Reflection in computer graphics is used to render reflective objects like mirrors and shiny surfaces. Accurate reflections are commonly computed using ray tracing whereas approximate reflections can usually be computed faster by using simpler methods such as environment mapping. Reflections on shiny surfaces like wood or tile can add to the photorealistic effects of a 3D rendering. == Approaches to reflection rendering == For rendering environment reflections there exist many techniques that differ in precision, computational and implementation complexity. Combination of these techniques are also possible. Image order rendering algorithms based on tracing rays of light, such as ray tracing or path tracing, typically compute accurate reflections on general surfaces, including multiple reflections and self reflections. However these algorithms are generally still too computationally expensive for real time rendering (even though specialized HW exists, such as Nvidia RTX) and require a different rendering approach from typically used rasterization. Reflections on planar surfaces, such as planar mirrors or water surfaces, can be computed simply and accurately in real time with two pass rendering — one for the viewer, one for the view in the mirror, usually with the help of stencil buffer. Some older video games used a trick to achieve this effect with one pass rendering by putting the whole mirrored scene behind a transparent plane representing the mirror. Reflections on non-planar (curved) surfaces are more challenging for real time rendering. Main approaches that are used include: Environment mapping (e.g. cube mapping): a technique that has been widely used e.g. in video games, offering reflection approximation that's mostly sufficient to the eye, but lacking self-reflections and requiring pre-rendering of the environment map. The precision can be increased by using a spatial array of environment maps instead of just one. It is also possible to generate cube map reflections in real time, at the cost of memory and computational requirements. Screen space reflections (SSR): a more expensive technique that traces rays come from pixel data.This requires the data of surface normal and either depth buffer (local space) or position buffer (world space).The disadvantage is that objects not captured in the rendered frame cannot appear in the reflections, which results in unresolved and or false intersections causing artefacts such as reflection vanishment and virtual image. SSR was originally introduced as Real Time Local Reflections in CryENGINE 3. == Types of reflection == Polished - A polished reflection is an undisturbed reflection, like a mirror or chrome surface. Blurry - A blurry reflection means that tiny random bumps, or microfacets, on the surface of the material causes the reflection to be blurry. Metallic - A reflection is metallic if the highlights and reflections retain the color of the reflective object. Glossy - This term can be misused: sometimes, it is a setting which is the opposite of blurry (e.g. when "glossiness" has a low value, the reflection is blurry). Sometimes the term is used as a synonym for "blurred reflection". Glossy used in this context means that the reflection is actually blurred. === Polished or mirror reflection === Mirrors are usually almost 100% reflective. === Metallic reflection === Normal (nonmetallic) objects reflect light and colors in the original color of the object being reflected. Metallic objects reflect lights and colors altered by the color of the metallic object itself. === Blurry reflection === Many materials are imperfect reflectors, where the reflections are blurred to various degrees due to surface roughness that scatters the rays of the reflections. === Glossy reflection === Fully glossy reflection, shows highlights from light sources, but does not show a clear reflection from objects. == Examples of reflections == === Wet floor reflections === The wet floor effect is a graphic effects technique popular in conjunction with Web 2.0 style pages, particularly in logos. The effect can be done manually or created with an auxiliary tool which can be installed to create the effect automatically. Unlike a standard computer reflection (and the Java water effect popular in first-generation web graphics), the wet floor effect involves a gradient and often a slant in the reflection, so that the mirrored image appears to be hovering over or resting on a wet floor.
Shepp–Logan phantom
The Shepp–Logan phantom is a standard test image created by Larry Shepp and Benjamin F. Logan for their 1974 paper "The Fourier Reconstruction of a Head Section". It serves as the model of a human head in the development and testing of image reconstruction algorithms. == Definition == The function describing the phantom is defined as the sum of 10 ellipses inside a 2×2 square:
Learning automaton
A learning automaton is one type of machine learning algorithm studied since 1970s. Learning automata select their current action based on past experiences from the environment. It will fall into the range of reinforcement learning if the environment is stochastic and a Markov decision process (MDP) is used. == History == Research in learning automata can be traced back to the work of Michael Lvovitch Tsetlin in the early 1960s in the Soviet Union. Together with some colleagues, he published a collection of papers on how to use matrices to describe automata functions. Additionally, Tsetlin worked on reasonable and collective automata behaviour, and on automata games. Learning automata were also investigated by researches in the United States in the 1960s. However, the term learning automaton was not used until Narendra and Thathachar introduced it in a survey paper in 1974. == Definition == A learning automaton is an adaptive decision-making unit situated in a random environment that learns the optimal action through repeated interactions with its environment. The actions are chosen according to a specific probability distribution which is updated based on the environment response the automaton obtains by performing a particular action. With respect to the field of reinforcement learning, learning automata are characterized as policy iterators. In contrast to other reinforcement learners, policy iterators directly manipulate the policy π. Another example for policy iterators are evolutionary algorithms. Formally, Narendra and Thathachar define a stochastic automaton to consist of: a set X of possible inputs, a set Φ = { Φ1, ..., Φs } of possible internal states, a set α = { α1, ..., αr } of possible outputs, or actions, with r ≤ s, an initial state probability vector p(0) = ≪ p1(0), ..., ps(0) ≫, a computable function A which after each time step t generates p(t+1) from p(t), the current input, and the current state, and a function G: Φ → α which generates the output at each time step. In their paper, they investigate only stochastic automata with r = s and G being bijective, allowing them to confuse actions and states. The states of such an automaton correspond to the states of a "discrete-state discrete-parameter Markov process". At each time step t=0,1,2,3,..., the automaton reads an input from its environment, updates p(t) to p(t+1) by A, randomly chooses a successor state according to the probabilities p(t+1) and outputs the corresponding action. The automaton's environment, in turn, reads the action and sends the next input to the automaton. Frequently, the input set X = { 0,1 } is used, with 0 and 1 corresponding to a nonpenalty and a penalty response of the environment, respectively; in this case, the automaton should learn to minimize the number of penalty responses, and the feedback loop of automaton and environment is called a "P-model". More generally, a "Q-model" allows an arbitrary finite input set X, and an "S-model" uses the interval [0,1] of real numbers as X. A visualised demo/ Art Work of a single Learning Automaton had been developed by μSystems (microSystems) Research Group at Newcastle University. == Finite action-set learning automata == Finite action-set learning automata (FALA) are a class of learning automata for which the number of possible actions is finite or, in more mathematical terms, for which the size of the action-set is finite.
Quantification (machine learning)
In machine learning, quantification (variously called learning to quantify, or supervised prevalence estimation, or class prior estimation) is the task of using supervised learning in order to train models (quantifiers) that estimate the relative frequencies (also known as prevalence values) of the classes of interest in a sample of unlabelled data items. For instance, in a sample of 100,000 unlabelled tweets known to express opinions about a certain political candidate, a quantifier may be used to estimate the percentage of these tweets which belong to class `Positive' (i.e., which manifest a positive stance towards this candidate), and to do the same for classes `Neutral' and `Negative'. Quantification may also be viewed as the task of training predictors that estimate a (discrete) probability distribution, i.e., that generate a predicted distribution that approximates the unknown true distribution of the items across the classes of interest. Quantification is different from classification, since the goal of classification is to predict the class labels of individual data items, while the goal of quantification it to predict the class prevalence values of sets of data items. Quantification is also different from regression, since in regression the training data items have real-valued labels, while in quantification the training data items have class labels. It has been shown in multiple research works that performing quantification by classifying all unlabelled instances and then counting the instances that have been attributed to each class (the 'classify and count' method) usually leads to suboptimal quantification accuracy. This suboptimality may be seen as a direct consequence of 'Vapnik's principle', which states: If you possess a restricted amount of information for solving some problem, try to solve the problem directly and never solve a more general problem as an intermediate step. It is possible that the available information is sufficient for a direct solution but is insufficient for solving a more general intermediate problem. In our case, the problem to be solved directly is quantification, while the more general intermediate problem is classification. As a result of the suboptimality of the 'classify and count' method, quantification has evolved as a task in its own right, different (in goals, methods, techniques, and evaluation measures) from classification. == Quantification tasks == === Quantification tasks according to the set of classes === The main variants of quantification, according to the characteristics of the set of classes used, are: Binary quantification, corresponding to the case in which there are only n = 2 {\displaystyle n=2} classes and each data item belongs to exactly one of them; Single-label multiclass quantification, corresponding to the case in which there are n > 2 {\displaystyle n>2} classes and each data item belongs to exactly one of them; Multi-label multiclass quantification, corresponding to the case in which there are n ≥ 2 {\displaystyle n\geq 2} classes and each data item can belong to zero, one, or several classes at the same time; Ordinal quantification, corresponding to the single-label multiclass case in which a total order is defined on the set of classes. Regression quantification, a task which stands to 'standard' quantification as regression stands to classification. Strictly speaking, this task is not a quantification task as defined above (since the individual items do not have class labels but are labelled by real values), but has enough commonalities with other quantification tasks to be considered one of them. Most known quantification methods address the binary case or the single-label multiclass case, and only few of them address the multi-label, ordinal, and regression cases. Binary-only methods include the Mixture Model (MM) method, the HDy method, SVM(KLD), and SVM(Q). Methods that can deal with both the binary case and the single-label multiclass case include probabilistic classify and count (PCC), adjusted classify and count (ACC), probabilistic adjusted classify and count (PACC), the Saerens-Latinne-Decaestecker EM-based method (SLD), and KDEy. Methods for multi-label quantification include regression-based quantification (RQ) and label powerset-based quantification (LPQ). Methods for the ordinal case include ordinal versions of the above-mentioned ACC, PACC, and SLD methods, and ordinal versions of the above-mentioned HDy method. Methods for the regression case include Regress and splice and Adjusted regress and sum. === Quantification tasks according to the type of data === Several subtasks of quantification may be identified according to the type of data involved. Example such tasks are: Quantification of networked data. This task consists of performing quantification when the datapoints are members of a relation, i.e., are interlinked. As such, this task is a strict relative of collective classification. Quantification over time. This task consists of performing quantification on sets that become available in a temporal sequence, i.e., as a data stream, and finds application in contexts in which class prevalence values must be monitored over time. == Evaluation measures for quantification == Several evaluation measures can be used for evaluating the error of a quantification method. Since quantification consists of generating a predicted probability distribution that estimates a true probability distribution, these evaluation measures are ones that compare two probability distributions. Most evaluation measures for quantification belong to the class of divergences. Evaluation measures for binary quantification, single-label multiclass quantification, and multi-label quantification, are Absolute Error Squared Error Relative Absolute Error Kullback–Leibler divergence Pearson Divergence Evaluation measures for ordinal quantification are Normalized Match Distance (a particular case of the Earth Mover's Distance) Root Normalized Order-Aware Distance == Applications == Quantification is of special interest in fields such as the social sciences, epidemiology, market research, allocating resources, and ecological modelling, since these fields are inherently concerned with aggregate data. However, quantification is also useful as a building block for solving other downstream tasks, such as improving the accuracy of classifiers on out-of-distribution data, measuring classifier bias and ranker bias, and estimating the accuracy of classifiers on out-of-distribution data. == Resources == LQ 2021: the 1st International Workshop on Learning to Quantify LQ 2022: the 2nd International Workshop on Learning to Quantify LQ 2023: the 3rd International Workshop on Learning to Quantify LQ 2024: the 4th International Workshop on Learning to Quantify LQ 2025: the 5th International Workshop on Learning to Quantify LeQua 2022: the 1st Data Challenge on Learning to Quantify LeQua 2024: the 2nd Data Challenge on Learning to Quantify QuaPy: An open-source Python-based software library for quantification QuantificationLib: A Python library for quantification and prevalence estimation
Compute (machine learning)
In machine learning and deep learning, compute is the amount of computing power or computational resources required to train machine learning models and large language models. More broadly, compute is the computational power or resources necessary for a computer or computer program to function. == Definition == Compute is commonly defined as the amount of computing power or computational resources required to train machine learning and large language models. The term "compute" has also been more broadly applied to cloud computing, referencing processing power, memory, networking, storage, and other resources required for the computation of any program. Compute is measured in petaflop/s-days and is used to document AI training. A petaflop/s-day (pfs-day) consists of performing 1015 neural net operations per second for one day, or a total of about 1020 operations. The compute-time product serves as a mental convenience, similar to kilowatt-hour for energy. An amount of compute is meant to give an idea of the number of actual operations performed. == History == In a 2018 analysis titled "AI and compute", artificial intelligence company OpenAI introduced the concept of compute. OpenAI identified two eras of training AI systems in terms of compute-usage. From 1959 to 2012, compute roughly followed Moore’s law. Between 2012 and 2018, the amount of compute used in the largest AI training runs increased exponentially, growing by more than 300,000 times — roughly doubling every 3.4 months. By comparison, Moore’s Law doubled every two years over the same period. One of the largest models, released in 2020, used 600,000 times more computing power than the 2012 model. After 2020, compute growth began to slow down, with the compute needed for the largest AI models continuing to slow down in 2023. The notion of compute has become increasingly used from the mid-2020s onwards. == Compute growth and AI progress == Larger AI models trained on more data and using more computational resources, tend to perform better. This happens even if the algorithms themselves remain unchanged. As early as 2018, OpenAI noted the exponential increase in compute to be have a key role in AI progress. OpenAI considers three factors drive the advance of AI: algorithmic innovation, data, and the amount of compute available for training. AI models with more compute not only improve in the tasks they were trained on but can develop emergent abilities. Incremental improvements can lead to more abrupt leaps in capabilities. AI provider SpaceXAI said in 2026 that their AI progress is driven by compute and used it a key metric in the AI training of its supercomputer Colossus, the which contains 1 million GPUs. Anthropic has a contract of $1.25 billion per month with SpaceXAI to buy all the compute capacity at Colossus 1 data center. === Criticism and policy === Increasing, promoting or constraining progress in artificial intelligence has often be done via controlling the amount of compute. Policymarkers have enacted policies and provided support to make compute resources more accessible to domestic AI researchers. In a January 2022 report, the Center for Security and Emerging Technology (CSET) suggested to institutions that increasingly powerful and generalizable AI (AGI) will likely require other strategies than maximizing compute. Some AI researchers are also concerned that government might exclusively focus on scaling compute instead of other strategies. The CSET has reported on the various bottlenecks which could explain why deep learning needs for compute have slow down: training is expensive and training extremely large models generates traffic jams across many processors that are difficult to manage. there is a limited supply of AI chips (see AI chip memory shortage). CSET advances that the main resource is human capital, specifically talented researchers — according to a 2023 published survey of more than 400 AI researchers, academic and private sector workers. The survey found that AI researchers are not primarily or exclusively constrained by compute access. However, both academic and industry AI researchers equally report concerns that insufficient compute could prevent them from contributing meaningfully to AI research in the future. High compute users are more concerned about compute access. When asked about which resource provided by the government would be the most useful to them, some AI researchers select compute, other prefer grant funding. For this goal, CSET advised policymakers to ensure that even researchers with smaller budgets could effectively contribute to AI research. Other proposed strategies include using contemporary AI algorithms, managing modern AI infrastructure or focusing on interdisciplinary work between the AI field and other fields of computer science. A 2024 study on compute access found that academic-only AI research teams often have less compute intensive research topics, especially foundation models, compared to industry AI labs. As a consequence, academia is likely to play a smaller role in advancing such techniques. The researchers suggest nationally-sponsored computing infrastructure as well as open science initiatives to boost academic compute access. === Data === A 2022 study found that current large language models are significantly under-trained, a consequence of focusing on scaling language models whilst keeping the amount of training data constant. By training over 400 language models of various parameter and token size, they found that "for compute-optimal training", the model size and the number of training tokens should ideally be scaled equally: for every doubling of model size the number of training tokens should also be doubled.
Human-centered AI
Human-centered AI is the initiative at the intersection of the fields of artificial intelligence (AI) and human-computer interaction (HCI) to develop AI systems in a way that prioritizes human values, needs, and general flourishing. Emphasis is placed on the recognition that artificial intelligence systems are rapidly changing, and will continue to influence, many aspects of the human experience, in areas ranging from scientific inquiry, governance and policy, labor and the economy, and creative expression, with an aim set to adapt current developments and guide future developments on a trajectory which is most beneficial to the human population at large, with the goal of augmenting human intelligence and capacities across these areas, as opposed to replacing them. Particular attention is paid to mitigating negative effects of AI automation on the livelihoods of the labor force, the use of AI in healthcare fields, and imbuing AI systems with societal values. Human-centered AI is linked to related endeavors in AI alignment and AI safety, but while these fields primarily focus on mitigating risks posed by AI that is unaligned to human values and/or uncontrollable AI self-development, human-centered AI places significant focus in exploring how AI systems can augment human capacities and serve as collaborators. == Conceptual history == The importance of the alignment of artificial intelligence development towards human values in some sense predates artificial intelligence itself, as before the modern conception of artificial intelligence as coined at the 1956 Dartmouth Workshop, the conception of robots as constructed, autonomous agents entered the cultural consciousness as early as the 1920s, with Karel Capek's Rossum's Universal Robots. The imagined issues relating to robots' aims and values requiring intentional alignment and direction with those of humans followed soon after, most widely known from science fiction author Isaac Asimov’s Three Laws of Robotics, dating to his 1942 short story “Runaround”. Two of the three eponymous laws are directly concerned with robots’ interaction with and positioned deference towards humans, and have in recent times been reexamined in the face of modern AI. In 1985, after artificial intelligence research had taken off and its effects were more acutely conceptualized, Asimov added a Rule Zero, treating robots' relationship with humanity as a whole, distinct from individual humans. While modern artificial intelligence is largely distinct from robotics, the conceptualization of both robots and AI systems as autonomous agents positions this as a foundation for conceptions of human-centered AI. Aside from robots, artificially intelligent autonomous agents in interaction with humans have been conceived of for at least 75 years. In 1950, Alan Turing published his famous "Imitation Game", often also called the Turing Test, a thought experiment that uses human-machine interaction as an assessor for the intelligence of a system. In recent times, artificial intelligence researchers such as Stanford's Erik Brynjolfsson have conceived of rapid AI development leading to a so-called "Turing Trap". == Augmentation and automation == A major stated aim of human-centered AI is to promote the development of AI in ways that augment human capabilities, rather than replacing them. To this end, organizations and initiatives that take a human-centered approach to AI development focus on frameworks that encourage collaboration between humans and artificial intelligence systems to build towards even greater progress, rather than attempting to automate tasks currently handled by humans. Such avenues include everything from data visualization for big data, allowing human engineers to better understand extremely large datasets, allowing for the design of better machine learning models to handle them, to AI-powered sensors to monitor vitals, allowing for better responsiveness from healthcare providers. Many human-centered AI initiatives often position it as a better alternative to the apparent mainstream in AI development, which is primarily concerned with automation. Driven by the pressures of the market economy, AI development that does replace tasks currently performed by humans with automated processes is incentivized, as it allows for greater profit margins; this often comes at the detriment of the human whose performance is replaced, thus leading to an environment wherein human workers are outcompeted by AI systems across various service-sector and technology-based industries. At the same time, automation and augmentation are not always incompatible; a major aim of human-centered AI is towards the automation of rote tasks that would otherwise hinder a human’s productivity or creativity, freeing them to direct their energy and intelligence towards higher-level tasks, thus achieving augmentation through automation. Empirical research in pharmaceutical sales has shown that a human-centered implementation - where work procedures, training, and incentives are designed around individuals' cognitive needs - improves augmentation performance, while implementation without such adaptation can worsen outcomes relative to a legacy system. == Research == Much of the work done on human-centered AI comes from research institutes, within universities, companies, and as freestanding organizations. The Stanford Institute for Human-Centered AI (abbreviated to HAI) is one such group, engaging academics, industry professionals, and policymakers centered in Stanford University to conduct research and inform policy in various areas in human-centered AI, including on aspects of the intelligence itself, augmentation, and on measuring the impacts of AI systems on sociopolitcal and cultural institutions. Similar groups exist at other universities, including the Chicago Human + AI (CHAI) Lab at the University of Chicago, the HCAI@GU group at the University of Gothenburg, and the Human-Centered AI (HAI) Lab at the University of Oxford. Outside of the academy, companies such as IBM have research initiatives dedicated to advancements in human-centered AI. At Kenyon College, the Integrated Program for Humane Studies (IPHS) launched a human-centered AI program in 2016 integrating artificial intelligence research with humanities and social science inquiry. This approach treats computation and humanistic scholarship as a single unified field of research rather than as separate disciplines requiring collaboration. The program's researchers have published in both AI venues (such as the International Conference on Machine Learning and Frontiers of Computer Science) and humanities journals (such as PMLA and Poetics Today), and the lab was selected in December 2025 by Schmidt Sciences for its Humanities and AI Virtual Institute to apply AI methods to cultural heritage preservation.
Lynda Soderholm
Lynda Soderholm is a physical chemist at the U.S. Department of Energy's (DOE) Argonne National Laboratory with a specialty in f-block elements. She is a senior scientist and the lead of the Actinide, Geochemistry & Separation Sciences Theme within Argonne's Chemical Sciences and Engineering Division. Her specific role is the Separation Science group leader within Heavy Element Chemistry and Separation Science (HESS), directing basic research focused on low-energy methods for isolating lanthanide and actinide elements from complex mixtures. She has made fundamental contributions to understanding f-block chemistry and characterizing f-block elements. Soderholm became a Fellow of the American Association for the Advancement of Science (AAAS) in 2013, and is also an Argonne Distinguished Fellow. == Early life and education == Soderholm was awarded her PhD in 1982 by McMaster University under the direction of Prof John Greedan. Her dissertation focused on characterizing the structural and magnetic properties of a series of ternary f-ion oxides. After graduating, she was awarded a NATO postdoctoral fellow at the Centre national de la recherche scientifique in France from 1982 until 1985. After a short postdoctoral appointment as an Argonne postdoctoral fellow she was promoted to staff scientist the same year. Over several years, she moved up the ranks, becoming a senior chemist in 2001. She was also an adjunct professor at the University of Notre Dame from 2003 until 2007. In 2021, Soderholm was appointed interim Division Director for the Chemical Sciences and Engineering Division. == Career and research == === Uncovering structure of Yttrium-123 Superconductor === Early in her career, Soderholm focused on the characterizing the magnetic and electronic behavior of compounds containing f-ions (lanthanides and actinides) with a focus on high-Tc materials, compounds that are superconducting under usually high temperatures. She was part of the research group that first determined the structure of YBa2Cu3O7. Their discovery formed the foundation for the further developments in the broad field of superconductivity. === Understanding f-ion speciation in solution === Continuing her interest in the f-elements, Soderholm shifted her focus from solid-state materials to nanoparticles and solutions, taking advantage of advances in X-ray structural probes made available by synchrotron facilities. Building on her earlier work using neutron scattering, her team became the first to discover that plutonium exists in solution as tiny, well-defined nanoparticles. This work solved a longstanding problem in understanding transport of plutonium in the environment and resulted in the development of a new, patented approach to separating plutonium during nuclear reprocessing. === Using machine learning to evaluate molecular structures === Soderholm's more recent projects use machine learning to understand the influence of complex molecular structuring in solutions, in connection with low-energy processes for separation of f-block elements from complex mixtures. == Awards and honors == University of Chicago Board of Governors' Distinguished Performance Award, 2009. Fellow of the American Association for the Advancement of Science, 2013. Argonne Distinguished Fellow, 2016 DOE materials sciences research competition for Outstanding Scientific Accomplishments in Solid State Physics, 1987. == Select publications == Beno, M. A.; Soderholm, L.; Capone, D. W., II; Hinks, D. G.; Jorgensen, J. D.; Grace, J. D.; Schuller, I. K.; Segre, C. U.; Zhang, K., Structure of the single-phase high-temperature superconductor yttrium barium copper oxide (YBa2Cu3O7−δ). Appl. Phys. Lett. 1987, 51 (1), 57–9. Soderholm, L.; Zhang, K.; Hinks, D. G.; Beno, M. A.; Jorgensen, J. D.; Segre, C. U.; Schuller, I. K., Incorporation of praseodymium in YBa2Cu3O7−δ: electronic effects on superconductivity. Nature (London) 1987, 328 (6131), 604–5. Antonio, M. R.; Williams, C. W.; Soderholm, L., Berkelium redox speciation. Radiochim. Acta 2002, 90 (12), 851–856. Soderholm, L.; Skanthakumar, S.; Neuefeind, J., Determination of actinide speciation in solution using high-energy X-ray scattering. Anal. Bioanal. Chem. 2005, 383 (1), 48–55. Forbes, T. Z.; Burns, P. C.; Skanthakumar, S.; Soderholm, L., Synthesis, structure, and magnetism of Np2O5. J. Am. Chem. Soc. 2007, 129 (10), 2760–2761. Soderholm, L.; Almond, P. M.; Skanthakumar, S.; Wilson, R. E.; Burns, P. C., The structure of the plutonium oxide nanocluster [Pu38O56Cl54(H2O)8]14-. Angew. Chem., Int. Ed. 2008, 47 (2), 298–302. Jensen, M. P.; Gorman-Lewis, D.; Aryal, B.; Paunesku, T.; Vogt, S.; Rickert, P. G.; Seifert, S.; Lai, B.; Woloschak, G. E.; Soderholm, L., An iron-dependent and transferrin-mediated cellular uptake pathway for plutonium. Nat. Chem. Biol. 2011, 7 (8), 560–565. Wilson, R. E.; Skanthakumar, S.; Soderholm, L., Separation of Plutonium Oxide Nanoparticles and Colloids. Angew. Chem., Int. Ed. 2011, 50 (47), 11234–11237. Knope, K. E.; Soderholm, L., Solution and solid-state structural chemistry of actinide hydrates and their hydrolysis and condensation products. Chem. Rev. 2013, 113 (2), 944–994. Luo, G.; Bu, W.; Mihaylov, M.; Kuzmenko, I.; Schlossman, M. L.; Soderholm, L., X-ray reflectivity reveals a nonmonotonic ion-density profile perpendicular to the surface of ErCl3 aqueous solutions. J. Phys. Chem. C 2013, 117 (37), 19082–19090. Jin, G. B.; Lin, J.; Estes, S. L.; Skanthakumar, S.; Soderholm, L., Influence of countercation hydration enthalpies on the formation of molecular complexes: A thorium-nitrate example. J. Am. Chem. Soc. 2017, 139 (49), 18003–18008. == Patents == Solvent extraction system for plutonium colloids and other oxide nano-particles, (2016).