Commission on Enhancing National Cybersecurity

Commission on Enhancing National Cybersecurity

The President's Commission on Enhancing National Cybersecurity is a Presidential Commission formed on April 13, 2016, to develop a plan for protecting cyberspace, and America's economic reliance on it. The commission released its final report in December 2016. The report made recommendations regarding the intertwining roles of the military, government administration and the private sector in providing cyber security. Chairman Donilon said of the report that its coverage "is unusual in the breadth of issues" with which it deals. == Recommendations == The report made sixteen major recommendations with fifty-three specific action items broadly grouped under six areas: Protecting the information and digital infrastructure Investing in the secure growth of information and digital infrastructure Consumer information access Building the cybersecurity workforce Building a secure governmental cybersecurity framework Keeping interconnectivity open, fair, competitive, and secure The Commission found that strong authentication systems were mandatory for adequate cybersecurity, not just for the government, but for all commercial systems, and private individuals. The commission also stressed remote identity proofing and security for the Internet of things (IoT). Finding that technicians who know cybersecurity and can protect systems are few and in short supply, the commission recommended nationally supported training programs to produce an adequate workforce, as well as increasing the level of expertise in the existing workforce. The Commission highlighted the importance of partnerships between government and the private sector as a powerful tool for encouraging the technology, policies and practices we need to secure and grow the digital economy. (page 2) Some criticised the commission's work as lacking an understanding of cybersecurity and not being cognizant of "cyber reality" and the cost of some of the action items, but others found the report constructive and meaningful. == Commission members == The initial members of the Commission are: Tom Donilon, former Assistant to the President and National Security Advisor (Chair) Sam Palmisano, former CEO of IBM (Vice Chair) General Keith Alexander, CEO of IronNet Cybersecurity, former Director of the National Security Agency and former Commander of U.S. Cyber Command Annie Antón, Professor and Chair of the School of Interactive Computing at Georgia Tech. Ajay Banga, President and CEO of MasterCard Steven Chabinsky, General Counsel and Chief Risk Officer of CrowdStrike Patrick Gallagher, Chancellor of the University of Pittsburgh and former Director of the National Institute of Standards and Technology Peter Lee, Corporate Vice President, Microsoft Research Herbert Lin, Senior Research Scholar for Cyber Policy and Security at the Stanford Center for International Security and Cooperation and Research Fellow at the Hoover Institution Heather Murren, former member of the Financial Crisis Inquiry Commission and co-founder of the Nevada Cancer Institute Joe Sullivan, Chief Security Officer of Uber and former Chief Security Officer of Facebook Maggie Wilderotter, Executive Chairman of Frontier Communications == Follow-on == Incoming President Trump has indicated that he wants a full review of U.S. cyber protection policy. == Notes and references ==

Hyperparameter optimization

In machine learning, hyperparameter optimization or tuning is the problem of choosing a set of optimal hyperparameters for a learning algorithm. A hyperparameter is a parameter whose value is used to control the learning process, which must be configured before the process starts. Hyperparameter optimization determines the set of hyperparameters that yields an optimal model which minimizes a predefined loss function on a given data set. The objective function takes a set of hyperparameters and returns the associated loss. Cross-validation is often used to estimate this generalization performance, and therefore choose the set of values for hyperparameters that maximize it. == Approaches == === Grid search === The traditional method for hyperparameter optimization has been grid search, or a parameter sweep, which is simply an exhaustive searching through a manually specified subset of the hyperparameter space of a learning algorithm. A grid search algorithm must be guided by some performance metric, typically measured by cross-validation on the training set or evaluation on a hold-out validation set. Since the parameter space of a machine learner may include real-valued or unbounded value spaces for certain parameters, manually set bounds and discretization may be necessary before applying grid search. For example, a typical soft-margin SVM classifier equipped with an RBF kernel has at least two hyperparameters that need to be tuned for good performance on unseen data: a regularization constant C and a kernel hyperparameter γ. Both parameters are continuous, so to perform grid search, one selects a finite set of "reasonable" values for each, say C ∈ { 10 , 100 , 1000 } {\displaystyle C\in \{10,100,1000\}} γ ∈ { 0.1 , 0.2 , 0.5 , 1.0 } {\displaystyle \gamma \in \{0.1,0.2,0.5,1.0\}} Grid search then trains an SVM with each pair (C, γ) in the Cartesian product of these two sets and evaluates their performance on a held-out validation set (or by internal cross-validation on the training set, in which case multiple SVMs are trained per pair). Finally, the grid search algorithm outputs the settings that achieved the highest score in the validation procedure. Grid search suffers from the curse of dimensionality, but is often embarrassingly parallel because the hyperparameter settings it evaluates are typically independent of each other. === Random search === Random Search replaces the exhaustive enumeration of all combinations by selecting them randomly. This can be simply applied to the discrete setting described above, but also generalizes to continuous and mixed spaces. A benefit over grid search is that random search can explore many more values than grid search could for continuous hyperparameters. It can outperform Grid search, especially when only a small number of hyperparameters affects the final performance of the machine learning algorithm. In this case, the optimization problem is said to have a low intrinsic dimensionality. Random Search is also embarrassingly parallel, and additionally allows the inclusion of prior knowledge by specifying the distribution from which to sample. Despite its simplicity, random search remains one of the important base-lines against which to compare the performance of new hyperparameter optimization methods. === Bayesian optimization === Bayesian optimization is a global optimization method for noisy black-box functions. Applied to hyperparameter optimization, Bayesian optimization builds a probabilistic model of the function mapping from hyperparameter values to the objective evaluated on a validation set. By iteratively evaluating a promising hyperparameter configuration based on the current model, and then updating it, Bayesian optimization aims to gather observations revealing as much information as possible about this function and, in particular, the location of the optimum. It tries to balance exploration (hyperparameters for which the outcome is most uncertain) and exploitation (hyperparameters expected close to the optimum). In practice, Bayesian optimization has been shown to obtain better results in fewer evaluations compared to grid search and random search, due to the ability to reason about the quality of experiments before they are run. === Gradient-based optimization === For specific learning algorithms, it is possible to compute the gradient with respect to hyperparameters and then optimize the hyperparameters using gradient descent. The first usage of these techniques was focused on neural networks. Since then, these methods have been extended to other models such as support vector machines or logistic regression. A different approach in order to obtain a gradient with respect to hyperparameters consists in differentiating the steps of an iterative optimization algorithm using automatic differentiation. A more recent work along this direction uses the implicit function theorem to calculate hypergradients and proposes a stable approximation of the inverse Hessian. The method scales to millions of hyperparameters and requires constant memory. In a different approach, a hypernetwork is trained to approximate the best response function. One of the advantages of this method is that it can handle discrete hyperparameters as well. Self-tuning networks offer a memory efficient version of this approach by choosing a compact representation for the hypernetwork. More recently, Δ-STN has improved this method further by a slight reparameterization of the hypernetwork which speeds up training. Δ-STN also yields a better approximation of the best-response Jacobian by linearizing the network in the weights, hence removing unnecessary nonlinear effects of large changes in the weights. Apart from hypernetwork approaches, gradient-based methods can be used to optimize discrete hyperparameters also by adopting a continuous relaxation of the parameters. Such methods have been extensively used for the optimization of architecture hyperparameters in neural architecture search. === Evolutionary optimization === Evolutionary optimization is a methodology for the global optimization of noisy black-box functions. In hyperparameter optimization, evolutionary optimization uses evolutionary algorithms to search the space of hyperparameters for a given algorithm. Evolutionary hyperparameter optimization follows a process inspired by the biological concept of evolution: Create an initial population of random solutions (i.e., randomly generate tuples of hyperparameters, typically 100+) Evaluate the hyperparameter tuples and acquire their fitness function (e.g., 10-fold cross-validation accuracy of the machine learning algorithm with those hyperparameters) Rank the hyperparameter tuples by their relative fitness Replace the worst-performing hyperparameter tuples with new ones generated via crossover and mutation Repeat steps 2-4 until satisfactory algorithm performance is reached or is no longer improving. Evolutionary optimization has been used in hyperparameter optimization for statistical machine learning algorithms, automated machine learning, typical neural network and deep neural network architecture search, as well as training of the weights in deep neural networks. === Population-based === Population Based Training (PBT) learns both hyperparameter values and network weights. Multiple learning processes operate independently, using different hyperparameters. As with evolutionary methods, poorly performing models are iteratively replaced with models that adopt modified hyperparameter values and weights based on the better performers. This replacement model warm starting is the primary differentiator between PBT and other evolutionary methods. PBT thus allows the hyperparameters to evolve and eliminates the need for manual hypertuning. The process makes no assumptions regarding model architecture, loss functions or training procedures. PBT and its variants are adaptive methods: they update hyperparameters during the training of the models. On the contrary, non-adaptive methods have the sub-optimal strategy to assign a constant set of hyperparameters for the whole training. === Early stopping-based === A class of early stopping-based hyperparameter optimization algorithms is purpose-built for large search spaces of continuous and discrete hyperparameters, particularly when the computational cost to evaluate the performance of a set of hyperparameters is high. Irace implements the iterated racing algorithm, that focuses the search around the most promising configurations, using statistical tests to discard the ones that perform poorly. Another early stopping hyperparameter optimization algorithm is successive halving (SHA), which begins as a random search but periodically prunes low-performing models, thereby focusing computational resources on more promising models. Asynchronous successive halving (ASHA) further improves upon SHA's resource utilization profile by removing the need to synchronously evaluate a

Cortica

Headquartered in Tel Aviv Cortica utilizes unsupervised learning methods to recognize and analyze digital images and video. The technology developed by the Cortica team is based on research of the function of the human brain. == Company Founding == Cortica was founded in 2007 by Igal Raichelgauz, Karina Odinaev and Yehoshua Zeevi. Together, the founders developed the company’s core technology while at Technion – Israel Institute of Technology. By combining discoveries in neuroscience with developments in computer programming, the team created technology that possesses the ability to interpret large amounts of visual data with increased accuracy. This technology, called Image2Text, is based on the founders’ work in digitally replicating cortical neural networks’ ability to identify complex patterns within massive quantities of ambiguous and noisy data. Cortica’s offerings have application in the automotive industry, media industries, as well as the smart city and medical industries. Industry experts suggest that the self-driving automotive industry alone will be worth upwards of $7 trillion while each connected car is expected to generate 4,000 GB of data per day. Beyond that, industry analysts expect the proliferation of surveillance cameras to continue leading to an expected 2,500 Petabytes of data being generated daily by new surveillance cameras. Cortica operates in these high scale industries. The company currently employs professionals from many domains including AI researchers as well as veterans of intelligence units within the Israeli Defense Forces. == Research and Technology == In 2006, Founders Raichelgauz, Odinaev, and Zeevi shared their findings with the 28th IEEE EMBS Annual International Conference in New York in a paper titled, “Natural Signal Classification by Neural Cliques and Phase-Locked Attractors”. That same year, the team also published “Cliques in Neural Ensembles as Perception Carriers" CB Insights recently identified Cortica as the number one patent holder among AI companies. Cortica is researching to develop a machine-learning driving system which can identify objects and pedestrians. Connecting to it, Elon Musk has been rumored to partner with Cortica for his electric car company, Tesla. However, Tesla denies it stating that Musk did not discuss a collaboration with artificial intelligence firm Cortica. == Funding == Cortica raised $7 million in its Series A funding round, announced in August 2012. Investors included Horizons Ventures (the investment firm of Hong Kong billionaire Li Ka-Shing), and Ynon Kreiz, the former chairman and CEO of the Endemol Group. In May 2013, it was announced that Cortica had raised $1.5 million from Russian firm Mail.ru Group. It later transpired that this was a part of Cortica's Series B funding round for $6.4 million, announced in June 2013. The round was led by Horizons Ventures, with participation from the Russian firm Mail.ru Group and other angel investors. In its fourth funding round, Cortica has raised $20 million, bringing the total investments to $38 million. According to a report from The Israeli lead Daily economic newspaper, TheMarker, the fourth round was led by a strategic Chinese investor who will probably help the company expand into the Asian market. == Media coverage == GigaOm listed Cortica as one of the top deep learning startups in a November 2013 article surveying the field, along with AlchemyAPI, Ersatz, and Semantria. Business Insider ranked Cortica as one of the coolest tech companies in Israel. CB Insights has identified Cortica as the top patent holding AI company. In 2017 several leading automotive media outlets covered the launch of Cortica's automotive business unit

Texas Senate Bill 20

Texas Senate Bill 20 (S.B. 20), also known as the "Stopping AI-Generated Child Pornography Act", is a 2025 law in the state of Texas that creates new criminal offenses for those who possess, promote, or view visual material deemed obscene, which is said to depict a child, whether it is an actual person, animated or cartoon depiction, or an image of someone created through computer software or artificial intelligence. It was passed by the Texas Legislature on May 28, 2025, unanimously in both chambers. It was signed into law by Governor Greg Abbott on June 20, 2025. It went into effect on September 1, 2025. It was authored by Pete Flores and co-sponsored by Brent Hagenbuch, Juan Hinojosa, Joan Huffman, Phil King, and Tan Parker, as part of a package of legislation in the Texas House and Senate about A.I. and child pornography. Some supporters called it "common-sense" legislation falling within the "proper role" of government, protecting children and the "common good" within the state, with Heidi Ruiz, a police sergeant in Houston, describing the bill as "fantastic" and "fabulous." The bill drew comparisons to language, within Texas state legislation, which aimed to institute state-level book bans. Critics described the law as unconstitutional, saying it violated the Free Speech Clause of the First Amendment which prohibits abridgement of freedom of speech and the press, including the legal precedent set in Ashcroft v. Free Speech Coalition. The Comic Book Legal Defense Fund vowed to support those wrongly accused under the law. Much of the controversy regarding S.B. 20 involves the broad language pertaining to "obscene" pornographic images as including A.I.-created, animated, and cartoon depictions, with some critics arguing it could have a chilling effect on anime, manga, graphic novels, and other media produced, distributed, or created within Texas. == Provisions == S.B. 20 gives Texas police more provisions to restrict artificial intelligence-created child pornography, creating new criminal charge for possessing material depicting an underage person, under age 18, whether this child is an actual person or not. Those charged with this felony offense could go to state jail, but this could be elevated if the person charged has a prior conviction, of a $10,000 fine and two years in prison. == Reactions == === Support === Lieutenant Governor Dan Patrick applauded the unanimous passage of the law in the Texas Senate and called it "a priority" to protect children in Texas, and Texas citizens and thanked Pete Flores for his work on "this important issue". He later described the bill as part of the "bold, conservative agenda" that the Texas legislature passed during the 2025 legislative session. Phil King, one of the bill's co-sponsors, said that issue of child pornography had "infiltrated" the state's schools and said he was proud that the Texas legislature had "taken decisive action to protect our vulnerable Texans". Another co-sponsor of the legislation, Tan Parker described the law as "decisive action" to protect the children within Texas, and said he looked "forward to advancing this critical legislation" onward from the Texas Senate Criminal Justice Committee. He also described the legislation as "critical" action to protect the state's children from A.I.-generated child pornography and an "effective tool for law enforcement" to crack down on child porn perpetrators. Other supporters, such as police, and prosecutors, called the legislation an "important step" to ensure that images generated with A.I., along with deepfakes, "can't be shared with impunity" and necessary to ensure children's protection. Flores told senators that technology which enabled the production of "offensive" material by child predators had "no redeeming value whatsoever" and asserted that the materials had often been "used to groom and abuse children". John Leigh, a co-founder of Anime Matsuri, one of the largest conventions for anime within Texas, reassured those who contacted him, saying that the law is not targeted at anime and manga fans, stated that he supported the legislation, describing it as a step "in the right direction," and said that he did not believe it would "negatively impact" anime or related art in the state. Also, State Representative Dade Phelan emphasized the legislation's urgency to deal with A.I. and child pornography, adding that they need to "put some guardrails on it to where the public is being taken care of". The Texas Policy Research Foundation supported the legislation, saying that although it may lead to increased demands on state and local governmental resources, higher costs for local governments, and possible "civil liberty concerns" around online censorship, it represents a "necessary legal update" to address exploitation of children online, while "modernizing enforcement mechanisms" and recommended that lawmakers vote in favor of the law. Additionally, the group Texans for Fiscal Responsibility supported the law, arguing that it strengthened state law, upheld public safety, protected minors, and called it a "common-sense bill" protecting and promoting the "common good", children, and fell within the "proper role" of government. The Texas Public Policy Foundation also expressed their support for the law. A policy director for aforementioned conservative think tank, Zach Whiting, told the Texas Senate Committee on Criminal Justice, on March 4, 2025, that the foundation would assist legislators ans staff to "advance any and all measures to protect kids online" and shared an excerpt from of research paper about threats posed by A.I. in creating "sexually explicit deepfakes of children". === Opposition === Although the bill passed both chambers unanimously, there were some reports that the bill stalled due to opposition from Democratic lawmakers. Additionally, some individuals expressed concerns about the broad nature of the law's provisions. Anime Matsuri co-founder Deneice Leigh called for the law's wording to be clarified because "artists are anxious about displaying or selling fan art" even if the intention is "not be to penalize creators". She also described the bill as "vague and open to interpretation" as to what would be considered obscene and offensive while noting that the bill is not aiming to "target artists". Benjamin Napier, owner of Mansfield Comics and Manga in Mansfield, Texas, said that at first he felt the law was "ridiculous" and "kind of frivolous" at first, part of a "misguided puritanical onslaught", and noted that he would not cow "to the puritanical regime" if it was enacted. Kirsten Cather, an Asian Studies scholar at University of Texas, expressed concern at the law's misinterpretation because "many anime characters appear youthful, regardless of their actual age", said that the law could "stifle creative expression", and noted that the law's scope is broad enough to have manga and anime under scrutiny, a "real slippery slope here that's being breached". Marcel Green of Screen Rant said that the law's ambiguity led to concerns from manga and anime fans, and theorized that the law's application to a fan within Texas, who downloaded the 368th chapter of My Hero Academia, which has a "sexualized depiction" of an "underage high school student", would result in a criminal offense of "180 days to two years in state jail, along with a fine of up to $10,000". Green also said the law is problematic because many anime and manga characters are young, with many protagonists as minors and argued that the law could apply in limited cases, if state officials deemed an anime or manga under scrutiny as lacking "artistic value". Evan D. Mullicane, on the same site, said the vague wording of the legislation made it "dangerous" for anime such as Dragon Ball and Naruto, and could impact more than hentai, predicting it will be used against more than its "intended target" and be used to censor stories with "young LGBTQIA characters". Another critic on the same site, Carlyle Edmundson, called for anime fans to step up and prevent the law's enactment "for the good of artists and fans everywhere", saying that the legislation was "draconian" and claimed it was the most extreme case of anime and manga censorship in U.S. history. Nick Valdez of ComicBook.com said that the legislation could lead to censorship of "many anime and manga projects," like Kill la Kill and The 100 Girlfriends Who Really, Really, Really, Really, Really Love You, becoming a crime, and said that even if the law is enforced in a case-by-case basis, it could lead to a "much larger ban of materials in the state" itself due to the content of certain manga and anime. Vanessa Esguerra of The Mary Sue argued that possession of manga like Berserk and Vagabond, or viewing Dandadan, could be deemed illegal under the law, due to various parts of each of these media, and asserted that viewing and owning certain anime and other media, falling under the law's provisions,

Agent Communications Language

Agent Communication Language (ACL) consists of computer communication protocols that are intended for AI agents to communicate with each other. In 2007, protocols of this nature were proposed which include: FIPA-ACL (by the Foundation for Intelligent Physical Agents, a standardization consortium) KQML (Knowledge Query and Manipulation Language) After the surge in Generative AI with the use of Transformers and Large language models, the definition of agent has shifted away from physical agents to signify software systems built using the principles of Agentic AI. A new protocol to emerge in this area is Natural Language Interaction Protocol (NLIP). NLIP is an application-level communication protocol defined between AI Agents or between a human and an AI agent. Ecma International; a standards body which develops and publishes international standards for the information and communication industry; published on 10 December 2025 five new standards and one technical report defining the Natural Language Interaction Protocol (NLIP). As a result, we can define agent communication protocols into two categories: ontology based agent communication protocols and generative AI based agent communication protocols. Ontology based agent communication protocols use a common ontology to be used between agents. An ontology is a part of the agent's knowledge base that describes what kind of things an agent can deal with and how they are related to each other. FIPA-ACL and KQML are examples of such protocols. These protocols rely on speech act theory developed by Searle in the 1960s and enhanced by Winograd and Flores in the 1970s. They define a set of performatives, also called Communicative Acts, and their meaning (e.g. ask-one). The content of the performative is not standardized, but varies from system to system. Implementation support of FIPA-ACL is included in FIPA-OS and Jade. Generative AI based agent communication protocols such as NLIP do not require a shared ontology among communicating agents. In its stead, they use generative AI models to translate natural language text, images, videos or other modalities of data into a local ontology. This provides for hot-extensibility where the same protocol can be used for multiple communication needs, and simplifies version control since different agents can use different versions of a shared ontology. NLIP has been designed with security considerations in mind. The specification and standards comprising NLIP are developed and maintained by Ecma Technical Community 56.

Digital sculpting

Digital sculpting, also known as sculpt modeling or 3D sculpting, is the use of software that offers tools to push, pull, smooth, grab, pinch or otherwise manipulate a digital object as if it were made of a real-life substance such as clay. == Sculpting technology == The geometry used in digital sculpting programs to represent the model can vary; each offers different benefits and limitations. The majority of digital sculpting tools on the market use mesh-based geometry, in which an object is represented by an interconnected surface mesh of polygons that can be pushed and pulled around. This is somewhat similar to the physical process of beating copper plates to sculpt a scene in relief. Other digital sculpting tools use voxel-based geometry, in which the volume of the object is the basic element. Material can be added and removed, much like sculpting in clay. Still other tools make use of more than one basic geometry representation. A benefit of mesh-based programs is that they support sculpting at multiple resolutions on a single model. Areas of the model that are finely detailed can have very small polygons while other areas can have larger polygons. In many mesh-based programs, the mesh can be edited at different levels of detail, and the changes at one level will propagate to higher and lower levels of model detail. A limitation of mesh-based sculpting is the fixed topology of the mesh; the specific arrangement of the polygons can limit the ways in which detail can be added or manipulated. A benefit of voxel-based sculpting is that voxels allow complete freedom over form. The topology of a model can be altered continually during the sculpting process as material is added and subtracted, which frees the sculptor from considering the layout of polygons on the model's surface. After sculpting, it may be necessary to retopologize the model to obtain a clean mesh for use in animation or real-time rendering. Voxels, however, are more limited in handling multiple levels of detail. Unlike mesh-based modeling, broad changes made to voxels at a low level of detail may completely destroy finer details. == Uses == Sculpting can often introduce details to meshes that would otherwise have been difficult or impossible to create using traditional 3D modeling techniques. This makes it preferable for achieving photorealistic and hyperrealistic results, though, many stylized results are achieved as well. Sculpting is primarily used in high poly organic modeling (the creation of 3D models which consist mainly of curves or irregular surfaces, as opposed to hard surface modeling). It is also used by auto manufacturers in their design of new cars. It can create the source meshes for low poly game models used in video games. In conjunction with other 3D modeling and texturing techniques and Displacement and Normal mapping, it can greatly enhance the appearance of game meshes often to the point of photorealism. Some sculpting programs like 3D-Coat, Zbrush, and Mudbox offer ways to integrate their workflows with traditional 3D modeling and rendering programs. Conversely, 3D modeling applications like 3ds Max, Maya and MODO are now incorporating sculpting capability as well, though these are usually less advanced than tools found in sculpting-specific applications. High poly sculpts are also extensively used in CG artwork for movies, industrial design, art, photorealistic illustrations, and for prototyping in 3D printing. == 3D print == Sculptors and digital artists use digital sculpting to create a model (or Digital Twin) to be materialized through CNC technologies including 3D printing. The final sculptures are often called Digital Sculpture or 3D printed art. While digital technologies have emerged in many art disciplines (painting, photography), this is less the case for digital sculpture due to the higher complexity and technology limitations to produce the final sculpture. == Sculpting Process == The best way to learn sculpture is by understanding primary, secondary and tertiary forms. First, break down the object you want to make down its basic shapes, such as a sphere or cube. Focus on making the large, overall shape of the object. After that, work on the bigger shapes on top of or inside the object. These can be protrusions or cut outs. Then, do a final detail pass, such as pores or lines to break up the shape. == Sculpting programs == There are a number of digital sculpting tools available. Some popular tools for creating are: Traditional 3D modeling suites are also beginning to include sculpting capability. 3D modeling programs which currently feature some form of sculpting include the following:

ITools Resourceome

iTools is a distributed infrastructure for managing, discovery, comparison and integration of computational biology resources. iTools employs Biositemap technology to retrieve and service meta-data about diverse bioinformatics data services, tools, and web-services. iTools is developed by the National Centers for Biomedical Computing as part of the NIH Road Map Initiative.