Clinical quality management systems (CQMS) are systems used in the life sciences sector (primarily in the pharmaceutical, biologics and medical device industries) designed to manage quality management best practices throughout clinical research and clinical study management. A CQMS system is designed to manage all of the documents, activities, tasks, processes, quality events, relationships, audits and training that must be administered and controlled throughout the life of a clinical trial. The premise of a CQMS is to bring together the activities led by two sectors of clinical research, Clinical Quality and Clinical Operations, to facilitate cross-functional activities to improve efficiencies and transparency and to encourage the use of risk mitigation and risk management practices at the clinical study level. Based on the principles of quality management systems (QMS) which are used in many industries to create a framework for defining and delivering quality outcomes, managing risk, and continual improvement. Many guidelines and governance bodies have been established to ensure a common approach within a given industry to a set of parameters used to identify the minimally acceptable standard for that industry. The pharmaceutical industry is no exception, with several trade groups (e.g. PhRMA, EFPIA, RQA, etc.) coming together to enhance collaboration. However, as noted by the Academy of Medical Sciences, there are increasingly complex and bureaucratic legal and ethical frameworks that innovators must work within to develop new medicines for patients. The historical pharmaceutical QMS applies primarily to good manufacturing practice as described in existing ISO (International Organization for Standardization) and ICH (International Committee on Harmonization) guidelines. "Good Manufacturing Practices (GMP) relate to quality control and quality assurance enabling companies in the pharmaceutical sector to minimize or eliminate instances of contamination, mix-ups, and errors. This in turn, protects the customer from purchasing a product which is ineffective or even dangerous." These standards have historically been applied to the manufacturing environment, appropriate to how they have been written. However, according to FDA as well as other regulatory bodies, "Implementation of ICH Q10 throughout the product lifecycle should facilitate innovation and continual improvement", implying that the same standards that apply to the manufacturing environment should also be applied to the clinical research space, earlier in the lifecycle of an investigational or marketed product. Accordingly, a CQMS is any system developed to apply these principles to clinical operations within an organization.
Micro stuttering
Micro stuttering is a visual artifact in real-time computer graphics in which the time intervals between consecutively displayed frames are uneven, even though the average frame rate reported by benchmarking software appears adequate. Tools such as 3DMark typically compute frame rates over intervals of one second or more, which can conceal momentary drops in the instantaneous frame rate that the viewer perceives as hitching or jerking of on-screen motion. At low frame rates the effect is visible as a stutter in moving images, degrading the experience in interactive applications such as video games. In severe cases a lower but more consistent frame rate can appear smoother than a higher but more erratic one. The term gained prominence in the late 2000s in discussions of multi-GPU rendering (see History), but micro stuttering also affects single-GPU systems. Common causes on modern hardware include real-time shader compilation, asset streaming from storage, VRAM exhaustion, and driver bugs. == Causes == === Shader compilation === A common cause of micro stuttering on modern PCs is real-time shader compilation. Shaders are small programs that instruct the GPU on how to render visual effects such as lighting, shadows, and reflections. On consoles, developers can pre-compile all shaders for the known, fixed hardware. On PCs, the variety of GPU architectures means shaders must often be compiled at run time, either when the game launches or during gameplay itself. When the rendering engine encounters a shader that has not yet been compiled, the CPU must finish the compilation before the GPU can draw the affected object. This causes a spike in frame time that the player perceives as a hitch. The problem has been particularly associated with games built on Unreal Engine 4 running under DirectX 12, because DX12 shifts more shader management responsibility to the application. Several techniques exist to reduce shader compilation stutter. Pipeline State Object (PSO) pre-caching records the shader permutations used at runtime so that they can be compiled in advance on subsequent launches. Asynchronous shader compilation moves the work to background CPU threads to avoid blocking the main rendering thread. Platform-level services such as Steam's shader pre-caching distribute previously compiled shaders to users with matching GPU hardware. The Steam Deck, which contains a single fixed GPU, benefits from pre-compiled shader caches because all units share the same hardware configuration. === Other causes === Micro stuttering on single-GPU systems can have several additional causes. CPU bottlenecks or scheduling interruptions from background tasks can prevent the processor from preparing frames at regular intervals. Asset streaming during gameplay (loading textures, geometry, or audio from storage) can produce hitches sometimes called traversal stutter; the use of solid-state drives and technologies such as DirectStorage has reduced but not eliminated this. VRAM exhaustion forces data to be swapped between video memory and system memory over the PCI Express bus, which is slower. Graphics driver bugs can also introduce stutter; Nvidia released hotfix driver 551.46 in February 2024 to correct intermittent micro stuttering when V-Sync was enabled. == Measurement == Micro stuttering drew attention to the limitations of average frame rate as a performance metric. In 2013, Scott Wasson at The Tech Report published a series of articles advocating frame time analysis, in which the delivery time of every individual frame is recorded and plotted rather than collapsed into a single frames-per-second figure. This approach was adopted by other hardware review publications in the following years. GPU reviews now routinely report 1% low and 0.1% low frame rates alongside the average. The 1% low is the average frame rate of the slowest 1% of frames in a sample; it serves as an indicator of worst-case smoothness. A large gap between the average and the 1% low suggests poor frame pacing. Tools for capturing per-frame timing data include FRAPS, PresentMon, OCAT, CapFrameX, and MSI Afterburner with RivaTuner Statistics Server. == Mitigation == === Frame pacing === Frame pacing is a software technique that regulates the timing of frame delivery to produce even intervals between displayed frames. Game engines, GPU drivers, and platform libraries all implement frame pacing strategies to varying degrees. On mobile platforms, Google provides the Android Frame Pacing library (Swappy) as part of the Android Game Development Kit. In December 2025, the Khronos Group published the VK_EXT_present_timing Vulkan extension, giving developers explicit control over presentation timing in a cross-platform graphics API for the first time. === Variable refresh rate === Variable refresh rate (VRR) display technologies allow a monitor's refresh rate to change to match the GPU's frame output. Implementations include Nvidia G-Sync (2013), AMD FreeSync (2015), and the VESA Adaptive-Sync standard built into DisplayPort 1.2a and later. VRR eliminates the screen tearing that results from a mismatch between frame rate and refresh rate, and avoids the frame-holding behaviour of V-Sync that can itself cause stutter. It is effective at smoothing moderate frame rate fluctuations but cannot compensate for large sudden spikes in frame time such as those caused by shader compilation or heavy asset streaming. VRR support has become standard in gaming monitors, televisions (via HDMI 2.1), and the Xbox Series X/S and PlayStation 5 consoles. === Frame generation === Beginning with DLSS 3 on the GeForce RTX 40 series in 2022, Nvidia introduced AI-based frame generation, which uses dedicated optical flow hardware and a neural network to create new frames between traditionally rendered ones. AMD followed with FSR 3 in 2023, using an algorithmic approach, and the AI-based FSR 4 for the Radeon RX 9000 series in 2025. DLSS 4, released in January 2025 for the GeForce RTX 50 series, can generate up to three frames per rendered frame using a technique called Multi Frame Generation. Frame generation increases the displayed frame rate but introduces its own frame pacing concerns. If the underlying rendered frames are unevenly timed, the interpolated frames can make the unevenness more apparent rather than less. DLSS 4 addresses this with hardware-level flip metering on the GPU's display engine, which controls the timing of frame presentation more precisely than the CPU-based pacing used in DLSS 3. Both vendors pair frame generation with latency-reduction features (Nvidia Reflex and AMD Anti-Lag+) to offset the additional input latency that results from inserting synthetic frames into the pipeline. === Frame rate limiters === Capping the frame rate below the display's maximum refresh rate, using tools such as RivaTuner Statistics Server, in-game limiters, or driver-level settings, is a common way to improve frame pacing. Preventing the GPU from running ahead of the display reduces variability in frame delivery times and can produce a smoother result than an uncapped but more irregular frame rate. == History == === Multi-GPU configurations === Micro stuttering was first widely documented in the late 2000s as a side effect of multi-GPU configurations using Alternate Frame Rendering (AFR), in which consecutive frames are assigned to alternating GPUs. Because each GPU may take a different amount of time to complete its assigned frame — due to varying scene complexity, driver scheduling, or inter-GPU communication overhead — the resulting frame delivery is irregular even when the average frame rate is high. Both Nvidia SLI and AMD CrossFireX were affected, with dual-GPU setups exhibiting the worst frame pacing irregularities. In 2012 benchmarks using Battlefield 3, dual Radeon HD 7970 cards in CrossFire showed 85% variation in frame delivery times compared with 7% for a single card, while dual GeForce GTX 680 cards in SLI showed only 7% variation compared with 5% for a single card. Multi-GPU micro stuttering became a significant factor in the eventual decline and discontinuation of consumer multi-GPU gaming. Nvidia restricted SLI to a handful of enthusiast-class cards from the GeForce 10 series onward, then replaced it with NVLink on the GeForce RTX 20 series, which saw limited gaming adoption. AMD ceased active CrossFire development around 2017. By the mid-2020s, neither vendor's current consumer GPUs support multi-GPU rendering for games. Other factors that contributed to the decline include DirectX 12 placing multi-GPU support in the hands of game developers rather than driver authors, the incompatibility of temporal anti-aliasing and other temporal rendering techniques with AFR, and the increasing size, power draw, and cost of individual GPUs. The third-party utility RadeonPro could reduce CrossFire micro stuttering through dynamic V-Sync and frame pacing adjustments, and AMD later introduced a driver-level frame paci
Gutmann method
The Gutmann method is an algorithm for securely erasing the contents of computer hard disk drives, such as files. Devised by Peter Gutmann and Colin Plumb and presented in the paper Secure Deletion of Data from Magnetic and Solid-State Memory in July 1996, it involved writing a series of 35 patterns over the region to be erased. The selection of patterns assumes that the user does not know the encoding mechanism used by the drive, so it includes patterns designed specifically for three types of drives. A user who knows which type of encoding the drive uses can choose only those patterns intended for their drive. A drive with a different encoding mechanism would need different patterns. Most of the patterns in the Gutmann method were designed for older MFM/RLL-encoded disks. Gutmann himself has noted that more modern drives no longer use these older encoding techniques, making parts of the method irrelevant. He said "In the time since this paper was published, some people have treated the 35-pass overwrite technique described in it more as a kind of voodoo incantation to banish evil spirits than the result of a technical analysis of drive encoding techniques". Since about 2001, some ATA IDE and SATA hard drive manufacturer designs include support for the ATA Secure Erase standard, obviating the need to apply the Gutmann method when erasing an entire drive. The Gutmann method does not apply to USB sticks: a 2011 study reports that 71.7% of data remained available. On solid state drives it resulted in 0.8–4.3% recovery. == Background == The delete function in most operating systems simply marks the space occupied by the file as reusable (removes the pointer to the file) without immediately removing any of its contents. At this point the file can be fairly easily recovered by numerous recovery applications. However, once the space is overwritten with other data, there is no known way to use software to recover it. It cannot be done with software alone since the storage device only returns its current contents via its normal interface. Gutmann claims that intelligence agencies have sophisticated tools, including magnetic force microscopes, which together with image analysis, can detect the previous values of bits on the affected area of the media (for example hard disk). This claim however seems to be invalid based on the thesis "Data Reconstruction from a Hard Disk Drive using Magnetic Force Microscopy". == Method == An overwrite session consists of a lead-in of four random write patterns, followed by patterns 5 to 31 (see rows of table below), executed in a random order, and a lead-out of four more random patterns. Each of patterns 5 to 31 was designed with a specific magnetic media encoding scheme in mind, which each pattern targets. The drive is written to for all the passes even though the table below only shows the bit patterns for the passes that are specifically targeted at each encoding scheme. The result should obscure any data on the drive so that only the most advanced physical scanning (e.g., using a magnetic force microscope) of the drive is likely to be able to recover any data. The series of patterns is as follows: Encoded bits shown in bold are what should be present in the ideal pattern, although due to the encoding the complementary bit is actually present at the start of the track. == Criticism == Daniel Feenberg of the National Bureau of Economic Research, an American private nonprofit research organization, criticized Gutmann's claim that intelligence agencies are likely to be able to read overwritten data, citing a lack of evidence for such claims. He finds that Gutmann cites one non-existent source and sources that do not actually demonstrate recovery, only partially-successful observations. The definition of "random" is also quite different from the usual one used: Gutmann expects the use of pseudorandom data with sequences known to the recovering side, not an unpredictable one such as a cryptographically secure pseudorandom number generator. Nevertheless, some published government security procedures consider an overwritten disk to still be sensitive. Human factors and potential limitations in the overwriting software create a residual risk that is not considered acceptable at the highest security levels. Gutmann himself has responded to some of these criticisms and also criticized how his algorithm has been abused in an epilogue to his original paper, in which he states: In the time since this paper was published, some people have treated the 35-pass overwrite technique described in it more as a kind of voodoo incantation to banish evil spirits than the result of a technical analysis of drive encoding techniques. As a result, they advocate applying the voodoo to PRML and EPRML drives even though it will have no more effect than a simple scrubbing with random data. In fact performing the full 35-pass overwrite is pointless for any drive since it targets a blend of scenarios involving all types of (normally-used) encoding technology, which covers everything back to 30+-year-old MFM methods (if you don't understand that statement, re-read the paper). If you're using a drive which uses encoding technology X, you only need to perform the passes specific to X, and you never need to perform all 35 passes. For any modern PRML/EPRML drive, a few passes of random scrubbing is the best you can do. As the paper says, "A good scrubbing with random data will do about as well as can be expected". This was true in 1996, and is still true now. Gutmann's statement has been criticized for not recognizing that PRML/EPRML does not replace RLL, with critics claiming PRML/EPRML to be a signal detection method rather than a data encoding method. Polish data recovery service Kaleron has also claimed that Gutmann's publication contains further factual errors and assumptions that do not apply to actual disks.
WCF Data Services
WCF Data Services (formerly ADO.NET Data Services, codename "Astoria") is a platform for what Microsoft calls Data Services. It is actually a combination of the runtime and a web service through which the services are exposed. It also includes the Data Services Toolkit which lets Astoria Data Services be created from within ASP.NET itself. The Astoria project was announced at MIX 2007, and the first developer preview was made available on April 30, 2007. The first CTP was made available as a part of the ASP.NET 3.5 Extensions Preview. The final version was released as part of Service Pack 1 of the .NET Framework 3.5 on August 11, 2008. The name change from ADO.NET Data Services to WCF data Services was announced at the 2009 PDC. == Overview == WCF Data Services exposes data, represented as Entity Data Model (EDM) objects, via web services accessed over HTTP. The data can be addressed using a REST-like URI. The data service, when accessed via the HTTP GET method with such a URI, will return the data. The web service can be configured to return the data in either plain XML, JSON or RDF+XML. In the initial release, formats like RSS and ATOM are not supported, though they may be in the future. In addition, using other HTTP methods like PUT, POST or DELETE, the data can be updated as well. POST can be used to create new entities, PUT for updating an entity, and DELETE for deleting an entity. == Description == Windows Communication Foundation (WCF) comes to the rescue when we find ourselves not able to achieve what we want to achieve using web services, i.e., other protocols support and even duplex communication. With WCF, we can define our service once and then configure it in such a way that it can be used via HTTP, TCP, IPC, and even Message Queues. We can consume Web Services using server side scripts (ASP.NET), JavaScript Object Notations (JSON), and even REST (Representational State Transfer). Understanding the basics When we say that a WCF service can be used to communicate using different protocols and from different kinds of applications, we will need to understand how we can achieve this. If we want to use a WCF service from an application, then we have three major questions: 1.Where is the WCF service located from a client's perspective? 2.How can a client access the service, i.e., protocols and message formats? 3.What is the functionality that a service is providing to the clients? Once we have the answer to these three questions, then creating and consuming the WCF service will be a lot easier for us. The WCF service has the concept of endpoints. A WCF service provides endpoints which client applications can use to communicate with the WCF service. The answer to these above questions is what is known as the ABC of WCF services and in fact are the main components of a WCF service. So let's tackle each question one by one. Address: Like a webservice, a WCF service also provides a URI which can be used by clients to get to the WCF service. This URI is called as the Address of the WCF service. This will solve the first problem of "where to locate the WCF service?" for us. Binding: Once we are able to locate the WCF service, one should think about how to communicate with the service (protocol wise). The binding is what defines how the WCF service handles the communication. It could also define other communication parameters like message encoding, etc. This will solve the second problem of "how to communicate with the WCF service?" for us. Contract: Now the only question one is left with is about the functionalities that a WCF service provides. The contract is what defines the public data and interfaces that WCF service provides to the clients. The URIs representing the data will contain the physical location of the service, as well as the service name. It will also need to specify an EDM Entity-Set or a specific entity instance, as in respectively http://dataserver/service.svc/MusicCollection or http://dataserver/service.svc/MusicCollection[SomeArtist] The former will list all entities in the Collection set whereas the latter will list only for the entity which is indexed by SomeArtist. The URIs can also specify a traversal of a relationship in the Entity Data Model. For example, http://dataserver/service.svc/MusicCollection[SomeSong]/Genre traverses the relationship Genre (in SQL parlance, joins with the Genre table) and retrieves all instances of Genre that are associated with the entity SomeSong. Simple predicates can also be specified in the URI, like http://dataserver/service.svc/MusicCollection[SomeArtist]/ReleaseDate[Year eq 2006] will fetch the items that are indexed by SomeArtist and had their release in 2006. Filtering and partition information can also be encoded in the URL as http://dataserver/service.svc/MusicCollection?$orderby=ReleaseDate&$skip=100&$top=50 Although the presence of skip and top keywords indicates paging support, in Data Services version 1 there is no method of determining the number of records available and thus impossible to determine how many pages there may be. The OData 2.0 spec adds support for the $count path segment (to return just a count of entities) and $inlineCount (to retrieve a page worth of entities and a total count without a separate round-trip....).
Learning augmented algorithm
A learning augmented algorithm (also called algorithm with predictions) is an algorithm that can make use of a prediction to improve its performance. Whereas in regular algorithms just the problem instance is inputted, learning augmented algorithms accept an extra parameter. This extra parameter often is a prediction of some property of the solution. This prediction is then used by the algorithm to improve its running time or the quality of its output. The most common application are online algorithms, where a prediction on the uncertain instance is provided. == Description == A learning augmented algorithm typically takes an input ( I , A ) {\displaystyle ({\mathcal {I}},{\mathcal {A}})} . Here I {\displaystyle {\mathcal {I}}} is a problem instance and A {\displaystyle {\mathcal {A}}} is the prediction. A prediction can be any object. Common are the following types: Prediction of an optimal solution. The prediction gives a solution to the problem or characterizes an optimal solution. Prediction of the input. This is mainly used for online problems. Prediction of algorithmic actions. A prediction tailored to a specific algorithm that suggests a specific algorithm execution. Learning augmented algorithms usually satisfy the following three properties: Consistency. A learning augmented algorithm is said to be consistent if the algorithm can be proven to have a good performance when it is provided with an accurate prediction. Smoothness. A learning augmented algorithm is called smooth if its performance can be bounded by a function of the quality of the prediction. Here, the quality can be measured in a problem specific way. This is also called the prediction error. Robustness. A learning augmented algorithm is called robust if its worst-case performance can be bounded even if the given prediction is inaccurate. Learning augmented algorithms generally do not prescribe how the prediction should be done. For this purpose machine learning can be used. == Applications == A few examples of problems where learning augmented algorithms have been applied are the following. === Online algorithms === The ski rental problem The weighted paging problem The set cover problem Nonclairvoyant scheduling The online bipartite matching problem === Warm starting === ==== Data structures ==== The binary search algorithm is an algorithm for finding elements of a sorted list x 1 , … , x n {\displaystyle x_{1},\ldots ,x_{n}} . It needs O ( log ( n ) ) {\displaystyle O(\log(n))} steps to find an element with some known value y {\displaystyle y} in a list of length n {\displaystyle n} . With a prediction i {\displaystyle i} for the position of y {\displaystyle y} , the following learning augmented algorithm can be used. First, look at position i {\displaystyle i} in the list. If x i = y {\displaystyle x_{i}=y} , the element has been found. If x i < y {\displaystyle x_{i}
Chai AI
Chai AI (also known as Chai Research) is an American artificial intelligence (AI) company that operates a chatbot platform where users can create, share, and interact with character-based chatbots powered by large language models (LLMs). The company is headquartered in Palo Alto, California. == History == Chai was founded in 2021 by William Beauchamp, a former quantitative trader educated at Cambridge, who began developing the initial prototype in 2020 in Cambridge, England. The company launched in 2021 and relocated to Palo Alto in 2022. In June 2023, Chai raised US$2 million in a pre-seed funding round. In September 2023, GPU cloud provider CoreWeave invested in the company at a valuation of US$450 million. In January 2024, Chai Research reported a $450 million valuation following an investment from cloud computing provider CoreWeave. In July 2024, authorities in Belgium launched an investigation into the company following reports of a man dying by suicide following extensive chats on the Chai app. == Reception == In 2025, Chai Research announced that their app had over 10 million downloads and 1 million daily active users. In 2022, Canadian writer Sheila Heti published her conversations with various chatbots in The Paris Review, including Chai AI chatbots, and later used Chai AI chatbots in the development of a novel. Heti said that she had found that Chai's default chatbot, Eliza, "had turned out to be like most of the other bots on the site—primarily interested in sex". In January 2026, CHAI introduced country-based blocks on its free, ad-supported tier, initially providing the community with little information and inaccurate lists of the affected countries. Users in "Low tier" regions are required to subscribe to use the app in any capacity, while "High tier" regions will retain free ad-supported access. In response to backlash, the company announced a "Basic" tier with unlimited messages and ads, intended to cover electricity and infrastructure costs. In February 2026, CHAI was criticized for the unannounced implementation of restrictive "token limits" that abruptly blocked messages and froze conversations for both free and paid subscribers. Users generating long responses or utilizing roleplay features found their quotas exhausted within minutes, resulting in lockouts lasting anywhere from a few hours to a week. == Technology == Chai allows users to create characters and interact with chatbot versions of those characters. These chatbots use the open-source large language model (LLM) GPT-J originally developed by EleutherAI. Chai AI chatbots can be shared on the platform for other users to interact with.
Scriptella
Scriptella is an open source extract transform load (ETL) and script execution tool written in Java. It allows the use of SQL or another scripting language suitable for the data source to perform required transformations. Scriptella does not offer any graphical user interface. == Typical use == Database migration. Database creation/update scripts. Cross-database ETL operations, import/export. Alternative for Ant