Karsten Borgwardt (born 1980) is a German computer scientist and biologist specializing in machine learning and computational biology. Since February 2023, he has been a director at the Max Planck Institute of Biochemistry in Martinsried, Germany, where he leads the Department of Machine Learning and Systems Biology. == Education and career == Borgwardt was born in Kaiserslautern. He obtained a Diplom (equivalent to a master’s degree) in computer science from LMU Munich in 2004 and a Master of Science in biology from the University of Oxford in 2003. In 2007, he obtained his PhD from LMU Munich in computer science. Following a postdoctoral position at the University of Cambridge, he became a research group leader for machine learning and computational biology at the Max Planck Institute for Biological Cybernetics and the former Max Planck Institute for Developmental Biology in Tübingen in 2008. In 2011, Borgwardt was appointed professor of data mining in the life sciences at the University of Tübingen. In 2014, he joined ETH Zurich as an associate professor in the Department of Biosystems Science and Engineering (D-BSSE) and was promoted to full professor in 2017. During his tenure at ETH Zurich, he coordinated significant research programs, including two Marie Curie Innovative Training Networks and the Personalized Swiss Sepsis Study, focusing on the prediction of sepsis using machine learning. In 2023, he was appointed as Scientific Member of the Max Planck Society and as Director at the Max Planck Institute of Biochemistry in Martinsried. == Research contributions == Borgwardt’s research integrates big data analysis with biomedical research. He develops novel machine learning algorithms to detect patterns and statistical dependencies in large biological and medical datasets. His work aims to enable the automatic generation of new knowledge from big data and to understand the relationship between the function of biological systems and their molecular properties, which is fundamental for personalized medicine. == Awards and honors == During his studies, he was a scholar of the Stiftung Maximilianeum, and the Bavarian Foundation for the Promotion of the Gifted. Borgwardt received scholarships from the Studienstiftung des deutschen Volkes in 2002 and 2007. His PhD dissertation received the Heinz Schwärtzel Dissertation Award for Foundations of Computer Science in 2007. As a professor in Tübingen, he was awarded the Alfried-Krupp-Förderpreis for Young Professors in 2013. In 2015, he received an SNSF Starting Grant. In 2014, 2015 and 2016, he was listed in “Top 40 under 40” in Germany rankings selected by Capital magazine. In 2018, Borgwardt was named among “25 individuals who have the potential to shape the next 25 years” by Focus magazine. In 2023, Borgwardt received an honorary professorship from LMU Munich by the Faculty of Chemistry and Pharmacy. Publications from Borgwardt's group have received the Outstanding Student Paper Award in NIPS in 2009, the SIB Graduate Paper Award in 2020 and SIB Remarkable Output Awards in 2020 and 2021 from the Swiss Institute of Bioinformatics (SIB). == Selected publications == Weisfeiler-Lehman Graph Kernels (’‘Journal of Machine Learning Research’’, 2011): Introduced an efficient graph kernel based on the Weisfeiler-Lehman algorithm. “Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning” (’‘Nature Medicine’’, 2022): showcased the feasibility of predicting antimicrobial resistance from readily collected mass spectrometry data in the hospital. The new method is able to identify antibiotic resistance 24 hours earlier than previous methods.
Predictive text
Predictive text is an input technology used where one key or button represents many letters, such as on the physical numeric keypads of mobile phones and in accessibility technologies. Each key press results in a prediction rather than repeatedly sequencing through the same group of "letters" it represents, in the same, invariable order. Predictive text could allow for an entire word to be input by a single keypress. Predictive text makes efficient use of fewer device keys to input writing into a text message, an e-mail, an address book, a calendar, and the like. The most widely used, general, predictive text systems are T9, iTap, eZiText, and LetterWise/WordWise. There are many ways to build a device that predicts text, but all predictive text systems have initial linguistic settings that offer predictions that are re-prioritized to adapt to each user. This learning adapts, by way of the device memory, to a user's disambiguating feedback that results in corrective key presses, such as pressing a "next" key to get to the intention. Most predictive text systems have a user database to facilitate this process. Theoretically the number of keystrokes required per desired character in the finished writing is, on average, comparable to using a keyboard. This is approximately true provided that all words used are in its database, punctuation is ignored, and no input mistakes are made when typing or spelling. The theoretical keystrokes per character, KSPC, of a keyboard is KSPC=1.00, and of multi-tap is KSPC=2.03. Eatoni's LetterWise is a predictive multi-tap hybrid, which when operating on a standard telephone keypad achieves KSPC=1.15 for English. The choice of which predictive text system is the best to use involves matching the user's preferred interface style, the user's level of learned ability to operate predictive text software, and the user's efficiency goal. There are various levels of risk in predictive text systems, versus multi-tap systems, because the predicted text that is automatically written provides the speed and mechanical efficiency benefit, which, if the user is not careful to review, results in transmitting misinformation. Predictive text systems take time to learn to use well, and so generally, a device's system has user options to set up the choice of multi-tap or any one of several schools of predictive text methods. == Background == Short message service (SMS) permits a mobile phone user to send text messages (also called messages, SMSes, texts, and txts) as a short message. The most common system of SMS text input is referred to as "multi-tap". Using multi-tap, a key is pressed multiple times to access the list of letters on that key. For instance, pressing the "2" key once displays an "a", twice displays a "b" and three times displays a "c". To enter two successive letters that are on the same key, the user must either pause or hit a "next" button. A user can type by pressing an alphanumeric keypad without looking at the electronic equipment display. Thus, multi-tap is easy to understand and can be used without any visual feedback. However, multi-tap is not very efficient, requiring potentially many keystrokes to enter a single letter. In ideal predictive text entry, all words used are in the dictionary, punctuation is ignored, no spelling mistakes are made, and no typing mistakes are made. The ideal dictionary would include all slang, proper nouns, abbreviations, URLs, foreign-language words and other user-unique words. This ideal circumstance gives predictive text software a reduction in the number of key strokes a user is required to enter a word. The user presses the number corresponding to each letter. As long as the word exists in the predictive text dictionary or is correctly disambiguated by non-dictionary systems, it will appear. For instance, pressing "4663" will typically be interpreted as the word good, provided that a linguistic database in English is currently in use, though alternatives such as home, hood and hoof are also valid interpretations of the sequence of key strokes. The most widely used systems of predictive text are Tegic's T9, Motorola's iTap, and the Eatoni Ergonomics' LetterWise and WordWise. T9 and iTap use dictionaries, but Eatoni Ergonomics' products use a disambiguation process, a set of statistical rules to recreate words from keystroke sequences. All predictive text systems require a linguistic database for every supported input language. == Dictionary vs. non-dictionary systems == Traditional disambiguation works by referencing a dictionary of commonly used words, though Eatoni offers a dictionaryless disambiguation system. In dictionary-based systems, as the user presses the number buttons, an algorithm searches the dictionary for a list of possible words that match the keypress combination and offers up the most probable choice. The user can then confirm the selection and move on, or use a key to cycle through the possible combinations. A non-dictionary system constructs words and other sequences of letters from the statistics of word parts. To attempt predictions of the intended result of keystrokes not yet entered, disambiguation may be combined with a word completion facility. Either system (disambiguation or predictive) may include a user database, which can be further classified as a "learning" system when words or phrases are entered into the user database without direct user intervention. The user database is for storing words or phrases that are not well disambiguated by the pre-supplied database. Some disambiguation systems further attempt to correct spelling, format text or perform other automatic rewrites, with the risky effect of either enhancing or frustrating user efforts to enter text. == History == The predictive text and autocomplete technology was invented out of necessities by Chinese scientists and linguists in the 1950s to solve the input inefficiency of the Chinese typewriter, as the typing process involved finding and selecting thousands of logographic characters on a tray, drastically slowing down the word processing speed. The actuating keys of the Chinese typewriter created by Lin Yutang in the 1940s included suggestions for the characters following the one selected. In 1951, the Chinese typesetter Zhang Jiying arranged Chinese characters in associative clusters, a precursor of modern predictive text entry, and broke speed records by doing so. Predictive entry of text from a telephone keypad has been known at least since the 1970s (Smith and Goodwin, 1971). Predictive text was mainly used to look up names in directories over the phone until mobile phone text messaging came into widespread use. == Example == On a typical phone keypad, if users wished to type the in a "multi-tap" keypad entry system, they would need to: Press 8 (tuv) once to select t. Press 4 (ghi) twice to select h. Press 3 (def) twice to select e. Meanwhile, in a phone with predictive text, they need only: Press 8 once to select the (tuv) group for the first character. Press 4 once to select the (ghi) group for the second character. Press 3 once to select the (def) group for the third character. The system updates the display as each keypress is entered, to show the most probable entry. In this example, prediction reduced the number of button presses from five to three. The effect is even greater with longer words and those composed of letters later in each key's sequence. A dictionary-based predictive system is based on the hope that the desired word is in the dictionary. That hope may be misplaced if the word differs in any way from common usage—in particular, if the word is not spelled or typed correctly, is slang, or is a proper noun. In these cases, some other mechanism must be used to enter the word. Furthermore, the simple dictionary approach fails with agglutinative languages, where a single word does not necessarily represent a single semantic entity. == Companies and products == Predictive text is developed and marketed in a variety of competing products, such as Nuance Communications's T9. Other products include Motorola's iTap; Eatoni Ergonomic's LetterWise (character, rather than word-based prediction); WordWise (word-based prediction without a dictionary); EQ3 (a QWERTY-like layout compatible with regular telephone keypads); Prevalent Devices's Phraze-It; Xrgomics' TenGO (a six-key reduced QWERTY keyboard system); Adaptxt (considers language, context, grammar and semantics); Lightkey (a predictive typing software for Windows); Clevertexting (statistical nature of the language, dictionaryless, dynamic key allocation); and Oizea Type (temporal ambiguity); Intelab's Tauto; WordLogic's Intelligent Input Platform™ (patented, layer-based advanced text prediction, includes multi-language dictionary, spell-check, built-in Web search); Google's Gboard. == Textonyms == Words produced by the same combination of keypresses have been called "textonyms"; also "txtonyms"; or "T9o
Social History and Industrial Classification
Social History and Industrial Classification (SHIC) is a classification system used by many British museums for social history and industrial collections. It was first published in 1983. == Purpose == SHIC classifies materials (books, objects, recordings etc.) by their interaction with the people who used them. For example, a carpenter's hammer is classified with other tools of the carpenter, and not with a blacksmith's hammer. In contrast other classification systems, for example the Dewey Decimal Classification, might class all hammers together and close to the classification for other percussive tools. The specialist subject network, Social History Curator's Group (SHCG), obtained funding in 2012 to develop an on-line version, now on their website http://www.shcg.org.uk/ == Scheme == Materials are classified under four major category numbers: Community life Domestic and family life Personal life Working life Further classification within a category is by the use of further numbers after the decimal point. It is permissible to assign more than one classification in cases where the object had more than one use.
AlphaZero
AlphaZero is a computer program developed by artificial intelligence research company DeepMind to master the games of chess, shogi and go. This algorithm uses an approach similar to AlphaGo Zero. On December 5, 2017, the DeepMind team released a preprint paper introducing AlphaZero, which would soon play three games by defeating world-champion chess engines Stockfish, Elmo, and the three-day version of AlphaGo Zero. In each case it made use of custom tensor processing units (TPUs) that the Google programs were optimized to use. AlphaZero was trained solely via self-play using 5,000 first-generation TPUs to generate the games and 64 second-generation TPUs to train the neural networks, all in parallel, with no access to opening books or endgame tables. After four hours of training, DeepMind estimated AlphaZero was playing chess at a higher Elo rating than Stockfish 8; after nine hours of training, the algorithm defeated Stockfish 8 in a time-controlled 100-game tournament (28 wins, 0 losses, and 72 draws). The trained algorithm played on a single machine with four TPUs. DeepMind's paper on AlphaZero was published in the journal Science on 7 December 2018. While the actual AlphaZero program has not been released to the public, the algorithm described in the paper has been implemented in publicly available software. In 2019, DeepMind published a new paper detailing MuZero, a new algorithm able to generalize AlphaZero's work, playing both Atari and board games without knowledge of the rules or representations of the game. == Relation to AlphaGo Zero == AlphaZero (AZ) is a more generalized variant of the AlphaGo Zero (AGZ) algorithm, and is able to play shogi and chess as well as Go. Differences between AZ and AGZ include: AZ has hard-coded rules for setting search hyperparameters. The neural network is now updated continually. AZ doesn't use symmetries, unlike AGZ. Chess or Shogi can end in a draw unlike Go; therefore, AlphaZero takes into account the possibility of a drawn game. == Stockfish and Elmo == Comparing Monte Carlo tree search searches, AlphaZero searches just 80,000 positions per second in chess and 40,000 in shogi, compared to 70 million for Stockfish and 35 million for Elmo. AlphaZero compensates for the lower number of evaluations by using its deep neural network to focus much more selectively on the most promising variation. == Training == AlphaZero was trained by simply playing against itself multiple times, using 5,000 first-generation TPUs to generate the games and 64 second-generation TPUs to train the neural networks. In parallel, the in-training AlphaZero was periodically matched against its benchmark (Stockfish, Elmo, or AlphaGo Zero) in brief one-second-per-move games to determine how well the training was progressing. DeepMind judged that AlphaZero's performance exceeded the benchmark after around four hours of training for Stockfish, two hours for Elmo, and eight hours for AlphaGo Zero. == Preliminary results == === Outcome === ==== Chess ==== In AlphaZero's chess match against Stockfish 8 (2016 TCEC world champion), each program was given one minute per move. AlphaZero was flying the English flag, while Stockfish the Norwegian. Stockfish was allocated 64 threads and a hash size of 1 GB, a setting that Stockfish's Tord Romstad later criticized as suboptimal. AlphaZero was trained on chess for a total of nine hours before the match. During the match, AlphaZero ran on a single machine with four application-specific TPUs. In 100 games from the normal starting position, AlphaZero won 25 games as White, won 3 as Black, and drew the remaining 72. In a series of twelve, 100-game matches (of unspecified time or resource constraints) against Stockfish starting from the 12 most popular human openings, AlphaZero won 290, drew 886 and lost 24. ==== Shogi ==== AlphaZero was trained on shogi for a total of two hours before the tournament. In 100 shogi games against Elmo (World Computer Shogi Championship 27 summer 2017 tournament version with YaneuraOu 4.73 search), AlphaZero won 90 times, lost 8 times and drew twice. As in the chess games, each program got one minute per move, and Elmo was given 64 threads and a hash size of 1 GB. ==== Go ==== After 34 hours of self-learning of Go and against AlphaGo Zero, AlphaZero won 60 games and lost 40. === Analysis === DeepMind stated in its preprint, "The game of chess represented the pinnacle of AI research over several decades. State-of-the-art programs are based on powerful engines that search many millions of positions, leveraging handcrafted domain expertise and sophisticated domain adaptations. AlphaZero is a generic reinforcement learning algorithm – originally devised for the game of go – that achieved superior results within a few hours, searching a thousand times fewer positions, given no domain knowledge except the rules." DeepMind's Demis Hassabis, a chess player himself, called AlphaZero's play style "alien": It sometimes wins by offering counterintuitive sacrifices, like offering up a queen and bishop to exploit a positional advantage. "It's like chess from another dimension." Given the difficulty in chess of forcing a win against a strong opponent, the +28 –0 =72 result is a significant margin of victory. However, some grandmasters, such as Hikaru Nakamura and Komodo developer Larry Kaufman, downplayed AlphaZero's victory, arguing that the match would have been closer if the programs had access to an opening database (since Stockfish was optimized for that scenario). Romstad additionally pointed out that Stockfish is not optimized for rigidly fixed-time moves and the version used was a year old. Similarly, some shogi observers argued that the Elmo hash size was too low, that the resignation settings and the "EnteringKingRule" settings (cf. shogi § Entering King) may have been inappropriate, and that Elmo is already obsolete compared with newer programs. === Reaction and criticism === Papers headlined that the chess training took only four hours: "It was managed in little more than the time between breakfast and lunch." Wired described AlphaZero as "the first multi-skilled AI board-game champ". AI expert Joanna Bryson noted that Google's "knack for good publicity" was putting it in a strong position against challengers. "It's not only about hiring the best programmers. It's also very political, as it helps make Google as strong as possible when negotiating with governments and regulators looking at the AI sector." Human chess grandmasters generally expressed excitement about AlphaZero. Danish grandmaster Peter Heine Nielsen likened AlphaZero's play to that of a superior alien species. Norwegian grandmaster Jon Ludvig Hammer characterized AlphaZero's play as "insane attacking chess" with profound positional understanding. Former champion Garry Kasparov said, "It's a remarkable achievement, even if we should have expected it after AlphaGo." Grandmaster Hikaru Nakamura was less impressed, stating: "I don't necessarily put a lot of credibility in the results simply because my understanding is that AlphaZero is basically using the Google supercomputer and Stockfish doesn't run on that hardware; Stockfish was basically running on what would be my laptop. If you wanna have a match that's comparable you have to have Stockfish running on a supercomputer as well." Top US correspondence chess player Wolff Morrow was also unimpressed, claiming that AlphaZero would probably not make the semifinals of a fair competition such as TCEC where all engines play on equal hardware. Morrow further stated that although he might not be able to beat AlphaZero if AlphaZero played drawish openings such as the Petroff Defence, AlphaZero would not be able to beat him in a correspondence chess game either. Motohiro Isozaki, the author of YaneuraOu, noted that although AlphaZero did comprehensively beat Elmo, the rating of AlphaZero in shogi stopped growing at a point which is at most 100–200 higher than Elmo. This gap is not that high, and Elmo and other shogi software should be able to catch up in 1–2 years. == Final results == DeepMind addressed many of the criticisms in their final version of the paper, published in December 2018 in Science. They further clarified that AlphaZero was not running on a supercomputer; it was trained using 5,000 tensor processing units (TPUs), but only ran on four TPUs and a 44-core CPU in its matches. === Chess === In the final results, Stockfish 9 dev ran under the same conditions as in the TCEC superfinal: 44 CPU cores, Syzygy endgame tablebases, and a 32 GB hash size. Instead of a fixed time control of one move per minute, both engines were given 3 hours plus 15 seconds per move to finish the game. AlphaZero ran on a much more powerful machine with four TPUs in addition to 44 CPU cores. In a 1000-game match, AlphaZero won with a score of 155 wins, 6 losses, and 839 draws. DeepMind also played a series of games using the TCEC opening positions; AlphaZero also won
InRule Technology
InRule Technology is a software company that offers Business Rule Management System (BRMS) enterprise software products. == History == InRule Technology's Chief Executive Officer Rik Chomko and Chief Technology Officer Loren Goodman founded InRule Technology in Chicago in 2002. Paul Hessinger joined InRule Technology in 2004 as chief executive officer and chairman of the board and served until his retirement in 2015. They work with companies in several markets, including financial services, public sector, healthcare, and insurance. In 2007, InRule Technology became a charter member of the Microsoft Business Process Alliance. In August 2019, InRule was acquired by Open Gate Capital. == Products == On October 29, 2012, InRule Technology launched InRule for Microsoft Dynamics CRM. The program provides components to enable creation and update of rules within Microsoft Dynamics CRM, InRule for Microsoft Dynamics CRM provides a platform for shops that prefer to work with Microsoft's platforms. With the availability of InRule 4.6 in 2014, the company introduced deployment of InRule through REST services and allowed REST services to be called from InRule. This enables access to data exposed as a REST service and to package up a rule service for RESTful access. The product launch reflected the move of the company's core audience to use a broader array of technologies despite an earlier focus on .NET. In 2017, InRule introduced InRule for the Salesforce Platform, as well as a technology partnership with Work-Relay, a Business Process Management (BPM) application built on the Salesforce Platform. One year earlier the company introduced InRule for JavaScript, allowing enterprises to run rules on the client-side, server-side or both. The software architecture includes multiple components, including irAuthor, the primary authoring tool for creating and maintaining rules; irVerify, a real-time test environment to run and debug rule applications; and irSDK, a set of APIs that allows developers to integrate inRule into their applications. Additionally, irSOA allows users to access the InRule rule engine as a service. irSOA is now called the irServer Execution Service.
Echo Lake (software)
Echo Lake (AKA Family Album Creator) was the most notable multimedia software product produced by Delrina, which debuted in June 1995. It was touted internally as a "cross [of] Quark Xpress and Myst". It featured an immersive 3D environment where a user could go to a virtual desktop in a virtual office and assemble video and audio clips along with images, and then print them out as either a virtual book other users of the program could use, or for print. It was a highly innovative product for its time, and ultimately was hampered by the inability of many users able to input their own multimedia content easily into a computer from that period. Creative Wonders bought the rights to the Echo Lake multimedia product, which was re-shaped as an introductory program on multimedia and re-released as Family Album Creator in 1996.
Semantic knowledge management
In computer science, semantic knowledge management is a set of practices that seeks to classify content so that the knowledge it contains may be immediately accessed and transformed for delivery to the desired audience, in the required format. This classification of content is semantic in its nature – identifying content by its type or meaning within the content itself and via external, descriptive metadata – and is achieved by employing XML technologies. The specific outcomes of these practices are: Maintain content for multiple audiences together in a single document Transform content into various delivery formats without re-authoring Search for content more effectively Involve more subject-matter experts in the creation of content without reducing quality Reduce production costs for delivery formats Reduce the manual administration of getting the right knowledge to the right people Reduce the cost and time to localize content == Notable semantic knowledge management systems == Learn eXact Thinking Cap LCMS Thinking Cap LMS Xyleme LCMS iMapping