A.L.I.C.E. (Artificial Linguistic Internet Computer Entity), also referred to as Alicebot, or simply Alice, is a natural language processing chatbot—a program that engages in a conversation with a human by applying some heuristical pattern matching rules to the human's input. It was inspired by Joseph Weizenbaum's classical ELIZA program. It is one of the strongest programs of its type and has won the Loebner Prize, awarded to accomplished humanoid, talking robots, three times (in 2000, 2001, and 2004). The program is unable to pass the Turing test, as even the casual user will often expose its mechanistic aspects in short conversations. Alice was originally composed by Richard Wallace; it "came to life" on November 23, 1995. The program was rewritten in Java beginning in 1998. The current incarnation of the Java implementation is Program D. The program uses an XML Schema called AIML (Artificial Intelligence Markup Language) for specifying the heuristic conversation rules. Alice code has been reported to be available as open source. The AIML source is available from ALICE A.I. Foundation on Google Code and from the GitHub account of Richard Wallace. These AIML files can be run using an AIML interpreter like Program O or Program AB. == In popular culture == Spike Jonze has cited ALICE as the inspiration for his academy award-winning film Her, in which a human falls in love with a chatbot. In a New Yorker article titled “Can Humans Fall in Love with Bots?” Jonze said “that the idea originated from a program he tried about a decade ago called the ALICE bot, which engages in friendly conversation.” The Los Angeles Times reported:Though the film’s premise evokes comparisons to Siri, Jonze said he actually had the idea well before the Apple digital assistant came along, after using a program called Alicebot about ten years ago. As geek nostalgists will recall, that intriguing if at times crude software (it flunked the industry-standard Turing Test) would attempt to engage users in everyday chatter based on a database of prior conversations. Jonze liked it, and decided to apply a film genre to it. “I thought about that idea, and what if you had a real relationship with it?” Jonze told reporters. “And I used that as a way to write a relationship movie and a love story.”
List of performance analysis tools
This is a list of performance analysis tools for use in software development. == General purpose, language independent == The following tools work based on log files that can be generated from various systems. time (Unix) - can be used to determine the run time of a program, separately counting user time vs. system time, and CPU time vs. clock time. timem (Unix) - can be used to determine the wall-clock time, CPU time, and CPU utilization similar to time (Unix) but supports numerous extensions. Supports reporting peak resident set size, major and minor page faults, priority and voluntary context switches via getrusage. Supports sampling procfs on supporting systems to report metrics such as page-based resident set size, virtual memory size, read-bytes, and write-bytes, etc. Supports collecting hardware counters when built with PAPI support. == Multiple languages == The following tools work for multiple languages or binaries. == C and C++ == Arm MAP, a performance profiler supporting Linux platforms. AppDynamics, an application performance management service for C/C++ applications via SDK. AQtime Pro, a performance profiler and memory allocation debugger that can be integrated into Microsoft Visual Studio, and Embarcadero RAD Studio, or can run as a stand-alone application. IBM Rational Purify was a memory debugger allowing performance analysis. Instruments (bundled with Xcode) is used to profile an executable's memory allocations, time usage, filesystem activity, GPU activity etc. Intel Parallel Studio contains Intel VTune Amplifier, which tunes both serial and parallel programs. It also includes Intel Advisor and Intel Inspector. Intel Advisor optimizes vectorization (use of SIMD instructions) and prototypes threading implementations. Intel Inspector detects and debugs races, deadlocks and memory errors. Parasoft Insure++ provides a graphical tool that displays and animates memory allocations in real time to expose memory blowout, fragmentation, overuse, bottlenecks and leaks. Visual Studio Team System Profiler, commercial profiler by Microsoft. == Java == inspectIT is an open-source application performance management (APM) service for monitoring and analyzing software applications, available under the Apache License, Version 2.0 (ALv2). JConsole is the profiler which comes with the Java Development Kit JProfiler JRockit Mission Control, a profiler with low overhead. Netbeans Profiler, a profiler integrated into the NetBeans IDE (internally uses jvisualvm profiler) Plumbr, Java application performance monitoring with automated root cause detection. Links memory leaks, GC inefficiency, slow database and external web service calls, locked threads, and other performance problems to the line in source code that causes them. OverOps, Continuous reliability for the modern software supply chain, automatically detect and deliver root cause automation for all errors. VisualVM is a visual tool integrating several commandline JDK tools and lightweight profiling capabilities. It is bundled with the Java Development Kit since version 6, update 7. == JavaScript == The Firefox web browser's developer tools contain a Performance tool, which gives insight into JavaScript performance of a website. Microsoft Visual Studio AJAX Profiling Extensions is a free profiling tool for JavaScript by Microsoft Research. == .NET == CLR Profiler is a free memory profiler provided by Microsoft for CLR applications. GlowCode is a performance and memory profiler for .NET applications using C# and other .NET languages. It identifies time-intensive functions and detects memory leaks and errors in native, managed and mixed Windows x64 and x86 applications. Visual Studio == PHP == BlackFire.io Dbg Xdebug is a PHP extension which provides debugging and profiling capabilities.
Gollum browser
Gollum browser is a discontinued web browser for accessing Wikipedia. Since 2017, Gollum is no longer accessible online. Gollum is designed to browse Wikipedia in an easier way than directly using the web browser. Links external to Wikipedia are opened in the user's regular browser. Gollum is opened from a regular browser and makes a window that puts the Wikipedia search bar on the toolbar. Gollum was created by Harald Hanek in 2005 using PHP and Ajax. According to one blogger, Gollum provides a way to bypass censorship of Wikipedia in China. == Languages == Though the website is available only in English and German, Gollum's GUI is available in more than 32 languages and can browse nearly 50 Wikipedia editions. === Gollum's GUI === === Browsable Wikipedia editions ===
Summify
Summify was a social news aggregator founded by Mircea Paşoi and Cristian Strat, two former Google and Microsoft interns from Romania. The service emailed its users a periodic summary of news articles shared from their social networks based on their relevance and importance. The platform supported Twitter, Facebook, and Google Reader accounts. == History == In 2009, Paşoi and Strat created ReadFu, a plugin that provided a contextual summary and statistics of the target page of a hyperlink. In January 2010, ReadFu was accepted into the Vancouver-based start-up incubator Bootup Labs. On March 20, 2010 the service was renamed to Summify and a private beta began. On August 11, 2010 Paşoi and Strat announced a new direction for the service. It would become a real-time social news reader that aggregates incoming news from social networks and displays articles by importance using social reactions. After some feedback that the users preferred article digests by email more than the real-time news reader version, Summify discontinued the news reader version. In March 2011, Summify completed a Seed round, with investors including Rob Glaser, Accel Partners, and Stewart Butterfield. Summify received coverage from various news and media outlets such as TechCrunch. It was also featured in various news platforms, such as Time, The Globe and Mail, Mashable, VentureBeat, Gizmodo, Lifehacker, and The Next Web. Summify released a free app on the Apple App Store on July 8, 2011. The app allowed users to read their web summaries from iOS mobile devices. Summify was acquired by Twitter on January 19, 2012. The service shut down soon after, on June 22, 2012.
Biomedical data science
Biomedical data science is a multidisciplinary field which leverages large volumes of data to promote biomedical innovation and discovery. Biomedical data science draws from various fields including Biostatistics, Biomedical informatics, and machine learning, with the goal of understanding biological and medical data. It can be viewed as the study and application of data science to solve biomedical problems. Modern biomedical datasets often have specific features which make their analyses difficult, including: Large numbers of feature (sometimes billions), typically far larger than the number of samples (typically tens or hundreds) Noisy and missing data Privacy concerns (e.g., electronic health record confidentiality) Requirement of interpretability from decision makers and regulatory bodies Many biomedical data science projects apply machine learning to such datasets. These characteristics, while also present in many data science applications more generally, make biomedical data science a specific field. Examples of biomedical data science research include: Computational genomics Computational imaging Electronic health records data mining Biomedical network science Clinical Natural Language Processing (NLP) == Computational Imaging and Deep Learning == Computational imaging is a cornerstone of biomedical data science, focusing on the development of algorithms to enhance, analyze, and interpret medical imagery. In recent years, the field has been transformed by the integration of deep learning, particularly through the use of Convolutional Neural Networks. Deep learning started from researchers manually defining characteristics like edge detection or texture representation learning. In a more modern approach of computational imaging, models automatically learn a hierarchy of features directly from raw pixel data. This overlap between data science and deep learning is applied across several key tasks: Classification: Identifying the presence of specific diseases, such as distinguishing between benign and malignant tumors in histopathology slides or detecting pneumonia in chest X-rays. Segmentation: The precise delineation of anatomical structures or lesions. A notable example is the U-Net architecture, which is widely used for biomedical image segmentation to help clinicians quantify organ volume or track tumor growth. Detection: Automating the localization of small objects, such as identifying microcalcifications in mammograms or polyps during colonoscopies. Registration: The process of aligning multiple images to provide a comprehensive view of the patient's anatomy. Even with all of these enhancements, the application of deep learning in medical imaging requires accomplishing vigorous challenges. An example of these changes is building large, annotated datasets and creating the imperative for model interpretability in clinical decision-making. == Electronic Health Records == Electronic Health Records (EHRs) are a digital alternative to patient paper charts, usually including individual records or population health information. EHRs can be used in a wide variety of applications, including research and analysation as they often include demographics, diagnoses, medications, test results, and personal statistics. === History === ==== 1960s ==== The earliest precursor is considered Dr. Lawrence Weed's problem-oriented medical record (POMR) published in the 1968 which sorts and groups medical records by medical diagnoses and symptoms. The POMR was the first system to organize based off of patient information rather than the source (doctors, nurses, attendings, etc.). In 1969, the Regenstrief Institute developed and published the Regenstrief Medical Record System which established electronic writing, storage, and retrieval of records which served as the basis for modern EHR systems. ==== 2000s ==== In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH Act) was passed in the United States. This act standardized privacy and distribution of EHRs and increased the acceptance and utilization of EHRs within medical and academic settings. == Artificial Intelligence and Machine Learning Applications == Machine Learning and Artificial Intelligence have become central tools in biomedical data science. Recent advances in large language models (LLMs) have expanded their role beyond text, with models trained directly on genomic sequences enabling tasks such as gene function prediction, variant effect analysis, and drug discovery. In clinical settings, Natural Language Processing (NLP) models are applied to electronic health records to extract structured insights from unstructured clinical notes and data, supporting diagnosis and treatment planning. Beyond genomics, AI models have been applied to protein structure prediction. AlphaFold, developed by Google DeepMind, uses deep learning to predict three-dimensional protein structures from amino acid sequences with high accuracy. These predictions have been used to support drug target identification and the study of disease mechanisms. == Knowledge Graphs == Knowledge graphs (KGs) are widely used in biomedical data science to represent and analyze complex relationships among biological and medical entities. By structuring data as nodes (e.g., genes, diseases, drugs) and edges (relationships), KGs enable computational methods to extract insights and support decision-making. These biomedical relationships can be efficiently modeled and queried using technologies such as Neo4j. === Biomedical Research Applications === KGs provide biomedical researchers with a way to model complex biological systems. They have been used to identify the relationships between diseases and biomolecules, support drug repurposing, and to uncover new biological insights. Additional applications include: Identification of novel antibiotic resistance genes through graph-based link prediction. Finding associations between miRNA and diseases. Prediction of protein-protein interactions. === Clinical Applications === In clinical settings, KGs can be used to make visual representations of a patient's electronic health records. The data obtained from these graphs can assist healthcare providers in improving patient diagnoses and prescribing more effective drugs. Additionally, embeddings derived from resources like the Unified Medical Language System (UMLS) enable natural language processing of clinical text and similarity analysis between medical concepts. === Limitations === Despite their advantages, knowledge graphs face several challenges. Some of these include: High algorithmic complexity and large biological datasets make the process computationally expensive. KG construction can be a time-consuming process that requires careful attention to assign appropriate node types and vocabularies. Using data from a wide range of datasets in one KG requires them to be effectively integrated. == Privacy == A primary challenge in biomedical data science is maintaining medical privacy. Conducting research requires that data be collected on a number of people for training and testing purposes and is stored within biomedical datasets. This poses a risk for violating patient confidentiality and may dissuade people from participating in studies. The main sources of health statistics are surveys administrative and medical records health care claims data, vital records surveillance disease registries grey literature and peer-reviewed literature. Large data collection is a useful tool for researching various medical conditions. Researchers use these large datasets of information to identify factors that may make people more susceptible to certain diseases. Large amounts of collected data can help researchers identify patterns for disease probabilities. The findings can show a person is more likely for a condition, or identify environmental, social, and personal habits that may lead to adverse health issues. Institutions researching using personal medical information come with a moral and legal responsibility to protect the use of that information. Protection of the collected information has become a big concern. Sophisticated and coordinated attacks on certain medical systems happen more frequently. Medical companies, medical insurance and private businesses have invested a great deal into the protection of personal data. Despite this, data breaches continue to be documented. The chart below shows the top healthcare breaches in 2025. For these reasons, many people have reservations about giving up their personal data. Aside from the legitimate use of personal data there have been instances where companies have found methods to profit from brokering medical information. Concerns exist regarding unauthorized use of sensitive information within these data companies. If a person is identified within a dataset, then sensitive data can be used to discriminate against them. For example, insurance companies may charge a hi
Once (dating platform)
Once is an online dating platform founded in 2015. The platform offers users one selected match per day for more meaningful connections. == History == Once was established in 2015, the founders included dating industry entrepreneur Jean Meyer, who became a CEO of the company, as well as Guillaume Sempe and Guilhem Duche. It focused on providing a single daily match to its users. On its early stages Once secured a $3.5 million seed round from Partech Ventures and some private investors. The same year, it opened offices in Paris, and London. By 2016, it reached 1 million users. In 2020, the company was acquired by Dating Group for $18 million. Following the acquisition, Once underwent rebranding. Alexandra Beaumont took over leadership of the brand in 2021, driving growth, rebranding, and innovation. == Overview == Once provides an online dating service with a focus on thoughtful connections. Users receive one selected match per day, which encourages meaningful interactions. The platform operates primarily in the United States, the United Kingdom, Canada, France, and Spain. The platform is supported by Android, iOS, and Apple Watch OS.
WikiTok
WikiTok is a web application that shows random Wikipedia articles in an infinite scrolling format similar to TikTok. Created by New York-based civil and software engineer Isaac Gemal in February 2025, the application aims to provide an "anti-algorithmic" alternative to traditional social media platforms while combating doomscrolling. == Development == WikiTok was developed on February 3, 2025, after Gemal saw a viral tweet from developer Tyler Angert proposing "all of wikipedia on a single, scrollable page". Gemal created the initial prototype in approximately two hours, using the Claude LLM and Cursor coding editor, completing it by 2 a.m. that same night. The application was built with React 18, TypeScript, Tailwind CSS, and Vite, consisting of only a few hundred lines of code with no backend infrastructure. Gemal has made the project open-source, with the code publicly available on GitHub. == Functionality == WikiTok serves users completely random Wikipedia article snippets from Wikipedia's nearly 9.5 million entries. Each article preview includes a full-screen image from Wikipedia and a short text excerpt. Users can click "Read More" to access the full Wikipedia article, or continue scrolling to see the next random entry. The application functions as a progressive web app that can be downloaded as a hybrid between an app and a website. It works on both mobile and desktop browsers, and is designed to be responsive whether users scroll with their thumb on mobile devices or use a cursor on desktop computers. As of 2025, WikiTok supports 14 different languages for article translation. == Philosophy == Gemal has explicitly positioned WikiTok as "anti-algorithmic," resisting numerous requests to implement personalized content algorithms. In an interview with Business Insider, Gemal stated: "I have had plenty of people message me and even make issues on my GitHub asking for some insane crazy WikiTok algorithm... we're already ruled by ruthless, opaque algorithms in our everyday life; why can't we just have one little corner in the world without them?" The application aims to combat "doomscrolling" – the practice of mindlessly consuming negative news online that can cause anxiety, helplessness, and anger. Unlike traditional social media platforms, WikiTok deliberately excludes algorithms, advertisements, and user tracking.