Bioelectronics

Bioelectronics

Bioelectronics is a field of research in the convergence of biology and electronics. == Definitions == At the first C.E.C. Workshop, in Brussels in November 1991, bioelectronics was defined as 'the use of biological materials and biological architectures for information processing systems and new devices'. Bioelectronics, specifically bio-molecular electronics, were described as 'the research and development of bio-inspired (i.e. self-assembly) inorganic and organic materials and of bio-inspired (i.e. massive parallelism) hardware architectures for the implementation of new information processing systems, sensors and actuators, and for molecular manufacturing down to the atomic scale'. The National Institute of Standards and Technology (NIST), an agency of the United States Department of Commerce, defined bioelectronics in a 2009 report as "the discipline resulting from the convergence of biology and electronics". Sources for information about the field include the Institute of Electrical and Electronics Engineers (IEEE) with its Elsevier journal Biosensors and Bioelectronics published since 1990. The journal describes the scope of bioelectronics as seeking to : "... exploit biology in conjunction with electronics in a wider context encompassing, for example, biological fuel cells, bionics and biomaterials for information processing, information storage, electronic components and actuators. A key aspect is the interface between biological materials and micro and nano-electronics." == History == The first known study of bioelectronics took place in the 18th century when Italian physician-scientist Luigi Galvani applied a voltage to a pair of detached frog legs. The legs moved, sparking the genesis of bioelectronics. Electronics technology has been applied to biology and medicine since the pacemaker was invented and with the medical imaging industry. In 2009, a survey of publications using the term in title or abstract suggested that the center of activity was in Europe (43 percent), followed by Asia (23 percent) and the United States (20 percent). == Materials == Organic bioelectronics is the application of organic electronic material to the field of bioelectronics. Organic materials (i.e. containing carbon) show great promise when it comes to interfacing with biological systems. Current applications focus around neuroscience and infection. Conducting polymer coatings, an organic electronic material, shows massive improvement in the technology of materials. It was the most sophisticated form of electrical stimulation. It improved the impedance of electrodes in electrical stimulation, resulting in better recordings and reducing "harmful electrochemical side reactions." Organic Electrochemical Transistors (OECT) were invented in 1984 by Mark Wrighton and colleagues, which had the ability to transport ions. This improved signal-to-noise ratio and gives for low measured impedance. The Organic Electronic Ion Pump (OEIP), a device that could be used to target specific body parts and organs to adhere medicine, was created by Magnuss Berggren. As one of the few materials well established in CMOS technology, titanium nitride (TiN) turned out as exceptionally stable and well suited for electrode applications in medical implants. == Significant applications == Bioelectronics is used to help improve the lives of people with disabilities and diseases. For example, the glucose monitor is a portable device that allows diabetic patients to control and measure their blood sugar levels. Electrical stimulation used to treat patients with epilepsy, chronic pain, Parkinson's, deafness, Essential Tremor and blindness. Magnuss Berggren and colleagues created a variation of his OEIP, the first bioelectronic implant device that was used in a living, free animal for therapeutic reasons. It transmitted electric currents into GABA, an acid. A lack of GABA in the body is a factor in chronic pain. GABA would then be dispersed properly to the damaged nerves, acting as a painkiller. Vagus Nerve Stimulation (VNS) is used to activate the Cholinergic Anti-inflammatory Pathway (CAP) in the vagus nerve, ending in reduced inflammation in patients with diseases like arthritis. Since patients with depression and epilepsy are more vulnerable to having a closed CAP, VNS can aid them as well. At the same time, not all the systems that have electronics used to help improving the lives of people are necessarily bioelectronic devices, but only those which involve an intimate and directly interface of electronics and biological systems. Bioelectronics could be used to develop new label-free methods for monitoring cancer cell invasion and drug resistance. For example, the electrical resistance of cancer cells could be used to predict the effectiveness of cancer drugs and to identify drugs that are most likely to be effective against a particular type of cancer. === Human tissue regeneration === Human tissue, like most tissue in multicellular life, is known to be capable of regeneration. While tissue such as skin and even large organs such as the liver have been shown significant capacity for regeneration much of the adult body is thought to possess limited natural regenerative ability. Research in the field of regenerative medicine has identified that developmental bioelectricity can be used to stimulate and modify tissue growth beyond what naturally occurs with efforts to demonstrate its feasibility in mammals underway. Some researchers believe that future advancements could allow for the regeneration of organs or even entire limbs using bioelectronic devices providing the correct signals. == Future == The improvement of standards and tools to monitor the state of cells at subcellular resolutions is lacking funding and employment. This is a problem because advances in other fields of science are beginning to analyze large cell populations, increasing the need for a device that can monitor cells at such a level of sight. Cells cannot be used in many ways other than their main purpose, like detecting harmful substances. Merging this science with forms of nanotechnology could result in incredibly accurate detection methods. The preserving of human lives like protecting against bioterrorism is the biggest area of work being done in bioelectronics. Governments are starting to demand devices and materials that detect chemical and biological threats. The more the size of the devices decrease, there will be an increase in performance and capabilities.

Data cube

In computer programming, a data cube (or datacube) is a multi-dimensional array of values. Typically, the term "data cube" is applied in contexts where these arrays are massively larger than the hosting computer's main memory; examples include multi-terabyte/petabyte data warehouses and time series of image data. Even though it is called a cube, a data cube generally is a multi-dimensional concept which can be 1-dimensional, 2-dimensional, 3-dimensional, or higher-dimensional. The data cube is used to represent data (sometimes called facts) along some dimensions of interest. In satellite image timeseries, dimensions would be latitude and longitude coordinates and time; a fact (sometimes called measure) would be a pixel at a given space and time as taken by the satellite. For example, in online analytical processing, an OLAP cube about a company would have dimensions that could be the company subsidiaries, the company products, and time; in this setup, a fact would be a sales event where a particular product has been sold in a particular subsidiary at a particular time. In any case, every dimension divides data into groups of cells whereas each cell in the cube represents a single measure of interest. Sometimes cubes hold only a few values with the rest being empty, i.e. undefined, while sometimes most or all cube coordinates hold a cell value. In the first case such data are called sparse, and in the second case they are called dense, although there is no hard delineation between the two. Data cubes may be stored in database management systems (DBMS) as part of array DBMS. Spatio-temporal databases and geospatial databases may also be represented as coverage data. == History == Multi-dimensional arrays have long been familiar in programming languages. Fortran offers arbitrarily-indexed 1-D arrays and arrays of arrays, which allows the construction of higher-dimensional arrays, up to 15 dimensions. APL supports n-D arrays with a rich set of operations. All these have in common that arrays must fit into the main memory and are available only while the particular program maintaining them (such as image processing software) is running. A series of data exchange formats support storage and transmission of data cube-like data, often tailored towards particular application domains. Examples include MDX for statistical (in particular, business) data, Zarr and Hierarchical Data Format for general scientific data, and TIFF for imagery. In 1992, Peter Baumann introduced management of massive data cubes with high-level user functionality combined with an efficient software architecture. Datacube operations include subset extraction, processing, fusion, and in general queries in the spirit of data manipulation languages like SQL. Some years after, the data cube concept was applied to describe time-varying business data as data cubes by Jim Gray, et al., and by Venky Harinarayan, Anand Rajaraman and Jeff Ullman. Around that time, a working group on Multi-Dimensional Databases ("Arbeitskreis Multi-Dimensionale Datenbanken") was established at German Gesellschaft für Informatik. Datacube Inc. was an image processing company selling hardware and software applications for the PC market in 1996, however without addressing data cubes as such. The EarthServer initiative has established geo data cube service requirements. == Standardization == In 2018, the ISO SQL database language was extended with data cube functionality as "SQL – Part 15: Multi-dimensional arrays (SQL/MDA)". Web Coverage Processing Service is a geo data cube analytics language issued by the Open Geospatial Consortium in 2008. In addition to the common data cube operations, the language knows about the semantics of space and time and supports both regular and irregular grid data cubes, based on the concept of coverage data. An industry standard for querying business data cubes, originally developed by Microsoft, is MultiDimensional eXpressions. == Implementation == Many high-level computer languages treat data cubes and other large arrays as single entities distinct from their contents. These languages, of which Fortran, APL, IDL, NumPy, PDL, and S-Lang are examples, allow the programmer to manipulate complete film clips and other data en masse with simple expressions derived from linear algebra and vector mathematics. Some languages (such as PDL) distinguish between a list of images and a data cube, while many (such as IDL) do not. Array DBMSs (Database Management Systems) offer a data model which generically supports definition, management, retrieval, and manipulation of n-dimensional data cubes. This database category has been pioneered by the rasdaman system since 1994. == Applications == Multi-dimensional arrays can meaningfully represent spatio-temporal sensor, image, and simulation data, but also statistics data where the semantics of dimensions is not necessarily of spatial or temporal nature. Generally, any kind of axis can be combined with any other into a data cube. === Mathematics === In mathematics, a one-dimensional array corresponds to a vector, a two-dimensional array resembles a matrix; more generally, a tensor may be represented as an n-dimensional data cube. === Science and engineering === For a time sequence of color images, the array is generally four-dimensional, with the dimensions representing image X and Y coordinates, time, and RGB (or other color space) color plane. For example, the EarthServer initiative unites data centers from different continents offering 3-D x/y/t satellite image timeseries and 4-D x/y/z/t weather data for retrieval and server-side processing through the Open Geospatial Consortium WCPS geo data cube query language standard. A data cube is also used in the field of imaging spectroscopy, since a spectrally-resolved image is represented as a three-dimensional volume. Earth observation data cubes combine satellite imagery such as Landsat 8 and Sentinel-2 with Geographic information system analytics. === Business intelligence === In online analytical processing (OLAP), data cubes are a common arrangement of business data suitable for analysis from different perspectives through operations like slicing, dicing, pivoting, and aggregation.

AI Futures Project

The AI Futures Project is a nonprofit research organization based in the United States that specializes in forecasting the development and societal impact of advanced artificial intelligence. The organization is best known for its 2025 scenario forecast, AI 2027, which examines the potential near-term emergence of artificial general intelligence (AGI) and its possible global consequences. == History == The AI Futures Project was founded in 2025 by Daniel Kokotajlo, a former researcher in the governance division of OpenAI. Kokotajlo resigned from OpenAI in April 2024, expressing concerns that the company prioritized rapid product development over AI safety and was advancing without sufficient safeguards. He founded the nonprofit to conduct independent forecasting and policy research. The organization is registered as a 501(c)(3) nonprofit in the United States and is funded through donations. It operates with a small research staff and network of advisors drawn from fields including AI policy, forecasting, and risk analysis. == Activities == The mission of the AI Futures Project is to develop detailed scenario forecasts of the trajectory of advanced AI systems to inform policymakers, researchers, and the public. In addition to written reports, the group has conducted tabletop exercises and workshops based on its scenarios, involving participants from academia, technology, and public policy. == AI 2027 == In April 2025, the AI Futures Project released AI 2027, a detailed scenario forecast describing possible developments in AI between 2025 and 2027. The report was authored by Daniel Kokotajlo along with Eli Lifland, Thomas Larsen, and Romeo Dean, with editing assistance from blogger Scott Alexander. The scenario depicts very rapid progress in AI capabilities, including the development of autonomous AI systems capable of recursive self-improvement. AI 2027 presents two alternative endings: one in which international competition over advanced AI leads to catastrophic loss of human control, and another in which coordinated global action slows down development and averts imminent disaster. The authors emphasize that the narratives are hypothetical and intended as planning tools rather than literal forecasts. == Reception == AI 2027 attracted attention from technology journalists and AI researchers. Some commentators praised the report for its level of detail and its usefulness as a strategic planning exercise, while others criticized the scenario as implausibly aggressive in its timelines. The report was cited in policy discussions about AI governance. U.S. Vice President JD Vance reportedly read AI 2027 and referenced its warnings in conversations about international AI coordination. More recent reporting noted that the authors of AI 2027 had publicly revised some of their timelines. According to Kokotajlo, developments since the report's original publication suggested a slower path toward fully autonomous AI research systems than initially forecasted.

GPT-5.3-Codex

GPT-5.3-Codex (Generative Pre-trained Transformer 5.3 Codex) is a large language model (LLM) announced and released by OpenAI on February 5, 2026. It is made as a competitor to Claude's Opus 4.6, focusing on code generation, speed and the ability to search repositories, run terminal commands and at the same time, debug code. In technical benchmarks, it is reported that GPT-5.3 Codex is 25% faster than Opus 4.6. GPT-5.3 Codex is available in the Codex app and on the web; access via API is also planned. According to OpenAI, GPT-5.3-Codex is the company's "first model that was instrumental in creating itself." On February 12, 2026, GPT-5.3-Codex-Spark was released in a research preview, which is a smaller version of GPT-5.3-Codex which supports text-only input. As of February 2026, GPT-5.3-Codex is only available for ChatGPT Pro ($200/month) subscribers.

Knowledge processing for robots

KnowRob (Knowledge processing for robots) is a system which combines knowledge representation and reasoning methods to acquire and ground knowledge. This system is the backbone of openEASE. both under developing at the Institute for Artificial Intelligence at the University of Bremen, Germany. == The framework == KnowRob can serve as a common sense framework for the integration of knowledge. This knowledge can be static encyclopedic knowledge, common sense knowledge, task descriptions, environment models, object information, observed actions, etc., which can come from different sources, like manually axiomatized, derived from observations, or imported from the web. KnowRob has been used by different research groups, as the Rice University using the ontological knowledge base in a robotic platform. As well by the Eindhoven University of Technology research group competing in the RoboCup league, in the "at Home" category, with the RoboEarth project. As well, KnowRob is mentioned in the work of some research groups from the Lucian Blaga University of Sibiu, Middle East Technical University in their combination of different knowledge bases, Keio University as related work because of the ontology service, University of Texas at Austin as related work as well because of the relation with the work presented, Hanyang University as related work as an OWL based knowledge processing framework. == Representations == To represent the knowledge, KnowRob uses the OWL ontology language and an extended first-order logic knowledge representation with computable predicates. To give the order of subactions, KnowRob includes a pair-wise ordering constrain, which gives a partial ordering. KnowRob adopts the closed-world assumption Prolog, and an open-world assumption by the use of computables. To include reasoning rules into Prolog, KnowRob uses an inference procedure beyond the capabilities of OWL to extract information about tasks executions. In its second version, KnowRob provides a logic interface to the hybrid reasoning kernel as a logic based language. This language presents the hybrid reasoning kernel as if everything were entities retrievable by providing partial descriptions for them. This entities descriptions include objects, their parts, and articulation models, environments composed of objects, software components, actions, and events. === Episodic memories === Episodic memory is related to the experience information, which is organized temporally and spatially, alongside combined with context information. In KnowRob, an episodic memory is understood as a recording that the agent makes of the ongoing activity, which includes very detailed information about the actions, motions, their purposes, effects and the behavior they generate, it also includes the images captured during execution, etc. == Usage == The knowledge is computed by external methods using Prolog queries. In the second version of the KnowRob system, is included a better structure of the packages and documentations. Which includes some extensions from the previous version, as well as a logic based language. For example, a cup description from perception can be represented in this language as: entity(Cup,[an, object, [type, cup], [shape, cylinder], [color, orange]]) As well, a controller could represent the same object as: entity(Cup, [an, object, [type, cup], [proper_physical_parts, [an, object, [type, handle], [grasp−pose, G−pose]]]]) The interface language is comparable to other query languages for symbolic knowledge bases. KnowRob's query language integrates reasoning methods, such as the simulation-based reasoning. == Goals == The goal of the KnowRob framework is to make semantic knowledge available for service robots. It is able to answer queries about missing information in vague instructions for tasks. This is possible with the actions hierarchical representation and information about objects which can be included in certain action.

Reparameterization trick

The reparameterization trick (aka "reparameterization gradient estimator") is a technique used in statistical machine learning, particularly in variational inference, variational autoencoders, and stochastic optimization. It allows for the efficient computation of gradients through random variables, enabling the optimization of parametric probability models using stochastic gradient descent, and the variance reduction of estimators. It was developed in the 1980s in operations research, under the name of "pathwise gradients", or "stochastic gradients". Its use in variational inference was proposed in 2013. == Mathematics == Let z {\displaystyle z} be a random variable with distribution q ϕ ( z ) {\displaystyle q_{\phi }(z)} , where ϕ {\displaystyle \phi } is a vector containing the parameters of the distribution. === REINFORCE estimator === Consider an objective function of the form: L ( ϕ ) = E z ∼ q ϕ ( z ) [ f ( z ) ] {\displaystyle L(\phi )=\mathbb {E} _{z\sim q_{\phi }(z)}[f(z)]} Without the reparameterization trick, estimating the gradient ∇ ϕ L ( ϕ ) {\displaystyle \nabla _{\phi }L(\phi )} can be challenging, because the parameter appears in the random variable itself. In more detail, we have to statistically estimate: ∇ ϕ L ( ϕ ) = ∇ ϕ ∫ d z q ϕ ( z ) f ( z ) {\displaystyle \nabla _{\phi }L(\phi )=\nabla _{\phi }\int dz\;q_{\phi }(z)f(z)} The REINFORCE estimator, widely used in reinforcement learning and especially policy gradient, uses the following equality: ∇ ϕ L ( ϕ ) = ∫ d z q ϕ ( z ) ∇ ϕ ( ln ⁡ q ϕ ( z ) ) f ( z ) = E z ∼ q ϕ ( z ) [ ∇ ϕ ( ln ⁡ q ϕ ( z ) ) f ( z ) ] {\displaystyle \nabla _{\phi }L(\phi )=\int dz\;q_{\phi }(z)\nabla _{\phi }(\ln q_{\phi }(z))f(z)=\mathbb {E} _{z\sim q_{\phi }(z)}[\nabla _{\phi }(\ln q_{\phi }(z))f(z)]} This allows the gradient to be estimated: ∇ ϕ L ( ϕ ) ≈ 1 N ∑ i = 1 N ∇ ϕ ( ln ⁡ q ϕ ( z i ) ) f ( z i ) {\displaystyle \nabla _{\phi }L(\phi )\approx {\frac {1}{N}}\sum _{i=1}^{N}\nabla _{\phi }(\ln q_{\phi }(z_{i}))f(z_{i})} The REINFORCE estimator has high variance, and many methods were developed to reduce its variance. === Reparameterization estimator === The reparameterization trick expresses z {\displaystyle z} as: z = g ϕ ( ϵ ) , ϵ ∼ p ( ϵ ) {\displaystyle z=g_{\phi }(\epsilon ),\quad \epsilon \sim p(\epsilon )} Here, g ϕ {\displaystyle g_{\phi }} is a deterministic function parameterized by ϕ {\displaystyle \phi } , and ϵ {\displaystyle \epsilon } is a noise variable drawn from a fixed distribution p ( ϵ ) {\displaystyle p(\epsilon )} . This gives: L ( ϕ ) = E ϵ ∼ p ( ϵ ) [ f ( g ϕ ( ϵ ) ) ] {\displaystyle L(\phi )=\mathbb {E} _{\epsilon \sim p(\epsilon )}[f(g_{\phi }(\epsilon ))]} Now, the gradient can be estimated as: ∇ ϕ L ( ϕ ) = E ϵ ∼ p ( ϵ ) [ ∇ ϕ f ( g ϕ ( ϵ ) ) ] ≈ 1 N ∑ i = 1 N ∇ ϕ f ( g ϕ ( ϵ i ) ) {\displaystyle \nabla _{\phi }L(\phi )=\mathbb {E} _{\epsilon \sim p(\epsilon )}[\nabla _{\phi }f(g_{\phi }(\epsilon ))]\approx {\frac {1}{N}}\sum _{i=1}^{N}\nabla _{\phi }f(g_{\phi }(\epsilon _{i}))} == Examples == For some common distributions, the reparameterization trick takes specific forms: Normal distribution: For z ∼ N ( μ , σ 2 ) {\displaystyle z\sim {\mathcal {N}}(\mu ,\sigma ^{2})} , we can use: z = μ + σ ϵ , ϵ ∼ N ( 0 , 1 ) {\displaystyle z=\mu +\sigma \epsilon ,\quad \epsilon \sim {\mathcal {N}}(0,1)} Exponential distribution: For z ∼ Exp ( λ ) {\displaystyle z\sim {\text{Exp}}(\lambda )} , we can use: z = − 1 λ log ⁡ ( ϵ ) , ϵ ∼ Uniform ( 0 , 1 ) {\displaystyle z=-{\frac {1}{\lambda }}\log(\epsilon ),\quad \epsilon \sim {\text{Uniform}}(0,1)} Discrete distribution can be reparameterized by the Gumbel distribution (Gumbel-softmax trick or "concrete distribution") and diffusion models. In general, any distribution that is differentiable with respect to its parameters can be reparameterized by inverting the multivariable CDF function, then apply the implicit method. See for an exposition and application to the Gamma, Beta, Dirichlet, and von Mises distributions. == Applications == === Variational autoencoder === In Variational Autoencoders (VAEs), the VAE objective function, known as the Evidence Lower Bound (ELBO), is given by: ELBO ( ϕ , θ ) = E z ∼ q ϕ ( z | x ) [ log ⁡ p θ ( x | z ) ] − D KL ( q ϕ ( z | x ) | | p ( z ) ) {\displaystyle {\text{ELBO}}(\phi ,\theta )=\mathbb {E} _{z\sim q_{\phi }(z|x)}[\log p_{\theta }(x|z)]-D_{\text{KL}}(q_{\phi }(z|x)||p(z))} where q ϕ ( z | x ) {\displaystyle q_{\phi }(z|x)} is the encoder (recognition model), p θ ( x | z ) {\displaystyle p_{\theta }(x|z)} is the decoder (generative model), and p ( z ) {\displaystyle p(z)} is the prior distribution over latent variables. The gradient of ELBO with respect to θ {\displaystyle \theta } is simply E z ∼ q ϕ ( z | x ) [ ∇ θ log ⁡ p θ ( x | z ) ] ≈ 1 L ∑ l = 1 L ∇ θ log ⁡ p θ ( x | z l ) {\displaystyle \mathbb {E} _{z\sim q_{\phi }(z|x)}[\nabla _{\theta }\log p_{\theta }(x|z)]\approx {\frac {1}{L}}\sum _{l=1}^{L}\nabla _{\theta }\log p_{\theta }(x|z_{l})} but the gradient with respect to ϕ {\displaystyle \phi } requires the trick. Express the sampling operation z ∼ q ϕ ( z | x ) {\displaystyle z\sim q_{\phi }(z|x)} as: z = μ ϕ ( x ) + σ ϕ ( x ) ⊙ ϵ , ϵ ∼ N ( 0 , I ) {\displaystyle z=\mu _{\phi }(x)+\sigma _{\phi }(x)\odot \epsilon ,\quad \epsilon \sim {\mathcal {N}}(0,I)} where μ ϕ ( x ) {\displaystyle \mu _{\phi }(x)} and σ ϕ ( x ) {\displaystyle \sigma _{\phi }(x)} are the outputs of the encoder network, and ⊙ {\displaystyle \odot } denotes element-wise multiplication. Then we have ∇ ϕ ELBO ( ϕ , θ ) = E ϵ ∼ N ( 0 , I ) [ ∇ ϕ log ⁡ p θ ( x | z ) + ∇ ϕ log ⁡ q ϕ ( z | x ) − ∇ ϕ log ⁡ p ( z ) ] {\displaystyle \nabla _{\phi }{\text{ELBO}}(\phi ,\theta )=\mathbb {E} _{\epsilon \sim {\mathcal {N}}(0,I)}[\nabla _{\phi }\log p_{\theta }(x|z)+\nabla _{\phi }\log q_{\phi }(z|x)-\nabla _{\phi }\log p(z)]} where z = μ ϕ ( x ) + σ ϕ ( x ) ⊙ ϵ {\displaystyle z=\mu _{\phi }(x)+\sigma _{\phi }(x)\odot \epsilon } . This allows us to estimate the gradient using Monte Carlo sampling: ∇ ϕ ELBO ( ϕ , θ ) ≈ 1 L ∑ l = 1 L [ ∇ ϕ log ⁡ p θ ( x | z l ) + ∇ ϕ log ⁡ q ϕ ( z l | x ) − ∇ ϕ log ⁡ p ( z l ) ] {\displaystyle \nabla _{\phi }{\text{ELBO}}(\phi ,\theta )\approx {\frac {1}{L}}\sum _{l=1}^{L}[\nabla _{\phi }\log p_{\theta }(x|z_{l})+\nabla _{\phi }\log q_{\phi }(z_{l}|x)-\nabla _{\phi }\log p(z_{l})]} where z l = μ ϕ ( x ) + σ ϕ ( x ) ⊙ ϵ l {\displaystyle z_{l}=\mu _{\phi }(x)+\sigma _{\phi }(x)\odot \epsilon _{l}} and ϵ l ∼ N ( 0 , I ) {\displaystyle \epsilon _{l}\sim {\mathcal {N}}(0,I)} for l = 1 , … , L {\displaystyle l=1,\ldots ,L} . This formulation enables backpropagation through the sampling process, allowing for end-to-end training of the VAE model using stochastic gradient descent or its variants. === Variational inference === More generally, the trick allows using stochastic gradient descent for variational inference. Let the variational objective (ELBO) be of the form: ELBO ( ϕ ) = E z ∼ q ϕ ( z ) [ log ⁡ p ( x , z ) − log ⁡ q ϕ ( z ) ] {\displaystyle {\text{ELBO}}(\phi )=\mathbb {E} _{z\sim q_{\phi }(z)}[\log p(x,z)-\log q_{\phi }(z)]} Using the reparameterization trick, we can estimate the gradient of this objective with respect to ϕ {\displaystyle \phi } : ∇ ϕ ELBO ( ϕ ) ≈ 1 L ∑ l = 1 L ∇ ϕ [ log ⁡ p ( x , g ϕ ( ϵ l ) ) − log ⁡ q ϕ ( g ϕ ( ϵ l ) ) ] , ϵ l ∼ p ( ϵ ) {\displaystyle \nabla _{\phi }{\text{ELBO}}(\phi )\approx {\frac {1}{L}}\sum _{l=1}^{L}\nabla _{\phi }[\log p(x,g_{\phi }(\epsilon _{l}))-\log q_{\phi }(g_{\phi }(\epsilon _{l}))],\quad \epsilon _{l}\sim p(\epsilon )} === Dropout === The reparameterization trick has been applied to reduce the variance in dropout, a regularization technique in neural networks. The original dropout can be reparameterized with Bernoulli distributions: y = ( W ⊙ ϵ ) x , ϵ i j ∼ Bernoulli ( α i j ) {\displaystyle y=(W\odot \epsilon )x,\quad \epsilon _{ij}\sim {\text{Bernoulli}}(\alpha _{ij})} where W {\displaystyle W} is the weight matrix, x {\displaystyle x} is the input, and α i j {\displaystyle \alpha _{ij}} are the (fixed) dropout rates. More generally, other distributions can be used than the Bernoulli distribution, such as the gaussian noise: y i = μ i + σ i ⊙ ϵ i , ϵ i ∼ N ( 0 , I ) {\displaystyle y_{i}=\mu _{i}+\sigma _{i}\odot \epsilon _{i},\quad \epsilon _{i}\sim {\mathcal {N}}(0,I)} where μ i = m i ⊤ x {\displaystyle \mu _{i}=\mathbf {m} _{i}^{\top }x} and σ i 2 = v i ⊤ x 2 {\displaystyle \sigma _{i}^{2}=\mathbf {v} _{i}^{\top }x^{2}} , with m i {\displaystyle \mathbf {m} _{i}} and v i {\displaystyle \mathbf {v} _{i}} being the mean and variance of the i {\displaystyle i} -th output neuron. The reparameterization trick can be applied to all such cases, resulting in the variational dropout method.

Graphics Turing test

In computer graphics the graphics Turing test is a variant of the Turing test, the twist being that a human judge viewing and interacting with an artificially generated world should be unable to reliably distinguish it from reality. The original formulation of the test is: "The subject views and interacts with a real or computer generated scene. The test is passed if the subject can not determine reality from simulated reality better than a random guess. (a) The subject operates a remotely controlled (or simulated) robotic arm and views a computer screen. (b) The subject enters a door to a controlled vehicle or motion simulator with computer screens for windows. An eye patch can be worn on one eye, as stereo vision is difficult to simulate." The "graphics Turing scale" of computer power is then defined as the computing power necessary to achieve success in the test. It was estimated in, as 1036.8 TFlops peak and 518.4 TFlops sustained. Actual rendering tests with a Blue Gene supercomputer showed that current supercomputers are not up to the task scale yet. A restricted form of the graphic Turing test has been investigated, where test subjects look into a box, and try to tell whether the contents are real or virtual objects. For the very simple case of scenes with a cardboard pyramid or a styrofoam sphere, subjects were not able to reliably tell reality and graphics apart.