Super-resolution optical fluctuation imaging

Super-resolution optical fluctuation imaging (SOFI) is a post-processing method for the calculation of super-resolved images from recorded image time series that is based on the temporal correlations of independently fluctuating fluorescent emitters. SOFI has been developed for super-resolution of biological specimen that are labelled with independently fluctuating fluorescent emitters (organic dyes, fluorescent proteins). In comparison to other super-resolution microscopy techniques such as STORM or PALM that rely on single-molecule localization and hence only allow one active molecule per diffraction-limited area (DLA) and timepoint, SOFI does not necessitate a controlled photoswitching and/ or photoactivation as well as long imaging times. Nevertheless, it still requires fluorophores that are cycling through two distinguishable states, either real on-/off-states or states with different fluorescence intensities. In mathematical terms SOFI-imaging relies on the calculation of cumulants, for what two distinguishable ways exist. For one thing an image can be calculated via auto-cumulants that by definition only rely on the information of each pixel itself, and for another thing an improved method utilizes the information of different pixels via the calculation of cross-cumulants. Both methods can increase the final image resolution significantly although the cumulant calculation has its limitations. Actually SOFI is able to increase the resolution in all three dimensions. == Principle == Likewise to other super-resolution methods SOFI is based on recording an image time series on a CCD- or CMOS camera. In contrary to other methods the recorded time series can be substantially shorter, since a precise localization of emitters is not required and therefore a larger quantity of activated fluorophores per diffraction-limited area is allowed. The pixel values of a SOFI-image of the n-th order are calculated from the values of the pixel time series in the form of a n-th order cumulant, whereas the final value assigned to a pixel can be imagined as the integral over a correlation function. The finally assigned pixel value intensities are a measure of the brightness and correlation of the fluorescence signal. Mathematically, the n-th order cumulant is related to the n-th order correlation function, but exhibits some advantages concerning the resulting resolution of the image. Since in SOFI several emitters per DLA are allowed, the photon count at each pixel results from the superposition of the signals of all activated nearby emitters. The cumulant calculation now filters the signal and leaves only highly correlated fluctuations. This provides a contrast enhancement and therefore a background reduction for good measure. As it is implied in the figure on the left the fluorescence source distribution: ∑ k = 1 N δ ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) {\displaystyle \sum _{k=1}^{N}\delta ({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t)} is convolved with the system's point spread function (PSF) U(r). Hence the fluorescence signal at time t and position r → {\displaystyle {\vec {r}}} is given by F ( r → , t ) = ∑ k = 1 N U ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) . {\displaystyle F({\vec {r}},t)=\sum _{k=1}^{N}U({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t).} Within the above equations N is the amount of emitters, located at the positions r → k {\displaystyle {\vec {r}}_{k}} with a time-dependent molecular brightness ε k ⋅ s k {\displaystyle \varepsilon _{k}\cdot s_{k}} where ε k {\displaystyle \varepsilon _{k}} is a variable for the constant molecular brightness and s k ( t ) {\displaystyle s_{k}(t)} is a time-dependent fluctuation function. The molecular brightness is just the average fluorescence count-rate divided by the number of molecules within a specific region. For simplification it has to be assumed that the sample is in a stationary equilibrium and therefore the fluorescence signal can be expressed as a zero-mean fluctuation: δ F ( r → , t ) = F ( r → , t ) − ⟨ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=F({\vec {r}},t)-\langle F({\vec {r}},t)\rangle _{t}} where ⟨ ⋯ ⟩ t {\displaystyle \langle \cdots \rangle _{t}} denotes time-averaging. The auto-correlation here e.g. the second-order can then be described deductively as follows for a certain time-lag τ {\displaystyle \tau } : δ F ( r → , t ) = ⟨ δ F ( r → , t + τ ) ⋅ δ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=\langle \delta F({\vec {r}},t+\tau )\cdot \delta F({\vec {r}},t)\rangle _{t}} From these equations it follows that the PSF of the optical system has to be taken to the power of the order of the correlation. Thus in a second-order correlation the PSF would be reduced along all dimensions by a factor of 2 {\displaystyle {\sqrt {2}}} . As a result, the resolution of the SOFI-images increases according to this factor. === Cumulants versus correlations === Using only the simple correlation function for a reassignment of pixel values, would ascribe to the independency of fluctuations of the emitters in time in a way that no cross-correlation terms would contribute to the new pixel value. Calculations of higher-order correlation functions would suffer from lower-order correlations for what reason it is superior to calculate cumulants, since all lower-order correlation terms vanish. == Cumulant-calculation == === Auto-cumulants === For computational reasons it is convenient to set all time-lags in higher-order cumulants to zero so that a general expression for the n-th order auto-cumulant can be found: A C n ( r → , τ 1 … n − 1 = 0 ) = ∑ k = 1 N U n ( r → − r → k ) ε k n w k ( 0 ) {\displaystyle AC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\sum _{k=1}^{N}U^{n}({\vec {r}}-{\vec {r}}_{k})\varepsilon _{k}^{n}w_{k}(0)} w k {\displaystyle w_{k}} is a specific correlation based weighting function influenced by the order of the cumulant and mainly depending on the fluctuation properties of the emitters. Albeit there is no fundamental limitation in calculating very high orders of cumulants and thereby shrinking the FWHM of the PSF there are practical limitations according to the weighting of the values assigned to the final image. Emitters with a higher molecular brightness will show a strong increase in terms of the pixel cumulant value assigned at higher-orders as well as this performance can be expected from a diverse appearance of fluctuations of different emitters. A wide intensity range of the resulting image can therefore be expected and as a result dim emitters can get masked by bright emitters in higher-order images:. The calculation of auto-cumulants can be realized in a very attractive way in a mathematical sense. The n-th order cumulant can be calculated with a basic recursion from moments K n ( r → ) = μ n ( r → ) − ∑ i = 1 n − 1 ( n − 1 i ) K n − i ( r → ) μ i ( r → ) {\displaystyle K_{n}({\vec {r}})=\mu _{n}({\vec {r}})-\sum _{i=1}^{n-1}{\begin{pmatrix}n-1\\i\end{pmatrix}}K_{n-i}({\vec {r}})\mu _{i}({\vec {r}})} where K is a cumulant of the index's order, likewise μ {\displaystyle \mu } represents the moments. The term within the brackets indicates a binomial coefficient. This way of computation is straightforward in comparison with calculating cumulants with standard formulas. It allows for the calculation of cumulants with only little time of computing and is, as it is well implemented, even suitable for the calculation of high-order cumulants on large images. === Cross-cumulants === In a more advanced approach cross-cumulants are calculated by taking the information of several pixels into account. Cross-cumulants can be described as follows: C C n ( r → , τ 1 … n − 1 = 0 ) = ∏ j < l n U ( r → j − r → l n ) ⋅ ∑ i = 1 N U n ( r → i − ∑ k n r → k n ) ε i n w i ( 0 ) {\displaystyle CC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\prod _{j

Foodsi

Foodsi is a Polish mobile application that connects customers with restaurants, convenience stores, bakeries and cafes that have a surplus of food, allowing its users to buy the surplus at a reduced price. The service launched in 2019 in Warsaw and has expanded to other major cities in Poland. In 2023, a new feature was introduced in the app, allowing users to buy packages not only with self-pickup but also with delivery. The products range has also been expanded to include unsold magazines, cosmetics or plants. == History == The company was created in 2019 in Poland by Mateusz Kowalczyk and Jakub Fryszczyn. During studies in their home country and abroad, when they made a living working in restaurants and bakeries, they recognized the problem and the scale of food waste. They launched the application by themselves, having previously raised PLN 100,000 on their own for the purpose. Initially, Foodsi was an Android-only app, but over time, an IOS version was developed. In 2022, the startup raised PLN 6 million in a seed round from VC companies including CofounderZone and Status Starter, as well as private investors such as founders of Pyszne.pl. As of December 2023, it claimed more than 5000 businesses, serving over 1,5 million users, have saved nearly 3 million bags of food. == Purpose == Foodsi aims to significantly reduce food waste, which contributes to the Sustainable Development Goals. The application bridges the gap between the customers who are looking for shopping deals and the companies that want to reduce surplus products but are unable to sell them at a normal price. This allows the customers to buy unsold products for as little as 30% of the normal price. The company claims that every 4 out of 5 packages are sold on average. As of 2019 Foodsi employed more than 30 people. By 2024 it was more than 50. For now, Foodsi operates in major Polish cities such as Warsaw, Kraków, Trójmiasto, Wrocław, Poznań etc. However, in the upcoming years, Foodsi plans to expand to other countries. == Use == To start selling surplus, a company must leave Foodsi its contact information to register in the system. Registration in the app is completely free of charge. Then, companies offer available packages anticipating what won’t be sold and post them in the app along with the price so that users can buy them and pick them up. Companies can put their packages in the app at any time during the day. Users can pick up packages from bakeries, grocery stores, restaurants, but also florists and beauty stores. Foodsi charges a small commission on each package from the cooperating companies. If a user wants to start ordering packages from Foodsi, he or she needs to install the app on their mobile phone (Android or IOS) and register an account. The app displays a list of restaurants and other venues available in a specific region set by the user's location. Customers can see the price, address, distance and time range for package pickup. Packages are usually in the form of so-called 'surprise-packages', meaning that customers do not know specifically what kind of food/product will be inside. Some restaurants offer a choice of different package sizes. Prices are up to 70% lower than those of the original products. Customers have to show up at the restaurant to pick up the package using their phone at a time specified in the app. == Awards == Auler All-Stars 2025 - 3rd place Deloitte Technology Fast 50 - 2025 Central Europe Executive Club - Innowacja Roku: Żywność i Rolnictwo - Wyróżnienie (2025) Stena Circular Economy Award - Lider Gospodarki Obiegu Zamkniętego (2025) - wyróżnienie w kategorii start-up wdrażający GOZ na rynku polskim 255th place in the international poll FoodTech 500 2025 Finalist for the EY Entrepreneur Of The Year™ 2025 Wpływowi 2024 - Laureat w kategorii “Zrównoważony rozwój” Supplier of the Year 2024 - XXII Food & Business Forum Supplier of the Year 2024 - VII Sweets & Coffee Forum Innovative Leader 2024 - Leader in Food / Food-Tech Category - Executive Summit “Orzeł Innowacji - Start-up z potencjałem Polska-Świat” (Rzeczpospolita, 2024) 102nd place in the international poll FoodTech 500 2024 Auler 2023 Startup of the Year 2023 according to money.pl Start(up) w zrównoważoną przyszłość Kongresu Kompas ESG 2023 Marka Godna Zaufania according to My Company Polska 2023 184th place in the international poll FoodTech 500 2023 In 2023, Foodsi co-founder Mateusz Kowalczyk was recognized by Forbes magazine and included in its "30 before 30" list.

ITools Resourceome

iTools is a distributed infrastructure for managing, discovery, comparison and integration of computational biology resources. iTools employs Biositemap technology to retrieve and service meta-data about diverse bioinformatics data services, tools, and web-services. iTools is developed by the National Centers for Biomedical Computing as part of the NIH Road Map Initiative.

Framework Convention on Artificial Intelligence

The Framework Convention on Artificial Intelligence and Human Rights, Democracy and the Rule of Law (also called Framework Convention on Artificial Intelligence or AI convention) is an international treaty on artificial intelligence. It was adopted under the auspices of the Council of Europe (CoE) and signed on 5 September 2024. The treaty aims to ensure that the development and use of AI technologies align with fundamental human rights, democratic values, and the rule of law, addressing risks such as misinformation, algorithmic discrimination, and threats to public institutions. More than 50 countries, including the EU member states, have endorsed the Framework Convention on Artificial Intelligence. == Background == The development of the Framework Convention on AI emerged in response to growing concerns over the ethical, legal, and societal impacts of artificial intelligence. The Council of Europe, which has historically played a key role in setting human rights standards across Europe, initiated discussions on AI governance in 2020, leading to the drafting of a binding legal framework. The process of creating the Framework Convention began in 2019 with the ad hoc Committee on Artificial Intelligence (CAHAI) assessing the feasibility of the instrument. In 2022, the Committee on Artificial Intelligence (CAI) took over the process, drafting and negotiating the text of the Convention. The treaty is designed to complement existing international human rights instruments, including the European Convention on Human Rights and the Convention for the Protection of Individuals with regard to Automatic Processing of Personal Data. == Structure and content == The Convention establishes fundamental principles for AI governance, including transparency, accountability, non-discrimination, and human rights protection through eight chapters and 26 articles. Adopted in 2024, this landmark treaty addresses AI governance through seven core principles and detailed implementation mechanisms. It mandates risk and impact assessments to mitigate potential harms and provides safeguards such as the right to challenge AI-driven decisions. It applies to public authorities and private entities acting on their behalf but excludes national security and defense activities. Implementation is overseen by a Conference of the Parties, ensuring compliance and international cooperation. Activities within the AI system lifecycle must adhere to seven fundamental principles, ensuring compliance with human rights, democracy, and the rule of law. The treaty also establishes remedies, procedural rights and safeguards, and risk and impact management requirements to promote accountability, transparency, and responsible AI development. The treaty consists of five chapters. Chapter I contains general provisions. Chapter II states the general obligation to protect human rights and the integrity of democratic processes and respect of the rule of law. The main principles and rights are contained in Chapter III, which consists of Articles 6 to 13. Chapter IV (Articles 14 to 15) sets up the legal remedies. Chapter V states the risk and impact management framework. Chapter VI facilitates the implementation criteria of the treaty. Chapter VII sets the co-operation and oversight mechanisms. Chapter VIII contains various concluding clauses. Article 1 declares the objectives of the treaty, to ensure that activities within the lifecycle of artificial intelligence systems are fully consistent with human rights, democracy and the rule of law. == Entry into force == The treaty will enter into force on the first day of the month following the expiration of a period of three months after the date on which five ratification made by five countries, including three member states of the Council of Europe. == Competing approaches == While the CoE's AI Convention represents a multilateral effort to regulate AI through a human rights-based approach, alternative frameworks have also been proposed. One notable example is the Munich Draft for a Convention on AI, Data and Human Rights, an initiative led by legal scholars and policymakers in Germany. The Munich Draft advocates for stronger safeguards against AI-related risks, emphasizing stricter data protection measures, accountability for AI developers, and explicit prohibitions on high-risk AI applications, such as mass surveillance and autonomous lethal weapons. Unlike the CoE convention, which focuses on balancing innovation with regulation, the Munich Draft takes a more precautionary stance, calling for tighter controls over AI deployment in sensitive domains. Other competing international efforts include the OECD’s AI Principles, the GPAI (Global Partnership on AI), and the European Union's AI Act, each of which offers different regulatory strategies to govern AI at regional and global levels. == Signatories == Signatories include Andorra, Canada, the European Union, Georgia, Iceland, Israel, Japan, Liechtenstein, the Republic of Moldova, Montenegro, Norway, San Marino, Switzerland, Ukraine, the United Kingdom, the United States, and Uruguay. == Endorsement == The treaty was widely endorsed by leading AI policy experts, including Stuart J. Russell, Virginia Dignum, Emma Ruttkamp-Bloem, Pascal Pichonnaz, Maria Helen Murphy, Angella Ndaka, Hannes Werthner, Katja Langenbucher, Gry Hasselbalch, Ricardo Baeza-Yates, Kutoma Wakunuma, Gianclaudio Malgieri, Oreste Pollicino, Nagla Rizk, Giovanni Sartor, Lee Tiedrich, Ingrid Schneider, Eduardo Bertoni, Garry Kasparov, Merve Hikcok, and Marc Rotenberg. The treaty was also endorsed by notable political leaders, including Theodoros Roussopoulos, President of the Parliamentart Assembly in the Council of Europe, and Christopher Holmes, Member of the House of Lords of the United Kingdom, and by the International Bar Association (IBA), and personally by Almudena Arpón de Mendívil, President of the IBA. The Center for AI and Digital Policy (CAIDP) has been carrying out a campaign to promote endorsement of the treaty by urging various countries to sign and ratify the treaty. The CAIDP further urged the countries to make a clear and firm commitment to ensure the full inclusion of the private sector under the treaty’s provisions.

DARPA AlphaDogfight

The DARPA AlphaDogfight was a 2019–2020 DARPA program that pitted computers using F-16 flight simulators against one another. The computers were managed by eight teams of humans, who competed in a single-round elimination for the right to battle a skilled human dogfighter. Heron Systems corporation wrote a deep reinforcement learning software tool that bested the human pilot by a score of 5–0. The tournament program was managed by the Applied Physics Laboratory. The trials took place in October 2019 and January 2020 while the finals were held in August 2020. In 2024 a successor version of the program was tested with in the physical world with the X-62A.

Second-order co-occurrence pointwise mutual information

In computational linguistics, second-order co-occurrence pointwise mutual information (SOC-PMI) is a method used to measure semantic similarity, or how close in meaning two words are. The method does not require the two words to appear together in a text. Instead, it works by analyzing the "neighbor" words that typically appear alongside each of the two target words in a large body of text (corpus). If the two target words frequently share the same neighbors, they are considered semantically similar. For example, the words "cemetery" and "graveyard" may not appear in the same sentence often, but they both frequently appear near words like "buried," "dead," and "funeral." SOC-PMI uses this shared context to determine that they have a similar meaning. The method is called "second-order" because it doesn't look at the direct co-occurrence of the target words (which would be first-order), but at the co-occurrence of their neighbors (a second level of association). The strength of these associations is quantified using pointwise mutual information (PMI). == History == The method builds on earlier work like the PMI-IR algorithm, which used the AltaVista search engine to calculate word association probabilities. The key advantage of a second-order approach like SOC-PMI is its ability to measure similarity between words that do not co-occur often, or at all. The British National Corpus (BNC) has been used as a source for word frequencies and contexts for this method. == Methodology == The SOC-PMI algorithm measures the similarity between two words, w 1 {\displaystyle w_{1}} and w 2 {\displaystyle w_{2}} , in several steps. === Step 1: Score neighboring words with PMI === First, for each target word ( w 1 {\displaystyle w_{1}} and w 2 {\displaystyle w_{2}} ), the algorithm identifies its "neighbor" words within a certain text window (e.g., within 5 words to the left or right) across a large corpus. The strength of the association between a target word t i {\displaystyle t_{i}} and its neighbor w {\displaystyle w} is calculated using pointwise mutual information (PMI). A higher PMI value means the two words appear together more often than would be expected by chance. The PMI between a target word t i {\displaystyle t_{i}} and a neighbor word w {\displaystyle w} is calculated as: f pmi ( t i , w ) = log 2 ⁡ f b ( t i , w ) × m f t ( t i ) f t ( w ) {\displaystyle f^{\text{pmi}}(t_{i},w)=\log _{2}{\frac {f^{b}(t_{i},w)\times m}{f^{t}(t_{i})f^{t}(w)}}} where: f b ( t i , w ) {\displaystyle f^{b}(t_{i},w)} is the number of times t i {\displaystyle t_{i}} and w {\displaystyle w} appear together in the context window. f t ( t i ) {\displaystyle f^{t}(t_{i})} is the total number of times t i {\displaystyle t_{i}} appears in the corpus. f t ( w ) {\displaystyle f^{t}(w)} is the total number of times w {\displaystyle w} appears in the corpus. m {\displaystyle m} is the total number of tokens (words) in the corpus. === Step 2: Create a semantic 'signature' for each word === For each target word ( w 1 {\displaystyle w_{1}} and w 2 {\displaystyle w_{2}} ), the algorithm creates a list of its most significant neighbors. This is done by taking the top β {\displaystyle \beta } neighbor words, sorted in descending order by their PMI score with the target word. This list of top neighbors, X w {\displaystyle X^{w}} , acts as a semantic "signature" for the word w {\displaystyle w} . X w = { X i w } {\displaystyle X^{w}=\{X_{i}^{w}\}} , for i = 1 , 2 , … , β {\displaystyle i=1,2,\ldots ,\beta } The size of this list, β {\displaystyle \beta } , is a parameter of the method. === Step 3: Compare the signatures === The algorithm then compares the signatures of w 1 {\displaystyle w_{1}} and w 2 {\displaystyle w_{2}} . It looks for words that are present in both signatures. The similarity of w 1 {\displaystyle w_{1}} to w 2 {\displaystyle w_{2}} is calculated by summing the PMI scores of w 2 {\displaystyle w_{2}} with every word in w 1 {\displaystyle w_{1}} 's signature list. The β {\displaystyle \beta } -PMI summation function defines this score. The score for w 1 {\displaystyle w_{1}} with respect to w 2 {\displaystyle w_{2}} is: f ( w 1 , w 2 , β ) = ∑ i = 1 β ( f pmi ( X i w 1 , w 2 ) ) γ {\displaystyle f(w_{1},w_{2},\beta )=\sum _{i=1}^{\beta }(f^{\text{pmi}}(X_{i}^{w_{1}},w_{2}))^{\gamma }} This sum only includes terms where the PMI value is positive. The exponent γ {\displaystyle \gamma } (with a value > 1) is used to give more weight to neighbors that are more strongly associated with w 2 {\displaystyle w_{2}} . This calculation is done in both directions: The similarity of w 1 {\displaystyle w_{1}} with respect to w 2 {\displaystyle w_{2}} : f ( w 1 , w 2 , β 1 ) = ∑ i = 1 β 1 ( f pmi ( X i w 1 , w 2 ) ) γ {\displaystyle f(w_{1},w_{2},\beta _{1})=\sum _{i=1}^{\beta _{1}}(f^{\text{pmi}}(X_{i}^{w_{1}},w_{2}))^{\gamma }} The similarity of w 2 {\displaystyle w_{2}} with respect to w 1 {\displaystyle w_{1}} : f ( w 2 , w 1 , β 2 ) = ∑ i = 1 β 2 ( f pmi ( X i w 2 , w 1 ) ) γ {\displaystyle f(w_{2},w_{1},\beta _{2})=\sum _{i=1}^{\beta _{2}}(f^{\text{pmi}}(X_{i}^{w_{2}},w_{1}))^{\gamma }} === Step 4: Calculate final similarity score === Finally, the total semantic similarity is the average of the two scores from the previous step. S i m ( w 1 , w 2 ) = f ( w 1 , w 2 , β 1 ) β 1 + f ( w 2 , w 1 , β 2 ) β 2 {\displaystyle \mathrm {Sim} (w_{1},w_{2})={\frac {f(w_{1},w_{2},\beta _{1})}{\beta _{1}}}+{\frac {f(w_{2},w_{1},\beta _{2})}{\beta _{2}}}} This score can be normalized to fall between 0 and 1. For example, using this method, the words cemetery and graveyard achieve a high similarity score of 0.986 (with specific parameter settings).

ComfyUI

ComfyUI is an open source, node-based program that allows users to generate images from a series of text prompts. It uses free diffusion models such as Stable Diffusion as the base model for its image capabilities combined with other tools such as ControlNet and LCM Low-rank adaptation with each tool being represented by a node in the program. == History == ComfyUI was released on GitHub in January 2023. According to comfyanonymous, the creator, a major goal of the project was to improve on existing software designs in terms of the user interface. The creator had been involved with Stability AI but by 3 June 2024 that involvement had ended and an organization called Comfy Org had been created along with the core developers. In July 2024, Nvidia announced support for ComfyUI within its RTX Remix modding software. In August 2024, support was added for the Flux diffusion model developed by Black Forest Labs, and Comfy Org joined the Open Model Initiative created by the Linux Foundation. As of Sept 2025, the project has 89.2k stars on GitHub. ComfyUI is one of the most popular user interfaces for Stable Diffusion, along with Automatic1111. == Features == ComfyUI's main feature is that it is node based. Each node has a function such as "load a model" or "write a prompt". The nodes are connected to form a control-flow graph called a workflow. When a prompt is queued, a highlighted frame appears around the currently executing node, starting from "load checkpoint" and ending with the final image and its save location. Workflows commonly consist of tens of nodes, forming a complex directed acyclic graph. Node types include loading a model, specifying prompts, samplers, schedulers, VAE decoders, face restoration and upscaling models, LoRAs, embeddings, and ControlNets. Several samplers are supported, such as Euler, Euler_a, dpmpp_2m_sde and dpmpp_3m_sde. Workflows can be saved to a file, allowing users to re-use node workflows and share them with other users. The file format for the workflows is in JSON and can be embedded in the generated images. Users have also created custom extensions to the base system which are exposed as new nodes, such as the extension for AnimateDiff, which aims to create videos. ComfyUI has been described as more complex compared to other diffusion UIs such as Automatic1111. A default node group is also included with the program. As of December 2024, 1,674 nodes were supported. ComfyUI Supports multiple text-to-image models including, Stable Diffusion, Flux and Tencent's Hunyuan-DiT, as well as custom models from Civitai like Pony. == LLMVision extension compromise == In June 2024, a hacker group called "Nullbulge" compromised an extension of ComfyUI to add malicious code to it. The compromised extension, called ComfyUI_LLMVISION, was used for integrating the interface with AI language models GPT-4 and Claude 3, and was hosted on GitHub. Nullbulge hosted a list of hundreds of ComfyUI users' login details across multiple services on its website, while users of the extension reported receiving numerous login notifications. vpnMentor conducted security research on the extension and claimed it could "steal crypto wallets, screenshot the user’s screen, expose device information and IP addresses, and steal files that contain certain keywords or extensions". Nullbulge's website claims they targeted users who committed "one of our sins", which included AI-art generation, art theft, promoting cryptocurrency, and any other kind of theft from artists such as from Patreon. They claimed that they were "a collective of individuals who believe in the importance of protecting artists' rights and ensuring fair compensation for their work" and that they believed that "AI-generated artwork is detrimental to the creative industry and should be discouraged".