A data grid is an architecture or set of services that allows users to access, modify and transfer extremely large amounts of geographically distributed data for research purposes. Data grids make this possible through a host of middleware applications and services that pull together data and resources from multiple administrative domains and then present it to users upon request. The data in a data grid can be located at a single site or multiple sites where each site can be its own administrative domain governed by a set of security restrictions as to who may access the data. Likewise, multiple replicas of the data may be distributed throughout the grid outside their original administrative domain and the security restrictions placed on the original data for who may access it must be equally applied to the replicas. Specifically developed data grid middleware is what handles the integration between users and the data they request by controlling access while making it available as efficiently as possible. == Middleware == Middleware provides all the services and applications necessary for efficient management of datasets and files within the data grid while providing users quick access to the datasets and files. There is a number of concepts and tools that must be available to make a data grid operationally viable. However, at the same time not all data grids require the same capabilities and services because of differences in access requirements, security and location of resources in comparison to users. In any case, most data grids will have similar middleware services that provide for a universal name space, data transport service, data access service, data replication and resource management service. When taken together, they are key to the data grids functional capabilities. === Universal namespace === Since sources of data within the data grid will consist of data from multiple separate systems and networks using different file naming conventions, it would be difficult for a user to locate data within the data grid and know they retrieved what they needed based solely on existing physical file names (PFNs). A universal or unified name space makes it possible to create logical file names (LFNs) that can be referenced within the data grid that map to PFNs. When an LFN is requested or queried, all matching PFNs are returned to include possible replicas of the requested data. The end user can then choose from the returned results the most appropriate replica to use. This service is usually provided as part of a management system known as a Storage Resource Broker (SRB). Information about the locations of files and mappings between the LFNs and PFNs may be stored in a metadata or replica catalogue. The replica catalogue would contain information about LFNs that map to multiple replica PFNs. === Data transport service === Another middleware service is that of providing for data transport or data transfer. Data transport will encompass multiple functions that are not just limited to the transfer of bits, to include such items as fault tolerance and data access. Fault tolerance can be achieved in a data grid by providing mechanisms that ensures data transfer will resume after each interruption until all requested data is received. There are multiple possible methods that might be used to include starting the entire transmission over from the beginning of the data to resuming from where the transfer was interrupted. As an example, GridFTP provides for fault tolerance by sending data from the last acknowledged byte without starting the entire transfer from the beginning. The data transport service also provides for the low-level access and connections between hosts for file transfer. The data transport service may use any number of modes to implement the transfer to include parallel data transfer where two or more data streams are used over the same channel or striped data transfer where two or more steams access different blocks of the file for simultaneous transfer to also using the underlying built-in capabilities of the network hardware or specifically developed protocols to support faster transfer speeds. The data transport service might optionally include a network overlay function to facilitate the routing and transfer of data as well as file I/O functions that allow users to see remote files as if they were local to their system. The data transport service hides the complexity of access and transfer between the different systems to the user so it appears as one unified data source. === Data access service === Data access services work hand in hand with the data transfer service to provide security, access controls and management of any data transfers within the data grid. Security services provide mechanisms for authentication of users to ensure they are properly identified. Common forms of security for authentication can include the use of passwords or Kerberos (protocol). Authorization services are the mechanisms that control what the user is able to access after being identified through authentication. Common forms of authorization mechanisms can be as simple as file permissions. However, need for more stringent controlled access to data is done using Access Control Lists (ACLs), Role-Based Access Control (RBAC) and Tasked-Based Authorization Controls (TBAC). These types of controls can be used to provide granular access to files to include limits on access times, duration of access to granular controls that determine which files can be read or written to. The final data access service that might be present to protect the confidentiality of the data transport is encryption. The most common form of encryption for this task has been the use of SSL while in transport. While all of these access services operate within the data grid, access services within the various administrative domains that host the datasets will still stay in place to enforce access rules. The data grid access services must be in step with the administrative domains access services for this to work. === Data replication service === To meet the needs for scalability, fast access and user collaboration, most data grids support replication of datasets to points within the distributed storage architecture. The use of replicas allows multiple users faster access to datasets and the preservation of bandwidth since replicas can often be placed strategically close to or within sites where users need them. However, replication of datasets and creation of replicas is bound by the availability of storage within sites and bandwidth between sites. The replication and creation of replica datasets is controlled by a replica management system. The replica management system determines user needs for replicas based on input requests and creates them based on availability of storage and bandwidth. All replicas are then cataloged or added to a directory based on the data grid as to their location for query by users. In order to perform the tasks undertaken by the replica management system, it needs to be able to manage the underlying storage infrastructure. The data management system will also ensure the timely updates of changes to replicas are propagated to all nodes. ==== Replication update strategy ==== There are a number of ways the replication management system can handle the updates of replicas. The updates may be designed around a centralized model where a single master replica updates all others, or a decentralized model, where all peers update each other. The topology of node placement may also influence the updates of replicas. If a hierarchy topology is used then updates would flow in a tree like structure through specific paths. In a flat topology it is entirely a matter of the peer relationships between nodes as to how updates take place. In a hybrid topology consisting of both flat and hierarchy topologies updates may take place through specific paths and between peers. ==== Replication placement strategy ==== There are a number of ways the replication management system can handle the creation and placement of replicas to best serve the user community. If the storage architecture supports replica placement with sufficient site storage, then it becomes a matter of the needs of the users who access the datasets and a strategy for placement of replicas. There have been numerous strategies proposed and tested on how to best manage replica placement of datasets within the data grid to meet user requirements. There is not one universal strategy that fits every requirement the best. It is a matter of the type of data grid and user community requirements for access that will determine the best strategy to use. Replicas can even be created where the files are encrypted for confidentiality that would be useful in a research project dealing with medical files. The following section contains several strategies for replica placement. ===== Dynamic replication ===== Dynam
Biorobotics
Biorobotics is an interdisciplinary science that combines the fields of biomedical engineering, cybernetics, and robotics to develop new technologies that integrate biology with mechanical systems to develop more efficient communication, alter genetic information, and create machines that imitate biological systems. == Cybernetics == Cybernetics focuses on the communication and system of living organisms and machines that can be applied and combined with multiple fields of study such as biology, mathematics, computer science, engineering, and much more. This discipline falls under the branch of biorobotics because of its combined field of study between biological bodies and mechanical systems. Studying these two systems allows for advanced analysis on the functions and processes of each system as well as the interactions between them. === History === Cybernetic theory is a concept that has existed for centuries, dating back to the era of Plato where he applied the term to refer to the "governance of people". The term cybernetique is seen in the mid-1800s used by physicist André-Marie Ampère. The term cybernetics was popularized in the late 1940s to refer to a discipline that touched on, but was separate, from established disciplines, such as electrical engineering, mathematics, and biology. === Science === Cybernetics is often misunderstood because of the breadth of disciplines it covers. In the early 20th century, it was coined as an interdisciplinary field of study that combines biology, science, network theory, and engineering. Today, it covers all scientific fields with system related processes. The goal of cybernetics is to analyze systems and processes of any system or systems in an attempt to make them more efficient and effective. === Applications === Cybernetics is used as an umbrella term so applications extend to all systems related scientific fields such as biology, mathematics, computer science, engineering, management, psychology, sociology, art, and more. Cybernetics is used amongst several fields to discover principles of systems, adaptation of organisms, information analysis and much more. == Genetic engineering == Genetic engineering is a field that uses advances in technology to modify biological organisms. Through different methods, scientists are able to alter the genetic material of microorganisms, plants and animals to provide them with desirable traits. For example, making plants grow bigger, better, and faster. Genetic engineering is included in biorobotics because it uses new technologies to alter biology and change an organism's DNA for their and society's benefit. === History === Although humans have modified genetic material of animals and plants through artificial selection for millennia (such as the genetic mutations that developed teosinte into corn and wolves into dogs), genetic engineering refers to the deliberate alteration or insertion of specific genes to an organism's DNA. The first successful case of genetic engineering occurred in 1973 when Herbert Boyer and Stanley Cohen were able to transfer a gene with antibiotic resistance to a bacterium. === Science === There are three main techniques used in genetic engineering: The plasmid method, the vector method and the biolistic method. ==== Plasmid method ==== This technique is used mainly for microorganisms such as bacteria. Through this method, DNA molecules called plasmids are extracted from bacteria and placed in a lab where restriction enzymes break them down. As the enzymes do this, some develop a rough edge that resembles that of a staircase which is considered 'sticky' and capable of reconnecting. These 'sticky' molecules are inserted into another bacteria where they will connect to the DNA rings with the altered genetic material. ==== Vector method ==== The vector method is considered a more precise technique than the plasmid method as it involves the transfer of a specific gene instead of a whole sequence. In the vector method, a specific gene from a DNA strand is isolated through restriction enzymes in a laboratory and is inserted into a vector. Once the vector accepts the genetic code, it is inserted into the host cell where the DNA will be transferred. ==== Biolistic method ==== The biolistic method is typically used to alter the genetic material of plants. This method embeds the desired DNA with a metallic particle such as gold or tungsten in a high speed gun. The particle is then bombarded into the plant. Due to the high velocities and the vacuum generated during bombardment, the particle is able to penetrate the cell wall and inserts the new DNA into the cell. === Applications === Genetic engineering has many uses in the fields of medicine, research and agriculture. In the medical field, genetically modified bacteria are used to produce drugs such as insulin, human growth hormones and vaccines. In research, scientists genetically modify organisms to observe physical and behavioral changes to understand the function of specific genes. In agriculture, genetic engineering is extremely important as it is used by farmers to grow crops that are resistant to herbicides and to insects such as BTCorn. == Bionics == Bionics is a medical engineering field and a branch of biorobotics consisting of electrical and mechanical systems that imitate biological systems, such as prosthetics and hearing aids. It's a portmanteau that combines biology and electronics. === History === The history of bionics goes as far back in time as ancient Egypt. A prosthetic toe made out of wood and leather was found on the foot of a mummy. The time period of the mummy corpse was estimated to be from around the fifteenth century B.C. Bionics can also be witnessed in ancient Greece and Rome. Prosthetic legs and arms were made for amputee soldiers. In the early 16th century, a French military surgeon by the name of Ambroise Pare became a pioneer in the field of bionics. He was known for making various types of upper and lower prosthetics. One of his most famous prosthetics, Le Petit Lorrain, was a mechanical hand operated by catches and springs. During the early 19th century, Alessandro Volta further progressed bionics. He set the foundation for the creation of hearing aids with his experiments. He found that electrical stimulation could restore hearing by inserting an electrical implant to the saccular nerve of a patient's ear. In 1945, the National Academy of Sciences created the Artificial Limb Program, which focused on improving prosthetics since there were a large number of World War II amputee soldiers. Since this creation, prosthetic materials, computer design methods, and surgical procedures have improved, creating modern-day bionics. === Science === ==== Prosthetics ==== The important components that make up modern-day prosthetics are the pylon, the socket, and the suspension system. The pylon is the internal frame of the prosthetic that is made up of metal rods or carbon-fiber composites. The socket is the part of the prosthetic that connects the prosthetic to the person's missing limb. The socket consists of a soft liner that makes the fit comfortable, but also snug enough to stay on the limb. The suspension system is important in keeping the prosthetic on the limb. The suspension system is usually a harness system made up of straps, belts or sleeves that are used to keep the limb attached. The operation of a prosthetic could be designed in various ways. The prosthetic could be body-powered, externally-powered, or myoelectrically powered. Body-powered prosthetics consist of cables attached to a strap or harness, which is placed on the person's functional shoulder, allowing the person to manipulate and control the prosthetic as he or she deems fit. Externally-powered prosthetics consist of motors to power the prosthetic and buttons and switches to control the prosthetic. Myoelectrically powered prosthetics are new, advanced forms of prosthetics where electrodes are placed on the muscles above the limb. The electrodes will detect the muscle contractions and send electrical signals to the prosthetic to move the prosthetic. The downside to this type of prosthetic is that if the sensors are not placed correctly on the limb then the electrical impulses will fail to move the prosthetic. TrueLimb is a specific brand of prosthetics that uses myoelectrical sensors which enable a person to have control of their bionic limb. ==== Hearing aids ==== Four major components make up the hearing aid: the microphone, the amplifier, the receiver, and the battery. The microphone takes in outside sound, turns that sound to electrical signals, and sends those signals to the amplifier. The amplifier increases the sound and sends that sound to the receiver. The receiver changes the electrical signal back into sound and sends the sound into the ear. Hair cells in the ear will sense the vibrations from the sound, convert the vibrations into nerve signals, and send it to the brain so
Microsoft Forms
Microsoft Forms (formerly Office 365 Forms) is an online survey creator, part of Microsoft 365. == Usage == Forms allows users to create surveys and quizzes with automatic marking. The data can be exported to Microsoft Excel, Power BI dashboards and viewed live using the Present feature. == Phishing and fraud == Due to a wave of phishing attacks utilizing Microsoft 365 in early 2021, Microsoft uses algorithms to automatically detect and block phishing attempts with Microsoft Forms. Also, Microsoft advises Forms users not to submit personal information, such as passwords, in a form or survey. It also place a similar advisory underneath the “Submit” button in every form created with Forms, warning users not to give out their password.
The Cancer Imaging Archive
The Cancer Imaging Archive (TCIA) is an open-access database of medical images for cancer research. The site is funded by the National Cancer Institute's (NCI) Cancer Imaging Program, and the contract is operated by the University of Arkansas for Medical Sciences. Data within the archive is organized into collections which typically share a common cancer type and/or anatomical site. The majority of the data consists of CT, MRI, and nuclear medicine (e.g. PET) images stored in DICOM format, but many other types of supporting data are also provided or linked to, in order to enhance research utility. All data are de-identified in order to comply with the Health Insurance Portability and Accountability Act and National Institutes of Health data sharing policies. TCIA resources are intended to support: Development of computer aided diagnosis methods (quantitative imaging) Evaluation of unbiased science reproducibility by acceptable standard statistical methods Research on correlation of clinical diagnostic medical images with digital microscopic histological images Exploratory biomarker research for which imaging is a key element Collaboration between cross-disciplinary investigators where imaging is crucial to research on tumor heterogeneity, between patients and within the tumor; tissue temporal response tracking - objective measurements of tumor progression; imaging genomics and Big Data linkages and analysis (clinical, histo-pathology, genomics) TCIA is recognized as a recommended repository for the Scientific Data, PLOS One, and F1000Research journals. It is also listed in the Registry of Research Data Repositories. == History == Prior to the creation of TCIA, the NCI funded development of the National Biomedical Imaging Archive. NBIA is an open-source Web application which was designed to allow the storage and query of DICOM images. TCIA was subsequently initiated in December 2010 to expand data sharing activities by funding a service component which would help address the technical and policy challenges associated with medical imaging research. TCIA leverages open-source tools such as NBIA and Clinical Trials Processor in order to provide its services. == Organization of the archive == The site content is organized into five categories: About Us - Provides a general overview of the site the organizations responsible for operating it. Share Your Data - Provides an overview of how to apply to upload data to the archive. Access the Archive - Provides information about the available data, methods for accessing that data and system usage metrics. Research Activities - Provides information about major research initiatives being conducted using TCIA data as well as information about publication guidelines. Help - Provides information about how to get support using the archive as well as documentation and data usage policies. == Methods for accessing data == Most collections on the Cancer Imaging Archive can be accessed without an account, but a few are restricted to specific users and therefore require an account to access them. TCIA has several ways to browse, filter, and download data. They include: Downloading the entire contents of a collection in bulk Leveraging the NBIA application to filter or search within or across collections Utilizing the RESTful Application programming interface to filter or search within or across collections === Browsing, bulk downloading and access to supporting data === The home page includes a list of all available collections. Basic information about the data such as the cancer type, cancer location, modalities, and number of subjects are also provided. Clicking on a collection name presents a page which describes the data including its original research purpose, how the data were generated, and how it might be useful to other TCIA users. For example, doi:10.7937/K9/TCIA.2015.L4FRET6Z describes the NSCLC-Radiomics-Genomics Collection. In the lower section of the page there are links to search or download the images and any available supporting data in the Data Access tab. Additional tabs provide information about data versions and how to cite the data if used in publications. Many collections contain additional data types such as genomics, patient demographics, treatment details, and expert analyses of the images. This data is usually only found by browsing the collection pages as opposed to searching in NBIA or using the API. === Filtering or searching with NBIA === On each Collection page and also in the main menu of the site there are links to "Search TCIA". This will load the NBIA application which allows simple, advanced and free text searches. Search results follow the conventional DICOM hierarchy of patient -> study -> series. TCIA provides comprehensive documentation on the various features of the NBIA software. === RESTful API === A number of search and download commands are also available through the API. New iterations on the API are released as new versions, so that existing applications developed against older versions of the API continue to function. == Research activities == A list of known publications based on TCIA data is maintained as a convenience to researchers who might want to investigate how it has been used previously. In addition to peer-reviewed publications there are also several major research initiatives described in the Research Activities section of the site. === The CIP TCGA Radiology Initiative for Radiogenomics Research === A large number of collections contain subjects which were analyzed as part of the NIH/NHGRI database known as The Cancer Genome Atlas (TCGA). This offers researchers the ability to correlate clinical images using shared unique identifiers each study that has in TCGA extensive genomic analysis, digital pathology slides and bulk download of individual demographic data and clinical data. A multi-institutional network of investigators volunteering their time is using the data to develop methods to determine prognosis or predict the response to therapy. TCGA collections are designated by nomenclature shared by the TCGA Data Portal (e.g.: TCGA-BRCA, TCGA-GBM, etc). They are subject to a special publication policy which is unique from the other public data on TCIA. === Challenge competitions === TCIA also provides specific data sets used for "Challenge" competitions such as international digital image-focused professional societies like MICCAI, SPIE, or ISBI. A directory of previous and upcoming challenges is maintained on the site. === Digital object identifiers === To facilitate data sharing, many publications encourage authors to include data citations to the data that the authors used in creating the results described in their scholarly papers. In addition, new journals are now available for describing data collections outright (e.g., Nature Scientific Data). TCIA assigns digital object identifiers (DOIs) to all collections when they are submitted, and also has the ability to create persistent identifiers linked to subsets of data held within TCIA that authors may use for data citations in their scholarly papers.
Color space
A color space is a specific organization of colors. In combination with color profiling supported by various physical devices, it supports reproducible representations of color – whether such representation entails an analog or a digital representation. A color space may be arbitrary, i.e. with physically realized colors assigned to a set of physical color swatches with corresponding assigned color names (including discrete numbers in – for example – the Pantone collection), or structured with mathematical rigor (as with the NCS System, Adobe RGB and sRGB). A "color space" is a useful conceptual tool for understanding the color capabilities of a particular device or digital file. When trying to reproduce color on another device, color spaces can show whether shadow/highlight detail and color saturation can be retained, and by how much either will be compromised. A "color model" is an abstract mathematical model describing the way colors can be represented as tuples of numbers (e.g. triples in RGB or quadruples in CMYK); however, a color model with no associated mapping function to an absolute color space is a more or less arbitrary color system with no connection to any globally understood system of color interpretation. Adding a specific mapping function between a color model and a reference color space establishes within the reference color space a definite "footprint", known as a gamut, and for a given color model, this defines a color space. For example, Adobe RGB and sRGB are two different absolute color spaces, both based on the RGB color model. When defining a color space, the usual reference standard is the CIELAB or CIEXYZ color spaces, which were specifically designed to encompass all colors the average human can see. Since "color space" identifies a particular combination of the color model and the mapping function, the word is often used informally to identify a color model. However, even though identifying a color space automatically identifies the associated color model, this usage is incorrect in a strict sense. For example, although several specific color spaces are based on the RGB color model, there is no such thing as the singular RGB color space. == History == In 1802, Thomas Young postulated the existence of three types of photoreceptors (now known as cone cells) in the eye, each of which was sensitive to a particular range of visible light. Hermann von Helmholtz developed the Young–Helmholtz theory further in 1850: that the three types of cone photoreceptors could be classified as short-preferring (blue), middle-preferring (green), and long-preferring (red), according to their response to the wavelengths of light striking the retina. The relative strengths of the signals detected by the three types of cones are interpreted by the brain as a visible color. But it is not clear that they thought of colors as being points in color space. The color-space concept was likely due to Hermann Grassmann, who developed it in two stages. First, he developed the idea of vector space, which allowed the algebraic representation of geometric concepts in n-dimensional space. Fearnley-Sander (1979) describes Grassmann's foundation of linear algebra as follows: The definition of a linear space (vector space)... became widely known around 1920, when Hermann Weyl and others published formal definitions. In fact, such a definition had been given thirty years previously by Peano, who was thoroughly acquainted with Grassmann's mathematical work. Grassmann did not put down a formal definition—the language was not available—but there is no doubt that he had the concept. With this conceptual background, in 1853, Grassmann published a theory of how colors mix; it and its three color laws are still taught, as Grassmann's law. As noted first by Grassmann... the light set has the structure of a cone in the infinite-dimensional linear space. As a result, a quotient set (with respect to metamerism) of the light cone inherits the conical structure, which allows color to be represented as a convex cone in the 3- D linear space, which is referred to as the color cone. == Examples == Colors can be created in printing with color spaces based on the CMYK color model, using the subtractive primary colors of pigment (cyan, magenta, yellow, and key [black]). To create a three-dimensional representation of a given color space, we can assign the amount of magenta color to the representation's X axis, the amount of cyan to its Y axis, and the amount of yellow to its Z axis. The resulting 3-D space provides a unique position for every possible color that can be created by combining those three pigments. Colors can be created on computer monitors with color spaces based on the RGB color model, using the additive primary colors (red, green, and blue). A three-dimensional representation would assign each of the three colors to the X, Y, and Z axes. Colors generated on a given monitor will be limited by the reproduction medium, such as the phosphor (in a CRT monitor) or filters and backlight (LCD monitor). Another way of creating colors on a monitor is with an HSL or HSV color model, based on hue, saturation, brightness (value/lightness). With such a model, the variables are assigned to cylindrical coordinates. Many color spaces can be represented as three-dimensional values in this manner, but some have more, or fewer dimensions, and some, such as Pantone, cannot be represented in this way at all. == Conversion == Color space conversion is the translation of the representation of a color from one basis to another. This typically occurs in the context of converting an image that is represented in one color space to another color space, the goal being to make the translated image look as similar as possible to the original. == RGB density == The RGB color model is implemented in different ways, depending on the capabilities of the system used. The most common incarnation in general use as of 2021 is the 24-bit implementation, with 8 bits, or 256 discrete levels of color per channel. Any color space based on such a 24-bit RGB model is thus limited to a range of 256×256×256 ≈ 16.7 million colors. Some implementations use 16 bits per component for 48 bits total, resulting in the same gamut with a larger number of distinct colors. This is especially important when working with wide-gamut color spaces (where most of the more common colors are located relatively close together), or when a large number of digital filtering algorithms are used consecutively. The same principle applies for any color space based on the same color model, but implemented at different bit depths. == Lists == CIE 1931 XYZ color space was one of the first attempts to produce a color space based on measurements of human color perception (earlier efforts were by James Clerk Maxwell, König & Dieterici, and Abney at Imperial College) and it is the basis for almost all other color spaces. The CIERGB color space is a linearly-related companion of CIE XYZ. Additional derivatives of CIE XYZ include the CIELUV, CIEUVW, and CIELAB. === Generic === RGB uses additive color mixing, because it describes what kind of light needs to be emitted to produce a given color. RGB stores individual values for red, green and blue. RGBA is RGB with an additional channel, alpha, to indicate transparency. Common color spaces based on the RGB model include sRGB, Adobe RGB, ProPhoto RGB, scRGB, and CIE RGB. CMYK uses subtractive color mixing used in the printing process, because it describes what kind of inks need to be applied so the light reflected from the substrate and through the inks produces a given color. One starts with a white substrate (canvas, page, etc.), and uses ink to subtract color from white to create an image. CMYK stores ink values for cyan, magenta, yellow and black. There are many CMYK color spaces for different sets of inks, substrates, and press characteristics (which change the dot gain or transfer function for each ink and thus change the appearance). YIQ was formerly used in NTSC (North America, Japan and elsewhere) television broadcasts for historical reasons. This system stores a luma value roughly analogous to (and sometimes incorrectly identified as) luminance, along with two chroma values as approximate representations of the relative amounts of blue and red in the color. It is similar to the YUV scheme used in most video capture systems and in PAL (Australia, Europe, except France, which uses SECAM) television, except that the YIQ color space is rotated 33° with respect to the YUV color space and the color axes are swapped. The YDbDr scheme used by SECAM television is rotated in another way. YPbPr is a scaled version of YUV. It is most commonly seen in its digital form, YCbCr, used widely in video and image compression schemes such as MPEG and JPEG. xvYCC is an international digital video color space standard published by the IEC (IEC 61966-2-4). It is based on the ITU BT.601 and BT.709
Flo (app)
Flo is a period-tracking app that provides menstrual cycle, ovulation and pregnancy tracking as well as perimenopause symptom tracking that was developed by Flo Health, Inc. It has over 380 million downloads worldwide and over 70 million monthly active users as of November 2024. In mid-2024, it reached unicorn status, and became Europe’s first femtech unicorn. The company has been accused of sharing users' sensitive health data with third parties without consent and misleading its users about data practices. == History == Flo Health, Inc. was co-founded in 2015 by Dmitry and Yuri Gurski, in Belarus. Their backgrounds helped build the first version of the software having experience in other fitness and health apps. Dmitry serves as the company's CEO. The company's development hubs are in London, Amsterdam and Vilnius. In 2016, the company raised $1 million in seed round funding from Flint Capital and Haxus Venture Fund. In 2017, Flo received an investment of $5 million from Flint Capital and model Natalia Vodianova with Vodianova helping develop an awareness campaign for the company. In 2018, Flo received an investment of $6 million from Mangrove Capital Partners, with participation from Flint Capital and Haxus, giving the company a valuation of $200 million. In mid-2019, Flo received an additional investment of $7.5 million led by Founders Fund. In 2020, the Federal Trade Commission alleged that Flo had misled users about its handling of health information to third parties including Google, Facebook, AppsFlyer, and Flurry since 2016. These allegations followed a 2019 report by The Wall Street Journal in reference to Facebook. The company reached a settlement in 2021 and was required to notify users of how their personal information was shared and obtain permission before any further information was shared. The agreement also required that Flo to undertake an independent privacy audit which it completed in March 2022. In early September 2021, Flo announced it closed $50M in a Series B financing, bringing the total capital raised to $65 million and company valuation to $800M led by VNV Global and Target Global. In March 2024, the Supreme Court of British Columbia certified a class action suit against Flo for sharing intimate data with Facebook and other third parties without user knowledge. In July 2024, Flo announced it raised more than $200M in Series C financing from General Atlantic bringing its valuation beyond $1 billion. As of November 2024, the app had over 380 million downloads world wide, and over 70 million monthly active users. In 2025, Flo adopted a data intelligence platform from Databricks to power its analytics and AI features, allowing users personalized cycle predictions. In 2025, a class action lawsuit in California was settled for $56 million with Flo paying $8 million and Google paying $48 million. == Features and privacy == Flo was initially created as a period and ovulation tracking application. It now provides reminders of upcoming menstrual cycles and a place to record various other health symptoms such as contraceptive methods, vaginal discharge (leukorrhea), water intake, pains, mood swings, and sexual activity. The application is available on iOS and Android. Flo is free to download and the free basic version gives you access to period and ovulation tracking and predictions, symptom tracking, cycle history, and anonymous mode. In Pregnancy mode, the app provides tracking features and educational material for pregnancy. In October 2023, Flo launched Flo for Partners, a feature that allows users to share their Flo data with their partner. In September 2022, as a response to Roe v. Wade being overturned, Flo sped up the release of a feature called "Anonymous Mode". Flo said this mode allows users to access the app without any personal identifiers such as name, email address, or technical identifiers being associated with their health data. Flo said it uses a technology called Oblivious HTTP to help protect user privacy in Anonymous Mode. == Recognition == Flo was named to Bloomberg’s Top 25 UK Startups to Watch for 2024. Flo's Anonymous Mode feature was recognized on both Fast Company's World Changing Ideas 2023 and TIME's Best Inventions List 2023. Flo is a CES 2019 Innovation Awards Honoree in the Software and Mobile Applications category.
Floyd–Steinberg dithering
Floyd–Steinberg dithering is an image dithering algorithm first published in 1976 by Robert W. Floyd and Louis Steinberg. It is commonly used by image manipulation software, for example, when converting an image from a Truecolor 24-bit PNG format into a GIF format, which is restricted to a maximum of 256 colors. == Implementation == The algorithm achieves dithering using error diffusion, meaning it pushes (adds) the residual quantization error of a pixel onto its neighboring pixels, to be quantized after. It spreads the debt out according to the distribution (shown as a map of the neighboring pixels): [ ∗ 7 16 … … 3 16 5 16 1 16 … ] {\displaystyle {\begin{bmatrix}&&&{\frac {\displaystyle 7}{\displaystyle 16}}&\ldots \\\ldots &{\frac {\displaystyle 3}{\displaystyle 16}}&{\frac {\displaystyle 5}{\displaystyle 16}}&{\frac {\displaystyle 1}{\displaystyle 16}}&\ldots \\\end{bmatrix}}} The pixel indicated with a star () indicates the pixel currently being scanned, and the blank pixels are the previously scanned pixels. The specific values (7/16, 3/16, 5/16, 1/16) were originally found by trial-and-error, "guided by the desire to have a region of desired density 0.5 come out as a checkerboard pattern". The algorithm scans the image from left to right, top to bottom, quantizing pixel values one by one. Each time, the quantization error is transferred to the neighboring pixels, while not affecting the pixels that already have been quantized. Hence, if a number of pixels have been rounded downwards, it becomes more likely that the next pixel is rounded upwards, such that on average, the quantization error is close to zero. The diffusion coefficients have the property that if the original pixel values are exactly halfway in between the nearest available colors, the dithered result is a checkerboard pattern. For example, 50% grey data could be dithered as a black-and-white checkerboard pattern. For optimal dithering, the counting of quantization errors should be in sufficient accuracy to prevent rounding errors from affecting the result. For correct results, all values should be linearized first, rather than operating directly on sRGB values as is common for images stored on computers. In some implementations, the horizontal direction of scan alternates between lines; this is called "serpentine scanning" or boustrophedon transform dithering. The algorithm described above is in the following pseudocode. This works for any approximately linear encoding of pixel values, such as 8-bit integers, 16-bit integers or real numbers in the range [0, 1]. for each y from top to bottom do for each x from left to right do oldpixel := pixels[x][y] newpixel := find_closest_palette_color(oldpixel) pixels[x][y] := newpixel quant_error := oldpixel - newpixel pixels[x + 1][y ] := pixels[x + 1][y ] + quant_error × 7 / 16 pixels[x - 1][y + 1] := pixels[x - 1][y + 1] + quant_error × 3 / 16 pixels[x ][y + 1] := pixels[x ][y + 1] + quant_error × 5 / 16 pixels[x + 1][y + 1] := pixels[x + 1][y + 1] + quant_error × 1 / 16 When converting grayscale pixel values from a high to a low bit depth (e.g. 8-bit grayscale to 1-bit black-and-white), find_closest_palette_color() may perform just a simple rounding, for example: find_closest_palette_color(oldpixel) = round(oldpixel / 255) The pseudocode can result in pixel values exceeding the valid values (such as greater than 255 in 8-bit grayscale images). Such values should ideally be handled by the find_closest_palette_color() function, rather than clipping the intermediate values, since a subsequent error may bring the value back into range. However, if fixed-width integers are used, wrapping of intermediate values would cause inversion of black and white, and so should be avoided. The find_closest_palette_color() implementation is nontrivial for a palette that is not evenly distributed, however small inaccuracies in selecting the correct palette color have minimal visual impact due to error being propagated to future pixels. A nearest neighbor search in 3D is frequently used.