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Biopython

Biopython is an open-source collection of non-commercial Python modules for computational biology and bioinformatics. It makes robust and well-tested code easily accessible to researchers. Python is an object-oriented programming language and is a suitable choice for automation of common tasks. The availability of reusable libraries saves development time and lets researchers focus on addressing scientific questions. Biopython is constantly updated and maintained by a large team of volunteers across the globe. Biopython contains parsers for diverse bioinformatic sequence, alignment, and structure formats. Sequence formats include FASTA, FASTQ, GenBank, and EMBL. Alignment formats include Clustal, BLAST, PHYLIP, and NEXUS. Structural formats include the PDB, which contains the 3D atomic coordinates of the macromolecules. It has provisions to access information from biological databases like NCBI, Expasy, PBD, and BioSQL. This can be used in scripts or incorporated into their software. Biopython contains a standard sequence class, sequence alignment, and motif analysis tools. It also has clustering algorithms, a module for structural biology, and a module for phylogenetics analysis. == History == The development of Biopython began in 1999, and it was first released in July 2000. First "semi-complete" and "semi-stable" release was done in March 2001 and December 2002 respectively. It was developed during a similar time frame and with analogous goals to other projects that added bioinformatics capabilities to their respective programming languages, including BioPerl, BioRuby and BioJava. Early developers on the project included Jeff Chang, Andrew Dalke and Brad Chapman, though over 100 people have made contributions to date. In 2007, a similar Python project, namely PyCogent, was established. The initial scope of Biopython involved accessing, indexing and processing biological sequence files. The retrieved data from common biological databases will then be parsed into a python data structure. While this is still a major focus, over the following years added modules have extended its functionality to cover additional areas of biology. The key challenge in the design of parsers for bioinformatics file formats is the frequency at which the data formats change. This is due to inadequate curation of the structure of the data, and changes in the database contents. This problem is overcome by the application of a standard event-oriented parser design (see Key features and examples). As of version 1.77, Biopython no longer supports Python 2. The current stable release of Biopython version 1.85 was released on 15 January 2025. It only supports Python 3 and the recent releases of Biopython require NumPy (and not Numeric). == Design == Wherever possible, Biopython follows the conventions used by the Python programming language to make it easier for users familiar with Python. For example, Seq and SeqRecord objects can be manipulated via slicing, in a manner similar to Python's strings and lists. It is also designed to be functionally similar to other Bio projects, such as BioPerl. It is organized into modular sub-packages, e.g., Bio.Seq, Bio.Align, Bio.PDB, Bio.Entrez each of them useful in a different bioinformatics domain. It used principles, like encapsulation and polymorphism, notably in classes Seq, SeqRecord, and Bio.PDB.Structure. It can also interoperate with other Python tools (Pandas, Matplotlib and SciPy). Biopython can read and write most common file formats for each of its functional areas, and its license is permissive and compatible with most other software licenses, which allows Biopython to be used in a variety of software projects. == Requirements == Biopython is currently supported and tested with the following Python implementations: Python 3 or PyPy3 NumPy == Key features and examples == === Input and output === Biopython can read and write to a number of common formats. When reading files, descriptive information in the file is used to populate the members of Biopython classes, such as SeqRecord. This allows records of one file format to be converted into others. Very large sequence files can exceed a computer's memory resources, so Biopython provides various options for accessing records in large files. They can be loaded entirely into memory in Python data structures, such as lists or dictionaries, providing fast access at the cost of memory usage. Alternatively, the files can be read from disk as needed, with slower performance but lower memory requirements. === Sequences === A core concept in Biopython is the biological sequence, and this is represented by the Seq class. A Biopython Seq object is similar to a Python string in many respects: it supports the Python slice notation, can be concatenated with other sequences and is immutable. This object includes both general string-like and biological sequence-specific methods. It is best to store information about the biological type (DNA, RNA, protein) separately from the sequence, rather than using an explicit alphabet argument. === Sequence annotation === The SeqRecord class describes sequences, along with information such as name, description and features in the form of SeqFeature objects. Each SeqFeature object specifies the type of the feature and its location. Feature types can be ‘gene’, ‘CDS’ (coding sequence), ‘repeat_region’, ‘mobile_element’ or others, and the position of features in the sequence can be exact or approximate. === Accessing online databases === Through the Bio.Entrez module, users of Biopython can download biological data from NCBI databases. Each of the functions provided by the Entrez search engine is available through functions in this module, including searching for and downloading records. === Phylogeny === The Bio.Phylo module provides tools for working with and visualising phylogenetic trees. A variety of file formats are supported for reading and writing, including Newick, NEXUS and phyloXML. Common tree manipulations and traversals are supported via the Tree and Clade objects. Examples include converting and collating tree files, extracting subsets from a tree, changing a tree's root, and analysing branch features such as length or score. Rooted trees can be drawn in ASCII or using matplotlib (see Figure 1), and the Graphviz library can be used to create unrooted layouts (see Figure 2). === Genome diagrams === The GenomeDiagram module provides methods of visualising sequences within Biopython. Sequences can be drawn in a linear or circular form (see Figure 3), and many output formats are supported, including PDF and PNG. Diagrams are created by making tracks and then adding sequence features to those tracks. By looping over a sequence's features and using their attributes to decide if and how they are added to the diagram's tracks, one can exercise much control over the appearance of the final diagram. Cross-links can be drawn between different tracks, allowing one to compare multiple sequences in a single diagram. === Macromolecular structure === The Bio.PDB module can load molecular structures from PDB and mmCIF files, and was added to Biopython in 2003. The Structure object is central to this module, and it organises macromolecular structure in a hierarchical fashion: Structure objects contain Model objects which contain Chain objects which contain Residue objects which contain Atom objects. Disordered residues and atoms get their own classes, DisorderedResidue and DisorderedAtom, that describe their uncertain positions. Using Bio.PDB, one can navigate through individual components of a macromolecular structure file, such as examining each atom in a protein. Common analyses can be carried out, such as measuring distances or angles, comparing residues and calculating residue depth. === Population genetics === The Bio.PopGen module adds support to Biopython for Genepop, a software package for statistical analysis of population genetics. This allows for analyses of Hardy–Weinberg equilibrium, linkage disequilibrium and other features of a population's allele frequencies. This module can also carry out population genetic simulations using coalescent theory with the fastsimcoal2 program. === Wrappers for command line tools === Biopython previously included command-line wrappers for tools such as BLAST, Clustal, EMBOSS, and SAMtools. This option allowed users to run external tool commands from within the code using specialized Biopython classes. However, Bio.Application modules and their wrappers have deprecated and will be removed in future Biopython releases. The main reason for this is the high maintenance burden of updating them with the evolving external tools. The recommended approach is to directly construct and execute command-line tool commands using Python’s built-in subprocess module. This method provides flexibility and removes the dependency on the Biopython wrappers. subprocess is a native Python module useful for running ext
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Ω-automaton

In automata theory, a branch of theoretical computer science, an ω-automaton (or stream automaton) is a variation of a finite automaton that runs on infinite, rather than finite, strings as input. Since ω-automata do not stop, they have a variety of acceptance conditions rather than simply a set of accepting states. ω-automata are useful for specifying behavior of systems that are not expected to terminate, such as hardware, operating systems and control systems. For such systems, one may want to specify a property such as "for every request, an acknowledge eventually follows", or its negation "there is a request that is not followed by an acknowledge". The former is a property of infinite words: one cannot say of a finite sequence that it satisfies this property. Classes of ω-automata include the Büchi automata, Rabin automata, Streett automata, parity automata and Muller automata, each deterministic or non-deterministic. These classes of ω-automata differ only in terms of acceptance condition. They all recognize precisely the regular ω-languages except for the deterministic Büchi automata, which is strictly weaker than all the others. Although all these types of automata recognize the same set of ω-languages, they nonetheless differ in succinctness of representation for a given ω-language. == Deterministic ω-automata == Formally, a deterministic ω-automaton is a tuple A = ( Q , Σ , δ , q 0 , A a c c ) {\textstyle A=(Q,\Sigma ,\delta ,q_{0},A_{acc})} , that consists of the following components: Q {\textstyle Q} , is a finite set. The elements of Q {\textstyle Q} are called the states of A {\textstyle A} . Σ {\textstyle \Sigma } , is a finite set called the alphabet of A {\textstyle A} . δ : Q × Σ → Q {\textstyle \delta \colon Q\times \Sigma \rightarrow Q} is a function, called the transition function of A {\textstyle A} . Q 0 {\textstyle Q_{0}} is an element of Q {\textstyle Q} , called the initial state. A a c c {\textstyle A_{acc}} is a set of accepting states of A {\textstyle A} , formally a subset of Q ω {\textstyle Q^{\omega }} . An input for A {\textstyle A} is an infinite string over the alphabet Σ {\textstyle \Sigma } , i.e. it is an infinite sequence α = ( a 1 , a 2 , a 3 , … ) {\textstyle \alpha =(a_{1},a_{2},a_{3},\ldots )} . The run of A {\textstyle A} on such an input is an infinite sequence ρ = ( r 0 , r 1 , r 2 , … ) {\textstyle \rho =(r_{0},r_{1},r_{2},\ldots )} of states, defined as follows: r 0 = q 0 {\textstyle r_{0}=q_{0}} . r 1 = δ ( r 0 , a 1 ) {\textstyle r_{1}=\delta (r_{0},a_{1})} . r 2 = δ ( r 1 , a 2 ) {\textstyle r_{2}=\delta (r_{1},a_{2})} . ... that is, for every i {\textstyle i} : r i = δ ( r i − 1 , a i ) {\textstyle r_{i}=\delta (r_{i-1},a_{i})} . The main purpose of an ω-automaton is to define a subset of the set of all inputs: The set of accepted inputs. Whereas in the case of an ordinary finite automaton every run ends with a state r n {\textstyle r_{n}} and the input is accepted if and only if r n {\textstyle r_{n}} is an accepting state, the definition of the set of accepted inputs is more complicated for ω-automata. Here we must look at the entire run ρ {\textstyle \rho } . The input is accepted if the corresponding run is in Acc {\textstyle {\text{Acc}}} . The set of accepted input ω-words is called the recognized ω-language by the automaton, which is denoted as L ( A ) {\textstyle L(A)} . The definition of Acc {\textstyle {\text{Acc}}} as a subset of Q ω {\textstyle Q^{\omega }} is purely formal and not suitable for practice because normally such sets are infinite. The difference between various types of ω-automata (Büchi, Rabin etc.) consists in how they encode certain subsets Acc {\textstyle {\text{Acc}}} of Q ω {\textstyle Q^{\omega }} as finite sets, and therefore in which such subsets they can encode. == Nondeterministic ω-automata == Formally, a nondeterministic ω-automaton is a tuple A = ( Q , Σ , Δ , Q 0 , Acc ) {\textstyle A=(Q,\Sigma ,\Delta ,Q_{0},{\text{Acc}})} that consists of the following components: Q {\textstyle Q} is a finite set. The elements of Q {\textstyle Q} are called the states of A {\textstyle A} . Σ {\textstyle \Sigma } is a finite set called the alphabet of A {\textstyle A} . Δ {\textstyle \Delta } is a subset of Q × Σ × Q {\textstyle Q\times \Sigma \times Q} and is called the transition relation of A {\textstyle A} . Q 0 {\textstyle Q_{0}} is a subset of Q {\textstyle Q} , called the initial set of states. Acc {\textstyle {\text{Acc}}} is the acceptance condition, a subset of Q ω {\textstyle Q^{\omega }} . Unlike a deterministic ω-automaton, which has a transition function δ {\textstyle \delta } , the non-deterministic version has a transition relation Δ {\textstyle \Delta } . Note that Δ {\textstyle \Delta } can be regarded as a function Q × Σ → P ( Q ) {\textstyle Q\times \Sigma \rightarrow {\mathcal {P}}(Q)} from Q × Σ {\textstyle Q\times \Sigma } to the power set P ( Q ) {\textstyle {\mathcal {P}}(Q)} . Thus, given a state q n {\textstyle q_{n}} and a symbol a n {\textstyle a_{n}} , the next state q n + 1 {\textstyle q_{n+1}} is not necessarily determined uniquely, rather there is a set of possible next states. A run of A {\textstyle A} on the input α = ( a 1 , a 2 , a 3 , … ) {\textstyle \alpha =(a_{1},a_{2},a_{3},\ldots )} is any infinite sequence ρ = ( r 0 , r 1 , r 2 , … ) {\textstyle \rho =(r_{0},r_{1},r_{2},\ldots )} of states that satisfies the following conditions: r 0 {\textstyle r_{0}} is an element of Q 0 {\textstyle Q_{0}} . r 1 {\textstyle r_{1}} is an element of Δ ( r 0 , a 1 ) {\textstyle \Delta (r_{0},a_{1})} . r 2 {\textstyle r_{2}} is an element of Δ ( r 1 , a 2 ) {\textstyle \Delta (r_{1},a_{2})} . ... that is, for every i {\textstyle i} : r i {\textstyle r_{i}} is an element of Δ ( r i − 1 , a i ) {\textstyle \Delta (r_{i-1},a_{i})} . A nondeterministic ω-automaton may admit many different runs on any given input, or none at all. The input is accepted if at least one of the possible runs is accepting. Whether a run is accepting depends only on Acc {\textstyle {\text{Acc}}} , as for deterministic ω-automata. Every deterministic ω-automaton can be regarded as a nondeterministic ω-automaton by taking Δ {\textstyle \Delta } to be the graph of δ {\textstyle \delta } . The definitions of runs and acceptance for deterministic ω-automata are then special cases of the nondeterministic cases. == Acceptance conditions == Acceptance conditions may be infinite sets of ω-words. However, people mostly study acceptance conditions that are finitely representable. The following lists a variety of popular acceptance conditions. Before discussing the list, let's make the following observation. In the case of infinitely running systems, one is often interested in whether certain behavior is repeated infinitely often. For example, if a network card receives infinitely many ping requests, then it may fail to respond to some of the requests but should respond to an infinite subset of received ping requests. This motivates the following definition: For any run ρ {\textstyle \rho } , let Inf ( ρ ) {\textstyle {\text{Inf}}(\rho )} be the set of states that occur infinitely often in ρ {\textstyle \rho } . This notion of certain states being visited infinitely often will be helpful in defining the following acceptance conditions. A Büchi automaton is an ω-automaton A {\textstyle A} that uses the following acceptance condition, for some subset F {\textstyle F} of Q {\textstyle Q} : Büchi condition A {\textstyle A} accepts exactly those runs ρ {\textstyle \rho } for which Inf ( ρ ) ∩ F ≠ ∅ {\textstyle {\text{Inf}}(\rho )\cap F\neq \emptyset } , i.e. there is an accepting state that occurs infinitely often in ρ {\textstyle \rho } . A Rabin automaton is an ω-automaton A {\textstyle A} that uses the following acceptance condition, for some set Ω {\textstyle \Omega } of pairs ( B i , G i ) {\textstyle (B_{i},G_{i})} of sets of states: Rabin condition A {\textstyle A} accepts exactly those runs ρ {\textstyle \rho } for which there exists a pair ( B i , G i ) {\textstyle (B_{i},G_{i})} in Ω {\textstyle \Omega } such that B i ∩ Inf ( ρ ) = ∅ {\textstyle B_{i}\cap {\text{Inf}}(\rho )=\emptyset } and G i ∩ Inf ( ρ ) ≠ ∅ {\textstyle G_{i}\cap {\text{Inf}}(\rho )\neq \emptyset } . A Streett automaton is an ω-automaton A {\textstyle A} that uses the following acceptance condition, for some set Ω {\textstyle \Omega } of pairs ( B i , G i ) {\textstyle (B_{i},G_{i})} of sets of states: Streett condition A {\textstyle A} accepts exactly those runs ρ {\textstyle \rho } such that for all pairs ( B i , G i ) {\textstyle (B_{i},G_{i})} in Ω {\textstyle \Omega } , B i ∩ Inf ( ρ ) ≠ ∅ {\textstyle B_{i}\cap {\text{Inf}}(\rho )\neq \emptyset } or G i ∩ Inf ( ρ ) = ∅ {\textstyle G_{i}\cap {\text{Inf}}(\rho )=\emptyset } . A parity automaton is an automaton A {\textstyle A} whose set of states is Q = { 0 , 1 , 2 , … , k } {\textstyle Q=\{0,1,2,\ldots ,k\}} for some natural number k {\textst
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Liz Liddy

Elizabeth DuRoss Liddy (May 12, 1944 – August 21, 2025) was an American computer scientist and academic who was professor of information science and dean of the Syracuse University School of Information Studies. She was a pioneer in the field of natural language processing. == Early life and education == Liddy was born in Dayton, Ohio, on May 14, 1944, and grew up in Utica, New York. She was one of five children, all of whom worked in her father's family business. Liddy attended St. Francis DeSalle High School, where she was awarded a Regent's Scholarship, and eventually attended Daemen College. She was literary editor of her high school year book and edited a literary magazine during her time at college. At Daemen College Liddy studied English language and literature. After graduating Liddy remained in New York, where she volunteered in an elementary school library. She joined the Syracuse University School of Information Studies in 1983, where she started a graduate program in library science. She worked as a faculty librarian at Onondaga Community College whilst earning her degree. Here Liddy worked as a Visiting assistant professor, whilst completing her doctorate part-time in information transfer. Her dissertation research involved natural language processing, a computerized approach to analyzing text. She was hired to the faculty at Syracuse University whilst completing her PhD. == Research and career == In 1994 Liddy was the founding President of TextWise, a semantics-based search engine. The first product she developed was called Document Retrieval Using Linguistic Knowledge (DR-LINK). She left TextWise in 1999, after growing the number of employees to over 50. She started the Syracuse University Center for Natural Language Processing in 1999, and was honored with the university's Outstanding Alumni Award the following year. Liddy was appointed Dean of the School of Information Studies (iSchool) in 2008, and held the position for over ten years. She temporarily left the role in 2015. The school was transformed under her leadership, increasing the enrollment of students by over 70% and launching a graduate certificate in data science. She raised over $20 million to support research and development at Syracuse University. She chaired the iSchool Organization, which connects information science schools all over the world, from 2012 to 2014. Liddy worked to increase the representation of women at the iSchool, through initiatives such as the IT Girls Overnight Retreat – an annual weekend to introduce high school girls to Information Technology. She improved the career development programs of students at Syracuse University, increasing student employment to almost 100% post graduation. Liddy retired as Dean of the iSchool in 2019. === Selected innovations === US 6026388, Liddy, Elizabeth D., "User interface and other enhancements for natural language information retrieval system and method", published August 16, 1995, issued February 15, 2000 US 5963940, Liddy, Elizabeth D., "Natural language information retrieval system and method", published August 16, 1995, issued October 5, 1999 US 6006221, Liddy, Elizabeth D., "Multilingual document retrieval system and method using semantic vector matching", published August 16, 1995, issued December 21, 1999 == Personal life and death == Liddy was married shortly after graduating Daemen College in 1966. She had three children. Liddy died in Charlotte, North Carolina, on August 21, 2025, at the age of 81.
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Alex James (professor)

Alex James is an Indian scientist who is a professor of AI hardware at School of Electronic Systems and Automation, and Dean at Digital University Kerala (IIITM-K). He is the professor in charge of Maker Village, Kochi, Chief Investigator of the centre for Intelligent IoT Sensors, and India Innovation Centre for Graphene. James features in top 1% scientists list published by Elsevier BV in the world in the field of Electrical and Electronics Engineering. He appeared in the list for the third consecutive time. He specializes in the scientific field of Memristive Systems, AI hardware, Neuromorphic VLSI (very-large-scale integration) system, Intelligent Imaging and Machine learning, and Analogue electronics. == Education and career == James earned his Ph.D. degree from the Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, Australia. Since 2009, he has been working as a faculty member at different universities in Australia and India. He was a Member of IET Vision and Imaging Network, and is a Member of BCS’ Fellows Technical Advisory Group (F-TAG). He is the founding chair for IEEE Kerala Section Circuits and Systems Society, and is a fellow of British Computer Society (FBCS), and Institution of Engineering and Technology. He was an Editorial Board Member of Information Fusion (2010–2014), Elsevier, and associate editor for HCIS (2015–2020), Springer; and Guest Associate Editor for IEEE Transactions on Emerging Topics in Computational Intelligence (2017). Currently he is serving as an Associate Editor of IEEE Access, Frontiers in Neuroscience, and IEEE Transactions on Circuits and Systems I: Regular Papers journal. == Scientific research == IIITM-K has achieved a breakthrough in developing Analogue Integrated circuit for implementing Generative Adversarial Networks (GAN) in a joint research project with Analogue Circuits and Image Sensors Lab, Siegen university and Fraunhofer, Germany, and Centre for Excellence in Artificial general intelligence and Neuromorphic Systems (neuroAGI). According to A. P. James, professor at the School of Electronics at IIITM-K, this complicated and meticulous AI circuits research can accelerate and operate GAN applications in low power devices. It also can be used to analyze and interpret 2019-nCoV data for a possible solution to the pandemic. An AI Semantic search engine has been created by a research team led by A.P. James to help researchers gain deeper insights into Scientific Investigation, particularly since the COVID-19 issue has necessitated the collection of a significant amount of complex scientific data. The search engine is called "www.vilokana.in, which is Sanskrit for "finding out. == Awards and honors == James is a member of IEEE CASS Technical committee on Nonlinear Circuits and Systems, IEEE CASS Technical committee on Cellular Nanoscale networks and Memristor Array Computing, IEEE Consumer Technology Society Technical Committee on Quantum in Consumer Technology (QCT), Technical Committee on Machine learning, Deep learning and AI in CE (MDA) and Member of BCS’ Fellows Technical Advisory Group (F-TAG). James was awarded best associate editor of IEEE Transactions on Circuits and Systems I: Regular Papers TCAS-I, by the IEEE Circuits and Systems Society (IEEE CASS) for the year 2020–21. He has been an associate editor for the journal since 2017. He is also an editorial board member of PeerJ CS and a Senior Member of IEEE, Life Member of ACM, Senior Fellow of HEA.
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Ultra Hal

Ultra Hal is a chatbot intended to function as a virtual assistant. It was developed by Zabaware, Inc. Ultra Hal uses a natural language interface with animated characters using speech synthesis. Users can communicate with the chatterbot via typing or via a speech recognition engine. It utilizes the WordNet lexical dictionary. Its name is an allusion to HAL 9000, the artificial intelligence from the movie 2001: A Space Odyssey. Ultra Hal won the 2007 Loebner Prize for "most human" chatterbot.
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Marilyn Walker

Marilyn A. Walker is an American computer scientist. She is professor of computer science and head of the Natural Language and Dialogue Systems Lab at the University of California, Santa Cruz (UCSC). Her research includes work on computational models of dialogue interaction and conversational agents, analysis of affect, sarcasm and other social phenomena in social media dialogue, acquiring causal knowledge from text, conversational summarization, interactive story and narrative generation, and statistical methods for training the dialogue manager and the language generation engine for dialogue systems. == Biography == Walker received an M.S. in Computer Science from Stanford University in 1987, and a Ph.D. in Computer and Information Science and an M.A in linguistics from the University of Pennsylvania in 1993. Walker was awarded a Royal Society Wolfson Research Fellowship at the University of Sheffield from 2003 to 2009. She was inducted as a Fellow of the Association for Computational Linguistics (ACL) in December 2016 for "fundamental contributions to statistical methods for dialog optimization, to centering theory, and to expressive generation for dialog". She served as the general chair of the 2018 North American Association for Computational Linguistics (NAACL-2018) conference. Walker pioneered the use of statistical methods for dialog optimization at AT&T Bell Labs Research where she conducted some of the first experiments on reinforcement learning for optimizing dialogue systems. Her research on Centering Theory is taught in standard textbooks on NLP. She also pioneered the use of statistical NLP methods for Natural Language Generation with the development of the first statistical sentence planner for dialogue systems in 2001. She is well known for her work with François Mairesse on recognizing Big Five personality from text as well as using statistical methods for stylistic Natural Language Generation to express a particular Big Five personality type. An extension of this work learns how to manifest the linguistic style of a particular character in a film. She has published over 300 papers and is the holder of 10 U.S. patents. Her work on the evaluation of dialogue systems conducted at AT&T Bell Labs Research (PARADISE: A framework for evaluating spoken dialogue agents) is a classic, has been cited more than 1100 times. At UCSC, her lab focuses on computational modeling of dialogue and user-generated content in social media such as weblogs, including spoken dialogue systems and interactive stories. She led the Athena team, which was selected as a contender in the Alexa Prize SocialBot Challenge for 5 challenges between 2018 and 2023.
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Top 10 AI Video Editors Compared (2026)

Looking for the best AI video editor? An AI video editor is software that uses machine learning to help you get more done — it can save you hours every week by automating repetitive work. Most options offer a generous free tier, with paid plans unlocking higher limits, faster processing, and team features. Whether you are a beginner or a pro, the right AI video editor slots into your workflow and pays for itself fast. Read on for hands-on impressions, pricing tiers, and the standout features that matter.
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Neuroph

Neuroph is an object-oriented artificial neural network framework written in Java. It can be used to create and train neural networks in Java programs. Neuroph provides Java class library as well as GUI tool easyNeurons for creating and training neural networks. It is an open-source project hosted at SourceForge under the Apache License. Versions before 2.4 were licensed under LGPL 3, from this version the license is Apache 2.0 License. == Features == Neuroph's core classes correspond to basic neural network concepts like artificial neuron, neuron layer, neuron connections, weight, transfer function, input function, learning rule etc. Neuroph supports common neural network architectures such as Multilayer perceptron with Backpropagation, Kohonen and Hopfield networks. All these classes can be extended and customized to create custom neural networks and learning rules. Neuroph has built-in support for image recognition.
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PatchMatch

PatchMatch is an algorithm used to quickly find correspondences (or matches) between small square regions (or patches) of an image. It has various applications in image editing, such as reshuffling or removing objects from images or altering their aspect ratios without cropping or noticeably stretching them. PatchMatch was first presented in a 2011 paper by researchers at Princeton University. == Algorithm == The goal of the algorithm is to find the patch correspondence by defining a nearest-neighbor field (NNF) as a function f : R 2 → R 2 {\displaystyle f:\mathbb {R} ^{2}\to \mathbb {R} ^{2}} of offsets, which is over all possible matches of patch (location of patch centers) in image A, for some distance function of two patches D {\displaystyle D} . So, for a given patch coordinate a {\displaystyle a} in image A {\displaystyle A} and its corresponding nearest neighbor b {\displaystyle b} in image B {\displaystyle B} , f ( a ) {\displaystyle f(a)} is simply b − a {\displaystyle b-a} . However, if we search for every point in image B {\displaystyle B} , the work will be too hard to complete. So the following algorithm is done in a randomized approach in order to accelerate the calculation speed. The algorithm has three main components. Initially, the nearest-neighbor field is filled with either random offsets or some prior information. Next, an iterative update process is applied to the NNF, in which good patch offsets are propagated to adjacent pixels, followed by random search in the neighborhood of the best offset found so far. Independent of these three components, the algorithm also uses a coarse-to-fine approach by building an image pyramid to obtain the better result. === Initialization === When initializing with random offsets, we use independent uniform samples across the full range of image B {\displaystyle B} . This algorithm avoids using an initial guess from the previous level of the pyramid because in this way the algorithm can avoid being trapped in local minima. === Iteration === After initialization, the algorithm attempted to perform iterative process of improving the N N F {\displaystyle NNF} . The iterations examine the offsets in scan order (from left to right, top to bottom), and each undergoes propagation followed by random search. === Propagation === We attempt to improve f ( x , y ) {\displaystyle f(x,y)} using the known offsets of f ( x − 1 , y ) {\displaystyle f(x-1,y)} and f ( x , y − 1 ) {\displaystyle f(x,y-1)} , assuming that the patch offsets are likely to be the same. That is, the algorithm will take new value for f ( x , y ) {\displaystyle f(x,y)} to be arg ⁡ min ( x , y ) D ( f ( x , y ) ) , D ( f ( x − 1 , y ) ) , D ( f ( x , y − 1 ) ) {\displaystyle \arg \min \limits _{(x,y)}{D(f(x,y)),D(f(x-1,y)),D(f(x,y-1))}} . So if f ( x , y ) {\displaystyle f(x,y)} has a correct mapping and is in a coherent region R {\displaystyle R} , then all of R {\displaystyle R} below and to the right of f ( x , y ) {\displaystyle f(x,y)} will be filled with the correct mapping. Alternatively, on even iterations, the algorithm search for different direction, fill the new value to be arg ⁡ min ( x , y ) { D ( f ( x , y ) ) , D ( f ( x + 1 , y ) ) , D ( f ( x , y + 1 ) ) } {\displaystyle \arg \min \limits _{(x,y)}\{D(f(x,y)),D(f(x+1,y)),D(f(x,y+1))\}} . === Random search === Let v 0 = f ( x , y ) {\displaystyle v_{0}=f(x,y)} , we attempt to improve f ( x , y ) {\displaystyle f(x,y)} by testing a sequence of candidate offsets at an exponentially decreasing distance from v 0 {\displaystyle v_{0}} u i = v 0 + w α i R i {\displaystyle u_{i}=v_{0}+w\alpha ^{i}R_{i}} where R i {\displaystyle R_{i}} is a uniform random in [ − 1 , 1 ] × [ − 1 , 1 ] {\displaystyle [-1,1]\times [-1,1]} , w {\displaystyle w} is a large window search radius which will be set to maximum picture size, and α {\displaystyle \alpha } is a fixed ratio often assigned as 1/2. This part of the algorithm allows the f ( x , y ) {\displaystyle f(x,y)} to jump out of local minimum through random process. === Halting criterion === The often used halting criterion is set the iteration times to be about 4~5. Even with low iteration, the algorithm works well.
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AI Customer-support Bots Reviews: What Actually Works in 2026

Looking for the best AI customer-support bot? An AI customer-support bot is software that uses machine learning to help you get more done — it can save you hours every week by automating repetitive work. Most options offer a generous free tier, with paid plans unlocking higher limits, faster processing, and team features. Whether you are a beginner or a pro, the right AI customer-support bot slots into your workflow and pays for itself fast. Read on for hands-on impressions, pricing tiers, and the standout features that matter.
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The Best Free AI Paragraph Rewriter for Beginners

Shopping for the best AI paragraph rewriter? An AI paragraph rewriter is software that uses machine learning to help you get more done — it keeps getting smarter as the underlying models improve. Pricing, accuracy, and the size of the model behind the tool are the three factors that most affect daily usefulness. Whether you are a beginner or a pro, the right AI paragraph rewriter slots into your workflow and pays for itself fast. We tested the leading options and ranked them by quality, value, and ease of use.
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Jacek M. Zurada

Jacek M. Zurada is a Polish-American computer scientist who is a Professor of the Electrical and Computer Engineering Department at the University of Louisville, Kentucky. His M.S. and Ph.D. degrees are from Politechnika Gdaṅska (Gdansk University of Technology, Poland). He has held visiting appointments at the Swiss Federal Institute of Technology, Zurich, Princeton, Northeastern, and Auburn, and at overseas universities in Australia, Chile, China, France, Germany, Hong Kong, Italy, Japan, Poland, Singapore, Spain, and South Africa. He is a life fellow of IEEE and a fellow of the International Neural Networks Society and Doctor Honoris Causa of Czestochowa Institute of Technology, Poland. == Research == Zurada's research covers neural networks, deep learning, data mining with emphasis on data and feature understanding, rule extraction from semantic and visual information, machine learning, decomposition methods for salient feature extraction, and lambda learning rule for neural networks. == Professional and editorial service == Zurada was the editor-in-chief of IEEE Transactions on Neural Networks (1998–2003), an associate editor of IEEE Transactions on Circuits and Systems, Pt. I and Pt. II, Action Editor in Neural Networks (Elsevier) and on the editorial board of the Proceedings of the IEEE. He is an associate editor of Neurocomputing, Schedae Informaticae, the International Journal of Applied Mathematics and Computer Science, and Editor of the Springer Natural Computing, Advances in Intelligent Systems and Computing and Studies in Computational Intelligence Book series or volumes. == Awards and honours == In 2003 he was given the title of Professor by the President of Poland. Since 2005 he has been an elected Foreign Member of the Polish Academy of Sciences. He also received five honorary professorships from foreign universities, including Sichuan University in Chengdu, China, and Obuda University in Budapest, Hungary.
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Cybersecurity in space

Cybersecurity in space involves the defense of all space assets (e.g. navigation systems, satellites, ground antennas, networks, etc.). The security of space can be affected by attacks such as disruption, corruption as well as the destruction of depended-upon assets/collected data. Government (e.g. militaries) and non-government sectors (e.g. financial industries) have started to become more reliant on numerous space-based services. Due to the criticality of these services, space security experts have identified these assets as high-value targets (HVT) that can cause detrimental consequences to all of Earth. == Scope and definitions == Space assets are broken down by three sub-sectors: the space component, the ground component, and the individual user component. The architecture of space assets is extremely complex and allows for a frequent attack vector utilized, the disruption by radio frequency (RF) cyber-attacks. In 2020, a memorandum was published by President Donald Trump, Space Policy Directive‑5 (SPD‑5). It established principles to ensure the safeguarding of all space assets. In 2023, the National Institute of Standards and Technology’s (NIST) published IR 8270, Introduction to Cybersecurity for Commercial Satellite Operations. This report established a baseline risk-management framework (RMF) to be implemented into space operations. == History == During the Cold War in the 1950s-1960s, the United States and Russia entered what was called the “Space Race”. By 1957, the Soviet Union successfully launched the first satellite into space named Sputnik. By 1961, the first key milestone was accomplished when the Soviet Union’s Yuri Gagarin became the first human to orbit Earth. This was later followed by the first American, Alan Shepard, to be launched into space; this was followed by John Glenn becoming the first American to orbit Earth in 1962. In 1969, a pinnacle milestone was reached when Apollo 11 launched into space and Neil Armstrong became the first man to walk on the moon. As space operations furthered, Commercial off-the-shelf products became increasingly popular but resulted in a rapid increase to the cyber-attack surface. Public awareness of space security did not increase until 2022, when the Viasat KA-SAT incident occurred, resulting in the disruption of a large number of modems across Europe. The attack was later accredited to Russia by the U.S. and the U.K. Policy and standards started to rapidly increase by 2020. The establishment of SPD-5 was released in 2020 followed by asset hardening instructions in 2022, and NIST’s IR 8270 in 2023. It was not until 2025 that Europe published their own findings in the Space Threat Landscape 2025 Report. This document led to the EU’s security proposals and standards. == Threats == === Radio-frequency Interference and Global Navigation Satellite Systems (GNSS) Spoofing === Space services are highly dependent on RF links for systems such as GNSS, however, a consequence of this dependency on RF is denial of service and deception. In 2017, the Black Sea maritime event occurred when numerous ships were subject to spoofing. Space services depend on RF links susceptible to jamming (denial) and spoofing (deception), including for GNSS/Positioning, Navigation, and Timing (PNT). Annotated incidents include the 2017 Black Sea maritime spoofing event affecting numerous ships, and extensive aviation GNSS spoofing patterns surveyed in various regions during 2024–2025. === Network intrusion and malware === Cyber threats can intrude and infect assets with malware. They do this by finding misconfiguration vulnerabilities, remote-management interfaces, and/or supply-chain vulnerabilities mainly in ground networks and user terminals. When KA-SAT occurred, it resulted from bulk modem disturbances. Forensic analysts later suggested malicious management controls and wiper malware as the root cause. === Supply-chain and lifecycle risks === The outsource of COTS components, external vendors, and software defined payloads allowed for vulnerabilities to emerge in the System/Product Lifecycle. In response, EU recommended the implementation of lifecycle-wide controls as mitigating factors. === Espionage, disruption, and influence === As Advanced Persistent Threats (APTs), Global Positioning System (GPS) intervention, and information warfare increased, assets like transponders became more frequent targets of attack. == Noteworthy incidents == The Viasat KA‑SAT incident of 2022, where a large number of modems in Europe were disrupted, resulted in the loss of telemetry access to a significant amount of wind turbines in Germany. The mass GNSS deception of the Black Sea in 2017 affected numerous ships when they started to convey fake central locations in Russia. Between 2024 and 2025, there was a mass, repetitive aviation GNSS spoofing that affected the aircraft of various regions. == Standards, guidelines, and best practices == SPD‑5 (U.S.) – This established risk-based engineering, verifying and ensuring positive control, and the implementation of risk mitigation controls. NIST IR 8270 – This created a RMF for COTS satellites. CISA/FBI SATCOM Advisory (AA22‑076) – Provided guidance on hardening techniques such as least-privileged, access control, encryption, etc.). ENISA Space Threat Landscape 2025 – It established the categorization of assets to organize threats, ensuring the observation of system/product lifecycle, and an RMF for COTS satellites. ECSS‑E‑ST‑80C (2024) – This established a standard for securing lifecycles in space, covering all segments (e.g. ground, launch, etc.). == Regulation and governance == As of 2025, there is no international regulations established for space assets, but the U.S., EU, and ESA institutional initiatives have published standards to address security concerns. The U.S. implemented SPD-5 and the Federal Communications Commission (FCC); the FCC addressed orbital debris. While the EU created standards to address technological mandates and support the implementation of NIS2. Lastly, the ESA created a special operations center to safeguard their satellites. International governance is still evolving, but forums have been held by the United Nations Committee on the Peaceful Uses of Outer Space. International conversations under forums such as the UN Committee on the Peaceful Uses of Outer Space (COPUOS) progressively note the cyber–space safety relationship, though formal global norms specific to space cybersecurity continue evolving. == Risk management approaches == Through RMF, mitigation controls have been implemented to reduce the risk of exploitation while increasing the security of space. Controls addressing mitigation include proper configuration, system hardening, zero-trust architectures, encryption, etc. Both the government and industries have placed an emphasis on incident response procedures to identify, contain, and remediate breaches.
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AI Resume Builders Reviews: What Actually Works in 2026

Shopping for the best AI resume builder? An AI resume builder is software that uses machine learning to help you get more done — it keeps getting smarter as the underlying models improve. Pricing, accuracy, and the size of the model behind the tool are the three factors that most affect daily usefulness. Whether you are a beginner or a pro, the right AI resume builder slots into your workflow and pays for itself fast. We tested the leading options and ranked them by quality, value, and ease of use.
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Global Language Monitor

The Global Language Monitor (GLM) is a company based in Austin, Texas, that analyzes trends in the English language. == History == Founded in Silicon Valley in 2003 by Paul J.J. Payack, the GLM describes its role as "a media analytics company that documents, analyzes and tracks cultural trends in language the world over, with a particular emphasis upon International and Global English". In April 2008, GLM moved its headquarters from San Diego to Austin. In July 2020, GLM announced that the word covid was its Top Word of 2020 for English. The company has been repeatedly criticized by linguists for promoting misinformation about language. Writing on Language Log, the linguist Ben Zimmer accused it of "hoodwink[ing] unsuspecting journalists on a range of pseudoscientific claims".
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