Artificial reproduction

Artificial reproduction is the re-creation of life brought about by means other than natural ones. It is new life built by human plans and projects. Examples include artificial selection, artificial insemination, in vitro fertilization, artificial womb, artificial cloning, and kinematic replication. Artificial reproduction is one aspect of artificial life. Artificial reproduction can be categorized into one of two classes according to its capacity to be self-sufficient: non-assisted reproductive technology and assisted reproductive technology. Cutting plants' stems and placing them in compost is a form of assisted artificial reproduction, xenobots are an example of a more autonomous type of reproduction, while the artificial womb presented in the movie the Matrix illustrates a non assisted hypothetical technology. The idea of artificial reproduction has led to various technologies. == Theology == Humans have aspired to create life since immemorial times. Most theologies and religions have conceived this possibility as exclusive of deities. Christian religions consider the possibility of artificial reproduction, in most cases, as heretical and sinful. == Philosophy == Although ancient Greek philosophy raised the concept that man could imitate the creative capacity of nature, classic Greeks thought that if possible, human beings would reproduce things as nature does, and vice versa, nature would do the things that man does in the same way. Aristotle, for example, wrote that if nature made tables, it would make them just as men do. In other words, Aristotle said that if nature were to create a table, such table will look like a human-made table. Correspondingly, Descartes envisioned the human body, and nature, as a machine. Cartesian philosophy does not stop seeing a perfect mirror between nature and the artificial. However, Kant revolutionized this old idea by criticizing such naturalism. Kant pedagogically wrote: "Reason, in order to be taught by nature, must approach nature with its principles in one hand, according to which the agreement among appearances can count as laws, and, in the other hand, the experiment thought out in accord with these principles—in order to be instructed by nature not like a pupil, who has recited to him whatever the teacher wants to say, but like an appointed judge who compels witnesses to answer the questions he puts to them.". Humans are not instructed by nature but rather use nature as raw material to invent. Humans find alternatives to the natural restrictions imposed by natural laws thus, nature is not necessarily mirrored. In accordance with Kant (and contrary to what Aristotle thought) Karl Marx, Alfred Whitehead, Jaques Derrida and Juan David García Bacca noticed that nature is incapable of reproducing tables; or airplanes, or submarines, or computers. If nature tried to create airplanes, it would produce birds. If nature tried to create submarines, it would get fishes. If nature tried to create computers, brains would grow. And if nature tried to create man, modern man, monkeys will be evolved. According to Whitehead, if we look for something natural in artificial life, in the most elaborate cases, if anything, only atoms remain natural. Juan David Garcia Bacca summarized, “It will not come out from wood, it will not be born, a galley; from clay, a vessel; from linen, a dress; from iron, a lever,...From natural, artificial. In the artificial, the natural is reduced to a simple raw material, even though it is perfectly specified with natural specification. The artificial is the real, positive, and original negation of the natural: of species, of genus and of essence. Thus, its ontology is superior to natural ontology. And for this very reason Marx did not attach any importance to Darwin, whose evolutionism is confined to the natural order: to changes, at most, from variety to variety, from species to species... natural. For the same reason, nature has no dialectics, even though continuous evolution and selection can occur. The dialectic cannot emerge from the natural, for deeper reasons than, using today's terms, from a bird, an airplane cannot emerge; from fish, a submarine; from ears, a telephone; from eyes, a television; from a brain, a digital computer; from feet, a car; from hands, an engine; from Euclid, Descartes; from Aristotle, Newton; from Plato, Marx.” According to García Bacca, the major difference between natural causes and artificial causes is that nature does not have plans and projects, while humans design things following plans and projects. In contrast, other influential authors such as Michael Behe have depicted the concept and promoted the idea of intelligent design, a notion that has aroused several doubts and heated controversies, as it reframe natural causes in accordance with a natural plan. Previous ideas that have also provided a positive 'sense' to natural reproduction, are orthogenesis, syntropy, orgone and morphic resonance, among others. Although, these ideas have been historically marginalized and often called pseudoscience, recently Bio-semioticians are reconsidering some of them under symbolic approaches. Current metaphysics of science actually recognizes that the artificial ways of reproduction are diverse from nature, i.e., unnatural, anti-natural or supernatural. Because Biosemiotics does not focus on the function of life but on its meaning, it has a better understanding of the artificial than classic biology. == Science == Biology, being the study of cellular life, addresses reproduction in terms of growth and cellular division (i.e., binary fission, mitosis and meiosis); however, the science of artificial reproduction is not restricted by the mirroring of these natural processes.The science of artificial reproduction is actually transcending the natural forms, and natural rules, of reproduction. For example, xenobots have redefined the classical conception of reproduction. Although xenobots are made of eukariotic cells they do not reproduce by mitosis, but rather by kinematic replication. Such constructive replication does not involve growing but rather building. == Assisted reproductive technologies == Assisted reproductive technology (ART)'s purpose is to assist the development of a human embryo, commonly because of medical concerns due to fertility limitations. == Non-assisted reproductive technologies == Non-assisted reproductive technologies (NART) could have medical motivations but are mostly driven by a wider heterotopic ambition. Although, NARTs are initially designed by humans, they are programed to become independent of humans to a relative or absolute extent. James Lovelock proposed that such novelties could overcome humans. === Artificial cloning === Cloning is the cellular reproductive processes where two or more genetically identical organisms are created, either by natural or artificial means. Artificial cloning normally involves editing the genetic code, somatic cell nuclear transfer and 3D bioprinting. === Non-assisted artificial womb === A non-assisted artificial womb or artificial uterus is a device that allow for ectogenesis or extracorporeal pregnancy by growing an embryonic form outside the body of an organism (that would normally carry the embryo to term) without any human assistance. The aspect of non-assistance is the key distinction between the current artificial womb technology (AWT) in modern medical research, which still relies on human assistance. With this non-assisted hypothetical technology, a zygote or stem cells are used to create an embryo that is then incubated and monitored by artificial intelligence (AI) within a chamber composed of biocompatible material. The AI maintains the necessary conditions for the embryo to develop and thrive, proceeding to mimic organic labor and childbirth in order to best help the embryo adjust to the outside world. Ectogenesis—gestation, depicted in the science fiction movie The Matrix, is a fast approaching reality. This type of innovation presupposes that vertebrate wombs are not the only way for bearing humans or other similar forms of life. === Kinematic replication === Self-replication without binary fission, meiosis, mitosis (or any other form of cellular reproduction that involves division and growing) can be achieved. Xenobots are an example of kinematic replication. They are biobots, named after the African clawed frog (Xenopus laevis). Xenobots are cellular life forms designed by using artificial intelligence to build more of themselves by combining frog cells in a liquid medium. The term kinematic replication is usually reserved for biomolecules (e.g. DNA, RNA, prions, etc.) and artificially designed cellular forms (e.g. xenobots). === Machine constructive replication === Machine constructive replication mimics human traditional manufacturing but is entirely self-automated. Such constructive replication is a more general form of kinematic replication, which does not necessarily

Symbol level

In knowledge-based systems, agents choose actions based on the principle of rationality to move closer to a desired goal. The agent is able to make decisions based on knowledge it has about the world (see knowledge level). But for the agent to actually change its state, it must use whatever means it has available. This level of description for the agent's behavior is the symbol level. The term was coined by Allen Newell in 1982. For example, in a computer program, the knowledge level consists of the information contained in its data structures that it uses to perform certain actions. The symbol level consists of the program's algorithms, the data structures themselves, and so on.

Dynamic Graphics Project

The Dynamic Graphics Project (commonly referred to as DGP) is an interdisciplinary research laboratory at the University of Toronto devoted to projects involving computer graphics, computer vision, human computer interaction, and visualization. The lab began as the computer graphics research group of Department of Computer Science Professor Leslie Mezei in 1967. Mezei invited Bill Buxton, a pioneer of human–computer interaction (HCI) to join. In 1972, Ronald Baecker, another HCI pioneer joined, establishing DGP as the first Canadian university group focused on computer graphics and human-computer interaction. According to csrankings.org, the DGP is the top research institution in the world for the combined subfields of computer graphics, HCI, and visualization. Since then, DGP has hosted many well known faculty and students in computer graphics, computer vision and HCI (e.g., Alain Fournier, Bill Reeves, Jos Stam, Demetri Terzopoulos, Marilyn Tremaine). DGP also occasionally hosts artists in residence (e.g., Oscar-winner Chris Landreth). Many past and current researchers at Autodesk (and before that Alias Wavefront) graduated after working at DGP. DGP is located in the St. George campus of University of Toronto in the Bahen Centre for Information Technology. DGP researchers regularly publish at ACM SIGGRAPH, ACM SIGCHI and ICCV. DGP hosts the Toronto User Experience (TUX) Speaker Series and the Sanders Series Lectures. == Notable alumni == Bill Buxton (MS 1978) James McCrae (PhD 2013) Dimitris Metaxas (PhD 1992) Bill Reeves (MS 1976, Ph.D. 1980) Jos Stam (MS 1991, Ph.D. 1995)

List of chatbots

A chatbot is a software application or web interface that is designed to mimic human conversation through text or voice interactions. Modern chatbots are typically online and use generative artificial intelligence systems that are capable of maintaining a conversation with a user in natural language and simulating the way a human would behave as a conversational partner. Such chatbots often use large language models (LLMs) and natural language processing, but simpler chatbots have existed for decades. == LLM chatbots == == General chatbots == == Historical chatbots ==

MegaHAL

MegaHAL is a computer conversation simulator, or "chatterbot", created by Jason Hutchens. == Background == In 1996, Jason Hutchens entered the Loebner Prize Contest with HeX, a chatterbot based on ELIZA. HeX won the competition that year and took the $2000 prize for having the highest overall score. In 1998, Hutchens again entered the Loebner Prize Contest with his new program, MegaHAL. MegaHAL made its debut in the 1998 Loebner Prize Contest. Like many chatterbots, the intent is for MegaHAL to appear as a human fluent in a natural language. As a user types sentences into MegaHAL, MegaHAL will respond with sentences that are sometimes coherent and at other times complete gibberish. MegaHAL learns as the conversation progresses, remembering new words and sentence structures. It will even learn new ways to substitute words or phrases for other words or phrases. Many would consider conversation simulators like MegaHAL to be a primitive form of artificial intelligence. However, MegaHAL doesn't understand the conversation or even the sentence structure. It generates its conversation based on sequential and mathematical relationships. In the world of conversation simulators, MegaHAL is based on relatively old technology and could be considered primitive. However, its popularity has grown due to its humorous nature; it has been known to respond with twisted or nonsensical statements that are often amusing. == Theory of Operation == MegaHal is based at least in part on a so-called "hidden Markov Model", so that the first thing that Megahal does when it "trains" on a script or text is to build a database of text fragments encompassing every possible subset of perhaps 4, 5, or even 6 consecutive words, so that for example - if MegaHal trains on the Declaration of Independence, then MegaHal will build a database containing text fragments such as "When in the course", "in the course of", "the course of human", "course of human events", "of human events, one", "human events, one people", and so on. Then if Megahal is fed another text, such has "Superman, Yes! It's Superman - he can change the course of mighty rivers, bend steel with his bare hands - and who disguised at Clark Kent …" IT MIGHT induce Megahal to apparently bemuse itself to proffer whether Superman can change the course of human events, or something else altogether - such as some rambling about "when in the course of mighty rivers", and so on. Thus likewise - if a phrase like "the White house said" comes up a lot in some text; then Megahal's ability to switch randomly between different contexts which otherwise share some similarity can result at times in some surprising lucidity, or else it might otherwise seem quite bizarre. == Examples == There are some sentences that MegaHAL generated: CHESS IS A FUN SPORT, WHEN PLAYED WITH SHOT GUNS. and COWS FLY LIKE CLOUDS BUT THEY ARE NEVER COMPLETELY SUCCESSFUL. == Distribution == MegaHAL is distributed under the Unlicense. Its source code can be downloaded from the Github repository.

Wetware computer

A wetware computer is an organic computer (which can also be known as an artificial organic brain or a neurocomputer) composed of organic material "wetware" such as "living" neurons. Wetware computers composed of neurons are different than conventional computers because they use biological materials, and offer the possibility of substantially more energy-efficient computing. While a wetware computer is still largely conceptual, there has been limited success with construction and prototyping, which has acted as a proof of the concept's realistic application to computing in the future. The most notable prototypes have stemmed from the research completed by biological engineer William Ditto during his time at the Georgia Institute of Technology. His work constructing a simple neurocomputer capable of basic addition from leech neurons in 1999 was a significant discovery for the concept. This research was a primary example driving interest in creating these artificially constructed, but still organic brains. == Origins and theoretical foundations == The term wetware came from cyberpunk fiction, notably through Gibson's Neuromancer, but was quickly taken up in scientific literature to explain computation by biological material. Theories of early biological computation borrowed from Alan Turing's morphogenesis model, which showed that chemical interactions could produce complex patterns without centralized control. Hopfield's associative memory networks also provided a foundation for biological information systems with fault tolerance and self-organization. == Major characteristics and processes == Biological wetware systems demonstrate dynamic reconfigurability underpinned by neuroplasticity and enable continuous learning and adaptation. Reaction-diffusion-based computing and molecular logic gates allow spatially parallel information processing unachievable in conventional systems. These systems also show fault tolerance and self-repair at the cellular and network level. The development of cerebral organoids—miniature lab-grown brains—demonstrates spontaneous learning behavior and suggests biological tissue as a viable computational substrate. == Overview == The concept of wetware is an application of specific interest to the field of computer manufacturing. Moore's law, which states that the number of transistors which can be placed on a silicon chip is doubled roughly every two years, has acted as a goal for the industry for decades, but as the size of computers continues to decrease, the ability to meet this goal has become more difficult, threatening to reach a plateau. Due to the difficulty in reducing the size of computers because of size limitations of transistors and integrated circuits, wetware provides an unconventional alternative. A wetware computer composed of neurons is an ideal concept because, unlike conventional materials which operate in binary (on/off), a neuron can shift between thousands of states, constantly altering its chemical conformation, and redirecting electrical pulses through over 200,000 channels in any of its many synaptic connections. Because of this large difference in the possible settings for any one neuron, compared to the binary limitations of conventional computers, the space limitations are far fewer. == Background == The concept of wetware is distinct and unconventional and draws slight resonance with both hardware and software from conventional computers. While hardware is understood as the physical architecture of traditional computational devices, comprising integrated circuits and supporting infrastructure, software represents the encoded architecture of storage and instructions. Wetware is a separate concept that uses the formation of organic molecules, mostly complex cellular structures (such as neurons), to create a computational device such as a computer. In wetware, the ideas of hardware and software are intertwined and interdependent. The molecular and chemical composition of the organic or biological structure would represent not only the physical structure of the wetware but also the software, being continually reprogrammed by the discrete shifts in electrical pulses and chemical concentration gradients as the molecules change their structures to communicate signals. The responsiveness of a cell, proteins, and molecules to changing conformations, both within their structures and around them, ties the idea of internal programming and external structure together in a way that is alien to the current model of conventional computer architecture. The structure of wetware represents a model where the external structure and internal programming are interdependent and unified; meaning that changes to the programming or internal communication between molecules of the device would represent a physical change in the structure. The dynamic nature of wetware borrows from the function of complex cellular structures in biological organisms. The combination of "hardware" and "software" into one dynamic, and interdependent system which uses organic molecules and complexes to create an unconventional model for computational devices is a specific example of applied biorobotics. === The cell as a model of wetware === Cells in many ways can be seen as their form of naturally occurring wetware, similar to the concept that the human brain is the preexisting model system for complex wetware. In his book Wetware: A Computer in Every Living Cell (2009) Dennis Bray explains his theory that cells, which are the most basic form of life, are just a highly complex computational structure, like a computer. To simplify one of his arguments a cell can be seen as a type of computer, using its structured architecture. In this architecture, much like a traditional computer, many smaller components operate in tandem to receive input, process the information, and compute an output. In an overly simplified, non-technical analysis, cellular function can be broken into the following components: Information and instructions for execution are stored as DNA in the cell, RNA acts as a source for distinctly encoded input, processed by ribosomes and other transcription factors to access and process the DNA and to output a protein. Bray's argument in favor of viewing cells and cellular structures as models of natural computational devices is important when considering the more applied theories of wetware to biorobotics. === Biorobotics === Wetware and biorobotics are closely related concepts, which both borrow from similar overall principles. A biorobotic structure can be defined as a system modeled from a preexisting organic complex or model such as cells (neurons) or more complex structures like organs (brain) or whole organisms. Unlike wetware, the concept of biorobotics is not always a system composed of organic molecules, but instead could be composed of conventional material which is designed and assembled in a structure similar or derived from a biological model. Biorobotics have many applications and are used to address the challenges of conventional computer architecture. Conceptually, designing a program, robot, or computational device after a preexisting biological model such as a cell, or even a whole organism, provides the engineer or programmer the benefits of incorporating into the structure the evolutionary advantages of the model. == Effects on users == Wetware technologies such as BCIs and neuromorphic chips offer new possibilities for user autonomy. For those with disabilities, such systems could restore motor or sensory functions and enhance quality of life. However, these technologies raise ethical questions: cognitive privacy, consent over biological data, and risk of exploitation. Without proper oversight, wetware technologies may also widen inequality, favoring those with access to cognitive enhancements. Open governance frameworks and ethical AI design grounded in neuro ethics will be essential. With the development of wetware devices, disparities in access could exacerbate social inequalities, benefiting those who have resources to enhance cognitive or physical abilities. It is necessary to create strong ethical frameworks, inclusive development practices, and open systems of governance to reduce risks and make sure that wetware advances are beneficial to all segments of society. == Applications and goals == === Basic neurocomputer composed of leech neurons === In 1999 William Ditto and his team of researchers at Georgia Institute of Technology and Emory University created a basic form of a wetware computer capable of simple addition by harnessing leech neurons. Leeches were used as a model organism due to the large size of their neuron, and the ease associated with their collection and manipulation. However, these results have never been published in a peer-reviewed journal, prompting questions about the validity of the claims. The computer was able to complete basic addition through electrical probes

Automated essay scoring

Automated essay scoring (AES) is the use of specialized computer programs to assign grades to essays written in an educational setting. It is a form of educational assessment and an application of natural language processing. Its objective is to classify a large set of textual entities into a small number of discrete categories, corresponding to the possible grades, for example, the numbers 1 to 6. Therefore, it can be considered a problem of statistical classification. Several factors have contributed to a growing interest in AES. Among them are cost, accountability, standards, and technology. Rising education costs have led to pressure to hold the educational system accountable for results by imposing standards. The advance of information technology promises to measure educational achievement at reduced cost. The use of AES for high-stakes testing in education has generated significant backlash, with opponents pointing to research that computers cannot yet grade writing accurately and arguing that their use for such purposes promotes teaching writing in reductive ways (i.e. teaching to the test). == History == Most historical summaries of AES trace the origins of the field to the work of Ellis Batten Page. In 1966, he argued for the possibility of scoring essays by computer, and in 1968 he published his successful work with a program called Project Essay Grade (PEG). Using the technology of that time, computerized essay scoring would not have been cost-effective, so Page abated his efforts for about two decades. Eventually, Page sold PEG to Measurement Incorporated. By 1990, desktop computers had become so powerful and so widespread that AES was a practical possibility. As early as 1982, a UNIX program called Writer's Workbench was able to offer punctuation, spelling and grammar advice. In collaboration with several companies (notably Educational Testing Service), Page updated PEG and ran some successful trials in the early 1990s. Peter Foltz and Thomas Landauer developed a system using a scoring engine called the Intelligent Essay Assessor (IEA). IEA was first used to score essays in 1997 for their undergraduate courses. It is now a product from Pearson Educational Technologies and used for scoring within a number of commercial products and state and national exams. IntelliMetric is Vantage Learning's AES engine. Its development began in 1996. It was first used commercially to score essays in 1998. Educational Testing Service offers "e-rater", an automated essay scoring program. It was first used commercially in February 1999. Jill Burstein was the team leader in its development. ETS's Criterion Online Writing Evaluation Service uses the e-rater engine to provide both scores and targeted feedback. Lawrence Rudner has done some work with Bayesian scoring, and developed a system called BETSY (Bayesian Essay Test Scoring sYstem). Some of his results have been published in print or online, but no commercial system incorporates BETSY as yet. Under the leadership of Howard Mitzel and Sue Lottridge, Pacific Metrics developed a constructed response automated scoring engine, CRASE. Currently utilized by several state departments of education and in a U.S. Department of Education-funded Enhanced Assessment Grant, Pacific Metrics’ technology has been used in large-scale formative and summative assessment environments since 2007. Measurement Inc. acquired the rights to PEG in 2002 and has continued to develop it. In 2012, the Hewlett Foundation sponsored a competition on Kaggle called the Automated Student Assessment Prize (ASAP). 201 challenge participants attempted to predict, using AES, the scores that human raters would give to thousands of essays written to eight different prompts. The intent was to demonstrate that AES can be as reliable as human raters, or more so. The competition also hosted a separate demonstration among nine AES vendors on a subset of the ASAP data. Although the investigators reported that the automated essay scoring was as reliable as human scoring, this claim was not substantiated by any statistical tests because some of the vendors required that no such tests be performed as a precondition for their participation. Moreover, the claim that the Hewlett Study demonstrated that AES can be as reliable as human raters has since been strongly contested, including by Randy E. Bennett, the Norman O. Frederiksen Chair in Assessment Innovation at the Educational Testing Service. Some of the major criticisms of the study have been that five of the eight datasets consisted of paragraphs rather than essays, four of the eight data sets were graded by human readers for content only rather than for writing ability, and that rather than measuring human readers and the AES machines against the "true score", the average of the two readers' scores, the study employed an artificial construct, the "resolved score", which in four datasets consisted of the higher of the two human scores if there was a disagreement. This last practice, in particular, gave the machines an unfair advantage by allowing them to round up for these datasets. In 1966, Page hypothesized that, in the future, the computer-based judge will be better correlated with each human judge than the other human judges are. Despite criticizing the applicability of this approach to essay marking in general, this hypothesis was supported for marking free text answers to short questions, such as those typical of the British GCSE system. Results of supervised learning demonstrate that the automatic systems perform well when marking by different human teachers is in good agreement. Unsupervised clustering of answers showed that excellent papers and weak papers formed well-defined clusters, and the automated marking rule for these clusters worked well, whereas marks given by human teachers for the third cluster ('mixed') can be controversial, and the reliability of any assessment of works from the 'mixed' cluster can often be questioned (both human and computer-based). == Different dimensions of essay quality == According to a recent survey, modern AES systems try to score different dimensions of an essay's quality in order to provide feedback to users. These dimensions include the following items: Grammaticality: following grammar rules Usage: using of prepositions, word usage Mechanics: following rules for spelling, punctuation, capitalization Style: word choice, sentence structure variety Relevance: how relevant of the content to the prompt Organization: how well the essay is structured Development: development of ideas with examples Cohesion: appropriate use of transition phrases Coherence: appropriate transitions between ideas Thesis Clarity: clarity of the thesis Persuasiveness: convincingness of the major argument == Procedure == From the beginning, the basic procedure for AES has been to start with a training set of essays that have been carefully hand-scored. The program evaluates surface features of the text of each essay, such as the total number of words, the number of subordinate clauses, or the ratio of uppercase to lowercase letters—quantities that can be measured without any human insight. It then constructs a mathematical model that relates these quantities to the scores that the essays received. The same model is then applied to calculate scores of new essays. Recently, one such mathematical model was created by Isaac Persing and Vincent Ng. which not only evaluates essays on the above features, but also on their argument strength. It evaluates various features of the essay, such as the agreement level of the author and reasons for the same, adherence to the prompt's topic, locations of argument components (major claim, claim, premise), errors in the arguments, cohesion in the arguments among various other features. In contrast to the other models mentioned above, this model is closer in duplicating human insight while grading essays. Due to the growing popularity of deep neural networks, deep learning approaches have been adopted for automated essay scoring, generally obtaining superior results, often surpassing inter-human agreement levels. The various AES programs differ in what specific surface features they measure, how many essays are required in the training set, and most significantly in the mathematical modeling technique. Early attempts used linear regression. Modern systems may use linear regression or other machine learning techniques often in combination with other statistical techniques such as latent semantic analysis and Bayesian inference. The automated essay scoring task has also been studied in the cross-domain setting using machine learning models, where the models are trained on essays written for one prompt (topic) and tested on essays written for another prompt. Successful approaches in the cross-domain scenario are based on deep neural networks or models that combine deep and shallow features. == Criteria for success == Any method of a