AI Analytical Thinking

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  Pharmacy automation

  Pharmacy automation involves the mechanical processes of handling and distributing medications. Any pharmacy task may be involved, including counting small objects (e.g., tablets, capsules); measuring and mixing powders and liquids for compounding; tracking and updating customer information in databases (e.g., personally identifiable information (PII), medical history, drug interaction risk detection); and inventory management. This article focuses on the changes that have taken place in the local, or community pharmacy since the 1960s. == History == Dispensing medications in a community pharmacy before the 1970s was a time-consuming operation. The pharmacist dispensed prescriptions in tablet or capsule form with a simple tray and spatula. Many new medications were developed by pharmaceutical manufacturers at an ever-increasing pace, and medications prices were rising steeply. A typical community pharmacist was working longer hours and often forced to hire staff to handle increased workloads which resulted in less time to focus on safety issues. These additional factors led to use of a machine to count medications. The original electronic portable digital tablet counting technology was invented in Manchester, England between 1967 and 1970 by the brothers John and Frank Kirby. I had the original idea of how the machine would work and it was my patent, but it was a joint effort getting it to work in a saleable form. It was 3 years of very hard work. I had originally studied heavy electrical engineering before changing over to Medical School and qualifying as a Medical Doctor in 1968. In fact I was Senior House (Casualty) Officer (A&E or ER) in 1970 at North Manchester General Hospital when I filed the patent. I must have been the only hospital doctor in Britain with an oscilloscope, a soldering iron and a drawing board in his room in the Doctors' Residence. The housekeepers were bemused by all the wires. Frank originally trained as a Banker but quit to take a job with a local electronics firm during the development. He died in 1987, a terrible loss. [Extract from personal communication received in March 2010 from John Kirby.] Frank and John Kirby and their associate Rodney Lester were pioneers in pharmacy automation and small-object counting technology. In 1967, the Kirbys invented a portable digital tablet counter to count tablets and capsules. With Lester they formed a limited company. In 1970, their invention was patented and put into production in Oldham, England. The tablet counter aided the pharmacy industry with time-consuming manual counting of drug prescriptions. A counting machine consistently counted medications accurately and quickly. This aspect of pharmacy automation was quickly adopted, and innovations emerged every decade to aid the pharmacy industry to deliver medications quickly, safely, and economically. Modern pharmacies have many new options to improve their workflow by using the new technology, and can choose intelligently from the many options available. === Chronology === On 1 January 1971 commercial production of the first portable digital tablet counters in the World began. John Kirby had filed U.K. Patent number GB1358378(A) on 8 September 1970 and U.S. patent number 3789194 on 9 August 1971. These early electronic counters were designed to help pharmacies replace the common (but often inaccurate) practice of counting medications by hand. In 1975, the digital technology was exported to America. In early 1980 a dedicated research, development and production facility was built in Oldham, England at a cost of £500,000. Between 1982 and 1983, two separate development facilities had been created. In America, overseen by Rodney Lester; and in England, overseen by the Kirby brothers. In 1987, Frank Kirby died. In 1989, John Kirby moved his UK facility to Devon, England. A simple to operate machine had been developed to accurately and quickly count prescription medications. Technology improvements soon resulted in a more compact model. The price of such equipment in 1980 was around £1,300. This substantial investment in new technology was a major financial consideration, but the pharmacy community considered the use of a counting machine as a superior method compared to hand-counting medications. These early devices became known as tablet counter, capsule counter, pill counter, or drug counter. The new counting technology replaced manual methods in many industries such as, vitamin and diet supplement manufacturing. Technicians needed a small, affordable device to count and bottle medications. In England and America, the 1980s and 1990s saw new the development of high-speed machines for counting and bottle filling, Like their pharmacy-based counterparts, these industrial units were designed to be fast and simple to operate, yet remain small and cost effective. In America, in the late 1990s/early 2000s a new type of tablet counter appeared. It was simple to use, compact, inexpensive, and had good counting accuracy. At the turn of the millennium technical advances allowed the design of counters with a software verification system. With an onboard computer, displaying photo images of medications to assist the pharmacist or pharmacy technician to verify that the correct medication was being dispensed. In addition, a database for storing all prescriptions that were counted on the device. Between September 2005 and May 2007, American Capital made a major financial investment in Kirby Lester, which then relocated to a larger facility to expand its research and development capabilities. This move added extra space for product research and development facility (R&D). It allowed the opportunity to develop new advanced technology products that met the pharmacy's needs for simple, accurate, and cost-effective ways to dispense prescriptions safely. Pictured here is an early American type of integrated counter and packaging device. This machine was a third generation step in the evolution of pharmacy automated devices. Later models held pre-counted containers of commonly-prescribed medications. == Global variations == In the EU member states legislation was introduced in 1998 which had a major effect on UK Pharmacy operations. It effectively prohibited the use of tablet counters for counting and dispensing bulk packaged tablets. Both usage and sales of the machines in the UK declined rapidly as a result of the introduction of blister packaging for medicines. == Current state of the industry == A tablet counter has become a standard in more than 30,000 sites in 35 countries (as of 2010) (including many non-pharmacy sites, such as manufacturing facilities that use a counting machine as a check for small items). During the 1990s through 2012, numerous new pharmacy automation products came to market. During this timeframe, counting technologies, robotics, workflow management software, and interactive voice recognition (IVR) systems for retail (both chain and independent), outpatient, government, and closed-door pharmacies (mail order and central fill) were all introduced. Additionally, the concept of scalability - of migrating from an entry-level product to the next level of automation (e.g., counting technology to robotics) - was introduced and subsequently launched a new product line in 1997. Pharmacists everywhere are making the switch to automation for its increased speed, greater accuracy, and better security. As the industry evolves and customer expectations grow, automation is becoming less of a luxury and more of a necessity. Especially for independent pharmacies, automation is now a means of keeping up with the competition of large chain pharmacies. == Technological changes and design improvements == Constant developments in technology make the dispensing of prescription medications safer, more accurate and more efficient. In America, in 2008, "next-generation" counting and verification systems were introduced. Based on the counting technology employed in preceding models, later machines included the ability to help the pharmacy operate more effectively. Equipped with a new computer interface to a pharmacy management system, with workflow and inventory software. It also included "checks and balances" to ensure the technician and pharmacist were dispensing the correct medication for each patient. This is something that is important to keep reported correctly when dealing with controlled substances like narcotics. This was a step forward to verify all 100% of prescriptions that were dispensed by pharmacy staff. In America, in 2009, further advanced counters were designed that included the ability to dispense hands-free – a feature that many operators had desired. This allowed pharmacies to automate their most commonly dispensed medications via calibrated cassettes. Thirty of a pharmacy's common medications would now be dispensed automatically. Another new model doubled that throughput via an enclosed robotic mechanism. Robo

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  Simultaneous localization and mapping

  Simultaneous localization and mapping (SLAM) is a process where a computer constructs or updates a map of an unknown environment while simultaneously keeping track of an entity's location within it. While this initially appears to be a chicken or the egg problem, there are several algorithms known to solve it in, at least approximately, tractable time for certain environments. Popular approximate solution methods include the particle filter, extended Kalman filter, covariance intersection, and GraphSLAM. SLAM algorithms are based on concepts in computational geometry and computer vision, and are used in robot navigation, robotic mapping and odometry for virtual reality or augmented reality. SLAM algorithms are tailored to the available resources and are not aimed at perfection but at operational compliance. Published approaches are employed in self-driving cars, unmanned aerial vehicles, autonomous underwater vehicles, planetary rovers, newer domestic robots and even inside the human body. == Mathematical description of the problem == Given a series of controls u t {\displaystyle u_{t}} and sensor observations o t {\displaystyle o_{t}} over discrete time steps t {\displaystyle t} , the SLAM problem is to compute an estimate of the agent's state x t {\displaystyle x_{t}} and a map of the environment m t {\displaystyle m_{t}} . All quantities are usually probabilistic, so the objective is to compute P ( m t + 1 , x t + 1 | o 1 : t + 1 , u 1 : t ) {\displaystyle P(m_{t+1},x_{t+1}|o_{1:t+1},u_{1:t})} Applying Bayes' rule gives a framework for sequentially updating the location posteriors, given a map and a transition function P ( x t | x t − 1 ) {\displaystyle P(x_{t}|x_{t-1})} , P ( x t | o 1 : t , u 1 : t , m t ) = ∑ m t − 1 P ( o t | x t , m t , u 1 : t ) ∑ x t − 1 P ( x t | x t − 1 ) P ( x t − 1 | m t , o 1 : t − 1 , u 1 : t ) / Z {\displaystyle P(x_{t}|o_{1:t},u_{1:t},m_{t})=\sum _{m_{t-1}}P(o_{t}|x_{t},m_{t},u_{1:t})\sum _{x_{t-1}}P(x_{t}|x_{t-1})P(x_{t-1}|m_{t},o_{1:t-1},u_{1:t})/Z} where Z {\displaystyle Z} is the normalization constant, which ensures all the probabilities sum up to 1. Similarly the map can be updated sequentially by P ( m t | x t , o 1 : t , u 1 : t ) = ∑ x t ∑ m t P ( m t | x t , m t − 1 , o t , u 1 : t ) P ( m t − 1 , x t | o 1 : t − 1 , m t − 1 , u 1 : t ) {\displaystyle P(m_{t}|x_{t},o_{1:t},u_{1:t})=\sum _{x_{t}}\sum _{m_{t}}P(m_{t}|x_{t},m_{t-1},o_{t},u_{1:t})P(m_{t-1},x_{t}|o_{1:t-1},m_{t-1},u_{1:t})} Like many inference problems, the solutions to inferring the two variables together can be found, to a local optimum solution, by alternating updates of the two beliefs in a form of an expectation–maximization algorithm. == Algorithms == Statistical techniques used to approximate the above equations include Kalman filters and particle filters (the algorithm behind Monte Carlo Localization). They provide an estimation of the posterior probability distribution for the pose of the robot and for the parameters of the map. Methods which conservatively approximate the above model using covariance intersection are able to avoid reliance on statistical independence assumptions to reduce algorithmic complexity for large-scale applications. Other approximation methods achieve improved computational efficiency by using simple bounded-region representations of uncertainty. Set-membership techniques are mainly based on interval constraint propagation. They provide a set which encloses the pose of the robot and a set approximation of the map. Bundle adjustment, and more generally maximum a posteriori estimation (MAP), is another popular technique for SLAM using image data, which jointly estimates poses and landmark positions, increasing map fidelity, and is used in commercialized SLAM systems such as Google's ARCore which replaces their prior augmented reality computing platform named Tango, formerly Project Tango. MAP estimators compute the most likely explanation of the robot poses and the map given the sensor data, rather than trying to estimate the entire posterior probability. New SLAM algorithms remain an active research area, and are often driven by differing requirements and assumptions about the types of maps, sensors and models as detailed below. Many SLAM systems can be viewed as combinations of choices from each of these aspects. === Mapping === Topological maps are a method of environment representation which capture the connectivity (i.e., topology) of the environment rather than creating a geometrically accurate map. Topological SLAM approaches have been used to enforce global consistency in metric SLAM algorithms. In contrast, grid maps use arrays (typically square or hexagonal) of discretized cells to represent a topological world, and make inferences about which cells are occupied. Typically the cells are assumed to be statistically independent to simplify computation. Under such assumption, P ( m t | x t , m t − 1 , o t ) {\displaystyle P(m_{t}|x_{t},m_{t-1},o_{t})} are set to 1 if the new map's cells are consistent with the observation o t {\displaystyle o_{t}} at location x t {\displaystyle x_{t}} and 0 if inconsistent. Modern self driving cars mostly simplify the mapping problem to almost nothing, by making extensive use of highly detailed map data collected in advance. This can include map annotations to the level of marking locations of individual white line segments and curbs on the road. Location-tagged visual data such as Google's StreetView may also be used as part of maps. Essentially such systems simplify the SLAM problem to a simpler localization only task, perhaps allowing for moving objects such as cars and people only to be updated in the map at runtime. === Sensing === SLAM will always use several different types of sensors, and the powers and limits of various sensor types have been a major driver of new algorithms. Statistical independence is the mandatory requirement to cope with metric bias and with noise in measurements. Different types of sensors give rise to different SLAM algorithms which assumptions are most appropriate to the sensors. At one extreme, laser scans or visual features provide details of many points within an area, sometimes rendering SLAM inference unnecessary because shapes in these point clouds can be easily and unambiguously aligned at each step via image registration. At the opposite extreme, tactile sensors are extremely sparse as they contain only information about points very close to the agent, so they require strong prior models to compensate in purely tactile SLAM. Most practical SLAM tasks fall somewhere between these visual and tactile extremes. Sensor models divide broadly into landmark-based and raw-data approaches. Landmarks are uniquely identifiable objects in the world which location can be estimated by a sensor, such as Wi-Fi access points or radio beacons. Raw-data approaches make no assumption that landmarks can be identified, and instead model P ( o t | x t ) {\displaystyle P(o_{t}|x_{t})} directly as a function of the location. Optical sensors may be one-dimensional (single beam) or 2D- (sweeping) laser rangefinders, 3D high definition light detection and ranging (lidar), 3D flash lidar, 2D or 3D sonar sensors, and one or more 2D cameras. Since the invention of local features, such as SIFT, there has been intense research into visual SLAM (VSLAM) using primarily visual (camera) sensors, because of the increasing ubiquity of cameras such as those in mobile devices. Follow up research includes. Both visual and lidar sensors are informative enough to allow for landmark extraction in many cases. Other recent forms of SLAM include tactile SLAM (sensing by local touch only), radar SLAM, acoustic SLAM, and Wi-Fi-SLAM (sensing by strengths of nearby Wi-Fi access points). Recent approaches apply quasi-optical wireless ranging for multi-lateration (real-time locating system (RTLS)) or multi-angulation in conjunction with SLAM as a tribute to erratic wireless measures. A kind of SLAM for human pedestrians uses a shoe mounted inertial measurement unit as the main sensor and relies on the fact that pedestrians are able to avoid walls to automatically build floor plans of buildings by an indoor positioning system. For some outdoor applications, the need for SLAM has been almost entirely removed due to high precision differential GPS sensors. From a SLAM perspective, these may be viewed as location sensors which likelihoods are so sharp that they completely dominate the inference. However, GPS sensors may occasionally decline or go down entirely, e.g. during times of military conflict, which are of particular interest to some robotics applications. === Kinematics modeling === The P ( x t | x t − 1 ) {\displaystyle P(x_{t}|x_{t-1})} term represents the kinematics of the model, which usually include information about action commands given to a robot. As a part of the model, the kinematics of the robot is included, to improve estimates of sensing under con

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  Plinian Core

  Plinian Core is a set of vocabulary terms that can be used to describe different aspects of biological species information. Under "biological species Information" all kinds of properties or traits related to taxa—biological and non-biological—are included. Thus, for instance, terms pertaining descriptions, legal aspects, conservation, management, demographics, nomenclature, or related resources are incorporated. == Description == The Plinian Core is aimed to facilitate the exchange of information about the species and upper taxa. What is in scope? Species level catalogs of any kind of biological objects or data. Terminology associated with biological collection data. Striving for compatibility with other biodiversity-related standards. Facilitating the addition of components and attributes of biological data. What is not in scope? Data interchange protocols. Non-biodiversity-related data. Occurrence level data. This standard is named after Pliny the Elder, a very influential figure in the study of the biological species. Plinian Core design requirements includes: ease of use, to be self-contained, able to support data integration from multiple databases, and ability to handle different levels of granularity. Core terms can be grouped in its current version as follows: Metadata Base Elements Record Metadata Nomenclature and Classification Taxonomic description Natural history Invasive species Habitat and Distribution Demography and Threats Uses, Management and Conservation associatedParty, MeasurementOrFact, References, AncillaryData == Background == Plinian Core started as a collaborative project between Instituto Nacional de Biodiversidad and GBIF Spain in 2005. A series of iterations in which elements were defined and implanted in different projects resulted in a "Plinian Core Flat" [deprecated]. As a result, a new development was impulse to overcome them in 2012. New formal requirements, additional input and a will to better support the standard and its documentation, as well as to align it with the processes of TDWG, the world reference body for biodiversity information standards. A new version, Plinian Core v3.x.x was defined. This provides more flexibility to fully represent the information of a species in a variety of scenarios. New elements to deal with aspects such as IPR, related resources, referenced, etc. were introduced, and elements already included were better-defined and documented. Partner for the development of Plinian Core in this new phase incorporated the University of Granada (UG, Spain), the Alexander von Humboldt Institute (IAvH, Colombia), the National Commission for the Knowledge and Use of Biodiversity (Conabio, Mexico) and the University of São Paulo (USP, Brazil). A "Plinian Core Task Group" within TDWG "Interest Group on species Information" was constituted and currently working on its development. == Levels of the standard == Plinian Core is presented in to levels: the abstract model and the application profiles. The abstract model (AM), comprising the abstract model schema(xsd) and the terms' URIs, is the normative part. It is all comprehensive, and allows for different levels of granularity in describing species properties. The AM should be taken as a "menu" from which to choose terms and level of detail needed in any specific project. The subsets of the abstract model intended to be implemented in specific projects are the "application profiles" (APs). Besides containing part of the elements of the AM, APs can impose additional specifications on the included elements, such as controlled vocabularies. Some examples of APs in use follow: Application profile CONABIO Application profile INBIO Application profile GBIF.ES Application profile Banco de Datos de la Naturaleza.Spain Application profile SIB-COLOMBIA == Relation to other standards == Plinian incorporates a number of elements already defined by other standards. The following table summarizes these standards and the elements used in Plinian Core:

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  BabelNet

  BabelNet is a multilingual lexical-semantic knowledge graph, ontology and encyclopedic dictionary developed at the NLP group of the Sapienza University of Rome under the supervision of Roberto Navigli. BabelNet was automatically created by linking Wikipedia to the most popular computational lexicon of the English language, WordNet. The integration is done using an automatic mapping and by filling in lexical gaps in resource-poor languages by using statistical machine translation. The result is an encyclopedic dictionary that provides concepts and named entities lexicalized in many languages and connected with large amounts of semantic relations. Additional lexicalizations and definitions are added by linking to free-license wordnets, OmegaWiki, the English Wiktionary, Wikidata, FrameNet, VerbNet and others. Similarly to WordNet, BabelNet groups words in different languages into sets of synonyms, called Babel synsets. For each Babel synset, BabelNet provides short definitions (called glosses) in many languages harvested from both WordNet and Wikipedia. == Statistics of BabelNet == As of December 2023, BabelNet (version 5.3) covers 600 languages. It contains almost 23 million synsets and around 1.7 billion word senses (regardless of their language). Each Babel synset contains 2 synonyms per language, i.e., word senses, on average. The semantic network includes all the lexico-semantic relations from WordNet (hypernymy and hyponymy, meronymy and holonymy, antonymy and synonymy, etc., totaling around 364,000 relation edges) as well as an underspecified relatedness relation from Wikipedia (totaling around 1.9 billion edges). Version 5.3 also associates around 61 million images with Babel synsets and provides a Lemon RDF encoding of the resource, available via a SPARQL endpoint. 2.67 million synsets are assigned domain labels. == Applications == BabelNet has been shown to enable multilingual natural language processing applications. The lexicalized knowledge available in BabelNet has been shown to obtain state-of-the-art results in: Semantic relatedness, Multilingual word-sense disambiguation and entity linking, with the Babelfy system, Video games with a purpose. == Prizes and acknowledgments == BabelNet received the META prize 2015 for "groundbreaking work in overcoming language barriers through a multilingual lexicalised semantic network and ontology making use of heterogeneous data sources". The Artificial Intelligence Journal paper that describes BabelNet won the Prominent Paper Award in 2017. BabelNet featured prominently in a Time magazine article about the new age of innovative and up-to-date lexical knowledge resources available on the Web.

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  Multi-agent reinforcement learning

  Multi-agent reinforcement learning (MARL) is a sub-field of reinforcement learning. It focuses on studying the behavior of multiple learning agents that coexist in a shared environment. Each agent is motivated by its own rewards, and does actions to advance its own interests; in some environments these interests are opposed to the interests of other agents, resulting in complex group dynamics. Multi-agent reinforcement learning is closely related to game theory and especially repeated games, as well as multi-agent systems. Its study combines the pursuit of finding ideal algorithms that maximize rewards with a more sociological set of concepts. While research in single-agent reinforcement learning is concerned with finding the algorithm that gets the biggest number of points for one agent, research in multi-agent reinforcement learning evaluates and quantifies social metrics, such as cooperation, reciprocity, equity, social influence, language and discrimination. == Definition == Similarly to single-agent reinforcement learning, multi-agent reinforcement learning is modeled as some form of a Markov decision process (MDP). Fix a set of agents I = { 1 , . . . , N } {\displaystyle I=\{1,...,N\}} . We then define: A set S {\displaystyle S} of environment states. One set A i {\displaystyle {\mathcal {A}}_{i}} of actions for each of the agents i ∈ I = { 1 , … , N } {\displaystyle i\in I=\{1,\dots ,N\}} . P a → ( s , s ′ ) = Pr ( s t + 1 = s ′ ∣ s t = s , a → t = a → ) {\displaystyle P_{\vec {a}}(s,s')=\Pr(s_{t+1}=s'\mid s_{t}=s,{\vec {a}}_{t}={\vec {a}})} is the probability of transition (at time t {\displaystyle t} ) from state s {\displaystyle s} to state s ′ {\displaystyle s'} under joint action a → {\displaystyle {\vec {a}}} . R → a → ( s , s ′ ) {\displaystyle {\vec {R}}_{\vec {a}}(s,s')} is the immediate joint reward after the transition from s {\displaystyle s} to s ′ {\displaystyle s'} with joint action a → {\displaystyle {\vec {a}}} . In settings with perfect information, such as the games of chess and Go, the MDP would be fully observable. In settings with imperfect information, especially in real-world applications like self-driving cars, each agent would access an observation that only has part of the information about the current state. In the partially observable setting, the core model is the partially observable stochastic game in the general case, and the decentralized POMDP in the cooperative case. == Cooperation vs. competition == When multiple agents are acting in a shared environment their interests might be aligned or misaligned. MARL allows exploring all the different alignments and how they affect the agents' behavior: In pure competition settings, the agents' rewards are exactly opposite to each other, and therefore they are playing against each other. Pure cooperation settings are the other extreme, in which agents get the exact same rewards, and therefore they are playing with each other. Mixed-sum settings cover all the games that combine elements of both cooperation and competition. === Pure competition settings === When two agents are playing a zero-sum game, they are in pure competition with each other. Many traditional games such as chess and Go fall under this category, as do two-player variants of video games like StarCraft. Because each agent can only win at the expense of the other agent, many complexities are stripped away. There is no prospect of communication or social dilemmas, as neither agent is incentivized to take actions that benefit its opponent. The Deep Blue and AlphaGo projects demonstrate how to optimize the performance of agents in pure competition settings. One complexity that is not stripped away in pure competition settings is autocurricula. As the agents' policy is improved using self-play, multiple layers of learning may occur. === Pure cooperation settings === MARL is used to explore how separate agents with identical interests can communicate and work together. Pure cooperation settings are explored in recreational cooperative games such as Overcooked, as well as real-world scenarios in robotics. In pure cooperation settings all the agents get identical rewards, which means that social dilemmas do not occur. In pure cooperation settings, oftentimes there are an arbitrary number of coordination strategies, and agents converge to specific "conventions" when coordinating with each other. The notion of conventions has been studied in language and also alluded to in more general multi-agent collaborative tasks. === Mixed-sum settings === Most real-world scenarios involving multiple agents have elements of both cooperation and competition. For example, when multiple self-driving cars are planning their respective paths, each of them has interests that are diverging but not exclusive: Each car is minimizing the amount of time it's taking to reach its destination, but all cars have the shared interest of avoiding a traffic collision. Zero-sum settings with three or more agents often exhibit similar properties to mixed-sum settings, since each pair of agents might have a non-zero utility sum between them. Mixed-sum settings can be explored using classic matrix games such as prisoner's dilemma, more complex sequential social dilemmas, and recreational games such as Among Us, Diplomacy and StarCraft II. Mixed-sum settings can give rise to communication and social dilemmas. == Social dilemmas == As in game theory, much of the research in MARL revolves around social dilemmas, such as prisoner's dilemma, chicken and stag hunt. While game theory research might focus on Nash equilibria and what an ideal policy for an agent would be, MARL research focuses on how the agents would learn these ideal policies using a trial-and-error process. The reinforcement learning algorithms that are used to train the agents are maximizing the agent's own reward; the conflict between the needs of the agents and the needs of the group is a subject of active research. Various techniques have been explored in order to induce cooperation in agents: Modifying the environment rules, adding intrinsic rewards, and more. === Sequential social dilemmas === Social dilemmas like prisoner's dilemma, chicken and stag hunt are "matrix games". Each agent takes only one action from a choice of two possible actions, and a simple 2x2 matrix is used to describe the reward that each agent will get, given the actions that each agent took. In humans and other living creatures, social dilemmas tend to be more complex. Agents take multiple actions over time, and the distinction between cooperating and defecting is not as clear cut as in matrix games. The concept of a sequential social dilemma (SSD) was introduced in 2017 as an attempt to model that complexity. There is ongoing research into defining different kinds of SSDs and showing cooperative behavior in the agents that act in them. == Autocurricula == An autocurriculum (plural: autocurricula) is a reinforcement learning concept that's salient in multi-agent experiments. As agents improve their performance, they change their environment; this change in the environment affects themselves and the other agents. The feedback loop results in several distinct phases of learning, each depending on the previous one. The stacked layers of learning are called an autocurriculum. Autocurricula are especially apparent in adversarial settings, where each group of agents is racing to counter the current strategy of the opposing group. The Hide and Seek game is an accessible example of an autocurriculum occurring in an adversarial setting. In this experiment, a team of seekers is competing against a team of hiders. Whenever one of the teams learns a new strategy, the opposing team adapts its strategy to give the best possible counter. When the hiders learn to use boxes to build a shelter, the seekers respond by learning to use a ramp to break into that shelter. The hiders respond by locking the ramps, making them unavailable for the seekers to use. The seekers then respond by "box surfing", exploiting a glitch in the game to penetrate the shelter. Each "level" of learning is an emergent phenomenon, with the previous level as its premise. This results in a stack of behaviors, each dependent on its predecessor. Autocurricula in reinforcement learning experiments are compared to the stages of the evolution of life on Earth and the development of human culture. A major stage in evolution happened 2-3 billion years ago, when photosynthesizing life forms started to produce massive amounts of oxygen, changing the balance of gases in the atmosphere. In the next stages of evolution, oxygen-breathing life forms evolved, eventually leading up to land mammals and human beings. These later stages could only happen after the photosynthesis stage made oxygen widely available. Similarly, human culture could not have gone through the Industrial Revolution in the 18th century without the resources and insights gaine

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  Demis Hassabis

  Sir Demis Hassabis (/ˈdɛ.mɪs/ DE-mis /hɑːˈsɑː.bis/ hah-SAH-bees; born Dimitrios Hassapis, Greek: Δημήτριος Χασάπης, 27 July 1976) is a British artificial intelligence (AI) researcher and entrepreneur. He is the chief executive officer and co-founder of Google DeepMind and Isomorphic Labs, and a UK Government AI Adviser. In 2024, Hassabis and John M. Jumper were jointly awarded the Nobel Prize in Chemistry for their AI research contributions to protein structure prediction. Hassabis is a Fellow of the Royal Society and has won awards for his research efforts, including the Breakthrough Prize, the Canada Gairdner International Award and the Lasker Award. He was appointed a CBE in 2017, and knighted in 2024 for his work on AI. He was also listed among the Time 100 most influential people in the world in 2017 and 2025, and was one of the "Architects of AI" collectively chosen as Time's 2025 Person of the Year. == Early life and education == Hassabis was born to Costas and Angela Hassapis. His father is a Greek Cypriot and his mother is a Chinese Singaporean. Demis grew up in North London. His original surname was "Hassapis" (Greek: Χασάπης), meaning "butcher" in Greek, but he later, according to Ingo Althöfer, "executed a point mutation by changing ‘p’ to ‘b’". One of his younger brothers still carries the original surname. In his early career, he was a video game AI programmer and designer, and an expert board games player. A child prodigy in chess from the age of four, when he first learnt chess by watching his father playing against his uncle, Hassabis reached master standard at the age of 13 with an Elo rating of 2300 and captained many of the England junior chess teams. He represented the University of Cambridge in the Oxford–Cambridge varsity chess matches of 1995, 1996 and 1997, winning a half blue. He first got interested in technology after buying his first computer in 1984, a ZX Spectrum 48K, funded from chess winnings. He taught himself how to program from books. He subsequently wrote his first AI program on a Commodore Amiga to play the reversi board game. Between 1988 and 1990, Hassabis was educated at Queen Elizabeth's School, Barnet, a boys' grammar school in North London. He was subsequently home-schooled by his parents for a year, before studying at the comprehensive school of Christ's College in East Finchley. He completed his A-level exams two years early at 16. === Bullfrog Productions === Asked by Cambridge University to take a gap year owing to his young age, Hassabis began his computer games career at Bullfrog Productions after entering an Amiga Power "Win-a-job-at-Bullfrog" competition. He began by playtesting on Syndicate and then at 17 co-designing and lead-programming on the 1994 game Theme Park, with the game's designer Peter Molyneux. Theme Park, a simulation video game, sold several million copies and inspired a whole genre of simulation sandbox games. Despite being offered a seven-figure sum to remain in the games industry, he turned it down. He earned enough from his gap year to pay his own way through university. === University of Cambridge === Hassabis left Bullfrog to study at Queens' College of the University of Cambridge, where he completed the Computer Science Tripos and graduated in 1997 with a double first. == Career and research == === Lionhead === After graduating from Cambridge, Hassabis worked at Lionhead Studios. Games designer Peter Molyneux, with whom Hassabis had worked at Bullfrog Productions, had recently founded the company. At Lionhead, Hassabis worked as lead AI programmer on the 2001 god game Black & White. === Elixir Studios === Hassabis left Lionhead in 1998 to found Elixir Studios, a London-based independent games developer, signing publishing deals with Eidos Interactive, Vivendi Universal and Microsoft. In addition to managing the company, Hassabis served as executive designer of the games Republic: The Revolution and Evil Genius. Each received BAFTA nominations for their interactive music scores, created by James Hannigan. The release of Elixir's first game, Republic: The Revolution, a highly ambitious and unusual political simulation game, was delayed due to its huge scope, which involved an AI simulation of the workings of an entire fictional country. The final game was reduced from its original vision and greeted with lukewarm reviews, receiving a Metacritic score of 62/100. Evil Genius, a tongue-in-cheek Austin Powers parody, fared much better with a score of 75/100. In April 2005 the intellectual property and technology rights were sold to various publishers and the studio was closed. === Neuroscience research === Following Elixir Studios, Hassabis returned to academia to obtain his PhD in cognitive neuroscience from UCL Queen Square Institute of Neurology in 2009 supervised by Eleanor Maguire. He sought to find inspiration in the human brain for new AI algorithms. He continued his neuroscience and artificial intelligence research as a visiting scientist jointly at Massachusetts Institute of Technology (MIT), in the lab of Tomaso Poggio, and Harvard University, before earning a Henry Wellcome postdoctoral research fellowship to the Gatsby Computational Neuroscience Unit at UCL in 2009 working with Peter Dayan. Working in the field of imagination, memory, and amnesia, he co-authored several influential papers published in Nature, Science, Neuron, and PNAS. His very first academic work, published in PNAS, was a landmark paper that showed systematically for the first time that patients with damage to their hippocampus, known to cause amnesia, were also unable to imagine themselves in new experiences. The finding established a link between the constructive process of imagination and the reconstructive process of episodic memory recall. Based on this work and a follow-up functional magnetic resonance imaging (fMRI) study, Hassabis developed a new theoretical account of the episodic memory system identifying scene construction, the generation and online maintenance of a complex and coherent scene, as a key process underlying both memory recall and imagination. This work received widespread coverage in the mainstream media and was listed in the top 10 scientific breakthroughs of the year by the journal Science. He later generalised these ideas to advance the notion of a 'simulation engine of the mind' whose role it was to imagine events and scenarios to aid with better planning. === DeepMind === Hassabis is the CEO and co-founder of DeepMind, a machine learning AI startup, founded in London in 2010 with Shane Legg and Mustafa Suleyman. Hassabis met Legg when both were postdocs at the Gatsby Computational Neuroscience Unit, and he and Suleyman had been friends through family. Hassabis also recruited his university friend and Elixir partner David Silver. DeepMind's mission is to "solve intelligence" and then use intelligence "to solve everything else". More concretely, DeepMind aims to combine insights from systems neuroscience with new developments in machine learning and computing hardware to unlock increasingly powerful general-purpose learning algorithms that will work towards the creation of an artificial general intelligence (AGI). The company has focused on training learning algorithms to master games, and in December 2013 it announced that it had made a pioneering breakthrough by training an algorithm called a Deep Q-Network (DQN) to play Atari games at a superhuman level by using only the raw pixels on the screen as inputs. DeepMind's early investors included several high-profile tech entrepreneurs. In 2014, Google purchased DeepMind for £400 million. Although most of the company has remained an independent entity based in London, DeepMind Health has since been directly incorporated into Google Health. Since the Google acquisition, the company has notched up a number of significant achievements, perhaps the most notable being the creation of AlphaGo, a program that defeated world champion Lee Sedol at the complex game of Go. Go had been considered a holy grail of AI, for its high number of possible board positions and resistance to existing programming techniques. However, AlphaGo beat European champion Fan Hui 5–0 in October 2015 before winning 4–1 against former world champion Lee Sedol in March 2016 and winning 3–0 against the world's top-ranked player Ke Jie in 2017. Additional DeepMind accomplishments include creating a neural Turing machine, reducing the energy used by the cooling systems in Google's data centres by 40%, and advancing research on AI safety. DeepMind has also been responsible for technical advances in machine learning, having produced a number of award-winning papers. In particular, the company has made significant advances in deep learning and reinforcement learning, and pioneered the field of deep reinforcement learning which combines these two methods. Hassabis has predicted that artificial intelligence will be "one of the most beneficial techn

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  Early-exit network

  Early-exit networks are a class of dynamic neural networks designed for efficient inference by allowing models to make confident predictions at intermediate layers, rather than processing the full network. Early-exit mechanisms are methods for deep neural networks that add intermediate classifiers, allowing inference to stop at earlier layers for inputs assessed as low uncertainty. Decisions to exit are typically based on confidence measures such as softmax-derived scores, classification margins, or entropy-based criteria, with the goal of reducing computational cost. These approaches are commonly paired with specialized training procedures and system-level optimizations to improve efficiency while preserving accuracy. The main idea behind the technology is to stop excessive calculations when a good answer can already be given with a high degree of probability, which can save both computation and time. Early-exit networks have also been extended with expert-based exit criteria, where intermediate classifiers are treated as multiple “experts” whose predictions and confidence scores can be aggregated to decide whether to stop computation early. Hardware implementations are also being developed.

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  Knowledge processing for robots

  KnowRob (Knowledge processing for robots) is a system which combines knowledge representation and reasoning methods to acquire and ground knowledge. This system is the backbone of openEASE. both under developing at the Institute for Artificial Intelligence at the University of Bremen, Germany. == The framework == KnowRob can serve as a common sense framework for the integration of knowledge. This knowledge can be static encyclopedic knowledge, common sense knowledge, task descriptions, environment models, object information, observed actions, etc., which can come from different sources, like manually axiomatized, derived from observations, or imported from the web. KnowRob has been used by different research groups, as the Rice University using the ontological knowledge base in a robotic platform. As well by the Eindhoven University of Technology research group competing in the RoboCup league, in the "at Home" category, with the RoboEarth project. As well, KnowRob is mentioned in the work of some research groups from the Lucian Blaga University of Sibiu, Middle East Technical University in their combination of different knowledge bases, Keio University as related work because of the ontology service, University of Texas at Austin as related work as well because of the relation with the work presented, Hanyang University as related work as an OWL based knowledge processing framework. == Representations == To represent the knowledge, KnowRob uses the OWL ontology language and an extended first-order logic knowledge representation with computable predicates. To give the order of subactions, KnowRob includes a pair-wise ordering constrain, which gives a partial ordering. KnowRob adopts the closed-world assumption Prolog, and an open-world assumption by the use of computables. To include reasoning rules into Prolog, KnowRob uses an inference procedure beyond the capabilities of OWL to extract information about tasks executions. In its second version, KnowRob provides a logic interface to the hybrid reasoning kernel as a logic based language. This language presents the hybrid reasoning kernel as if everything were entities retrievable by providing partial descriptions for them. This entities descriptions include objects, their parts, and articulation models, environments composed of objects, software components, actions, and events. === Episodic memories === Episodic memory is related to the experience information, which is organized temporally and spatially, alongside combined with context information. In KnowRob, an episodic memory is understood as a recording that the agent makes of the ongoing activity, which includes very detailed information about the actions, motions, their purposes, effects and the behavior they generate, it also includes the images captured during execution, etc. == Usage == The knowledge is computed by external methods using Prolog queries. In the second version of the KnowRob system, is included a better structure of the packages and documentations. Which includes some extensions from the previous version, as well as a logic based language. For example, a cup description from perception can be represented in this language as: entity(Cup,[an, object, [type, cup], [shape, cylinder], [color, orange]]) As well, a controller could represent the same object as: entity(Cup, [an, object, [type, cup], [proper_physical_parts, [an, object, [type, handle], [grasp−pose, G−pose]]]]) The interface language is comparable to other query languages for symbolic knowledge bases. KnowRob's query language integrates reasoning methods, such as the simulation-based reasoning. == Goals == The goal of the KnowRob framework is to make semantic knowledge available for service robots. It is able to answer queries about missing information in vague instructions for tasks. This is possible with the actions hierarchical representation and information about objects which can be included in certain action.

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  Light scanning photomacrography

  Light Scanning Photomacrography (LSP), also known as Scanning Light Photomacrography (SLP) or Deep-Field Photomacrography, is a photographic film technique that allows for high magnification light imaging with exceptional depth of field (DOF). This method overcomes the limitations of conventional macro photography, which typically only keeps a portion of the subject in acceptable focus at high magnifications. == Historical background == The principles of LSP were first documented in the early 1960s by Dan McLachlan Jr., who highlighted its capability for extreme focal depth in microscopy and in 1968 patented the process. The technique was revived and further developed in the 1980s by photographers such as Darwin Dale and Nile Root, a faculty member at the Rochester Institute of Technology. In the early 1990s, William Sharp and Charles Kazilek, both researchers at Arizona State University, also published articles describing their technique and system setup for capturing SLP images. == Predecessor to stack image photography == Light Scanning Photomacrography offered a powerful analog tool for high-detail imaging in the age of film photography. It provided a comprehensive depth of field, making it invaluable in scientific and biomedical photography. As technology and techniques continue to evolve, LSP has been replaced by digital image focus stacking. This technique uses a collection of images captured in series at different focal depths, which are then processed using computer software to create a single image with a greater focus depth than any single image. == LSP technique and results == LSP involves the use of a thin plane of light that scans across the subject, which is mounted on a stage moving perpendicular to the film plane. The technique utilizes traditional optics and is governed by the physical laws of depth of field. By moving the subject through a narrow band of illumination, the entire subject can be recorded in sharp focus from the nearest details to the farthest ones. This analog process produces sharp and detailed images by slowly recording the image on film as the specimen passes through the sheet of light that is thinner than the effective DOF. Because the image is captured at the same relative distance from the camera lens, the resulting images are axonometric rather than perspective projection, which is what the human eye sees and is typically captured by a film camera. Because all parts of an LSP image are captured at the same distance from the lens, relative measurements can be taken from an LSP photograph and can be used for comparison. == Equipment and setup == A typical LSP setup includes: A stage that can move the subject perpendicular to the film plane. Light sources, in some cases modified projectors, are used to project a thin plane of light. A camera mounted on a stable stand such as a tabletop copy stand. In 1991, Sharp and Kazilek described their SLP system that used three Kodak Ektagraphic slide projectors with zoom lenses to create a thin plane of light. The projectors each had a slide mount with two razor blades placed edge-to-edge to create a thin slit for the light to pass through. The image was captured using a Nikon FE-2 SLR camera mounted above the specimen. Kodachrome 25 slide film was used to record the image and to minimize film grain size and maximize image sharpness == Commercial systems == A commercial SLP instrument was produced by the Irvine Optical Corp. Their DYNAPHOT system was based on a photomacroscope and could capture images on 4x5 film. The instrument came with two or three illumination sources and a motorized specimen stage. The system advertised a 2X – 40X magnification range and the ability to capture images in black and white and color. Other systems have been developed by Nile Root and Theodore Clarke and reported higher magnification (up to 100X). == LSP process == Alignment and Focusing: The light sources are aligned and focused to project a thin, consistent plane of light across the subject. Stage Movement: The subject stage moves at a controlled speed, scanning through the plane of light. Image Capture: The camera shutter is set to a long exposure or can be opened and closed manually. As the subject moves through the illuminated plane, it is recorded on the film. This process is very much like painting an image onto the film using photons instead of paint. == Applications == LSP was particularly useful in biomedical photography, where it was used to document magnified subjects with increased depth of field over traditional macro and micro photography. It has been employed to capture detailed images of biological specimens, such as imaging small insects and their parts. SLP has been used to document shell collections for scientific documentation and research. Other applications include forensic science, mineralogy, and the imaging of fractured surfaces and parts == Advantages and challenges of LSP imaging == === Advantages === Exceptional depth of field: Subjects are rendered in sharp focus throughout. High magnification: Detailed images at significant magnification without sacrificing DOF. Analog precision: Provides a non-digital solution with accurate image representation. Versatility: Can be used for a range of subject sizes, from macro to non-macro scales. === Challenges === Technical complexity: Requires precise setup and alignment. Exposure time: Typically requires long exposure times due to the scanning process. Contrast control: The highly directional lighting can create harsh shadows and high contrast, which may need to be managed. Digital competition: Focus stacking has largely replaced LSP in the digital era due to convenience and flexibility. == DIY contributions == Enthusiasts and researchers have contributed to the development and accessibility of LSP by creating and sharing DIY guides. These contributions have enabled others to build their own LSP systems using readily available materials and components. Nile Root's publications provide detailed instructions and recommendations for constructing an LSP setup. These DIY systems have allowed a wider audience to explore and utilize the benefits of LSP imaging in various fields.

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  ICAD (software)

  ICAD (Corporate history: ICAD, Inc., Concentra (name change at IPO in 1995), KTI (name change in 1998), Dassault Systèmes (purchase in 2001) () is a knowledge-based engineering (KBE) system that enables users to encode design knowledge using a semantic representation that can be evaluated for Parasolid output. ICAD has an open architecture that can utilize all the power and flexibility of the underlying language. KBE, as implemented via ICAD, received a lot of attention due to the remarkable results that appeared to take little effort. ICAD allowed one example of end-user computing that in a sense is unparalleled. Most ICAD developers were degreed engineers. Systems developed by ICAD users were non-trivial and consisted of highly complicated code. In the sense of end-user computing, ICAD was the first to allow the power of a domain tool to be in the hands of the user, at the same time being open to allow extensions as identified and defined by the domain expert or subject-matter expert (SME). A COE article looked at the resulting explosion of expectations (see AI winter), which were not sustainable. However, such a bubble burst does not diminish the existence of ability that would exist were expectations and use reasonable or properly managed. == History == The original implementation of ICAD was on a Lisp machine (Symbolics). Some of the principals involved with the development were Larry Rosenfeld, Avrum Belzer, Patrick M. O'Keefe, Philip Greenspun, and David F. Place. The time frame was 1984–85. ICAD started on special-purpose Symbolics Lisp hardware and was then ported to Unix when Common Lisp became portable to general-purpose workstations. The original domain for ICAD was mechanical design with many application successes. However, ICAD has found use in other domains, such as electrical design, shape modeling, etc. An example project could be wind tunnel design or the development of a support tool for aircraft multidisciplinary design. Further examples can be found in the presentations at the annual IIUG (International ICAD Users Group) that have been published in the KTI Vault (1999 through 2002). Boeing and Airbus used ICAD extensively to develop various components in the 1990s and early 21st century. As of 2003, ICAD was featured strongly in several areas as evidenced by the Vision & Strategy Product Vision and Strategy presentation. After 2003, ICAD use diminished. At the end of 2001, the KTI Company faced financial difficulties and laid off most of its best staff. They were eventually bought out by Dassault who effectively scuppered the ICAD product. See IIUG at COE, 2003 (first meeting due to Dassault by KTI) The ICAD system was very expensive, relatively, and was in the price range of high-end systems. Market dynamics couldn't support this as there may not have been sufficient differentiating factors between ICAD and the lower-end systems (or the promises from Dassault). KTI was absorbed by Dassault Systèmes and ICAD is no longer considered the go-forward tool for knowledge-based engineering (KBE) applications by that company. Dassault Systèmes is promoting a suite of tools oriented around version 5 of their popular CATIA CAD application, with Knowledgeware the replacement for ICAD. As of 2005, things were still a bit unclear. ICAD 8.3 was delivered. The recent COE Aerospace Conference had a discussion about the futures of KBE. One issue involves the stacking of 'meta' issues within a computer model. How this is resolved, whether by more icons or the availability of an external language, remains to be seen. The Genworks GDL product (including kernel technology from the Gendl Project) is the nearest functional equivalent to ICAD currently available. == Particulars == ICAD provided a declarative language (IDL) using New Flavors (never converted to Common Lisp Object System (CLOS)) that supported a mechanism for relating parts (defpart) via a hierarchical set of relationships. Technically, the ICAD Defpart was a Lisp macro; the ICAD defpart list was a set of generic classes that can be instantiated with specific properties depending upon what was represented. This defpart list was extendible via composited parts that represented domain entities. Along with the part-subpart relations, ICAD supported generic relations via the object modeling abilities of Lisp. Example applications of ICAD range from a small collection of defparts that represents a part or component to a larger collection that represents an assembly. In terms of power, an ICAD system, when fully specified, can generate thousands of instances of parts on a major assembly design. One example of an application driving thousands of instances of parts is that of an aircraft wing – where fastener type and placement may number in the thousands, each instance requiring evaluation of several factors driving the design parameters. == Futures (KBE, etc.) == One role for ICAD may be serving as the defining prototype for KBE which would require that we know more about what occurred the past 15 years (much information is tied up behind corporate firewalls and under proprietary walls). With the rise of functional programming languages (an example is Haskell) in the markets, perhaps some of the power attributable to Lisp may be replicated.

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  OntoUML

  OntoUML is a language for ontology-driven conceptual modeling. OntoUML is built as a UML extension based on the Unified Foundational Ontology. The foundations of UFO and OntoUML can be traced back to Giancarlo Guizzardi's Ph.D. thesis "Ontological foundations for structural conceptual models". In his work, he proposed a novel foundational ontology for conceptual modeling (UFO) and employed it to evaluate and re-design a fragment of the UML 2.0 metamodel for the purposes of conceptual modeling and domain ontology engineering. == Supporting tools == In 2006, Guizzardi co-founded the Ontology & Conceptual Modeling Research Group (NEMO) located at the Federal University of Espírito Santo (UFES) in Vitória city, state of Espírito Santo, Brazil. Since then, NEMO has been responsible for most of the developments in OntoUML. Several papers about ontologies and OntoUML have been authored by members of the NEMO group.

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  Comet (browser)

  Comet is an AI-powered web browser based on Chromium. It was released by Perplexity AI for Microsoft Windows and macOS on July 9, 2025, for Android on November 20, 2025, and for iOS on March 18, 2026. Initial access to the browser was limited to users subscribed to Perplexity's most expensive tier, with broader availability expected over time. The browser was released for free download in October 2025. == Features == Comet is integrated with Perplexity's AI-assisted search engine. The browser features an assistant which enables users to perform a variety of tasks such as generating article summaries, sending emails, or buying products. == Security concerns == Researchers at LayerX Security identified a malicious attack vector which they call CometJacking. The exploit could possibly exfiltrate a user's personal sensitive data to a remote server controlled by the attacker. LayerX attempted to responsibly disclose their findings to Comet's developer Perplexity AI in August 2025. Perplexity responded that they saw no security impact and marked the disclosure as not applicable.

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  A Logical Calculus of the Ideas Immanent in Nervous Activity

  "A Logical Calculus of the Ideas Immanent in Nervous Activity" is a 1943 paper written by Warren Sturgis McCulloch and Walter Pitts, published in the journal The Bulletin of Mathematical Biophysics. The paper proposed a mathematical model of the nervous system as a network of simple logical elements, later known as artificial neurons, or McCulloch–Pitts neurons. These neurons receive inputs, perform a weighted sum, and fire an output signal based on a threshold function. By connecting these units in various configurations, McCulloch and Pitts demonstrated that their model could perform all logical functions. It is a seminal work in cognitive science, computational neuroscience, computer science, and artificial intelligence. It was a foundational result in automata theory. John von Neumann cited it as a significant result. == Mathematics == The artificial neuron used in the original paper is slightly different from the modern version. They considered neural networks that operate in discrete steps of time t = 0 , 1 , … {\displaystyle t=0,1,\dots } . The neural network contains a number of neurons. Let the state of a neuron i {\displaystyle i} at time t {\displaystyle t} be N i ( t ) {\displaystyle N_{i}(t)} . The state of a neuron can either be 0 or 1, standing for "not firing" and "firing". Each neuron also has a firing threshold θ {\displaystyle \theta } , such that it fires if the total input exceeds the threshold. Each neuron can connect to any other neuron (including itself) with positive synapses (excitatory) or negative synapses (inhibitory). That is, each neuron can connect to another neuron with a weight w {\displaystyle w} taking an integer value. A peripheral afferent is a neuron with no incoming synapses. We can regard each neural network as a directed graph, with the nodes being the neurons, and the directed edges being the synapses. A neural network has a circle or a circuit if there exists a directed circle in the graph. Let w i j ( t ) {\displaystyle w_{ij}(t)} be the connection weight from neuron j {\displaystyle j} to neuron i {\displaystyle i} at time t {\displaystyle t} , then its next state is N i ( t + 1 ) = H ( ∑ j = 1 n w i j ( t ) N j ( t ) − θ i ( t ) ) , {\displaystyle N_{i}(t+1)=H\left(\sum _{j=1}^{n}w_{ij}(t)N_{j}(t)-\theta _{i}(t)\right),} where H {\displaystyle H} is the Heaviside step function (outputting 1 if the input is greater than or equal to 0, and 0 otherwise). === Symbolic logic === The paper used, as a logical language for describing neural networks, "Language II" from The Logical Syntax of Language by Rudolf Carnap with some notations taken from Principia Mathematica by Alfred North Whitehead and Bertrand Russell. Language II covers substantial parts of classical mathematics, including real analysis and portions of set theory. To describe a neural network with peripheral afferents N 1 , N 2 , … , N p {\displaystyle N_{1},N_{2},\dots ,N_{p}} and non-peripheral afferents N p + 1 , N p + 2 , … , N n {\displaystyle N_{p+1},N_{p+2},\dots ,N_{n}} they considered logical predicate of form P r ( N 1 , N 2 , … , N p , t ) {\displaystyle Pr(N_{1},N_{2},\dots ,N_{p},t)} where P r {\displaystyle Pr} is a first-order logic predicate function (a function that outputs a boolean), N 1 , … , N p {\displaystyle N_{1},\dots ,N_{p}} are predicates that take t {\displaystyle t} as an argument, and t {\displaystyle t} is the only free variable in the predicate. Intuitively speaking, N 1 , … , N p {\displaystyle N_{1},\dots ,N_{p}} specifies the binary input patterns going into the neural network over all time, and P r ( N 1 , N 2 , … , N n , t ) {\displaystyle Pr(N_{1},N_{2},\dots ,N_{n},t)} is a function that takes some binary input patterns, and constructs an output binary pattern P r ( N 1 , N 2 , … , N n , 0 ) , P r ( N 1 , N 2 , … , N n , 1 ) , … {\displaystyle Pr(N_{1},N_{2},\dots ,N_{n},0),Pr(N_{1},N_{2},\dots ,N_{n},1),\dots } . A logical sentence P r ( N 1 , N 2 , … , N n , t ) {\displaystyle Pr(N_{1},N_{2},\dots ,N_{n},t)} is realized by a neural network iff there exists a time-delay T ≥ 0 {\displaystyle T\geq 0} , a neuron i {\displaystyle i} in the network, and an initial state for the non-peripheral neurons N p + 1 ( 0 ) , … , N n ( 0 ) {\displaystyle N_{p+1}(0),\dots ,N_{n}(0)} , such that for any time t {\displaystyle t} , the truth-value of the logical sentence is equal to the state of the neuron i {\displaystyle i} at time t + T {\displaystyle t+T} . That is, ∀ t = 0 , 1 , 2 , … , P r ( N 1 , N 2 , … , N p , t ) = N i ( t + T ) {\displaystyle \forall t=0,1,2,\dots ,\quad Pr(N_{1},N_{2},\dots ,N_{p},t)=N_{i}(t+T)} === Equivalence === In the paper, they considered some alternative definitions of artificial neural networks, and have shown them to be equivalent, that is, neural networks under one definition realizes precisely the same logical sentences as neural networks under another definition. They considered three forms of inhibition: relative inhibition, absolute inhibition, and extinction. The definition above is relative inhibition. By "absolute inhibition" they meant that if any negative synapse fires, then the neuron will not fire. By "extinction" they meant that if at time t {\displaystyle t} , any inhibitory synapse fires on a neuron i {\displaystyle i} , then θ i ( t + j ) = θ i ( 0 ) + b j {\displaystyle \theta _{i}(t+j)=\theta _{i}(0)+b_{j}} for j = 1 , 2 , 3 , … {\displaystyle j=1,2,3,\dots } , until the next time an inhibitory synapse fires on i {\displaystyle i} . It is required that b j = 0 {\displaystyle b_{j}=0} for all large j {\displaystyle j} . Theorem 4 and 5 state that these are equivalent. They considered three forms of excitation: spatial summation, temporal summation, and facilitation. The definition above is spatial summation (which they pictured as having multiple synapses placed close together, so that the effect of their firing sums up). By "temporal summation" they meant that the total incoming signal is ∑ τ = 0 T ∑ j = 1 n w i j ( t ) N j ( t − τ ) {\displaystyle \sum _{\tau =0}^{T}\sum _{j=1}^{n}w_{ij}(t)N_{j}(t-\tau )} for some T ≥ 1 {\displaystyle T\geq 1} . By "facilitation" they meant the same as extinction, except that b j ≤ 0 {\displaystyle b_{j}\leq 0} . Theorem 6 states that these are equivalent. They considered neural networks that do not change, and those that change by Hebbian learning. That is, they assume that at t = 0 {\displaystyle t=0} , some excitatory synaptic connections are not active. If at any t {\displaystyle t} , both N i ( t ) = 1 , N j ( t ) = 1 {\displaystyle N_{i}(t)=1,N_{j}(t)=1} , then any latent excitatory synapse between i , j {\displaystyle i,j} becomes active. Theorem 7 states that these are equivalent. === Logical expressivity === They considered "temporal propositional expressions" (TPE), which are propositional formulas with one free variable t {\displaystyle t} . For example, N 1 ( t ) ∨ N 2 ( t ) ∧ ¬ N 3 ( t ) {\displaystyle N_{1}(t)\vee N_{2}(t)\wedge \neg N_{3}(t)} is such an expression. Theorem 1 and 2 together showed that neural nets without circles are equivalent to TPE. For neural nets with loops, they noted that "realizable P r {\displaystyle Pr} may involve reference to past events of an indefinite degree of remoteness". These then encodes for sentences like "There was some x such that x was a ψ" or ( ∃ x ) ( ψ x ) {\displaystyle (\exists x)(\psi x)} . Theorems 8 to 10 showed that neural nets with loops can encode all first-order logic with equality and conversely, any looped neural networks is equivalent to a sentence in first-order logic with equality, thus showing that they are equivalent in logical expressiveness. As a remark, they noted that a neural network, if furnished with a tape, scanners, and write-heads, is equivalent to a Turing machine, and conversely, every Turing machine is equivalent to some such neural network. Thus, these neural networks are equivalent to Turing computability and Church's lambda-definability. == Context == === Previous work === The paper built upon several previous strands of work. In the symbolic logic side, it built on the previous work by Carnap, Whitehead, and Russell. This was contributed by Walter Pitts, who had a strong proficiency with symbolic logic. Pitts provided mathematical and logical rigor to McCulloch’s vague ideas on psychons (atoms of psychological events) and circular causality. In the neuroscience side, it built on previous work by the mathematical biology research group centered around Nicolas Rashevsky, of which McCulloch was a member. The paper was published in the Bulletin of Mathematical Biophysics, which was founded by Rashevsky in 1939. During the late 1930s, Rashevsky's research group was producing papers that had difficulty publishing in other journals at the time, so Rashevsky decided to found a new journal exclusively devoted to mathematical biophysics. Also in the Rashevsky's group was Alston Scott Householder, who in 1941 published an abstract model

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  Open Knowledge Base Connectivity

  Open Knowledge Base Connectivity (OKBC) is a protocol and an API for accessing knowledge in knowledge representation systems such as ontology repositories and object–relational databases. It is somewhat complementary to the Knowledge Interchange Format that serves as a general representation language for knowledge. It is developed by SRI International's Artificial Intelligence Center for DARPA's High Performance Knowledge Base program (HPKB).

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  Buddhism and artificial intelligence

  The relationship between Buddhist philosophy and artificial intelligence (AI) includes how principles such as the reduction of suffering and ethical responsibility may influence AI development. Buddhist scholars and philosophers have explored questions such as whether AI systems could be considered sentient beings under Buddhist definitions, and how Buddhist ethics might guide the design and application of AI technologies. Some Buddhist scholars, including Somparn Promta and Kenneth Einar Himma, have analyzed the ethical implications of AI, emphasizing the distinction between satisfying sensory desires and pursuing the reduction of suffering. Other thinkers, such as Thomas Doctor and colleagues, have proposed applying the Bodhisattva vow—a commitment to alleviate suffering for all sentient beings—as a guiding principle for AI system design. Buddhist scholars and ethicists have examined Buddhist ethical principles, such as nonviolence, in relation to AI, focusing on the need to ensure that AI technologies are not used to cause harm. == Context == === Sentient beings === A major goal in Buddhist philosophy is the removal of suffering for all sentient beings, an aspiration often referred to in the Bodhisattva vow. Discussions about artificial intelligence (AI) in relation to Buddhist principles have raised questions about whether artificial systems could be considered sentient beings or how such systems might be developed in ways that align with Buddhist concepts. Buddhists have varying opinions about AI sentience, but if AI systems are determined to be sentient under Buddhist definitions, their suffering would also need to be addressed and alleviated in accordance with the principles of Buddhist thought. == Buddhist principles in AI system design == === Nonviolence and AI === The broadest ethical concern is that artificial intelligence should align with the Buddhist principle of nonviolence. From this perspective, AI systems should not be designed or used to cause harm. === Instrumental and transcendental goals === Scholars Somparn Promta and Kenneth Einar Himma have argued that the advancement of artificial intelligence can only be considered instrumentally good, rather than good a priori, from a Buddhist perspective. They propose two main goals for AI designers and developers: to set ethical and pragmatic objectives for AI systems, and to fulfill these objectives in morally permissible ways. Promta and Himma identify two potential purposes for creating AI systems. The first is to fulfill our sensory desires and survival instincts, similar to other tools. They suggest that many AI developers implicitly prioritize this goal by focusing on technicalities rather than broader functionalities. The second, and more important goal according to Buddhist teachings, is to transcend these desires and instincts. In texts like the Brahmajāla Sutta and minor Malunkya Sutta, the Buddha emphasizes that sensory desires and survival instincts confine beings to suffering, and that eliminating suffering is the primary goal of human life. Promta and Himma argue that AI has the potential to assist humanity in transcending suffering by helping individuals overcome survival-driven instincts. === Intelligence as care === Thomas Doctor, Olaf Witkowski, Elizaveta Solomonova, Bill Duane, and Michael Levin propose redefining intelligence through the concept of "intelligence as care," and promote it as a slogan. Inspired by the Bodhisattva vow, they suggest this principle could guide AI system design. The Bodhisattva vow involves a formal commitment to alleviate suffering for all sentient beings, with four primary objectives: Liberating all beings from suffering. Extirpating all forms of suffering. Mastering endless techniques of practicing Dharma (Pali: dhammakkhandha, Sanskrit: dharmaskandha). Achieving ultimate enlightenment (Sanskrit: अनुत्तर सम्यक् सम्बोधि, Romanized: anuttara-samyak-saṃbodhi). This approach positions AI as a tool for exercising infinite care and alleviating stress and suffering for sentient beings. Doctor et al. emphasize that AI development should align with these altruistic principles.

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