A biohybrid microswimmer also known as biohybrid nanorobot, can be defined as a microswimmer that consist of both biological and artificial constituents, for instance, one or several living microorganisms attached to one or various synthetic parts. In recent years nanoscopic and mesoscopic objects have been designed to collectively move through direct inspiration from nature or by harnessing its existing tools. Small mesoscopic to nanoscopic systems typically operate at low Reynolds numbers (Re ≪ 1), and understanding their motion becomes challenging. For locomotion to occur, the symmetry of the system must be broken. In addition, collective motion requires a coupling mechanism between the entities that make up the collective. To develop mesoscopic to nanoscopic entities capable of swarming behaviour, it has been hypothesised that the entities are characterised by broken symmetry with a well-defined morphology, and are powered with some material capable of harvesting energy. If the harvested energy results in a field surrounding the object, then this field can couple with the field of a neighbouring object and bring some coordination to the collective behaviour. Such robotic swarms have been categorised by an online expert panel as among the 10 great unresolved group challenges in the area of robotics. Although investigation of their underlying mechanism of action is still in its infancy, various systems have been developed that are capable of undergoing controlled and uncontrolled swarming motion by harvesting energy (e.g., light, thermal, etc.). Over the past decade, biohybrid microrobots, in which living mobile microorganisms are physically integrated with untethered artificial structures, have gained growing interest to enable the active locomotion and cargo delivery to a target destination. In addition to the motility, the intrinsic capabilities of sensing and eliciting an appropriate response to artificial and environmental changes make cell-based biohybrid microrobots appealing for transportation of cargo to the inaccessible cavities of the human body for local active delivery of diagnostic and therapeutic agents. == Background == Biohybrid microswimmers can be defined as microswimmers that consist of both biological and artificial constituents, for instance, one or several living microorganisms attached to one or various synthetic parts. The pioneers of this field, ahead of their time, were Montemagno and Bachand with a 1999 work regarding specific attachment strategies of biological molecules to nanofabricated substrates enabling the preparation of hybrid inorganic/organic nanoelectromechanical systems, so called NEMS. They described the production of large amounts of F1-ATPase from the thermophilic bacteria Bacillus PS3 for the preparation of F1-ATPase biomolecular motors immobilized on a nanoarray pattern of gold, copper or nickel produced by electron beam lithography. These proteins were attached to one micron microspheres tagged with a synthetic peptide. Consequently, they accomplished the preparation of a platform with chemically active sites and the development of biohybrid devices capable of converting energy of biomolecular motors into useful work. One of the most fundamental questions in science is what defines life. Collective motion is one of the hallmarks of life. This is commonly observed in nature at various dimensional levels as energized entities gather, in a concerted effort, into motile aggregated patterns. These motile aggregated events can be noticed, among many others, as dynamic swarms; e.g., unicellular organisms such as bacteria, locust swarms, or the flocking behaviour of birds. Ever since Newton established his equations of motion, the mystery of motion on the microscale has emerged frequently in scientific history, as famously demonstrated by a couple of articles that should be discussed briefly. First, an essential concept, popularized by Osborne Reynolds, is that the relative importance of inertia and viscosity for the motion of a fluid depends on certain details of the system under consideration. The Reynolds number Re, named in his honor, quantifies this comparison as a dimensionless ratio of characteristic inertial and viscous forces: R e = ρ u l μ {\displaystyle \mathrm {Re} ={\frac {\rho ul}{\mu }}} Here, ρ represents the density of the fluid; u is a characteristic velocity of the system (for instance, the velocity of a swimming particle); l is a characteristic length scale (e.g., the swimmer size); and μ is the viscosity of the fluid. Taking the suspending fluid to be water, and using experimentally observed values for u, one can determine that inertia is important for macroscopic swimmers like fish (Re = 100), while viscosity dominates the motion of microscale swimmers like bacteria (Re = 10−4). The overwhelming importance of viscosity for swimming at the micrometer scale has profound implications for swimming strategy. This has been discussed memorably by E. M. Purcell, who invited the reader into the world of microorganisms and theoretically studied the conditions of their motion. In the first place, propulsion strategies of large scale swimmers often involve imparting momentum to the surrounding fluid in periodic discrete events, such as vortex shedding, and coasting between these events through inertia. This cannot be effective for microscale swimmers like bacteria: due to the large viscous damping, the inertial coasting time of a micron-sized object is on the order of 1 μs. The coasting distance of a microorganism moving at a typical speed is about 0.1 angstroms (Å). Purcell concluded that only forces that are exerted in the present moment on a microscale body contribute to its propulsion, so a constant energy conversion method is essential. Microorganisms have optimized their metabolism for continuous energy production, while purely artificial microswimmers (microrobots) must obtain energy from the environment, since their on-board-storage-capacity is very limited. As a further consequence of the continuous dissipation of energy, biological and artificial microswimmers do not obey the laws of equilibrium statistical physics, and need to be described by non-equilibrium dynamics. Mathematically, Purcell explored the implications of low Reynolds number by taking the Navier-Stokes equation and eliminating the inertial terms: μ ∇ 2 u − ∇ p = 0 {\displaystyle {\begin{aligned}\mu \nabla ^{2}\mathbf {u} -{\boldsymbol {\nabla }}p&={\boldsymbol {0}}\\\end{aligned}}} where u {\displaystyle \mathbf {u} } is the velocity of the fluid and ∇ p {\displaystyle {\boldsymbol {\nabla }}p} is the gradient of the pressure. As Purcell noted, the resulting equation — the Stokes equation — contains no explicit time dependence. This has some important consequences for how a suspended body (e.g., a bacterium) can swim through periodic mechanical motions or deformations (e.g., of a flagellum). First, the rate of motion is practically irrelevant for the motion of the microswimmer and of the surrounding fluid: changing the rate of motion will change the scale of the velocities of the fluid and of the microswimmer, but it will not change the pattern of fluid flow. Secondly, reversing the direction of mechanical motion will simply reverse all velocities in the system. These properties of the Stokes equation severely restrict the range of feasible swimming strategies. Recent publications of biohybrid microswimmers include the use of sperm cells, contractive muscle cells, and bacteria as biological components, as they can efficiently convert chemical energy into movement, and additionally are capable of performing complicated motion depending on environmental conditions. In this sense, biohybrid microswimmer systems can be described as the combination of different functional components: cargo and carrier. The cargo is an element of interest to be moved (and possibly released) in a customized way. The carrier is the component responsible for the movement of the biohybrid, transporting the desired cargo, which is linked to its surface. The great majority of these systems rely on biological motile propulsion for the transportation of synthetic cargo for targeted drug delivery/ There are also examples of the opposite case: artificial microswimmers with biological cargo systems. Over the past decade, biohybrid microrobots, in which living mobile microorganisms are physically integrated with untethered artificial structures, have gained growing interest to enable the active locomotion and cargo delivery to a target destination. In addition to the motility, the intrinsic capabilities of sensing and eliciting an appropriate response to artificial and environmental changes make cell-based biohybrid microrobots appealing for transportation of cargo to the inaccessible cavities of the human body for local active delivery of diagnostic and therapeutic agents. Active locomotion, targeting and steering of concentrated therape
Calais (Reuters product)
Calais is a service created by Thomson Reuters that automatically extracts semantic information from web pages in a format that can be used on the semantic web. Calais was launched in January 2008, and is free to use. The technology is now available via the website of Refinitiv, a provider of financial market data and infrastructure founded in 2018, that is a subsidiary of London Stock Exchange Group. The Calais Web service reads unstructured text and returns Resource Description Framework formatted results identifying entities, facts and events within the text. The service appears to be based on technology acquired when Reuters purchased ClearForest in 2007. The technology has also been used to automatically tag blog articles, and organize museum collections. Calais uses natural language processing technologies delivered via a web service interface.
Cloud Data Management Interface
ISO/IEC 17826 Information technology — Cloud Data Management Interface (CDMI) Version 2.0.0 is an international standard that specifies a protocol for self-provisioning, administering and managing access to data stored in cloud storage, object storage, storage area network and network attached storage systems. The CDMI standard is developed and maintained by the Storage Networking Industry Association, who makes a publicly accessible version of the specification available. CDMI defines new resource representations to enable standardized management of any URI-accessible data, and defines RESTful HTTP operations using these representations to discover the capabilities of the storage system, discover stored data, access and update management metadata, specify data storage protocols (such as iSCSI and NFS) through which the stored data is accessed, and provide cross-system and cross-cloud import and export in order to enable data portability. Management functions enabled by CDMI include managing data ownership, identity mapping, access controls, user-specified metadata, and to declaratively specify desired data protection, data retention, constraints on geographic placement, desired quality of service, data versioning and security requirements. CDMI also defines utility services to facilitate data management, such the ability to query data matching specific criteria, and includes extensions to perform bulk updates using CDMI Jobs. == Capabilities == Compliant implementations must provide access to a set of configuration parameters known as capabilities. These are either boolean values that represent whether or not a system supports things such as queues, export via other protocols, path-based storage and so on, or numeric values expressing system limits, such as how much metadata may be placed on an object. As a minimal compliant implementation can be quite small, with few features, clients need to check the cloud storage system for a capability before attempting to use the functionality it represents. Resource allocation assignments limited to the data management interface protocols must possess access bypass capabilities which extend beyond the layered framework. This integral function is vital to the prevention of transport layer session hijacking by unauthorized entities which may circumvent standard interfacing security parameters. == Containers == A CDMI client may access objects, including containers, by either name or object id (OID), assuming the CDMI server supports both methods. When storing objects by name, it is natural to use nested named containers; the resulting structure corresponds exactly to a traditional filesystem directory structure. == Objects == Objects are similar to files in a traditional file system, but are enhanced with an increased amount and capacity for metadata. As with containers, they may be accessed by either name or OID. When accessed by name, clients use URLs that contain the full pathname of objects to create, read, update and delete them. When accessed by OID, the URL specifies an OID string in the cdmi-objectid container; this container presents a flat name space conformant with standard object storage system semantics. Subject to system limits, objects may be of any size or type and have arbitrary user-supplied metadata attached to them. Systems that support query allow arbitrary queries to be run against the metadata. == Domains, Users and Groups == CDMI supports the concept of a domain, similar in concept to a domain in the Windows Active Directory model. Users and groups created in a domain share a common administrative database and are known to each other on a "first name" basis, i.e. without reference to any other domain or system. Domains also function as containers for usage and billing summary data. == Access Control == CDMI exactly follows the ACL and ACE model used for file authorization operations by NFSv4. This makes it also compatible with Microsoft Windows systems. == Metadata == CDMI draws much of its metadata model from the XAM specification. Objects and containers have "storage system metadata", "data system metadata" and arbitrary user specified metadata, in addition to the metadata maintained by an ordinary filesystem (atime etc.). == Queries == CDMI specifies a way for systems to support arbitrary queries against CDMI containers, with a rich set of comparison operators, including support for regular expressions. == Queues == CDMI supports the concept of persistent FIFO (first-in, first-out) queues. These are useful for job scheduling, order processing and other tasks in which lists of things must be processed in order. == Compliance == Both retention intervals and retention holds are supported by CDMI. A retention interval consists of a start time and a retention period. During this time interval, objects are preserved as immutable and may not be deleted. A retention hold is usually placed on an object because of judicial action and has the same effect: objects may not be changed nor deleted until all holds placed on them are removed. == Billing == Summary information suitable for billing clients for on-demand services can be obtained by authorized users from systems that support it. == Serialization == Serialization of objects and containers allows export of all data and metadata on a system and importation of that data into another cloud system. == Foreign protocols == CDMI supports export of containers as NFS or CIFS shares. Clients that mount these shares see the container hierarchy as an ordinary filesystem directory hierarchy, and the objects in the containers as normal files. Metadata outside of ordinary filesystem metadata may or may not be exposed. Provisioning of iSCSI LUNs is also supported. == Client SDKs == CDMI Reference Implementation Droplet libcdmi-java libcdmi-python .NET SDK
Server-Gated Cryptography
Server-Gated Cryptography (SGC), also known as International Step-Up by Netscape, is a defunct mechanism that was used to step up from 40-bit or 56-bit to 128-bit cipher suites with SSL. It was created in response to United States federal legislation on the export of strong cryptography in the 1990s. The legislation had limited encryption to weak algorithms and shorter key lengths in software exported outside of the United States of America. When the legislation added an exception for financial transactions, SGC was created as an extension to SSL with the certificates being restricted to financial organisations. In 1999, this list was expanded to include online merchants, healthcare organizations, and insurance companies. This legislation changed in January 2000, resulting in vendors no longer shipping export-grade browsers and SGC certificates becoming available without restriction. Internet Explorer supported SGC starting with patched versions of Internet Explorer 3. SGC became obsolete when Internet Explorer 5.01 SP1 and Internet Explorer 5.5 started supporting strong encryption without the need for a separate high encryption pack (except on Windows 2000, which needs its own high encryption pack that was included in Service Pack 2 and later). "Export-grade" browsers are unusable on the modern Web due to many servers disabling export cipher suites. Additionally, these browsers are incapable of using SHA-2 family signature hash algorithms like SHA-256. Certification authorities are trying to phase out the new issuance of certificates with the older SHA-1 signature hash algorithm. The continuing use of SGC facilitates the use of obsolete, insecure Web browsers with HTTPS. However, while certificates that use the SHA-1 signature hash algorithm remain available, some certificate authorities continue to issue SGC certificates (often charging a premium for them) although they are obsolete. The reason certificate authorities can charge a premium for SGC certificates is that browsers only allowed a limited number of roots to support SGC. When an SSL handshake takes place, the software (e.g. a web browser) would list the ciphers that it supports. Although the weaker exported browsers would only include weaker ciphers in its initial SSL handshake, the browser also contained stronger cryptography algorithms. There are two protocols involved to activate them. Netscape Communicator 4 used International Step-Up, which used the now obsolete insecure renegotiation to change to a stronger cipher suite. Microsoft used SGC, which sends a new Client Hello message listing the stronger cipher suites on the same connection after the certificate is determined to be SGC capable, and also supported Netscape Step-Up for compatibility (though this support in the NT 4.0 SP6 and IE 5.01 version had a bug where changing MAC algorithms during Step-Up did not work properly).
Data refuge
Data Refuge is a public and collaborative project designed to address concerns about federal climate and environmental data that is in danger of being lost. In particular, the initiative addresses five main concerns: What are the best ways to safeguard data? How do federal agencies play a crucial role in collecting, managing, and distributing data? How do government priorities impact data's accessibility? Which projects and research fields depend on federal data? Which data sets are of value to research and local communities, and why? Data Refuge began as a grassroots organization in opposition to government data on climate change and the environment not being archived systemically. Data Refuge's main goal is to collect and allocate data in multiple safe locations to create a sustainable way of archiving old and new data. Data Refuge was initiated in 2016 to protect federal climate and environmental data that is vulnerable under an administration that denies climate change. The system aims to make public research-quality copies of federal climate and environmental data. Data Refuge is supported by the National Geographic Foundation, private donors, Libraries+ Network, Preserving Electronic Governance Initiative (PEGI), the Union of Concerned Scientists (USC), and the Penn Program in Environmental Humanities (PPEH). == Types of data == Data Refuge collects public federal data on the climate and environment in the form of satellite imagery, PDFs, and stories. The data are stored in multiple trusted locations as they are less vulnerable if in only one location, and to ensure accessibility for researchers. Through the Data Rescue events, Data Refuge has accumulated 4 terabytes of data, 30,000 URLs, and 800 participants. === Storytelling === Data Refuge collects stories on vulnerable federal climate and environmental data through: surveys, oral history, photo essays, maps, video shorts, and animations. The stories are archived in a public bank that showcase how federal environmental data support health and safety in communities. Data Stories are collected at Data Rescue events, which are partnered with universities, city and town halls, and advocacy groups. Data stories are collected and used to emphasize the importance of Data Refuge, in how the data on climate change and the environment are being used by people in the United States and across the world for meaningful practices.
Semantic analytics
Semantic analytics, also termed semantic relatedness, is the use of ontologies to analyze content in web resources. This field of research combines text analytics and Semantic Web technologies like RDF. Semantic analytics measures the relatedness of different ontological concepts. Some academic research groups that have active project in this area include Kno.e.sis Center at Wright State University among others. == History == An important milestone in the beginning of semantic analytics occurred in 1996, although the historical progression of these algorithms is largely subjective. In his seminal study publication, Philip Resnik established that computers have the capacity to emulate human judgement. Spanning the publications of multiple journals, improvements to the accuracy of general semantic analytic computations all claimed to revolutionize the field. However, the lack of a standard terminology throughout the late 1990s was the cause of much miscommunication. This prompted Budanitsky & Hirst to standardize the subject in 2006 with a summary that also set a framework for modern spelling and grammar analysis. In the early days of semantic analytics, obtaining a large enough reliable knowledge bases was difficult. In 2006, Strube & Ponzetto demonstrated that Wikipedia could be used in semantic analytic calculations. The usage of a large knowledge base like Wikipedia allows for an increase in both the accuracy and applicability of semantic analytics. == Methods == Given the subjective nature of the field, different methods used in semantic analytics depend on the domain of application. No singular methods is considered correct, however one of the most generally effective and applicable method is explicit semantic analysis (ESA). ESA was developed by Evgeniy Gabrilovich and Shaul Markovitch in the late 2000s. It uses machine learning techniques to create a semantic interpreter, which extracts text fragments from articles into a sorted list. The fragments are sorted by how related they are to the surrounding text. Latent semantic analysis (LSA) is another common method that does not use ontologies, only considering the text in the input space. == Applications == Entity linking Ontology building / knowledge base population Search and query tasks Natural language processing Spoken dialog systems (e.g., Amazon Alexa, Google Assistant, Microsoft's Cortana) Artificial intelligence Knowledge management The application of semantic analysis methods generally streamlines organizational processes of any knowledge management system. Academic libraries often use a domain-specific application to create a more efficient organizational system. By classifying scientific publications using semantics and Wikipedia, researchers are helping people find resources faster. Search engines like Semantic Scholar provide organized access to millions of articles.
Unknown key-share attack
As defined by Blake-Wilson & Menezes (1999), an unknown key-share (UKS) attack on an authenticated key agreement (AK) or authenticated key agreement with key confirmation (AKC) protocol is an attack whereby an entity A {\displaystyle A} ends up believing she shares a key with B {\displaystyle B} , and although this is in fact the case, B {\displaystyle B} mistakenly believes the key is instead shared with an entity E ≠ A {\displaystyle E\neq A} . In other words, in a UKS, an opponent, say Eve, coerces honest parties Alice and Bob into establishing a secret key where at least one of Alice and Bob does not know that the secret key is shared with the other. For example, Eve may coerce Bob into believing he shares the key with Eve, while he actually shares the key with Alice. The “key share” with Alice is thus unknown to Bob.