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Keka HR

Keka HR is a software company that provides cloud-based human resource management and payroll automation software. Keka HR specializes in providing business services in the field of HR technology, payroll automation, recruiting, leave, attendance and performance management. The company was founded by Vijay Yalamanchili on July 21, 2014. The company is headquartered in Hyderabad, with operations in Singapore and the United States. == History == Keka HR was established in 2014 in Hyderabad, Telangana, India. In 2015, the company entered the Indian HR market and received the HYSEA Startup Award. By 2019, Keka HR had surpassed $1 million in annual recurring revenue (ARR). During the COVID-19 pandemic in 2020, the company reported a sevenfold increase in sales. By 2021, the company had raised $1.6 million through Recur Club. In 2022, Keka HR secured $57 million in Series A funding from West Bridge Capital. The company's headquarters are located in Gachibowli, Hyderabad, with offices in Singapore and Seattle, Washington.
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Protocol Builder

Protocol Builder is a tool in programming languages to generate code to build protocols in a fast and reliable way. Network programming for all kinds of protocols (such as TCP, UDP, and SNMP) includes converting data to be transferred to raw bytes in the sending side and parsing these bytes in the receiving side. Protocol builders facilitate this stage, usually by automatically generating the code. Protocol Programming has many components to be developed, these are: server listener, server connection, client connection, packets, and loggers. Most protocol builders implement these components automatically so developers save time and money. Currently, there are two Protocol Builders in the market, one for C++ from UpRedSun which is for TCP and UDP protocols. The second one is for .Net languages which generates the code in C# for TCP Protocols, this tool is called .Net Protocol Builder.
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Apache CarbonData

Apache CarbonData is a free and open-source column-oriented data storage format of the Apache Hadoop ecosystem. It is similar to the other columnar-storage file formats available in Hadoop namely RCFile and ORC. It is compatible with most of the data processing frameworks in the Hadoop environment. It provides efficient data compression and encoding schemes with enhanced performance to handle complex data in bulk. == History == CarbonData was developed at Huawei in 2013. The project was donated to the Apache Community in 2015 submitted to the Apache Incubator in June 2016. The project won top honors in the BlackDuck 2016 Open Source Rookies of the Year's Big Data category. Apache CarbonData has been a top-level Apache Software Foundation (ASF)-sponsored project since May 1, 2017.
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OpenIO

OpenIO offered object storage for a wide range of high-performance applications. OpenIO was founded in 2015 by Laurent Denel (CEO), Jean-François Smigielski (CTO) and five other co-founders; it leveraged open source software, developed since 2006, based on a grid technology that enabled dynamic behaviour and supported heterogenous hardware. In October 2017 OpenIO was completed a $5 million funding rounds. In July 2020 OpenIO had been acquired by OVH and withdrawn from the market to become the core technology of OVHcloud object storage offering. == Software == OpenIO is a software-defined object store that supports S3 and can be deployed on-premises, cloud-hosted or at the edge, on any hardware mix. It has been designed from the beginning for performance and cost-efficiency at any scale, and it has been optimized for Big Data, HPC and AI. OpenIO stores objects within a flat structure within a massively distributed directory with indirections, which allows the data query path to be independent of the number of nodes and the performance not to be affected by the growth of capacity. Servers are organized as a grid of nodes massively distributed, where each node takes part in directory and storage services, which ensures that there is no single point of failure and that new nodes are automatically discovered and immediately available without the need to rebalance data. The software is built on top of a technology that ensures optimal data placement based on real-time metrics and allows the addition or removal of storage devices with automatic performance and load impact optimization. For data protection OpenIO has synchronous and asynchronous replication with multiple copies, and an erasure coding implementation based on Reed-Solomon that can be deployed in one data center or geo-distributed or stretched clusters. The software has a feature that catches all events that occur in the cluster and can pass them up in the stack or to applications running on OpenIO nodes. This enables event-driven computing directly into the storage infrastructure. The open source code is available on Github and it is licensed under AGPL3 for server code and LGPL3 for client code. == Performance == OpenIO claimed in 2019 to have reached 1.372 Tbit/s write speed (171 GB/s) on a cluster of 350 physical machines. The benchmark scenario, conducted under production conditions with standard hardware (commodity servers with 7200 rpm HDDs), consisted in backing up a 38 PB Hadoop datalake via the DistCp command. This level of performance marked, according to analysts, the arrival of a new generation of object storage technologies oriented toward high performance and hyper-scalability.
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Quantum machine learning

Quantum machine learning (QML) is the study of quantum algorithms for machine learning. It often refers to quantum algorithms for machine learning tasks which analyze classical data, sometimes called quantum-enhanced machine learning. QML algorithms use qubits and quantum operations to try to improve the space and time complexity of classical machine learning algorithms. Hybrid QML methods involve both classical and quantum processing, where computationally difficult subroutines are outsourced to a quantum device. These routines can be more complex in nature and executed faster on a quantum computer. Furthermore, quantum algorithms can be used to analyze quantum states instead of classical data. The term "quantum machine learning" is sometimes used to refer classical machine learning methods applied to data generated from quantum experiments (i.e. machine learning of quantum systems), such as learning the phase transitions of a quantum system or creating new quantum experiments. QML also extends to a branch of research that explores methodological and structural similarities between certain physical systems and learning systems, in particular neural networks. For example, some mathematical and numerical techniques from quantum physics are applicable to classical deep learning and vice versa. Furthermore, researchers investigate more abstract notions of learning theory with respect to quantum information, sometimes referred to as "quantum learning theory". == Machine learning with quantum computers == Quantum-enhanced machine learning refers to quantum algorithms that solve tasks in machine learning, thereby improving and often expediting classical machine learning techniques. Such algorithms typically require one to encode the given classical data set into a quantum computer to make it accessible for quantum information processing. Subsequently, quantum information processing routines are applied and the result of the quantum computation is read out by measuring the quantum system. For example, the outcome of the measurement of a qubit reveals the result of a binary classification task. While many proposals of QML algorithms are still purely theoretical and require a full-scale universal quantum computer to be tested, others have been implemented on small-scale or special purpose quantum devices. === Quantum associative memories and quantum pattern recognition === Early work on quantum associative memories has been done by Dan Ventura and Tony Martinez and by Carlo A. Trugenberger in the late 1990s and early 2000s. Associative (or content-addressable) memories are able to recognize stored content on the basis of a similarity measure, while random access memories are accessed by the address of stored information and not its content. As such they must be able to retrieve both incomplete and corrupted patterns, the essential machine learning task of pattern recognition. Typical classical associative memories store p patterns in the O ( n 2 ) {\displaystyle O(n^{2})} interactions (synapses) of a real, symmetric energy matrix over a network of n artificial neurons. The encoding is such that the desired patterns are local minima of the energy functional and retrieval is done by minimizing the total energy, starting from an initial configuration. Unfortunately, classical associative memories are severely limited by the phenomenon of cross-talk. When too many patterns are stored, spurious memories appear which quickly proliferate, so that the energy landscape becomes disordered and no retrieval is anymore possible. The number of storable patterns is typically limited by a linear function of the number of neurons, p ≤ O ( n ) {\displaystyle p\leq O(n)} . Quantum associative memories (in their simplest realization) store patterns in a unitary matrix U acting on the Hilbert space of n qubits. Retrieval is realized by the unitary evolution of a fixed initial state to a quantum superposition of the desired patterns with probability distribution peaked on the most similar pattern to an input. By its very quantum nature, the retrieval process is thus probabilistic. Because quantum associative memories are free from cross-talk, however, spurious memories are never generated. Correspondingly, they have a superior capacity than classical ones. The number of parameters in the unitary matrix U is O ( p n ) {\displaystyle O(pn)} . One can thus have efficient, spurious-memory-free quantum associative memories for any polynomial number of patterns. If the matrix U is encoded as a unique operator (as opposed as to a sequence of gates as in the circuit model), e.g. by an optical interferometer, the retrieval becomes efficient even for an exponential number of patterns. === Linear algebra simulation with quantum amplitudes === A number of quantum algorithms for machine learning are based on the idea of amplitude encoding, that is, to associate the amplitudes of a quantum state with the inputs and outputs of computations. Since a state of n {\displaystyle n} qubits is described by 2 n {\displaystyle 2^{n}} complex amplitudes, this information encoding can allow for an exponentially compact representation. Intuitively, this corresponds to associating a discrete probability distribution over binary random variables with a classical vector. The goal of algorithms based on amplitude encoding is to formulate quantum algorithms whose resources grow polynomially in the number of qubits n {\displaystyle n} , which amounts to a logarithmic time complexity in the number of amplitudes and thereby the dimension of the input. Many QML algorithms in this category are based on variations of the quantum algorithm for linear systems of equations (colloquially called HHL, after the paper's authors) which, under specific conditions, performs a matrix inversion using an amount of physical resources growing only logarithmically in the dimensions of the matrix. One of these conditions is that a Hamiltonian which entry-wise corresponds to the matrix can be simulated efficiently, which is known to be possible if the matrix is sparse or low rank. For reference, any known classical algorithm for matrix inversion requires a number of operations that grows more than quadratically in the dimension of the matrix (e.g. O ( n 2.373 ) {\displaystyle O{\mathord {\left(n^{2.373}\right)}}} ), but they are not restricted to sparse matrices. Quantum matrix inversion can be applied to machine learning methods in which the training reduces to solving a linear system of equations, for example in least-squares linear regression, the least-squares version of support vector machines, and Gaussian processes. A crucial bottleneck of methods that simulate linear algebra computations with the amplitudes of quantum states is state preparation, which often requires one to initialise a quantum system in a state whose amplitudes reflect the features of the entire dataset. Although efficient methods for state preparation are known for specific cases, this step easily hides the complexity of the task. === Variational quantum algorithms (VQAs) === In a variational quantum algorithm, a classical computer optimizes the parameters used to prepare a quantum state, while a quantum computer is used to do the actual state preparation and measurement. VQAs are considered promising candidates for noisy intermediate-scale quantum computers. Variational quantum circuits (or parameterized quantum circuits) are a popular class of VQAs where the parameters are those used in a fixed quantum circuit. Researchers have studied VQCs to solve optimization problems and find the ground state energy of complex quantum systems, which were difficult to solve using a classical computer. === Quantum binary classifier === Pattern reorganization is one of the important tasks of machine learning, binary classification is one of the tools or algorithms to find patterns. Binary classification is used in supervised learning and in unsupervised learning. In QML, classical bits are converted to qubits and they are mapped to Hilbert space; complex value data are used in a quantum binary classifier to use the advantage of Hilbert space. By exploiting the quantum mechanic properties such as superposition, entanglement, interference the quantum binary classifier produces the accurate result in short period of time. === Quantum machine learning algorithms based on Grover search === Another approach to improving classical machine learning with quantum information processing uses amplitude amplification methods based on Grover's search algorithm, which has been shown to solve unstructured search problems with a quadratic speedup compared to classical algorithms. These quantum routines can be employed for learning algorithms that translate into an unstructured search task, as can be done, for instance, in the case of the k-medians and the k-nearest neighbors algorithms. Other applications include quadratic speedups in the training of perceptrons. An e
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IWork

iWork is an office suite of applications created by Apple for its macOS, iPadOS, and iOS operating systems, and also available cross-platform through the iCloud website. iWork includes the presentation application Keynote, the word-processing and desktop-publishing application Pages, and the spreadsheet application Numbers. Apple's design goals in creating iWork have been to allow Mac users to easily create attractive documents and spreadsheets, making use of macOS's extensive font library, integrated spelling checker, sophisticated graphics APIs and its AppleScript automation framework. The equivalent Microsoft Office applications to Pages, Numbers, and Keynote are Word, Excel, and PowerPoint, respectively. Although Microsoft Office applications cannot open iWork documents, iWork applications can open Office documents for editing, and export documents from iWork's native formats (.pages, .numbers, .key) to Microsoft Office formats (.docx, .xlsx, .pptx, etc.) as well as to PDF files. The oldest application in iWork is Keynote, first released as a standalone application in 2003 for use by Steve Jobs in his presentations. Steve Jobs announced Keynote saying "It's for when your presentation really matters". Pages was released with the first iWork bundle in 2004; Numbers was added in 2007 with the release of iWork '08. The next release, iWork '09, also included beta access to iWork.com, an online service that allowed users to upload and share documents on the web, now integrated into Apple's iCloud service. A version of iWork for iOS was released in 2010 with the first iPad, and the apps have been regularly updated since, including the addition of iPhone support. In 2013, Apple launched iWork web apps in iCloud; even years later, however, their functionality is somewhat limited compared to equivalents on the desktop. iWork was initially sold as a suite for $79, then later at $19.99 per app on OS X and $9.99 per app on iOS. Apple announced in October 2013 that all iOS and OS X devices purchased onwards, whether new or refurbished, would be eligible for a free download of all three iWork apps: after device setup, the user can "claim" the apps on the App Store, after which they are permanently linked to the user’s Apple ID. iWork for iCloud, which also incorporates a document hosting service, is free to all iCloud users. iWork was released for free on macOS and iOS (including older or resold devices) in April 2017. In September 2016, Apple announced that the real-time collaboration feature would be available for all iWork apps. == History == The first version of iWork, iWork '05, was announced on January 11, 2005 at the Macworld Conference & Expo and made available on January 22 in the United States and on January 29 worldwide. iWork '05 comprised two applications: Keynote 2, a presentation creation program, and Pages, a word processor. iWork '05 was sold for US$79. A 30-day trial was also made available for download on Apple's website. Originally IGG Software held the rights to the name iWork. While iWork was billed by Apple as "a successor to AppleWorks", it does not replicate AppleWorks's database and drawing tools. However, iWork integrates with existing applications from Apple's iLife suite through the Media Browser, which allows users to drag and drop music from iTunes, movies from iMovie, and photos from iPhoto and Aperture directly into iWork documents. iWork '06 was released on January 10, 2006 and contained updated versions of both Keynote and Pages. Both programs were released as universal binaries for the first time, allowing them to run natively on both PowerPC processors and the Intel processors used in the new iMac desktop computers and MacBook Pro notebooks which had been announced on the same day as the new iWork suite. The next version of the suite, iWork '08, was announced and released on August 7, 2007 at a special media event at Apple's campus in Cupertino, California. iWork '08, like previous updates, contained updated versions of Keynote and Pages. A new spreadsheet application, Numbers, was also introduced. Numbers differed from other spreadsheet applications, including Microsoft Excel, in that it allowed users to create documents containing multiple spreadsheets on a flexible canvas using a number of built-in templates. iWork '09, was announced on January 6, 2009 and released the same day. It contains updated versions of all three applications in the suite. iWork '09 also included access to a beta version of the iWork.com service, which allowed users to share documents online until that service was decommissioned at the end of July 2012. Users of iWork '09 could upload a document directly from Pages, Keynote, or Numbers and invite others to view it online. Viewers could write notes and comments in the document, and download a copy in iWork, Microsoft Office, or PDF formats. iWork '09 was also released with the Mac App Store on January 6, 2011 at $19.99 per application, and received regular updates after this point, including links to iCloud and a high-DPI version designed to match Apple's MacBook Pro with Retina Display. On January 27, 2010, Apple announced iWork for iPad, to be available as three separate $9.99 applications from the App Store. This version has also received regular updates including a version for pocket iPhone and iPod Touch devices, and an update to take advantage of Retina Display devices and the larger screens of recent iPhones. On October 22, 2013, Apple announced an overhaul of the iWork software for both the Mac and iOS. Both suites were made available via the respective App Stores. The update is free for current iWork owners and was also made available free of charge for anyone purchasing an OS X or iOS device after October 1, 2013. Any user activating the newly free iWork apps on a qualifying device can download the same apps on another iOS or OS X device logged into the same App Store account. The new OS X versions have been criticized for losing features such as multiple selection, linked text boxes, bookmarks, 2-up page views, mail merge, searchable comments, ability to read/export RTF files, default zoom and page count, integration with AppleScript. Apple has provided a road-map for feature re-introduction, stating that it hopes to reintroduce some missing features within the next six months. As of April 1, 2014 a few features—e.g., the ability to set the default zoom—had been reintroduced, though scores had not. Due to using a completely new file format that can work across macOS, Windows, and in most web browsers by using the online iCloud web apps, versions of iWork beginning with iWork 13 and later do not open or allow editing of documents created in versions prior to iWork '09, with users who attempt to open older iWork files being given a pop-up in the new iWork 13 app versions telling them to use the previous iWork '09 (which users may or may not have on their machine) in order to open and edit such files. Accordingly, the current version for OS X (which was initially only compatible with OS X Mavericks 10.9 onwards) moves any previously installed iWork '09 apps to an iWork '09 folder on the users machine (in /Applications/iWork '09/), as a work-around to allow users continued use of the earlier suite in order to open and edit older iWork documents locally on their machine. In October 2015, Apple released an update to mitigate this issue, allowing users to open documents saved in iWork '06 and iWork '08 formats in the latest version of Pages. In 2016, Apple announced that the real-time collaboration feature would be available for all iWork apps, instead of being constrained to using iWork for iCloud. The feature is comparable to Google Docs. == Versions == === Major releases === === Updates === iWork '09 received several updates: iWork 9.0.3 DVD (for Mac OS X 10.5.6 "Leopard" or newer; released August 26, 2010) iWork 9.0.4 (for Mac OS X 10.5.6 "Leopard" or newer; released August 26, 2010) iWork 9.1 (for Mac OS X 10.6.6 "Snow Leopard" or newer; released July 20, 2011) iWork 9.3 (for Mac OS X 10.7.4 "Lion" or newer; released December 4, 2012) The Mac App Store version of iWork was updated on October 15, 2015 for 10.10 "Yosemite" or newer. It is the final release to support 10.10 "Yosemite" and 10.11 "El Capitan". Keynote 6.6, Pages 5.6 and Numbers 3.6 are included. iWork received a major update again on March 28, 2019 with Keynote 9.0, Pages 8.0 and Numbers 6.0. == Components == === Common components === Products in the iWork suite share a number of components, largely as a result of sharing underlying code from the Cocoa and similar shared application programming interfaces (APIs). Among these are the well known universal multilingual spell checker, which can also be found in products like Safari and Mail. Grammar checking, find and replace, style and color pickers are similar examples of design features found throughout the Apple application space. Moreover, the applications
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Color image pipeline

An image pipeline or video pipeline is the set of components commonly used between an image source (such as a camera, a scanner, or the rendering engine in a computer game), and an image renderer (such as a television set, a computer screen, a computer printer or cinema screen), or for performing any intermediate digital image processing consisting of two or more separate processing blocks. An image/video pipeline may be implemented as computer software, in a digital signal processor, on an FPGA, or as fixed-function ASIC. In addition, analog circuits can be used to do many of the same functions. Typical components include image sensor corrections (including debayering or applying a Bayer filter), noise reduction, image scaling, gamma correction, image enhancement, colorspace conversion (between formats such as RGB, YUV or YCbCr), chroma subsampling, framerate conversion, image compression/video compression (such as JPEG), and computer data storage/data transmission. Typical goals of an imaging pipeline may be perceptually pleasing end-results, colorimetric precision, a high degree of flexibility, low cost/low CPU utilization/long battery life, or reduction in bandwidth/file size. Some functions may be algorithmically linear. Mathematically, those elements can be connected in any order without changing the end-result. As digital computers use a finite approximation to numerical computing, this is in practice not true. Other elements may be non-linear or time-variant. For both cases, there is often one or a few sequences of components that makes sense for optimum precision and minimum hardware-cost/CPU-load.
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Elements (toolchain)

RemObjects Elements is a toolchain for software development, comprising six programming languages: C#, Swift, Go, Java, Oxygene (a form of modern Object Pascal), and Visual Basic .NET. All languages interoperate, meaning a single project can use any combination of languages, and they can all be compiled to .NET, the JVM, native, or WebAssembly. Elements supports Microsoft Windows, all Apple Inc. platforms (including iOS, visionOS and watchOS), Android, and Linux. Elements also supports language conversion, allowing source code in one language to be rewritten in another. Elements is supported in Visual Studio, but RemObjects also makes their own IDEs, Fire (on MacOS) and Water (on Windows.) == Background == RemObjects began in 2002, creating software for Delphi, but in 2005 in response to the growth of .NET and that Delphi was targeting only native Windows, they released Oxygene (known as Chrome at the time) as a new version of Object Pascal, with more modern syntax as well as being .NET-native. Since then, five other languages have been added to the suite, as well as compiling for the web via WebAssembly and to native architectures (eg Intel 32/64 or ARM64). Elements is primarily intended for developers who want to pull together libraries and codebases written in multiple languages, including legacy codebases in older languages while modernizing either with newer syntax and features or by adding in the use of newer or more popular languages. Because of the Oxygene flavour of Object Pascal, supporting Delphi apps is a primary focus, including allowing Pascal to be compiled for other architectures or providing language features that match other prominent languages. == Approach == New versions of the Elements come out approximately every week. RemObjects names its programming languages after chemical elements, sometimes with poetic or musical spelling, rather than referring to them directly. They are: C#: Hydrogene Object Pascal: Oxygene Java: Iodine Visual Basic: Mercury Go: Gold Swift: Silver == History == The Elements compiler was first introduced with version 1.0 in 2005 under the name "Chrome", with support for only the Oxygene language on the .NET platform, primarily as a response to the then-new and not well-received Delphi .NET compiler from Embarcadero. Chrome saw updates to version 1.5 'Floorshow' and Chrome 2.0 'Joyride' over the next few years, moving in parallel with major advancements on the .NET platform for .NET 2.0 (Generics) and .NET 3.x (LINQ), respectively. With the release of version 3.0 (code-named Oxygène after the Jean-Michel Jarre album of the same name) Chrome was rebranded to Oxygene in 2008, and also shipped co-branded by Embarcadero as Delphi Prism (later just Prism) as part of RAD Studio, replacing Embarcadero's own and now-defunct Delphi.NET compiler. 2010 saw the release of Oxygene 4 ("Echoes"), the last version to focus on just a single language and platform. With Oxygene 5 in 2011 and Oxygene 6 in 2013, RemObjects introduced new platform support for Java/Android (code-name "Cooper") and then Cocoa, the Apple development platform (code-name "Toffee"). Elements 7.0 was released at the beginning of 2014, adding the second programming language, C# to the compiler, and delegating Oxygene from the product name to merely branding the Object Pascal-based language. Over the subsequent years, Elements gained support for additional languages, with Apple Swift in 2015, Java in 2017, and subsequently Google's Go and Mercury, a revitalized Visual Basic.NET. Elements also gained support for its fourth target platform, "Island", for CPU-native compilation for Windows, Linux, and WebAssembly. In addition to the chemical elements-based names for the different languages, the "Elements" concept was carried on with the introduction of dedicated development environments alchemically named Fire (for the Mac, in 2015) and Water (for Windows, in 2018). == Fire and Water (IDEs) == Fire and Water are integrated development environments developed by RemObjects Software. They are designed specifically for use with the Elements Compiler. Fire is the version developed for macOS, while Water is intended for Microsoft Windows. Both IDEs are designed to work closely with the Elements compiler and are primarily intended for developers using the RemObjects language ecosystem. They support software development across multiple platforms, including .NET, Android, iOS, macOS, Windows, Linux, and WebAssembly. The IDEs include standard development tools such as syntax highlighting, code completion, debugging, and project navigation. Build operations are managed using a custom system known as EBuild, which is part of the broader Elements toolchain. The IDEs are distributed as part of the RemObjects Elements package and are updated in coordination with the compiler itself. == In media == Oxygene has been mentioned several times by Verity Stob in their Chronicles of Delphi series, currently living at The Register.
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ObjectVision

ObjectVision was a forms-based programming language and environment for Windows 3.x developed by Borland. The latest version, 2.1, was released in 1992. An ObjectVision application is composed by forms designed in a graphic way that contains objects and events to provide interactivity. Forms are connected together with logic in the form of decision trees. ObjectVision applications also can interact with databases using multiple engines, like Paradox and dBase. A finished project is saved as an OVD file, that is executed by an interpreted runtime that can be freely distributed. ObjectVision was not used broadly except in some niche segments, but the visual programming ideas were the basis for Borland Delphi.
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Biomedical data science

Biomedical data science is a multidisciplinary field which leverages large volumes of data to promote biomedical innovation and discovery. Biomedical data science draws from various fields including Biostatistics, Biomedical informatics, and machine learning, with the goal of understanding biological and medical data. It can be viewed as the study and application of data science to solve biomedical problems. Modern biomedical datasets often have specific features which make their analyses difficult, including: Large numbers of feature (sometimes billions), typically far larger than the number of samples (typically tens or hundreds) Noisy and missing data Privacy concerns (e.g., electronic health record confidentiality) Requirement of interpretability from decision makers and regulatory bodies Many biomedical data science projects apply machine learning to such datasets. These characteristics, while also present in many data science applications more generally, make biomedical data science a specific field. Examples of biomedical data science research include: Computational genomics Computational imaging Electronic health records data mining Biomedical network science Clinical Natural Language Processing (NLP) == Computational Imaging and Deep Learning == Computational imaging is a cornerstone of biomedical data science, focusing on the development of algorithms to enhance, analyze, and interpret medical imagery. In recent years, the field has been transformed by the integration of deep learning, particularly through the use of Convolutional Neural Networks. Deep learning started from researchers manually defining characteristics like edge detection or texture representation learning. In a more modern approach of computational imaging, models automatically learn a hierarchy of features directly from raw pixel data. This overlap between data science and deep learning is applied across several key tasks: Classification: Identifying the presence of specific diseases, such as distinguishing between benign and malignant tumors in histopathology slides or detecting pneumonia in chest X-rays. Segmentation: The precise delineation of anatomical structures or lesions. A notable example is the U-Net architecture, which is widely used for biomedical image segmentation to help clinicians quantify organ volume or track tumor growth. Detection: Automating the localization of small objects, such as identifying microcalcifications in mammograms or polyps during colonoscopies. Registration: The process of aligning multiple images to provide a comprehensive view of the patient's anatomy. Even with all of these enhancements, the application of deep learning in medical imaging requires accomplishing vigorous challenges. An example of these changes is building large, annotated datasets and creating the imperative for model interpretability in clinical decision-making. == Electronic Health Records == Electronic Health Records (EHRs) are a digital alternative to patient paper charts, usually including individual records or population health information. EHRs can be used in a wide variety of applications, including research and analysation as they often include demographics, diagnoses, medications, test results, and personal statistics. === History === ==== 1960s ==== The earliest precursor is considered Dr. Lawrence Weed's problem-oriented medical record (POMR) published in the 1968 which sorts and groups medical records by medical diagnoses and symptoms. The POMR was the first system to organize based off of patient information rather than the source (doctors, nurses, attendings, etc.). In 1969, the Regenstrief Institute developed and published the Regenstrief Medical Record System which established electronic writing, storage, and retrieval of records which served as the basis for modern EHR systems. ==== 2000s ==== In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH Act) was passed in the United States. This act standardized privacy and distribution of EHRs and increased the acceptance and utilization of EHRs within medical and academic settings. == Artificial Intelligence and Machine Learning Applications == Machine Learning and Artificial Intelligence have become central tools in biomedical data science. Recent advances in large language models (LLMs) have expanded their role beyond text, with models trained directly on genomic sequences enabling tasks such as gene function prediction, variant effect analysis, and drug discovery. In clinical settings, Natural Language Processing (NLP) models are applied to electronic health records to extract structured insights from unstructured clinical notes and data, supporting diagnosis and treatment planning. Beyond genomics, AI models have been applied to protein structure prediction. AlphaFold, developed by Google DeepMind, uses deep learning to predict three-dimensional protein structures from amino acid sequences with high accuracy. These predictions have been used to support drug target identification and the study of disease mechanisms. == Knowledge Graphs == Knowledge graphs (KGs) are widely used in biomedical data science to represent and analyze complex relationships among biological and medical entities. By structuring data as nodes (e.g., genes, diseases, drugs) and edges (relationships), KGs enable computational methods to extract insights and support decision-making. These biomedical relationships can be efficiently modeled and queried using technologies such as Neo4j. === Biomedical Research Applications === KGs provide biomedical researchers with a way to model complex biological systems. They have been used to identify the relationships between diseases and biomolecules, support drug repurposing, and to uncover new biological insights. Additional applications include: Identification of novel antibiotic resistance genes through graph-based link prediction. Finding associations between miRNA and diseases. Prediction of protein-protein interactions. === Clinical Applications === In clinical settings, KGs can be used to make visual representations of a patient's electronic health records. The data obtained from these graphs can assist healthcare providers in improving patient diagnoses and prescribing more effective drugs. Additionally, embeddings derived from resources like the Unified Medical Language System (UMLS) enable natural language processing of clinical text and similarity analysis between medical concepts. === Limitations === Despite their advantages, knowledge graphs face several challenges. Some of these include: High algorithmic complexity and large biological datasets make the process computationally expensive. KG construction can be a time-consuming process that requires careful attention to assign appropriate node types and vocabularies. Using data from a wide range of datasets in one KG requires them to be effectively integrated. == Privacy == A primary challenge in biomedical data science is maintaining medical privacy. Conducting research requires that data be collected on a number of people for training and testing purposes and is stored within biomedical datasets. This poses a risk for violating patient confidentiality and may dissuade people from participating in studies. The main sources of health statistics are surveys administrative and medical records health care claims data, vital records surveillance disease registries grey literature and peer-reviewed literature. Large data collection is a useful tool for researching various medical conditions. Researchers use these large datasets of information to identify factors that may make people more susceptible to certain diseases. Large amounts of collected data can help researchers identify patterns for disease probabilities. The findings can show a person is more likely for a condition, or identify environmental, social, and personal habits that may lead to adverse health issues. Institutions researching using personal medical information come with a moral and legal responsibility to protect the use of that information. Protection of the collected information has become a big concern. Sophisticated and coordinated attacks on certain medical systems happen more frequently. Medical companies, medical insurance and private businesses have invested a great deal into the protection of personal data. Despite this, data breaches continue to be documented. The chart below shows the top healthcare breaches in 2025. For these reasons, many people have reservations about giving up their personal data. Aside from the legitimate use of personal data there have been instances where companies have found methods to profit from brokering medical information. Concerns exist regarding unauthorized use of sensitive information within these data companies. If a person is identified within a dataset, then sensitive data can be used to discriminate against them. For example, insurance companies may charge a hi
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Deblurring

Deblurring is the process of removing blurring artifacts from images. Deblurring recovers a sharp image S from a blurred image B, where S is convolved with K (the blur kernel) to generate B. Mathematically, this can be represented as B = S ∗ K {\displaystyle B=SK} (where represents convolution). While this process is sometimes known as unblurring, deblurring is the correct technical word. The blur K is typically modeled as point spread function and is convolved with a hypothetical sharp image S to get B, where both the S (which is to be recovered) and the point spread function K are unknown. This is an example of an inverse problem. In almost all cases, there is insufficient information in the blurred image to uniquely determine a plausible original image, making it an ill-posed problem. In addition the blurred image contains additional noise which complicates the task of determining the original image. This is generally solved by the use of a regularization term to attempt to eliminate implausible solutions. This problem is analogous to echo removal in the signal processing domain. Nevertheless, when coherent beam is used for imaging, the point spread function can be modeled mathematically. By proper deconvolution of the point spread function K and the blurred image B, the blurred image B can be deblurred (unblur) and the sharp image S can be recovered.
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Poop Map

Poop Map is a social app where users can track on a map where and when they defecate. In addition to logging location and time of each bowel movement, users can also add a photo, "like" other users' logs, and rate each account. The social elements of the app allow for groups of users to create a competitive league. Certain behaviors unlock achievements in-app. == Development == The app was created by app developer Nino Uzelac. It was launched in July 2013. == Popularity == The app charted at number one on the Apple App Store charts in 2021 after going viral on TikTok. As of September 2024, the app has a 4.8 rating on the App Store and more than 58,000 ratings. It also has more than one million downloads on the Google Play Store. Poop Map is notably popular among hikers, and has been written about in the outdoors magazine Outside.
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Decision list

Decision lists are a representation for Boolean functions which can be easily learned from examples. Single term decision lists are more expressive than disjunctions and conjunctions; however, 1-term decision lists are less expressive than the general disjunctive normal form and the conjunctive normal form. The language specified by a k-length decision list includes as a subset the language specified by a k-depth decision tree. Learning decision lists can be used for attribute efficient learning, a type of machine learning. == Definition == A decision list (DL) of length r is of the form: if f1 then output b1 else if f2 then output b2 ... else if fr then output br where fi is the ith formula and bi is the ith boolean for i ∈ { 1... r } {\displaystyle i\in \{1...r\}} . The last if-then-else is the default case, which means formula fr is always equal to true. A k-DL is a decision list where all of formulas have at most k terms. Sometimes "decision list" is used to refer to a 1-DL, where all of the formulas are either a variable or its negation.
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Server.com

Server.com is a domain name that was owned by software as a service (SaaS) company Server Corporation. They offered a suite of services from 1996 until 2007. It was the first SaaS site to offer a variety of services and the first to use the term WebApp to describe its services. It was selected as an Incredibly Useful Site by Yahoo! Internet Life magazine. net magazine listed Server.com among the 100 most influential websites of all time. Server.com launched in 1996 offering the first online personal information manager. In 1997, they rolled out the first threaded message board service; the first web based mailing list manager; one of the first online calendar services; and one of the first online form builders. In 2000, Server.com partnered with NBCi and became server.snap.com until 2001. In 2001, Server.com was serving 100 million monthly pageviews. Media Life declared it one of the 20 biggest ad domains on the Web. In 2002, Server.com developed one of the first web-based RSS aggregators. In 2007, all services were moved to YourWebApps.com. The domain name Server.com was sold in 2009 for $770,000.
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Scikit-learn

scikit-learn (formerly scikits.learn and also known as sklearn) is a free and open-source machine learning library for the Python programming language. It features various classification, regression and clustering algorithms including support-vector machines, random forests, gradient boosting, k-means and DBSCAN, and is designed to interoperate with the Python numerical and scientific libraries NumPy and SciPy. Scikit-learn is a NumFOCUS fiscally sponsored project. == Overview == The scikit-learn project started as scikits.learn, a Google Summer of Code project by French data scientist David Cournapeau. The name of the project derives from its role as a "scientific toolkit for machine learning", originally developed and distributed as a third-party extension to SciPy. The original codebase was later rewritten by other developers. In 2010, contributors Fabian Pedregosa, Gaël Varoquaux, Alexandre Gramfort and Vincent Michel, from the French Institute for Research in Computer Science and Automation in Saclay, France, took leadership of the project and released the first public version of the library on February 1, 2010. In November 2012, scikit-learn as well as scikit-image were described as two of the "well-maintained and popular" scikits libraries. In 2019, it was noted that scikit-learn is one of the most popular machine learning libraries on GitHub. At that time, the project had over 1,400 contributors and the documentation received 42 million visits in 2018. According to a 2022 Kaggle survey of nearly 24,000 respondents from 173 countries, scikit-learn was identified as the most widely used machine learning framework. == Features == Large catalogue of well-established machine learning algorithms and data pre-processing methods (i.e. feature engineering) Utility methods for common data-science tasks, such as splitting data into train and test sets, cross-validation and grid search Consistent way of running machine learning models (estimator.fit() and estimator.predict()), which libraries can implement Declarative way of structuring a data science process (the Pipeline), including data pre-processing and model fitting == Examples == Fitting a random forest classifier: == Implementation == scikit-learn is largely written in Python, and uses NumPy extensively for high-performance linear algebra and array operations. Furthermore, some core algorithms are written in Cython to improve performance. Support vector machines are implemented by a Cython wrapper around LIBSVM; logistic regression and linear support vector machines by a similar wrapper around LIBLINEAR. In such cases, extending these methods with Python may not be possible. scikit-learn integrates well with many other Python libraries, such as Matplotlib and plotly for plotting, NumPy for array vectorization, Pandas dataframes, SciPy, and many more. == History == scikit-learn was initially developed by David Cournapeau as a Google Summer of Code project in 2007. Later that year, Matthieu Brucher joined the project and started to use it as a part of his thesis work. In 2010, INRIA, the French Institute for Research in Computer Science and Automation, got involved and the first public release (v0.1 beta) was published in late January 2010. The project released its first stable version, 1.0.0, on September 24, 2021. The release was the result of over 2,100 merged pull requests, approximately 800 of which were dedicated to improving documentation. Development continues to focus on bug fixes, efficiency and feature expansion. The latest version, 1.8, was released on December 10, 2025. This update introduced native Array API support, enabling the library to perform GPU computations by directly using PyTorch and CuPy arrays. This version also included bug fixes, improvements and new features, such as efficiency improvements to the fit time of linear models. == Applications == Scikit-learn is widely used across industries for a variety of machine learning tasks such as classification, regression, clustering, and model selection. The following are real-world applications of the library: === Finance and Insurance === AXA uses scikit-learn to speed up the compensation process for car accidents and to detect insurance fraud. Zopa, a peer-to-peer lending platform, employs scikit-learn for credit risk modelling, fraud detection, marketing segmentation, and loan pricing. BNP Paribas Cardif uses scikit-learn to improve the dispatching of incoming mail and manage internal model risk governance through pipelines that reduce operational and overfitting risks. J.P. Morgan reports broad usage of scikit-learn across the bank for classification tasks and predictive analytics in financial decision-making. === Retail and E-Commerce === Booking.com uses scikit-learn for hotel and destination recommendation systems, fraudulent reservation detection, and workforce scheduling for customer support agents. HowAboutWe uses it to predict user engagement and preferences on a dating platform. Lovely leverages the library to understand user behaviour and detect fraudulent activity on its platform. Data Publica uses it for customer segmentation based on the success of past partnerships. Otto Group integrates scikit-learn throughout its data science stack, particularly in logistics optimization and product recommendations. === Media, Marketing, and Social Platforms === Spotify applies scikit-learn in its recommendation systems. Betaworks uses the library for both recommendation systems (e.g., for Digg) and dynamic subspace clustering applied to weather forecasting data. PeerIndex used scikit-learn for missing data imputation, tweet classification, and community clustering in social media analytics. Bestofmedia Group employs it for spam detection and ad click prediction. Machinalis utilizes scikit-learn for click-through rate prediction and relational information extraction for content classification and advertising optimization. Change.org applies scikit-learn for targeted email outreach based on user behaviour. === Technology === AWeber uses scikit-learn to extract features from emails and build pipelines for managing large-scale email campaigns. Solido applies it to semiconductor design tasks such as rare-event estimation and worst-case verification using statistical learning. Evernote, Dataiku, and other tech companies employ scikit-learn in prototyping and production workflows due to its consistent API and integration with the Python ecosystem. === Academia === Télécom ParisTech integrates scikit-learn in hands-on coursework and assignments as part of its machine learning curriculum. == Awards == 2019 Inria-French Academy of Sciences-Dassault Systèmes Innovation Prize: Awarded in recognition of scikit-learn's impact as a major free software breakthrough in machine learning and its role in the digital transformation of science and industry. 2022 Open Science Award for Open Source Research Software: Awarded by the French Ministry of Higher Education and Research as part of the second National Plan for Open Science. The project was recognized in the "Community" category for its technical quality, its large international contributor network, and the quality of its documentation.
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