Multifactor dimensionality reduction (MDR) is a statistical approach, also used in machine learning automatic approaches, for detecting and characterizing combinations of attributes or independent variables that interact to influence a dependent or class variable. MDR was designed specifically to identify nonadditive interactions among discrete variables that influence a binary outcome and is considered a nonparametric and model-free alternative to traditional statistical methods such as logistic regression. The basis of the MDR method is a constructive induction or feature engineering algorithm that converts two or more variables or attributes to a single attribute. This process of constructing a new attribute changes the representation space of the data. The end goal is to create or discover a representation that facilitates the detection of nonlinear or nonadditive interactions among the attributes such that prediction of the class variable is improved over that of the original representation of the data. == Illustrative example == Consider the following simple example using the exclusive OR (XOR) function. XOR is a logical operator that is commonly used in data mining and machine learning as an example of a function that is not linearly separable. The table below represents a simple dataset where the relationship between the attributes (X1 and X2) and the class variable (Y) is defined by the XOR function such that Y = X1 XOR X2. Table 1 A machine learning algorithm would need to discover or approximate the XOR function in order to accurately predict Y using information about X1 and X2. An alternative strategy would be to first change the representation of the data using constructive induction to facilitate predictive modeling. The MDR algorithm would change the representation of the data (X1 and X2) in the following manner. MDR starts by selecting two attributes. In this simple example, X1 and X2 are selected. Each combination of values for X1 and X2 are examined and the number of times Y=1 and/or Y=0 is counted. In this simple example, Y=1 occurs zero times and Y=0 occurs once for the combination of X1=0 and X2=0. With MDR, the ratio of these counts is computed and compared to a fixed threshold. Here, the ratio of counts is 0/1 which is less than our fixed threshold of 1. Since 0/1 < 1 we encode a new attribute (Z) as a 0. When the ratio is greater than one we encode Z as a 1. This process is repeated for all unique combinations of values for X1 and X2. Table 2 illustrates our new transformation of the data. Table 2 The machine learning algorithm now has much less work to do to find a good predictive function. In fact, in this very simple example, the function Y = Z has a classification accuracy of 1. A nice feature of constructive induction methods such as MDR is the ability to use any data mining or machine learning method to analyze the new representation of the data. Decision trees, neural networks, or a naive Bayes classifier could be used in combination with measures of model quality such as balanced accuracy and mutual information. == Machine learning with MDR == As illustrated above, the basic constructive induction algorithm in MDR is very simple. However, its implementation for mining patterns from real data can be computationally complex. As with any machine learning algorithm there is always concern about overfitting. That is, machine learning algorithms are good at finding patterns in completely random data. It is often difficult to determine whether a reported pattern is an important signal or just chance. One approach is to estimate the generalizability of a model to independent datasets using methods such as cross-validation. Models that describe random data typically don't generalize. Another approach is to generate many random permutations of the data to see what the data mining algorithm finds when given the chance to overfit. Permutation testing makes it possible to generate an empirical p-value for the result. Replication in independent data may also provide evidence for an MDR model but can be sensitive to difference in the data sets. These approaches have all been shown to be useful for choosing and evaluating MDR models. An important step in a machine learning exercise is interpretation. Several approaches have been used with MDR including entropy analysis and pathway analysis. Tips and approaches for using MDR to model gene-gene interactions have been reviewed. == Extensions to MDR == Numerous extensions to MDR have been introduced. These include family-based methods, fuzzy methods, covariate adjustment, odds ratios, risk scores, survival methods, robust methods, methods for quantitative traits, and many others. == Applications of MDR == MDR has mostly been applied to detecting gene-gene interactions or epistasis in genetic studies of common human diseases such as atrial fibrillation, autism, bladder cancer, breast cancer, cardiovascular disease, hypertension, obesity, pancreatic cancer, prostate cancer and tuberculosis. It has also been applied to other biomedical problems such as the genetic analysis of pharmacology outcomes. A central challenge is the scaling of MDR to big data such as that from genome-wide association studies (GWAS). Several approaches have been used. One approach is to filter the features prior to MDR analysis. This can be done using biological knowledge through tools such as BioFilter. It can also be done using computational tools such as ReliefF. Another approach is to use stochastic search algorithms such as genetic programming to explore the search space of feature combinations. Yet another approach is a brute-force search using high-performance computing. == Implementations == www.epistasis.org provides an open-source and freely-available MDR software package. An R package for MDR. An sklearn-compatible Python implementation. An R package for Model-Based MDR. MDR in Weka. Generalized MDR.
Anthrobotics
Anthrobotics is the science of developing and studying robots that are either entirely or in some way human-like. The term anthrobotics was originally coined by Mark Rosheim in a paper entitled "Design of An Omnidirectional Arm" presented at the IEEE International Conference on Robotics and Automation, May 13–18, 1990, pp. 2162–2167. Rosheim says he derived the term from "...Anthropomorphic and Robotics to distinguish the new generation of dexterous robots from its simple industrial robot forebears." The word gained wider recognition as a result of its use in the title of Rosheim's subsequent book Robot Evolution: The Development of Anthrobotics, which focussed on facsimiles of human physical and psychological skills and attributes. However, a wider definition of the term anthrobotics has been proposed, in which the meaning is derived from anthropology rather than anthropomorphic. This usage includes robots that respond to input in a human-like fashion, rather than simply mimicking human actions, thus theoretically being able to respond more flexibly or to adapt to unforeseen circumstances. This expanded definition also encompasses robots that are situated in social environments with the ability to respond to those environments appropriately, such as insect robots, robotic pets, and the like. Anthrobotics is now taught at some universities, encouraging students not only to design and build robots for environments beyond current industrial applications, but also to speculate on the future of robotics that are embedded in the world at large, as mobile phones and computers are today. In 2016 philosopher Luis de Miranda created the Anthrobotics Cluster at the University of Edinburgh "a platform of cross-disciplinary research that seeks to investigate some of the biggest questions that will need to be answered" on the relationship between humans, robots and intelligent systems and "a think tank on the social spread of robotics, and also how automation is part of the definition of what humans have always been". to explore the symbiotic relationship between humans and automated protocols.
Kernel method
In machine learning, kernel machines are a class of algorithms for pattern analysis, whose best known member is the support-vector machine (SVM). These methods involve using linear classifiers to solve nonlinear problems. The general task of pattern analysis is to find and study general types of relations (for example clusters, rankings, principal components, correlations, classifications) in datasets. For many algorithms that solve these tasks, the data in raw representation have to be explicitly transformed into feature vector representations via a user-specified feature map: in contrast, kernel methods require only a user-specified kernel, i.e., a similarity function over all pairs of data points computed using inner products. The feature map in kernel machines is infinite dimensional but only requires a finite dimensional matrix from user-input according to the representer theorem. Kernel machines are slow to compute for datasets larger than a couple of thousand examples without parallel processing. Kernel methods owe their name to the use of kernel functions, which enable them to operate in a high-dimensional, implicit feature space without ever computing the coordinates of the data in that space, but rather by simply computing the inner products between the images of all pairs of data in the feature space. This operation is often computationally cheaper than the explicit computation of the coordinates. This approach is called the "kernel trick". Kernel functions have been introduced for sequence data, graphs, text, images, as well as vectors. Algorithms capable of operating with kernels include the kernel perceptron, support-vector machines (SVM), Gaussian processes, principal components analysis (PCA), canonical correlation analysis, ridge regression, spectral clustering, linear adaptive filters and many others. Most kernel algorithms are based on convex optimization or eigenproblems and are statistically well-founded. Typically, their statistical properties are analyzed using statistical learning theory (for example, using Rademacher complexity). == Motivation and informal explanation == Kernel methods can be thought of as instance-based learners: rather than learning some fixed set of parameters corresponding to the features of their inputs, they instead "remember" the i {\displaystyle i} -th training example ( x i , y i ) {\displaystyle (\mathbf {x} _{i},y_{i})} and learn for it a corresponding weight w i {\displaystyle w_{i}} . Prediction for unlabeled inputs, i.e., those not in the training set, are treated by the application of a similarity function k {\displaystyle k} , called a kernel, between the unlabeled input x ′ {\displaystyle \mathbf {x'} } and each of the training inputs x i {\displaystyle \mathbf {x} _{i}} . For instance, a kernelized binary classifier typically computes a weighted sum of similarities y ^ = sgn ∑ i = 1 n w i y i k ( x i , x ′ ) , {\displaystyle {\hat {y}}=\operatorname {sgn} \sum _{i=1}^{n}w_{i}y_{i}k(\mathbf {x} _{i},\mathbf {x'} ),} where y ^ ∈ { − 1 , + 1 } {\displaystyle {\hat {y}}\in \{-1,+1\}} is the kernelized binary classifier's predicted label for the unlabeled input x ′ {\displaystyle \mathbf {x'} } whose hidden true label y {\displaystyle y} is of interest; k : X × X → R {\displaystyle k\colon {\mathcal {X}}\times {\mathcal {X}}\to \mathbb {R} } is the kernel function that measures similarity between any pair of inputs x , x ′ ∈ X {\displaystyle \mathbf {x} ,\mathbf {x'} \in {\mathcal {X}}} ; the sum ranges over the n labeled examples { ( x i , y i ) } i = 1 n {\displaystyle \{(\mathbf {x} _{i},y_{i})\}_{i=1}^{n}} in the classifier's training set, with y i ∈ { − 1 , + 1 } {\displaystyle y_{i}\in \{-1,+1\}} ; the w i ∈ R {\displaystyle w_{i}\in \mathbb {R} } are the weights for the training examples, as determined by the learning algorithm; the sign function sgn {\displaystyle \operatorname {sgn} } determines whether the predicted classification y ^ {\displaystyle {\hat {y}}} comes out positive or negative. Kernel classifiers were described as early as the 1960s, with the invention of the kernel perceptron. They rose to great prominence with the popularity of the support-vector machine (SVM) in the 1990s, when the SVM was found to be competitive with neural networks on tasks such as handwriting recognition. == Mathematics: the kernel trick == The kernel trick avoids the explicit mapping that is needed to get linear learning algorithms to learn a nonlinear function or decision boundary. For all x {\displaystyle \mathbf {x} } and x ′ {\displaystyle \mathbf {x'} } in the input space X {\displaystyle {\mathcal {X}}} , certain functions k ( x , x ′ ) {\displaystyle k(\mathbf {x} ,\mathbf {x'} )} can be expressed as an inner product in another space V {\displaystyle {\mathcal {V}}} . The function k : X × X → R {\displaystyle k\colon {\mathcal {X}}\times {\mathcal {X}}\to \mathbb {R} } is often referred to as a kernel or a kernel function. The word "kernel" is used in mathematics to denote a weighting function for a weighted sum or integral. Certain problems in machine learning have more structure than an arbitrary weighting function k {\displaystyle k} . The computation is made much simpler if the kernel can be written in the form of a "feature map" φ : X → V {\displaystyle \varphi \colon {\mathcal {X}}\to {\mathcal {V}}} which satisfies k ( x , x ′ ) = ⟨ φ ( x ) , φ ( x ′ ) ⟩ V . {\displaystyle k(\mathbf {x} ,\mathbf {x'} )=\langle \varphi (\mathbf {x} ),\varphi (\mathbf {x'} )\rangle _{\mathcal {V}}.} The key restriction is that ⟨ ⋅ , ⋅ ⟩ V {\displaystyle \langle \cdot ,\cdot \rangle _{\mathcal {V}}} must be a proper inner product. On the other hand, an explicit representation for φ {\displaystyle \varphi } is not necessary, as long as V {\displaystyle {\mathcal {V}}} is an inner product space. The alternative follows from Mercer's theorem: an implicitly defined function φ {\displaystyle \varphi } exists whenever the space X {\displaystyle {\mathcal {X}}} can be equipped with a suitable measure ensuring the function k {\displaystyle k} satisfies Mercer's condition. Mercer's theorem is similar to a generalization of the result from linear algebra that associates an inner product to any positive-definite matrix. In fact, Mercer's condition can be reduced to this simpler case. If we choose as our measure the counting measure μ ( T ) = | T | {\displaystyle \mu (T)=|T|} for all T ⊂ X {\displaystyle T\subset X} , which counts the number of points inside the set T {\displaystyle T} , then the integral in Mercer's theorem reduces to a summation ∑ i = 1 n ∑ j = 1 n k ( x i , x j ) c i c j ≥ 0. {\displaystyle \sum _{i=1}^{n}\sum _{j=1}^{n}k(\mathbf {x} _{i},\mathbf {x} _{j})c_{i}c_{j}\geq 0.} If this summation holds for all finite sequences of points ( x 1 , … , x n ) {\displaystyle (\mathbf {x} _{1},\dotsc ,\mathbf {x} _{n})} in X {\displaystyle {\mathcal {X}}} and all choices of n {\displaystyle n} real-valued coefficients ( c 1 , … , c n ) {\displaystyle (c_{1},\dots ,c_{n})} (cf. positive definite kernel), then the function k {\displaystyle k} satisfies Mercer's condition. Some algorithms that depend on arbitrary relationships in the native space X {\displaystyle {\mathcal {X}}} would, in fact, have a linear interpretation in a different setting: the range space of φ {\displaystyle \varphi } . The linear interpretation gives us insight about the algorithm. Furthermore, there is often no need to compute φ {\displaystyle \varphi } directly during computation, as is the case with support-vector machines. Some cite this running time shortcut as the primary benefit. Researchers also use it to justify the meanings and properties of existing algorithms. Theoretically, a Gram matrix K ∈ R n × n {\displaystyle \mathbf {K} \in \mathbb {R} ^{n\times n}} with respect to { x 1 , … , x n } {\displaystyle \{\mathbf {x} _{1},\dotsc ,\mathbf {x} _{n}\}} (sometimes also called a "kernel matrix"), where K i j = k ( x i , x j ) {\displaystyle K_{ij}=k(\mathbf {x} _{i},\mathbf {x} _{j})} , must be positive semi-definite (PSD). Empirically, for machine learning heuristics, choices of a function k {\displaystyle k} that do not satisfy Mercer's condition may still perform reasonably if k {\displaystyle k} at least approximates the intuitive idea of similarity. Regardless of whether k {\displaystyle k} is a Mercer kernel, k {\displaystyle k} may still be referred to as a "kernel". If the kernel function k {\displaystyle k} is also a covariance function as used in Gaussian processes, then the Gram matrix K {\displaystyle \mathbf {K} } can also be called a covariance matrix. == Applications == Application areas of kernel methods are diverse and include geostatistics, kriging, inverse distance weighting, 3D reconstruction, bioinformatics, cheminformatics, information extraction and handwriting recognition. == Popular kernels == Fisher kernel Graph kernels Kernel smoother Polynomial kernel Radial basis function kern
Randomized weighted majority algorithm
The randomized weighted majority algorithm is an algorithm in machine learning theory for aggregating expert predictions to a series of decision problems. It is a simple and effective method based on weighted voting which improves on the mistake bound of the deterministic weighted majority algorithm. In fact, in the limit, its prediction rate can be arbitrarily close to that of the best-predicting expert. == Example == Imagine that every morning before the stock market opens, we get a prediction from each of our "experts" about whether the stock market will go up or down. Our goal is to somehow combine this set of predictions into a single prediction that we then use to make a buy or sell decision for the day. The principal challenge is that we do not know which experts will give better or worse predictions. The RWMA gives us a way to do this combination such that our prediction record will be nearly as good as that of the single expert which, in hindsight, gave the most accurate predictions. == Motivation == In machine learning, the weighted majority algorithm (WMA) is a deterministic meta-learning algorithm for aggregating expert predictions. In pseudocode, the WMA is as follows: initialize all experts to weight 1 for each round: add each expert's weight to the option they predicted predict the option with the largest weighted sum multiply the weights of all experts who predicted wrongly by 1 2 {\displaystyle {\frac {1}{2}}} Suppose there are n {\displaystyle n} experts and the best expert makes m {\displaystyle m} mistakes. Then, the weighted majority algorithm (WMA) makes at most 2.4 ( log 2 n + m ) {\displaystyle 2.4(\log _{2}n+m)} mistakes. This bound is highly problematic in the case of highly error-prone experts. Suppose, for example, the best expert makes a mistake 20% of the time; that is, in N = 100 {\displaystyle N=100} rounds using n = 10 {\displaystyle n=10} experts, the best expert makes m = 20 {\displaystyle m=20} mistakes. Then, the weighted majority algorithm only guarantees an upper bound of 2.4 ( log 2 10 + 20 ) ≈ 56 {\displaystyle 2.4(\log _{2}10+20)\approx 56} mistakes. As this is a known limitation of the weighted majority algorithm, various strategies have been explored in order to improve the dependence on m {\displaystyle m} . In particular, we can do better by introducing randomization. Drawing inspiration from the Multiplicative Weights Update Method algorithm, we will probabilistically make predictions based on how the experts have performed in the past. Similarly to the WMA, every time an expert makes a wrong prediction, we will decrement their weight. Mirroring the MWUM, we will then use the weights to make a probability distribution over the actions and draw our action from this distribution (instead of deterministically picking the majority vote as the WMA does). == Randomized weighted majority algorithm (RWMA) == The randomized weighted majority algorithm is an attempt to improve the dependence of the mistake bound of the WMA on m {\displaystyle m} . Instead of predicting based on majority vote, the weights, are used as probabilities for choosing the experts in each round and are updated over time (hence the name randomized weighted majority). Precisely, if w i {\displaystyle w_{i}} is the weight of expert i {\displaystyle i} , let W = ∑ i w i {\displaystyle W=\sum _{i}w_{i}} . We will follow expert i {\displaystyle i} with probability w i W {\displaystyle {\frac {w_{i}}{W}}} . This results in the following algorithm: initialize all experts to weight 1. for each round: add all experts' weights together to obtain the total weight W {\displaystyle W} choose expert i {\displaystyle i} randomly with probability w i W {\displaystyle {\frac {w_{i}}{W}}} predict as the chosen expert predicts multiply the weights of all experts who predicted wrongly by β {\displaystyle \beta } The goal is to bound the worst-case expected number of mistakes, assuming that the adversary has to select one of the answers as correct before we make our coin toss. This is a reasonable assumption in, for instance, the stock market example provided above: the variance of a stock price should not depend on the opinions of experts that influence private buy or sell decisions, so we can treat the price change as if it was decided before the experts gave their recommendations for the day. The randomized algorithm is better in the worst case than the deterministic algorithm (weighted majority algorithm): in the latter, the worst case was when the weights were split 50/50. But in the randomized version, since the weights are used as probabilities, there would still be a 50/50 chance of getting it right. In addition, generalizing to multiplying the weights of the incorrect experts by β < 1 {\displaystyle \beta <1} instead of strictly 1 2 {\displaystyle {\frac {1}{2}}} allows us to trade off between dependence on m {\displaystyle m} and log 2 n {\displaystyle \log _{2}n} . This trade-off will be quantified in the analysis section. == Analysis == Let W t {\displaystyle W_{t}} denote the total weight of all experts at round t {\displaystyle t} . Also let F t {\displaystyle F_{t}} denote the fraction of weight placed on experts which predict the wrong answer at round t {\displaystyle t} . Finally, let N {\displaystyle N} be the total number of rounds in the process. By definition, F t {\displaystyle F_{t}} is the probability that the algorithm makes a mistake on round t {\displaystyle t} . It follows from the linearity of expectation that if M {\displaystyle M} denotes the total number of mistakes made during the entire process, E [ M ] = ∑ t = 1 N F t {\displaystyle E[M]=\sum _{t=1}^{N}F_{t}} . After round t {\displaystyle t} , the total weight is decreased by ( 1 − β ) F t W t {\displaystyle \ (1-\beta )F_{t}W_{t}} , since all weights corresponding to a wrong answer are multiplied by β < 1 {\displaystyle \ \beta <1} . It then follows that W t + 1 = W t ( 1 − ( 1 − β ) F t ) {\displaystyle W_{t+1}=W_{t}(1-(1-\beta )F_{t})} . By telescoping, since W 1 = n {\displaystyle W_{1}=n} , it follows that the total weight after the process concludes is On the other hand, suppose that m {\displaystyle \ m} is the number of mistakes made by the best-performing expert. At the end, this expert has weight β m {\displaystyle \ \beta ^{m}} . It follows, then, that the total weight is at least this much; in other words, W ≥ β m {\displaystyle \ W\geq \beta ^{m}} . This inequality and the above result imply Taking the natural logarithm of both sides yields Now, the Taylor series of the natural logarithm is In particular, it follows that ln ( 1 − ( 1 − β ) F t ) < − ( 1 − β ) F t {\displaystyle \ \ln(1-(1-\beta )F_{t})<-(1-\beta )F_{t}} . Thus, Recalling that E [ M ] = ∑ t = 1 N F t {\displaystyle E[M]=\sum _{t=1}^{N}F_{t}} and rearranging, it follows that Now, as β → 1 {\displaystyle \beta \to 1} from below, the first constant tends to 1 {\displaystyle 1} ; however, the second constant tends to + ∞ {\displaystyle +\infty } . To quantify this tradeoff, define ε = 1 − β {\displaystyle \varepsilon =1-\beta } to be the penalty associated with getting a prediction wrong. Then, again applying the Taylor series of the natural logarithm, It then follows that the mistake bound, for small ε {\displaystyle \varepsilon } , can be written in the form ( 1 + ϵ 2 + O ( ε 2 ) ) m + ϵ − 1 ln ( n ) {\displaystyle \ \left(1+{\frac {\epsilon }{2}}+O(\varepsilon ^{2})\right)m+\epsilon ^{-1}\ln(n)} . In English, the less that we penalize experts for their mistakes, the more that additional experts will lead to initial mistakes but the closer we get to capturing the predictive accuracy of the best expert as time goes on. In particular, given a sufficiently low value of ε {\displaystyle \varepsilon } and enough rounds, the randomized weighted majority algorithm can get arbitrarily close to the correct prediction rate of the best expert. In particular, as long as m {\displaystyle m} is sufficiently large compared to ln ( n ) {\displaystyle \ln(n)} (so that their ratio is sufficiently small), we can assign we can obtain an upper bound on the number of mistakes equal to This implies that the "regret bound" on the algorithm (that is, how much worse it performs than the best expert) is sublinear, at O ( m ln ( n ) ) {\displaystyle O({\sqrt {m\ln(n)}})} . == Revisiting the motivation == Recall that the motivation for the randomized weighted majority algorithm was given by an example where the best expert makes a mistake 20% of the time. Precisely, in N = 100 {\displaystyle N=100} rounds, with n = 10 {\displaystyle n=10} experts, where the best expert makes m = 20 {\displaystyle m=20} mistakes, the deterministic weighted majority algorithm only guarantees an upper bound of 2.4 ( log 2 10 + 20 ) ≈ 56 {\displaystyle 2.4(\log _{2}10+20)\approx 56} . By the analysis above, it follows that minimizing the number of worst-case expected mistakes is equivalent to minimizing the fun
Latent and observable variables
In statistics, latent variables (from Latin: present participle of lateo 'lie hidden') are variables that can only be inferred indirectly through a mathematical model from other observable variables that can be directly observed or measured. Such latent variable models are used in many disciplines, including engineering, medicine, ecology, physics, machine learning/artificial intelligence, natural language processing, bioinformatics, chemometrics, demography, economics, management, political science, psychology and the social sciences. Latent variables may correspond to aspects of physical reality. These could in principle be measured, but may not be for practical reasons. Among the earliest expressions of this idea is Francis Bacon's polemic the Novum Organum, itself a challenge to the more traditional logic expressed in Aristotle's Organon: But the latent process of which we speak, is far from being obvious to men’s minds, beset as they now are. For we mean not the measures, symptoms, or degrees of any process which can be exhibited in the bodies themselves, but simply a continued process, which, for the most part, escapes the observation of the senses. In this situation, the term hidden variables is commonly used, reflecting the fact that the variables are meaningful, but not observable. Other latent variables correspond to abstract concepts, like categories, behavioral or mental states, or data structures. The terms hypothetical variables or hypothetical constructs may be used in these situations. The use of latent variables can serve to reduce the dimensionality of data. Many observable variables can be aggregated in a model to represent an underlying concept, making it easier to understand the data. In this sense, they serve a function similar to that of scientific theories. At the same time, latent variables link observable "sub-symbolic" data in the real world to symbolic data in the modeled world. == Examples == === Psychology === Latent variables, as created by factor analytic methods, generally represent "shared" variance, or the degree to which variables "move" together. Variables that have no correlation cannot result in a latent construct based on the common factor model. The "Big Five personality traits" have been inferred using factor analysis. extraversion spatial ability wisdom: “Two of the more predominant means of assessing wisdom include wisdom-related performance and latent variable measures.” Spearman's g, or the general intelligence factor in psychometrics === Economics === Examples of latent variables from the field of economics include quality of life, business confidence, morale, happiness and conservatism: these are all variables which cannot be measured directly. However, by linking these latent variables to other, observable variables, the values of the latent variables can be inferred from measurements of the observable variables. Quality of life is a latent variable which cannot be measured directly, so observable variables are used to infer quality of life. Observable variables to measure quality of life include wealth, employment, environment, physical and mental health, education, recreation and leisure time, and social belonging. === Medicine === Latent-variable methodology is used in many branches of medicine. A class of problems that naturally lend themselves to latent variables approaches are longitudinal studies where the time scale (e.g. age of participant or time since study baseline) is not synchronized with the trait being studied. For such studies, an unobserved time scale that is synchronized with the trait being studied can be modeled as a transformation of the observed time scale using latent variables. Examples of this include disease progression modeling and modeling of growth (see box). == Inferring latent variables == There exists a range of different model classes and methodology that make use of latent variables and allow inference in the presence of latent variables. Models include: linear mixed-effects models and nonlinear mixed-effects models Hidden Markov models Factor analysis Item response theory Analysis and inference methods include: Principal component analysis Instrumented principal component analysis Partial least squares regression Latent semantic analysis and probabilistic latent semantic analysis EM algorithms Metropolis–Hastings algorithm === Bayesian algorithms and methods === Bayesian statistics is often used for inferring latent variables. Latent Dirichlet allocation The Chinese restaurant process is often used to provide a prior distribution over assignments of objects to latent categories. The Indian buffet process is often used to provide a prior distribution over assignments of latent binary features to objects.
Multiple satellite imaging
Multiple satellite imaging is the process of using multiple satellites to gather more information than a single satellite so that a better estimate of the desired source is possible. Something that cannot be resolved with one telescope might be visible with two or more telescopes. == Background == Interferometry is the process of combining waves in such a way that they constructively interfere. When two or more independent sources detect a signal at the same given frequency those signals can be combined and the result is better than each one individually. An overview of Astronomical interferometers and a History of astronomical interferometry can be referenced from their respective pages. The NASA Origins Program was created in the 1990s to ultimately search for the origin of the universe. The theory that the Origins Program is based on is: since light travels at a constant speed until it is absorbed by something; there is still light that was part of the first light ever created traveling about the universe and ultimately some of that light is coming in the general direction of Earth. So a satellite system capable of collecting light from the beginning of the universe would be able to tell us more about where we came from. There is also the constant search for life in other worlds. A satellite system using the interferometric technologies mentioned above would be able to have a much higher resolution than any of the current deep space imaging systems. == Future == NASA is currently focused on the Vision for Space Exploration and has reduced current funding for scientific unmanned space exploration in favor of human exploration. These budget cuts have slowed the multiple satellite imaging development and relevant scientific missions as Project Prometheus and Terrestrial Planet Finder have ended as well but research continues.
Oja's rule
Oja's learning rule, or simply Oja's rule, named after Finnish computer scientist Erkki Oja (Finnish pronunciation: [ˈojɑ], AW-yuh), is a model of how neurons in the brain or in artificial neural networks change connection strength, or learn, over time. It is a modification of the standard Hebb's Rule that, through multiplicative normalization, solves all stability problems and generates an algorithm for principal components analysis. This is a computational form of an effect which is believed to happen in biological neurons. == Theory == Oja's rule requires a number of simplifications to derive, but in its final form it is demonstrably stable, unlike Hebb's rule. It is a single-neuron special case of the Generalized Hebbian Algorithm. However, Oja's rule can also be generalized in other ways to varying degrees of stability and success. === Formula === Consider a simplified model of a neuron y {\displaystyle y} that returns a linear combination of its inputs x using presynaptic weights w: y ( x ) = ∑ j = 1 m x j w j {\displaystyle \,y(\mathbf {x} )~=~\sum _{j=1}^{m}x_{j}w_{j}} Oja's rule defines the change in presynaptic weights w given the output response y {\displaystyle y} of a neuron to its inputs x to be Δ w = w n + 1 − w n = η y n ( x n − y n w n ) , {\displaystyle \,\Delta \mathbf {w} ~=~\mathbf {w} _{n+1}-\mathbf {w} _{n}~=~\eta \,y_{n}(\mathbf {x} _{n}-y_{n}\mathbf {w} _{n}),} where η is the learning rate which can also change with time. Note that the bold symbols are vectors and n defines a discrete time iteration. The rule can also be made for continuous iterations as d w d t = η y ( t ) ( x ( t ) − y ( t ) w ( t ) ) . {\displaystyle \,{\frac {d\mathbf {w} }{dt}}~=~\eta \,y(t)(\mathbf {x} (t)-y(t)\mathbf {w} (t)).} === Derivation === The simplest learning rule known is Hebb's rule, which states in conceptual terms that neurons that fire together, wire together. In component form as a difference equation, it is written Δ w = η y ( x n ) x n {\displaystyle \,\Delta \mathbf {w} ~=~\eta \,y(\mathbf {x} _{n})\mathbf {x} _{n}} , or in scalar form with implicit n-dependence, w i ( n + 1 ) = w i ( n ) + η y ( x ) x i {\displaystyle \,w_{i}(n+1)~=~w_{i}(n)+\eta \,y(\mathbf {x} )x_{i}} , where y(xn) is again the output, this time explicitly dependent on its input vector x. Hebb's rule has synaptic weights approaching infinity with a positive learning rate. We can stop this by normalizing the weights so that each weight's magnitude is restricted between 0, corresponding to no weight, and 1, corresponding to being the only input neuron with any weight. We do this by normalizing the weight vector to be of length one: w i ( n + 1 ) = w i ( n ) + η y ( x ) x i ( ∑ j = 1 m [ w j ( n ) + η y ( x ) x j ] p ) 1 / p {\displaystyle \,w_{i}(n+1)~=~{\frac {w_{i}(n)+\eta \,y(\mathbf {x} )x_{i}}{\left(\sum _{j=1}^{m}[w_{j}(n)+\eta \,y(\mathbf {x} )x_{j}]^{p}\right)^{1/p}}}} . Note that in Oja's original paper, p=2, corresponding to quadrature (root sum of squares), which is the familiar Cartesian normalization rule. However, any type of normalization, even linear, will give the same result without loss of generality. For a small learning rate | η | ≪ 1 {\displaystyle |\eta |\ll 1} the equation can be expanded as a Power series in η {\displaystyle \eta } . w i ( n + 1 ) = w i ( n ) ( ∑ j w j p ( n ) ) 1 / p + η ( y x i ( ∑ j w j p ( n ) ) 1 / p − w i ( n ) ∑ j y x j w j p − 1 ( n ) ( ∑ j w j p ( n ) ) ( 1 + 1 / p ) ) + O ( η 2 ) {\displaystyle \,w_{i}(n+1)~=~{\frac {w_{i}(n)}{\left(\sum _{j}w_{j}^{p}(n)\right)^{1/p}}}~+~\eta \left({\frac {yx_{i}}{\left(\sum _{j}w_{j}^{p}(n)\right)^{1/p}}}-{\frac {w_{i}(n)\sum _{j}yx_{j}w_{j}^{p-1}(n)}{\left(\sum _{j}w_{j}^{p}(n)\right)^{(1+1/p)}}}\right)~+~O(\eta ^{2})} . For small η, our higher-order terms O(η2) go to zero. We again make the specification of a linear neuron, that is, the output of the neuron is equal to the sum of the product of each input and its synaptic weight to the power of p-1, which in the case of p=2 is synaptic weight itself, or y ( x ) = ∑ j = 1 m x j w j p − 1 {\displaystyle \,y(\mathbf {x} )~=~\sum _{j=1}^{m}x_{j}w_{j}^{p-1}} . We also specify that our weights normalize to 1, which will be a necessary condition for stability, so | w | = ( ∑ j = 1 m w j p ) 1 / p = 1 {\displaystyle \,|\mathbf {w} |~=~\left(\sum _{j=1}^{m}w_{j}^{p}\right)^{1/p}~=~1} , which, when substituted into our expansion, gives Oja's rule, or w i ( n + 1 ) = w i ( n ) + η y ( x i − w i ( n ) y ) {\displaystyle \,w_{i}(n+1)~=~w_{i}(n)+\eta \,y(x_{i}-w_{i}(n)y)} . === Stability and PCA === In analyzing the convergence of a single neuron evolving by Oja's rule, one extracts the first principal component, or feature, of a data set. Furthermore, with extensions using the Generalized Hebbian Algorithm, one can create a multi-Oja neural network that can extract as many features as desired, allowing for principal components analysis. A principal component aj is extracted from a dataset x through some associated vector qj, or aj = qj⋅x, and we can restore our original dataset by taking x = ∑ j a j q j {\displaystyle \mathbf {x} ~=~\sum _{j}a_{j}\mathbf {q} _{j}} . In the case of a single neuron trained by Oja's rule, we find the weight vector converges to q1, or the first principal component, as time or number of iterations approaches infinity. We can also define, given a set of input vectors Xi, that its correlation matrix Rij = XiXj has an associated eigenvector given by qj with eigenvalue λj. The variance of outputs of our Oja neuron σ2(n) = ⟨y2(n)⟩ then converges with time iterations to the principal eigenvalue, or lim n → ∞ σ 2 ( n ) = λ 1 {\displaystyle \lim _{n\rightarrow \infty }\sigma ^{2}(n)~=~\lambda _{1}} . These results are derived using Lyapunov function analysis, and they show that Oja's neuron necessarily converges on strictly the first principal component if certain conditions are met in our original learning rule. Most importantly, our learning rate η is allowed to vary with time, but only such that its sum is divergent but its power sum is convergent, that is ∑ n = 1 ∞ η ( n ) = ∞ , ∑ n = 1 ∞ η ( n ) p < ∞ , p > 1 {\displaystyle \sum _{n=1}^{\infty }\eta (n)=\infty ,~~~\sum _{n=1}^{\infty }\eta (n)^{p}<\infty ,~~~p>1} . Our output activation function y(x(n)) is also allowed to be nonlinear and nonstatic, but it must be continuously differentiable in both x and w and have derivatives bounded in time. == Applications == Oja's rule was originally described in Oja's 1982 paper, but the principle of self-organization to which it is applied is first attributed to Alan Turing in 1952. PCA has also had a long history of use before Oja's rule formalized its use in network computation in 1989. The model can thus be applied to any problem of self-organizing mapping, in particular those in which feature extraction is of primary interest. Therefore, Oja's rule has an important place in image and speech processing. It is also useful as it expands easily to higher dimensions of processing, thus being able to integrate multiple outputs quickly. A canonical example is its use in binocular vision. === Biology and Oja's subspace rule === There is clear evidence for both long-term potentiation and long-term depression in biological neural networks, along with a normalization effect in both input weights and neuron outputs. However, while there is no direct experimental evidence yet of Oja's rule active in a biological neural network, a biophysical derivation of a generalization of the rule is possible. Such a derivation requires retrograde signalling from the postsynaptic neuron, which is biologically plausible (see neural backpropagation), and takes the form of Δ w i j ∝ ⟨ x i y j ⟩ − ϵ ⟨ ( c p r e ∗ ∑ k w i k y k ) ⋅ ( c p o s t ∗ y j ) ⟩ , {\displaystyle \Delta w_{ij}~\propto ~\langle x_{i}y_{j}\rangle -\epsilon \left\langle \left(c_{\mathrm {pre} }\sum _{k}w_{ik}y_{k}\right)\cdot \left(c_{\mathrm {post} }y_{j}\right)\right\rangle ,} where as before wij is the synaptic weight between the ith input and jth output neurons, x is the input, y is the postsynaptic output, and we define ε to be a constant analogous the learning rate, and cpre and cpost are presynaptic and postsynaptic functions that model the weakening of signals over time. Note that the angle brackets denote the average and the ∗ operator is a convolution. By taking the pre- and post-synaptic functions into frequency space and combining integration terms with the convolution, we find that this gives an arbitrary-dimensional generalization of Oja's rule known as Oja's Subspace, namely Δ w = C x ⋅ w − w ⋅ C y . {\displaystyle \Delta w~=~Cx\cdot w-w\cdot Cy.}