Janyce Marbury Wiebe (1959–2018) was an American computer science specializing in natural language processing and known for her work on subjectivity, sentiment analysis, opinion mining, discourse processing, and word-sense disambiguation. == Early life and education == Wiebe was born in 1959, in Albany, New York. She majored in English at the Binghamton University, graduating in 1981, and completed a Ph.D. in computer science in 1990, at the University at Buffalo. Her dissertation, Recognizing Subjective Sentences: A Computational Investigation of Narrative Text, was supervised by philosopher William J. Rapaport. == Career == After postdoctoral research at the University of Toronto, she became an assistant professor at New Mexico State University in 1992. In 2000, she moved to the University of Pittsburgh, where she became a professor of computer science and director of the Intelligent Systems Program. == Recognition == Wiebe was named a Fellow of the Association for Computational Linguistics in 2015. == Death == She died of leukemia on December 10, 2018.
Single particle analysis
Single particle analysis is a group of related computerized image processing techniques used to analyze images from transmission electron microscopy (TEM). These methods were developed to improve and extend the information obtainable from TEM images of particulate samples, typically proteins or other large biological entities such as viruses. Individual images of stained or unstained particles are very noisy, making interpretation difficult. Combining several digitized images of similar particles together gives an image with stronger and more easily interpretable features. An extension of this technique uses single particle methods to build up a three-dimensional reconstruction of the particle. Using cryo-electron microscopy it has become possible to generate reconstructions with sub-nanometer, near-atomic resolution resolution first in the case of highly symmetric viruses, and now in smaller, asymmetric proteins as well. == Techniques == Single particle analysis can be done on both negatively stained and vitreous ice-embedded transmission electron cryomicroscopy (CryoTEM) samples. Single particle analysis methods are, in general, reliant on the sample being homogeneous, although techniques for dealing with conformational heterogeneity are being developed. Images (micrographs) are taken with an electron microscope using charged-coupled device (CCD) detectors coupled to a phosphorescent layer (in the past, they were instead collected on film and digitized using high-quality scanners). The image processing is carried out using specialized software programs, often run on multi-processor computer clusters. Depending on the sample or the desired results, various steps of two- or three-dimensional processing can be done. === Alignment and classification === Biological samples, and especially samples embedded in thin vitreous ice, are highly radiation sensitive, thus only low electron doses can be used to image the sample. This low dose, as well as variations in the metal stain used (if used) means images have high noise relative to the signal given by the particle being observed. By aligning several similar images to each other so they are in register and then averaging them, an image with higher signal-to-noise ratio can be obtained. As the noise is mostly randomly distributed and the underlying image features constant, by averaging the intensity of each pixel over several images only the constant features are reinforced. Typically, the optimal alignment (a translation and an in-plane rotation) to map one image onto another is calculated by cross-correlation. However, a micrograph often contains particles in multiple different orientations and/or conformations, and so to get more representative image averages, a method is required to group similar particle images together into multiple sets. This is normally carried out using one of several data analysis and image classification algorithms, such as multi-variate statistical analysis and hierarchical ascendant classification, or k-means clustering. Often data sets of tens of thousands of particle images are used, and to reach an optimal solution an iterative procedure of alignment and classification is used, whereby strong image averages produced by classification are used as reference images for a subsequent alignment of the whole data set. === Image filtering === Image filtering (band-pass filtering) is often used to reduce the influence of high and/or low spatial frequency information in the images, which can affect the results of the alignment and classification procedures. This is particularly useful in negative stain images. The algorithms make use of fast Fourier transforms (FFT), often employing Gaussian shaped soft-edged masks in reciprocal space to suppress certain frequency ranges. High-pass filters remove low spatial frequencies (such as ramp or gradient effects), leaving the higher frequencies intact. Low-pass filters remove high spatial frequency features and have a blurring effect on fine details. === Contrast transfer function === Due to the nature of image formation in the electron microscope, bright-field TEM images are obtained using significant underfocus. This, along with features inherent in the microscope's lens system, creates blurring of the collected images visible as a point spread function. The combined effects of the imaging conditions are known as the contrast transfer function (CTF), and can be approximated mathematically as a function in reciprocal space. Specialized image processing techniques such as phase flipping and amplitude correction / Wiener filtering can (at least partially) correct for the CTF, and allow high resolution reconstructions. === Three-dimensional reconstruction === Transmission electron microscopy images are projections of the object showing the distribution of density through the object, similar to medical X-rays. By making use of the projection-slice theorem a three-dimensional reconstruction of the object can be generated by combining many images (2D projections) of the object taken from a range of viewing angles. Proteins in vitreous ice ideally adopt a random distribution of orientations (or viewing angles), allowing a fairly isotropic reconstruction if a large number of particle images are used. This contrasts with electron tomography, where the viewing angles are limited due to the geometry of the sample/imaging set up, giving an anisotropic reconstruction. Filtered back projection is a commonly used method of generating 3D reconstructions in single particle analysis, although many alternative algorithms exist. Before a reconstruction can be made, the orientation of the object in each image needs to be estimated. Several methods have been developed to work out the relative Euler angles of each image. Some are based on common lines (common 1D projections and sinograms), others use iterative projection matching algorithms. The latter works by beginning with a simple, low resolution 3D starting model and compares the experimental images to projections of the model and creates a new 3D to bootstrap towards a solution. Methods are also available for making 3D reconstructions of helical samples (such as tobacco mosaic virus), taking advantage of the inherent helical symmetry. Both real space methods (treating sections of the helix as single particles) and reciprocal space methods (using diffraction patterns) can be used for these samples. === Tilt methods === The specimen stage of the microscope can be tilted (typically along a single axis), allowing the single particle technique known as random conical tilt. An area of the specimen is imaged at both zero and at high angle (~60-70 degrees) tilts, or in the case of the related method of orthogonal tilt reconstruction, +45 and −45 degrees. Pairs of particles corresponding to the same object at two different tilts (tilt pairs) are selected, and by following the parameters used in subsequent alignment and classification steps a three-dimensional reconstruction can be generated relatively easily. This is because the viewing angle (defined as three Euler angles) of each particle is known from the tilt geometry. 3D reconstructions from random conical tilt suffer from missing information resulting from a restricted range of orientations. Known as the missing cone (due to the shape in reciprocal space), this causes distortions in the 3D maps. However, the missing cone problem can often be overcome by combining several tilt reconstructions. Tilt methods are best suited to negatively stained samples, and can be used for particles that adsorb to the carbon support film in preferred orientations. The phenomenon known as charging or beam-induced movement makes collecting high-tilt images of samples in vitreous ice challenging. === Map visualization and fitting === Various software programs are available that allow viewing the 3D maps. These often enable the user to manually dock in protein coordinates (structures from X-ray crystallography, NMR, or a computational model such as one found in the AlphaFold Protein Structure Database) of subunits into the electron density. Several programs can also fit subunits computationally; as of the 2020s using these programs tend to produce better accuracy than manual docking because they can perform labor-intensive tasks such as: The scale of SPA-derived maps depends on knowing the pixel size (angstorms per pixel), which is not always accurate. Programs can automatically correct for this difference by using coordinate data or by using knowledge of chemical bonds. Many proteins are made up of several roughly rigid protein domains linked by flexible parts. Pre-existing coordinate data, whether experimental or computational, may not exactly match the inter-domain positioning of the cyro-EM map. Modern programs can automatically "chop" pre-existing coordinate data into individual domains and fit them in individually. For higher-resolution structures, it is pos
MacSpeech Scribe
MacSpeech Scribe is speech recognition software for Mac OS X designed specifically for transcription of recorded voice dictation. It runs on Mac OS X 10.6 Snow Leopard. The software transcribes dictation recorded by an individual speaker. Typically, the speaker will record their dictation using a digital recording device such as a handheld digital recorder, mobile smartphone (e.g. iPhone), or desktop or laptop computer with a suitable microphone. MacSpeech Scribe supports specific audio file formats for recorded dictation: .aif, .aiff, .wav, .mp4, .m4a, and .m4v. MacSpeech Scribe was originally developed by MacSpeech, Inc. and released February 11, 2010, at Macworld Expo in San Francisco. The product is now owned by Nuance Communications which acquired MacSpeech on February 16, 2010. Nuance is the developer of other speech recognition products including Dragon NaturallySpeaking for Windows, Dragon Dictate for Mac (formerly "MacSpeech Dictate"), and Dragon Dictation apps for iOS. Jeffery Battersby of Macworld noted in his September 2010 review of MacSpeech Scribe, v1.1: Small foibles aside, MacSpeech Scribe is a powerful and intelligent tool for transcribing your recorded speech. A simple training process and access to a wide variety of standard audio formats mean that you’ll be moving your spoken text to the printed page in a matter of minutes and with a minimum of hassle. Scribe is the best, simplest way for you to get your spoken word to the printed page. == Release history ==
Seeing AI
Seeing AI is an artificial intelligence application developed by Microsoft for iOS. Seeing AI uses the device camera to identify people and objects, and then the app audibly describes those objects for visually impaired people. == Capabilities == Seeing AI is primarily used to describe short text, documents, products, people, currency scenery, colors, handwriting and light. The app can scan a barcode to describe a product and uses sounds to assist the user in focusing on the barcode. When the app describes people, it attempts to estimate the person's age, gender, and emotional status. Additionally, in a test run by German journalists in December 2019, Seeing AI apparently used some sort of facial recognition system to identify people on photographs by name. Some functions are performed on the device, however more complex functions such as describing a scene or recognizing handwriting require an Internet connection. In December 2017, Seeing AI introduced the ability for currency recognition for US and Canadian dollar, British pounds and Euros. In December 2019, Seeing AI added support for five more languages, Dutch, French, German, Japanese, Spanish. Seeing AI is available in 70 countries such as Brazil, Argentina, Australia, Canada, Egypt, Albania, Bhutan, etc. Supported on iPhone 5C, 5S and later best performance with iPhone 6S, SE and later models
Executive Order 14110
Executive Order 14110, titled Executive Order on Safe, Secure, and Trustworthy Development and Use of Artificial Intelligence (sometimes referred to as "Executive Order on Artificial Intelligence") was the 126th executive order signed by former U.S. President Joe Biden. Signed on October 30, 2023, the order defines the administration's policy goals regarding artificial intelligence (AI), and orders executive agencies to take actions pursuant to these goals. The order is considered to be the most comprehensive piece of governance by the United States regarding AI. It was rescinded by U.S. President Donald Trump within hours of his assuming office on January 20, 2025. Policy goals outlined in the executive order pertain to promoting competition in the AI industry, preventing AI-enabled threats to civil liberties and national security, and ensuring U.S. global competitiveness in the AI field. The executive order required a number of major federal agencies to create dedicated "chief artificial intelligence officer" positions within their organizations. == Background == The drafting of the order was motivated by the rapid pace of development in generative AI models in the 2020s, including the release of large language model ChatGPT. Executive Order 14110 is the third executive order dealing explicitly with AI, with two AI-related executive orders being signed by then-President Donald Trump. The development of AI models without policy safeguards has raised a variety of concerns among experts and commentators. These range from future existential risk from advanced AI models to immediate concerns surrounding current technologies' ability to disseminate misinformation, enable discrimination, and undermine national security. In August 2023, Arati Prabhakar, the director of the Office of Science and Technology Policy, indicated that the White House was expediting its work on executive action on AI. A week prior to the executive order's unveiling, Prabhakar indicated that Office of Management and Budget (OMB) guidance on the order would be released "soon" after. == Policy goals and provisions == The order has been characterized as an effort for the United States to capture potential benefits from AI while mitigating risks associated with AI technologies. Upon signing the order, Biden stated that AI technologies were being developed at "warp speed", and argued that to "realize the promise of AI and avoid the risk, we need to govern this technology". Policy goals outlined by the order include the following: Promoting competition and innovation in the AI industry Upholding civil and labor rights and protecting consumers and their privacy from AI-enabled harms Specifying federal policies governing procurement and use of AI Developing watermarking systems for AI-generated content and warding off intellectual property theft stemming from the use of generative models Maintaining the nation's place as a global leader in AI == Impact on agencies == === Creation of chief AI officer positions === The executive order required a number of large federal agencies to appoint a chief artificial intelligence officer, with a number of departments having already appointed a relevant officer prior to the order. In the days following the order, news publication FedScoop confirmed that the General Services Administration (GSA) and the United States Department of Education appointed relevant chief AI officers. The National Science Foundation (NSF) also confirmed it had elevated an official to serve as its chief AI officer. === Department responsibilities === Under the executive order, the Department of Homeland Security (DHS) was responsible for developing AI-related security guidelines, including cybersecurity-related matters. The DHS will also work with private sector firms in sectors including the energy industry and other "critical infrastructure" to coordinate responses to AI-enabled security threats. Executive Order 14110 mandated the Department of Veterans Affairs to launch an AI technology competition aimed at reducing occupational burnout among healthcare workers through AI-assisted tools for routine tasks. The order also mandated the Department of Commerce's National Institute of Standards and Technology (NIST) to develop a generative artificial intelligence-focused resource to supplement the existing AI Risk Management Framework. == Analysis == The executive order has been described as the most comprehensive piece of governance by the United States government pertaining to AI. Earlier in 2023 prior to the signing of the order, the Biden administration had announced a Blueprint for an AI Bill of Rights, and had secured non-binding AI safety commitments from major tech companies. The issuing of the executive order comes at a time in which lawmakers including Senate Majority Leader Chuck Schumer have pushed for legislation to regulate AI in the 118th United States Congress. According to Axios, despite the wide scope of the executive order, it notably does not touch upon a number of AI-related policy proposals. This includes proposals for a "licensing regime" to government advanced AI models, which has received support from industry leaders including Sam Altman. Additionally, the executive order does not seek to prohibit 'high-risk' uses of AI technology, and does not aim to mandate that tech companies release information surrounding AI systems' training data and models. == Reception == === Political and media reception === The editorial board of the Houston Chronicle described the order as a "first step toward protecting humanity". The issuing of the order received praise from Democratic members of Congress, including Senator Richard Blumenthal (D-CT) and Representative Ted Lieu (D-CA). Representative Don Beyer (D-VA), who leads the House AI Caucus, praised the order as a "comprehensive strategy for responsible innovation", while arguing that Congress must take initiative to pass legislation on AI. The draft of the order received criticism from Republican Senator Ted Cruz (R-TX), who described it as creating "barriers to innovation disguised as safety measures". === Public reception === Polling from the AI Policy Institute showed that 69% of all voters support the executive order, while 15% oppose it. Breaking it down by party, support was at 78% for Democrats, 65% for independents, and 64% for Republicans. === Industry reception === The executive order received strong criticism from the Chamber of Commerce as well as tech industry groups including NetChoice and the Software and Information Industry Association, all of which count "Big Tech" companies Amazon, Meta, and Google as members. Representatives from the organizations argued that the executive order threatens to hinder private sector innovation. === Civil society reception === According to CNBC, a number of leaders advocacy organizations praised the executive order for its provisions on "AI fairness", while simultaneously urging congressional action to strengthen regulation. Maya Wiley, president and CEO of the Leadership Conference on Civil and Human Rights, praised the order while urging Congress to take initiative to "ensure that innovation makes us more fair, just, and prosperous, rather than surveilled, silenced, and stereotyped". A representative from the American Civil Liberties Union (ACLU) praised provisions of the order centered on combating AI-enabled discrimination, while also voiced concern over sections of the order focused on law enforcement and national security. === Second Trump administration === Hours after his inauguration as the 47th president of the United States, Donald Trump rescinded the order, labeling it, among several other of Biden's executive orders and actions, as "unpopular, inflationary, illegal, and radical practices".
Language engineering
Language engineering involves the creation of natural language processing systems, whose cost and outputs are measurable and predictable. It is a distinct field contrasted to natural language processing and computational linguistics. A recent trend of language engineering is the use of Semantic Web technologies for the creation, archiving, processing, and retrieval of machine processable language data. Meta-Language Engineering is a proposed extension of Language Engineering first recorded in 2025, associated with the work of Delyone de Paula Canedo Filho. The term is used to designate an approach that, in addition to natural language processing, encompasses the symbolic, cognitive, and epistemological structuring of language systems.
COTSBot
COTSBot is a small autonomous underwater vehicle (AUV) 4.5 feet (1.4 m) long, which is designed by Queensland University of Technology (QUT) to kill the very destructive crown-of-thorns starfish (Acanthaster planci) in the Great Barrier Reef off the north-east coast of Australia. It identifies its target using an image-analyzing neural net to analyze what an onboard camera sees, and then lethally injects the starfish with a bile salt solution using a needle on the end of a long underslung foldable arm. COTSBot uses GPS to navigate. The first version was created in the early 2000s with an accuracy rate of about 65%. After training COTSBot with machine learning, its accuracy rate rose to 99% by 2019. COTSBot is capable of killing 200 crown-of-thorns starfish with its two liters capacity of poison. COTSBot is capable of performing about 20 runs per day, but multiple COTSBots will be necessary to significantly impact the crown of thorns starfish populations. A smaller version of COTSBot called "RangerBot" is also being developed by QUT.