FuseBase (previously Nimbus Note and Nimbus Platform) is a B2B SaaS platform. It is among the first to support the Model Context Protocol (MCP), an open standard enabling seamless integration of AI agents with external tools, systems, and data sources. == History == The platform was founded in 2014 as Nimbus Note, the platform started as a cross-platform note-taking and information management tool. As it evolved into Nimbus Platform, it added project management and client portal capabilities. In 2023, the company rebranded as FuseBase, pivoting to connect and automate both internal and external collaboration through AI Agents and cutting-edge protocol adoption like MCP. At the same time, FuseBase was named Product of the Year on Product Hunt. == Technical overview == The platform integrates the Model Context Protocol (MCP), an open-source framework created by Anthropic. MCP allows AI models to securely access and interact with external data, tools, and systems. This enables FuseBase AI Agents to gather relevant context, perform actions, and provide more advanced automation.
Deep learning in photoacoustic imaging
Photoacoustic imaging (PA) is based on the photoacoustic effect, in which optical absorption causes a rise in temperature, which causes a subsequent rise in pressure via thermo-elastic expansion. This pressure rise propagates through the tissue and is sensed via ultrasonic transducers. Due to the proportionality between the optical absorption, the rise in temperature, and the rise in pressure, the ultrasound pressure wave signal can be used to quantify the original optical energy deposition within the tissue. Photoacoustic imaging has applications of deep learning in both photoacoustic computed tomography (PACT) and photoacoustic microscopy (PAM). PACT utilizes wide-field optical excitation and an array of unfocused ultrasound transducers. Similar to other computed tomography methods, the sample is imaged at multiple view angles, which are then used to perform an inverse reconstruction algorithm based on the detection geometry (typically through universal backprojection, modified delay-and-sum, or time reversal ) to elicit the initial pressure distribution within the tissue. PAM on the other hand uses focused ultrasound detection combined with weakly focused optical excitation (acoustic resolution PAM or AR-PAM) or tightly focused optical excitation (optical resolution PAM or OR-PAM). PAM typically captures images point-by-point via a mechanical raster scanning pattern. At each scanned point, the acoustic time-of-flight provides axial resolution while the acoustic focusing yields lateral resolution. == Applications of deep learning in PACT == The first application of deep learning in PACT was by Reiter et al. in which a deep neural network was trained to learn spatial impulse responses and locate photoacoustic point sources. The resulting mean axial and lateral point location errors on 2,412 of their randomly selected test images were 0.28 mm and 0.37 mm respectively. After this initial implementation, the applications of deep learning in PACT have branched out primarily into removing artifacts from acoustic reflections, sparse sampling, limited-view, and limited-bandwidth. There has also been some recent work in PACT toward using deep learning for wavefront localization. There have been networks based on fusion of information from two different reconstructions to improve the reconstruction using deep learning fusion based networks. === Using deep learning to locate photoacoustic point sources === Traditional photoacoustic beamforming techniques modeled photoacoustic wave propagation by using detector array geometry and the time-of-flight to account for differences in the PA signal arrival time. However, this technique failed to account for reverberant acoustic signals caused by acoustic reflection, resulting in acoustic reflection artifacts that corrupt the true photoacoustic point source location information. In Reiter et al., a convolutional neural network (similar to a simple VGG-16 style architecture) was used that took pre-beamformed photoacoustic data as input and outputted a classification result specifying the 2-D point source location. ==== Deep learning for PA wavefront localization ==== Johnstonbaugh et al. was able to localize the source of photoacoustic wavefronts with a deep neural network. The network used was an encoder-decoder style convolutional neural network. The encoder-decoder network was made of residual convolution, upsampling, and high field-of-view convolution modules. A Nyquist convolution layer and differentiable spatial-to-numerical transform layer were also used within the architecture. Simulated PA wavefronts served as the input for training the model. To create the wavefronts, the forward simulation of light propagation was done with the NIRFast toolbox and the light-diffusion approximation, while the forward simulation of sound propagation was done with the K-Wave toolbox. The simulated wavefronts were subjected to different scattering mediums and Gaussian noise. The output for the network was an artifact free heat map of the targets axial and lateral position. The network had a mean error rate of less than 30 microns when localizing target below 40 mm and had a mean error rate of 1.06 mm for localizing targets between 40 mm and 60 mm. With a slight modification to the network, the model was able to accommodate multi target localization. A validation experiment was performed in which pencil lead was submerged into an intralipid solution at a depth of 32 mm. The network was able to localize the lead's position when the solution had a reduced scattering coefficient of 0, 5, 10, and 15 cm−1. The results of the network show improvements over standard delay-and-sum or frequency-domain beamforming algorithms and Johnstonbaugh proposes that this technology could be used for optical wavefront shaping, circulating melanoma cell detection, and real-time vascular surgeries. === Removing acoustic reflection artifacts (in the presence of multiple sources and channel noise) === Building on the work of Reiter et al., Allman et al. utilized a full VGG-16 architecture to locate point sources and remove reflection artifacts within raw photoacoustic channel data (in the presence of multiple sources and channel noise). This utilization of deep learning trained on simulated data produced in the MATLAB k-wave library, and then later reaffirmed their results on experimental data. === Ill-posed PACT reconstruction === In PACT, tomographic reconstruction is performed, in which the projections from multiple solid angles are combined to form an image. When reconstruction methods like filtered backprojection or time reversal, are ill-posed inverse problems due to sampling under the Nyquist-Shannon's sampling requirement or with limited-bandwidth/view, the resulting reconstruction contains image artifacts. Traditionally these artifacts were removed with slow iterative methods like total variation minimization, but the advent of deep learning approaches has opened a new avenue that utilizes a priori knowledge from network training to remove artifacts. In the deep learning methods that seek to remove these sparse sampling, limited-bandwidth, and limited-view artifacts, the typical workflow involves first performing the ill-posed reconstruction technique to transform the pre-beamformed data into a 2-D representation of the initial pressure distribution that contains artifacts. Then, a convolutional neural network (CNN) is trained to remove the artifacts, in order to produce an artifact-free representation of the ground truth initial pressure distribution. ==== Using deep learning to remove sparse sampling artifacts ==== When the density of uniform tomographic view angles is under what is prescribed by the Nyquist-Shannon's sampling theorem, it is said that the imaging system is performing sparse sampling. Sparse sampling typically occurs as a way of keeping production costs low and improving image acquisition speed. The typical network architectures used to remove these sparse sampling artifacts are U-net and Fully Dense (FD) U-net. Both of these architectures contain a compression and decompression phase. The compression phase learns to compress the image to a latent representation that lacks the imaging artifacts and other details. The decompression phase then combines with information passed by the residual connections in order to add back image details without adding in the details associated with the artifacts. FD U-net modifies the original U-net architecture by including dense blocks that allow layers to utilize information learned by previous layers within the dense block. Another technique was proposed using a simple CNN based architecture for removal of artifacts and improving the k-wave image reconstruction. ==== Removing limited-view artifacts with deep learning ==== When a region of partial solid angles are not captured, generally due to geometric limitations, the image acquisition is said to have limited-view. As illustrated by the experiments of Davoudi et al., limited-view corruptions can be directly observed as missing information in the frequency domain of the reconstructed image. Limited-view, similar to sparse sampling, makes the initial reconstruction algorithm ill-posed. Prior to deep learning, the limited-view problem was addressed with complex hardware such as acoustic deflectors and full ring-shaped transducer arrays, as well as solutions like compressed sensing, weighted factor, and iterative filtered backprojection. The result of this ill-posed reconstruction is imaging artifacts that can be removed by CNNs. The deep learning algorithms used to remove limited-view artifacts include U-net and FD U-net, as well as generative adversarial networks (GANs) and volumetric versions of U-net. One GAN implementation of note improved upon U-net by using U-net as a generator and VGG as a discriminator, with the Wasserstein metric and gradient penalty to stabilize training (WGAN-GP). ==== Pixel-wise interpolation
Shepp–Logan phantom
The Shepp–Logan phantom is a standard test image created by Larry Shepp and Benjamin F. Logan for their 1974 paper "The Fourier Reconstruction of a Head Section". It serves as the model of a human head in the development and testing of image reconstruction algorithms. == Definition == The function describing the phantom is defined as the sum of 10 ellipses inside a 2×2 square:
Layers (digital image editing)
Layers are used in digital image editing to separate different elements of an image. A layer can be compared to a transparency on which imaging effects or images are applied and placed over or under an image. Today they are an integral feature of image editors. In the early days of computing, memory was at a premium and the idea of using multi-layered images was considered infeasible in personal computer applications as the tradeoffs were image size and color depth. As the price of memory fell it became feasible to apply the concept of layering to raster images. The first software known to apply the concept of layers was LALF, which was released in 1989 for the NEC PC-9801. LALF's terminology for layers is "cells", after the concept of drawing animation frames over-top of a stencil. Layers were introduced in Western markets by Fauve Matisse (later Macromedia xRes), and then available in Adobe Photoshop 3.0, in 1994, which lead to widespread adoption. In vector image editors that support animation, layers are used to further enable manipulation along a common timeline for the animation; in SVG images, the equivalent to layers are "groups". == Layer types == There are different kinds of layers, and not all of them exist in all programs. They represent a part of a picture, either as pixels or as modification instructions. They are stacked on top of each other, and depending on the order, determine the appearance of the final picture. In graphics software, layers are the different levels at which one can place an object or image file. In the program, layers can be stacked, merged, or defined when creating a digital image. Layers can be partially obscured allowing portions of images within a layer to be hidden or shown in a translucent manner within another image. Layers can also be used to combine two or more images into a single digital image. For the purpose of editing, working with layers allows for applying changes to just one specific layer. == Layer (basic) == The standard layer available to most programs consists of a rectangular, semitransparent picture which may be superimposed over other layers. Some programs require that layers cover the same area as the final canvas, but others offer layers of multiple sizes. Each layer may bear individual settings, such as opacity, blending modes, dynamic filters, and potentially hundreds of other properties. == Layer mask == A layer mask is linked to a layer and hides part of the layer from the picture. What is painted black on the layer mask will not be visible in the final picture. What is grey will be more or less transparent depending on the shade of grey. As the layer mask can be both edited and moved around independently of both the background layer and the layer it applies to, it gives the user the ability to test a lot of different combinations of overlay. == Adjustment layer == An adjustment layer typically applies a common effect like brightness or saturation to other layers. However, as the effect is stored in a separate layer, it is easy to try it out and switch between different alternatives, without changing the original layer. In addition, an adjustment layer can easily be edited, just like a layer mask, so an effect can be applied to just part of the image.
Oculus Medium
Oculus Medium is a digital sculpting software that works with virtual reality headsets and 6DoF motion controllers. It is used to create and paint digital sculptures. Medium works only on Oculus Rift. It was released on December 5, 2016, following with a major update in 2018 introducing new features and a revamped UI. On December 9, 2019, Oculus Medium was acquired by Adobe and re-named to "Medium by Adobe".
AIXI
AIXI is a theoretical mathematical formalism for artificial general intelligence. It combines Solomonoff induction with sequential decision theory. AIXI was first proposed by Marcus Hutter in 2000 and several results regarding AIXI are proved in Hutter's 2005 book Universal Artificial Intelligence. AIXI is a reinforcement learning (RL) agent. It maximizes the expected total rewards received from the environment. Intuitively, it simultaneously considers every computable hypothesis (or environment). In each time step, it looks at every possible program and evaluates how many rewards that program generates depending on the next action taken. The promised rewards are then weighted by the subjective belief that this program constitutes the true environment. This belief is computed from the length of the program: longer programs are considered less likely, in line with Occam's razor. AIXI then selects the action that has the highest expected total reward in the weighted sum of all these programs. == Etymology == According to Hutter, the word "AIXI" can have several interpretations. AIXI can stand for AI based on Solomonoff's distribution, denoted by ξ {\displaystyle \xi } (which is the Greek letter xi), or e.g. it can stand for AI "crossed" (X) with induction (I). There are other interpretations. == Definition == AIXI is a reinforcement learning agent that interacts with some stochastic and unknown but computable environment μ {\displaystyle \mu } . The interaction proceeds in time steps, from t = 1 {\displaystyle t=1} to t = m {\displaystyle t=m} , where m ∈ N {\displaystyle m\in \mathbb {N} } is the lifespan of the AIXI agent. At time step t, the agent chooses an action a t ∈ A {\displaystyle a_{t}\in {\mathcal {A}}} (e.g. a limb movement) and executes it in the environment, and the environment responds with a "percept" e t ∈ E = O × R {\displaystyle e_{t}\in {\mathcal {E}}={\mathcal {O}}\times \mathbb {R} } , which consists of an "observation" o t ∈ O {\displaystyle o_{t}\in {\mathcal {O}}} (e.g., a camera image) and a reward r t ∈ R {\displaystyle r_{t}\in \mathbb {R} } , distributed according to the conditional probability μ ( o t r t | a 1 o 1 r 1 . . . a t − 1 o t − 1 r t − 1 a t ) {\displaystyle \mu (o_{t}r_{t}|a_{1}o_{1}r_{1}...a_{t-1}o_{t-1}r_{t-1}a_{t})} , where a 1 o 1 r 1 . . . a t − 1 o t − 1 r t − 1 a t {\displaystyle a_{1}o_{1}r_{1}...a_{t-1}o_{t-1}r_{t-1}a_{t}} is the "history" of actions, observations and rewards. The environment μ {\displaystyle \mu } is thus mathematically represented as a probability distribution over "percepts" (observations and rewards) which depend on the full history, so there is no Markov assumption (as opposed to other RL algorithms). Note again that this probability distribution is unknown to the AIXI agent. Furthermore, note again that μ {\displaystyle \mu } is computable, that is, the observations and rewards received by the agent from the environment μ {\displaystyle \mu } can be computed by some program (which runs on a Turing machine), given the past actions of the AIXI agent. The only goal of the AIXI agent is to maximize ∑ t = 1 m r t {\displaystyle \sum _{t=1}^{m}r_{t}} , that is, the sum of rewards from time step 1 to m. The AIXI agent is associated with a stochastic policy π : ( A × E ) ∗ → A {\displaystyle \pi :({\mathcal {A}}\times {\mathcal {E}})^{}\rightarrow {\mathcal {A}}} , which is the function it uses to choose actions at every time step, where A {\displaystyle {\mathcal {A}}} is the space of all possible actions that AIXI can take and E {\displaystyle {\mathcal {E}}} is the space of all possible "percepts" that can be produced by the environment. The environment (or probability distribution) μ {\displaystyle \mu } can also be thought of as a stochastic policy (which is a function): μ : ( A × E ) ∗ × A → E {\displaystyle \mu :({\mathcal {A}}\times {\mathcal {E}})^{}\times {\mathcal {A}}\rightarrow {\mathcal {E}}} , where the ∗ {\displaystyle } is the Kleene star operation. In general, at time step t {\displaystyle t} (which ranges from 1 to m), AIXI, having previously executed actions a 1 … a t − 1 {\displaystyle a_{1}\dots a_{t-1}} (which is often abbreviated in the literature as a < t {\displaystyle a_{ In digital imaging, a pixel (abbreviated px), pel, or picture element is the smallest addressable physical element of a raster image or the smallest controllable element of a display device or dot matrix printer. Pixels are arranged in a regular, two-dimensional grid, and each pixel serves as a sample of an original image, with a greater number of samples typically providing more accurate representations. Each pixel possesses a specific intensity or color, often composed of three or four component intensities, such as red, green, and blue (RGB), or cyan, magenta, yellow, and black (CMYK). The intensity of each pixel is variable, and in color imaging systems, these components are combined to produce a wide spectrum of colors. The concept of a picture element has existed since the early days of television, appearing as "Bildpunkt" in a 1888 German patent, and the term "pixel" has been used in various U.S. patents since 1911. In most digital display devices, pixels are the smallest element that can be manipulated through software. Each pixel is a sample of an original image; more samples typically provide more accurate representations of the original. The intensity of each pixel is variable. In color imaging systems, a color is typically represented by three or four component intensities such as red, green, and blue, or cyan, magenta, yellow, and black. In some contexts (such as descriptions of camera sensors), pixel refers to a single scalar element of a multi-component representation (called a photosite in the camera sensor context, although sensel 'sensor element' is sometimes used), while in yet other contexts (like MRI) it may refer to a set of component intensities for a spatial position. Software on early consumer computers was necessarily rendered at a low resolution, with large pixels visible to the naked eye; graphics made under these limitations may be called pixel art, especially in reference to video games. Modern computers and displays, however, can easily render orders of magnitude more pixels than was previously possible, necessitating the use of large measurements like the megapixel (one million pixels). == Etymology == The word pixel is a combination of pix (from "pictures", shortened to "pics") and el (for "element"); similar formations with 'el' include the words voxel 'volume pixel', and texel 'texture pixel'. The word pix appeared in Variety magazine headlines in 1932, as an abbreviation for the word pictures, in reference to movies. By 1938, "pix" was being used in reference to still pictures by photojournalists. The word "pixel" was first published in 1965 by Frederic C. Billingsley of JPL, to describe the picture elements of scanned images from space probes to the Moon and Mars. Billingsley had learned the word from Keith E. McFarland, at the Link Division of General Precision in Palo Alto, who in turn said he did not know where it originated. McFarland said simply it was "in use at the time" (c. 1963). The concept of a "picture element" dates to the earliest days of television, for example as "Bildpunkt" (the German word for pixel, literally 'picture point') in the 1888 German patent of Paul Nipkow. According to various etymologies, the earliest publication of the term picture element itself was in Wireless World magazine in 1927, though it had been used earlier in various U.S. patents filed as early as 1911. Some authors explain pixel as picture cell, as early as 1972. In graphics and in image and video processing, pel is often used instead of pixel. For example, IBM used it in their Technical Reference for the original PC. Pixilation, spelled with a second i, is an unrelated filmmaking technique that dates to the beginnings of cinema, in which live actors are posed frame by frame and photographed to create stop-motion animation. An archaic British word meaning "possession by spirits (pixies)", the term has been used to describe the animation process since the early 1950s; various animators, including Norman McLaren and Grant Munro, are credited with popularizing it. == Technical == A pixel is generally thought of as the smallest single component of a digital image. However, the definition is highly context-sensitive. For example, there can be "printed pixels" in a page, or pixels carried by electronic signals, or represented by digital values, or pixels on a display device, or pixels in a digital camera (photosensor elements). This list is not exhaustive and, depending on context, synonyms include pel, sample, byte, bit, dot, and spot. Pixels can be used as a unit of measure such as: 2400 pixels per inch, 640 pixels per line, or spaced 10 pixels apart. The measures "dots per inch" (dpi) and "pixels per inch" (ppi) are sometimes used interchangeably, but have distinct meanings, especially for printer devices, where dpi is a measure of the printer's density of dot (e.g. ink droplet) placement. For example, a high-quality photographic image may be printed with 600 ppi on a 1200 dpi inkjet printer. Even higher dpi numbers, such as the 4800 dpi quoted by printer manufacturers since 2002, do not mean much in terms of achievable resolution. The more pixels used to represent an image, the closer the result can resemble the original. The number of pixels in an image is sometimes called the resolution, though resolution has a more specific definition. Pixel counts can be expressed as a single number, as in a "three-megapixel" digital camera, which has a nominal three million pixels, or as a pair of numbers, as in a "640 by 480 display", which has 640 pixels from side to side and 480 from top to bottom (as in a VGA display) and therefore has a total number of 640 × 480 = 307,200 pixels, or 0.3 megapixels. The pixels, or color samples, that form a digitized image (such as a JPEG file used on a web page) may or may not be in one-to-one correspondence with screen pixels, depending on how a computer displays an image. In computing, an image composed of pixels is known as a bitmapped image or a raster image. The word raster originates from television scanning patterns, and has been widely used to describe similar halftone printing and storage techniques. === Sampling patterns === For convenience, pixels are normally arranged in a regular two-dimensional grid. By using this arrangement, many common operations can be implemented by uniformly applying the same operation to each pixel independently. Other arrangements of pixels are possible, with some sampling patterns even changing the shape (or kernel) of each pixel across the image. For this reason, care must be taken when acquiring an image on one device and displaying it on another, or when converting image data from one pixel format to another. For example: Liquid-crystal displays (LCDs) typically use a staggered grid, where the red, green, and blue components are sampled at slightly different locations. Subpixel rendering is a technology which takes advantage of these differences to improve the rendering of text on LCD screens. The vast majority of color digital cameras use a Bayer filter, resulting in a regular grid of pixels where the color of each pixel depends on its position on the grid. A clipmap uses a hierarchical sampling pattern, where the size of the support of each pixel depends on its location within the hierarchy. Warped grids are used when the underlying geometry is non-planar, such as images of the earth from space. The use of non-uniform grids is an active research area, attempting to bypass the traditional Nyquist limit. Pixels on computer monitors are normally "square" (that is, have equal horizontal and vertical sampling pitch); pixels in other systems are often "rectangular" (that is, have unequal horizontal and vertical sampling pitch – oblong in shape), as are digital video formats with diverse aspect ratios, such as the anamorphic widescreen formats of the Rec. 601 digital video standard. === Resolution of computer monitors === Computer monitors (and TV sets) generally have a fixed native resolution. What it is depends on the monitor, and size. See below for historical exceptions. Computers can use pixels to display an image, often an abstract image that represents a GUI. The resolution of this image is called the display resolution and is determined by the video card of the computer. Flat-panel monitors (and TV sets), e.g. OLED or LCD monitors, or E-ink, also use pixels to display an image, and have a native resolution, and it should (ideally) be matched to the video card resolution. Each pixel is made up of triads, with the number of these triads determining the native resolution. On older, historically available, CRT monitors the resolution was possibly adjustable (still lower than what modern monitor achieve), while on some such monitors (or TV sets) the beam sweep rate was fixed, resulting in a fixed native resolution. Most CRT monitors do not have a fixed beam sweep rate, meaning they do not have a native resolution at all – instead theyPixel