chain, refer to models of possible structural and functional relationships between a set of components—often four, data, information, knowledge, and wisdom. The concept has roots predating the 1980s. In the latter years of that decade, interest in the models grew after explicit presentations and discussions, including from Milan Zeleny, Russell Ackoff, and Robert W. Lucky. Subsequent important discussions extended along theoretical and practical lines into the coming decades. While debate continues as to actual meaning of the component terms of DIKW-type models, and the actual nature of their relationships—including occasional doubt being cast over any simple, linear, unidirectional model—even so they have become very popular visual representations in use by business, the military, and others. Among the academic and popular, not all versions of the DIKW-type models include all four components (earlier ones excluding data, later ones excluding or downplaying wisdom, and several including additional components (for instance Ackoff inserting "understanding" before and Zeleny adding "enlightenment" after the wisdom component). In addition, DIKW-type models are no longer always presented as pyramids, instead also as a chart or framework (e.g., by Zeleny), as flow diagrams (e.g., by Liew, and by Chisholm et al.), and sometimes as a continuum (e.g., by Choo et al.). == Short description == As Rowley noted in 2007, the DIKW model "is often quoted, or used implicitly, in definitions of data, information and knowledge in the information management, information systems and knowledge management literatures, but [as of that date] there ha[d] been limited direct discussion of the hierarchy". Reviews of textbooks and a survey of scholars in relevant fields indicate that there was not a consensus as to definitions used in the model as of that date, and as reviewed by Liew in that year, even less "in the description of the processes that transform components lower in the hierarchy into those above them". Zins work, published in 2007—from studies in 2003-2005 that documented "130 definitions of data, information, and knowledge formulated by 45 scholars", published in 2007—to suggest that the data–information–knowledge components of DIKW refer to a class of no less than five models, as a function of whether data, information, and knowledge are each conceived of as subjective, objective (what Zins terms, "universal" or "collective") or both. In Zins' usage, subjective and objective "are not related to arbitrariness and truthfulness, which are usually attached to the concepts of subjective knowledge and objective knowledge". Information science, Zins argues, studies data and information, but not knowledge, as knowledge is an internal (subjective) rather than an external (universal–collective) phenomenon. == Representations == === Graphical representation === DIKW is a hierarchical model often depicted as a pyramid, sometimes as a chain, with data at its base and wisdom at its apex (or chain-beginning and -end). Both Zeleny and Ackoff have been credited with originating the pyramid representation, although neither used a pyramid to present their ideas. According to Wallace, Debons and colleagues may have been the first to "present the hierarchy graphically". Many variations of the DIKW-type pyramid have been produced. One, in use by knowledge managers in the United States Department of Defense, attempts to show the DIKW progression to enable effective decisions and consequent activities supporting shared understanding throughout defense organizations, as well as supporting management of risks associated with decisions. DIKW-type hierarchical information paradigms have also been represented as two-dimensional charts, and as flow diagrams, where relationships between the components may be presented less hierarchically, with defining aspects of the relationships, feedback loops, etc. === Computational representation === Intelligent decision support systems are trying to improve decision making by introducing new technologies and methods from the domain of modeling and simulation in general, and in particular from the domain of intelligent software agents in the contexts of agent-based modeling. The following example describes a military decision support system, but the architecture and underlying conceptual idea are transferable to other application domains: The value chain starts with data quality describing the information within the underlying command and control systems. Information quality tracks the completeness, correctness, currency, consistency and precision of the data items and information statements available. Knowledge quality deals with procedural knowledge and information embedded in the command and control system such as templates for adversary forces, assumptions about entities such as ranges and weapons, and doctrinal assumptions, often coded as rules. Awareness quality measures the degree of using the information and knowledge embedded within the command and control system. Awareness is explicitly placed in the cognitive domain. By the introduction of a common operational picture, data are put into context, which leads to information instead of data. The next step, which is enabled by service-oriented web-based infrastructures (but not yet operationally used), is the use of models and simulations for decision support. Simulation systems are the prototype for procedural knowledge, which is the basis for knowledge quality. Finally, using intelligent software agents to continually observe the battle sphere, apply models and simulations to analyze what is going on, to monitor the execution of a plan, and to do all the tasks necessary to make the decision maker aware of what is going on, command and control systems could even support situational awareness, the level in the value chain traditionally limited to pure cognitive methods. == History == Danny P. Wallace, a professor of library and information science, explained that the origin of the DIKW pyramid is uncertain: The presentation of the relationships among data, information, knowledge, and sometimes wisdom in a hierarchical arrangement has been part of the language of information science for many years. Although it is uncertain when and by whom those relationships were first presented, the ubiquity of the notion of a hierarchy is embedded in the use of the acronym DIKW as a shorthand representation for the data-to-information-to-knowledge-to-wisdom transformation.Many authors think that the idea of the DIKW relationship originated from two lines in the poem "Choruses", by T. S. Eliot, that appeared in the pageant play The Rock, in 1934: === Knowledge, intelligence, and wisdom === In 1927, Clarence W. Barron addressed his employees at Dow Jones & Company on the hierarchy: "Knowledge, Intelligence and Wisdom". === Data, information, knowledge === In 1955, English-American economist and educator Kenneth Boulding presented a variation on the hierarchy consisting of "signals, messages, information, and knowledge". However, "[t]he first author to distinguish among data, information, and knowledge and to also employ the term 'knowledge management' may have been American educator Nicholas L. Henry", in a 1974 journal article. === Data, information, knowledge, wisdom === Other early versions (prior to 1982) of the hierarchy that refer to a data tier include those of Chinese-American geographer Yi-Fu Tuan and sociologist-historian Daniel Bell.. In 1980, Irish-born engineer Mike Cooley invoked the same hierarchy in his critique of automation and computerization, in his book Architect or Bee?: The Human / Technology Relationship. Thereafter, in 1987, Czechoslovakia-born educator Milan Zeleny mapped the components of the hierarchy to knowledge forms: know-nothing, know-what, know-how, and know-why. Zeleny "has frequently been credited with proposing the [representation of DIKW as a pyramid ]... although he actually made no reference to any such graphical model." The hierarchy appears again in a 1988 address to the International Society for General Systems Research, by American organizational theorist Russell Ackoff, published in 1989. Subsequent authors and textbooks cite Ackoff's as the "original articulation" of the hierarchy or otherwise credit Ackoff with its proposal. Ackoff's version of the model includes an understanding tier (as Adler had, before him), interposed between knowledge and wisdom. Although Ackoff did not present the hierarchy graphically, he has also been credited with its representation as a pyramid. In 1989, Bell Labs veteran Robert W. Lucky wrote about the four-tier "information hierarchy" in the form of a pyramid in his book Silicon Dreams. In the same year as Ackoff presented his a
Artificial intelligence in architecture
Artificial intelligence in architecture is the use of artificial intelligence in automation, design, and planning in the architectural process or in assisting human skills in the field of architecture. AI has been used by some architects for design, and has been proposed as a way to automate planning and routine tasks in the field. == Implications == === Benefits === Artificial intelligence, according to ArchDaily, is said to potentially significantly augment the architectural profession through its ability to improve the design and planning process as well as increasing productivity. Through its ability to handle a large amount of data, AI is said to potentially allow architects a range of design choices with criteria considerations such as budget, requirements adjusted to space, and sustainability goals calculated as part of the design process. ArchDaily said this may allow the design of optimized alternatives that can then undergo human review. AI tools are also said to potentially allow architects to assimilate urban and environmental data to inform their designs, streamlining initial stages of project planning and increasing efficiency and productivity. The advances in generative design through the input of specific prompts allow architects to produce visual designs, including photorealistic images, and thus render and explore various material choices and spatial configurations. ArchDaily noted this could speed the creative process as well as allow for experimentation and sophistication in the design. Additionally, AI's capacity for pattern recognition and coding could aid architects in organizing design resources and developing custom applications, thus enhancing the efficiency and collaboration between both architects and AI. AI is thought to also be able to contribute to the sustainability of buildings by analyzing various factors and following recommended energy-efficient modifications, thus pushing the industry towards greener practices. The use of AI in building maintenance, project management, and the creation of immersive virtual reality experiences are also thought of as potentially augmenting the architectural design process and workflow. Examples include the use of text-to-image systems such as Midjourney to create detailed architectural images, and the use of AI optimization systems from companies such as Finch3D and Autodesk to automatically generate floor plans from simple programmatic inputs. In contrast to digital-only creative practices, the high materiality of architectural outputs requires transitions from ephemeral digital files to permanent physical structures that are subject to strict safety regulations, material constraints, sensory intuition, and site-specific cultural contexts, making full automation difficult. Early adopters such as architect Stephen Coorlas have actively challenged the boundaries of architectural practice through AI. His early experimental initiative, Speculations on AI and Architecture, confronts the discipline's traditional workflows by training text-to-image AI tools such as Midjourney, Luma AI, and PromeAI to generate more nuanced architectural illustrations including construction documents, architectural details, and assembly sequences for various structures. Coorlas inputs precise terminology and architectural language to provoke the AI into producing axonometric drawings that resemble conventional documentation, then experiments with animating the outputs using AI generated depth maps and other AI image-to-3D wireframe tools. Stephen's inventive process invites architects and designers to reconsider authorship, automation, and the future of visual communication in the built environment. Rather than treating AI as a peripheral tool, Stephen has advocated for AI to be a speculative collaborator capable of engaging with discipline-specific challenges. His work contributes to the growing discourse on generative design, parametric optimization, and the philosophical implications of machine-assisted creativity raising urgent questions about how such technologies will reshape architectural agency, precision, and pedagogy. Another prominent advocate is Architect Andrew Kudless, who in an interview to Dezeen recounted that he uses AI to innovate in architectural design by incorporating materials and scenes not usually present in initial plans, which he believes can significantly alter client presentations. He told Dezeen he believes one should show clients renderings from the onset, with AI assisting in this work, arguing that changes in design should be a positive aspect of the client-designer relationship by actively involving clients in the process. Additionally, Kudless highlighted the AI's potential to facilitate labor in architectural firms, particularly in automating rendering tasks, thus reducing the workload on junior staff while maintaining control over the creative output. === Emergent aesthetics === In an interview for the AItopia series to Dezeen, designer Tim Fu discussed the transformative potential of AI in architecture, and proposed a future where AI could herald a "neoclassical futurist" style, blending the grandeur of classical aesthetics with futuristic design. Through his collaborative project, The AI Stone Carver, Fu showcased how AI can innovate traditional practices by generating design concepts that are then realized through human craftsmanship, such as stone carving by mason Till Apfel. This approach, he believed, celebrated the fusion of diverse architectural styles and also emphasized the unique capabilities of AI in enhancing creative design processes. Fu told Dezeen he envisions the integration of AI in design as a means to revive the ornamentation and detailed aesthetics characteristic of classical architecture, moving away from minimalism, which he said dominates contemporary architecture. He argued that AI's involvement in the ideation phase of design allows for a reversal in the roles of machine and human, enabling architects and designers to focus on creating more intricate and ornamental structures. Fu's optimistic outlook extended to the broader impact of AI on the architectural field, seeing it as an indispensable tool that will shift rather than replace human roles, enriching the field with innovative designs that pay homage to the beauty and qualities of classical architecture not present in contemporary architecture while embracing new technologies. This perspective resonates with designers like Manas Bhatia, whose explorations similarly embrace generative AI as a co-creator and a medium to express ideas, blend architectural traditions, and speculate spatial futures. === Concerns === As AI continues to expand its presence across various industries, its impact on the architectural profession has become a topic of growing discussion. These discussions focus on how AI processes may influence traditional architectural practices, potentially altering job roles, and shaping the nature of creativity. While AI-driven processes may increase efficiency in some aspects of the profession, they also raise questions about the potential loss of unique design perspectives. These thoughts have been countered by many prominent creative figures in the realm of AI architecture, such as Stephen Coorlas, Tim Fu, Hassan Ragab, and Manas Bhatia who have showcased the amplification of creativity in design and potential benefits in terms of restoring creative power to the designer. A key concern is that AI-powered tools could diminish the need for human involvement in specific tasks traditionally performed by architects. This has led to speculation that the profession may increasingly shift toward roles focused on oversight, coordination, and strategic decision-making rather than hands-on design work. In some design scenarios, algorithmically generated solutions can be adjusted to prioritize efficiency and cost-effectiveness, which some argue may overshadow the creative and contextual nuances that define individual architectural styles. As with any discipline though, it has been determined that AI can be configured to provide beneficial results based on inputs and end goals the architect or designer assigns it. There are also concerns about the potential for AI to exacerbate inequalities within the architectural profession. For instance, larger firms with greater resources to invest in advanced AI technologies may gain a competitive edge over smaller firms and independent architects. This dynamic could contribute to industry consolidation, potentially limiting the diversity of architectural practice and stifling innovation. Ethical considerations in regard to cultural sensitivity have also been raised due to the datasets used to train AI. Without proper vetting of data or implementing failsafe overrides, AI generated outcomes can trend toward overly documented and prioritized content.
Microscope image processing
Microscope image processing is a broad term that covers the use of digital image processing techniques to process, analyze and present images obtained from a microscope. Such processing is now commonplace in a number of diverse fields such as medicine, biological research, cancer research, drug testing, metallurgy, etc. A number of manufacturers of microscopes now specifically design in features that allow the microscopes to interface to an image processing system. == Image acquisition == Until the early 1990s, most image acquisition in video microscopy applications was typically done with an analog video camera, often simply closed circuit TV cameras. While this required the use of a frame grabber to digitize the images, video cameras provided images at full video frame rate (25-30 frames per second) allowing live video recording and processing. While the advent of solid state detectors yielded several advantages, the real-time video camera was actually superior in many respects. Today, acquisition is usually done using a CCD camera mounted in the optical path of the microscope. The camera may be full colour or monochrome. Very often, very high resolution cameras are employed to gain as much direct information as possible. Cryogenic cooling is also common, to minimise noise. Often digital cameras used for this application provide pixel intensity data to a resolution of 12-16 bits, much higher than is used in consumer imaging products. Ironically, in recent years, much effort has been put into acquiring data at video rates, or higher (25-30 frames per second or higher). What was once easy with off-the-shelf video cameras now requires special, high speed electronics to handle the vast digital data bandwidth. Higher speed acquisition allows dynamic processes to be observed in real time, or stored for later playback and analysis. Combined with the high image resolution, this approach can generate vast quantities of raw data, which can be a challenge to deal with, even with a modern computer system. While current CCD detectors allow very high image resolution, often this involves a trade-off because, for a given chip size, as the pixel count increases, the pixel size decreases. As the pixels get smaller, their well depth decreases, reducing the number of electrons that can be stored. In turn, this results in a poorer signal-to-noise ratio. For best results, one must select an appropriate sensor for a given application. Because microscope images have an intrinsic limiting resolution, it often makes little sense to use a noisy, high resolution detector for image acquisition. A more modest detector, with larger pixels, can often produce much higher quality images because of reduced noise. This is especially important in low-light applications such as fluorescence microscopy. Moreover, one must also consider the temporal resolution requirements of the application. A lower resolution detector will often have a significantly higher acquisition rate, permitting the observation of faster events. Conversely, if the observed object is motionless, one may wish to acquire images at the highest possible spatial resolution without regard to the time required to acquire a single image. == 2D image techniques == Image processing for microscopy application begins with fundamental techniques intended to most accurately reproduce the information contained in the microscopic sample. This might include adjusting the brightness and contrast of the image, averaging images to reduce image noise and correcting for illumination non-uniformities. Such processing involves only basic arithmetic operations between images (i.e. addition, subtraction, multiplication and division). The vast majority of processing done on microscope image is of this nature. Another class of common 2D operations called image convolution are often used to reduce or enhance image details. Such "blurring" and "sharpening" algorithms in most programs work by altering a pixel's value based on a weighted sum of that and the surrounding pixels (a more detailed description of kernel based convolution deserves an entry for itself) or by altering the frequency domain function of the image using Fourier Transform. Most image processing techniques are performed in the Frequency domain. Other basic two dimensional techniques include operations such as image rotation, warping, color balancing etc. At times, advanced techniques are employed with the goal of "undoing" the distortion of the optical path of the microscope, thus eliminating distortions and blurring caused by the instrumentation. This process is called deconvolution, and a variety of algorithms have been developed, some of great mathematical complexity. The end result is an image far sharper and clearer than could be obtained in the optical domain alone. This is typically a 3-dimensional operation, that analyzes a volumetric image (i.e. images taken at a variety of focal planes through the sample) and uses this data to reconstruct a more accurate 3-dimensional image. == 3D image techniques == Another common requirement is to take a series of images at a fixed position, but at different focal depths. Since most microscopic samples are essentially transparent, and the depth of field of the focused sample is exceptionally narrow, it is possible to capture images "through" a three-dimensional object using 2D equipment like confocal microscopes. Software is then able to reconstruct a 3D model of the original sample which may be manipulated appropriately. The processing turns a 2D instrument into a 3D instrument, which would not otherwise exist. In recent times this technique has led to a number of scientific discoveries in cell biology. == Analysis == Analysis of images will vary considerably according to application. Typical analysis includes determining where the edges of an object are, counting similar objects, calculating the area, perimeter length and other useful measurements of each object. A common approach is to create an image mask which only includes pixels that match certain criteria, then perform simpler scanning operations on the resulting mask. It is also possible to label objects and track their motion over a series of frames in a video sequence.
BRS/Search
BRS/Search is a full-text database and information retrieval system. BRS/Search uses a fully inverted indexing system to store, locate, and retrieve unstructured data. It was the search engine that in 1977 powered Bibliographic Retrieval Services (BRS) commercial operations with 20 databases (including the first national commercial availability of MEDLINE); it has changed ownership several times during its development and is currently sold as Livelink ECM Discovery Server by Open Text Corporation. == Early development == Development on what was to become BRS began as Biomedical Communications Network (BCN) at the State University of New York at Albany (SUNY). BCN, which went online in 1968, provided on-line access to nine databases, including MEDLINE and BIOSIS Previews, to large universities and medical schools primarily in the Northeast of the USA. State funding for the project was withdrawn in 1975, and Bibliographic Retrieval Services (BRS) was formed as a non-profit concern the following year. It was incorporated in May 1976 as a for-profit corporation with Ron Quake as president, Jan Egeland as vice president in charge of marketing and training, and Lloyd Palmer as vice president of systems. == BRS commercial operations == In December 1976, the First BRS User Meeting was held in Syracuse, New York, and by January 1977 BRS started commercial operations with 20 databases (including the first national commercial availability of MEDLINE) and 9 million records, using modified IBM STAIRS (STorage And Information Retrieval System) software, Telenet for telecommunications, and timesharing mainframe computers of Carrier Corporation. In October 1980 BRS was sold by Egeland and Quake to Indian Head, Inc., a subsidiary of the Dutch company Thyssen-Bornemisza Group. == 1989–1993 == In 1989 Robert Maxwell acquired BRS and the BRS/Search software; he announced the planned incorporation of the ORBIT Search Service and BRS Information Technologies and renamed the whole group Maxwell Online, Inc. At that time BRS Information Technologies was serving the medical and academic library marketplace with over 150 databases. Maxwell later bought the publishing company Macmillan and put Maxwell Online under Macmillan. In the same year BRS/LINK (hypertext connection of databases; first application delivering full text) was announced. The initial BRS/LINK application "relates the citation in a bibliographic database to its full-text article in a second database," and "eliminates the need to re-execute a search strategy in the second database in order to find the corresponding full-text article." Initially BRS/LINK supported linking only selected bibliographic databases: MEDLINE, Health Planning and Administration, and MEDLINE References on AIDS to the full-text Comprehensive Core Medical Library. At the time of Robert Maxwell’s death in 1991, Macmillan brought in Andrew Gregory to represent the company during the 2 years that Maxwell’s affairs were being settled and to prepare Maxwell Online to be able to sell the components. Maxwell Online shortly thereafter underwent yet another name change, this time to InfoPro Technologies. == Dataware Technologies ownership of BRS/SEARCH == Early in 1994, InfoPro Technologies, a subsidiary of MHC Inc. (holding company for Macmillan Inc.), the former Maxwell Online service, sold off all its subsidiaries. ORBIT Search Services went to the French-owned Questel, the dial-up BRS Search Services to CD Plus Technologies (later to become OVID), and BRS Software Products (including BRS/SEARCH) to Dataware Technologies. Almost up to the end of InfoPro Technologies, BRS Software had been the fastest growing segment of the company. At the 14th BRS North American Users Group Conference in 1999, Dave Schubmehl of Dataware Technologies presented a paper in which he stated "The purpose of this presentation is to update BRS users on upcoming releases of BRS/Search, NetAnswer, and other Dataware products. BRS/Search 7.0 will include features specifically requested by customers, as well as other enhancements. Earlier this year, Dataware acquired Sovereign Hill Software, makers of InQuery. In light of that acquisition, and Dataware's other development projects, we'll look at Dataware's plans for all products, including BRS/Search and NetAnswer." == Open Text acquisition of BRS/Search == In 2001 BRS/Search was acquired by Open Text and became LiveLink ECM Discovery Server. It is now referred to as Open Text Discovery Server. Open Text still supports both BRS/Search and NetAnswer. The core BRS/Search technology in the Open Text portfolio was augmented with other capabilities through various acquisitions. For example, Dataware's acquisition of Sovereign-Hill brought InQuery, “a probabilistic information retrieval system using an inference network”, which was developed by the University of Massachusetts Amherst Center for Intelligent Information Retrieval] out of the UMass CIIR and into the marketplace. A product re-branding table shows the range of products, their old names and their new names. InQuery is a concept search engine that uses noun phrases, parts of speech and other co-occurrence relationships in overlapping passages of text rather than single term inverted indexes of single words in documents. Open Text's portfolio has grown to include Hummingbird Content Management, and has always included BASIS. == 2003 == BRS/Search North America User's Group (BRSNAUG) website with a June 8, 2003 date listed the following features for BRS/Search. The BRSNAUG also disincorporated in 2003. Cross-references to BRS/Search on the World Wide Web point to Open Text Livelink. Engine features include: Rapid query response time. Numerical data handling and elementary statistical processing (sum, avg, min, max) Search results weighting and relevancy ranking Left- and right-truncation and expansion of search terms Superior data compression – loaded databases typically use only about 1.5 times the input stream size in disk space Large capacity databases – up to 100 million documents, each with up to 65,000 paragraphs Fine control of indexing and searching – right down to the word, sentence, and paragraph level Fine control over data security. Document access can be controlled at the database, document, and paragraph level International language support for all 7/8 bit characters sets and customizable language tables Flexible and customizable stop word lists ANSI-compatible thesauri Hypertext links within and between documents and databases (R6.x) Support for natural language parsing of queries Automatic document summarization tools Client/Server development Programming interfaces for World-Wide Web (HTTP, HTML) access to databases