A wetware computer is an organic computer (which can also be known as an artificial organic brain or a neurocomputer) composed of organic material "wetware" such as "living" neurons. Wetware computers composed of neurons are different than conventional computers because they use biological materials, and offer the possibility of substantially more energy-efficient computing. While a wetware computer is still largely conceptual, there has been limited success with construction and prototyping, which has acted as a proof of the concept's realistic application to computing in the future. The most notable prototypes have stemmed from the research completed by biological engineer William Ditto during his time at the Georgia Institute of Technology. His work constructing a simple neurocomputer capable of basic addition from leech neurons in 1999 was a significant discovery for the concept. This research was a primary example driving interest in creating these artificially constructed, but still organic brains. == Origins and theoretical foundations == The term wetware came from cyberpunk fiction, notably through Gibson's Neuromancer, but was quickly taken up in scientific literature to explain computation by biological material. Theories of early biological computation borrowed from Alan Turing's morphogenesis model, which showed that chemical interactions could produce complex patterns without centralized control. Hopfield's associative memory networks also provided a foundation for biological information systems with fault tolerance and self-organization. == Major characteristics and processes == Biological wetware systems demonstrate dynamic reconfigurability underpinned by neuroplasticity and enable continuous learning and adaptation. Reaction-diffusion-based computing and molecular logic gates allow spatially parallel information processing unachievable in conventional systems. These systems also show fault tolerance and self-repair at the cellular and network level. The development of cerebral organoids—miniature lab-grown brains—demonstrates spontaneous learning behavior and suggests biological tissue as a viable computational substrate. == Overview == The concept of wetware is an application of specific interest to the field of computer manufacturing. Moore's law, which states that the number of transistors which can be placed on a silicon chip is doubled roughly every two years, has acted as a goal for the industry for decades, but as the size of computers continues to decrease, the ability to meet this goal has become more difficult, threatening to reach a plateau. Due to the difficulty in reducing the size of computers because of size limitations of transistors and integrated circuits, wetware provides an unconventional alternative. A wetware computer composed of neurons is an ideal concept because, unlike conventional materials which operate in binary (on/off), a neuron can shift between thousands of states, constantly altering its chemical conformation, and redirecting electrical pulses through over 200,000 channels in any of its many synaptic connections. Because of this large difference in the possible settings for any one neuron, compared to the binary limitations of conventional computers, the space limitations are far fewer. == Background == The concept of wetware is distinct and unconventional and draws slight resonance with both hardware and software from conventional computers. While hardware is understood as the physical architecture of traditional computational devices, comprising integrated circuits and supporting infrastructure, software represents the encoded architecture of storage and instructions. Wetware is a separate concept that uses the formation of organic molecules, mostly complex cellular structures (such as neurons), to create a computational device such as a computer. In wetware, the ideas of hardware and software are intertwined and interdependent. The molecular and chemical composition of the organic or biological structure would represent not only the physical structure of the wetware but also the software, being continually reprogrammed by the discrete shifts in electrical pulses and chemical concentration gradients as the molecules change their structures to communicate signals. The responsiveness of a cell, proteins, and molecules to changing conformations, both within their structures and around them, ties the idea of internal programming and external structure together in a way that is alien to the current model of conventional computer architecture. The structure of wetware represents a model where the external structure and internal programming are interdependent and unified; meaning that changes to the programming or internal communication between molecules of the device would represent a physical change in the structure. The dynamic nature of wetware borrows from the function of complex cellular structures in biological organisms. The combination of "hardware" and "software" into one dynamic, and interdependent system which uses organic molecules and complexes to create an unconventional model for computational devices is a specific example of applied biorobotics. === The cell as a model of wetware === Cells in many ways can be seen as their form of naturally occurring wetware, similar to the concept that the human brain is the preexisting model system for complex wetware. In his book Wetware: A Computer in Every Living Cell (2009) Dennis Bray explains his theory that cells, which are the most basic form of life, are just a highly complex computational structure, like a computer. To simplify one of his arguments a cell can be seen as a type of computer, using its structured architecture. In this architecture, much like a traditional computer, many smaller components operate in tandem to receive input, process the information, and compute an output. In an overly simplified, non-technical analysis, cellular function can be broken into the following components: Information and instructions for execution are stored as DNA in the cell, RNA acts as a source for distinctly encoded input, processed by ribosomes and other transcription factors to access and process the DNA and to output a protein. Bray's argument in favor of viewing cells and cellular structures as models of natural computational devices is important when considering the more applied theories of wetware to biorobotics. === Biorobotics === Wetware and biorobotics are closely related concepts, which both borrow from similar overall principles. A biorobotic structure can be defined as a system modeled from a preexisting organic complex or model such as cells (neurons) or more complex structures like organs (brain) or whole organisms. Unlike wetware, the concept of biorobotics is not always a system composed of organic molecules, but instead could be composed of conventional material which is designed and assembled in a structure similar or derived from a biological model. Biorobotics have many applications and are used to address the challenges of conventional computer architecture. Conceptually, designing a program, robot, or computational device after a preexisting biological model such as a cell, or even a whole organism, provides the engineer or programmer the benefits of incorporating into the structure the evolutionary advantages of the model. == Effects on users == Wetware technologies such as BCIs and neuromorphic chips offer new possibilities for user autonomy. For those with disabilities, such systems could restore motor or sensory functions and enhance quality of life. However, these technologies raise ethical questions: cognitive privacy, consent over biological data, and risk of exploitation. Without proper oversight, wetware technologies may also widen inequality, favoring those with access to cognitive enhancements. Open governance frameworks and ethical AI design grounded in neuro ethics will be essential. With the development of wetware devices, disparities in access could exacerbate social inequalities, benefiting those who have resources to enhance cognitive or physical abilities. It is necessary to create strong ethical frameworks, inclusive development practices, and open systems of governance to reduce risks and make sure that wetware advances are beneficial to all segments of society. == Applications and goals == === Basic neurocomputer composed of leech neurons === In 1999 William Ditto and his team of researchers at Georgia Institute of Technology and Emory University created a basic form of a wetware computer capable of simple addition by harnessing leech neurons. Leeches were used as a model organism due to the large size of their neuron, and the ease associated with their collection and manipulation. However, these results have never been published in a peer-reviewed journal, prompting questions about the validity of the claims. The computer was able to complete basic addition through electrical probes
List of performance analysis tools
This is a list of performance analysis tools for use in software development. == General purpose, language independent == The following tools work based on log files that can be generated from various systems. time (Unix) - can be used to determine the run time of a program, separately counting user time vs. system time, and CPU time vs. clock time. timem (Unix) - can be used to determine the wall-clock time, CPU time, and CPU utilization similar to time (Unix) but supports numerous extensions. Supports reporting peak resident set size, major and minor page faults, priority and voluntary context switches via getrusage. Supports sampling procfs on supporting systems to report metrics such as page-based resident set size, virtual memory size, read-bytes, and write-bytes, etc. Supports collecting hardware counters when built with PAPI support. == Multiple languages == The following tools work for multiple languages or binaries. == C and C++ == Arm MAP, a performance profiler supporting Linux platforms. AppDynamics, an application performance management service for C/C++ applications via SDK. AQtime Pro, a performance profiler and memory allocation debugger that can be integrated into Microsoft Visual Studio, and Embarcadero RAD Studio, or can run as a stand-alone application. IBM Rational Purify was a memory debugger allowing performance analysis. Instruments (bundled with Xcode) is used to profile an executable's memory allocations, time usage, filesystem activity, GPU activity etc. Intel Parallel Studio contains Intel VTune Amplifier, which tunes both serial and parallel programs. It also includes Intel Advisor and Intel Inspector. Intel Advisor optimizes vectorization (use of SIMD instructions) and prototypes threading implementations. Intel Inspector detects and debugs races, deadlocks and memory errors. Parasoft Insure++ provides a graphical tool that displays and animates memory allocations in real time to expose memory blowout, fragmentation, overuse, bottlenecks and leaks. Visual Studio Team System Profiler, commercial profiler by Microsoft. == Java == inspectIT is an open-source application performance management (APM) service for monitoring and analyzing software applications, available under the Apache License, Version 2.0 (ALv2). JConsole is the profiler which comes with the Java Development Kit JProfiler JRockit Mission Control, a profiler with low overhead. Netbeans Profiler, a profiler integrated into the NetBeans IDE (internally uses jvisualvm profiler) Plumbr, Java application performance monitoring with automated root cause detection. Links memory leaks, GC inefficiency, slow database and external web service calls, locked threads, and other performance problems to the line in source code that causes them. OverOps, Continuous reliability for the modern software supply chain, automatically detect and deliver root cause automation for all errors. VisualVM is a visual tool integrating several commandline JDK tools and lightweight profiling capabilities. It is bundled with the Java Development Kit since version 6, update 7. == JavaScript == The Firefox web browser's developer tools contain a Performance tool, which gives insight into JavaScript performance of a website. Microsoft Visual Studio AJAX Profiling Extensions is a free profiling tool for JavaScript by Microsoft Research. == .NET == CLR Profiler is a free memory profiler provided by Microsoft for CLR applications. GlowCode is a performance and memory profiler for .NET applications using C# and other .NET languages. It identifies time-intensive functions and detects memory leaks and errors in native, managed and mixed Windows x64 and x86 applications. Visual Studio == PHP == BlackFire.io Dbg Xdebug is a PHP extension which provides debugging and profiling capabilities.
Knowledge space
In mathematical psychology and education theory, a knowledge space is a combinatorial structure used to formulate mathematical models describing the progression of a human learner. Knowledge spaces were introduced in 1985 by Jean-Paul Doignon and Jean-Claude Falmagne, and remain in extensive use in the education theory. Modern applications include two computerized tutoring systems, ALEKS and the defunct RATH. Formally, a knowledge space assumes that a domain of knowledge is a collection of concepts or skills, each of which must be eventually mastered. Not all concepts are interchangeable; some require other concepts as prerequisites. Conversely, competency at one skill may ease the acquisition of another through similarity. A knowledge space marks out which collections of skills are feasible: they can be learned without mastering any other skills. Under reasonable assumptions, the collection of feasible competencies forms the mathematical structure known as an antimatroid. Researchers and educators usually explore the structure of a discipline's knowledge space as a latent class model. == Motivation == Knowledge Space Theory attempts to address shortcomings of standardized testing when used in educational psychometry. Common tests, such as the SAT and ACT, compress a student's knowledge into a very small range of ordinal ranks, in the process effacing the conceptual dependencies between questions. Consequently, the tests cannot distinguish between true understanding and guesses, nor can they identify a student's particular weaknesses, only the general proportion of skills mastered. The goal of knowledge space theory is to provide a language by which exams can communicate What the student can do and What the student is ready to learn. == Model structure == Knowledge Space Theory-based models presume that an educational subject S can be modeled as a finite set Q of concepts, skills, or topics. Each feasible state of knowledge about S is then a subset of Q; the set of all such feasible states is K. The precise term for the information (Q, K) depends on the extent to which K satisfies certain axioms: A knowledge structure assumes that K contains the empty set (a student may know nothing about S) and Q itself (a student may have fully mastered S). A knowledge space is a knowledge structure that is closed under set union: if, for each topic, there is an expert in a class on that topic, then it is possible, with enough time and effort, for each student in the class to become an expert on all those topics simultaneously. A quasi-ordinal knowledge space is a knowledge space that is also closed under set intersection: if student a knows topics A and B; and student c knows topics B and C; then it is possible for another student b to know only topic B. A well-graded knowledge space or learning space is a knowledge space satisfying the following axiom: If S∈K, then there exists x∈S such that S\{x}∈K In educational terms, any feasible body of knowledge can be learned one concept at a time. === Prerequisite partial order === The more contentful axioms associated with quasi-ordinal and well-graded knowledge spaces each imply that the knowledge space forms a well-understood (and heavily studied) mathematical structure: A quasi-ordinal knowledge space can be associated with a distributive lattice under set union and set intersection. The name "quasi-ordinal" arises from Birkhoff's representation theorem, which explains that distributive lattices uniquely correspond to partial orders. A well-graded knowledge space is an antimatroid, a type of mathematical structure that describes certain problems solvable with a greedy algorithm. In either case, the mathematical structure implies that set inclusion defines partial order on K, interpretable as an educational prerequirement: if a(⪯)b in this partial order, then a must be learned before b. === Inner and outer fringe === The prerequisite partial order does not uniquely identify a curriculum; some concepts may lead to a variety of other possible topics. But the covering relation associated with the prerequisite partial does control curricular structure: if students know a before a lesson and b immediately after, then b must cover a in the partial order. In such a circumstance, the new topics covered between a and b constitute the outer fringe of a ("what the student was ready to learn") and the inner fringe of b ("what the student just learned"). == Construction of knowledge spaces == In practice, there exist several methods to construct knowledge spaces. The most frequently used method is querying experts. There exist several querying algorithms that allow one or several experts to construct a knowledge space by answering a sequence of simple questions. Another method is to construct the knowledge space by explorative data analysis (for example by item tree analysis) from data. A third method is to derive the knowledge space from an analysis of the problem solving processes in the corresponding domain.
Generative AI Copyright Disclosure Act
The Generative AI Copyright Disclosure Act is a piece of legislation introduced by California Representative Adam Schiff in the United States Congress on April 9, 2024. It concerns the transparency of companies regarding their use of copyrighted work to train their generative artificial intelligence (AI) models. The legislation requires the submission of a notice regarding the identity and the uniform resource locator (URL) address of the copyrighted works used in the training data to the Register of Copyrights at least 30 days before the public release of the new or updated version of the AI model; it does not ban the use of copyrighted works for AI training. The bill's requirements would apply retroactively to prior AI models. Violation penalties would start at US$5,000. The legislation does not have a maximum penalty assessment that can be charged. The bill by Schiff was introduced a few days after The New York Times published an article regarding the business activities of major tech firms, including Google and Meta, in the training of their generative AI platforms on April 6, 2024. The legislation is supported by the Professional Photographers of America (PPA), SAG-AFTRA, the Writers Guild of America, the International Alliance of Theatrical Stage Employees (IATSE), the Recording Industry Association of America (RIAA), and others.
Danilo McGarry
Danilo McGarry (born 1985) is a British tech executive, writer, and speaker who has led AI initiatives in finance and healthcare. == Early life and education == Danilo McGarry was born in 1985. He received a Bachelor of Science (BSc) with honors in Business Management from the University of Bath. == Career == McGarry began his career in technology and financial services, with positions at companies including Motorola, JPMorgan Chase, and BNP Paribas. He later joined the Royal Bank of Canada (RBC) as an analyst and later became a director, where he led transformation initiatives involving robotic process automation (RPA) in the bank's capital markets operations. McGarry subsequently moved into leadership roles focused on AI. At Citigroup, he served as Head of Artificial Intelligence and Machine Learning, where he launched an AI-driven robotics and automation initiative. At UnitedHealth Group (UHG), he held a senior role in the company's automation program, which utilized a large fleet of software robots in its healthcare operations. In December 2019, McGarry was appointed Global Head of AI & Automation at Alter Domus, a multinational financial services firm. In this role, he established a new AI and automation department. He left the firm in late 2023 to establish his businesses. In 2025, the Chartered Institute of Personnel and Development (CIPD) appointed him as its strategic adviser on artificial intelligence.
List of data science software
This is a list of data science software and platforms used in data science, which includes programming languages, programming environments, machine learning frameworks, data engineering tools, statistical software, data analysis, plotting, MLOps systems, and more. == Programming languages == == Development environments == These interactive notebooks, IDEs, and platforms provide specialised development environments. Apache Zeppelin Architect — Eclipse (software) CoCalc Dataiku Data Science Studio FreeMat GNU Octave Google Colab DataSpell Jupyter Notebook / JupyterLab Kaggle Notebooks MATLAB O-Matrix PyCharm RStudio SAS (software) and SAS Studio Spyder Visual Studio Code == Machine and deep learning software == The Machine learning / deep learning tools support development in those fields. == Data engineering == Examples of Data engineering tools. Apache Airflow Apache Flink Apache Hadoop Apache Kafka Apache NiFi Apache Spark Dask Data build tool (dbt) == Data mining == Examples of Data mining tools. === Free and open-source === === Proprietary === == Database management == === List of RDBMS === ==== Proprietary ==== == Data warehouses == Data warehouse environments include: Amazon Redshift Snowflake Google BigQuery Microsoft Azure Synapse Teradata Vertica == Data lakes == Data lake environments include: Apache Hadoop Cloudera Databricks Delta Lake Amazon S3 Google Cloud Storage Azure Data Lake == Algorithms == Apriori algorithm – frequent itemset mining and association rule learning in market basket analysis Backpropagation – algorithm for training artificial neural networks using gradient descent Decision Trees – tree-based algorithm for classification and regression Expectation–maximization algorithm – iterative procedure for maximum likelihood estimation with latent variables Gradient descent – iterative optimization algorithm for minimizing a loss function ID3 algorithm – used to generate a decision tree from a dataset K-Means – clustering algorithm based on minimizing within-cluster distances K-Nearest Neighbors (KNN) – instance-based learning and classification method Linear regression – estimation method for predicting a dependent variable based on independent variables Logistic regression – classification algorithm for predicting a binary outcome Naive Bayes – probabilistic classifier based on Bayes' theorem Ordinary least squares – estimation method for parameters in linear regression PageRank – graph-based algorithm for link analysis and search ranking Principal component analysis – technique to reduce high-dimensional data while preserving variance Q-learning – reinforcement learning algorithm for learning optimal actions Random forest – ensemble of decision trees for improved classification or regression Sequential minimal optimization – solver for training support vector machines Stochastic gradient descent – randomized variant of gradient descent for large-scale machine learning Support Vector Machines (SVM) – algorithm for finding a hyperplane to separate classes == Statistical software == === Open-source === === Public domain === CSPro Dataplot Epi Map X-13ARIMA-SEATS === Freeware === BV4.1 MINUIT WinBUGS Winpepi === Proprietary === == Data processing == Tools for Data processing and analysis: == Data and information visualization == Software for Data visualization: == Plotting software == Software for plotting data to support processing and visualise results. == Maps and geospatial visualization == ArcGIS Carto Epi Map GeoDA Google Earth Engine Leaflet Mapbox MountainsMap QGIS == Machine learning == MLOps and model deployment: BentoML Data Version Control (DVC) Kubeflow MLflow Seldon Core Streamlit TensorFlow Serving Weights & Biases == Data repositories == Kaggle – platform for data science competitions, datasets, and notebooks. OpenML – collaborative platform for sharing datasets, algorithms, and experiments. University of California, Irvine Machine Learning Repository Zenodo – open-access repository supported by CERN and the EU. == Educational data science software == Kaggle – online platform for data science education, competitions, datasets, and collaborative learning. KNIME – open-source data analytics platform used for teaching data science, machine learning, and workflow-based analysis. RapidMiner – used in academic research and education for data mining and machine learning. Statistics Online Computational Resource (SOCR) – online tools and instructional resources for statistics education. Tanagra (machine learning) – data mining software developed for research and teaching purposes. TinkerPlots – explore and analyze data through visual modeling.
Shakey the robot
Shakey the Robot was the first general-purpose mobile robot able to reason about its own actions. While other robots would have to be instructed on each individual step of completing a larger task, Shakey could analyze commands and break them down into basic chunks by itself. Due to its nature, the project combined research in robotics, computer vision, and natural language processing. Because of this, it was the first project that melded logical reasoning and physical action. Shakey was developed at the Artificial Intelligence Center of Stanford Research Institute (now called SRI International). Some of the most notable results of the project include the A search algorithm, the Hough transform, and the visibility graph method. == History == Shakey was developed from approximately 1966 through 1972 with Charles Rosen, Nils Nilsson and Peter Hart as project managers. Other major contributors included Alfred Brain, Sven Wahlstrom, Bertram Raphael, Richard Duda, Richard Fikes, Thomas Garvey, Helen Chan Wolf and Michael Wilber. The project was funded by the Defense Advanced Research Projects Agency (DARPA) based on a SRI proposal submitted in April 1964 for research in "Intelligent Automata", later "Intelligent Automata to Reconnaissance". It was originally designed to have two retractable arms. Now retired from active duty, Shakey is currently on view in a glass display case at the Computer History Museum in Mountain View, California. The project inspired numerous other robotics projects, most notably the Centibots. == Software == The robot's programming was primarily done in LISP. The Stanford Research Institute Problem Solver (STRIPS) planner it used was conceived as the main planning component for the software it utilized. As the first robot that was a logical, goal-based agent, Shakey experienced a limited world. A version of Shakey's world could contain a number of rooms connected by corridors, with doors and light switches available for the robot to interact with. Shakey had a short list of available actions within its planner. These actions involved traveling from one location to another, turning the light switches on and off, opening and closing the doors, climbing up and down from rigid objects, and pushing movable objects around. The STRIPS automated planner could devise a plan to enact all the available actions, even though Shakey himself did not have the capability to execute all the actions within the plan personally. An example mission for Shakey might be something like, an operator types the command "push the block off the platform" at a computer console. Shakey looks around, identifies a platform with a block on it, and locates a ramp in order to reach the platform. Shakey then pushes the ramp over to the platform, rolls up the ramp onto the platform, and pushes the block off the platform. == Hardware == Physically, the robot was particularly tall, and had an antenna for a radio link, sonar range finders, a television camera, on-board processors, and collision detection sensors ("bump detectors"). The robot's tall stature and tendency to shake resulted in its name: We worked for a month trying to find a good name for it, ranging from Greek names to whatnot, and then one of us said, 'Hey, it shakes like hell and moves around, let’s just call it Shakey.' == Research results == The development of Shakey provided far-reaching impact on the fields of robotics and artificial intelligence, as well as computer science in general. Some of the more notable results include the development of the A search algorithm, which is widely used in pathfinding and graph traversal, the process of plotting an efficiently traversable path between points; the Hough transform, which is a feature extraction technique used in image analysis, computer vision, and digital image processing; and the visibility graph method for finding Euclidean shortest paths among obstacles in the plane. == Media and awards == In 1969 the SRI published "SHAKEY: Experimentation in Robot Learning and Planning", a 24-minute video. The project then received media attention. This included an article in the New York Times on April 10, 1969. In 1970, Life referred to Shakey as the "first electronic person"; and in November 1970 National Geographic Magazine covered Shakey and the future of computers. The Association for the Advancement of Artificial Intelligence's AI Video Competition's awards are named "Shakeys" because of the significant impact of the 1969 video. Shakey was inducted into Carnegie Mellon University's Robot Hall of Fame in 2004 alongside such notables as ASIMO and C-3PO. Shakey has been honored with an IEEE Milestone in Electrical Engineering and Computing. Shakey was showcased in the BBC's Towards Tomorrow: Robot (1967) documentary.