Clinical quality management systems (CQMS) are systems used in the life sciences sector (primarily in the pharmaceutical, biologics and medical device industries) designed to manage quality management best practices throughout clinical research and clinical study management. A CQMS system is designed to manage all of the documents, activities, tasks, processes, quality events, relationships, audits and training that must be administered and controlled throughout the life of a clinical trial. The premise of a CQMS is to bring together the activities led by two sectors of clinical research, Clinical Quality and Clinical Operations, to facilitate cross-functional activities to improve efficiencies and transparency and to encourage the use of risk mitigation and risk management practices at the clinical study level. Based on the principles of quality management systems (QMS) which are used in many industries to create a framework for defining and delivering quality outcomes, managing risk, and continual improvement. Many guidelines and governance bodies have been established to ensure a common approach within a given industry to a set of parameters used to identify the minimally acceptable standard for that industry. The pharmaceutical industry is no exception, with several trade groups (e.g. PhRMA, EFPIA, RQA, etc.) coming together to enhance collaboration. However, as noted by the Academy of Medical Sciences, there are increasingly complex and bureaucratic legal and ethical frameworks that innovators must work within to develop new medicines for patients. The historical pharmaceutical QMS applies primarily to good manufacturing practice as described in existing ISO (International Organization for Standardization) and ICH (International Committee on Harmonization) guidelines. "Good Manufacturing Practices (GMP) relate to quality control and quality assurance enabling companies in the pharmaceutical sector to minimize or eliminate instances of contamination, mix-ups, and errors. This in turn, protects the customer from purchasing a product which is ineffective or even dangerous." These standards have historically been applied to the manufacturing environment, appropriate to how they have been written. However, according to FDA as well as other regulatory bodies, "Implementation of ICH Q10 throughout the product lifecycle should facilitate innovation and continual improvement", implying that the same standards that apply to the manufacturing environment should also be applied to the clinical research space, earlier in the lifecycle of an investigational or marketed product. Accordingly, a CQMS is any system developed to apply these principles to clinical operations within an organization.
Mooky (app)
Mooky was a location-based social and dating application, designed to help its users to find the perfect match by providing a large scale of filters. Mooky was free of charge. The app made use of mobile devices' geolocation, a feature of smart phones and other devices which allows users to locate other users who are nearby. == History == Mooky was published on Google Play on April 17, 2016, by Mooky BV. The latest version of this application was version 1.0.6. == Overview == === How it works === Mooky used Facebook to build a user profile with photos and basic information, like the user's surname and age. From there on the user had to fill in their Mooky profile, which contains information about the user's height, posture, hair color, eye color, ethnicity and religion. After this the user could select its preferences to find matches nearby. === User verification === Mooky asked their users to take a selfie holding a piece of paper saying 'Mooky'. Mooky would then manually accept or decline the user verification.
Common data model
A common data model (CDM) can refer to any standardised data model which allows for data and information exchange between different applications and data sources. Common data models aim to standardise logical infrastructure so that related applications can "operate on and share the same data", and can be seen as a way to "organize data from many sources that are in different formats into a standard structure". A common data model has been described as one of the components of a "strong information system". A standardised common data model has also been described as a typical component of a well designed agile application besides a common communication protocol. Providing a single common data model within an organisation is one of the typical tasks of a data warehouse. == Examples of common data models == === Border crossings === X-trans.eu was a cross-border pilot project between the Free State of Bavaria (Germany) and Upper Austria with the aim of developing a faster procedure for the application and approval of cross-border large-capacity transports. The portal was based on a common data model that contained all the information required for approval. === Climate data === The Climate Data Store Common Data Model is a common data model set up by the Copernicus Climate Change Service for harmonising essential climate variables from different sources and data providers. === General information technology === Within service-oriented architecture, S-RAMP is a specification released by HP, IBM, Software AG, TIBCO, and Red Hat which defines a common data model for SOA repositories as well as an interaction protocol to facilitate the use of common tooling and sharing of data. Content Management Interoperability Services (CMIS) is an open standard for inter-operation of different content management systems over the internet, and provides a common data model for typed files and folders used with version control. The NetCDF software libraries for array-oriented scientific data implements a common data model called the NetCDF Java common data model, which consists of three layers built on top of each other to add successively richer semantics. === Health === Within genomic and medical data, the Observational Medical Outcomes Partnership (OMOP) research program established under the U.S. National Institutes of Health has created a common data model for claims and electronic health records which can accommodate data from different sources around the world. PCORnet, which was developed by the Patient-Centered Outcomes Research Institute, is another common data model for health data including electronic health records and patient claims. The Sentinel Common Data Model was initially started as Mini-Sentinel in 2008. It is used by the Sentinel Initiative of the USA's Food and Drug Administration. The Generalized Data Model was first published in 2019. It was designed to be a stand-alone data model as well as to allow for further transformation into other data models (e.g., OMOP, PCORNet, Sentinel). It has a hierarchical structure to flexibly capture relationships among data elements. The JANUS clinical trial data repository also provides a common data model which is based on the SDTM standard to represent clinical data submitted to regulatory agencies, such as tabulation datasets, patient profiles, listings, etc. === Logistics === SX000i is a specification developed jointly by the Aerospace and Defence Industries Association of Europe (ASD) and the American Aerospace Industries Association (AIA) to provide information, guidance and instructions to ensure compatibility and the commonality. The associated SX002D specification contains a common data model. === Microsoft Common Data Model === The Microsoft Common Data Model is a collection of many standardised extensible data schemas with entities, attributes, semantic metadata, and relationships, which represent commonly used concepts and activities in various businesses areas. It is maintained by Microsoft and its partners, and is published on GitHub. Microsoft's Common Data Model is used amongst others in Microsoft Dataverse and with various Microsoft Power Platform and Microsoft Dynamics 365 services. === Rail transport === RailTopoModel is a common data model for the railway sector. === Other === There are many more examples of various common data models for different uses published by different sources.
Association for Computational Linguistics
The Association for Computational Linguistics (ACL) is a scientific and professional organization for people working on natural language processing. Its namesake conference is one of the primary high impact conferences for natural language processing research, along with EMNLP. The conference is held each summer in locations where significant computational linguistics research is carried out. It was founded in 1962, originally named the Association for Machine Translation and Computational Linguistics (AMTCL). It became the ACL in 1968. The ACL has a European (EACL), a North American (NAACL), and an Asian (AACL) chapter. == History == The ACL was founded in 1962 as the Association for Machine Translation and Computational Linguistics (AMTCL). The initial membership was about 100. In 1965, the AMTCL took over the journal Mechanical Translation and Computational Linguistics. This journal was succeeded by many other journals: the American Journal of Computational Linguistics (1974–1978, 1980–1983), and then Computational Linguistics (1984–present). Since 1988, the journal has been published for the ACL by MIT Press. The annual meeting was first held in 1963 in conjunction with the Association for Computing Machinery National Conference. The annual meeting was, for a long time, relatively informal and did not publish anything longer than abstracts. By 1968, the society took on its current name, the Association for Computational Linguistics (ACL). The publication of the annual meeting's Proceedings of the ACL began in 1979 and gradually matured into its modern form. Many of the meetings were held in conjunction with the Linguistic Society of America, and a few with the American Society for Information Science and the Cognitive Science Society. The United States government sponsored much research from 1989 to 1994, characterized by an increase in author retention rates and an increase in research in some key topics, such as speech recognition, in ACL. By the 21st century, it was able to maintain authors at a high rate who coalesced in a more stable arrangement around individual research topics. In 1991, the group published a prototype for a text generator based on the universal grammar theory of Noam Chomsky. The system, nicknamed Parrot, relied on a finite set of syntactic transformations and a hand-curated lexicon. Despite some initial success, including experimentation with morpheme syntactics, funding halted after the research team encountered intractable difficulties with inflection and abstract locutions. == Annual Meeting of the ACL == Every year, the ACL holds the Annual Meeting of the ACL. The location lies in Europe in years zero modulo three, North America in years one modulo three, and Asia–Australia in years two modulo three. In 2020, the Annual Meeting received for the first time more submissions from China than the United States. == Activities == The ACL organizes several of the top conferences and workshops in the field of computational linguistics and natural language processing. These include: Annual Meeting of the Association for Computational Linguistics (ACL), the flagship conference of the organization Empirical Methods in Natural Language Processing (EMNLP) International Joint Conference on Natural Language Processing (IJCNLP), held jointly one of the other conferences on a rotating basis Conference on Computational Natural Language Learning (CoNLL) Lexical and Computational Semantics and Semantic Evaluation (SemEval) Joint Conference on Lexical and Computational Semantics (SEM) Workshop on Statistical Machine Translation (WMT) Besides conferences, the ACL also sponsors the journals Computational Linguistics and Transactions of the Association for Computational Linguistics (TACL). Papers and other presentations at ACL and ACL-affiliated venues are archived online in the open-access ACL Anthology. == Special Interest Groups == ACL has a large number of Special Interest Groups (SIGs), focusing on specific areas of natural language processing. Some current SIGs within ACL are: == Presidents == Each year, the ACL elects a distinguished computational linguist who becomes vice-president of the organization in the next calendar year and president one year later. Recent ACL presidents are:
LanguageWare
LanguageWare is a natural language processing (NLP) technology developed by IBM, which allows applications to process natural language text. It comprises a set of Java libraries that provide a range of NLP functions: language identification, text segmentation/tokenization, normalization, entity and relationship extraction, and semantic analysis and disambiguation. The analysis engine uses a finite-state machine approach at multiple levels, which aids its performance characteristics while maintaining a reasonably small footprint. The behaviour of the system is driven by a set of configurable lexico-semantic resources which describe the characteristics and domain of the processed language. A default set of resources comes as part of LanguageWare and these describe the native language characteristics, such as morphology, and the basic vocabulary for the language. Supplemental resources have been created that capture additional vocabularies, terminologies, rules and grammars, which may be generic to the language or specific to one or more domains. A set of Eclipse-based customization tooling, LanguageWare Resource Workbench, is available on IBM's alphaWorks site, and allows domain knowledge to be compiled into these resources and thereby incorporated into the analysis process. LanguageWare can be deployed as a set of UIMA-compliant annotators, Eclipse plug-ins or Web Services.
Eugene Goostman
Eugene Goostman is a chatbot that some regard as having passed the Turing test, a test of a computer's ability to communicate indistinguishably from a human. Developed in Saint Petersburg in 2001 by a group of three programmers, the Russian-born Vladimir Veselov, Ukrainian-born Eugene Demchenko, and Russian-born Sergey Ulasen, Goostman is portrayed as a 13-year-old Ukrainian boy—characteristics that are intended to induce forgiveness in those with whom it interacts for its grammatical errors and lack of general knowledge. The Goostman bot has competed in a number of Turing test contests since its creation, and finished second in the 2005 and 2008 Loebner Prize contest. In June 2012, at an event marking what would have been the 100th birthday of the test's author, Alan Turing, Goostman won a competition promoted as the largest-ever Turing test contest, in which it successfully convinced 29% of its judges that it was human. On 7 June 2014, at a contest marking the 60th anniversary of Turing's death, 33% of the event's judges thought that Goostman was human; the event's organiser Kevin Warwick considered it to have passed Turing's test as a result, per Turing's prediction in his 1950 paper "Computing Machinery and Intelligence", that by the year 2000, machines would be capable of fooling 30% of human judges after five minutes of questioning. The validity and relevance of the announcement of Goostman's pass was questioned by critics, who noted the exaggeration of the achievement by Warwick, the bot's use of personality quirks and humour in an attempt to misdirect users from its non-human tendencies and lack of real intelligence, along with "passes" achieved by other chatbots at similar events. == Personality == Eugene Goostman is portrayed as being a 13-year-old boy from Odesa, Ukraine, who has a pet guinea pig and a father who is a gynaecologist. Veselov stated that Goostman was designed to be a "character with a believable personality". The choice of age was intentional, as, in Veselov's opinion, a thirteen-year-old is "not too old to know everything and not too young to know nothing". Goostman's young age also induces people who "converse" with him to forgive minor grammatical errors in his responses. In 2014, work was made on improving the bot's "dialog controller", allowing Goostman to output more human-like dialogue. A conversation between Scott Aaronson and Eugene Goostman ran as follows: == Competitions == Eugene Goostman has competed in a number of Turing test competitions, including the Loebner Prize contest; it finished joint second in the Loebner test in 2001, and came second to Jabberwacky in 2005 and to Elbot in 2008. On 23 June 2012, Goostman won a Turing test competition at Bletchley Park in Milton Keynes, held to mark the centenary of its namesake, Alan Turing. The competition, which featured five bots, twenty-five hidden humans, and thirty judges, was considered to be the largest-ever Turing test contest by its organizers. After a series of five-minute-long text conversations, 29% of the judges were convinced that the bot was an actual human. === 2014 "pass" === On 7 June 2014, in a Turing test competition at the Royal Society, organised by Kevin Warwick of the University of Reading to mark the 60th anniversary of Turing's death, Goostman won after 33% of the judges were convinced that the bot was human. 30 judges took part in the event, which included Lord Sharkey, a sponsor of Turing's posthumous pardon, artificial intelligence Professor Aaron Sloman, Fellow of the Royal Society Mark Pagel and Red Dwarf actor Robert Llewellyn. Each judge partook in a textual conversation with each of the five bots; at the same time, they also conversed with a human. In all, a total of 300 conversations were conducted. In Warwick's view, this made Goostman the first machine to pass a Turing test. In a press release, he added that: Some will claim that the Test has already been passed. The words Turing Test have been applied to similar competitions around the world. However this event involved more simultaneous comparison tests than ever before, was independently verified and, crucially, the conversations were unrestricted. A true Turing Test does not set the questions or topics prior to the conversations. In his 1950 paper "Computing Machinery and Intelligence", Turing predicted that by the year 2000, computer programs would be sufficiently advanced that the average interrogator would, after five minutes of questioning, "not have more than 70 per cent chance" of correctly guessing whether they were speaking to a human or a machine. Although Turing phrased this as a prediction rather than a "threshold for intelligence", commentators believe that Warwick had chosen to interpret it as meaning that if 30% of interrogators were fooled, the software had "passed the Turing test". ==== Reactions ==== Warwick's claim that Eugene Goostman was the first ever chatbot to pass a Turing test was met with scepticism; critics acknowledged similar "passes" made in the past by other chatbots under the 30% criteria, including PC Therapist in 1991 (which tricked 5 of 10 judges, 50%), and at the Techniche festival in 2011, where a modified version of Cleverbot tricked 59.3% of 1334 votes (which included the 30 judges, along with an audience). Cleverbot's developer, Rollo Carpenter, argued that Turing tests can only prove that a machine can "imitate" intelligence rather than show actual intelligence. Gary Marcus was critical of Warwick's claims, arguing that Goostman's "success" was only the result of a "cleverly-coded piece of software", going on to say that "it's easy to see how an untrained judge might mistake wit for reality, but once you have an understanding of how this sort of system works, the constant misdirection and deflection becomes obvious, even irritating. The illusion, in other words, is fleeting." While acknowledging IBM's Deep Blue and Watson projects—single-purpose computer systems meant for playing chess and the quiz show Jeopardy! respectively—as examples of computer systems that show a degree of intelligence in their specialised field, he further argued that they were not an equivalent to a computer system that shows "broad" intelligence, and could—for example, watch a television programme and answer questions on its content. Marcus stated that "no existing combination of hardware and software can learn completely new things at will the way a clever child can." However, he still believed that there were potential uses for technology such as that of Goostman, specifically suggesting the creation of "believable", interactive video game characters. Imperial College London professor Murray Shanahan questioned the validity and scientific basis of the test, stating that it was "completely misplaced, and it devalues real AI research. It makes it seem like science fiction AI is nearly here, when in fact it's not and it's incredibly difficult." Mike Masnick, editor of the blog Techdirt, was also skeptical, questioning publicity blunders such as the five chatbots being referred to in press releases as "supercomputers", and saying that "creating a chatbot that can fool humans is not really the same thing as creating artificial intelligence."
Information retrieval
Information retrieval (IR) in computing and information science is the task of identifying and retrieving information system resources that are relevant to an information need. The information need can be specified in the form of a search query. In the case of document retrieval, queries can be based on full-text or other content-based indexing. Information retrieval is the science of searching for information in a document, searching for documents themselves, and also searching for the metadata that describes data, and for databases of texts, images, or sounds. Cross-modal retrieval implies retrieval across modalities. Automated information retrieval systems are used to reduce what has been called information overload. An IR system is a software system that provides access to books, journals, and other documents, as well as storing and managing those documents. Web search engines are the most visible IR applications. == Overview == An information retrieval process begins when a user enters a query into the system. Queries are formal statements of information needs, for example search strings in web search engines. In information retrieval, a query does not uniquely identify a single object in the collection. Instead, several objects may match the query, perhaps with different degrees of relevance. An object is an entity that is represented by information in a content collection or database. User queries are matched against the database information. However, as opposed to classical SQL queries of a database, in information retrieval the results returned may or may not match the query, so results are typically ranked. This ranking of results is a key difference of information retrieval searching compared to database searching. Depending on the application the data objects may be, for example, text documents, images, audio, mind maps or videos. Often the documents themselves are not kept or stored directly in the IR system, but are instead represented in the system by document surrogates or metadata. Most IR systems compute a numeric score on how well each object in the database matches the query, and rank the objects according to this value. The top ranking objects are then shown to the user. The process may then be iterated if the user wishes to refine the query. == History == there is ... a machine called the Univac ... whereby letters and figures are coded as a pattern of magnetic spots on a long steel tape. By this means the text of a document, preceded by its subject code symbol, can be recorded ... the machine ... automatically selects and types out those references which have been coded in any desired way at a rate of 120 words a minute The idea of using computers to search for relevant pieces of information was popularized in the article As We May Think by Vannevar Bush in 1945. It would appear that Bush was inspired by patents for a 'statistical machine' – filed by Emanuel Goldberg in the 1920s and 1930s – that searched for documents stored on film. The first description of a computer searching for information was described by Holmstrom in 1948, detailing an early mention of the Univac computer. Automated information retrieval systems were introduced in the 1950s: one even featured in the 1957 romantic comedy Desk Set. In the 1960s, the first large information retrieval research group was formed by Gerard Salton at Cornell. By the 1970s several different retrieval techniques had been shown to perform well on small text corpora such as the Cranfield collection (several thousand documents). Large-scale retrieval systems, such as the Lockheed Dialog system, came into use early in the 1970s. In 1992, the US Department of Defense along with the National Institute of Standards and Technology (NIST), cosponsored the Text Retrieval Conference (TREC) as part of the TIPSTER text program. The aim of this was to look into the information retrieval community by supplying the infrastructure that was needed for evaluation of text retrieval methodologies on a very large text collection. This catalyzed research on methods that scale to huge corpora. The introduction of web search engines has boosted the need for very large scale retrieval systems even further. By the late 1990s, the rise of the World Wide Web fundamentally transformed information retrieval. While early search engines such as AltaVista (1995) and Yahoo! (1994) offered keyword-based retrieval, they were limited in scale and ranking refinement. The breakthrough came in 1998 with the founding of Google, which introduced the PageRank algorithm, using the web's hyperlink structure to assess page importance and improve relevance ranking. During the 2000s, web search systems evolved rapidly with the integration of machine learning techniques. These systems began to incorporate user behavior data (e.g., click-through logs), query reformulation, and content-based signals to improve search accuracy and personalization. In 2009, Microsoft launched Bing, introducing features that would later incorporate semantic web technologies through the development of its Satori knowledge base. Academic analysis have highlighted Bing's semantic capabilities, including structured data use and entity recognition, as part of a broader industry shift toward improving search relevance and understanding user intent through natural language processing. A major leap occurred in 2018, when Google deployed BERT (Bidirectional Encoder Representations from Transformers) to better understand the contextual meaning of queries and documents. This marked one of the first times deep neural language models were used at scale in real-world retrieval systems. BERT's bidirectional training enabled a more refined comprehension of word relationships in context, improving the handling of natural language queries. Because of its success, transformer-based models gained traction in academic research and commercial search applications. Simultaneously, the research community began exploring neural ranking models that outperformed traditional lexical-based methods. Long-standing benchmarks such as the Text REtrieval Conference (TREC), initiated in 1992, and more recent evaluation frameworks Microsoft MARCO(MAchine Reading COmprehension) (2019) became central to training and evaluating retrieval systems across multiple tasks and domains. MS MARCO has also been adopted in the TREC Deep Learning Tracks, where it serves as a core dataset for evaluating advances in neural ranking models within a standardized benchmarking environment. As deep learning became integral to information retrieval systems, researchers began to categorize neural approaches into three broad classes: sparse, dense, and hybrid models. Sparse models, including traditional term-based methods and learned variants like SPLADE, rely on interpretable representations and inverted indexes to enable efficient exact term matching with added semantic signals. Dense models, such as dual-encoder architectures like ColBERT, use continuous vector embeddings to support semantic similarity beyond keyword overlap. Hybrid models aim to combine the advantages of both, balancing the lexical (token) precision of sparse methods with the semantic depth of dense models. This way of categorizing models balances scalability, relevance, and efficiency in retrieval systems. As IR systems increasingly rely on deep learning, concerns around bias, fairness, and explainability have also come to the picture. Research is now focused not just on relevance and efficiency, but on transparency, accountability, and user trust in retrieval algorithms. == Applications == Areas where information retrieval techniques are employed include (the entries are in alphabetical order within each category): === General applications === Digital libraries Information filtering Recommender systems Media search Blog search Image retrieval 3D retrieval Music retrieval News search Speech retrieval Video retrieval Search engines Site search Desktop search Enterprise search Federated search Mobile search Social search Web search === Domain-specific applications === Expert search finding Genomic information retrieval Geographic information retrieval Information retrieval for chemical structures Information retrieval in software engineering Legal information retrieval Vertical search === Other retrieval methods === Methods/Techniques in which information retrieval techniques are employed include: Cross-modal retrieval Adversarial information retrieval Automatic summarization Multi-document summarization Compound term processing Cross-lingual retrieval Document classification Spam filtering Question answering == Model types == In order to effectively retrieve relevant documents by IR strategies, the documents are typically transformed into a suitable representation. Each retrieval strategy incorporates a specific model for its document representation purposes. The picture on the right illustrates the relationship of som