GeneTalk is a web-based platform, tool, and database for filtering, reduction and prioritization of human sequence variants from next-generation sequencing (NGS) data. GeneTalk allows editing annotation about sequence variants and build up a crowd sourced database with clinically relevant information for diagnostics of genetic disorders. GeneTalk allows searching for information about specific sequence variants and connects to experts on variants that are potentially disease-relevant. == Application to diagnostics == Users can upload NGS data in Variant Call Format (VCF) onto the GeneTalk server into their accounts. All entries of the file are preprocessed and shown in the integrated VCF viewer. Filtering tools are set by the user to reduce the number of clinically non-relevant variants. After filtering and prioritization users can interpret relevant variants by retrieving information (annotations) about variants from the GeneTalk database. The communication platform allow users to contact experts about specific variants, genes, or genetic disorders, to exchange knowledge and expertise. === Analysis procedure === Steps required to analyze VCF files Upload VCF file Edit pedigree and phenotype information for segregation filtering Filter VCF file by editing the filtering options View results and annotations Add annotations === Filtering tools === The following filtering options may be used to reduce the non-relevant sequence variants in VCF files. Functional – filter out variants that have effects on protein level Linkage – filter out variants that are on specified chromosomes Gene panel – filter variants by genes or gene panels, subscribe to publicly available gene panels or create own ones Frequency – show only variants with a genotype frequency lower than specified Inheritance – filter out variants by presumed mode of inheritance Annotation – show only variants with a score for medical relevance and scientific evidence == Communication platform and expert network == Users can share VCF files with colleagues and coworkers. The integrated mailing systems allows users to contact experts easily. Users can create annotations and comments and rate annotations regarding medical relevance and scientific evidence, that is helpful for the community of users for diagnosis of genetic disorders. Registered users provide information about their field of knowledge in their profile and can be contacted by other users. == Potential applications == Developing diagnostics Genetic analysis Capturing data generated by community Communication and exchange of knowledge and expertise
Clipping (computer graphics)
Clipping, in the context of computer graphics, is a method to selectively enable or disable rendering operations within a defined region of interest. Mathematically, clipping can be described using the terminology of constructive geometry. A rendering algorithm only draws pixels in the intersection between the clip region and the scene model. Lines and surfaces outside the view volume (aka. frustum) are removed. Clip regions are commonly specified to improve render performance. Pixels that will be drawn are said to be within the clip region. Pixels that will not be drawn are outside the clip region. More informally, pixels that will not be drawn are said to be "clipped." == In 2D graphics == In two-dimensional graphics, a clip region may be defined so that pixels are only drawn within the boundaries of a window or frame. Clip regions can also be used to selectively control pixel rendering for aesthetic or artistic purposes. In many implementations, the final clip region is the composite (or intersection) of one or more application-defined shapes, as well as any system hardware constraints In one example application, consider an image editing program. A user application may render the image into a viewport. As the user zooms and scrolls to view a smaller portion of the image, the application can set a clip boundary so that pixels outside the viewport are not rendered. In addition, GUI widgets, overlays, and other windows or frames may obscure some pixels from the original image. In this sense, the clip region is the composite of the application-defined "user clip" and the "device clip" enforced by the system's software and hardware implementation. Application software can take advantage of this clip information to save computation time, energy, and memory, avoiding work related to pixels that aren't visible. == In 3D graphics == In three-dimensional graphics, the terminology of clipping can be used to describe many related features. Typically, "clipping" refers to operations in the plane that work with rectangular shapes, and "culling" refers to more general methods to selectively process scene model elements. This terminology is not rigid, and exact usage varies among many sources. Scene model elements include geometric primitives: points or vertices; line segments or edges; polygons or faces; and more abstract model objects such as curves, splines, surfaces, and even text. In complicated scene models, individual elements may be selectively disabled (clipped) for reasons including visibility within the viewport (frustum culling); orientation (backface culling), obscuration by other scene or model elements (occlusion culling, depth- or "z" clipping). Sophisticated algorithms exist to efficiently detect and perform such clipping. Many optimized clipping methods rely on specific hardware acceleration logic provided by a graphics processing unit (GPU). The concept of clipping can be extended to higher dimensionality using methods of abstract algebraic geometry. === Near clipping === Beyond projection of vertices & 2D clipping, near clipping is required to correctly rasterise 3D primitives; this is because vertices may have been projected behind the eye. Near clipping ensures that all the vertices used have valid 2D coordinates. Together with far-clipping it also helps prevent overflow of depth-buffer values. Some early texture mapping hardware (using forward texture mapping) in video games suffered from complications associated with near clipping and UV coordinates. === Occlusion clipping (Z- or depth clipping) === In 3D computer graphics, "Z" often refers to the depth axis in the system of coordinates centered at the viewport origin: "Z" is used interchangeably with "depth", and conceptually corresponds to the distance "into the virtual screen." In this coordinate system, "X" and "Y" therefore refer to a conventional cartesian coordinate system laid out on the user's screen or viewport. This viewport is defined by the geometry of the viewing frustum, and parameterizes the field of view. Z-clipping, or depth clipping, refers to techniques that selectively render certain scene objects based on their depth relative to the screen. Most graphics toolkits allow the programmer to specify a "near" and "far" clip depth, and only portions of objects between those two planes are displayed. A creative application programmer can use this method to render visualizations of the interior of a 3D object in the scene. For example, a medical imaging application could use this technique to render the organs inside a human body. A video game programmer can use clipping information to accelerate game logic. For example, a tall wall or building that occludes other game entities can save GPU time that would otherwise be spent transforming and texturing items in the rear areas of the scene; and a tightly integrated software program can use this same information to save CPU time by optimizing out game logic for objects that aren't seen by the player. == Algorithms == Line clipping algorithms: Cohen–Sutherland Liang–Barsky Fast-clipping Cyrus–Beck Nicholl–Lee–Nicholl Skala O(lg N) algorithm Polygon clipping algorithms: Greiner–Hormann Sutherland–Hodgman Weiler–Atherton Vatti Rendering methodologies Painter's algorithm
Dialogflow
Dialogflow is a natural language understanding platform used to design and integrate a conversational user interface into mobile apps, web applications, devices, bots, interactive voice response systems and related uses. == History == In May 2012, Speaktoit received a venture round (funding terms undisclosed) from Intel Capital. In July 2014, Speaktoit closed their Series B funding led by Motorola Solutions Venture Capital with participation from new investor Plug and Play Ventures and existing backers Intel Capital and Alpine Technology Fund. In September 2014, Speaktoit released api.ai (the voice-enabling engine that powers Assistant) to third-party developers, allowing the addition of voice interfaces to apps based on Android, iOS, HTML5, and Cordova. The SDK's contain voice recognition, natural language understanding, and text-to-speech. api.ai offers a web interface to build and test conversation scenarios. The platform is based on the natural language processing engine built by Speaktoit for its Assistant application. Api.ai allows Internet of Things developers to include natural language voice interfaces in their products. Assistant and Speaktoit's websites now redirect to api.ai's website Archived 2017-10-10 at the Wayback Machine, which redirects to the Dialogflow website. Google bought the company in September 2016 and was initially known as API.AI; it provides tools to developers building apps ("Actions") for the Google Assistant virtual assistant. The organization discontinued the Assistant app on December 15, 2016. In October 2017, it was renamed as Dialogflow. In November 2017, Dialogflow became part of Google Cloud Platform.
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EPUAP
ePUAP (Electronic Platform of Public Administration Services) is a Polish nationwide platform for communication of citizens with public administrations in a uniform and standardized way. Built as part of the ePUAP-WKP project (State Informatization Plan). Service providers are public administration units and public institutions (especially entities that perform tasks commissioned by the state). The platform provides service providers with technological infrastructure to provide services to citizens (recipients). Among the participants of ePUAP there are both central administration units and local governments, including municipal offices. Among the services offered by ePUAP is also Profil Zaufany (Trusted Profile), which enables electronic filing with legal effect without the need to use a qualified signature and SAML-based single sign-on mechanism, which enables the same ePUAP account to log on to websites of various service providers. The website www.epuap.gov.pl enables defining citizen and businesses service processes, creates channels of access to different systems of public administration and extends the package of public services provided electronically. Services available through the ePUAP platform may be accessed at the official website. Currently all administration services are available in Polish only. == Overview == It is described by the Polish government as "a coherent and systematic action program designed and developed to allow public institutions make their electronic services available to the public". The platform provides citizens, businesses and institutions with a number of services intended to ensure smooth and safe communication between: customer to administrations (C2A), business to administration (B2A), administration to administration (A2A). === Main goals === The main project objectives are to create a single, secure and electronic access channel to public services for citizens, businesses and public administration and also to reduce time and lower the costs of sharing information resources and functionalities of administration domain systems. Within the project, the following functionalities and services were delivered: Public services catalogue – a method of presenting and describing administration services, ePUAP platform – a web platform designed to provide public services on the Internet, Interoperability portal – a portal for experts working on recommendations for electronic documents and forms used within Polish administration systems to assure the uniformity of IT standards, Central Repository of Electronic Document Models – a database for valid document models and electronic forms. == History and background == The ePUAP project was carried out in the years 2005–2008. Currently, a continuation project ePUAP2 is being carried out with the following objectives: to increase the number of online services available to the public including the registry services, to widen the scale of usage of public electronic services, to integrate subsequent systems of public administration and business on ePUAP portal, to define new processes of customer and business services. === ePUAP2 === ePUAP2 is a public and administrative project that extends the set of functional services developed during the first edition of the project and is another step in the process of transforming Poland into a modern and citizen-friendly country. The implementation period for the project covers the years 2009–2013. Project financing The cost of the project “Construction of electronic Platform of Public Administration Services” – 32 million PLN was covered in 75% by the funds from the European Regional Development Fund (under the Sector Operational Programme "Supporting Competitiveness of Enterprises for the years 2004–2006"), while the remaining 25% of the cost was covered by a Polish national co-financing. Funds for the ePUAP2 project were gained from the 7th priority axis of the Innovative Economy Operational Programme and amounts to 140 million PLN (85% of eligible expenses were covered by the European Regional Development Fund, 15% were covered by a national co-financing). The trustee of ePUAP is the Polish Ministry of the Interior and Administration. == Legal regulations == According to the Polish law from 1 May 2008, public authorities are required to accept documents in electronic form (bringing applications and proposals and other activities in electronic form). ePUAP enables public institutions to meet this requirement by providing a service infrastructure to set up am electronic inbox. The ePUAP inbox meets legal requirements, in particular: issuing an official confirmation of receipt in accordance with the regulation of the Prime Minister of 29 September 2005 on the organizational and technical conditions for the delivery of electronic documents to public entities; cooperation with hardware security modules (HSM), meeting the technical requirements set out in the law; handling documents electronically in accordance with the minimum requirements set out in the Regulation of the Polish Council of Ministers of 11 October 2005 on minimum requirements for ICT systems. == Incidents == === Crashes === The ePUAP system very often happens smaller or larger failures. Because it is used to sign the application profiles trusted also in other electronic systems such as public administration. Electronic Services Platform created by ZUS, the system fault ePUAP it very difficult to settle official matters most electronically. === "Infoafera" === According to TVN and the release of TVP News from 10 April 2014, the creation of ePUAP is also associated with the so-called "Infoafera." On 10 April 2014, the Minister of Internal Affairs of Poland confirmed the information that the American technology company HP confessed to its participation in the Polish info-tour and corruption of Polish officials. By March 2014, the construction of ePUAP and its maintenance cost PLN 98.4 million. PLN 67.8 million has been used for this project. Challenged expenses only on the portal itself is approx. PLN 20 million.
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