AI For Business Owners Course

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Customer support

Customer support is a range of services to assist customers in making cost effective and correct use of a product. It includes assistance in planning, installation, training, troubleshooting, maintenance, upgrading, and disposal of a product. Regarding technology products such as mobile phones, televisions, computers, software products or other electronic or mechanical goods, it is termed technical support. It aims to ensure users can effectively operate the product and resolve any issues that may arise throughout its lifecycle. Support is delivered through various channels, including telephone, email, live chat, self-service knowledge bases, and social media. Research indicates that most customers attempt to resolve issues through self-service before contacting a representative. For products sold across multiple regions, support may be provided in several languages, as consumers tend to prefer assistance in their native language. Requirements for customer contact centres are defined in international standards such as ISO 18295.
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Supreme Commander (video game)

Supreme Commander (sometimes SupCom) is a 2007 real-time strategy video game designed by Chris Taylor and developed by his company, Gas Powered Games. The game is considered to be a spiritual successor, not a direct sequel, to Taylor's 1997 game Total Annihilation. First announced in the August 2005 edition of PC Gamer magazine, the game was released in Europe on February 16, 2007, and in North America on February 20. The standalone expansion Supreme Commander: Forged Alliance was released on November 6 of the same year. The sequel, Supreme Commander 2, was released in 2010. Nowadays, the original Supreme Commander is played through the community client called Forged Alliance Forever; the game has been further developed and balanced, and offers a wide variety of community mods. The gameplay of Supreme Commander focuses on using a giant bipedal mech called an Armored Command Unit (ACU), the so-called "Supreme Commander", to build a base, upgrading units to reach higher technology tiers, and conquering opponents. The player can command one of three factions: the Aeon Illuminate, the Cybran Nation, or the United Earth Federation (UEF). The expansion game added the Seraphim faction. Supreme Commander was highly anticipated in pre-release previews, and was well received by critics, with a Metacritic average of 86 out of 100. == Gameplay == Supreme Commander, like its spiritual predecessors, Total Annihilation and Spring, begins with the player solely possessing a single, irreplaceable construction unit called the "Armored Command Unit," or ACU, the titular Supreme Commander. Normally the loss of this unit results in the loss of the game (Skirmish missions can be set for a variety of victory conditions). These mech suits are designed to be transported through quantum gateways across the galaxy and contain all the materials and blueprints necessary to create an army from a planet's native resources in hours. All standard units except Commanders and summoned Support Commanders (sACU) are self-sufficient robots. All units and structures belong to one of four technology tiers, or "Tech" levels, each tier being stronger and/or more efficient than the previous. Certain lower-tier structures can be upgraded into higher ones without having to rebuild them. The first tier is available at the start of the game and consists of small, relatively weak units and structures. The second tier expands the player's abilities greatly, especially in terms of stationary weapons and shielding, and introduces upgraded versions of tier one units. The third tier level has very powerful assault units designed to overcome the fortifications of the most entrenched player. The fourth tier is a limited range of "experimental" technology. These are usually massive units which take a lot of time and energy to produce, but provide a significant tactical advantage. Supreme Commander features a varied skirmish AI. The typical Easy' and Normal modes are present, but the Hard difficulty level has four possible variants. Horde AI will swarm the player with hordes of lower level units, Tech AI will upgrade its units as fast as possible and assault the player with advanced units, the Balanced AI attempts to find a balance between the two, and the Supreme AI decides which of the three hard strategies is best for the map. The single player campaign consists of eighteen missions, six for each faction. The player is an inexperienced Commander who plays a key role in their faction's campaign to bring the "Infinite War" to an end. Despite the low number of campaign missions, each mission can potentially last hours. At the start of a mission, objectives are assigned for the player to complete. Once the player accomplishes them, the map is expanded, sometimes doubling or tripling in size, and new objectives are assigned. As the mission is commonly divided into three segments, the player will often have to overcome several enemy positions to achieve victory. === Resource management === Because humans have developed replication technology, making advanced use of rapid prototyping and nanotechnology, only two types of resources are required to wage war: Energy and Mass. Energy is obtained by constructing power generators on any solid surface (except fuel generators, which can only be built on fuel deposits), while Mass is obtained either by placing mass extractors on limited mass deposit spots (the most efficient method, although it requires map control) or by building mass fabricators to convert energy into mass. Constructor units can gather energy by "reclaiming" it from organic debris such as trees and mass from rocks and wrecked units. Each player has a certain amount of resource storage, which can be expanded by the construction of storage structures. This gives the player reserves in times of shortage or allows them to stockpile resources. If the resource generation exceeds the player's capacity, the material is wasted. On the contrary, if the storages are depleted and the demand of one of the resources exceeds the production, then all the productions speed is reduced. In addition, if an energy deficit occurs, shields will stop working. An adjacency system allows certain structures to benefit from being built directly adjacent to others. Energy-consuming structures will use less energy when built adjacent to power generators and power generators will produce more energy when built adjacent to power storage structures. The same applies to their mass-producing equivalents. Likewise, factories will consume less energy and mass when built adjacent to power generators and mass fabricators/extractors, respectively. However, by placing structures in close proximity, they become more vulnerable to collateral damage if an adjacent structure is destroyed. Furthermore, most resource generation structures can cause chain reactions when destroyed (especially Tier III structures, which produce large amounts of resources but often have large detonations that can wipe out a nearby army). === Warfare === Supreme Commander uses a "strategic zoom" system that allows the player to seamlessly zoom from a detailed close up view of an individual unit all the way out to a view of the entire map, at which point it resembles a fullscreen version of the minimap denoting individual units with icons. The camera also has a free movement mode and can be slaved to track a selected unit and there is a split screen mode which also supports multiple monitors. This system allows Supreme Commander to use vast maps up to 80 km x 80 km, with players potentially controlling a thousand units each. Units in Supreme Commander are built to scale as they would be in the real world. For example, battleships dwarf submarines. Late into the game, the larger "experimental" units, such as the Cybran Monkeylord, an enormous spider-shaped assault unit, can actually crush smaller enemy units by stepping on them. Because of the wide range of planets colonized by humanity in the setting, the theatres of war range from desert to arctic, and all battlespaces are employed. Technologies emerging in modern warfare are frequently employed in Supreme Commander. For example, stealth technology and both tactical and strategic missile and missile defense systems can be used. Supreme Commander introduced several innovations designed to reduce the amount of micromanagement inherent in many RTS games. Engineers units have the command "assist", that will help follow other engineers and help them finish their orders or improve production rate of factories. In addition, engineers with the order "patrol" will repair units, buildings and recycle wrecks in their along their patrol route. Holding the shift key causes any orders given to a unit (or group of units) to be queued. In this manner a unit may be ordered to attack several targets in succession, or to make best speed to a given point on the map and then attack towards a specified location engaging any hostiles it encounters along the way. After orders have been issued, holding the shift key causes all issued orders to be displayed on the map where they can be subsequently modified to accommodate a change of plan. Further, when a unit is ordered to attack a target, the player can issue an order to perform a coordinated attack to another unit. This order coordinates the arrival time of the units at the target automatically by adjusting the speed of the units involved. As in other RTS games, air transports can be used to convey units to specified destinations, in Supreme Commander though by shift queuing orders a transport containing several units can be ordered to drop specific units at subsequent waypoints. An air transport can also be ordered to create a ferry route, an airbridge wherein any land units ordered to the start of the ferry route will be conveyed by the air transport to the specified destination. The output from a production factory can be routed to a ferry route causing all units co
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Clanker

Clanker is a derogatory term for robots and artificial intelligence (AI) software. The term has been used in Star Wars media, first appearing in the franchise's 2005 video game Star Wars: Republic Commando. In 2025, the term became widely used to express hatred or distaste for machines ranging from delivery robots to large language models. This trend has been attributed to anxiety around the negative societal effects of AI. == In science fiction == The term has been previously used in science fiction literature, first appearing in a 1958 article by William Tenn in which he uses it to describe robots from science fiction films like Metropolis. The Star Wars franchise began using the term as a slur against droids in the 2005 video game Star Wars: Republic Commando before being prominently used in the animated series Star Wars: The Clone Wars, which follows a galaxy-wide war between the Galactic Republic's clone troopers and the Confederacy of Independent Systems' battle droids. In Star Wars media, robots—more commonly known as droids—are routinely depicted as the subjects of discrimination. For example, in the original Star Wars film, C-3PO and R2-D2 are abducted by Jawas and sold to the family of Luke Skywalker. When visiting a cantina in Mos Eisley, both droids are refused service by the bartender, who remarks that "We don't serve their kind." In Star Wars lore, the term clanker had entered use by the time of the franchise's High Republic Era and became prominent during the Clone Wars, in which clone troopers regularly use the phrase against battle droids. == AI backlash == The growing popularity of the term clanker reflects an increase in direct contact between people and AI systems. On sidewalks, delivery robots impede mobility and cause safety issues. In digital spaces, cybersecurity experts have raised concerns about the rising number of bots online, which now make up a large portion of internet traffic. A 2025 report estimated that about one in five social media accounts are automated. The term is also a reaction to AI advocacy from industrialists like Elon Musk and Sam Altman, who have championed the integration of AI into nearly every aspect of modern life. This includes efforts by major companies and startups alike, such as Amazon's development of humanoid robots to replace human workers in service industries. Such initiatives have further fueled public skepticism, reinforcing the association of clanker with unease over automation and the displacement of human roles. A global survey conducted by the research firm Gartner in December 2023 found that 64% of customers would prefer companies to avoid using AI in customer service, with another 53% stating they would consider switching to a different company if they discovered AI was handling their service interactions. Another report by Ernst & Young, published in July 2025, found that 42% of employees across Europe are worried that the use of AI in the workplace may threaten their employment. Criticism has also been directed at the technology itself. Some of the backlash stems from concerns about the resource consumption of AI systems, their frequent reliance on copyrighted material without consent, and questions about the intentions of the corporations behind them. There are also concerns about the potential cognitive effects of relying heavily on AI. A study, authored by researchers at Microsoft and Carnegie Mellon University, warns that regular dependence on AI may leave users mentally unprepared for real-world problem solving, likening the effect to cognitive atrophy. In June 2025, United States Senator Ruben Gallego tweeted that his "new bill makes sure you don't have to talk to a clanker if you don't want to", referring to proposed legislation that would require call centers to disclose their use of automated customer service agents to callers in the United States and offer the option to switch to a human representative. == Analysis == Linguist Adam Aleksic has described clanker as an evolution of racial slurs that anthropomorphize robotic systems. Internet memes incorporating the term often reference historical discrimination against marginalized groups such as African Americans. Based on the work of linguist Geoffrey Nunberg, American news website Axios has argued that clanker is merely a derogatory word, rather than a slur, because it does not perpetuate social inequities. NPR has noted the irony that the word robot was coined by Karel Čapek for his 1920 science-fiction play R.U.R. as a similar criticism of industrialization forcing workers to become devoid of their humanity. Aleksic has observed that robot can be further traced to the Proto-Slavic noun orbъ, which means 'slave'. While other science fiction media include pejoratives for androids and robots, such as skinjob and toaster from the Blade Runner and Battlestar Galactica franchises, respectively, clanker is believed to have gained popularity because its usage is intuitive and flexible. Whereas AI slop describes low-quality output from artificial intelligence, clanker belittles the underlying computer systems.
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Type-2 fuzzy sets and systems

Type-2 fuzzy sets and systems generalize standard type-1 fuzzy sets and systems so that more uncertainty can be handled. From the beginning of fuzzy sets, criticism was made about the fact that the membership function of a type-1 fuzzy set has no uncertainty associated with it, something that seems to contradict the word fuzzy, since that word has the connotation of much uncertainty. So, what does one do when there is uncertainty about the value of the membership function? The answer to this question was provided in 1975 by the inventor of fuzzy sets, Lotfi A. Zadeh, when he proposed more sophisticated kinds of fuzzy sets, the first of which he called a "type-2 fuzzy set". A type-2 fuzzy set lets us incorporate uncertainty about the membership function into fuzzy set theory, and is a way to address the above criticism of type-1 fuzzy sets head-on. And, if there is no uncertainty, then a type-2 fuzzy set reduces to a type-1 fuzzy set, which is analogous to probability reducing to determinism when unpredictability vanishes. Type1 fuzzy systems are working with a fixed membership function, while in type-2 fuzzy systems the membership function is fluctuating. A fuzzy set determines how input values are converted into fuzzy variables. == Overview == In order to symbolically distinguish between a type-1 fuzzy set and a type-2 fuzzy set, a tilde symbol is put over the symbol for the fuzzy set; so, A denotes a type-1 fuzzy set, whereas Ã denotes the comparable type-2 fuzzy set. When the latter is done, the resulting type-2 fuzzy set is called a "general type-2 fuzzy set" (to distinguish it from the special interval type-2 fuzzy set). Zadeh didn't stop with type-2 fuzzy sets, because in that 1976 paper he also generalized all of this to type-n fuzzy sets. The present article focuses only on type-2 fuzzy sets because they are the next step in the logical progression from type-1 to type-n fuzzy sets, where n = 1, 2, ... . Although some researchers are beginning to explore higher than type-2 fuzzy sets, as of early 2009, this work is in its infancy. The membership function of a general type-2 fuzzy set, Ã, is three-dimensional (Fig. 1), where the third dimension is the value of the membership function at each point on its two-dimensional domain that is called its "footprint of uncertainty"(FOU). For an interval type-2 fuzzy set that third-dimension value is the same (e.g., 1) everywhere, which means that no new information is contained in the third dimension of an interval type-2 fuzzy set. So, for such a set, the third dimension is ignored, and only the FOU is used to describe it. It is for this reason that an interval type-2 fuzzy set is sometimes called a first-order uncertainty fuzzy set model, whereas a general type-2 fuzzy set (with its useful third-dimension) is sometimes referred to as a second-order uncertainty fuzzy set model. The FOU represents the blurring of a type-1 membership function, and is completely described by its two bounding functions (Fig. 2), a lower membership function (LMF) and an upper membership function (UMF), both of which are type-1 fuzzy sets! Consequently, it is possible to use type-1 fuzzy set mathematics to characterize and work with interval type-2 fuzzy sets. This means that engineers and scientists who already know type-1 fuzzy sets will not have to invest a lot of time learning about general type-2 fuzzy set mathematics in order to understand and use interval type-2 fuzzy sets. Work on type-2 fuzzy sets languished during the 1980s and early-to-mid 1990s, although a small number of articles were published about them. People were still trying to figure out what to do with type-1 fuzzy sets, so even though Zadeh proposed type-2 fuzzy sets in 1976, the time was not right for researchers to drop what they were doing with type-1 fuzzy sets to focus on type-2 fuzzy sets. This changed in the latter part of the 1990s as a result of Jerry Mendel and his student's works on type-2 fuzzy sets and systems. Since then, more researchers around the world are writing articles about type-2 fuzzy sets and systems. == Interval type-2 fuzzy sets == Interval type-2 fuzzy sets have received the most attention because the mathematics that is needed for such sets—primarily Interval arithmetic—is much simpler than the mathematics that is needed for general type-2 fuzzy sets. The literature about interval type-2 fuzzy sets is large, whereas the literature about general type-2 fuzzy sets is much smaller. Both kinds of fuzzy sets are being actively researched by an ever-growing number of researchers around the world and have resulted in successful employment in a variety of domains such as robot control. Formally, the following have already been worked out for interval type-2 fuzzy sets: Fuzzy set operations: union, intersection and complement Centroid (a very widely used operation by practitioners of such sets, and also an important uncertainty measure for them) Other uncertainty measures [fuzziness, cardinality, variance and skewness and uncertainty bounds Similarity Subsethood Embedded fuzzy sets Fuzzy set ranking Fuzzy rule ranking and selection Type-reduction methods Firing intervals for an interval type-2 fuzzy logic system Fuzzy weighted average Linguistic weighted average Synthesizing an FOU from data that are collected from a group of subject == Interval type-2 fuzzy logic systems == Type-2 fuzzy sets are finding very wide applicability in rule-based fuzzy logic systems (FLSs) because they let uncertainties be modeled by them whereas such uncertainties cannot be modeled by type-1 fuzzy sets. A block diagram of a type-2 FLS is depicted in Fig. 3. This kind of FLS is used in fuzzy logic control, fuzzy logic signal processing, rule-based classification, etc., and is sometimes referred to as a function approximation application of fuzzy sets, because the FLS is designed to minimize an error function. The following discussions, about the four components in Fig. 3 rule-based FLS, are given for an interval type-2 FLS, because to-date they are the most popular kind of type-2 FLS; however, most of the discussions are also applicable for a general type-2 FLS. Rules, that are either provided by subject experts or are extracted from numerical data, are expressed as a collection of IF-THEN statements, e.g., IF temperature is moderate and pressure is high, then rotate the valve a bit to the right. Fuzzy sets are associated with the terms that appear in the antecedents (IF-part) or consequents (THEN-part) of rules, and with the inputs to and the outputs of the FLS. Membership functions are used to describe these fuzzy sets, and in a type-1 FLS they are all type-1 fuzzy sets, whereas in an interval type-2 FLS at least one membership function is an interval type-2 fuzzy set. An interval type-2 FLS lets any one or all of the following kinds of uncertainties be quantified: Words that are used in antecedents and consequents of rules—because words can mean different things to different people. Uncertain consequents—because when rules are obtained from a group of experts, consequents will often be different for the same rule, i.e. the experts will not necessarily be in agreement. Membership function parameters—because when those parameters are optimized using uncertain (noisy) training data, the parameters become uncertain. Noisy measurements—because very often it is such measurements that activate the FLS. In Fig. 3, measured (crisp) inputs are first transformed into fuzzy sets in the Fuzzifier block because it is fuzzy sets and not numbers that activate the rules which are described in terms of fuzzy sets and not numbers. Three kinds of fuzzifiers are possible in an interval type-2 FLS. When measurements are: Perfect, they are modeled as a crisp set; Noisy, but the noise is stationary, they are modeled as a type-1 fuzzy set; and, Noisy, but the noise is non-stationary, they are modeled as an interval type-2 fuzzy set (this latter kind of fuzzification cannot be done in a type-1 FLS). In Fig. 3, after measurements are fuzzified, the resulting input fuzzy sets are mapped into fuzzy output sets by the Inference block. This is accomplished by first quantifying each rule using fuzzy set theory, and by then using the mathematics of fuzzy sets to establish the output of each rule, with the help of an inference mechanism. If there are M rules then the fuzzy input sets to the Inference block will activate only a subset of those rules, where the subset contains at least one rule and usually way fewer than M rules. The inference is done one rule at a time. So, at the output of the Inference block, there will be one or more fired-rule fuzzy output sets. In most engineering applications of an FLS, a number (and not a fuzzy set) is needed as its final output, e.g., the consequent of the rule given above is "Rotate the valve a bit to the right." No automatic valve will know what this means because "a bit to the right" is a linguistic expression, and a valv
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MultiValue database

A MultiValue database is a type of NoSQL and multidimensional database. It is typically considered synonymous with PICK, a database originally developed as the Pick operating system. MultiValue databases include commercial products from Rocket Software, Revelation, InterSystems, Northgate Information Solutions, ONgroup, and other companies. These databases differ from a relational database in that they have features that support and encourage the use of attributes which can take a list of values, rather than all attributes being single-valued. They are often categorized with MUMPS within the category of post-relational databases, although the data model actually pre-dates the relational model. Unlike SQL-DBMS tools, most MultiValue databases can be accessed both with or without SQL. == History == Don Nelson designed the MultiValue data model in the early to mid-1960s. Dick Pick, a developer at TRW, worked on the first implementation of this model for the US Army in 1965. Pick considered the software to be in the public domain because it was written for the military, this was but the first dispute regarding MultiValue databases that was addressed by the courts. Ken Simms wrote DataBASIC, sometimes known as S-BASIC, in the mid-1970s. It was based on Dartmouth BASIC, but had enhanced features for data management. Simms played a lot of Star Trek (a text-based early computer game originally written in Dartmouth BASIC) while developing the language, to ensure that DataBASIC functioned to his satisfaction. Three of the implementations of MultiValue - PICK version R77, Microdata Reality 3.x, and Prime Information 1.0 - were very similar. In spite of attempts to standardize, particularly by International Spectrum and the Spectrum Manufacturers Association, who designed a logo for all to use, there are no standards across MultiValue implementations. Subsequently, these flavors diverged, although with some cross-over. These streams of MultiValue database development could be classified as one stemming from PICK R83, one from Microdata Reality, and one from Prime Information. Because of the differences, some implementations have provisions for supporting several flavors of the languages. An attempt to document the similarities and differences can be found at the Post-Relational Database Reference (PRDB). One reasonable hypothesis for this data model lasting 50 years, with new database implementations of the model even in the 21st century is that it provides inexpensive database solutions. == Data model example == In a MultiValue database system: a database or schema is called an "account" a table or collection is called a "file" a column or field is called a field or an "attribute", which is composed of "multi-value attributes" and "sub-value attributes" to store multiple values in the same attribute. a row or document is called a "record" or "item" Data is stored using two separate files: a "file" to store raw data and a "dictionary" to store the format for displaying the raw data. For example, assume there's a file (table) called "PERSON". In this file, there is an attribute called "eMailAddress". The eMailAddress field can store a variable number of email address values in a single record. The list [[email protected], [email protected], [email protected]] can be stored and accessed via a single query when accessing the associated record. Achieving the same (one-to-many) relationship within a traditional relational database system would include creating an additional table to store the variable number of email addresses associated with a single "PERSON" record. However, modern relational database systems support this multi-value data model too. For example, in PostgreSQL, a column can be an array of any base type. == MultiValue Basic Language == Multivalue Basic (now commonly styled as mvBasic) is a family of programming languages more or less common (and portable) to all the multivalue databases derived from the original Pick Operating System. The variations between implementations are known as flavours. The language originates from Dartmouth Basic and the earliest implementation of PickBASIC (now D3 FlashBasic). Over time various customisations and extensions have been added to take advantage of capabilities added to the different flavours while staying mainly in sync. mvBasic statements and functions are designed to access and take advantage of the multivalue database model and providing the usual capabilities of most modern languages. For example, cryptography and communications. mvBasic is typeless and lends itself to structured programming techniques. Example code is available but limited. Whilst there are commercial applications and tools available, the multivalue database community has not embraced the open source library/package model to the degree seen with other languages. The typical mvBasic compiler compiles program source to a P-code executable object and runs in an interpreter, with D3 FlashBasic and jBASE being notable exceptions. == MultiValue Query Language == Known as ENGLISH, ACCESS, AQL, UniQuery, Retrieve, CMQL, and by many other names over the years, corresponding to the different MultiValue implementations, the MultiValue query language differs from SQL in several respects. Each query is issued against a single dictionary within the schema, which could be understood as a virtual file or a portal to the database through which to view the data. LIST PEOPLE LAST_NAME FIRST_NAME EMAIL_ADDRESSES WITH LAST_NAME LIKE "Van..." The above statement would list all e-mail addresses for each person whose last name starts with "Van". A single entry would be output for each person, with multiple lines showing the multiple e-mail addresses (without repeating other data about the person).
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Agents of S.H.I.E.L.D. season 4

The fourth season of the American television series Agents of S.H.I.E.L.D., based on the Marvel Comics spy organization S.H.I.E.L.D., follows Phil Coulson and other S.H.I.E.L.D. agents and allies after the signing of the Sokovia Accords. It is set in the Marvel Cinematic Universe (MCU) and acknowledges the continuity of the franchise's films. The season was produced by ABC Studios, Marvel Television, and Mutant Enemy Productions, with Jed Whedon, Maurissa Tancharoen, and Jeffrey Bell serving as showrunners. Clark Gregg reprises his role as Coulson from the film series, starring alongside the returning series regulars Ming-Na Wen, Chloe Bennet, Iain De Caestecker, Elizabeth Henstridge, and Henry Simmons. They are joined by John Hannah who was promoted from his recurring guest role in the third season. The fourth season was ordered in March 2016, with production taking place from that July until the following April. Due to its broadcast schedule, the season was split into three "pods": Ghost Rider for the first eight episodes, featuring recurring guest star Gabriel Luna as the supernatural Robbie Reyes / Ghost Rider and exploring mysticism in the MCU alongside the film Doctor Strange (2016); LMD, referring to the new Life Model Decoy program, for the next seven episodes which focus on recurring guest star Mallory Jansen as the LMD Aida; and Agents of Hydra for the final seven episodes, partly set in a "what if" virtual reality that allowed the return of former series regular Brett Dalton as Grant Ward. The season is also affected by the events of the film Captain America: Civil War (2016), and continues storylines established in the canceled series Agent Carter. The first episode premiered at a screening on September 19, 2016, with the season then airing for 22 episodes on ABC, from September 20, 2016, until May 16, 2017. The premiere debuted to 3.58 million viewers, down from previous season premieres but average for the series. Critical response to the season was positive, with many feeling that each pod was better than the last and in particular praising the visual effects and tone of Ghost Rider, the writing and acting of LMD, and the character development and political commentary explored during Agents of Hydra. The season saw series low viewership, but was still considered to have solved ABC's problem during its new Tuesday night timeslot, and the series was renewed for a fifth season in May 2017. == Episodes == == Cast and characters == == Production == === Development === Agents of S.H.I.E.L.D. was renewed for a fourth season on March 3, 2016, earlier than usual for the series. Executive producer Jed Whedon said on this, "We're thrilled to know going into the end of [season three] with certainty that we will be returning, because we can build our story accordingly." Executive producer Maurissa Tancharoen also noted that logistics for hiring directors for the season in advance would be easier, "which is a very nice privilege to have...that's a luxury". The end of the episode "What If..." features an onscreen tribute to Bill Paxton, who died in February 2017 and had portrayed John Garrett in the series' first season. The series paid additional tribute to Paxton in "All the Madame's Men" with promos during The Bakshi Report news segment showcasing John Garrett as a fallen American hero. The end of "World's End" features a similar onscreen tribute to Powers Boothe, who died in May 2017 and had portrayed Gideon Malick in the series' third season. === Writing === The season shifted to the later 10 pm timeslot, allowing it to take on a darker, more mature tone than previous seasons. According to Tancharoen, "The whole tagline for this year is 'Agents of S.H.I.E.L.D. After Dark'". The timeslot gave the series the opportunity to present an increased level of violence and partial nudity, as well as take more risks and present edgier themes. Following the third-season finale, Tancharoen stated that the fourth season would explore the guilt Daisy Johnson has over Lincoln Campbell's death. Executive producer Jeffrey Bell noted the writers tried to continue the tradition of "finding new combinations and new conflicts" between different sets of characters, given "a lot of procedurals [see] the same people doing the same thing for five years". Pairings that would be explored included Coulson and Mack, continuing from the end of season three, who have a mutual respect for one another due to their relationships with Daisy, and Leo Fitz and Holden Radcliffe, who work together. The Fitz-Simmons relationship was also explored more, examining the new challenges it presented for the two "working together, loving each other and living together". Following the third season's dealing with the themes of Captain America: Civil War (2016), such as the opposing reactions to the Inhumans, Whedon said that the question of "How do you deal with a war with powered people at that level, a government level?" was one that they wanted to answer in the fourth season. Tancharoen called the Inhumans "a permanent part of our universe now", with Whedon adding, "we have a quick-fire way of introducing people with powers. It gives us a lot of leeway in our world, and it lets us explore the metaphors of what it is like to be different. We will never close that chapter." With the Inhumans film being removed from Marvel Studios' release schedule, the series had "a little more freedom" and were "able to do a little bit more" with the species, including the potential of introducing some of the "classic" Inhumans, though the series would focus less on Inhumans than the third season which saw "a real significant Inhuman agenda story". It was not intended to be a spin-off of Agents of S.H.I.E.L.D. On the evolution of S.H.I.E.L.D. to featuring so many powered characters, Whedon said "the dynamic in the world has changed. There was one person with powers, and then by The Avengers there were maybe six total ... now they're much more prevalent, so there's reaction from the public based on that." The season is structured into three "pods" based on its airing schedule: the first eight episodes, subtitled Ghost Rider; LMD (Life Model Decoy) for the subsequent seven episodes; and a third pod for the final seven episodes called Agents of Hydra. Elements and characters cross over between the different pods, but the sections "definitely have a different feel" from one another, as Bell explained that 22 episodes "is a long time to hold a big bad or a single plot line, especially for an audience", and for the past two seasons, the series was able to have two separated halves that "allows us to introduce a big bad. And then, something happens and we rise somebody new ... Now, there's three of those." "Financial considerations" were also taken into account in creating the pods for the season, as using LMDs does not "cost as much as setting a guy's head on fire via CGI". In terms of writing the "complicated season", Whedon said the writers were "aware that our fans are our fans and have spent some time with these characters and are clever and see things coming sometimes ... Part of our job is to create not just what we are presenting on plot, but letting the audience be one step ahead of us and being one step ahead of that." He added that the writers knew that they wanted to tell a Ghost Rider story, an LMD story, and a "what if" scenario, and the hardest part was making each pod still fit together as a single season. The major connection ultimately became the Darkhold, which leads from the magic of Ghost Rider to the advanced science of LMD and then the Framework in Agents of Hydra. Ghost Rider also reappears in the final episode of the season, "World's End", as an additional connection. ==== Ghost Rider ==== While planning the fourth season, Marvel suggested that the series introduce Ghost Rider, after the character's film rights had returned to Marvel from Sony in May 2013. Loeb felt that this made the season unquestionably "the series' biggest" with the "most ambitious story yet". He added that "one of the things that we talked about is, S.H.I.E.L.D. always looked out for the weird, the unusual, the things that were and could be a problem for the public", and Marvel realized that Ghost Rider's abilities, which are more mystical than anything seen in the series to date, opened up "a quarter of the universe that we haven't really spent a lot of time exploring ... what happens if our very real, our very grounded agents who are very much a family have to take on something that is as bizarre and powerful and unique as Ghost Rider." Bell added that the producers would have been willing to give an entire season of the show to a Ghost Rider arc if the season was 13 episodes or less, but 22 episodes seemed too long to "feel like one flavor". The Robbie Reyes version of Ghost Rider was chosen over other versions of the character from the comics because of his relationship with his brother Gabe, w
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The Fractal Prince

The Fractal Prince is the second science fiction novel by Hannu Rajaniemi and the second novel to feature the post-human gentleman thief Jean le Flambeur. It was published in Britain by Gollancz in September 2012, and by Tor in the same year in the US. The novel is the second in the trilogy, following The Quantum Thief (2010) and preceding The Causal Angel (2014). == Plot summary == After the events of The Quantum Thief, Jean le Flambeur and Mieli are on their way to Earth. Jean is trying to open the Schrödinger's Box he retrieved from the memory palace on the Oubliette. After making little progress, he is prodded by the ship Perhonen to talk to Mieli, who turns out to be possessed by the pellegrini again. This time, Jean identifies Mieli's employer as a Sobornost Founder, Joséphine Pellegrini, and gets her to reveal how he got captured, thereby picking up the clues to make plans for his next heist. No sooner is that done than an attack comes from the Hunter. The ship and crew barely survived that, and Jean realizes that he has to find a better way to open the Box - fast. Mieli has been very quiet after they left Mars. She has given up almost everything to the pellegrini, even her identity, as she has promised to let the pellegrini make gogols of her in exchange for rescuing the thief. Yet, having to work with the thief is testing her, especially when the thief eventually does something even more unforgivable than stealing Sydän's jewel from her. In the city of Sirr, on an Earth ravaged by wildcode, Tawaddud and Dunyazad are sisters and members of the powerful Gomelez family. Tawaddud is the black sheep of the family, having run away from her husband and consorted with a notorious jinn, a disembodied intelligence from the wildcode desert. Now Cassar Gomelez, her father, hopes to get her to curry favor with a gogol merchant, Abu Nuwas, so that he has enough votes in the Council for the upcoming decision to renegotiate the Cry of Wrath Accords with the Sobornost. Soon, Tawaddud is embroiled in an investigation with a Sobornost envoy into the murder that triggered the need for her father to forge a new alliance in the first place, and forced to confront old secrets that will change Sirr forever. Somewhere else, in a bookshop and on a beach, a young boy is at play. His mother has told him not to talk to strangers, but there has never been anyone here before. Until now. Should he talk to them? == Influences == In the acknowledgments, Rajaniemi cites the influence of "Andy Clark, Douglas Hofstadter, Maurice Leblanc, Jan Potocki and [...] The Arabian Nights." === Self-loops === In the novel, the idea that the mind is a self-loop may have been influenced by the theories of the Professor of Philosophy, Andy Clark, and the book I Am a Strange Loop by Douglas Hofstadter. === Frame stories === The novel uses frame stories rather extensively, a feature also of The Arabian Nights and Jan Potocki's The Manuscript Found in Saragossa. Several characters in Sirr are the namesakes of characters in these two earlier works as well. The events in The Quantum Thief are also retold at least once by Jean le Flambeur in the course of the events in this novel. == Reception == The novel has received generally positive reviews. However, criticisms of the novel still revolve around Rajaniemi's uncompromising "show, don't tell" style. For example, Amy Goldschlager, writing for the Los Angeles Review of Books, suggested that "[a] bit more explication of the physics involved (“surfing the deficit angle”?) would really be helpful, more helpful than the description of the Schrödinger’s Cat problem given earlier in the book".
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Emi Kusano

Emi Kusano (Japanese: 草野絵美, Hepburn: Kusano Emi; born August 4, 1990) is a Tokyobased Japanese multidisciplinary artist known for creating photography, video, and installations using generative AI technology. Her work explores themes of nostalgia, pop culture, and collective memory. Her work explores themes of nostalgia, pop culture, and collective memory. She is recognized as one of the early practitioners of generative AI art. Her work has been exhibited at the 21st Century Museum of Contemporary Art, Kanazawa, and screened at the M+ Museum’s Asian Avant-Garde Film Festival. Additionally, she has participated in prestigious international art fairs, including Paris Photo and Art Basel Hong Kong. In 2025, she was named one of the World Economic Forum's Young Global Leaders. In 2026, she was selected as a fellow for the AI x Arts Fellowship at Mohamed bin Zayed University of Artificial Intelligence. Kusano serves as a part-time lecturer at the Tokyo University of the Arts and is the producer and vocalist for the Synthwave music unit, Satellite Young. == Early life == === Photography === Kusano was born and raised in Tokyo. Kusano's career began during her high school years before 2008 when she became involved in street fashion photography. Her photographs, primarily taken in Harajuku, were published on "Japanese Streets", "Metropolis", CNN's travel guide magazine "CNN GO","WGSN". Her photography was exhibited at the FIT Museum in New York and the Victoria and Albert Museum in London. == Career == === Music and Installation work === Since 2014, in collaboration with BelleMaison Sekine, Kusano has led "Satellite Young," a synthwave music unit s the lead vocalist, she sings about blending 1980s idol culture with lyrics that tackle contemporary issues such as planned obsolescence ("Sony Timer"), online dating, artificial intelligence, and social media. Their music, known for its conceptual depth, has earned international niche recognition. "Satellite Young" has participated in music festivals, including "South by Southwest," showcasing their unique fusion of retro aesthetics and modern critiques. In 2018, she was selected to participate in "Art Hack Day," an interdisciplinary art hackathon held at The National Museum of Emerging Science and Innovation. where she presented "Singing Dream," a karaoke machine endowed with artificial life, earning the Jury Prize. "Instababy Generator," a 2019 installation co-created with Junichi Yamaoka, explored the concept of designer babies and received recognition at the SIGGRAPH Art Gallery. In October 2020, operating under the name Emi Satellite, she debuted as a solo singer with her first single "Glass Ceiling," an empowerment anthem that addresses the challenges faced by women and encourages progress towards the future. The music video for this song features a direction where strong women rewrite the roles of protagonists in a Bishōjo game, a type of dating simulation game. This concept later served as a prototype for Shinsei Galverse. === Challenge for Blockchain Art === In 2021, she explored the financial world through her single "IPO" and entered the NFT space with "Love Is an IPO," her first NFT work on Ethereum, sold on Foundation. In April 2022, she co-founded the crowdfunded anime project "Shinsei Galverse" with Ayaka Ohira, Devin Mancuso, and Jack Baldwin. serving as one of the executive directors overseeing the creative direction and story. The project's NFT collection of 8,888 ranked #1 on OpenSea's "Top NFTs" for several days, marking one of Japan's first globally successful blockchain art projects. In 2023, Shinsei Galverse produced the official "I like u" music video by Grammy-nominated singer Tove Lo as an initial anime endeavor. Kusano also contributed to discussions on Web3.0 and blockchain technology as a panelist in seminars organized by the Digital Agency of Japan. === AI art === In May 2023, Kusano's first AI art collection "Neural Fad" depicting imaginary fashion history sold out 100 pieces within 24 hours at the "Bright Moments Tokyo" In June, she created WWDJAPAN's first AI-generated magazine cover using her own face. It is the first AI cover in Japanese fashion media. She was also appointed t to the Cultural Affairs Agency's Copyright Subcommittee, she participates in discussions on generative AI and copyright. Her "Synthetic Reflections" self-portrait series debuted on SuperRare, with the first piece auctioned for 3.5 ETH (equivalent to 6,480 US dollars at the time). In July 2023, she co-exhibited a 3D AI-generated dress at Christie's "Future Frequencies" auction with Gucci, alongside Claire Silver. In September, her 30-piece "Pixelated Perception" exhibit at Art Blocks Marfa explored 1990s media and gender, also showcased at the 21st Century Museum of Contemporary Art, Kanazawa. In December, her "Techno-Animism" AI art collection fused Japanese animism with technology. Collaborating with a U.S. gallery, she unveiled 336 pieces during a two-week Art Basel world tour. Throughout the two-week tour, she sold a total of 336 pieces, generating 11.2 ETH (equivalent to 21,264 US dollars at the time). === Generative art === In February 2024, the generative art platform Art Blocks selected the work "Melancholic Magical Maiden," for its Curated category. This piece reconstructs the aesthetics of 1990s magical girl anime, offering a critique of past anime heroines. It sold out within an hour, with all 300 pieces going for a total of 57 ETH (equivalent to approximately 215,385US dollars at the time). In April 2024, Emi Kusano spoke at the Standing Committee on Copyright and Other Rights at the World Intellectual Property Organization (WIPO) in Geneva, Switzerland, where she presented AI-specific information for discussion. == Style and technique == Kusano draws inspiration from Japanese retro-futurism as a foundation for her artwork, which explores the cutting-edge of technology. This approach is fueled by nostalgia for the pre-internet era, specifically the postwar period when Japanese mass media held significant sway. By blending modern technology with retro-culture, she captures the complex feelings of love, hate, and ambivalence towards present and future accelerationism. While at university, Kusano was profoundly influenced by Naoki Sakai, the industrial designer responsible for igniting the retro-futurism movement. In her musical project "Satellite Young", Kusano dons the persona of an '80s female idol and sings about contemporary technology. In her installation piece "Singing Dream", she investigates the concept of an artificial life form inhabiting a karaoke machine, which has been popular since the 1980s, compelling people to sing. In the collaborative NFT art project "Shinsei Galverse", Kusano reimagines a cyberpunk anime primarily featuring female characters, incorporating elements of magical girls popular in the early Heisei period. == Personal life == Kusano has two sons. In August 2021, she minted her older son Zombie Zoo Keeper's pixel art on "OpenSea" as part of his summer research project. The artwork was purchased by notable figures including Brud CEO Trevor McFedries and Steve Aoki, who bought the piece for the equivalent of 21.82 thousand US dollars, highlighting the intersection of art, technology, and family in her work.
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Discovery system (artificial intelligence)

A discovery system is an artificial intelligence system that attempts to discover new scientific concepts or laws. The aim of discovery systems is to automate scientific data analysis and the scientific discovery process. Ideally, an artificial intelligence system should be able to search systematically through the space of all possible hypotheses and yield the hypothesis - or set of equally likely hypotheses - that best describes the complex patterns in data. During the era known as the second AI summer (approximately 1978–1987), various systems akin to the era's dominant expert systems were developed to tackle the problem of extracting scientific hypotheses from data, with or without interacting with a human scientist. These systems included Autoclass, Automated Mathematician, Eurisko, which aimed at general-purpose hypothesis discovery, and more specific systems such as Dalton, which uncovers molecular properties from data. The dream of building systems that discover scientific hypotheses was pushed to the background with the second AI winter and the subsequent resurgence of subsymbolic methods such as neural networks. Subsymbolic methods emphasize prediction over explanation, and yield models which works well but are difficult or impossible to explain which has earned them the name black box AI. A black-box model cannot be considered a scientific hypothesis, and this development has even led some researchers to suggest that the traditional aim of science - to uncover hypotheses and theories about the structure of reality - is obsolete. Other researchers disagree and argue that subsymbolic methods are useful in many cases, just not for generating scientific theories. == Discovery systems from the 1970s and 1980s == Autoclass was a Bayesian Classification System written in 1986 Automated Mathematician was one of the earliest successful discovery systems. It was written in 1977 and worked by generating a modifying small Lisp programs Eurisko was a Sequel to Automated Mathematician written in 1984 Dalton is a still maintained program capable of calculating various molecular properties initially launched in 1983 and available in open source since 2017 Glauber is a scientific discovery method written in the context of computational philosophy of science launched in 1983 == Modern discovery systems (2009–present) == After a couple of decades with little interest in discovery systems, the interest in using AI to uncover natural laws and scientific explanations was renewed by the work of Michael Schmidt, then a PhD student in Computational Biology at Cornell University. Schmidt and his advisor, Hod Lipson, invented Eureqa, which they described as a symbolic regression approach to "distilling free-form natural laws from experimental data". This work effectively demonstrated that symbolic regression was a promising way forward for AI-driven scientific discovery. Since 2009, symbolic regression has matured further, and today, various commercial and open source systems are actively used in scientific research. Notable examples include Eureqa, now a part of DataRobot AI Cloud Platform, AI Feynman, and QLattice.
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Tempos Modernos

Tempos Modernos (English: Modern Times) is a Brazilian telenovela produced and broadcast by TV Globo. It premiered on 11 January 2010, replacing Caras & Bocas, and ended on 16 July 2010, replaced by Ti Ti Ti. The series is written by Bosco Brasil, with the collaboration of Izabel de Oliveira, Maria Elisa Berredo, Mário Teixeira and Patrícia Moretzsohn. It stars Fernanda Vasconcellos, Thiago Rodrigues, Antônio Fagundes, and Eliane Giardini. Priscila Fantin, Danton Mello, Marcos Caruso, Regiane Alves, Vivianne Pasmanter, Otávio Muller, Felipe Camargo, and Malu Galli also star in main roles. == Cast == Fernanda Vasconcellos as Cornélia Cordeiro Santos Reis "Nelinha" Thiago Rodrigues as José Carlos Pimenta Cordeiro "Zeca" Antônio Fagundes as Leal Cordeiro Eliane Giardini as Hélia Pimenta Priscila Fantin as Nara Nolasco Marcos Caruso as Otto Niemann Vivianne Pasmanter as Regiane Cordeiro Mourão Regiane Alves as Goretti Cordeiro Bodanski "Gô" Otávio Muller as Altemir Assunção da Paz Bodanski (Bodanski) Felipe Camargo as Vinícius Porto de Mello "Portinho" Danton Mello as Renato Vieira de Mattos Alessandra Maestrini as Benedita Kusnezov Piñon "Dita'" Leonardo Medeiros as Ramon Piñon Guilherme Weber as Albano Mourão Grazi Massafera as Deodora Madureira Niemann / N. Anne Malu Galli as Iolanda Paranhos Guilherme Leicam as Led Piñon Aline Peixoto as Jannis Piñon Caroline Abras as Katrina João Baldasserini as Túlio Osório Débora Duarte as Tertuliana "Tertu" Otávio Augusto as Faustaço Lumbriga Selma Egrei as Tamara Palumbo Genézio de Barros as Pasquale Paula Possani as Maureen Lobianco Ricardo Blat as Fidélio Pascoal da Conceição as Zuppo Tuna Dwek as Justine Jairo Mattos as Gaulês "Jean Paul" Luciana Borghi as Bárbara Lee Cris Vianna as Tita Bicalho Edmilson Barros as Lindomar Mariano Assunção Cláudia Missura as Lavínia Palumbo Victor Pecoraro as Ricardo Maurício "Maurição" Naruna Costa as Dolores Damasceno Antônio Fragoso as Zapata Fabrício Boliveira as Nabuco Mota Eliana Pittman as Miranda Paranhos Márcio Seixas as Frankenstein "Frank" (voice) Joana Lerner as Heloísa "Helô" Darlan Cunha as João Carlos Paranhos "Joca" Janaína Ávila as Milena Morgado Anderson Lau as Okuda Alexandra Martins as Dulcinólia Lumbriga "Duba" Paulo Leal de Melo as Raulzão "Ducha Fria" Cássio Inácio as Tartana Gilberto Miranda as Madrugadinha Rafa Martins as Max do Cavaco Isabel Lobo as Thaís Trancoso Alexandre Cioletti as Valvênio Xandy Britto as Nelsinho Pallotti Polliana Aleixo as Maria Eunice Cordeiro Bodanski Ana Karolina Lannes as Maria Eugênia Cordeiro Bodanski Rebeca Orestein as Maria Helena Cordeiro Bodanski Jenifer de Oliveira Andrade as Maria Clara Cordeiro Bodanski
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Science Fiction Thinking Machines

Science Fiction Thinking Machines: Robots, Androids, Computers is an anthology of science fiction short stories edited by American anthologist Groff Conklin. It was first published in hardcover by Vanguard Press in May 1954. An abridged paperback edition titled, Selections from Science Fiction Thinking Machines was later published by Bantam Books in August 1955 and was reprinted in September 1964. The book consists of twenty-two novelettes and short stories by various science fiction authors, together with an introduction and bibliography by the editor. The stories were previously published from 1899-1954, in various science fiction and other magazines. == Contents == Note: stories also appearing in the abridged edition annotated A. "Introduction" (Groff Conklin) "Automata: I" (S. Fowler Wright) "Moxon's Master" (Ambrose Bierce) "Robbie" (Isaac Asimov) A "The Scarab" (Raymond Z. Gallun) "The Mechanical Bride" (Fritz Leiber) "Virtuoso" (Herbert Goldstone) A "Automata: II" (S. Fowler Wright) "Boomerang" (Eric Frank Russell) A "The Jester" (William Tenn) A "R. U. R." (Karel Čapek) "Skirmish" (Clifford D. Simak) A "Soldier Boy" (Michael Shaara) "Automata: III" (S. Fowler Wright) "Men Are Different" (Alan Bloch) A "Letter to Ellen" (Chan Davis) A "Sculptors of Life" (Wallace West) "The Golden Egg" (Theodore Sturgeon) A "Dead End" (Wallace Macfarlane) A "Answer" (Hal Clement) "Sam Hall" (Poul Anderson) A "Dumb Waiter" (Walter M. Miller Jr.) A "Problem for Emmy" (Robert Sherman Townes) A "Selected List of Tales About Robots, Androids, and Computers" (Groff Conklin)
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Resistance Database Initiative

HIV Resistance Response Database Initiative (RDI) was formed in 2002 to use artificial intelligence (AI) to predict how patients will respond to HIV drugs using data from more 250,000 patients from around 50 countries around the world. The RDI used its models to power its HIV Treatment Response Prediction System (HIV-TRePS). Launched in 2010, this free online tool enabled healthcare professionals to upload their patient’s data and obtain highly accurate predictions of how they would respond to different combinations of the 30 or more drugs available. The tool enabled physicians to individualize their patients’ treatment, using these predictions based on more than a million patient-years of treatment experience. HIV-TRePS was possibly the first ever AI-based system for medical decision-making to be developed, successfully tested, and used in clinical practice. It has since been used by thousands of healthcare professionals to optimise the treatment of tens of thousands of patients. Since the RDI’s inception the treatment of HIV infection has progressed enormously, with more effective and better tolerated drugs available in ever more convenient combination formulations. In most countries HIV is now considered a chronic, manageable condition. Moreover, the success of the drugs in reducing the amount of virus is substantially reducing the onward transmission of the virus and cases of new infections are falling in many settings. This improvement in HIV treatment means the need for sophisticated AI to support HIV treatment decisions has significantly reduced. In response, the RDI ceased development of further models and, in March 2024, withdrew its HIV-TRePS system. == Background == Human immunodeficiency virus (HIV) is the virus that causes acquired immunodeficiency syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. There are approximately 30 HIV antiretroviral drugs that have been approved for the treatment of HIV infection, from six different classes, based on the point in the HIV life-cycle at which they act. They are used in combination; typically 3 or more drugs from 2 or more different classes, a form of therapy known as highly active antiretroviral therapy (HAART). The aim of therapy is to suppress the virus to very low, ideally undetectable, levels in the blood. This prevents the virus from depleting the immune cells that it preferentially attacks CD4 cells and prevents or delays illness and death. Despite the expanding availability of these drugs and the impact of their use, treatments continue to fail, often involving to the development of resistance. During drug therapy, low-level virus replication may still occur, particularly when a patient misses a dose. HIV makes errors in copying its genetic material and, if a mutation makes the virus resistant to one or more of the drugs in the patient's treatment, it may begin to replicate more successfully in the presence of that drug and undermine the effect of the treatment. If this happens, the treatment needs to be changed to re-establish control over the virus. == RDI's Approach == The RDI’s approach was to use artificial intelligence (including neural network and random forest models), trained with data from hundreds of thousands of patients, treated with different drugs in a variety of clinical settings all over the world, to predict how an individual patient will respond to any new combination of HIV drugs. The models were tested with independent data sets and consistently achieved accuracy of approximately 80%.
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Windows Live OneCare Safety Scanner

Windows Live OneCare Safety Scanner (formerly Windows Live Safety Center and codenamed Vegas) was an online scanning, PC cleanup, and diagnosis service to help remove of viruses, spyware/adware, and other malware. It was a free web service that was part of Windows Live. On November 18, 2008, Microsoft announced the discontinuation of Windows Live OneCare, offering users a new free anti-malware suite Microsoft Security Essentials, which had been available since the second half of 2009. However, Windows Live OneCare Safety Scanner, under the same branding as Windows Live OneCare, was not discontinued during that time. The service was officially discontinued on April 15, 2011 and replaced with Microsoft Safety Scanner. == Overview == Windows Live OneCare Safety Scanner offered a free online scanning and protection from threats. The Windows Live OneCare Safety Scanner must be downloaded and installed to your computer to scan your computer. The "Full Service Scan" looks for common PC health issues such as viruses, temporary files, and open network ports. It searches and removes viruses, improves a computer's performance, and removes unnecessary clutter on the PC's hard disk. The user can choose between a "Full Scan" (which can be customized) or a "Quick Scan". The "Full Scan" scans for viruses (comprehensive scan or quick scan), hard disk performance (Disk fragmentation scan and/or Desk cleanup scan) and network safety (open port scan). The "Quick Scan" only scans for viruses, only on specific areas on the computer. The quick scan is faster than the full scan, hence that appellation. The service also provides a virus database, information about online threats, and general computer security documentation and tools. == Limits == The virus scanner on the Windows Live OneCare Safety Scanner site runs a scan of the user's computer only when the site is visited. It does not run periodic scans of the system, and does not provide features to prevent viruses from infecting the computer at the time, or thereafter. It simply resolves detected infections. Many users who have posted on the Product Feedback forum report script errors relating to Internet Explorer 7 (besides IE being the only browser supported by this service). The OneCare safety scanner team have been actively solving these problems, many of them registry-related.
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They're Made Out of Meat

"They're Made Out of Meat" is a short story by American writer Terry Bisson. It was originally published in OMNI. It consists entirely of dialogue between two characters. Bisson's website hosts a theatrical adaptation. A film adaptation won the Grand Prize at the Seattle Science Fiction Museum's 2006 film festival. The story was collected in the 1993 anthology Bears Discover Fire and Other Stories, and has circulated widely on the Internet, which Bisson found "flattering". It has been quoted in cognitive, cosmological, and philosophical scholarship. == Plot == The two characters are intelligent beings capable of traveling faster than light, on a mission to "contact, welcome and log in any and all sentient races or multibeings in this quadrant of the Universe." Bisson's stage directions represent them as "two lights moving like fireflies among the stars" on a projection screen. One of them tells the incredulous other about the recent discovery of carbon-based lifeforms "made up entirely of meat". After conversing briefly about it, they both deem such beings and communication with them too bizarre and agree to "erase the records and forget the whole thing", marking the Solar System "unoccupied". == Film adaptations == === They're Made out of Meat (2005) === In 2005, Stephen O'Regan wrote and directed a live film adaptation starring Tom Noonan and Ben Bailey. The film was made as a final project for the New York Film Academy. The main action takes place inside a diner full of teenagers in Staten Island, New York. The music for the film was scored by Bob Reynolds. === They're Made out of Meat (2010) === Jeff Frumess and Trevor Scott produced a version in 2010. They added the character of a homeless conspiracy theorist with an original score by musician Sam Belkin. The film was shot at Hartsdale station in Westchester County, New York. === Meat (2021) === Masha Maksimova developed a version in Cinemiracle format, a triple split-screen process, as a student project at the Berlin University of Applied Sciences in the communication design course. The dialogue is conducted by two telepathic humanoid aliens and the thoughts are visualised by found-footage collages.
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Resistance Database Initiative

HIV Resistance Response Database Initiative (RDI) was formed in 2002 to use artificial intelligence (AI) to predict how patients will respond to HIV drugs using data from more 250,000 patients from around 50 countries around the world. The RDI used its models to power its HIV Treatment Response Prediction System (HIV-TRePS). Launched in 2010, this free online tool enabled healthcare professionals to upload their patient’s data and obtain highly accurate predictions of how they would respond to different combinations of the 30 or more drugs available. The tool enabled physicians to individualize their patients’ treatment, using these predictions based on more than a million patient-years of treatment experience. HIV-TRePS was possibly the first ever AI-based system for medical decision-making to be developed, successfully tested, and used in clinical practice. It has since been used by thousands of healthcare professionals to optimise the treatment of tens of thousands of patients. Since the RDI’s inception the treatment of HIV infection has progressed enormously, with more effective and better tolerated drugs available in ever more convenient combination formulations. In most countries HIV is now considered a chronic, manageable condition. Moreover, the success of the drugs in reducing the amount of virus is substantially reducing the onward transmission of the virus and cases of new infections are falling in many settings. This improvement in HIV treatment means the need for sophisticated AI to support HIV treatment decisions has significantly reduced. In response, the RDI ceased development of further models and, in March 2024, withdrew its HIV-TRePS system. == Background == Human immunodeficiency virus (HIV) is the virus that causes acquired immunodeficiency syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. There are approximately 30 HIV antiretroviral drugs that have been approved for the treatment of HIV infection, from six different classes, based on the point in the HIV life-cycle at which they act. They are used in combination; typically 3 or more drugs from 2 or more different classes, a form of therapy known as highly active antiretroviral therapy (HAART). The aim of therapy is to suppress the virus to very low, ideally undetectable, levels in the blood. This prevents the virus from depleting the immune cells that it preferentially attacks CD4 cells and prevents or delays illness and death. Despite the expanding availability of these drugs and the impact of their use, treatments continue to fail, often involving to the development of resistance. During drug therapy, low-level virus replication may still occur, particularly when a patient misses a dose. HIV makes errors in copying its genetic material and, if a mutation makes the virus resistant to one or more of the drugs in the patient's treatment, it may begin to replicate more successfully in the presence of that drug and undermine the effect of the treatment. If this happens, the treatment needs to be changed to re-establish control over the virus. == RDI's Approach == The RDI’s approach was to use artificial intelligence (including neural network and random forest models), trained with data from hundreds of thousands of patients, treated with different drugs in a variety of clinical settings all over the world, to predict how an individual patient will respond to any new combination of HIV drugs. The models were tested with independent data sets and consistently achieved accuracy of approximately 80%.
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