The Cancer Imaging Archive (TCIA) is an open-access database of medical images for cancer research. The site is funded by the National Cancer Institute's (NCI) Cancer Imaging Program, and the contract is operated by the University of Arkansas for Medical Sciences. Data within the archive is organized into collections which typically share a common cancer type and/or anatomical site. The majority of the data consists of CT, MRI, and nuclear medicine (e.g. PET) images stored in DICOM format, but many other types of supporting data are also provided or linked to, in order to enhance research utility. All data are de-identified in order to comply with the Health Insurance Portability and Accountability Act and National Institutes of Health data sharing policies. TCIA resources are intended to support: Development of computer aided diagnosis methods (quantitative imaging) Evaluation of unbiased science reproducibility by acceptable standard statistical methods Research on correlation of clinical diagnostic medical images with digital microscopic histological images Exploratory biomarker research for which imaging is a key element Collaboration between cross-disciplinary investigators where imaging is crucial to research on tumor heterogeneity, between patients and within the tumor; tissue temporal response tracking - objective measurements of tumor progression; imaging genomics and Big Data linkages and analysis (clinical, histo-pathology, genomics) TCIA is recognized as a recommended repository for the Scientific Data, PLOS One, and F1000Research journals. It is also listed in the Registry of Research Data Repositories. == History == Prior to the creation of TCIA, the NCI funded development of the National Biomedical Imaging Archive. NBIA is an open-source Web application which was designed to allow the storage and query of DICOM images. TCIA was subsequently initiated in December 2010 to expand data sharing activities by funding a service component which would help address the technical and policy challenges associated with medical imaging research. TCIA leverages open-source tools such as NBIA and Clinical Trials Processor in order to provide its services. == Organization of the archive == The site content is organized into five categories: About Us - Provides a general overview of the site the organizations responsible for operating it. Share Your Data - Provides an overview of how to apply to upload data to the archive. Access the Archive - Provides information about the available data, methods for accessing that data and system usage metrics. Research Activities - Provides information about major research initiatives being conducted using TCIA data as well as information about publication guidelines. Help - Provides information about how to get support using the archive as well as documentation and data usage policies. == Methods for accessing data == Most collections on the Cancer Imaging Archive can be accessed without an account, but a few are restricted to specific users and therefore require an account to access them. TCIA has several ways to browse, filter, and download data. They include: Downloading the entire contents of a collection in bulk Leveraging the NBIA application to filter or search within or across collections Utilizing the RESTful Application programming interface to filter or search within or across collections === Browsing, bulk downloading and access to supporting data === The home page includes a list of all available collections. Basic information about the data such as the cancer type, cancer location, modalities, and number of subjects are also provided. Clicking on a collection name presents a page which describes the data including its original research purpose, how the data were generated, and how it might be useful to other TCIA users. For example, doi:10.7937/K9/TCIA.2015.L4FRET6Z describes the NSCLC-Radiomics-Genomics Collection. In the lower section of the page there are links to search or download the images and any available supporting data in the Data Access tab. Additional tabs provide information about data versions and how to cite the data if used in publications. Many collections contain additional data types such as genomics, patient demographics, treatment details, and expert analyses of the images. This data is usually only found by browsing the collection pages as opposed to searching in NBIA or using the API. === Filtering or searching with NBIA === On each Collection page and also in the main menu of the site there are links to "Search TCIA". This will load the NBIA application which allows simple, advanced and free text searches. Search results follow the conventional DICOM hierarchy of patient -> study -> series. TCIA provides comprehensive documentation on the various features of the NBIA software. === RESTful API === A number of search and download commands are also available through the API. New iterations on the API are released as new versions, so that existing applications developed against older versions of the API continue to function. == Research activities == A list of known publications based on TCIA data is maintained as a convenience to researchers who might want to investigate how it has been used previously. In addition to peer-reviewed publications there are also several major research initiatives described in the Research Activities section of the site. === The CIP TCGA Radiology Initiative for Radiogenomics Research === A large number of collections contain subjects which were analyzed as part of the NIH/NHGRI database known as The Cancer Genome Atlas (TCGA). This offers researchers the ability to correlate clinical images using shared unique identifiers each study that has in TCGA extensive genomic analysis, digital pathology slides and bulk download of individual demographic data and clinical data. A multi-institutional network of investigators volunteering their time is using the data to develop methods to determine prognosis or predict the response to therapy. TCGA collections are designated by nomenclature shared by the TCGA Data Portal (e.g.: TCGA-BRCA, TCGA-GBM, etc). They are subject to a special publication policy which is unique from the other public data on TCIA. === Challenge competitions === TCIA also provides specific data sets used for "Challenge" competitions such as international digital image-focused professional societies like MICCAI, SPIE, or ISBI. A directory of previous and upcoming challenges is maintained on the site. === Digital object identifiers === To facilitate data sharing, many publications encourage authors to include data citations to the data that the authors used in creating the results described in their scholarly papers. In addition, new journals are now available for describing data collections outright (e.g., Nature Scientific Data). TCIA assigns digital object identifiers (DOIs) to all collections when they are submitted, and also has the ability to create persistent identifiers linked to subsets of data held within TCIA that authors may use for data citations in their scholarly papers.
Adobe After Effects
Adobe After Effects is a digital effects, motion graphics, and compositing application developed by Adobe Inc.; it is used for animation and in the post-production process of film making, video games and television production. Among other things, After Effects can be used for keying, tracking, compositing, and animation. It also functions as a very basic non-linear editor, audio editor, and media transcoder. In 2019, the program won an Academy Award for scientific and technical achievement. == History == After Effects was originally created by David Herbstman, David Simons, Daniel Wilk, David M. Cotter, and Russell Belfer at the Company of Science and Art in Providence, Rhode Island. The first two versions of the software, 1.0 (January 1993) and 1.1, were released there by the company. CoSA with After Effects was acquired by Aldus Corporation in July 1993, which in turn was acquired by Adobe in 1994. Adobe acquired PageMaker as well. Adobe's first new release of After Effects was version 3.0. == Third-party integrations == After Effects functionality can be extended through a variety of third-party integrations. The most common integrations are: plug-ins, scripts, and extensions. === Plug-ins === Plug-ins are predominantly written in C or C++ and extend the functionality of After Effects, allowing for more advanced features such as particle systems, physics engines, 3D effects, and the ability to bridge the gap between After Effects and another. === Scripts === After Effects Scripts are a series of commands written in both JavaScript and the ExtendScript language. After Effects Scripts, unlike plug-ins, can only access the core functionality of After Effects. Scripts are often developed to automate repetitive tasks, to simplify complex After Effects features, or to perform complex calculations that would otherwise take a long time to complete. Scripts can also use some functionality not directly exposed through the graphical user interface. === Extensions === After Effects Extensions offer the ability to extend After Effects functionality through modern web development technologies like HTML5, and Node.js, without the need for C++. After Effects Extensions make use of Adobe's Common Extensibility Platform or CEP Panels, which means they can be built to interact with other Adobe CC apps.
Strong secrecy
Strong secrecy is a term used in formal proof-based cryptography for making propositions about the security of cryptographic protocols. It is a stronger notion of security than syntactic (or weak) secrecy. Strong secrecy is related with the concept of semantic security or indistinguishability used in the computational proof-based approach. Bruno Blanchet provides the following definition for strong secrecy: Strong secrecy means that an adversary cannot see any difference when the value of the secret changes For example, if a process encrypts a message m an attacker can differentiate between different messages, since their ciphertexts will be different. Thus m is not a strong secret. If however, probabilistic encryption were used, m would be a strong secret. The randomness incorporated into the encryption algorithm will yield different ciphertexts for the same value of m.
Outfit of the day
Outfit of the day (commonly abbreviated OOTD) is a phrase used online by users sharing what outfits (or "fits") they wear on a particular day or occasion. The video or post often mentions where each article of clothing, shoes, jewelry, and other accessories is from. OOTD posts are typically found on social media websites, such as Tumblr, Instagram, and Pinterest, and OOTD videos on YouTube and TikTok. Motives for sharing OOTD content vary, from encouraging viewers to buy a certain product, showing off personal style, or giving outfit inspiration. == History == "Outfit of the Day" videos started as early as 2010 but gained popularity in 2019. By 2016, the hashtag "OOTD" on Instagram had over 80 million posts. OOTD videos have become popular with the average internet user, as they express one's fashion sense and style to their followers. == Use in marketing == Brands will use famous influencers to promote their products using the "outfit of the day" tactic in hopes that users will buy the product to emulate the influencer. This tactic has increased sales for many brands. Creators of OOTD content can also profit, often through brand deals or affiliate links. Vogue has a recurring segment on YouTube that shows "Every outfit (fill in celebrity name here) wears in a week." == Variants == A variant is "outfit(s) of the week" (OOTW), where a user will share multiple outfits to be worn over the course of several days or a week. OOTDs are often seen in "Get ready with me" (GRWM) videos, where a user films their morning routine. In these videos, the filmers talk about their plans for the day, what makeup products they are using to get ready, and the "Outfit of the day" they are wearing. == Criticism == Some fashion writers have suggested that the proliferation of OOTD content encourages people to buy new clothing rather than to wear already owned items. Some stylists have also proposed that OOTD content encourages users to follow trends rather than explore and find their own style.
Backdoor (computing)
A backdoor is a typically covert method of bypassing normal authentication or encryption in a computer, product, embedded device (e.g. a home router), or its embodiment (e.g. part of a cryptosystem, algorithm, chipset, or even a "homunculus computer"—a tiny computer-within-a-computer such as that found in Intel's AMT technology). Backdoors are most often used for securing remote access to a computer, or obtaining access to plaintext in cryptosystems. From there it may be used to gain access to privileged information like passwords, corrupt or delete data on hard drives, or transfer information within compromised networks. In the United States, the 1994 Communications Assistance for Law Enforcement Act forces internet providers to provide backdoors for government authorities. In 2024, the U.S. government realized that China had been tapping communications in the U.S. using that infrastructure for months, or perhaps longer; China recorded presidential candidate campaign office phone calls—including employees of the then-vice president of the nation, and of the candidates themselves. A backdoor may take the form of a hidden part of a program, a separate program (e.g. Back Orifice may subvert the system through a rootkit), code in the firmware of the hardware, or parts of an operating system such as Windows, for example, device drivers. Trojan horses can be used to create vulnerabilities in a device. A Trojan horse may appear to be an entirely legitimate program, but when executed, it triggers an activity that may install a backdoor. Although some are secretly installed, other backdoors are deliberate and widely known. These kinds of backdoors have "legitimate" uses such as providing the manufacturer with a way to restore user passwords. Many systems that store information within the cloud fail to create accurate security measures. If many systems are connected within the cloud, hackers can gain access to all other platforms through the most vulnerable system. Default passwords (or other default credentials) can function as backdoors if they are not changed by the user. Some debugging features can also act as backdoors if they are not removed in the release version. In 1993, the United States government attempted to deploy an encryption system, the Clipper chip, with an explicit backdoor for law enforcement and national security access. The chip was unsuccessful. Recent proposals to counter backdoors include creating a database of backdoors' triggers and then using neural networks to detect them. == Overview == The threat of backdoors surfaced when multiuser and networked operating systems became widely adopted. Petersen and Turn discussed computer subversion in a paper published in the proceedings of the 1967 AFIPS Conference. They noted a class of active infiltration attacks that use "trapdoor" entry points into the system to bypass security facilities and permit direct access to data. The use of the word trapdoor here clearly coincides with more recent definitions of a backdoor. However, since the advent of public key cryptography the term trapdoor has acquired a different meaning (see: Trapdoor function), and thus the term "backdoor" is now preferred, only after the term trapdoor went out of use. More generally, such security breaches were discussed at length in a RAND Corporation task force report published under DARPA sponsorship by J.P. Anderson and D.J. Edwards in 1970. While initially targeting the computer vision domain, backdoor attacks have expanded to encompass various other domains, including text, audio, ML-based computer-aided design, and ML-based wireless signal classification. Additionally, vulnerabilities in backdoors have been demonstrated in deep generative models, reinforcement learning (e.g., AI GO), and deep graph models. These broad-ranging potential risks have prompted concerns from national security agencies regarding their potentially disastrous consequences. A backdoor in a login system might take the form of a hard coded user and password combination which gives access to the system. An example of this sort of backdoor was used as a plot device in the 1983 film WarGames, in which the architect of the "WOPR" computer system had inserted a hardcoded password-less account which gave the user access to the system, and to undocumented parts of the system (in particular, a video game-like simulation mode and direct interaction with the artificial intelligence). Although the number of backdoors in systems using proprietary software (software whose source code is not publicly available) is not widely credited, they are nevertheless frequently exposed. Programmers have even succeeded in secretly installing large amounts of benign code as Easter eggs in programs, although such cases may involve official forbearance, if not actual permission. == Examples == === Worms === Many computer worms, such as Sobig and Mydoom, install a backdoor on the affected computer (generally a PC on broadband running Microsoft Windows and Microsoft Outlook). Such backdoors appear to be installed so that spammers can send junk e-mail from the infected machines. Others, such as the Sony/BMG rootkit, placed secretly on millions of music CDs through late 2005, are intended as DRM measures—and, in that case, as data-gathering agents, since both surreptitious programs they installed routinely contacted central servers. A sophisticated attempt to plant a backdoor in the Linux kernel, exposed in November 2003, added a small and subtle code change by subverting the revision control system. In this case, a two-line change appeared to check root access permissions of a caller to the sys_wait4 function, but because it used assignment = instead of equality checking ==, it actually granted permissions to the system. This difference is easily overlooked, and could even be interpreted as an accidental typographical error, rather than an intentional attack. In January 2014, a backdoor was discovered in certain Samsung Android products, like the Galaxy devices. The Samsung proprietary Android versions are fitted with a backdoor that provides remote access to the data stored on the device. In particular, the Samsung Android software that is in charge of handling the communications with the modem, using the Samsung IPC protocol, implements a class of requests known as remote file server (RFS) commands, that allows the backdoor operator to perform via modem remote I/O operations on the device hard disk or other storage. As the modem is running Samsung proprietary Android software, it is likely that it offers over-the-air remote control that could then be used to issue the RFS commands and thus to access the file system on the device. === Object code backdoors === Harder to detect backdoors involve modifying object code, rather than source code—object code is much harder to inspect, as it is designed to be machine-readable, not human-readable. These backdoors can be inserted either directly in the on-disk object code, or inserted at some point during compilation, assembly linking, or loading—in the latter case the backdoor never appears on disk, only in memory. Object code backdoors are difficult to detect by inspection of the object code, but are easily detected by simply checking for changes (differences), notably in length or in checksum, and in some cases can be detected or analyzed by disassembling the object code. Further, object code backdoors can be removed (assuming source code is available) by simply recompiling from source on a trusted system. Thus for such backdoors to avoid detection, all extant copies of a binary must be subverted, and any validation checksums must also be compromised, and source must be unavailable, to prevent recompilation. Alternatively, these other tools (length checks, diff, checksumming, disassemblers) can themselves be compromised to conceal the backdoor, for example detecting that the subverted binary is being checksummed and returning the expected value, not the actual value. To conceal these further subversions, the tools must also conceal the changes in themselves—for example, a subverted checksummer must also detect if it is checksumming itself (or other subverted tools) and return false values. This leads to extensive changes in the system and tools being needed to conceal a single change. As object code can be regenerated by recompiling (reassembling, relinking) the original source code, making a persistent object code backdoor (without modifying source code) requires subverting the compiler itself—so that when it detects that it is compiling the program under attack it inserts the backdoor—or alternatively the assembler, linker, or loader. As this requires subverting the compiler, this in turn can be fixed by recompiling the compiler, removing the backdoor insertion code. This defense can in turn be subverted by putting a source meta-backdoor in the compiler, so that when it detects that it is compiling itself
Manifold hypothesis
The manifold hypothesis posits that many high-dimensional data sets that occur in the real world actually lie along low-dimensional latent manifolds inside that high-dimensional space. As a consequence of the manifold hypothesis, many data sets that appear to initially require many variables to describe, can actually be described by a comparatively small number of variables, linked to the local coordinate system of the underlying manifold. It is suggested that this principle underpins the effectiveness of machine learning algorithms in describing high-dimensional data sets by considering a few common features. The manifold hypothesis is related to the effectiveness of nonlinear dimensionality reduction techniques in machine learning. Many techniques of dimensional reduction make the assumption that data lies along a low-dimensional submanifold, such as manifold sculpting, manifold alignment, and manifold regularization. The major implications of this hypothesis is that Machine learning models only have to fit relatively simple, low-dimensional, highly structured subspaces within their potential input space (latent manifolds). Within one of these manifolds, it's always possible to interpolate between two inputs, that is to say, morph one into another via a continuous path along which all points fall on the manifold. The ability to interpolate between samples is the key to generalization in deep learning. == The information geometry of statistical manifolds == An empirically-motivated approach to the manifold hypothesis focuses on its correspondence with an effective theory for manifold learning under the assumption that robust machine learning requires encoding the dataset of interest using methods for data compression. This perspective gradually emerged using the tools of information geometry thanks to the coordinated effort of scientists working on the efficient coding hypothesis, predictive coding and variational Bayesian methods. The argument for reasoning about the information geometry on the latent space of distributions rests upon the existence and uniqueness of the Fisher information metric. In this general setting, we are trying to find a stochastic embedding of a statistical manifold. From the perspective of dynamical systems, in the big data regime this manifold generally exhibits certain properties such as homeostasis: We can sample large amounts of data from the underlying generative process. Machine Learning experiments are reproducible, so the statistics of the generating process exhibit stationarity. In a sense made precise by theoretical neuroscientists working on the free energy principle, the statistical manifold in question possesses a Markov blanket.
Cipher device
A cipher device was a term used by the US military in the first half of the 20th century to describe a manually operated cipher equipment that converted the plaintext into ciphertext or vice versa. A similar term, cipher machine, was used to describe the cipher equipment that required external power for operation. Cipher box or crypto box is a physical cryptographic device used to encrypt and decrypt messages between plaintext (unencrypted) and ciphertext (encrypted or secret) forms. The ciphertext is suitable for transmission over a channel, such as radio, that might be observed by an adversary the communicating parties wish to conceal the plaintext from.