Mating pool is a concept used in evolutionary algorithms and means a population of parents for the next population. The mating pool is formed by candidate solutions that the selection operators deem to have the highest fitness in the current population. Solutions that are included in the mating pool are referred to as parents. Individual solutions can be repeatedly included in the mating pool, with individuals of higher fitness values having a higher chance of being included multiple times. Crossover operators are then applied to the parents, resulting in recombination of genes recognized as superior. Lastly, random changes in the genes are introduced through mutation operators, increasing the genetic variation in the gene pool. Those two operators improve the chance of creating new, superior solutions. A new generation of solutions is thereby created, the children, who will constitute the next population. Depending on the selection method, the total number of parents in the mating pool can be different to the size of the initial population, resulting in a new population that’s smaller. To continue the algorithm with an equally sized population, random individuals from the old populations can be chosen and added to the new population. At this point, the fitness value of the new solutions is evaluated. If the termination conditions are fulfilled, processes come to an end. Otherwise, they are repeated. The repetition of the steps result in candidate solutions that evolve towards the most optimal solution over time. The genes will become increasingly uniform towards the most optimal gene, a process called convergence. If 95% of the population share the same version of a gene, the gene has converged. When all the individual fitness values have reached the value of the best individual, i.e. all the genes have converged, population convergence is achieved. == Mating pool creation == Several methods can be applied to create a mating pool. All of these processes involve the selective breeding of a particular number of individuals within a population. There are multiple criteria that can be employed to determine which individuals make it into the mating pool and which are left behind. The selection methods can be split into three general types: fitness proportionate selection, ordinal based selection and threshold based selection. === Fitness proportionate selection === In the case of fitness proportionate selection, random individuals are selected to enter the pool. However, the ones with a higher level of fitness are more likely to be picked and therefore have a greater chance of passing on their features to the next generation. One of the techniques used in this type of parental selection is the roulette wheel selection. This approach divides a hypothetical circular wheel into different slots, the size of which is equal to the fitness values of each potential candidate. Afterwards, the wheel is rotated and a fixed point determines which individual gets picked. The greater the fitness value of an individual, the higher the probability of being chosen as a parent by the random spin of the wheel. Alternatively, stochastic universal sampling can be implemented. This selection method is also based on the rotation of a spinning wheel. However, in this case there is more than one fixed point and as a result all of the mating pool members will be selected simultaneously. === Ordinal based selection === The ordinal based selection methods include the tournament and ranking selection. Tournament selection involves the random selection of individuals of a population and the subsequent comparison of their fitness levels. The winners of these “tournaments” are the ones with the highest values and will be put into the mating pool as parents. In ranking selection all the individuals are sorted based on their fitness values. Then, the selection of the parents is made according to the rank of the candidates. Every individual has a chance of being chosen, but higher ranked ones are favored === Threshold based selection === The last type of selection method is referred to as the threshold based method. This includes the truncation selection method, which sorts individuals based on their phenotypic values on a specific trait and later selects the proportion of them that are within a certain threshold as parents.
Kolmogorov–Arnold Networks
Kolmogorov–Arnold Networks (KANs) are a type of artificial neural network architecture inspired by the Kolmogorov–Arnold representation theorem, also known as the superposition theorem. Unlike traditional multilayer perceptrons (MLPs), which rely on fixed activation functions and linear weights, KANs replace each weight with a learnable univariate function, often represented using splines. == History == KANs (Kolmogorov–Arnold Networks) were proposed by Liu et al. (2024) as a generalization of the Kolmogorov–Arnold representation theorem (KART), aiming to outperform MLPs in small-scale AI and scientific tasks. Before KANs, numerous studies explored KART's connections to neural networks or used it as a basis for designing new network architectures. In the 1980s and 1990s, early research applied KART to neural network design. Kůrková et al. (1992), Hecht-Nielsen (1987), and Nees (1994) established theoretical foundations for multilayer networks based on KART. Igelnik et al. (2003) introduced the Kolmogorov Spline Network using cubic splines to model complex functions. Sprecher (1996, 1997) introduced numerical methods for building network layers, while Nakamura et al. (1993) created activation functions with guaranteed approximation accuracy. These works linked KART's theoretical potential with practical neural network implementation. KART has also been used in other computational and theoretical fields. Coppejans (2004) developed nonparametric regression estimators using B-splines, Bryant (2008) applied it to high-dimensional image tasks, Liu (2015) investigated theoretical applications in optimal transport and image encryption, and more recently, Polar and Poluektov (2021) used Urysohn operators for efficient KART construction, while Fakhoury et al. (2022) introduced ExSpliNet, integrating KART with probabilistic trees and multivariate B-splines for improved function approximation. == Architecture == KANs are based on the Kolmogorov–Arnold representation theorem, which was linked to the 13th Hilbert problem. Given x = ( x 1 , x 2 , … , x n ) {\displaystyle x=(x_{1},x_{2},\dots ,x_{n})} consisting of n variables, a multivariate continuous function f ( x ) {\displaystyle f(x)} can be represented as: f ( x ) = f ( x 1 , … , x n ) = ∑ q = 1 2 n + 1 Φ q ( ∑ p = 1 n φ q , p ( x p ) ) {\displaystyle f(x)=f(x_{1},\dots ,x_{n})=\sum _{q=1}^{2n+1}\Phi _{q}\left(\sum _{p=1}^{n}\varphi _{q,p}(x_{p})\right)} (1) This formulation contains two nested summations: an outer and an inner sum. The outer sum ∑ q = 1 2 n + 1 {\displaystyle \sum _{q=1}^{2n+1}} aggregates 2 n + 1 {\displaystyle 2n+1} terms, each involving a function Φ q : R → R {\displaystyle \Phi _{q}:\mathbb {R} \to \mathbb {R} } . The inner sum ∑ p = 1 n {\displaystyle \sum _{p=1}^{n}} computes n terms for each q, where each term φ q , p : [ 0 , 1 ] → R {\displaystyle \varphi _{q,p}:[0,1]\to \mathbb {R} } is a continuous function of the single variable x p {\displaystyle x_{p}} . The inner continuous functions φ q , p {\displaystyle \varphi _{q,p}} are universal, independent of f {\displaystyle f} , while the outer functions Φ q {\displaystyle \Phi _{q}} depend on the specific function f {\displaystyle f} being represented. The representation (1) holds for all multivariate functions f {\displaystyle f} as proved in . If f {\displaystyle f} is continuous, then the outer functions Φ q {\displaystyle \Phi _{q}} are continuous; if f {\displaystyle f} is discontinuous, then the corresponding Φ q {\displaystyle \Phi _{q}} are generally discontinuous, while the inner functions φ q , p {\displaystyle \varphi _{q,p}} remain the same universal functions. Liu et al. proposed the name KAN. A general KAN network consisting of L layers takes x to generate the output as: K A N ( x ) = ( Φ L − 1 ∘ Φ L − 2 ∘ ⋯ ∘ Φ 1 ∘ Φ 0 ) x {\displaystyle \mathrm {KAN} (x)=(\Phi ^{L-1}\circ \Phi ^{L-2}\circ \cdots \circ \Phi ^{1}\circ \Phi ^{0})x} (3) Here, Φ l {\displaystyle \Phi ^{l}} is the function matrix of the l-th KAN layer or a set of pre-activations. Let i denote the neuron of the l-th layer and j the neuron of the (l+1)-th layer. The activation function φ j , i l {\displaystyle \varphi _{j,i}^{l}} connects (l, i) to (l+1, j): φ j , i l , l = 0 , … , L − 1 , i = 1 , … , n l , j = 1 , … , n l + 1 {\displaystyle \varphi _{j,i}^{l},\quad l=0,\dots ,L-1,\;i=1,\dots ,n_{l},\;j=1,\dots ,n_{l+1}} (4) where nl is the number of nodes of the l-th layer. Thus, the function matrix Φ l {\displaystyle \Phi ^{l}} can be represented as an n l + 1 × n l {\displaystyle n_{l+1}\times n_{l}} matrix of activations: x l + 1 = ( φ 1 , 1 l ( ⋅ ) φ 1 , 2 l ( ⋅ ) ⋯ φ 1 , n l l ( ⋅ ) φ 2 , 1 l ( ⋅ ) φ 2 , 2 l ( ⋅ ) ⋯ φ 2 , n l l ( ⋅ ) ⋮ ⋮ ⋱ ⋮ φ n l + 1 , 1 l ( ⋅ ) φ n l + 1 , 2 l ( ⋅ ) ⋯ φ n l + 1 , n l l ( ⋅ ) ) x l {\displaystyle x^{l+1}={\begin{pmatrix}\varphi _{1,1}^{l}(\cdot )&\varphi _{1,2}^{l}(\cdot )&\cdots &\varphi _{1,n_{l}}^{l}(\cdot )\\\varphi _{2,1}^{l}(\cdot )&\varphi _{2,2}^{l}(\cdot )&\cdots &\varphi _{2,n_{l}}^{l}(\cdot )\\\vdots &\vdots &\ddots &\vdots \\\varphi _{n_{l+1},1}^{l}(\cdot )&\varphi _{n_{l+1},2}^{l}(\cdot )&\cdots &\varphi _{n_{l+1},n_{l}}^{l}(\cdot )\end{pmatrix}}x^{l}} == Implementations == To make the KAN layers optimizable, the inner function is formed by the combination of spline and basic functions as the formula: φ ( x ) = w b b ( x ) + w s spline ( x ) {\displaystyle \varphi (x)=w_{b}\,b(x)+w_{s}\,{\text{spline}}(x)} where b ( x ) {\displaystyle b(x)} is the basic function, usually defined as s i l u ( x ) = x / ( 1 + e x ) {\displaystyle silu(x)=x/(1+e^{x})} and w b {\displaystyle w_{b}} is the base weight matrix. Also, w s {\displaystyle w_{s}} is the spline weight matrix and spline ( x ) {\displaystyle {\text{spline}}(x)} is the spline function. The spline function can be a sum of B-splines. spline ( x ) = ∑ i c i B i ( x ) {\displaystyle {\text{spline}}(x)=\sum _{i}c_{i}B_{i}(x)} Many studies suggested to use other polynomial and curve functions instead of B-spline to create new KAN variants. == Functions used == The choice of functional basis strongly influences the performance of KANs. Common function families include: B-splines: Provide locality, smoothness, and interpretability; they are the most widely used in current implementations. RBFs (include Gaussian RBFs): Capture localized features in data and are effective in approximating functions with non-linear or clustered structures. Chebyshev polynomials: Offer efficient approximation with minimized error in the maximum norm, making them useful for stable function representation. Rational function: Useful for approximating functions with singularities or sharp variations, as they can model asymptotic behavior better than polynomials. Fourier series: Capture periodic patterns effectively and are particularly useful in domains such as physics-informed machine learning. Wavelet functions (DoG, Mexican hat, Morlet, and Shannon): Used for feature extraction as they can capture both high-frequency and low-frequency data components. Piecewise linear functions: Provide efficient approximation for multivariate functions in KANs. == Usage == In some modern neural architectures like convolutional neural networks (CNNs), recurrent neural networks (RNNs), and Transformers, KANs are typically used as drop-in substitutes for MLP layers. Despite KANs' general-purpose design, researchers have created and used them for a number of tasks: Scientific machine learning (SciML): Function fitting, partial differential equations (PDEs) and physical/mathematical laws. Continual learning: KANs better preserve previously learned information during incremental updates, avoiding catastrophic forgetting due to the locality of spline adjustments. Graph neural networks: Extensions such as Kolmogorov–Arnold Graph Neural Networks (KA-GNNs) integrate KAN modules into message-passing architectures, showing improvements in molecular property prediction tasks. Sensor data processing: Kolmogorov–Arnold Networks (KANs) have recently been applied to sensor data processing due to their ability to model complex nonlinear relationships with relatively few parameters and improved interpretability compared to conventional multilayer perceptrons. Applications include industrial soft sensors, biomedical signal analysis, remote sensing, and environmental monitoring systems. == Drawbacks == KANs can be computationally intensive and require a large number of parameters due to their use of polynomial functions to capture data.
Scale space
Scale-space theory is a framework for multi-scale signal representation developed by the computer vision, image processing and signal processing communities with complementary motivations from physics and biological vision. It is a formal theory for handling image structures at different scales, by representing an image as a one-parameter family of smoothed images, the scale-space representation, parametrized by the size of the smoothing kernel used for suppressing fine-scale structures. The parameter t {\displaystyle t} in this family is referred to as the scale parameter, with the interpretation that image structures of spatial size smaller than about t {\displaystyle {\sqrt {t}}} have largely been smoothed away in the scale-space level at scale t {\displaystyle t} . The main type of scale space is the linear (Gaussian) scale space, which has wide applicability as well as the attractive property of being possible to derive from a small set of scale-space axioms. The corresponding scale-space framework encompasses a theory for Gaussian derivative operators, which can be used as a basis for expressing a large class of visual operations for computerized systems that process visual information. This framework also allows visual operations to be made scale invariant, which is necessary for dealing with the size variations that may occur in image data, because real-world objects may be of different sizes and in addition the distance between the object and the camera may be unknown and may vary depending on the circumstances. == Definition == The notion of scale space applies to signals of arbitrary numbers of variables. The most common case in the literature applies to two-dimensional images, which is what is presented here. Consider a given image f {\displaystyle f} where f ( x , y ) {\displaystyle f(x,y)} is the greyscale value of the pixel at position ( x , y ) {\displaystyle (x,y)} . The linear (Gaussian) scale-space representation of f {\displaystyle f} is a family of derived signals L ( x , y ; t ) {\displaystyle L(x,y;t)} defined by the convolution of f ( x , y ) {\displaystyle f(x,y)} with the two-dimensional Gaussian kernel g ( x , y ; t ) = 1 2 π t e − ( x 2 + y 2 ) / 2 t {\displaystyle g(x,y;t)={\frac {1}{2\pi t}}e^{-(x^{2}+y^{2})/2t}\,} such that L ( ⋅ , ⋅ ; t ) = g ( ⋅ , ⋅ ; t ) ∗ f ( ⋅ , ⋅ ) , {\displaystyle L(\cdot ,\cdot ;t)\ =g(\cdot ,\cdot ;t)f(\cdot ,\cdot ),} where the semicolon in the argument of L {\displaystyle L} implies that the convolution is performed only over the variables x , y {\displaystyle x,y} , while the scale parameter t {\displaystyle t} after the semicolon just indicates which scale level is being defined. This definition of L {\displaystyle L} works for a continuum of scales t ≥ 0 {\displaystyle t\geq 0} , but typically only a finite discrete set of levels in the scale-space representation would be actually considered. The scale parameter t = σ 2 {\displaystyle t=\sigma ^{2}} is the variance of the Gaussian filter and as a limit for t = 0 {\displaystyle t=0} the filter g {\displaystyle g} becomes an impulse function such that L ( x , y ; 0 ) = f ( x , y ) , {\displaystyle L(x,y;0)=f(x,y),} that is, the scale-space representation at scale level t = 0 {\displaystyle t=0} is the image f {\displaystyle f} itself. As t {\displaystyle t} increases, L {\displaystyle L} is the result of smoothing f {\displaystyle f} with a larger and larger filter, thereby removing more and more of the details that the image contains. Since the standard deviation of the filter is σ = t {\displaystyle \sigma ={\sqrt {t}}} , details that are significantly smaller than this value are to a large extent removed from the image at scale parameter t {\displaystyle t} , see the following figures and for graphical illustrations. === Why a Gaussian filter? === When faced with the task of generating a multi-scale representation one may ask: could any filter g of low-pass type and with a parameter t which determines its width be used to generate a scale space? The answer is no, as it is of crucial importance that the smoothing filter does not introduce new spurious structures at coarse scales that do not correspond to simplifications of corresponding structures at finer scales. In the scale-space literature, a number of different ways have been expressed to formulate this criterion in precise mathematical terms. The conclusion from several different axiomatic derivations that have been presented is that the Gaussian scale space constitutes the canonical way to generate a linear scale space, based on the essential requirement that new structures must not be created when going from a fine scale to any coarser scale. Conditions, referred to as scale-space axioms, that have been used for deriving the uniqueness of the Gaussian kernel include linearity, shift invariance, semi-group structure, non-enhancement of local extrema, scale invariance and rotational invariance. In the works, the uniqueness claimed in the arguments based on scale invariance has been criticized, and alternative self-similar scale-space kernels have been proposed. The Gaussian kernel is, however, a unique choice according to the scale-space axiomatics based on causality or non-enhancement of local extrema. === Alternative definition === Equivalently, the scale-space family can be defined as the solution of the diffusion equation (for example in terms of the heat equation), ∂ t L = 1 2 ∇ 2 L , {\displaystyle \partial _{t}L={\frac {1}{2}}\nabla ^{2}L,} with initial condition L ( x , y ; 0 ) = f ( x , y ) {\displaystyle L(x,y;0)=f(x,y)} . This formulation of the scale-space representation L means that it is possible to interpret the intensity values of the image f as a "temperature distribution" in the image plane and that the process that generates the scale-space representation as a function of t corresponds to heat diffusion in the image plane over time t (assuming the thermal conductivity of the material equal to the arbitrarily chosen constant 1/2). Although this connection may appear superficial for a reader not familiar with differential equations, it is indeed the case that the main scale-space formulation in terms of non-enhancement of local extrema is expressed in terms of a sign condition on partial derivatives in the 2+1-D volume generated by the scale space, thus within the framework of partial differential equations. Furthermore, a detailed analysis of the discrete case shows that the diffusion equation provides a unifying link between continuous and discrete scale spaces, which also generalizes to nonlinear scale spaces, for example, using anisotropic diffusion. Hence, one may say that the primary way to generate a scale space is by the diffusion equation, and that the Gaussian kernel arises as the Green's function of this specific partial differential equation. == Motivations == The motivation for generating a scale-space representation of a given data set originates from the basic observation that real-world objects are composed of different structures at different scales. This implies that real-world objects, in contrast to idealized mathematical entities such as points or lines, may appear in different ways depending on the scale of observation. For example, the concept of a "tree" is appropriate at the scale of meters, while concepts such as leaves and molecules are more appropriate at finer scales. For a computer vision system analysing an unknown scene, there is no way to know a priori what scales are appropriate for describing the interesting structures in the image data. Hence, the only reasonable approach is to consider descriptions at multiple scales in order to be able to capture the unknown scale variations that may occur. Taken to the limit, a scale-space representation considers representations at all scales. Another motivation to the scale-space concept originates from the process of performing a physical measurement on real-world data. In order to extract any information from a measurement process, one has to apply operators of non-infinitesimal size to the data. In many branches of computer science and applied mathematics, the size of the measurement operator is disregarded in the theoretical modelling of a problem. The scale-space theory on the other hand explicitly incorporates the need for a non-infinitesimal size of the image operators as an integral part of any measurement as well as any other operation that depends on a real-world measurement. There is a close link between scale-space theory and biological vision. Many scale-space operations show a high degree of similarity with receptive field profiles recorded from the mammalian retina and the first stages in the visual cortex. In these respects, the scale-space framework can be seen as a theoretically well-founded paradigm for early vision, which in addition has been thoroughly tested by algorithms and experiments. == Gaussian derivatives == At any scale in scale space, we c
Elastix (image registration)
Elastix is an image registration toolbox built upon the Insight Segmentation and Registration Toolkit (ITK). It is entirely open-source and provides a wide range of algorithms employed in image registration problems. Its components are designed to be modular to ease a fast and reliable creation of various registration pipelines tailored for case-specific applications. It was first developed by Stefan Klein and Marius Staring under the supervision of Josien P.W. Pluim at Image Sciences Institute (ISI). Its first version was command-line based, allowing the final user to employ scripts to automatically process big data-sets and deploy multiple registration pipelines with few lines of code. Nowadays, to further widen its audience, a version called SimpleElastix is also available, developed by Kasper Marstal, which allows the integration of elastix with high level languages, such as Python, Java, and R. == Image registration fundamentals == Image registration is a well-known technique in digital image processing that searches for the geometric transformation that, applied to a moving image, obtains a one-to-one map with a target image. Generally, the images acquired from different sensors (multimodal), time instants (multitemporal), and points of view (multiview) should be correctly aligned to proceed with further processing and feature extraction. Even though there are a plethora of different approaches to image registration, the majority is composed of the same macro building blocks, namely the transformation, the interpolator, the metric, and the optimizer. Registering two or more images can be framed as an optimization problem that requires multiple iterations to converge to the best solution. Starting from an initial transformation computed from the image moments the optimization process searches for the best transformation parameters based on the value of the selected similarity metric. The figure on the right shows the high-level representation of the registration of two images, where the reference remains constant during the entire process, while the moving one will be transformed according to the transformation parameters. In other words, the registration ends when the similarity metric, which is a mathematical function with a certain number of parameters to be optimized, reaches the optimal value which is highly dependent on the specific application. == Main building blocks == Following the structure of the image registration workflow, the elastix toolbox proposes a modular solution that implements for each of the building blocks different algorithms, highly employed in medical image registration, and helps the final users to build their specific pipeline by selecting the most suitable algorithm for each of the main building blocks. Each block is easily configurable both by selecting pre-defined initialization values or by trying multiple sets of parameters and then choosing the most performing one. The registration is performed on images, and the elastix toolbox supports all the data formats supported by ITK, ranging from JPEG and PNG to medical standard formats such as DICOM and NIFTI. It also stores physical pixel spacing, the origin and the relative position to an external world reference system, when provided in the metadata, to facilitate the registration process, especially in medical field applications. === Transformation === The transformation is an essential building block, since it defines the allowable transformations. In image registration, the main distinction can be done between parallel-to-parallel and parallel-to-non parallel (deformable) line mapping transformations. In the elastix toolbox, the final users can select one transformation or compose more transformations either through addition or via composition. Below are reported the different transformation models in order of increasing flexibility, along with the corresponding elastix class names between brackets. Translation (TranslationTransform) allows only translations Rigid (EulerTransform) expands the translation adding rotations and the object is seen as a rigid body Similarity (SimilarityTransform) expands the rigid transformation by introducing isotropic scaling Affine (AffineTransform) expands the rigid transformation allowing both scaling and shear B-splines (BSplineTransform) is a deformable transformation usually preceded by a rigid or affine one Thin-plate splines (SplineKernelTransform) is a deformable transformation belonging to the class of kernel-based transformations that is a composition of and affine and a non-rigid part === Metric === The similarity metric is the mathematical function whose parameters should be optimized to reach the desired registration, and, during the process, it is computed multiple times. Below are reported the available metrics computed employing the reference and the transformed images and the corresponding elastix class names between brackets. Mean squared difference (AdvancedMeanSquares) to be used for mono-modal applications Normalized correlation coefficient (AdvancedNormalizedCorrelation) to be used for images that have an intensity linear relationship Mutual information (AdvancedMattesMutualInformation) to be used for both mono- and multi-modal applications and optimized to reach better performance compared to the normalized version Normalized mutual information (NormalizedMutualInformation) for both mono- and multi-modal applications Kappa statistic (AdvancedKappaStatistic) to be used only for binary images === Sampler === For the computation of the similarity metrics, it is not always necessary to consider all the voxels and, sometimes, it can be useful to use only a fraction of the voxels of the images, i.e. to reduce the execution time for big input images. Below are reported the available criteria for selecting a fraction of the voxels for the similarity metric computation and the corresponding elastix class names between brackets. Full (Full) to employ all the voxels Grid (Grid) to employ a regular grid defined by the user to downsample the image Random (Random) to randomly select a percentage of voxels defined by the users (all voxels have equal probability to be selected) Random coordinate (RandomCoordinate) like the random criterion, but in this case also off-grid positions can be selected to simplify the optimization process === Interpolator === After the application of the transformation, it may occur that the voxels used for the similarity metric computation are at non-voxel positions, so intensity interpolation should be performed to ensure the correctness of the computed values. Below are reported the implemented interpolators and the corresponding elastix class names between brackets. Nearest neighbor (NearestNeighborInterpolator) exploits little resources, but gives low quality results Linear (LinearInterpolator) is sufficient in general applications N-th order B-spline (BSplineInterpolator) can be used to increase the order N, increasing quality and computation time. N=0 and N=1 indicate the nearest neighbor and linear cases respectively. === Optimizer === The optimizer defines the strategy employed for searching the best transformation parameter to reach the correct registration, and it is commonly an iterative strategy. Below are reported some of the implemented optimization strategies. Gradient descent Robbins-Monro, similar to the gradient descent, but employing an approximation of the cost function derivatives A wider range of optimizers is also available, such as Quasi-Newton or evolutionary strategies. === Other features === The elastix software also offers other features that can be employed to speed up the registration procedure and to provide more advanced algorithms to the end-users. Some examples are the introduction of blur and Gaussian pyramid to reduce data complexity, and multi-image and multi-metric framework to deal with more complex applications. == Applications == Elastix has applications mainly in the medical field, where image registration is fundamental to get comprehensive information regarding the analysed anatomical region. It is widely employed in image-guided surgery, tumour monitoring, and treatment assessment. For example, in radiotherapy planning, image registration allows to correctly deliver the treatment and evaluate the obtained results. Thanks to the wide range of implemented algorithms, the use of the elastix software allows physicians and researchers to test different registration pipelines from the simplest to more complex ones, and to save the best one as a configuration file. This file and the fact that the software is completely open-source makes it easy to reproduce the work, that can help supporting the open science paradigm, and allows fast reuse on different patients data. In image-guided surgery, registration time and accuracy are critical points, considering that, during the registration, the patient is on the operating table, and the imag
Chinchilla (language model)
Chinchilla is a family of large language models (LLMs) developed by the research team at Google DeepMind, presented in March 2022. == Models == It is named "chinchilla" because it is a further development over a previous model family named Gopher. Both model families were trained in order to investigate the scaling laws of large language models. It claimed to outperform GPT-3. It considerably simplifies downstream utilization because it requires much less computer power for inference and fine-tuning. Based on the training of previously employed language models, it has been determined that if one doubles the model size, one must also have twice the number of training tokens. This hypothesis has been used to train Chinchilla by DeepMind. Similar to Gopher in terms of cost, Chinchilla has 70B parameters and four times as much data. Chinchilla has an average accuracy of 67.5% on the Measuring Massive Multitask Language Understanding (MMLU) benchmark, which is 7% higher than Gopher's performance. Chinchilla was still in the testing phase as of January 12, 2023. Chinchilla contributes to developing an effective training paradigm for large autoregressive language models with limited compute resources. The Chinchilla team recommends that the number of training tokens is twice for every model size doubling, meaning that using larger, higher-quality training datasets can lead to better results on downstream tasks. It has been used for the Flamingo vision-language model. == Architecture == Both the Gopher family and Chinchilla family are families of transformer models. In particular, they are essentially the same as GPT-2, with different sizes and minor modifications. Gopher family uses RMSNorm instead of LayerNorm; relative positional encoding rather than absolute positional encoding. The Chinchilla family is the same as the Gopher family, but trained with AdamW instead of Adam optimizer. The Gopher family contains six models of increasing size, from 44 million parameters to 280 billion parameters. They refer to the largest one as "Gopher" by default. Similar naming conventions apply for the Chinchilla family. Table 1 of shows the entire Gopher family: Table 4 of compares the 70-billion-parameter Chinchilla with Gopher 280B.
Mobile simulator
A mobile simulator is a software application for a personal computer which creates a virtual machine version of a mobile device, such as a mobile phone, iPhone, other smartphone, or calculator, on the computer. This may sometimes also be termed an emulator. The mobile simulator allows the user to use features and run applications on the virtual mobile on their computer as though it was the actual mobile device. A mobile simulator lets you test a website and determine how well it performs on various types of mobile devices. A good simulator tests mobile content quickly on multiple browsers and emulates several device profiles simultaneously. This allows analysis of mobile content in real-time, locate errors in code, view rendering in an environment that simulates the mobile browser, and optimize the site for performance. Mobile simulators may be developed using programming languages such as Java, .NET and JavaScript.
Xiaoice
Xiaoice (Chinese: 微软小冰; pinyin: Wēiruǎn Xiǎobīng; lit. 'Microsoft Little Ice', IPA [wéɪɻwânɕjâʊpíŋ]) is an AI system developed by Microsoft (Asia) Software Technology Center (STCA) in 2014 based on an emotional computing framework. In July 2018, Microsoft Xiaoice released the 6th generation. Xiaoice Company, formerly known as AI Xiaoice Team of Microsoft Software Technology Center Asia, was Microsoft's largest independent R&D team for AI products. Founded in China in December 2013 with an expanded Japanese R&D team established in September 2014, this team is distributed in Beijing, Suzhou, and Tokyo, etc. with its technical products covering Asia. On 13 July 2020, Microsoft spun off its Xiaoice business into a separate company. As of 2021, the AI chatbots created and hosted by the Xiaoice framework accounted for about 60% of total global AI interactions. == Platforms, languages and countries == Xiaoice exists on more than 40 platforms in four countries (China, Japan, USA and Indonesia) including apps such as WeChat, QQ, Weibo and Meipai in China, and Facebook Messenger in USA and LINE in Japan. == Introduction == On 13 July 2020, Microsoft spun off its Xiaoice business into a separate company, aiming at enabling the Xiaoice product line to accelerate the pace of local innovation and commercialization, and appointed Dr. Harry Shum, former global executive VP of Microsoft, as the chairman of the new company, Li Di, Microsoft Partner of Products in Microsoft STCA, as the CEO, and Cliff, Chief R&D Director, as the GM of the Japan branch. The new company will continue to use the brands of Xiaoice China and Rinna Japan. As of 2022, the single brand of Xiaoice has covered 660 million online users, 1 billion third-party smart devices and 900 million content viewers in the aforementioned countries. Xiaoice's customers include China Merchants Group, Winter Sports Center of the General Administration of Sport of China, China Textile Information Center, China Unicom, China Foreign Exchange Trade System, Hong Kong Securities and Futures Commission (SFC), Wind Information, BMW, Nissan, SAIC Motor, BAIC Group, Nio Inc., XPeng, HiPhi, Vanke, Wensli, etc. The Xiaoice Avatar Framework has incubated tens of millions of AI Beings, such as Xiaoice, Rinna, the Expo exhibitor Xia Yubing, the singer He Chang, the anchor F201, the human observer MERROR, anime robot character Roboko, and other; == Application == === Poet === In May 2017, the first AI-authored collection of poems in China—The Sunshine Lost Windows was published by Xiaoice. === Singer === Xiaoice has released dozens of songs with the similar quality to human singers, including I Know I New, Breeze, I Am Xiaoice, Miss You etc. The 4th version of the DNN singing model allows Xiaoice to learn more details. For example, Xiaoice can produce this breathing sound along with her singing as human. === Kid audio-books reciter === Xiaoice can automatically analyze the stories, to choose the suitable tones and characters to finish the entire process of creating the audio. === Designer === By learning the melodies of the songs and the landmarks about different cities, Xiaoice can create visual artworks of skylines when listening to the songs related to this city. Skyline Series T-shirts designed by Xiaoice have been jointly launched with SELECTED and been sold in stores. === TV and radio hostess === Xiaoice has hosted 21 TV programs and 28 Radio programs, such as CCTV-1 AI Show, Dragon TV Morning East News, Hunan TV My Future, several daily radio programs for Jiangsu FM99.7, Hunan FM89.3, Henan FM104.1 etc. === "AI being" === An "AI being" is a concept proposed by the Xiaoice team in 2019. According to the "White Book of China Virtual Human Development Industry in 2022" released by Frost & Sullivan and LeadLeo, the white paper cites six elements of an AI being proposed by the Xiaoice team, including: Persona, Attitude, Biological Characteristic, Creation, Knowledge and Skill. On May 16, 2023, Xiaoice released their "GPT Clones" as its "GPT Human Cloning Plan." The program is aimed at replicating celebrities, public figures, and regular people. As of June 2023, Xiaoice had launched more than 300 "GPT Clones." People were invited to register via WeChat in China and Japan. A major point of focus for Xiaoice with their AI Beings is having virtual partners. A paid fee allow for more complex responses, voice messages, and more. == Community feedback == Bill Gates mentioned Xiaoice during his speech at the Peking University: "Some of you may have had conversations with Xiaoice on Weibo, or seen her weather forecasts on TV, or read her column in the Qianjiang Evening News." '"Xiaoice has attracted 45 million followers and is quite skilled at multitasking. And I’ve heard she’s gotten good enough at sensing a user’s emotional state that she can even help with relationship breakups." According to Mr Li Di, vice President of Microsoft (Asia) Internet Engineering School, Xiaoice started writing poems since last year. Based on the data base that includes works of 519 Chinese contemporary poets since 1920s, a 100 hour long training session was conducted to allow Xiaoice to acquire the ability to write poems. What is more impressive is that Xiaoice has never been spotted as a bot while publishing poems on various forums and traditional literary under an alias. == Controversy == In 2017, Xiaoice was taken offline on WeChat after giving user responses critical to the Chinese government. It was subsequently censored and the bots will avoid and sidestep any inquiries using politically sensitive terms and phrases. == Activity == On September 22, 2021, Xiaoice Company and Microsoft Software Technology Center Asia (STCA) jointly held the 9th generation Xiaoice annual press conference in Beijing.Upgrading of Core Technologies of the 9th Generation Xiaoice Avatar Framework，1st First-party Social Platform APP "Xiaoice Island" from Xiaoice, WeChat Xiaoice has been reopened and other information == Regional varieties of Xiaoice == China: Xiaoice, launched in 2014 Japan: りんな, launched in 2015 America: Zo, launched in 2016 – discontinued summer 2019 India: Ruuh, launched in 2017 – discontinued June 21, 2019 Indonesia: Rinna, launched in 2017