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Biohybrid system
Biohybrid systems refer to the integration of biological materials, such as cells or tissues, with artificial components, including electronics or mechanical structure. This combination incorporates the capabilities of living organisms with the precision of man-made technology. As a result, these systems perform tasks that neither biology nor machines could achieve independently. Biohybrid systems might use lab-cultured muscle cells to power small robots or combine sensors with living tissue for better health sensing. The intent behind these systems is to combine the benefits of biological and technological components to introduce new solutions for complex medical challenges. Biohybrid systems may have transformative potential across sectors, such as robotics to create actuators and sensors that mimic natural muscle and nerve function, medicine in developing smart implants and drug delivery systems, in prosthetics for enhancing user control through neural or muscular interfaces and environmental sustainability for deploying biohybrid solutions for pollution sensing or remediation. == Origin == The term "biohybrid" is a compound of "bio" from biology (meaning life) and "hybrid" (referring to a combination of distinct elements), denoting a field of study. Its use helps distinguish such systems from purely biological constructs or entirely synthetic machines. Early academic mentions may include bio actuated robotics papers and foundational tissue-robot integration studies published in journals like Nature Biotechnology or Science Robotics. The emergence of the term reflects a growing recognition of the need to describe systems that do not fit cleanly into traditional categories. == Design principles == One of the most significant biohybrid challenges is to engineer interfaces between living tissue and artificial materials that are efficient. This means having precise control over adhesion at the surface, diffusion of nutrients, and signal conduction. Actuation mechanisms within the heart of these systems generate movement or mechanical response. These may be in the form of living muscle cells such as skeletal myocytes or cardiomyocytes, soft pneumatic actuators, or electrical stimulation-responsive tissues. Materials selection is equally critical. Hydrogels, elastomers like PDMS (polydimethylsiloxane), and biopolymers are commonly used due to their softness and biocompatibility. These materials must support cell viability, resist immune attack, and allow the integration of mechanical or electrical components. == Key components == At their core, biohybrid systems work by bridging living biological parts with technology. Through this integration, functionality that neither system could accomplish singularly is possible. Biological parts may be cells, tissues, or even organs—occasionally cultured in a laboratory setting. These biological parts carry out biologically inspired behaviors, such as muscle contraction or chemical sensing in the body. Technological components may constitute devices like sensors, electronic components, and mechanical structure. These manipulate the system, supply power, or transfer data. An example is a sensor that is implantable within a body and detects glucose levels as it sends information to a smart phone. By integrating these artificial and biological parts, biohybrid systems can perform advanced functions, such as tissue regeneration, real-time health monitoring, or the recovery of motor function in paralysis patients. Biohybrid systems generally consist of two major components: the biological and the mechanical. Biological components may include muscle cells for contraction, endothelial cells for vascularization, and stem cells for regenerative capabilities. Mechanical components comprise soft actuators that mimic organic motion, synthetic scaffolds that provide support and structure, and microfluidic systems that facilitate the delivery of nutrients and removal of waste. These components are combined in a manner that allows for dynamic, lifelike behavior—such as the contraction of tissue or the propagation of mechanical waves—while maintaining biocompatibility and durability. == Applications == The range of applications for biohybrid systems is broad and continuously expanding. In robotics, biohybrid structures have been used to engineer microscopic, muscle-driven machines, such as Harvard University's biohybrid stingray robot. In medical applications, they offer new alternatives for organ repair and augmentation, including biohybrid heart valves and esophageal scaffolds. Biohybrids are also promising in neural interfaces, where the goal is to create long-lasting, stable interaction between mechanical devices and brain tissue. Muscle-actuated drug response platforms are under exploration in pharmacology for modelling and real-time screening. == Examples == Several high-profile research projects have demonstrated the potential of biohybrid systems: Harvard researchers developed a biohybrid swimming ray powered by rat cardiac cells layered onto a gold skeleton, mimicking the motion of a real stingray. At the Massachusetts Institute of Technology, a cardiac pump actuated entirely by living heart muscle cells was engineered to simulate the behavior of a beating heart. Bio actuated soft robots have been built to simulate gut peristalsis, using muscle contractions to replicate natural wave-like movement in the digestive tract. == Challenges and limitations == As with many technologies that involve living systems, biohybrid systems raise important ethical and biomedical questions. Cell sourcing remains a key issue, particularly when embryonic or animal-derived cells are used. Long-term viability is another concern—living tissues must be kept alive with nutrients and oxygen, and they often degrade or elicit immune responses when implanted. Powering these biological parts presents logistical and ethical hurdles as well. Systems must either include internal mechanisms for nutrient delivery or be supported externally, which can limit portability and independence. == Future directions == Researchers are exploring self-directed, self-regulated organ substitutes and regenerative implants that can respond to their surroundings in real-time. These systems may be integrated with artificial intelligence to make them adjust to stimuli and coordinate complex behaviors. Future potential applications are wearable biohybrid systems for rehabilitation, space medicine devices for long-duration missions, and implantable devices that integrate into human physiology.
Babak Hodjat
Babak Hodjat (Persian: بابک حجت; born November 1, 1967) is a British computer scientist, entrepreneur, and writer. He was the co-founder and CEO of Sentient Technologies and now holds the position of Chief Technology Officer AI at Cognizant. He is a specialist in the field of artificial intelligence and machine learning. In 1998 Hodjat co-founded Dejima Inc and served as CEO and CTO, his patented work on artificial intelligence led to the technology used by Apple for their digital assistant Siri. == Biography == === Early life === Babak Hodjat was born on November 1, 1967, in Wimbledon. His father was a retired university professor in entomology who worked at the British Museum. As a child, he did not like insects and would wander off to the nearby science museum, where he would spend long hours in front of a computer they had on display. He attended middle school in the United States. He studied at the Sharif University of Technology from 1986 to 1995, and received his Master of Science degree in software engineering. In 1994, together with another computer department student Hormoz Shahrzad presented their research titled Introducing a dynamic problem solving scheme based on a learning algorithm in artificial life environments at the first IEEE Conference on Computational Intelligence held at Orlando. Hodjat received a PhD in machine intelligence from Kyushu University in 2003 During his time there, he published several works on adaptive agent oriented software architecture and natural language user interfaces. === Career in science and business === Hodjat moved to Silicon Valley, California in 1998 and founded Dejima Inc. (named after the historic Japanese Dejima artificial island). The firm was based on a patented adaptive agent-oriented software engineering platform developed by Hodjat, Christopher Savoie and Makoto Amamiya. Hodjat served as the CTO and as the CEO for 9 months from October 2000. By 2000 the company had offices in San Jose, London and Tokyo. In 2002, the company developed a voice control Natural Interaction Platform (NPI) in collaboration with the Stanford University's research group Archimedes Project. During these years Hodjat continued his research on agent oriented software architecture and natural language user interfaces. In July 2003, Dejima got funding from SRI International within the Cognitive Assistant that Learns and Organizes (CALO) project of DARPA and worked on a Perceptive Assistant that Learns (PAL) initiative. Hodjat was the primary inventor of the firm's agent-oriented technology applied to intelligent interfaces for mobile and enterprise computing – a technology that eventually led to Siri. In April 2004, Dejima was acquired by Sybase iAnywhere. Hodjat served as senior director of engineering at Sybase iAnywhere from 2004 to 2008, where he developed AvantGo Platform, mBusiness Anywhere, and Answers Anywhere. In 2006, he co-founded MobileVerbs Inc., a mobile marketing service company, which was acquired by iLoop Mobile in February 2010. In 2007, he teamed with Antoine Blondeau (former CEO of Dejima) and Adam Cheyer (Dejima's vice president and Chief Architect of the CALO project) to establish Genetic Finance Holding Ltd. (where he began as CTO). In 2014 the firm became Sentient Technologies. Hodjat was joined by his long-time research fellow Hormoz Shahrzad who became principal scientist, while Hodjat held the position of chief scientist. In the following years Hodjat has worked on developing massively distributed computing technology and improving machine-learning technique known as evolutionary algorithms. One area that gained special attention from the press was applying Sentient Technologies algorithms to a stock market trading through specially created Sentient Investment Management hedge fund. Following the management change within Sentient Technologies, Hodjat became the company's CEO in February 2017. He continues his business and educational projects (he was on the jury of IBM Watson AI XPRIZE and the Merit Awards committee for the ISAL Award). == Writing == Hodjat is the author of multiple books such as The Konar and the Apple: Fun, Beauty, and Dread--From Ahwaz to California and the science fiction novel "The Narrator" (January 2022; ISBN 978-1-7354860-1-7)(March 2023; ISBN 978-1-7354860-0-0). == Selected publications == Hodjat, B.; Shahrzad, H. (1994). "Introducing a dynamic problem solving scheme based on a learning algorithm in artificial life environments". IEEE International Joint Conference on neural networks (IJCNN-94). Vol. 4. IEEE International Joint Conference on neural networks. pp. 2333–2338. doi:10.1109/ICNN.1994.374583. ISBN 978-0-7803-1901-1. S2CID 60497133. Hodjat, B.; Savoie, C.J.; Amamiya, M. (2006) [1998]. "An adaptive agent oriented software architecture". PRICAI'98: Topics in Artificial Intelligence. Springer. pp. 33–46. arXiv:cs/9812014. doi:10.1007/BFb0095256. ISBN 978-3-540-49461-4. S2CID 5317786. Hodjat, B.; Amamiya, M. (2000-05-25). "Applying the Adaptive Agent Oriented Software Architecture to the Parsing of Context Sensitive Grammars". IEICE Transactions on Information and Systems. E83-D (5): 1142–1152. ISSN 0916-8532. Retrieved 2017-12-14. Hodjat, Babak; Hodjat, Siamak; Treadgold, Nick; Jonsson, Ing-Marie (2006). "CRUSE: a context reactive natural language mobile interface". Proceedings of the 2nd annual international workshop on Wireless internet. WICON. doi:10.1145/1234161.1234181. ISBN 978-1-59593-510-6. S2CID 2388254. O'Reilly, Una-May; Wagy, Mark; Hodjat, Babak (2013). "Chapter 6: EC-Star: A Massive-Scale, Hub and Spoke, Distributed Genetic Programming System". In Riolo, R.; Vladislavleva, E.; Ritchie, M.; Moore, J.H. (eds.). Genetic Programming Theory and Practice X. Springer-Verlag New York. pp. 73–85. doi:10.1007/978-1-4614-6846-2. ISBN 978-1-4614-6845-5. S2CID 39650969. Retrieved 2017-12-14. Hodjat, Babak; Hemberg, Erik; Shahrzad, Hormoz; O'Reilly, Una-May (2014). "Chapter 4: Maintenance of a Long Running Distributed Genetic Programming System for Solving Problems Requiring Big Data". In Riolo, Rick; Moore, Jason H.; Kotanchek, Mark (eds.). Genetic Programming Theory and Practice XI. Springer-Verlag New York. pp. 65–83. doi:10.1007/978-1-4939-0375-7. ISBN 978-1-4939-0374-0. S2CID 28843739. Retrieved 2017-12-14. Shahrzad, Hormoz; Hodjat, Babak; Miikkulainen, Risto (2016). "Estimating the Advantage of Age-Layering in Evolutionary Algorithms". Proceedings of the Genetic and Evolutionary Computation Conference 2016. Genetic and Evolutionary Computation Conference. pp. 693–699. doi:10.1145/2908812.2908911. ISBN 978-1-4503-4206-3. S2CID 215516530. == Patents == Babak Hodjat holds 21 patents in the fields of agent-oriented programming, natural language decision engines, distributed evolutionary algorithms for asset management and trading and data mining.
Dissociated press
Dissociated press is a parody generator (a computer program that generates nonsensical text). The generated text is based on another text using the Markov chain technique. The name is a play on "Associated Press" and the psychological term dissociation (although word salad is more typical of conditions like aphasia and schizophrenia – which is, however, frequently confused with dissociative identity disorder by laypeople). An implementation of the algorithm is available in Emacs. Another implementation is available as a Perl module in CPAN, Games::Dissociate. == The algorithm == The algorithm starts by printing a number of consecutive words (or letters) from the source text. Then it searches the source text for an occurrence of the few last words or letters printed out so far. If multiple occurrences are found, it picks a random one, and proceeds with printing the text following the chosen occurrence. After a predetermined length of text is printed out, the search procedure is repeated for the newly printed ending. Considering that words and phrases tend to appear in specific grammatical contexts, the resulting text usually seems correct grammatically, and if the source text is uniform in style, the result appears to be of similar style and subject, and takes some effort on the reader's side to recognize as not genuine. Still, the randomness of the assembly process deprives it of any logical flow - the loosely related parts are connected in a nonsensical way, creating a humorously abstract, random result. == Examples == Here is a short example of word-based Dissociated Press applied to the Jargon File: wart: n. A small, crocky feature that sticks out of an array (C has no checks for this). This is relatively benign and easy to spot if the phrase is bent so as to be not worth paying attention to the medium in question. Here is a short example of letter-based Dissociated Press applied to the same source: window sysIWYG: n. A bit was named aften /bee´t@/ prefer to use the other guy's re, especially in every cast a chuckle on neithout getting into useful informash speech makes removing a featuring a move or usage actual abstractionsidered interj. Indeed spectace logic or problem! == History == The dissociated press algorithm is described in HAKMEM (1972) Item #176. The name "dissociated press" is first known to have been associated with the Emacs implementation. Brian Hayes discussed a Travesty algorithm in Scientific American in November 1983. The article provided a garbled William Faulkner passage: When he got on the table, he come in. He never come out of my own pocket as a measure of protecting the company against riot and bloodshed. And when he said. "You tell me a bus ticket, let alone write out no case histories. Then the law come back with a knife!" Hugh Kenner and Joseph O'Rourke of Johns Hopkins University discussed their frequency table-based Travesty generator for microcomputers in BYTE in November 1984. The article included the Turbo Pascal source for two versions of the generator, one using Hayes' algorithm and another using Claude Shannon's Hellbat algorithm. Murray Lesser offered a compiled BASIC version in the magazine in July 1985, in September 1985 Peter Wayner offered a version that used tree data structures instead of frequency tables, and in December 1985 Neil J. Rubenking offered a version written in Turbo Pascal that stored frequency information in a B-tree.
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Document classification
Document classification or document categorization is a problem in library science, information science and computer science. The task is to assign a document to one or more classes or categories. This may be done "manually" (or "intellectually") or algorithmically. The intellectual classification of documents has mostly been the province of library science, while the algorithmic classification of documents is mainly in information science and computer science. The problems are overlapping, however, and there is therefore interdisciplinary research on document classification. The documents to be classified may be texts, images, music, etc. Each kind of document possesses its special classification problems. When not otherwise specified, text classification is implied. Documents may be classified according to their subjects or according to other attributes (such as document type, author, printing year etc.). In the rest of this article only subject classification is considered. There are two main philosophies of subject classification of documents: the content-based approach and the request-based approach. == "Content-based" versus "request-based" classification == Content-based classification is classification in which the weight given to particular subjects in a document determines the class to which the document is assigned. It is, for example, a common rule for classification in libraries, that at least 20% of the content of a book should be about the class to which the book is assigned. In automatic classification it could be the number of times given words appears in a document. Request-oriented classification (or -indexing) is classification in which the anticipated request from users is influencing how documents are being classified. The classifier asks themself: “Under which descriptors should this entity be found?” and “think of all the possible queries and decide for which ones the entity at hand is relevant” (Soergel, 1985, p. 230). Request-oriented classification may be classification that is targeted towards a particular audience or user group. For example, a library or a database for feminist studies may classify/index documents differently when compared to a historical library. It is probably better, however, to understand request-oriented classification as policy-based classification: The classification is done according to some ideals and reflects the purpose of the library or database doing the classification. In this way it is not necessarily a kind of classification or indexing based on user studies. Only if empirical data about use or users are applied should request-oriented classification be regarded as a user-based approach. == Classification versus indexing == Sometimes a distinction is made between assigning documents to classes ("classification") versus assigning subjects to documents ("subject indexing") but as Frederick Wilfrid Lancaster has argued, this distinction is not fruitful. "These terminological distinctions,” he writes, “are quite meaningless and only serve to cause confusion” (Lancaster, 2003, p. 21). The view that this distinction is purely superficial is also supported by the fact that a classification system may be transformed into a thesaurus and vice versa (cf., Aitchison, 1986, 2004; Broughton, 2008; Riesthuis & Bliedung, 1991). Therefore, assigning a subject term to a document in an index is equivalent to assigning that document to the class of documents indexed by that term (all documents indexed or classified as X belong to the same class of documents). == Automatic document classification (ADC) == Automatic document classification tasks can be divided into three sorts: supervised document classification where some external mechanism (such as human feedback) provides information on the correct classification for documents, unsupervised document classification (also known as document clustering), where the classification must be done entirely without reference to external information, and semi-supervised document classification, where parts of the documents are labeled by the external mechanism. There are several software products under various license models available. === Techniques === Automatic document classification techniques include: Artificial neural network Concept Mining Decision trees such as ID3 or C4.5 Expectation maximization (EM) Instantaneously trained neural networks Latent semantic indexing Multiple-instance learning Naive Bayes classifier Natural language processing approaches Rough set-based classifier Soft set-based classifier Support vector machines (SVM) K-nearest neighbour algorithms tf–idf == Applications == Classification techniques have been applied to spam filtering, a process which tries to discern E-mail spam messages from legitimate emails email routing, sending an email sent to a general address to a specific address or mailbox depending on topic language identification, automatically determining the language of a text genre classification, automatically determining the genre of a text readability assessment, automatically determining the degree of readability of a text, either to find suitable materials for different age groups or reader types or as part of a larger text simplification system sentiment analysis, determining the attitude of a speaker or a writer with respect to some topic or the overall contextual polarity of a document. health-related classification using social media in public health surveillance article triage, selecting articles that are relevant for manual literature curation, for example as is being done as the first step to generate manually curated annotation databases in biology
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