Biohybrid systems refer to the integration of biological materials, such as cells or tissues, with artificial components, including electronics or mechanical structure. This combination incorporates the capabilities of living organisms with the precision of man-made technology. As a result, these systems perform tasks that neither biology nor machines could achieve independently. Biohybrid systems might use lab-cultured muscle cells to power small robots or combine sensors with living tissue for better health sensing. The intent behind these systems is to combine the benefits of biological and technological components to introduce new solutions for complex medical challenges. Biohybrid systems may have transformative potential across sectors, such as robotics to create actuators and sensors that mimic natural muscle and nerve function, medicine in developing smart implants and drug delivery systems, in prosthetics for enhancing user control through neural or muscular interfaces and environmental sustainability for deploying biohybrid solutions for pollution sensing or remediation. == Origin == The term "biohybrid" is a compound of "bio" from biology (meaning life) and "hybrid" (referring to a combination of distinct elements), denoting a field of study. Its use helps distinguish such systems from purely biological constructs or entirely synthetic machines. Early academic mentions may include bio actuated robotics papers and foundational tissue-robot integration studies published in journals like Nature Biotechnology or Science Robotics. The emergence of the term reflects a growing recognition of the need to describe systems that do not fit cleanly into traditional categories. == Design principles == One of the most significant biohybrid challenges is to engineer interfaces between living tissue and artificial materials that are efficient. This means having precise control over adhesion at the surface, diffusion of nutrients, and signal conduction. Actuation mechanisms within the heart of these systems generate movement or mechanical response. These may be in the form of living muscle cells such as skeletal myocytes or cardiomyocytes, soft pneumatic actuators, or electrical stimulation-responsive tissues. Materials selection is equally critical. Hydrogels, elastomers like PDMS (polydimethylsiloxane), and biopolymers are commonly used due to their softness and biocompatibility. These materials must support cell viability, resist immune attack, and allow the integration of mechanical or electrical components. == Key components == At their core, biohybrid systems work by bridging living biological parts with technology. Through this integration, functionality that neither system could accomplish singularly is possible. Biological parts may be cells, tissues, or even organs—occasionally cultured in a laboratory setting. These biological parts carry out biologically inspired behaviors, such as muscle contraction or chemical sensing in the body. Technological components may constitute devices like sensors, electronic components, and mechanical structure. These manipulate the system, supply power, or transfer data. An example is a sensor that is implantable within a body and detects glucose levels as it sends information to a smart phone. By integrating these artificial and biological parts, biohybrid systems can perform advanced functions, such as tissue regeneration, real-time health monitoring, or the recovery of motor function in paralysis patients. Biohybrid systems generally consist of two major components: the biological and the mechanical. Biological components may include muscle cells for contraction, endothelial cells for vascularization, and stem cells for regenerative capabilities. Mechanical components comprise soft actuators that mimic organic motion, synthetic scaffolds that provide support and structure, and microfluidic systems that facilitate the delivery of nutrients and removal of waste. These components are combined in a manner that allows for dynamic, lifelike behavior—such as the contraction of tissue or the propagation of mechanical waves—while maintaining biocompatibility and durability. == Applications == The range of applications for biohybrid systems is broad and continuously expanding. In robotics, biohybrid structures have been used to engineer microscopic, muscle-driven machines, such as Harvard University's biohybrid stingray robot. In medical applications, they offer new alternatives for organ repair and augmentation, including biohybrid heart valves and esophageal scaffolds. Biohybrids are also promising in neural interfaces, where the goal is to create long-lasting, stable interaction between mechanical devices and brain tissue. Muscle-actuated drug response platforms are under exploration in pharmacology for modelling and real-time screening. == Examples == Several high-profile research projects have demonstrated the potential of biohybrid systems: Harvard researchers developed a biohybrid swimming ray powered by rat cardiac cells layered onto a gold skeleton, mimicking the motion of a real stingray. At the Massachusetts Institute of Technology, a cardiac pump actuated entirely by living heart muscle cells was engineered to simulate the behavior of a beating heart. Bio actuated soft robots have been built to simulate gut peristalsis, using muscle contractions to replicate natural wave-like movement in the digestive tract. == Challenges and limitations == As with many technologies that involve living systems, biohybrid systems raise important ethical and biomedical questions. Cell sourcing remains a key issue, particularly when embryonic or animal-derived cells are used. Long-term viability is another concern—living tissues must be kept alive with nutrients and oxygen, and they often degrade or elicit immune responses when implanted. Powering these biological parts presents logistical and ethical hurdles as well. Systems must either include internal mechanisms for nutrient delivery or be supported externally, which can limit portability and independence. == Future directions == Researchers are exploring self-directed, self-regulated organ substitutes and regenerative implants that can respond to their surroundings in real-time. These systems may be integrated with artificial intelligence to make them adjust to stimuli and coordinate complex behaviors. Future potential applications are wearable biohybrid systems for rehabilitation, space medicine devices for long-duration missions, and implantable devices that integrate into human physiology.
Flexidraw
Flexidraw is a 1985 graphics computer program published by Inkwell Systems. == Gameplay == Flexidraw is a graphics program that allows users to produce drawings using a light pen and print them. == Reception == Roy Wagner reviewed the product for Computer Gaming World, and stated that "Of the many graphics programs available Flexidraw is certainly the best supported by it's [sic] parent company."
Oriented energy filters
Oriented energy filters are used to grant sight to intelligent machines and sensors. The light comes in and is filtered so that it can be properly computed and analyzed by the computer allowing it to “perceive” what it is measuring. These energy measurements are then calculated to take a real time measurement of the oriented space time structure. 3D Gaussian filters are used to extract orientation measurements. They were chosen due to their ability to capture a broad spectrum and easy and efficient computations. The use of these vision systems can then be used in smart room, human interface and surveillance applications. The computations used can tell more than the standalone frame that most perceived motion devices such as a television frame. The objects captured by these devices would tell the velocity and energy of an object and its direction in relation to space and time. This also allows for better tracking ability and recognition.
Google AI Studio
Google AI Studio is a web-based integrated development environment developed by Google for prototyping applications using generative AI models. Released in December 2023 alongside the Gemini API, the platform provides access to Google's Gemini family of models and related tools for image, video, and audio generation. The service targets both developers and non-technical users for testing prompts and generating code for the Gemini API. == History == Google launched AI Studio on December 13, 2023, as the successor to Google MakerSuite. MakerSuite, introduced at Google I/O in May 2023, had provided similar functionality for Google's PaLM language models. The AI Studio was launched alongside the public release of the Gemini API. == Features == AI Studio's interface consists of a central prompt area and a settings panel for model selection and parameter adjustment. The platform supports chat prompts for multi-turn conversations and includes system instructions for defining model behavior, tone, or specific rules. Users can employ zero-shot and few-shot prompting techniques to guide the model's output format. The platform processes various media types including video, audio, and documents, and can generate images through Imagen models, videos through Veo models, and audio through text-to-speech functionality. Additional tools include real-time streaming for screen sharing and live analysis, code execution in a sandboxed Python environment, grounding with Google Search for current information, URL context for analyzing specific web pages, and a thinking mode for complex reasoning tasks. == Available models == The platform provides access to several Google AI models including the Gemini language models, Imagen for image generation, Veo for video generation, LearnLM for educational applications, and Gemma, Google's open-source model family. == Privacy and data usage == Google AI Studio's data handling differs between free and paid users. For free tier users, Google uses submitted prompts, uploaded files, and generated responses to improve its products and services, with human reviewers potentially reading and annotating the data after disconnection from user accounts. Google advises against submitting sensitive information on the free tier. Users who enable Google Cloud Billing are considered paid service users, and their data is not used for product improvement. Data is processed according to Google's Data Processing Addendum and retained temporarily for abuse monitoring. == Availability == The platform is available at no cost, with API usage subject to a free tier with daily and per-minute rate limits. Access is restricted to users aged 18 and older in specific countries and territories. The service was initially unavailable in the United Kingdom and European Economic Area due to regulatory concerns, which drew user complaints. == Reception == Reviews have noted the platform's accessibility and integration with Gemini models, with features such as real-time screen sharing and large context windows cited as notable capabilities. However, reviewers have raised concerns about the privacy implications for free tier users, whose data is used for model training. Some users have reported inconsistent performance with features like screen streaming and issues with folder uploads for large datasets. The initial geographic restrictions were a point of criticism among developers in affected regions.
Data analysis for fraud detection
Fraud represents a significant problem for governments and businesses and specialized analysis techniques for discovering fraud using them are required. Some of these methods include knowledge discovery in databases (KDD), data mining, machine learning and statistics. They offer applicable and successful solutions in different areas of electronic fraud crimes. In general, the primary reason to use data analytics techniques is to tackle fraud since many internal control systems have serious weaknesses. For example, the currently prevailing approach employed by many law enforcement agencies to detect companies involved in potential cases of fraud consists in receiving circumstantial evidence or complaints from whistleblowers. As a result, a large number of fraud cases remain undetected and unprosecuted. In order to effectively test, detect, validate, correct error and monitor control systems against fraudulent activities, businesses entities and organizations rely on specialized data analytics techniques such as data mining, data matching, the sounds like function, regression analysis, clustering analysis, and gap analysis. Techniques used for fraud detection fall into two primary classes: statistical techniques and artificial intelligence. == Statistical techniques == Examples of statistical data analysis techniques are: Data preprocessing techniques for detection, validation, error correction, and filling up of missing or incorrect data. Calculation of various statistical parameters such as averages, quantiles, performance metrics, probability distributions, and so on. For example, the averages may include average length of call, average number of calls per month and average delays in bill payment. Models and probability distributions of various business activities either in terms of various parameters or probability distributions. Computing user profiles. Time-series analysis of time-dependent data. Clustering and classification to find patterns and associations among groups of data. Data matching Data matching is used to compare two sets of collected data. The process can be performed based on algorithms or programmed loops. Trying to match sets of data against each other or comparing complex data types. Data matching is used to remove duplicate records and identify links between two data sets for marketing, security or other uses. Sounds like Function is used to find values that sound similar. The Phonetic similarity is one way to locate possible duplicate values, or inconsistent spelling in manually entered data. The ‘sounds like’ function converts the comparison strings to four-character American Soundex codes, which are based on the first letter, and the first three consonants after the first letter, in each string. Regression analysis allows you to examine the relationship between two or more variables of interest. Regression analysis estimates relationships between independent variables and a dependent variable. This method can be used to help understand and identify relationships among variables and predict actual results. Gap analysis is used to determine whether business requirements are being met, if not, what are the steps that should be taken to meet successfully. Matching algorithms to detect anomalies in the behavior of transactions or users as compared to previously known models and profiles. Techniques are also needed to eliminate false alarms, estimate risks, and predict future of current transactions or users. Some forensic accountants specialize in forensic analytics which is the procurement and analysis of electronic data to reconstruct, detect, or otherwise support a claim of financial fraud. The main steps in forensic analytics are data collection, data preparation, data analysis, and reporting. For example, forensic analytics may be used to review an employee's purchasing card activity to assess whether any of the purchases were diverted or divertible for personal use. == Artificial intelligence == Fraud detection is a knowledge-intensive activity. The main AI techniques used for fraud detection include: Data mining to classify, cluster, and segment the data and automatically find associations and rules in the data that may signify interesting patterns, including those related to fraud. Expert systems to encode expertise for detecting fraud in the form of rules. Pattern recognition to detect approximate classes, clusters, or patterns of suspicious behavior either automatically (unsupervised) or to match given inputs. Machine learning techniques to automatically identify characteristics of fraud. Neural nets to independently generate classification, clustering, generalization, and forecasting that can then be compared against conclusions raised in internal audits or formal financial documents such as 10-Q. Other techniques such as link analysis, Bayesian networks, decision theory, and sequence matching are also used for fraud detection. A new and novel technique called System properties approach has also been employed where ever rank data is available. Statistical analysis of research data is the most comprehensive method for determining if data fraud exists. Data fraud as defined by the Office of Research Integrity (ORI) includes fabrication, falsification and plagiarism. == Machine learning and data mining == Early data analysis techniques were oriented toward extracting quantitative and statistical data characteristics. These techniques facilitate useful data interpretations and can help to get better insights into the processes behind the data. Although the traditional data analysis techniques can indirectly lead us to knowledge, it is still created by human analysts. To go beyond, a data analysis system has to be equipped with a substantial amount of background knowledge, and be able to perform reasoning tasks involving that knowledge and the data provided. In effort to meet this goal, researchers have turned to ideas from the machine learning field. This is a natural source of ideas, since the machine learning task can be described as turning background knowledge and examples (input) into knowledge (output). If data mining results in discovering meaningful patterns, data turns into information. Information or patterns that are novel, valid and potentially useful are not merely information, but knowledge. One speaks of discovering knowledge, before hidden in the huge amount of data, but now revealed. The machine learning and artificial intelligence solutions may be classified into two categories: 'supervised' and 'unsupervised' learning. These methods seek for accounts, customers, suppliers, etc. that behave 'unusually' in order to output suspicion scores, rules or visual anomalies, depending on the method. Whether supervised or unsupervised methods are used, note that the output gives us only an indication of fraud likelihood. No stand alone statistical analysis can assure that a particular object is a fraudulent one, but they can identify them with very high degrees of accuracy. As a result, effective collaboration between machine learning model and human analysts is vital to the success of fraud detection applications. === Supervised learning === In supervised learning, a random sub-sample of all records is taken and manually classified as either 'fraudulent' or 'non-fraudulent' (task can be decomposed on more classes to meet algorithm requirements). Relatively rare events such as fraud may need to be over sampled to get a big enough sample size. These manually classified records are then used to train a supervised machine learning algorithm. After building a model using this training data, the algorithm should be able to classify new records as either fraudulent or non-fraudulent. Supervised neural networks, fuzzy neural nets, and combinations of neural nets and rules, have been extensively explored and used for detecting fraud in mobile phone networks and financial statement fraud. Bayesian learning neural network is implemented for credit card fraud detection, telecommunications fraud, auto claim fraud detection, and medical insurance fraud. Hybrid knowledge/statistical-based systems, where expert knowledge is integrated with statistical power, use a series of data mining techniques for the purpose of detecting cellular clone fraud. Specifically, a rule-learning program to uncover indicators of fraudulent behaviour from a large database of customer transactions is implemented. Cahill et al. (2000) design a fraud signature, based on data of fraudulent calls, to detect telecommunications fraud. For scoring a call for fraud its probability under the account signature is compared to its probability under a fraud signature. The fraud signature is updated sequentially, enabling event-driven fraud detection. Link analysis comprehends a different approach. It relates known fraudsters to other individuals, using record linkage and social network methods. This type of detection is only able to detect fra
Security type system
In computer science, a type system can be described as a syntactic framework which contains a set of rules that are used to assign a type property (int, boolean, char etc.) to various components of a computer program, such as variables or functions. A security type system works in a similar way, only with a main focus on the security of the computer program, through information flow control. Thus, the various components of the program are assigned security types, or labels. The aim of a such system is to ultimately be able to verify that a given program conforms to the type system rules and satisfies non-interference. Security type systems is one of many security techniques used in the field of language-based security, and is tightly connected to information flow and information flow policies. In simple terms, a security type system can be used to detect if there exists any kind of violation of confidentiality or integrity in a program, i.e. the programmer wants to detect if the program is in line with the information flow policy or not. == A simple information flow policy == Suppose there are two users, A and B. In a program, the following security classes (SC) are introduced: SC = {∅, {A}, {B}, {A,B}}, where ∅ is the empty set. The information flow policy should define the direction that information is allowed to flow, which is dependent on whether the policy allows read or write operations. This example considers read operations (confidentiality). The following flows are allowed: → = {({A}, {A}), ({B}, {B}), ({A,B}, {A,B}), ({A,B}, {A}), ({A,B}, {B}), ({A}, ∅), ({B}, ∅), ({A,B}, ∅)} This can also be described as a superset (⊇). In words: information is allowed to flow towards stricter levels of confidentiality. The combination operator (⊕) can express how security classes can perform read operations with respect to other security classes. For example: {A} ⊕ {A,B} = {A} — the only security class that can read from both {A} and {A,B} is {A}. {A} ⊕ {B} = ∅ — neither {A} nor {B} are allowed to read from both {A} and {B}. This can also be described as an intersection (∩) between security classes. An information flow policy can be illustrated as a Hasse diagram. The policy should also be a lattice, that is, it has a greatest lower-bound and least upper-bound (there always exists a combination between security classes). In the case of integrity, information will flow in the opposite direction, thus the policy will be inverted. == Information flow policy in security type systems == Once the policy is in place, the software developer can apply the security classes to the program components. Use of a security type system is usually combined with a compiler that can perform the verification of the information flow according to the type system rules. For the sake of simplicity, a very simple computer program, together with the information flow policy as described in the previous section, can be used as a demonstration. The simple program is given in the following pseudocode: if y{A} = 1 then x{A,B} := 0 else x{A,B} := 1 Here, an equality check is made on a variable y that is assigned the security class {A}. A variable x with a lower security class ({A,B}) is influenced by this check. This means that information is leaking from class {A} to class {A,B}, which is a violation of the confidentiality policy. This leak should be detected by the security type system. === Example === Designing a security type system requires a function (also known as a security environment) that creates a mapping from variables to security types, or classes. This function can be called Γ, such that Γ(x) = τ, where x is a variable and τ is the security class, or type. Security classes are assigned (also called "judgement") to program components, using the following notation: Types are assigned to read operations by: Γ ⊢ e : τ. Types are assigned to write operations by: Γ ⊢ S : τ cmd. Constants can be assigned any type. The following bottom-up notation can be used to decompose the program: assumption1 ... assumptionn/conclusion. Once the program is decomposed into trivial judgements, by which the type can easily be determined, the types for the less trivial parts of the program can be derived. Each "numerator" is considered in isolation, looking at the type of each statement to see if an allowed type can be derived for the "denominator", based on the defined type system "rules". ==== Rules ==== The main part of the security type system is the rules. They say how the program should be decomposed and how type verification should be performed. This toy program consists of a conditional test and two possible variable assignments. Rules for these two events are defined as follows: Applying this to the simple program introduced above yields: The type system detects the policy violation in line 2, where a read operation of security class {A} is performed, followed by two write operations of a less strict security class {A,B}. In more formalized terms, {A} ⋢ {A,B}, {A,B} (from the rule of the conditional test). Thus, the program is classified as "not typeable". === Soundness === The soundness of a security type system can be informally defined as: If program P is well typed, P satisfies non-interference. Volpano, Smith and Irvine were the first to prove soundness of a security type system for a deterministic imperative programming language with a standard (non-instrumented) semantics using the notion of non-interference.
TuVox
TuVox is a company that produces VXML-based telephone speech-recognition applications to replace DTMF touch-tone systems for their clients. == History == TuVox was founded in 2001 by Steven S. Pollock and Ashok Khosla, formerly of Apple Computer Corporation and Claris Corporation. Since then, TuVox has grown to over 150 employees and has US offices in Cupertino, California and Boca Raton, Florida as well as international offices in London, Vancouver and Sydney. In 2005, TuVox acquired the customers and hosting facilities of Net-By-Tel. In 2007, the company raised $20m for its speech recognition, and phone menu software. On July 22, 2010, West Interactive — a subsidiary of West Corporation — announced its acquisition of TuVox. == Customers == TuVox clients include: 1-800-Flowers.com, AMC Entertainment, American Airlines, British Airways, M&T Bank, Canon Inc., Gateway, Inc., Motorola, Progress Energy Inc., Telecom New Zealand, Time, Inc., BECU, Virgin America and USAA.