Tute Genomics was an American genomics startup that provided a cloud-based web application for rapid and accurate annotation of human genomic data. It was built on the expertise of ANNOVAR. Tute Genomics assisted researchers in identifying disease genes and biomarkers, and assisted clinicians/labs in performing genetic diagnosis. Based in Provo, Utah, Tute was co-founded by Dr. Kai Wang, an assistant professor at the University of Southern California (USC); and Dr. Reid J. Robison, a board-certified psychiatrist with fellowship training in both neurodevelopmental genetics and bioinformatics. Tute Genomics was acquired by PierianDX in 2016. == History == The word "tute" means "personal" in the Na’vi language created for the 2009 film Avatar by Paul Frommer, a linguist and communications professor at the USC Marshall School of Business. === Timeline === 2013 Tute Genomics launched in 2013 and entered the accelerator, BoomStartup. By "demo day" of BoomStartup, Tute had raised their seed round of funding and expanded the round to include angel investors from SLC Angels, Park City Angels, Life Science Angels. Tute was the tenth ever online syndicate for AngelList and in all raised a seed round of $1.5 million. 2014 In March 2014, the company announced that Affiliated Genetics, a Utah-based CLIA-certified laboratory, selected Tute Genomics for its next-generation sequencing (NGS) analytics pipeline. In May 2014, the company announced joining the Global Alliance for Genomics and Health. In June 2014, Advanced Biological Laboratories (ABL), S.A., announced a licensing and collaboration agreement with Tute Genomics and the commercial launch of OncoChek for managing and analysing genomics data in the field of oncology. In July 2014, the company announced an agreement with Lineagen, Inc., to provide next-generation sequencing analytics for Lineagen’s NextStepDx Plus assay. Also, Brigham Young University selected the Tute Genomics genome annotation and discovery platform for analysis and interpretation of 1,000 exomes and genomes. In November 2014, the company announced addition of the Tute platform to Illumina’s BaseSpace. The company announced a Series A1 funding round of $2.3 million in December 2014. The round was led by UK-based Eurovestech. Peak Ventures and a number of angel investors also participated in this round. 2015 Tute recruits David Mittelman, founder of Arpeggi, Inc. and former CSO at FamilyTreeDNA, to Tute Genomics as Chief Scientific Officer. Tute acquires Knome and integrates the KnoSys platform into its software product. 2016 Reid Robison, Tute CEO, launches a Kickstarter campaign to sell Tute interpreted whole genome and whole exome sequencing directly to consumers. The campaign was suspended within the same month after receiving a letter from the United States Food and Drug Administration. Tute is acquired by PierianDX.
Thermal attack
A thermal attack (aka thermal imaging attack) is an approach that exploits heat traces to uncover the entered credentials. These attacks rely on the phenomenon of heat transfer from one object to another. During authentication, heat transfers from the users' hands to the surface they are interacting with, leaving heat traces behind that can be analyzed using thermal cameras that operate in the far-infrared spectrum. These traces can be recovered and used to reconstruct the passwords. In some cases, the attack can be successful even 30 seconds after the user has authenticated. Thermal attacks can be performed after the victim had authenticated, alleviating the need for in-situ observation attacks (e.g., shoulder surfing attacks) that can be affected by hand occlusions. While smudge attacks can reveal the order of entries of graphical passwords, such as the Android Lock Patterns, thermal attacks can reveal the order of entries even in the case of PINs or alphanumeric passwords. The reason thermal attacks leak information about the order of entry is because keys and buttons that the user touches first lose heat over time, while recently touched ones maintain the heat signature for a longer time. This results in distinguishable heat patterns that can tell the attacker which entry was entered first. Thermal attacks were shown to be effective against plastic keypads, such as the ones used to enter credit card's PINs in supermarkets and restaurants, and on handheld mobile devices such as smartphones and tablets. In their paper published at the Conference on Human Factors in Computing Systems (CHI 2017), Abdelrahman et al. showed that the attack is feasible on today's smartphones. They also proposed some ways to mitigate the attack, such as swiping randomly on the screen to distort the heat traces, or forcing maximum CPU usage for a few seconds. Thermal attacks can also infer passwords from heat traces on keyboards. Researchers at the University of Glasgow showed that attackers who use AI methods can be more effective in performing thermal attacks. Their study presents a new tool called ThermoSecure and evaluates it in two user studies. The results show that ThermoSecure can successfully attack passwords with an average accuracy of 92% to 55%, depending on the length of the password. The effectiveness of thermal attacks also depends on typing behavior and the material of the keycaps. ABS keycaps, which retain heat traces longer, are more vulnerable to thermal attacks. The study also discusses ways to protect against thermal attacks and presents seven potential mitigation approaches. Dr Khamis, who led the development of the technology with Norah Alotaibi and John Williamson, said with thermal imaging cameras more affordable than ever and machine learning becoming more accessible, it was "very likely that people around the world are developing systems along similar lines to ThermoSecure in order to steal passwords". == Thermal Attack Mitigation == === Simple and Practical Measures === One basic and effective way to mitigate thermal attacks is to deliberately create heat noise over the input interface, such as a keypad or keyboard, after entering a password. For instance, placing one's palm over the entire interface for a few seconds after use can obscure the thermal pattern left by the fingers, making it much more difficult for an unauthorized user to interpret the heat traces. === Range of Proposed Strategies === In addition to simple methods, researchers have developed a spectrum of mitigation strategies to counter thermal attacks. These strategies encompass 15 different approaches including: Use of Biometrics: Replacing traditional pin codes or passwords with biometric authentication, such as fingerprint recognition or facial recognition, eliminates the issue of residual heat on keypads. Heating the Interface: Implementing technology to slightly warm up the keypad can effectively neutralize the heat traces left by fingers, preventing thermal cameras from capturing the pattern. Randomizing Key Layouts: Employing dynamic key layouts that change positions every time the interface is used, making it impossible to correlate heat patterns with static input positions. === Technological Intervention on Thermal Cameras === Another avenue for mitigation is to address the issue at the source by modifying thermal cameras. Proposals have been made to develop thermal cameras that can automatically detect vulnerable interfaces such as keyboards or keypads. When these interfaces are detected within the camera's field of view, the camera would be programmed to prevent the user from recording images of them. This solution, however, would require widespread adoption by thermal camera manufacturers. Additionally, the approach is particularly viable for thermal cameras connected to a computing device, such as a smartphone, which can process the images in real time. Many affordable thermal cameras are standalone and do not have connectivity or processing capabilities. However, thermal cameras designed for connection to mobile devices can utilize the smartphone's processing power, making this mitigation approach feasible for such devices.
Eurotra
Eurotra was a machine translation project established and funded by the European Commission from 1978 until 1992. == History == In 1976, the European Commission started using the commercially developed machine translation system SYSTRAN with a plan to make it work for further languages than originally developed for (Russian-English and English-French), which however turned out to be difficult. This and the potential in existing systems within European research center, led to the decision in 1978 to start the project Eurotra, first through a preparatory Eurotra Coordination Group. Four years later, the European Commission and coordination group gained the approval of the European Parliament. The goal of the project as to create machine translation system for the official languages of the European Community, which at the time were Danish, Dutch, German, English, French, Italian, later including Greek, Spanish and Portuguese. However, as time passed, expectations became tempered; "Fully Automatic High Quality Translation" was not a reasonably attainable goal. The true character of Eurotra was eventually acknowledged to be in fact pre-competitive research rather than prototype development. The project was motivated by one of the founding principles of the EU: that all citizens had the right to read any and all proceedings of the Commission in their own language. As more countries joined, this produced a combinatorial explosion in the number of language pairs involved, and the need to translate every paper, speech and even set of meeting minutes produced by the EU into the other eight languages meant that translation rapidly became the overwhelming component in the administrative budget. To solve this problem Eurotra was devised. The project was unusual in that rather than consisting of a single research team, it had member groups distributed around the member countries, organised along language rather than national lines (for example, groups in Leuven and Utrecht worked closely together), and the secretariat was based at the European Commission in Luxembourg. The actual design of the project was unusual as MT projects go. Older systems, such as SYSTRAN, were heavily dictionary-based, with minor support for rearranging word order. More recent systems have often worked on a probabilistic approach, based on parallel corpora. Eurotra addressed the constituent structure of the text to be translated, going through first a syntactic parse followed by a second parse to produce a dependency structure followed by a final parse with a third grammar to produce what was referred to internally as Intermediate Representation (IR). Since all three modules were implemented as Prolog programs, it would then in principle be possible to put this structure backwards through the corresponding modules for another language to produce a translated text in any of the other languages. However, in practice this was not in fact how language pairs were implemented. The first "live" translation occupied a 4Mb Microvax running Ultrix and C-Prolog for a complete weekend some time in early 1987. The sentence, translated from English into Danish, was "Japan makes computers". The main problem faced by the system was the generation of so-called "Parse Forests" - often a large number of different grammar rules could be applied to any particular phrase, producing hundreds, even thousands of (often identical) parse trees. This used up huge quantities of computer store, slowing the whole process down unnecessarily. While Eurotra never delivered a "working" MT system, the project made a far-reaching long-term impact on the nascent language industries in European member states, in particular among the southern countries of Greece, Italy, Spain, and Portugal. There is at least one commercial MT system (developed by an academic/commercial consortium in Denmark) derived from Eurotra technology.
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Legendre moment
In mathematics, Legendre moments are a type of image moment and are achieved by using the Legendre polynomial. Legendre moments are used in areas of image processing including: pattern and object recognition, image indexing, line fitting, feature extraction, edge detection, and texture analysis. Legendre moments have been studied as a means to reduce image moment calculation complexity by limiting the amount of information redundancy through approximation. == Legendre moments == Source: With order of m + n, and object intensity function f(x,y): L m n = ( 2 m + 1 ) ( 2 n + 1 ) 4 ∫ − 1 1 ∫ − 1 1 P m ( x ) P n ( y ) f ( x , y ) d x d y {\displaystyle L_{mn}={\frac {(2m+1)(2n+1)}{4}}\int \limits _{-1}^{1}\int \limits _{-1}^{1}P_{m}(x)P_{n}(y)f(x,y)\,dx\,dy} where m,n = 1, 2, 3, ...∞ with the nth-order Legendre polynomials being: P n ( x ) = ∑ k = 0 n a k , n x k = ( − 1 ) n 2 n n ! ( d d x ) [ ( 1 − x 2 ) n ] {\displaystyle P_{n}(x)=\sum _{k=0}^{n}a_{k,n}x^{k}={\frac {(-1)^{n}}{2^{n}n!}}\left({\frac {d}{dx}}\right)[(1-x^{2})^{n}]} which can also be written: P n ( x ) = ∑ k = 0 D ( n ) ( − 1 ) k ( 2 n − 2 k ) ! 2 n k ! ( n − k ) ! ( n − 2 k ) ! x n − 2 k = ( 2 n ) ! 2 n ( n ! ) 2 x n − ( 2 n − 2 ) ! 2 n 1 ! ( n − 1 ) ! ( n − 2 ) ! x n − 2 + ⋯ {\displaystyle {\begin{aligned}P_{n}(x)&=\sum _{k=0}^{D(n)}(-1)^{k}{\frac {(2n-2k)!}{2^{n}k!(n-k)!(n-2k)!}}x^{n-2k}\\[5pt]&={\frac {(2n)!}{2^{n}(n!)^{2}}}x^{n}-{\frac {(2n-2)!}{2^{n}1!(n-1)!(n-2)!}}x^{n-2}+\cdots \end{aligned}}} where D(n) = floor(n/2). The set of Legendre polynomials {Pn(x)} form an orthogonal set on the interval [−1,1]: ∫ − 1 1 P n ( x ) P m ( x ) d x = 2 2 n + 1 δ n m {\displaystyle \int _{-1}^{1}P_{n}(x)P_{m}(x)\,dx={\frac {2}{2n+1}}\delta _{nm}} A recurrence relation can be used to compute the Legendre polynomial: ( n + 1 ) P n + 1 ( x ) − ( 2 n + 1 ) x P n ( x ) + n P n − 1 ( x ) = 0 {\displaystyle (n+1)P_{n+1}(x)-(2n+1)xP_{n}(x)+nP_{n-1}(x)=0} f(x,y) can be written as an infinite series expansion in terms of Legendre polynomials [−1 ≤ x,y ≤ 1.]: f ( x , y ) = ∑ m = 0 ∞ ∑ n = 0 ∞ λ m n P m ( x ) P n ( y ) {\displaystyle f(x,y)=\sum _{m=0}^{\infty }\sum _{n=0}^{\infty }\lambda _{mn}P_{m}(x)P_{n}(y)}
Geoffrey J. Gordon
Geoffrey J. Gordon is a professor at the Machine Learning Department at Carnegie Mellon University in Pittsburgh and director of research at the Microsoft Montréal lab. He is known for his research in statistical relational learning (a subdiscipline of artificial intelligence and machine learning) and on anytime dynamic variants of the A search algorithm. His research interests include multi-agent planning, reinforcement learning, decision-theoretic planning, statistical models of difficult data (e.g. maps, video, text), computational learning theory, and game theory. Gordon received a B.A. in computer science from Cornell University in 1991, and a PhD at Carnegie Mellon in 1999.