The Hyperion Cantos is a series of science fiction novels by Dan Simmons. The title was originally used for the collection of the first pair of books in the series, Hyperion and The Fall of Hyperion, and later came to refer to the overall storyline, including Endymion, The Rise of Endymion, and a number of short stories. More narrowly, inside the fictional storyline, after the first volume, the Hyperion Cantos is an epic poem written by the character Martin Silenus covering in verse form the events of the first two books. Of the four novels, Hyperion received the Hugo and Locus Awards in 1990; The Fall of Hyperion won the Locus and British Science Fiction Association Awards in 1991; and The Rise of Endymion received the Locus Award in 1998. All four novels were also nominated for various science fiction awards. == Works == === Hyperion (1989) === First published in 1989, Hyperion has the structure of a frame story, similar to Geoffrey Chaucer's Canterbury Tales and Giovanni Boccaccio's Decameron. The story weaves the interlocking tales of a diverse group of travelers sent on a pilgrimage to the Time Tombs on Hyperion. The travelers have been sent by the Hegemony (the government of the human star systems), the All Thing, and the Church of the Final Atonement, alternately known as the Shrike Church, to make a request of the Shrike. As they progress in their journey, each of the pilgrims tells their tale. === The Fall of Hyperion (1990) === This book concludes the story begun in Hyperion. It abandons the storytelling frame structure of the first novel, and is instead presented primarily as a series of dreams by John Keats. === Endymion (1996) === The story commences 274 years after the events in the previous novel. Few main characters from the first two books are present in the later two. The main character is Raul Endymion, an ex-soldier who receives a death sentence after an unfair trial. He is rescued by Martin Silenus and asked to perform a series of rather extraordinarily difficult tasks. The main task is to rescue and protect the daughter of Brawne Lamia (one of the main characters of Hyperion), Aenea, a messiah coming from the time period just after the first books via time travel. The Catholic Church has become a dominant force in the human universe and views Aenea as a potential threat to their power. The group of Aenea, Endymion, and A. Bettik (an android) evades the Church's forces on several worlds through use of the Consul's spaceship, ending the story on Earth. === The Rise of Endymion (1997) === This final novel in the series finishes the story begun in Endymion, expanding on the themes in Endymion, as Raul and Aenea battle the Church and meet their respective destinies. === Short stories === The series also includes three short stories: "Remembering Siri" (1983, included almost verbatim in Hyperion) "The Death of the Centaur" (1990) "Orphans of the Helix" (1999) == Development == The Hyperion universe originated when Simmons was an elementary school teacher, as an extended tale he told at intervals to his young students; this is recorded in "The Death of the Centaur", and its introduction. It then inspired his short story "Remembering Siri", which eventually became the nucleus around which Hyperion and The Fall of Hyperion formed. After the quartet was published came the short story "Orphans of the Helix". "Orphans" is currently the final work in the Cantos, both chronologically and internally. The original Hyperion Cantos has been described as a novel published in two volumes, published separately at first for reasons of length. In his introduction to "Orphans of the Helix", Simmons elaborates: Some readers may know that I've written four novels set in the "Hyperion Universe"—Hyperion, The Fall of Hyperion, Endymion, and The Rise of Endymion. A perceptive subset of those readers—perhaps the majority—know that this so-called epic actually consists of two long and mutually dependent tales, the two Hyperion stories combined and the two Endymion stories combined, broken into four books because of the realities of publishing. == Influences == Much of the appeal of the series stems from its extensive use of references and allusions from a wide array of thinkers such as Teilhard de Chardin, John Muir, Norbert Wiener, and to the poetry of John Keats, the famous 19th-century English Romantic poet, Norse mythology, and the monk Ummon. A large number of technological elements are acknowledged by Simmons to be inspired by elements of Out of Control: The New Biology of Machines, Social Systems, and the Economic World. The Hyperion series has many echoes of Jack Vance, explicitly acknowledged in one of the later books. The title of the first novel, "Hyperion", is taken from one of Keats's poems, the unfinished epic Hyperion. Similarly, the title of the third novel is from Keats' poem Endymion. Quotes from actual Keats poems and the fictional Cantos of Martin Silenus are interspersed throughout the novels. Simmons goes so far as to have two artificial reincarnations of John Keats ("cybrids": artificial intelligences in human bodies) play a major role in the series. == Setting == Much of the action in the series takes place on the planet Hyperion. It is described as having one-fifth less gravity than Earth standard. Hyperion has a number of peculiar indigenous flora and fauna, notably Tesla trees, which are essentially large electricity-spewing trees. It is also a "labyrinthine" planet, which means that it is home to ancient subterranean labyrinths of unknown purpose. Most importantly, Hyperion is the location of the Time Tombs, large artifacts surrounded by "anti-entropic" fields that allow them to move backward through time. In the fictional universe of the Hyperion Cantos, the Hegemony of Man encompasses over 200 planets. Faster than light communications technology, Fatlines, are said to operate through tachyon bursts. However, in later books it is revealed that they operate through the Void Which Binds. The Farcaster network was given to humanity by the TechnoCore and again it was another use of the Void Which Binds that allowed this instantaneous travel between worlds. The Hawking Drive was developed by human scientists, allowing the faster than light travel which led to the Hegira (from the Arabic word هجرة Hijra, meaning 'migration'). The Gideon drive, a Core-provided starship drive, allows for near-instantaneous travel between any two points in human-occupied space. The drive's use kills any human on board a Gideon-propelled starship; thus, the technology is only of use with remote probes or when used in conjunction with the Pax's resurrection technology. The resurrection creche can regenerate someone carrying a cruciform from their remains. Treeships are living trees that are propelled by ergs (spider-like solid-state alien being that emits force fields) through space. === The Shrike === The region of the Tombs is also the home of the Shrike, a menacing half-mechanical, half-organic four-armed creature that features prominently in the series. It appears in all four Hyperion Cantos books and is an enigma in the initial two; its purpose is not revealed until the second book, but is still left nebulous. The Shrike appears to act both autonomously and as a servant of some unknown force or entity. In the first two Hyperion books, it exists solely in the area around the Time Tombs on the planet Hyperion. Its portrayal is changed significantly in the last two books, Endymion and The Rise of Endymion. In these novels, the Shrike appears effectively unfettered and protects the heroine Aenea against assassins of the opposing TechnoCore. Surrounded in mystery, the object of fear, hatred, and even worship by members of the Church of the Final Atonement (the Shrike Cult), the Shrike's origins are described as uncertain. It is portrayed as composed of razorwire, thorns, blades, and cutting edges, having fingers like scalpels and long, curved toe blades. It has the ability to control the flow of time, and may thus appear to travel infinitely fast. The Shrike may kill victims in a flash or it may transport them to an eternity of impalement upon an enormous artificial 'Tree of Thorns,' or 'Tree of Pain' in Hyperion's distant future. The Tree of Thorns is described as an unimaginably large, metallic tree, alive with the agonized writhing of countless human victims of all ages and races. It is also hinted in the second book that the Tree of Thorns is actually a simulation generated by a mystical interface which connects to human brains via a strong and pulsing (as if it were alive) cord. The name Shrike seems a reference to birds of the shrike family, a family of birds that impales their victims on thorns, spines, or twigs. === Worlds and Systems === In the fictional universe of the Hyperion Cantos, the Hegemony of Man encompasses over 200 planets. The following planets appear or are specifically mentioned in the Hyperion Cantos. Planets of
Moral outsourcing
Moral outsourcing is the placing of responsibility for ethical decision-making onto external entities, often algorithms. The term is often used in discussions of computer science and algorithmic fairness, but it can apply to any situation in which one appeals to outside agents in order to absolve themselves of responsibility for their actions. In this context, moral outsourcing specifically refers to the tendency of society to blame technology, rather than its creators or users, for any harm it may cause. == Definition == The term "moral outsourcing" was first coined by Dr. Rumman Chowdhury, a data scientist concerned with the overlap between artificial intelligence and social issues. Chowdhury used the term to describe looming fears of a so-called “Fourth Industrial Revolution” following the rise of artificial intelligence. Moral outsourcing is often applied by technologists to shrink away from their part in building offensive products. In her TED Talk, Chowdhury gives the example of a creator excusing their work by saying they were simply doing their job. This is a case of moral outsourcing and not taking ownership for the consequences of creation. When it comes to AI, moral outsourcing allows for creators to decide when the machine is human and when it is a computer - shifting the blame and responsibility of moral plights off of the technologists and onto the technology. Conversations around AI and bias and its impacts require accountability to bring change. It is difficult to address these biased systems if their creators use moral outsourcing to avoid taking any responsibility for the issue. One example of moral outsourcing is the anger that is directed at machines for “taking jobs away from humans” rather than companies for employing that technology and jeopardizing jobs in the first place. The term "moral outsourcing" refers to the concept of outsourcing, or enlisting an external operation to complete specific work for another organization. In the case of moral outsourcing, the work of resolving moral dilemmas or making choices according to an ethical code is supposed to be conducted by another entity. == Real-world applications == In the medical field, AI is increasingly involved in decision-making processes about which patients to treat, and how to treat them. The responsibility of the doctor to make informed decisions about what is best for their patients is outsourced to an algorithm. Sympathy is also noted to be an important part of medical practice; an aspect that artificial intelligence, glaringly, is missing. This form of moral outsourcing is a major concern in the medical community. Another field of technology in which moral outsourcing is frequently brought up is autonomous vehicles. California Polytechnic State University professor Keith Abney proposed an example scenario: "Suppose we have some [troublemaking] teenagers, and they see an autonomous vehicle, they drive right at it. They know the autonomous vehicle will swerve off the road and go off a cliff, but should it?" The decision of whether to sacrifice the autonomous vehicle (and any passengers inside) or the vehicle coming at it will be written into the algorithms defining the car's behavior. In the case of moral outsourcing, the responsibility of any damage caused by an accident may be attributed to the autonomous vehicle itself, rather than the creators who wrote the protocol the vehicle will use to "decide" what to do. Moral outsourcing is also used to delegate the consequences of predictive policing algorithms to technology, rather than the creators or the police. There are many ethical concerns with predictive policing due to the fact that it results in the over-policing of low income and minority communities. In the context of moral outsourcing, the positive feedback loop of sending disproportionate police forces into minority communities is attributed to the algorithm and the data being fed into this system--rather than the users and creators of the predictive policing technology. == Outside of technology == === Religion === Moral outsourcing is also commonly seen in appeals to religion to justify discrimination or harm. In his book What It Means to be Moral, sociologist Phil Zuckerman contradicts the popular religious notion that morality comes from God. Religion is oftentimes cited as a foundation for a moral stance without any tangible relation between the religious beliefs and personal stance. In these cases, religious individuals will "outsource" their personal beliefs and opinions by claiming that they are a result of their religious identification. This is seen where religion is cited as a factor for political beliefs, medical beliefs, and in extreme cases an excuse for violence. === Manufacturing === Moral outsourcing can also be seen in the business world in terms of manufacturing goods and avoiding environmental responsibility. Some companies in the United States will move their production process to foreign countries with more relaxed environmental policies to avoid the pollution laws that exist in the US. A study by the Harvard Business Review found that "in countries with tight environmental regulation, companies have 29% lower domestic emissions on average. On the other hand, such a tightening in regulation results in 43% higher emissions abroad." The consequences of higher pollution rates are then attributed to the loose regulations in these countries, rather than on the companies themselves who purposefully moved into these areas to avoid strict pollution policy.
Artificial intelligence in pharmacy
Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.
A Very Fatal Murder
A Very Fatal Murder is a podcast produced by the satirical publication The Onion. A parody of true crime podcasts, A Very Fatal Murder is hosted by fictional New York City reporter David Pascall, who travels to the small town Bluff Springs, Nebraska to investigate the murder of prom queen Hayley Price. Pascall is voiced by David Sidorov, who also wrote for the podcast. The podcast premiered on January 23, 2018, and consists of 7 episodes. Season 2 was released in its entirety on May 11, 2019. == Production == A Very Fatal Murder satirizes popular true crime podcasts such as Serial, S-Town, and My Favorite Murder. According to head writer Katy Yeiser, the podcast is not meant as a take down of any particular podcast, but rather an ode to the genre. == Synopsis == The podcast follows fictional investigative reporter David Pascall (voiced by David Sidorov) who is searching for the perfect murder to create an award-winning podcast about. He is assisted by ETHL (the Extremely Timely Homicide Locator), an MIT-created computer programmed to find "the most interesting, violent, culturally relevant murder cases in America". == Episodes == === Season 1 === === Season 2 === == Reception == The podcast received mostly positive reviews, and was largely praised for attacking true-crime tropes such as the "hot dead girl" and the romanticization of small-town America. === Awards ===
International Conference on Automated Planning and Scheduling
The International Conference on Automated Planning and Scheduling (ICAPS) is a leading international academic conference in automated planning and scheduling held annually for researchers and practitioners in planning and scheduling. ICAPS is supported by the National Science Foundation, the journal Artificial Intelligence, and other supporters. == The IPC and PDDL == ICAPS conducts the International Planning Competition (IPC), a competition scheduled every few years that empirically evaluates state-of-the-art planning systems on a collection of benchmark problems. The Planning Domain Definition Language (PDDL) was developed mainly to make the 1998/2000 International Planning Competition possible, and then evolved with each competition. PDDL is an attempt to standardize Artificial Intelligence (AI) planning languages. PDDL was first developed by Drew McDermott and his colleagues in 1998, inspired by STRIPS, ADL, and other sources. == History == The ICAPS conferences began in 2003 as a merge of two bi-annual conferences, the International Conference on Artificial Intelligence Planning and Scheduling (AIPS) and the European Conference on Planning (ECP). == List of events ==
Acoustic model
An acoustic model is used in automatic speech recognition to represent the relationship between an audio signal and the phonemes or other linguistic units that make up speech. The model is learned from a set of audio recordings and their corresponding transcripts. It is created by taking audio recordings of speech, and their text transcriptions, and using software to create statistical representations of the sounds that make up each word. == Background == Modern speech recognition systems use both an acoustic model and a language model to represent the statistical properties of speech. The acoustic model models the relationship between the audio signal and the phonetic units in the language. The language model is responsible for modeling the word sequences in the language. These two models are combined to get the top-ranked word sequences corresponding to a given audio segment. Most modern speech recognition systems operate on the audio in small chunks known as frames with an approximate duration of 10ms per frame. The raw audio signal from each frame can be transformed by applying the mel-frequency cepstrum. The coefficients from this transformation are commonly known as mel-frequency cepstral coefficients (MFCCs) and are used as an input to the acoustic model along with other features. Recently, the use of convolutional neural networks has led to major improvements in acoustic modeling. == Speech audio characteristics == Audio can be encoded at different sampling rates (i.e. samples per second – the most common being: 8, 16, 32, 44.1, 48, and 96 kHz), and different bits per sample (the most common being: 8-bits, 16-bits, 24-bits or 32-bits). Speech recognition engines work best if the acoustic model they use was trained with speech audio which was recorded at the same sampling rate/bits per sample as the speech being recognized. == Telephony-based speech recognition == The limiting factor for telephony based speech recognition is the bandwidth at which speech can be transmitted. For example, a standard land-line telephone only has a bandwidth of 64 kbit/s at a sampling rate of 8 kHz and 8-bits per sample (8000 samples per second 8-bits per sample = 64000 bit/s). Therefore, for telephony based speech recognition, acoustic models should be trained with 8 kHz/8-bit speech audio files. In the case of voice over IP, the codec determines the sampling rate/bits per sample of speech transmission. Codecs with a higher sampling rate/bits per sample for speech transmission (which improve the sound quality) necessitate acoustic models trained with audio data that matches that sampling rate/bits per sample. == Desktop-based speech recognition == For speech recognition on a standard desktop PC, the limiting factor is the sound card. Most sound cards today can record at sampling rates of between 16–48 kHz of audio, with bit rates of 8- to 16-bits per sample, and playback at up to 96 kHz. As a general rule, a speech recognition engine works better with acoustic models trained with speech audio data recorded at higher sampling rates/bits per sample. But using audio with too high a sampling rate/bits per sample can slow the recognition engine down. A compromise is needed. Thus for desktop speech recognition, the current standard is acoustic models trained with speech audio data recorded at sampling rates of 16 kHz/16 bits per sample.
Hindsight optimization
Hindsight optimisation (HOP) is a computer science technique used in artificial intelligence for analysis of actions which have stochastic results. HOP is used in combination with a deterministic planner. By creating sample results for each of the possible actions from the given state (i.e. determinising the actions), and using the deterministic planner to analyse those sample results, HOP allows an estimate of the actual action.