The Shapiro—Senapathy algorithm (S&S) is a computational method for identifying splice sites in eukaryotic genes. The algorithm employs a Position Weight Matrix (PWM) scoring formula to predict donor and acceptor splice sites in any given gene. This methodology has been used to discover splice sites and disease-causing splice site mutations in the human genome, and has become a standard tool in clinical genomics. The S&S algorithm has been cited in thousands of clinical studies, according to Google Scholar. It has also formed the basis of widely used software, including Human Splicing Finder, SROOGLE, and Alamut, which identify splice sites and splice site mutations that cause disease. The algorithm has uncovered splicing mutations in diseases ranging from cancers to inherited disorders, and predicted the deleterious effects of these mutations including exon skipping, intron retention, and cryptic splice site activation. == The algorithm == A splice site defines the boundary between a coding exon and a non-coding intron in eukaryotic genes. The S&S algorithm employs a sliding window, corresponding to the length of the splice site motif, to scan a gene sequence and detect potential splice sites. For each sliding window, the algorithm calculates a score by comparing the nucleotide sequence to a Position Weight Matrix (PWM) derived from known splice sites. This formula generates a percentile score, indicating the likelihood that a given sequence functions as a donor or acceptor splice site. The majority of disease-causing mutations in the human genome are located in splice sites. Clinical genomics studies analyze the splice site scores generated by the S&S algorithm to predict the consequences of splice site mutations including exon skipping and intron retention. The algorithm's sensitivity to single-nucleotide changes allows it to determine mutations that may impact RNA splicing and contribute to disease. In addition to identifying real splice sites, the S&S algorithm has been used to discover cryptic splice sites — alternative splice sites activated by mutations — which may disrupt normal splicing. The algorithm detects mutations that lead to the activation of cryptic splice sites, which may be located proximal to real splice sites or deep within non-coding introns. It has thus been used to determine the causes of numerous diseases that are due to cryptic splicing. == Cancer gene discovery using S&S == The S&S algorithm has been used to identify splice-site mutations in genes associated with several cancers. For example, genes causing commonly occurring cancers including breast cancer, ovarian cancer, colorectal cancer, leukemia, head and neck cancers, prostate cancer, retinoblastoma, squamous cell carcinoma, gastrointestinal cancer, melanoma, liver cancer, Lynch syndrome, skin cancer, and neurofibromatosis have been found. In addition, splicing mutations in genes causing less commonly known cancers including gastric cancer, gangliogliomas, Li-Fraumeni syndrome, Loeys–Dietz syndrome, Osteochondromas (bone tumor), Nevoid basal cell carcinoma syndrome, and Pheochromocytomas have been identified. Specific mutations in different splice sites in various genes causing breast cancer (e.g., BRCA1, PALB2), ovarian cancer (e.g., SLC9A3R1, COL7A1, HSD17B7), colon cancer (e.g., APC, MLH1, DPYD), colorectal cancer (e.g., COL3A1, APC, HLA-A), skin cancer (e.g., COL17A1, XPA, POLH), and Fanconi anemia (e.g., FANC, FANA) have been uncovered. The mutations in the donor and acceptor splice sites in different genes causing a variety of cancers that have been identified by S&S are shown in Table 1. == Discovery of genes causing inherited disorders using S&S == Specific mutations in different splice sites in various genes that cause inherited disorders, including, for example, Type 1 diabetes (e.g., PTPN22, TCF1 (HCF-1A)), hypertension (e.g., LDL, LDLR, LPL), Marfan syndrome (e.g., FBN1, TGFBR2, FBN2), cardiac diseases (e.g., COL1A2, MYBPC3, ACTC1), eye disorders (e.g., EVC, VSX1) have been uncovered. A few example mutations in the donor and acceptor splice sites in different genes causing a variety of inherited disorders identified using S&S are shown in Table 2. == Genes causing immune system disorders == More than 100 immune system disorders affect humans, including inflammatory bowel diseases, multiple sclerosis, systemic lupus erythematosus, bloom syndrome, familial cold autoinflammatory syndrome, and dyskeratosis congenita. The Shapiro–Senapathy algorithm has been used to discover genes and mutations involved in many immune disorder diseases, including Ataxia telangiectasia, B-cell defects, epidermolysis bullosa, and X-linked agammaglobulinemia. Xeroderma pigmentosum, an autosomal recessive disorder is caused by faulty proteins formed due to new preferred splice donor site identified using S&S algorithm and resulted in defective nucleotide excision repair. Type I Bartter syndrome (BS) is caused by mutations in the gene SLC12A1. S&S algorithm helped in disclosing the presence of two novel heterozygous mutations c.724 + 4A > G in intron 5 and c.2095delG in intron 16 leading to complete exon 5 skipping. Mutations in the MYH gene, which is responsible for removing the oxidatively damaged DNA lesion are cancer-susceptible in the individuals. The IVS1+5C plays a causative role in the activation of a cryptic splice donor site and the alternative splicing in intron 1, S&S algorithm shows, guanine (G) at the position of IVS+5 is well conserved (at the frequency of 84%) among primates. This also supported the fact that the G/C SNP in the conserved splice junction of the MYH gene causes the alternative splicing of intron 1 of the β type transcript. Splice site scores were calculated according to S&S to find EBV infection in X-linked lymphoproliferative disease. Identification of Familial tumoral calcinosis (FTC) is an autosomal recessive disorder characterized by ectopic calcifications and elevated serum phosphate levels and it is because of aberrant splicing. == Application of S&S in hospitals for clinical practice and research == The Shapiro–Senapathy (S&S) algorithm has played a significant role in advancing the diagnosis and treatment of human diseases through its application in modern clinical genomics. With the widespread adoption of next-generation sequencing (NGS) technologies, the S&S algorithm is now routinely integrated into clinical practice by geneticists and diagnostic laboratories. It is implemented in various computational tools such as Human Splicing Finder (HSF), Splice Site Finder (SSF), and Alamut Visual, which assist in interpreting the functional impact of genetic variants on RNA splicing. The algorithm is particularly useful in identifying pathogenic splice site mutations in cases where the clinical presentation is unclear or where conventional diagnostic methods have failed to identify a causative gene. Its utility has been demonstrated across diverse patient cohorts, including individuals from different ethnic backgrounds with various cancers and inherited genetic disorders. The following are selected examples illustrating its application in clinical research. === Cancers === === Inherited disorders === == S&S - Algorithm for identifying splice sites, exons and split genes == The Shapiro–Senapathy algorithm (SSA) was developed to identify splice sites in uncharacterized genomic sequences, with early applications in the Human Genome Project. The method introduced a Position Weight Matrix (PWM)-based approach to analyze splicing sequences across eukaryotic organisms, marking the first computational framework to systematically define splice sites using probabilistic scoring. Key innovations of the algorithm included: Exon Detection – Exons were defined as sequences bounded by acceptor and donor splice sites with S&S scores above a threshold, requiring an open reading frame (ORF) for validation. Gene Prediction – The method enabled the identification of complete genes by assembling predicted exons, forming a basis for later gene-finding tools. Mutation Analysis – The algorithm distinguishes deleterious splice-site mutations (which disrupt protein function by lowering S&S scores) from neutral variations. This capability allowed researchers to study disease-linked cryptic splice sites in humans, animals, and plants. SSA's PWM-based framework influenced subsequent computational methods, including machine learning and neural network approaches, for splice-site prediction and alternative splicing research. It remains a foundational tool in genomics and disease studies. == Discovering the mechanisms of aberrant splicing in diseases == The Shapiro–Senapathy algorithm has been used to determine the various aberrant splicing mechanisms in genes due to deleterious mutations in the splice sites, which cause numerous diseases. Deleterious splice site mutations impair the normal splicing of the gene transcripts, and thereby make the encoded protei
Telligent Community
Telligent Community is a community and collaboration software platform developed by Telligent Systems and was first released in 2004. Telligent Community is built on the Telligent Evolution platform, with a variety of core applications running on top of it such as blogs, forums, media galleries, and wikis. Additional applications from third parties using the API's and REST stack can be installed or integrated with the platform. Telligent Community is built with ASP.NET, C#, and Microsoft SQL Server. It is available as downloadable software that can be installed on a web server or via hosting providers. The current version is Verint Community 12.0 which was released February 2012. The product used to be named Community Server before being rebranded as part of the 5.0 release. == History == Telligent Systems was founded by Rob Howard in 2004, who was previously part of Microsoft's ASP.NET team. Telligent introduced its first product, Community Server, in the fall of 2004. Community Server was one of the first integrated community platforms that brought together blogs, photo galleries, wikis, forums, user profiles and more. Community Server was based on the merger of three then-widely used open source ASP.NET projects: the ASP.NET Forums, nGallery photo gallery, and .Text blog engine. The people behind those projects (Scott Watermasysk, Jason Alexander, and Rob Howard) joined together as Telligent Systems and along with several other software developers created Community Server 1.0. Between 2004 and 2009 Community Server steadily grew in scope, features, and capabilities. In 2008 Telligent Systems released a second version of Community Server that targeted as an Enterprise Social Software platform used to create and manage internal employee communities and intranets. Originally branded as Community Server Evolution this was later renamed Telligent Enterprise. Telligent also announced a new Enterprise Reporting platform at its first Community Server Developers Conference in 2008, which was later renamed Harvest. It was one of the first analytics suites for enterprise collaboration software, and provides social analytics including sentiment analysis, social fingerprints, and buzz analysis on social networking sites such as Twitter. Telligent rebranded all of its products on June 23, 2009 at the Enterprise 2.0 conference when it launched its new Evolution platform product suite. Community Server became known as Telligent Community, Community Server Evolution became known as Telligent Enterprise and the underlying platform that both run on is now referred to as Telligent Evolution. The Social Analytics suite was renamed Telligent Analytics.
Death of Elaine Herzberg
The death of Elaine Herzberg (August 2, 1968 – March 18, 2018) was the first recorded case of a pedestrian fatality involving a self-driving car, after a collision that occurred late in the evening of March 18, 2018. Herzberg was pushing a bicycle across a four-lane road in Tempe, Arizona, United States, when she was struck by an Uber test vehicle, which was operating in self-drive mode with a human safety backup driver sitting in the driving seat. Herzberg was taken to the local hospital where she died of her injuries. Following the fatal incident, the National Transportation Safety Board (NTSB) issued a series of recommendations and sharply criticized Uber. The company suspended testing of self-driving vehicles in Arizona, where such testing had been approved since August 2016. Uber chose not to renew its permit for testing self-driving vehicles in California when it expired at the end of March 2018. Uber resumed testing in December 2018, starting in Pittsburgh, Pennsylvania. In March 2019, Arizona prosecutors ruled that Uber was not criminally responsible for the crash. The back-up driver of the vehicle was charged with negligent homicide, pled guilty to endangerment, and was sentenced to three years' probation. While Herzberg was the first pedestrian killed by a self-driving car, driver Gao Yaning died in a Tesla semi-autonomous car two years earlier. A reporter for The Washington Post compared Herzberg's fate with that of Bridget Driscoll who, in the United Kingdom in 1896, was the first pedestrian to be killed by an automobile. The Arizona incident has magnified the importance of collision avoidance systems for self-driving vehicles. == Collision summary == Herzberg was crossing Mill Avenue (North) from west to east, approximately 360 feet (110 m) south of the intersection with Curry Road, outside the designated pedestrian crosswalk, close to the Red Mountain Freeway. She was pushing a bicycle laden with shopping bags, and had crossed at least two lanes of traffic when she was struck at approximately 9:58 pm MST (UTC−07:00) by a prototype Uber self-driving car based on a Volvo XC90, which was traveling north on Mill. The vehicle had been operating in autonomous mode since 9:39 pm, nineteen minutes before it struck and killed Herzberg. The car's human safety backup driver, Rafaela Vasquez, did not intervene in time to prevent the collision. Vehicle telemetry obtained after the crash showed that the human operator responded by moving the steering wheel less than a second before impact, and she engaged the brakes less than a second after impact. == Cause investigation == The county district attorney's office recused itself from the investigation, due to a prior joint partnership with Uber promoting their services as an alternative to driving under the influence of alcohol. Accounts differ on the speed limit at the place of the incident. According to Tempe police the car was traveling in a 35 mph (56 km/h) zone, but this is contradicted by a posted speed limit of 45 mph (72 km/h). The National Transportation Safety Board (NTSB) sent a team of federal investigators to gather data from vehicle instruments, and to examine vehicle condition along with the actions taken by the safety driver. Their preliminary findings were substantiated by multiple event data recorders and proved the vehicle was traveling 43 miles per hour (69 km/h) when Herzberg was first detected 6 seconds (378 feet (115 m)) before impact; during 4.7 seconds the self driving system did not infer that emergency braking was needed. A vehicle traveling 43 mph (69 km/h) can generally stop within 89 feet (27 m) once the brakes are applied. The machine needed to be 1.3 seconds (82 feet (25 m)) away prior to discerning that emergency braking was required, whereas at least that much distance was required to stop. The system failed to behave properly. A total stopping distance of 76 feet itself would imply a safe speed under 25 mph (40 km/h). Human intervention was still legally required. Computer perception–reaction time would have been a speed limiting factor had the technology been superior to humans in ambiguous situations; however, the nascent computerized braking technology was disabled the day of the crash, and the machine's apparent 4.7-second perception–reaction (alarm) time allowed the car to travel 250 feet (76 m). Video released by the police on March 21 showed the safety driver was not watching the road moments before the vehicle struck Herzberg. === Environment === In widely disseminated remarks that would shape the narrative about the crash, which were later seen as prejudicial and subsequently contradicted by her own department, Tempe Police Chief Sylvia Moir was quoted stating that the collision was "unavoidable" based on the initial police investigation, which included a review of the video captured by an onboard camera. Moir faulted Herzberg for crossing the road in an unsafe manner: "It is dangerous to cross roadways in the evening hour when well-illuminated, managed crosswalks are available." According to Uber, safety drivers were trained to keep their hands very close to the wheel all the time while driving the vehicle so they were ready to quickly take control if necessary. The driver said it was like a flash, the person walked out in front of them. His [sic] first alert to the collision was the sound of the collision. [...] it's very clear it would have been difficult to avoid this collision in any kind of mode (autonomous or human-driven) based on how she came from the shadows right into the roadway. Tempe police released video on March 21, 2018, showing footage recorded by two onboard cameras: one forward-looking, and one capturing the safety driver's actions. The forward-facing video shows that the self-driving car was traveling in the far right lane when it struck Herzberg. The driver-facing video shows the safety driver was looking down prior to the collision. The Uber operator is responsible for intervening and taking manual control when necessary as well as for monitoring diagnostic messages, which are displayed on a screen in the center console. In an interview conducted after the crash with NTSB, the driver stated she was monitoring the center stack at the time of the collision. After the Uber video was released, journalist Carolyn Said noted the police explanation of Herzberg's path meant she had already crossed two lanes of traffic before she was struck by the autonomous vehicle. The Marquee Theatre and Tempe Town Lake are west of Mill Avenue, and pedestrians commonly cross mid-street without detouring north to the crosswalk at Curry. According to reporting by the Phoenix New Times, Mill Avenue contains what appears to be a brick-paved path in the median between the northbound and southbound lanes; however, posted signs prohibit pedestrians from crossing in that location. When the second of the Mill Avenue bridges over the town lake was added in 1994 for northbound traffic, the X-shaped crossover in the median was installed to accommodate the potential closing of one of the two road bridges. The purpose of this brick-paved structure is purely to divert cars from one side to the other if a bridge is closed to traffic, and although it may look like a crosswalk for pedestrians, it is in fact a temporary roadway with vertical curbs and warning signs. === Software issues === Michael Ramsey, a self-driving car expert with Gartner, characterized the video as showing "a complete failure of the system to recognize an obviously seen person who is visible for quite some distance in the frame. Uber has some serious explaining to do about why this person wasn't seen and why the system didn't engage." The NTSB preliminary report, however, noted that the software did order the car to brake 1.3 seconds before the collision. A video shot from the vehicle's dashboard camera showed the safety driver looking down, away from the road. It also appeared that the driver's hands were not hovering above the steering wheel, which is what drivers are instructed to do so they can quickly retake control of the car. Uber had moved from two employees in every car to one. The paired employees had been splitting duties: one ready to take over if the autonomous system failed, and another to keep an eye on what the computers were detecting. The second person was responsible for keeping track of system performance as well as labeling data on a laptop computer. Mr. Kallman, the Uber spokesman, said the second person was in the car for purely data related tasks, not safety. When Uber moved to a single operator, some employees expressed safety concerns to managers, according to the two people familiar with Uber's operations. They were worried that going solo would make it harder to remain alert during hours of monotonous driving. The recorded telemetry showed the system had detected Herzberg six seconds before the crash, and classified her first as an unknown object, then as a
Megami Tensei
Megami Tensei, marketed internationally as Shin Megami Tensei (formerly Revelations), is a Japanese media franchise created by Aya Nishitani, Kouji "Cozy" Okada, Ginichiro Suzuki, and Kazunari Suzuki. Primarily developed and published by Atlus, the franchise consists of multiple subseries and covers multiple role-playing video game genres including tactical role-playing, action role-playing, and massively multiplayer online role-playing. The first two titles in the series were published by Namco (now Bandai Namco Entertainment), but have been almost always published by Atlus in Japan and North America since the release of Shin Megami Tensei. For Europe, Atlus publishes the games through third-party companies. The series was originally based on Digital Devil Story, a science fiction novel series by Aya Nishitani. The series takes its name from the first book's subtitle. Most Megami Tensei titles are stand-alone entries with their own stories and characters. Recurring elements include plot themes, a story shaped by the player's choices, and the ability to fight using and often recruit creatures (demons, Personas) to aid the player in battle. Elements of philosophy, religion, occultism, and science fiction have all been incorporated into the series at different times. While not maintaining as high a profile as series such as Final Fantasy and Dragon Quest, it is highly popular in Japan and maintains a strong cult following in the West, finding critical and commercial success. The series has become well known for its artistic direction, challenging gameplay, and music, but raised controversy over its mature content, dark themes, and use of Christian religious imagery. Additional media include manga adaptations, anime films, and television series. In Japan, some games in the series do not use the "Megami Tensei" title, such as the Persona sub-series. Many of the early games in the series were not localized due to potentially controversial content including religious references, and later due to their age. English localizations have used the "Shin Megami Tensei" moniker since the release of Shin Megami Tensei: Nocturne in 2004. == Titles == === Games === The first installment in the franchise, Digital Devil Story: Megami Tensei, was released on September 11, 1987. The following entries have nearly always been unrelated to each other except in carrying over thematic and gameplay elements. The Megami Tensei games, and the later Shin Megami Tensei titles form the core of the series, while other subseries such as Persona, Devil Children, and Devil Summoner are spin-offs marketed as part of the franchise. There are also stand-alone spin-off titles. ==== Main series ==== Two entries were released for the Famicom: Digital Devil Story: Megami Tensei in 1987, and Digital Devil Story: Megami Tensei II in 1990. The two titles are unrelated to each other in terms of story, and each introduced the basic gameplay and story mechanics that would come to define the series. Three entries were released for the Super Famicom: Shin Megami Tensei in 1992, followed byShin Megami Tensei II in 1994, and Shin Megami Tensei If..., released later in the same year. Shin Megami Tensei III: Nocturne was released in 2003 for the PlayStation 2. Its Maniax Edition director's cut was released in Japan and North America in 2004, and in Europe in 2005. The numeral was dropped for its North American release, and its title changed to Shin Megami Tensei: Lucifer's Call in Europe. Shin Megami Tensei IV for the Nintendo 3DS was released in 2013 in Japan and North America, and a year later in Europe as a digital-only release. Another game set in the same universe, Shin Megami Tensei IV: Apocalypse, was released for the 3DS in February 2016 in Japan. Shin Megami Tensei V was released on the Nintendo Switch in 2021. An enhanced version of the game titled Shin Megami Tensei V: Vengeance was released in June 2024 for Microsoft Windows, Nintendo Switch, PlayStation 4, PlayStation 5, Xbox One and Xbox Series X/S. In addition to the main series, there are also numerous spin-offs. Shin Megami Tensei: Nine, was released for the Xbox in 2002. Originally designed as a massively multiplayer online role-playing game (MMORPG), it was later split into a dual single-player and multiplayer package, and the single-player version released first. The online version was delayed and eventually cancelled as the developers could not manage the required online capacities using Xbox Live. Shin Megami Tensei: Imagine, a true MMOROG released for Microsoft Windows, was released in 2007 in Japan, 2008 in North America, and 2009 in Europe. Western service was terminated in 2014 when Marvelous USA, the game's then-handlers, shut down their PC Online game department. Shin Megami Tensei: Strange Journey was released for the Nintendo DS in 2009 in Japan and 2010 in North America. Its Japanese service ended in May 2016. A smartphone game, Shin Megami Tensei: Liberation Dx2, was released in 2018. ==== Persona ==== The Persona series is the largest and most popular spin-off from the Megami Tensei series. The first entry in the series, Megami Ibunroku Persona (originally released overseas as Revelations: Persona), was released in 1996 in Japan and North America. The first Persona 2 title, Innocent Sin, was released in 1999 in Japan. The second game, Eternal Punishment, was released in 2000 in Japan and North America. Persona 3 was released in 2006 in Japan, 2007 in North America, and 2008 in Europe. Its sequel, Persona 4, was released in 2008 in Japan and North America, and in 2009 in Europe. A sixth entry in the series, Persona 5, was released in Japan on September 15, 2016, and was released in North America and Europe on April 4, 2017, to critical acclaim. The series also features spin-offs, including Persona Q: Shadow of the Labyrinth and Persona Q2: New Cinema Labyrinth, two fighting games Persona 4 Arena and its sequel Arena Ultimax as well as the crossover fighting game BlazBlue: Cross Tag Battle, tactical role-playing game Persona 5 Tactica, action role-playing game Persona 5 Strikers and rhythm games Persona 4: Dancing All Night, Persona 3: Dancing in Moonlight, and Persona 5: Dancing in Starlight. While Persona 3 and 4 used the Shin Megami Tensei moniker in the West, it was dropped for the Persona 4 Arena duology and Persona 4 Golden as it would have made the titles too long to be practical. ==== Devil Summoner ==== The Devil Summoner subseries began in 1995 with the release of Shin Megami Tensei: Devil Summoner. It was followed by Devil Summoner: Soul Hackers in 1997, then followed by Soul Hackers 2, released in 2022. Two action role-playing prequels set in 1920s Tokyo were also developed, which revolve around demon summoner Raidou Kuzunoha: Raidou Kuzunoha vs. the Soulless Army was released in 2006, and Raidou Kuzunoha vs. King Abaddon was released in 2008. ==== Other spin-offs ==== Aside from Persona and Devil Summoner, there are other spin-off series covering multiple genres. After the release of Shin Megami Tensei II, Atlus began focusing work on building spin-offs and subseries that would form part of the Megami Tensei franchise. Shortly after Nocturne's release, a duology titled Digital Devil Saga (Digital Devil Saga: Avatar Tuner in Japan) was created based around similar systems to Nocturne, and was also intended as a more accessible gaming experience. Two tactical role-playing games have been developed by Atlus for the DS under the Devil Survivor moniker: the original Devil Survivor and Devil Survivor 2. Both have received expanded ports for the 3DS. Other subseries include Last Bible, a series aimed at a younger audience and using a pure fantasy setting; Devil Children, which was inspired by the popular Pokémon series; and Majin Tensei, a series of strategy games. Two notable stand-alone spin-offs are action spin-off Jack Bros. and Tokyo Mirage Sessions ♯FE, a crossover with Intelligent Systems' Fire Emblem series. === Related media === Several titles in the franchise have received anime and manga adaptations. Persona 3 received both a four-part theatrical adaptation (#1 Spring of Birth, #2 Midsummer Knight's Dream, #3 Falling Down, #4 Winter of Rebirth), and a spin-off series titled Persona: Trinity Soul. Persona 4 received two adaptations: Persona 4: The Animation, based on the original game, and Persona 4: The Golden Animation, based on its expanded PlayStation Vita port. A live-action television series based on the original Devil Summoner was broadcast between 1997 and 1998. Devil Survivor 2 also received an anime adaptation of the same name, and the Devil Children series received two anime adaptations. Multiple Shin Megami Tensei and Persona titles have received manga and CD drama adaptations. Action figures and merchandise related to Persona have also been produced. == Common elements == Despite most games in the series taking place in different continuities, they do share certain elements
Fuzzy classification
Fuzzy classification is the process of grouping elements into fuzzy sets whose membership functions are defined by the truth value of a fuzzy propositional function. A fuzzy propositional function is analogous to an expression containing one or more variables, such that when values are assigned to these variables, the expression becomes a fuzzy proposition. Accordingly, fuzzy classification is the process of grouping individuals having the same characteristics into a fuzzy set. A fuzzy classification corresponds to a membership function μ C ~ : P F ~ × U → T ~ {\textstyle \mu _{\tilde {C}}:{\tilde {PF}}\times U\to {\tilde {T}}} that indicates the degree to which an individual i ∈ U {\textstyle i\in U} is a member of the fuzzy class C ~ {\textstyle {\tilde {C}}} , given its fuzzy classification predicate Π ~ C ~ ∈ P F ~ {\textstyle {\tilde {\Pi }}_{\tilde {C}}\in {\tilde {PF}}} . Here, T ~ {\textstyle {\tilde {T}}} is the set of fuzzy truth values, i.e., the unit interval [ 0 , 1 ] {\textstyle [0,1]} . The fuzzy classification predicate Π ~ C ~ ( i ) {\textstyle {\tilde {\Pi }}_{\tilde {C}}(i)} corresponds to the fuzzy restriction " i {\textstyle i} is a member of C ~ {\textstyle {\tilde {C}}} ". == Classification == Intuitively, a class is a set that is defined by a certain property, and all objects having that property are elements of that class. The process of classification evaluates for a given set of objects whether they fulfill the classification property, and consequentially are a member of the corresponding class. However, this intuitive concept has some logical subtleties that need clarification. A class logic is a logical system which supports set construction using logical predicates with the class operator { ⋅ | ⋅ } {\textstyle \{\cdot |\cdot \}} . A class C = { i | Π ( i ) } {\displaystyle C=\{i|\Pi (i)\}} is defined as a set C of individuals i satisfying a classification predicate Π which is a propositional function. The domain of the class operator { .| .} is the set of variables V and the set of propositional functions PF, and the range is the powerset of this universe P(U) that is, the set of possible subsets: { ⋅ | ⋅ } : V × P F → P ( U ) {\displaystyle \{\cdot |\cdot \}:V\times PF\rightarrow P(U)} Here is an explanation of the logical elements that constitute this definition: An individual is a real object of reference. A universe of discourse is the set of all possible individuals considered. A variable V :→ R {\textstyle V:\rightarrow R} is a function which maps into a predefined range R without any given function arguments: a zero-place function. A propositional function is "an expression containing one or more undetermined constituents, such that, when values are assigned to these constituents, the expression becomes a proposition". In contrast, classification is the process of grouping individuals having the same characteristics into a set. A classification corresponds to a membership function μ that indicates whether an individual is a member of a class, given its classification predicate Π. μ : P F × U → T {\displaystyle \mu :PF\times U\rightarrow T} The membership function maps from the set of propositional functions PF and the universe of discourse U into the set of truth values T. The membership μ of individual i in Class C is defined by the truth value τ of the classification predicate Π. μ C ( i ) := τ ( Π ( i ) ) {\displaystyle \mu C(i):=\tau (\Pi (i))} In classical logic the truth values are certain. Therefore a classification is crisp, since the truth values are either exactly true or exactly false.
AstroPay
AstroPay is a global digital wallet that provides users with a way to pay, send, and receive money. The app provides online payments, virtual and physical debit cards, peer-to-peer money transfers, and more. == History == AstroPay was founded in Uruguay in 2009 as a payment processing company. Over time, it expanded its services across Latin America, EMEA, and APAC. A significant milestone occurred in 2016, when AstroPay spun off dLocal, focusing on cross-border payments for emerging markets. dLocal became Uruguay's first unicorn and eventually went public through a successful IPO. In 2020, AstroPay spun off its payment processing services into a new entity, D24, to focus on mobile wallet for cross border. Between 2023 and 2024 the Company brought new leadership to guide its transition towards becoming a fully focused global digital multicurrency wallet where users save, send, and spend globally. This shift introduced enhanced features, including loyalty prepaid cards and multicurrency accounts. == Services == AstroPay offers three main products: AstroPay Wallet, AstroPay check-out, and AstroPay Platform. AstroPay Wallet is a digital wallet for consumers, where they have multicurrency accounts, prepaid card and marketplace. With AstroPay check-out, businesses can tap into AstroPay's wallet user base by accepting AstroPay as a payment method in their check-out options. Lastly, AstroPay Platform enables other businesses to use the AstroPay network to launch their own global wallet. == Brand endorsements, partnerships == AstroPay's marketing strategy has included the development of co-branded products with sports teams and other brand. The company sponsored Burnley Football Club during the 2018–19 Premier League season, renewing the partnership for the 2021–22 Premier League season when it became the club's official payment service partner. In August 2021, AstroPay entered into a partnership with the Wolverhampton Wanderers for the 2021-22 Premier League season, and the following year, became the team's shirt sponsor. Later, in September 2021, AstroPay expanded its partnership with Wolverhampton Wanderers, which included becoming the team's official payment partner and later, in 2023, co-launching a co-branded card. Other partnerships include Newcastle United in 2021 in the English Premier League. AstroPay made arrangements to ensure that branding and logo would be visible on the pitch-side LED advertising during Premier League matches. Furthermore, in June 2022, the company renewed it's partnership with Wolverhampton Wanderers for the 2022-23 Premier League season and launched its Wolves debit card in February 2023. Some other notable partnerships include: Universidad de Chile in 2024, Tottenham Hotspurs in 2023-25, and even a collaboration with Lionel Messi across all of Latin America. == Recent developments == AstroPay has refocused its strategy since 2023, pivoting from payment processing to concentrate on its global digital wallet. This move reflects a broader effort to redefine the company's market positioning by emphasizing global user-friendly financial services, while separating its identity from previous operations managed by dLocal and D24.
Tensor network
Tensor networks or tensor network states are a class of variational wave functions used in the study of many-body quantum systems and fluids. Tensor networks extend one-dimensional matrix product states to higher dimensions while preserving some of their useful mathematical properties. The wave function is encoded as a tensor contraction of a network of individual tensors. The structure of the individual tensors can impose global symmetries on the wave function (such as antisymmetry under exchange of fermions) or restrict the wave function to specific quantum numbers, like total charge, angular momentum, or spin. It is also possible to derive strict bounds on quantities like entanglement and correlation length using the mathematical structure of the tensor network. This has made tensor networks useful in theoretical studies of quantum information in many-body systems. They have also proved useful in variational studies of ground states, excited states, and dynamics of strongly correlated many-body systems. == Diagrammatic notation == In general, a tensor network diagram (Penrose diagram) can be viewed as a graph where nodes (or vertices) represent individual tensors, while edges represent summation over an index. Free indices are depicted as edges (or legs) attached to a single vertex only. Sometimes, there is also additional meaning to a node's shape. For instance, one can use trapezoids for unitary matrices or tensors with similar behaviour. This way, flipped trapezoids would be interpreted as complex conjugates to them. == History == Foundational research on tensor networks began in 1971 with a paper by Roger Penrose. In "Applications of negative dimensional tensors" Penrose developed tensor diagram notation, describing how the diagrammatic language of tensor networks could be used in applications in physics. In 1992, Steven R. White developed the density matrix renormalization group (DMRG) for quantum lattice systems. The DMRG was the first successful tensor network and associated algorithm. In 2002, Guifré Vidal and Reinhard Werner attempted to quantify entanglement, laying the groundwork for quantum resource theories. This was also the first description of the use of tensor networks as mathematical tools for describing quantum systems. In 2004, Frank Verstraete and Ignacio Cirac developed the theory of matrix product states, projected entangled pair states, and variational renormalization group methods for quantum spin systems. In 2006, Vidal developed the multi-scale entanglement renormalization ansatz (MERA). In 2007 he developed entanglement renormalization for quantum lattice systems. In 2010, Ulrich Schollwock developed the density-matrix renormalization group for the simulation of one-dimensional strongly correlated quantum lattice systems. In 2014, Román Orús introduced tensor networks for complex quantum systems and machine learning, as well as tensor network theories of symmetries, fermions, entanglement and holography. == Connection to machine learning == Tensor networks have been adapted for supervised learning, taking advantage of similar mathematical structure in variational studies in quantum mechanics and large-scale machine learning. This crossover has spurred collaboration between researchers in artificial intelligence and quantum information science. In June 2019, Google, the Perimeter Institute for Theoretical Physics, and X (company), released TensorNetwork, an open-source library for efficient tensor calculations. The main interest in tensor networks and their study from the perspective of machine learning is to reduce the number of trainable parameters (in a layer) by approximating a high-order tensor with a network of lower-order ones. Using the so-called tensor train technique (TT), one can reduce an N-order tensor (containing exponentially many trainable parameters) to a chain of N tensors of order 2 or 3, which gives us a polynomial number of parameters.