A biohybrid microswimmer also known as biohybrid nanorobot, can be defined as a microswimmer that consist of both biological and artificial constituents, for instance, one or several living microorganisms attached to one or various synthetic parts. In recent years nanoscopic and mesoscopic objects have been designed to collectively move through direct inspiration from nature or by harnessing its existing tools. Small mesoscopic to nanoscopic systems typically operate at low Reynolds numbers (Re ≪ 1), and understanding their motion becomes challenging. For locomotion to occur, the symmetry of the system must be broken. In addition, collective motion requires a coupling mechanism between the entities that make up the collective. To develop mesoscopic to nanoscopic entities capable of swarming behaviour, it has been hypothesised that the entities are characterised by broken symmetry with a well-defined morphology, and are powered with some material capable of harvesting energy. If the harvested energy results in a field surrounding the object, then this field can couple with the field of a neighbouring object and bring some coordination to the collective behaviour. Such robotic swarms have been categorised by an online expert panel as among the 10 great unresolved group challenges in the area of robotics. Although investigation of their underlying mechanism of action is still in its infancy, various systems have been developed that are capable of undergoing controlled and uncontrolled swarming motion by harvesting energy (e.g., light, thermal, etc.). Over the past decade, biohybrid microrobots, in which living mobile microorganisms are physically integrated with untethered artificial structures, have gained growing interest to enable the active locomotion and cargo delivery to a target destination. In addition to the motility, the intrinsic capabilities of sensing and eliciting an appropriate response to artificial and environmental changes make cell-based biohybrid microrobots appealing for transportation of cargo to the inaccessible cavities of the human body for local active delivery of diagnostic and therapeutic agents. == Background == Biohybrid microswimmers can be defined as microswimmers that consist of both biological and artificial constituents, for instance, one or several living microorganisms attached to one or various synthetic parts. The pioneers of this field, ahead of their time, were Montemagno and Bachand with a 1999 work regarding specific attachment strategies of biological molecules to nanofabricated substrates enabling the preparation of hybrid inorganic/organic nanoelectromechanical systems, so called NEMS. They described the production of large amounts of F1-ATPase from the thermophilic bacteria Bacillus PS3 for the preparation of F1-ATPase biomolecular motors immobilized on a nanoarray pattern of gold, copper or nickel produced by electron beam lithography. These proteins were attached to one micron microspheres tagged with a synthetic peptide. Consequently, they accomplished the preparation of a platform with chemically active sites and the development of biohybrid devices capable of converting energy of biomolecular motors into useful work. One of the most fundamental questions in science is what defines life. Collective motion is one of the hallmarks of life. This is commonly observed in nature at various dimensional levels as energized entities gather, in a concerted effort, into motile aggregated patterns. These motile aggregated events can be noticed, among many others, as dynamic swarms; e.g., unicellular organisms such as bacteria, locust swarms, or the flocking behaviour of birds. Ever since Newton established his equations of motion, the mystery of motion on the microscale has emerged frequently in scientific history, as famously demonstrated by a couple of articles that should be discussed briefly. First, an essential concept, popularized by Osborne Reynolds, is that the relative importance of inertia and viscosity for the motion of a fluid depends on certain details of the system under consideration. The Reynolds number Re, named in his honor, quantifies this comparison as a dimensionless ratio of characteristic inertial and viscous forces: R e = ρ u l μ {\displaystyle \mathrm {Re} ={\frac {\rho ul}{\mu }}} Here, ρ represents the density of the fluid; u is a characteristic velocity of the system (for instance, the velocity of a swimming particle); l is a characteristic length scale (e.g., the swimmer size); and μ is the viscosity of the fluid. Taking the suspending fluid to be water, and using experimentally observed values for u, one can determine that inertia is important for macroscopic swimmers like fish (Re = 100), while viscosity dominates the motion of microscale swimmers like bacteria (Re = 10−4). The overwhelming importance of viscosity for swimming at the micrometer scale has profound implications for swimming strategy. This has been discussed memorably by E. M. Purcell, who invited the reader into the world of microorganisms and theoretically studied the conditions of their motion. In the first place, propulsion strategies of large scale swimmers often involve imparting momentum to the surrounding fluid in periodic discrete events, such as vortex shedding, and coasting between these events through inertia. This cannot be effective for microscale swimmers like bacteria: due to the large viscous damping, the inertial coasting time of a micron-sized object is on the order of 1 μs. The coasting distance of a microorganism moving at a typical speed is about 0.1 angstroms (Å). Purcell concluded that only forces that are exerted in the present moment on a microscale body contribute to its propulsion, so a constant energy conversion method is essential. Microorganisms have optimized their metabolism for continuous energy production, while purely artificial microswimmers (microrobots) must obtain energy from the environment, since their on-board-storage-capacity is very limited. As a further consequence of the continuous dissipation of energy, biological and artificial microswimmers do not obey the laws of equilibrium statistical physics, and need to be described by non-equilibrium dynamics. Mathematically, Purcell explored the implications of low Reynolds number by taking the Navier-Stokes equation and eliminating the inertial terms: μ ∇ 2 u − ∇ p = 0 {\displaystyle {\begin{aligned}\mu \nabla ^{2}\mathbf {u} -{\boldsymbol {\nabla }}p&={\boldsymbol {0}}\\\end{aligned}}} where u {\displaystyle \mathbf {u} } is the velocity of the fluid and ∇ p {\displaystyle {\boldsymbol {\nabla }}p} is the gradient of the pressure. As Purcell noted, the resulting equation — the Stokes equation — contains no explicit time dependence. This has some important consequences for how a suspended body (e.g., a bacterium) can swim through periodic mechanical motions or deformations (e.g., of a flagellum). First, the rate of motion is practically irrelevant for the motion of the microswimmer and of the surrounding fluid: changing the rate of motion will change the scale of the velocities of the fluid and of the microswimmer, but it will not change the pattern of fluid flow. Secondly, reversing the direction of mechanical motion will simply reverse all velocities in the system. These properties of the Stokes equation severely restrict the range of feasible swimming strategies. Recent publications of biohybrid microswimmers include the use of sperm cells, contractive muscle cells, and bacteria as biological components, as they can efficiently convert chemical energy into movement, and additionally are capable of performing complicated motion depending on environmental conditions. In this sense, biohybrid microswimmer systems can be described as the combination of different functional components: cargo and carrier. The cargo is an element of interest to be moved (and possibly released) in a customized way. The carrier is the component responsible for the movement of the biohybrid, transporting the desired cargo, which is linked to its surface. The great majority of these systems rely on biological motile propulsion for the transportation of synthetic cargo for targeted drug delivery/ There are also examples of the opposite case: artificial microswimmers with biological cargo systems. Over the past decade, biohybrid microrobots, in which living mobile microorganisms are physically integrated with untethered artificial structures, have gained growing interest to enable the active locomotion and cargo delivery to a target destination. In addition to the motility, the intrinsic capabilities of sensing and eliciting an appropriate response to artificial and environmental changes make cell-based biohybrid microrobots appealing for transportation of cargo to the inaccessible cavities of the human body for local active delivery of diagnostic and therapeutic agents. Active locomotion, targeting and steering of concentrated therape
PressWise
PressWise was digital imposition software to quickly and easily impose most any variety of flat and folding layouts. It was acquired by the Aldus Prepress Group affectionately known in the print and publishing industry as the Aldus WiseGuys in August 1991 from Emulation Technologies Inc. of Cleveland, Ohio. It was further developed by the Aldus Press Group and launched as the first of many Aldus prepress products in 1993. It was subsequently owned by Adobe Systems, then Luminous Corporation (Seattle), then Imation, and finally ScenicSoft. PressWise was discontinued by ScenicSoft in 1999 ultimately. == History == In February 2009, the PressWise copyright was acquired by Aethos Technologies and a new print automation product was launched by its creator, Eric Wold of Santa Rosa, California. This new product has no relationship to the old imposition software of the same name. It's notable that Larry Letteney, former President of Creo Americas was a board member and shareholder of Aethos Technologies during its early phase. Datatech SmartSoft acquired exclusive distribution rights to the software in September 2009. In September 2010 Datatech SmartSoft completed the acquisition of the PressWise brand and product.
Digital transaction management
Digital transaction management (DTM) is a category of cloud services designed to digitally manage document-based transactions. DTM removes the friction inherent in transactions that involve people, documents, and data to create faster, easier, more convenient, and secure processes. DTM goes beyond content and document management to include e-signatures, authentication and non-repudiation; enabling co-browsing between the customer and the business; document transfer and certification; secure archiving that goes beyond records management; and a variety of meta-processes around managing electronic transactions and the documents associated with them. DTM standards are proposed and managed by the xDTM Standard Association Aragon Research has estimated that "by YE 2016, 70% of large enterprises will have a DTM initiative underway or fully implemented."
WorkingPoint
WorkingPoint is a web-based application that provides a suite of small business management tools. It is designed to serve as a single point of access for various business operations, featuring a user-friendly interface. WorkingPoint's functionalities include double-entry bookkeeping, contact management, inventory management, invoicing, and bill and expense management. == Company == WorkingPoint, formerly Netbooks Inc, is a privately held corporation based in San Francisco, CA. The company is backed by CMEA Capital, also based in San Francisco. WorkingPoint has about ten employees and is led by CEO Tate Holt and Chairman Tom Proulx. Proulx is a co-founder of Intuit and an original author of that company’s Quicken personal finance software. The company was founded in 2007 under its original name Netbooks by co-creator Ridgely Evers. Evers set out to design a product that was more user-friendly than Intuit’s Quickbooks, which he also co-created. In mid-2009 the company officially rebranded itself and its flagship product “WorkingPoint”. The purpose of the re-branding was to disassociate the company from the product category of small laptops also known as netbooks. == Social Media Presence == WorkingPoint maintains a daily blog geared toward small business owners and managers. Each week the blog is updated with 3 WorkingPoint product feature or “how-to” posts, 2 subscriber company profiles, and 2 small business coaching posts. The company also maintains a Twitter page and a Facebook page. == Product Description (Free Version) == WorkingPoint allows businesses to invoice up to five customers (repeatedly) and provides account access for up to two individual users free of charge. Online Invoicing WorkingPoint allows users to create customized quotes and invoices online. The invoices can be used to bill customers via email or hardcopy post. WorkingPoint compiles the info from these invoices so users can track customer payments, inventory costs, shipping charges, accounts receivable and sales taxes. Users can also manage customer overpayments, provide customer loyalty discounts, and view a customer invoice history. Bill & Expense Management Users can track their bills and expenses by entering info into the WorkingPoint interface. WorkingPoint compiles this info so users can track categorized expenses, accounts paid, accounts payable, and vendor purchase history. The interface also allows users to add to their inventory while entering billing info. Double-Entry Bookeeping WorkingPoint automatically records entries under the double-entry bookkeeping system (also known as debits and credits) when the user completes invoicing and expense forms. Users can view transactions in general ledger format and perform closing entries if necessary. This functionality is designed for users who do not have an accounting background. Business Contact Management WorkingPoint provides an interface for users to manage their customer and vendor contact info. The software automatically tracks the user’s relationship with contacts, so users can track a contact’s sales and purchase history. Contacts can be imported and exported via numerous email clients including Microsoft Outlook, Yahoo! Mail, Google Gmail, and Mac Address Book. Inventory Management The software automatically adjusts inventory quantities after every purchase and sale. Users can track their current inventory quantity, average cost of inventory on-hand, cost of goods sold (COGS) and top-selling products. Users can also make manual adjustments to inventory when necessary. Financial Reporting Users can view a balance sheet, income statement, or cash flow statement pertaining to their business. The software automatically manages accruals to produce the balance sheet and income statement. Users can choose a data range from which to draw any of these reports. Financial reports can be converted to pdf format or exported (with formulas intact) to OpenOffice or Microsoft Excel. Cash Management WorkingPoint enables users to monitor cash balances on their bank accounts. The software automatically tracks cash inflows and outflows when users manage their accounts payable and accounts receivable. Business Dashboard The Business Dashboard visually and graphically displays key real-time business data. Users can customize the Dashboard to display data of their choosing. Online Company Profile Users can create an online company profile in order to have a presence on the Internet and as a basis for participation in WorkingPoint’s small business community features. Public profiles are featured in the WorkingPoint Company Directory and can be viewed externally using the URL format: https://businessname.workingpoint.com. == Product Description (Premium Version) == The premium version of WorkingPoint costs $10 per month. It includes all of the functionalities of the free version, allowing unlimited invoicing and account access. It also offers the following functions: 1099 Tax Reporting, invoice payment collection via PayPal, Email Marketing via VerticalResponse, and the Premium Reports & Accounting Package. 1099 Tax Reporting Users can identify qualifying companies and individuals for IRS Form 1099 or IRS Form 1096 reporting. WorkingPoint automatically tracks payments made to these companies and individuals. Users can then generate 1099 reports for distribution. Premium Reports & Accounting Package This includes: a Daily Operating Report providing users with sales and cash flow information, customizable accounts categorization, and cash flow statements using the indirect method of reporting. Invoice Payment Collection via PayPal Users can collect payment on their invoices via PayPal. Email Marketing via VerticalResponse The WorkingPoint premium package includes 500 email credits with the email marketing firm VerticalResponse.
Apache ORC
Apache ORC (Optimized Row Columnar) is a free and open-source column-oriented data storage format. It is similar to the other columnar-storage file formats available in the Hadoop ecosystem such as RCFile and Parquet. It is used by most of the data processing frameworks Apache Spark, Apache Hive, Apache Flink, and Apache Hadoop. In February 2013, the Optimized Row Columnar (ORC) file format was announced by Hortonworks in collaboration with Facebook. A calendar month later, the Apache Parquet format was announced, developed by Cloudera and Twitter. Apache ORC format is widely supported including Amazon Web Services' Glue,Google Cloud Platform's BigQuery, and Pandas (software). == History ==
Google Mobile Services
Google Mobile Services (GMS) is a collection of proprietary applications and application programming interfaces (APIs) services from Google that are typically pre-installed on the majority of Android devices, such as smartphones, tablets, and smart TVs. GMS is not a part of the Android Open Source Project (AOSP), which means an Android manufacturer needs to obtain a license from Google in order to legally pre-install GMS on an Android device. This license is provided by Google without any licensing fees except in the EU. == Core applications == The following are core applications that are part of Google Mobile Services: Google Search Google Chrome YouTube Google Play Google Drive Gmail Google Meet Google Maps Google Photos Google TV YouTube Music === Historically === Google+ Google Hangouts Google Wallet Google Play Magazines Google Play Music Google Play Movies & TV Google Duo == Reception, competitors, and regulators == === FairSearch === Numerous European firms filed a complaint to the European Commission stating that Google had manipulated their power and dominance within the market to push their Services to be used by phone manufacturers. The firms were joined under the name FairSearch, and the main firms included were Microsoft, Expedia, TripAdvisor, Nokia and Oracle. FairSearch's major problem with Google's practices was that they believed Google were forcing phone manufacturers to use their Mobile Services. They claimed Google managed this by asking these manufacturers to sign a contract stating that they must preinstall specific Google Mobile Services, such as Maps, Search and YouTube, in order to get the latest version of Android. Google swiftly responded stating that they "continue to work co-operatively with the European Commission". === Aptoide === The third-party Android app store Aptoide also filed an EU competition complaint against Google once again stating that they are misusing their power within the market. Aptoide alleged that Google was blocking third-party app stores from being on Google Play, as well as blocking Google Chrome from downloading any third-party apps and app stores. As of June 2014, Google had not responded to these allegations. === Abuse of Android dominance === In May 2019, Umar Javeed, Sukarma Thapar, Aaqib Javeed vs. Google LLC & Ors. the Competition Commission of India ordered an antitrust probe against Google for abusing its dominant position with Android to block market rivals. In Prima Facie opinion the commission held that mandatory pre-installation of the entire Google Mobile Services (GMS) suite, under Mobile Application Distribution Agreements (MADA), amounts to the imposition of unfair conditions on the device manufacturers. === EU antitrust ruling === On July 18, 2018, the European Commission fined Google €4.34 billion for breaching EU antitrust rules which resulted in a change of licensing policy for the GMS in the EU. A new paid licensing agreement for smartphones and tablets shipped into the EEA was created. The change is that the GMS is now decoupled from the base Android and will be offered under a separate paid licensing agreement. === Privacy policy === At the same time, Google faced problems with various European data protection agencies, most notably In the United Kingdom and France. The problem they faced was that they had a set of 60 rules merged into one, which allowed Google to "track users more closely". Google once again came out and stated that their new policies still abide by European Union laws. === Android distributions without Google Mobile Services === After surveillance and privacy concerns, several custom android distributions have been implemented, such as GrapheneOS, LineageOS, CalyxOS, iodéOS or /e/OS, and they come either without any GMS installed by default or with microG, that adds a compatibility layer.
GitHub Codespaces
GitHub Codespaces is a cloud-based online integrated development environment developed by GitHub. It allows users to create and manage development environments directly within the browser or through Visual Studio Code desktop. Codespaces is tightly integrated with GitHub repositories and enables on-demand coding, debugging, and testing in a full-featured development container hosted in the cloud. == Features == Instant development environments integrated with GitHub Browser-based and desktop access via Visual Studio Code Configurable Dockerfile or devcontainer.json environments Built-in support for GitHub Copilot, extensions, snippets, and SSH. == Licensing == GitHub Codespaces is proprietary software and available to GitHub users under various subscription plans. Codespaces includes a monthly usage quota for free tier users of 120 hours, and expanded access for GitHub education, Pro, Team, and GitHub Enterprise plans. == GitHub Classroom == GitHub Classroom is an educational tool developed by GitHub to streamline the process of managing programming assignments and coursework. Integrated with GitHub repositories, it allows instructors to distribute starter code, automate grading workflows, and track student progress. GitHub Classroom is widely used in computer science education and supports integration with GitHub Codespaces for cloud-based development environments. == Programming languages supported == == Extensions == Some of the popular extensions include: