CAMeL-View is a software application, which is used for the model based design of mechatronic systems (multi-body simulation, block diagrams, pneumatic systems, hydraulic systems, general simulation, linear analysis and Hardware-in-the-Loop). CAMeL-View enables object-oriented model creation of mechatronic systems through the use of graphic blocks. The basic elements of multi-body system dynamics, control technology, hydraulics and hardware connectivity support the modeling process. The user’s proprietary C-Code can also be integrated into the models, which allows CAMeL-View TestRig to be implemented in all phases of the model based design process ( modeling, physical testing and prototyping), and lends itself especially well to mechatronic system design. The model’s structure is described and displayed with the help of directional connectors. Physical connections (such as mechanical or hydraulic linkages) as well as input and output connections (signal flow) are also available. The input of equations is done via mathematical expressions, e.g. the input of constitutive differential equations in vector and matrix form. Based on the model’s structure, the descriptive equations are converted into non-linear state space representations and converted into executable C-Code. CAMeL-View supports the simulation process with a configurable “experiment environment” (for simulator and instrumentation components) which allows the user to apply simulation models to supported targets (MPC5200, TriCore, X86, etc.) without the need for additional software tools for Hardware-in-the-Loop applications. In addition, the generation of so-called S-Functions for use in Simulink and the generation of ANSI C-Code for use in stand-alone simulators is also supported. A particularly noteworthy feature in CAMeL-View TestRig is the way in which the descriptive equations for multi-body system models are created. All multi-body simulation formalisms used for code generation create their equations in the form of typical explicit differential equations (ODE). This is especially important in Hardware-in-the-Loop applications where the calculation of simulation results within a specific, defined time frame must be assured. Only then is it possible to implement complex multi-body simulation models for Hardware-in-the-Loop applications under stringent real-time conditions. These constraints cannot be met when using DAE-based methods. Additional Toolboxes are available for linear analysis (Eigenvalues, pole-zero analysis, frequency response, etc.) of VRML-based animation. Development of CAMeL-View began in 1991 in the Paderborn Mechatronic Laboratory of Professor Dr. Ing. J. Lückel. The software was based on predecessors that had been developed there since 1986. The name stands for Computer Aided Mechatronic Laboratory – Virtual Engineering Workbench and describes the basic intent of one of the specific demands placed on development engineers in the computer lab.
Super-resolution optical fluctuation imaging
Super-resolution optical fluctuation imaging (SOFI) is a post-processing method for the calculation of super-resolved images from recorded image time series that is based on the temporal correlations of independently fluctuating fluorescent emitters. SOFI has been developed for super-resolution of biological specimen that are labelled with independently fluctuating fluorescent emitters (organic dyes, fluorescent proteins). In comparison to other super-resolution microscopy techniques such as STORM or PALM that rely on single-molecule localization and hence only allow one active molecule per diffraction-limited area (DLA) and timepoint, SOFI does not necessitate a controlled photoswitching and/ or photoactivation as well as long imaging times. Nevertheless, it still requires fluorophores that are cycling through two distinguishable states, either real on-/off-states or states with different fluorescence intensities. In mathematical terms SOFI-imaging relies on the calculation of cumulants, for what two distinguishable ways exist. For one thing an image can be calculated via auto-cumulants that by definition only rely on the information of each pixel itself, and for another thing an improved method utilizes the information of different pixels via the calculation of cross-cumulants. Both methods can increase the final image resolution significantly although the cumulant calculation has its limitations. Actually SOFI is able to increase the resolution in all three dimensions. == Principle == Likewise to other super-resolution methods SOFI is based on recording an image time series on a CCD- or CMOS camera. In contrary to other methods the recorded time series can be substantially shorter, since a precise localization of emitters is not required and therefore a larger quantity of activated fluorophores per diffraction-limited area is allowed. The pixel values of a SOFI-image of the n-th order are calculated from the values of the pixel time series in the form of a n-th order cumulant, whereas the final value assigned to a pixel can be imagined as the integral over a correlation function. The finally assigned pixel value intensities are a measure of the brightness and correlation of the fluorescence signal. Mathematically, the n-th order cumulant is related to the n-th order correlation function, but exhibits some advantages concerning the resulting resolution of the image. Since in SOFI several emitters per DLA are allowed, the photon count at each pixel results from the superposition of the signals of all activated nearby emitters. The cumulant calculation now filters the signal and leaves only highly correlated fluctuations. This provides a contrast enhancement and therefore a background reduction for good measure. As it is implied in the figure on the left the fluorescence source distribution: ∑ k = 1 N δ ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) {\displaystyle \sum _{k=1}^{N}\delta ({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t)} is convolved with the system's point spread function (PSF) U(r). Hence the fluorescence signal at time t and position r → {\displaystyle {\vec {r}}} is given by F ( r → , t ) = ∑ k = 1 N U ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) . {\displaystyle F({\vec {r}},t)=\sum _{k=1}^{N}U({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t).} Within the above equations N is the amount of emitters, located at the positions r → k {\displaystyle {\vec {r}}_{k}} with a time-dependent molecular brightness ε k ⋅ s k {\displaystyle \varepsilon _{k}\cdot s_{k}} where ε k {\displaystyle \varepsilon _{k}} is a variable for the constant molecular brightness and s k ( t ) {\displaystyle s_{k}(t)} is a time-dependent fluctuation function. The molecular brightness is just the average fluorescence count-rate divided by the number of molecules within a specific region. For simplification it has to be assumed that the sample is in a stationary equilibrium and therefore the fluorescence signal can be expressed as a zero-mean fluctuation: δ F ( r → , t ) = F ( r → , t ) − ⟨ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=F({\vec {r}},t)-\langle F({\vec {r}},t)\rangle _{t}} where ⟨ ⋯ ⟩ t {\displaystyle \langle \cdots \rangle _{t}} denotes time-averaging. The auto-correlation here e.g. the second-order can then be described deductively as follows for a certain time-lag τ {\displaystyle \tau } : δ F ( r → , t ) = ⟨ δ F ( r → , t + τ ) ⋅ δ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=\langle \delta F({\vec {r}},t+\tau )\cdot \delta F({\vec {r}},t)\rangle _{t}} From these equations it follows that the PSF of the optical system has to be taken to the power of the order of the correlation. Thus in a second-order correlation the PSF would be reduced along all dimensions by a factor of 2 {\displaystyle {\sqrt {2}}} . As a result, the resolution of the SOFI-images increases according to this factor. === Cumulants versus correlations === Using only the simple correlation function for a reassignment of pixel values, would ascribe to the independency of fluctuations of the emitters in time in a way that no cross-correlation terms would contribute to the new pixel value. Calculations of higher-order correlation functions would suffer from lower-order correlations for what reason it is superior to calculate cumulants, since all lower-order correlation terms vanish. == Cumulant-calculation == === Auto-cumulants === For computational reasons it is convenient to set all time-lags in higher-order cumulants to zero so that a general expression for the n-th order auto-cumulant can be found: A C n ( r → , τ 1 … n − 1 = 0 ) = ∑ k = 1 N U n ( r → − r → k ) ε k n w k ( 0 ) {\displaystyle AC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\sum _{k=1}^{N}U^{n}({\vec {r}}-{\vec {r}}_{k})\varepsilon _{k}^{n}w_{k}(0)} w k {\displaystyle w_{k}} is a specific correlation based weighting function influenced by the order of the cumulant and mainly depending on the fluctuation properties of the emitters. Albeit there is no fundamental limitation in calculating very high orders of cumulants and thereby shrinking the FWHM of the PSF there are practical limitations according to the weighting of the values assigned to the final image. Emitters with a higher molecular brightness will show a strong increase in terms of the pixel cumulant value assigned at higher-orders as well as this performance can be expected from a diverse appearance of fluctuations of different emitters. A wide intensity range of the resulting image can therefore be expected and as a result dim emitters can get masked by bright emitters in higher-order images:. The calculation of auto-cumulants can be realized in a very attractive way in a mathematical sense. The n-th order cumulant can be calculated with a basic recursion from moments K n ( r → ) = μ n ( r → ) − ∑ i = 1 n − 1 ( n − 1 i ) K n − i ( r → ) μ i ( r → ) {\displaystyle K_{n}({\vec {r}})=\mu _{n}({\vec {r}})-\sum _{i=1}^{n-1}{\begin{pmatrix}n-1\\i\end{pmatrix}}K_{n-i}({\vec {r}})\mu _{i}({\vec {r}})} where K is a cumulant of the index's order, likewise μ {\displaystyle \mu } represents the moments. The term within the brackets indicates a binomial coefficient. This way of computation is straightforward in comparison with calculating cumulants with standard formulas. It allows for the calculation of cumulants with only little time of computing and is, as it is well implemented, even suitable for the calculation of high-order cumulants on large images. === Cross-cumulants === In a more advanced approach cross-cumulants are calculated by taking the information of several pixels into account. Cross-cumulants can be described as follows: C C n ( r → , τ 1 … n − 1 = 0 ) = ∏ j < l n U ( r → j − r → l n ) ⋅ ∑ i = 1 N U n ( r → i − ∑ k n r → k n ) ε i n w i ( 0 ) {\displaystyle CC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\prod _{j Margin-infused relaxed algorithm (MIRA) is a machine learning and online algorithm for multiclass classification problems. It is designed to learn a set of parameters (vector or matrix) by processing all the given training examples one-by-one and updating the parameters according to each training example, so that the current training example is classified correctly with a margin against incorrect classifications at least as large as their loss. The change of the parameters is kept as small as possible. A two-class version called binary MIRA simplifies the algorithm by not requiring the solution of a quadratic programming problem (see below). When used in a one-vs-all configuration, binary MIRA can be extended to a multiclass learner that approximates full MIRA, but may be faster to train. The flow of the algorithm looks as follows: The update step is then formalized as a quadratic programming problem: Find m i n ‖ w ( i + 1 ) − w ( i ) ‖ {\displaystyle min\|w^{(i+1)}-w^{(i)}\|} , so that s c o r e ( x t , y t ) − s c o r e ( x t , y ′ ) ≥ L ( y t , y ′ ) ∀ y ′ {\displaystyle score(x_{t},y_{t})-score(x_{t},y')\geq L(y_{t},y')\ \forall y'} , i.e. the score of the current correct training y {\displaystyle y} must be greater than the score of any other possible y ′ {\displaystyle y'} by at least the loss (number of errors) of that y ′ {\displaystyle y'} in comparison to y {\displaystyle y} . Optimal Discriminant Analysis (ODA) and the related classification tree analysis (CTA) are exact statistical methods that maximize predictive accuracy. For any specific sample and exploratory or confirmatory hypothesis, optimal discriminant analysis (ODA) identifies the statistical model that yields maximum predictive accuracy, assesses the exact Type I error rate, and evaluates potential cross-generalizability. Optimal discriminant analysis may be applied to > 0 dimensions, with the one-dimensional case being referred to as UniODA and the multidimensional case being referred to as MultiODA. Optimal discriminant analysis is an alternative to ANOVA (analysis of variance) and regression analysis. Analogical modeling (AM) is a formal theory of exemplar based analogical reasoning, proposed by Royal Skousen, professor of Linguistics and English language at Brigham Young University in Provo, Utah. It is applicable to language modeling and other categorization tasks. Analogical modeling is related to connectionism and nearest neighbor approaches, in that it is data-based rather than abstraction-based; but it is distinguished by its ability to cope with imperfect datasets (such as caused by simulated short term memory limits) and to base predictions on all relevant segments of the dataset, whether near or far. In language modeling, AM has successfully predicted empirically valid forms for which no theoretical explanation was known (see the discussion of Finnish morphology in Skousen et al. 2002). == Implementation == === Overview === An exemplar-based model consists of a general-purpose modeling engine and a problem-specific dataset. Within the dataset, each exemplar (a case to be reasoned from, or an informative past experience) appears as a feature vector: a row of values for the set of parameters that define the problem. For example, in a spelling-to-sound task, the feature vector might consist of the letters of a word. Each exemplar in the dataset is stored with an outcome, such as a phoneme or phone to be generated. When the model is presented with a novel situation (in the form of an outcome-less feature vector), the engine algorithmically sorts the dataset to find exemplars that helpfully resemble it, and selects one, whose outcome is the model's prediction. The particulars of the algorithm distinguish one exemplar-based modeling system from another. In AM, we think of the feature values as characterizing a context, and the outcome as a behavior that occurs within that context. Accordingly, the novel situation is known as the given context. Given the known features of the context, the AM engine systematically generates all contexts that include it (all of its supracontexts), and extracts from the dataset the exemplars that belong to each. The engine then discards those supracontexts whose outcomes are inconsistent (this measure of consistency will be discussed further below), leaving an analogical set of supracontexts, and probabilistically selects an exemplar from the analogical set with a bias toward those in large supracontexts. This multilevel search exponentially magnifies the likelihood of a behavior's being predicted as it occurs reliably in settings that specifically resemble the given context. === Analogical modeling in detail === AM performs the same process for each case it is asked to evaluate. The given context, consisting of n variables, is used as a template to generate 2 n {\displaystyle 2^{n}} supracontexts. Each supracontext is a set of exemplars in which one or more variables have the same values that they do in the given context, and the other variables are ignored. In effect, each is a view of the data, created by filtering for some criteria of similarity to the given context, and the total set of supracontexts exhausts all such views. Alternatively, each supracontext is a theory of the task or a proposed rule whose predictive power needs to be evaluated. It is important to note that the supracontexts are not equal peers one with another; they are arranged by their distance from the given context, forming a hierarchy. If a supracontext specifies all of the variables that another one does and more, it is a subcontext of that other one, and it lies closer to the given context. (The hierarchy is not strictly branching; each supracontext can itself be a subcontext of several others, and can have several subcontexts.) This hierarchy becomes significant in the next step of the algorithm. The engine now chooses the analogical set from among the supracontexts. A supracontext may contain exemplars that only exhibit one behavior; it is deterministically homogeneous and is included. It is a view of the data that displays regularity, or a relevant theory that has never yet been disproven. A supracontext may exhibit several behaviors, but contain no exemplars that occur in any more specific supracontext (that is, in any of its subcontexts); in this case it is non-deterministically homogeneous and is included. Here there is no great evidence that a systematic behavior occurs, but also no counterargument. Finally, a supracontext may be heterogeneous, meaning that it exhibits behaviors that are found in a subcontext (closer to the given context), and also behaviors that are not. Where the ambiguous behavior of the nondeterministically homogeneous supracontext was accepted, this is rejected because the intervening subcontext demonstrates that there is a better theory to be found. The heterogeneous supracontext is therefore excluded. This guarantees that we see an increase in meaningfully consistent behavior in the analogical set as we approach the given context. With the analogical set chosen, each appearance of an exemplar (for a given exemplar may appear in several of the analogical supracontexts) is given a pointer to every other appearance of an exemplar within its supracontexts. One of these pointers is then selected at random and followed, and the exemplar to which it points provides the outcome. This gives each supracontext an importance proportional to the square of its size, and makes each exemplar likely to be selected in direct proportion to the sum of the sizes of all analogically consistent supracontexts in which it appears. Then, of course, the probability of predicting a particular outcome is proportional to the summed probabilities of all the exemplars that support it. (Skousen 2002, in Skousen et al. 2002, pp. 11–25, and Skousen 2003, both passim) === Formulas === Given a context with n {\displaystyle n} elements: total number of pairings: n 2 {\displaystyle n^{2}} number of agreements for outcome i: n i 2 {\displaystyle n_{i}^{2}} number of disagreements for outcome i: n i ( n − n i ) {\displaystyle n_{i}(n-n_{i})} total number of agreements: ∑ n i 2 {\displaystyle \sum {n_{i}^{2}}} total number of disagreements: ∑ n i ( n − n i ) = n 2 − ∑ n i 2 {\displaystyle \sum {n_{i}(n-n_{i})}=n^{2}-\sum {n_{i}^{2}}} === Example === This terminology is best understood through an example. In the example used in the second chapter of Skousen (1989), each context consists of three variables with potential values 0-3 Variable 1: 0,1,2,3 Variable 2: 0,1,2,3 Variable 3: 0,1,2,3 The two outcomes for the dataset are e and r, and the exemplars are: 3 1 0 e 0 3 2 r 2 1 0 r 2 1 2 r 3 1 1 r We define a network of pointers like so: The solid lines represent pointers between exemplars with matching outcomes; the dotted lines represent pointers between exemplars with non-matching outcomes. The statistics for this example are as follows: n = 5 {\displaystyle n=5} n r = 4 {\displaystyle n_{r}=4} n e = 1 {\displaystyle n_{e}=1} total number of pairings: n 2 = 25 {\displaystyle n^{2}=25} number of agreements for outcome r: n r 2 = 16 {\displaystyle n_{r}^{2}=16} number of agreements for outcome e: n e 2 = 1 {\displaystyle n_{e}^{2}=1} number of disagreements for outcome r: n r ( n − n r ) = 4 {\displaystyle n_{r}(n-n_{r})=4} number of disagreements for outcome e: n e ( n − n e ) = 4 {\displaystyle n_{e}(n-n_{e})=4} total number of agreements: n r 2 + n e 2 = 17 {\displaystyle n_{r}^{2}+n_{e}^{2}=17} total number of disagreements: n r ( n − n r ) + n e ( n − n e ) = n 2 − ( n r 2 + n e 2 ) = 8 {\displaystyle n_{r}(n-n_{r})+n_{e}(n-n_{e})=n^{2}-(n_{r}^{2}+n_{e}^{2})=8} uncertainty or fraction of disagreement: 8 / 25 = .32 {\displaystyle 8/25=.32} Behavior can only be predicted for a given context; in this example, let us predict the outcome for the context "3 1 2". To do this, we first find all of the contexts containing the given context; these contexts are called supracontexts. We find the supracontexts by systematically eliminating the variables in the given context; with m variables, there will generally be 2 m {\displaystyle 2^{m}} supracontexts. The following table lists each of the sub- and supracontexts; x means "not x", and - means "anything". These contexts are shown in the venn diagram below: The next step is to determine which exemplars belong to which contexts in order to determine which of the contexts are homogeneous. The table below shows each of the subcontexts, their behavior in terms of the given exemplars, and the number of disagreements within the behavior: Analyzing the subcontexts in the table above, we see that there is only 1 subcontext with any disagreements: "3 1 2", which in the dataset consists of "3 1 0 e" and "3 1 1 r". There are 2 disagreements in this subcontext; 1 pointing from each of the exemplars to the other (see the pointer network pictured above). Therefore, only supracontexts containing this subcontext will contain any disagreements. We use a simple rule to identify the homogeneous supraco Hamilton C shell is a clone of the Unix C shell and utilities for Microsoft Windows created by Nicole Hamilton at Hamilton Laboratories as a completely original work, not based on any prior code. It was first released on OS/2 on December 12, 1988 and on Windows NT in July 1992. The OS/2 version was discontinued in 2003 but the Windows version continues to be actively supported. == Design == Hamilton C shell differs from the Unix C shell in several respects. These include its compiler architecture, its use of threads, and the decision to follow Windows rather than Unix conventions. === Parser === The original C shell uses an ad hoc parser. This has led to complaints about its limitations. It works well enough for the kinds of things users type interactively but not very well for the more complex commands a user might take time to write in a script. It is not possible, for example, to pipe the output of a foreach statement into grep. There was a limit to how complex a command it could handle. By contrast, Hamilton uses a top-down recursive descent parser that allows it to compile statements to an internal form before running them. As a result, statements can be nested or piped arbitrarily. The language has also been extended with built-in and user-defined procedures, local variables, floating point and additional expression, editing and wildcarding operators, including an "indefinite directory" wildcard construct written as "..." that matches zero or more directory levels as required to make the rest of the pattern match. === Threads === Lacking fork or a high performance way to recreate that functionality, Hamilton uses the Windows threads facilities instead. When a new thread is created, it runs within the same process space and it shares all of the process state. If one thread changes the current directory or the contents of memory, it's changed for all the threads. It's much cheaper to create a thread than a process but there's no isolation between them. To recreate the missing isolation of separate processes, the threads cooperate to share resources using locks. === Windows conventions === Hamilton differs from other Unix shells in that it also directly supports Windows conventions for drive letters, filename slashes, escape characters, etc. A physical neural network is a type of artificial neural network in which an electrically adjustable material is used to emulate the function of a neural synapse or a higher-order (dendritic) neuron model. "Physical" neural network is used to emphasize the reliance on physical hardware used to emulate neurons as opposed to software-based approaches. More generally the term is applicable to other artificial neural networks in which a memristor or other electrically adjustable resistance material is used to emulate a neural synapse. == Types of physical neural networks == === ADALINE === In the 1960s Bernard Widrow and Ted Hoff developed ADALINE (Adaptive Linear Neuron) which used electrochemical cells called memistors (memory resistors) to emulate synapses of an artificial neuron. The memistors were implemented as 3-terminal devices operating based on the reversible electroplating of copper such that the resistance between two of the terminals is controlled by the integral of the current applied via the third terminal. The ADALINE circuitry was briefly commercialized by the Memistor Corporation in the 1960s enabling some applications in pattern recognition. However, since the memistors were not fabricated using integrated circuit fabrication techniques the technology was not scalable and was eventually abandoned as solid-state electronics became mature. === Analog VLSI === In 1989 Carver Mead published his book Analog VLSI and Neural Systems, which spun off perhaps the most common variant of analog neural networks. The physical realization is implemented in analog VLSI. This is often implemented as field effect transistors in low inversion. Such devices can be modelled as translinear circuits. This is a technique described by Barrie Gilbert in several papers around mid 1970th, and in particular his Translinear Circuits from 1981. With this method circuits can be analyzed as a set of well-defined functions in steady-state, and such circuits assembled into complex networks. === Physical Neural Network === Alex Nugent describes a physical neural network as one or more nonlinear neuron-like nodes used to sum signals and nanoconnections formed from nanoparticles, nanowires, or nanotubes which determine the signal strength input to the nodes. Alignment or self-assembly of the nanoconnections is determined by the history of the applied electric field performing a function analogous to neural synapses. Numerous applications for such physical neural networks are possible. For example, a temporal summation device can be composed of one or more nanoconnections having an input and an output thereof, wherein an input signal provided to the input causes one or more of the nanoconnection to experience an increase in connection strength thereof over time. Another example of a physical neural network is taught by U.S. Patent No. 7,039,619 entitled "Utilized nanotechnology apparatus using a neural network, a solution and a connection gap," which issued to Alex Nugent by the U.S. Patent & Trademark Office on May 2, 2006. A further application of physical neural network is shown in U.S. Patent No. 7,412,428 entitled "Application of hebbian and anti-hebbian learning to nanotechnology-based physical neural networks," which issued on August 12, 2008. Nugent and Molter have shown that universal computing and general-purpose machine learning are possible from operations available through simple memristive circuits operating the AHaH plasticity rule. More recently, it has been argued that also complex networks of purely memristive circuits can serve as neural networks. === Phase change neural network === In 2002, Stanford Ovshinsky described an analog neural computing medium in which phase-change material has the ability to cumulatively respond to multiple input signals. An electrical alteration of the resistance of the phase change material is used to control the weighting of the input signals. === Memristive neural network === Greg Snider of HP Labs describes a system of cortical computing with memristive nanodevices. The memristors (memory resistors) are implemented by thin film materials in which the resistance is electrically tuned via the transport of ions or oxygen vacancies within the film. DARPA's SyNAPSE project has funded IBM Research and HP Labs, in collaboration with the Boston University Department of Cognitive and Neural Systems (CNS), to develop neuromorphic architectures which may be based on memristive systems. === Protonic artificial synapses === In 2022, researchers reported the development of nanoscale brain-inspired artificial synapses, using the ion proton (H+), for 'analog deep learning'.Margin-infused relaxed algorithm
Optimal discriminant analysis and classification tree analysis
Analogical modeling
Hamilton C shell
Physical neural network