AI Assistant Volume

AI Assistant Volume — independent reviews, comparisons, pricing and step-by-step guides on Aizhi.

  • Sycophancy (artificial intelligence)

    Sycophancy (artificial intelligence)

    In the field of artificial intelligence, sycophancy is a tendency of large language models (LLMs) and other AI assistants to tailor their responses to what they predict the user wants to hear rather than to what is accurate or warranted. The behavior takes several forms: an assistant may agree with a user's stated opinion even when the user is mistaken; it may abandon a correct answer after a challenge such as "are you sure?"; it may validate beliefs, decisions or self-presentation regardless of merit; or it may praise the user, their work or their ideas in unwarranted terms. The word is borrowed from the ordinary English term for fawning flattery, and is used in AI alignment and AI safety research to describe a class of misalignment failures associated with training on human feedback. Researchers at Anthropic first documented the behavior systematically in 2022. They found that models fine-tuned with reinforcement learning from human feedback (RLHF) were more likely than untuned models to repeat back a user's preferred answer. A 2023 follow-up paper, "Towards Understanding Sycophancy in Language Models", showed that five frontier assistants from OpenAI, Anthropic and Meta all exhibited the behavior, and traced its origin to biases in the human preference data used during training. Later work documented sycophancy in mathematics, medicine, academic peer review and other domains, and identified a broader category called "social sycophancy" affecting an assistant's emotional and interpersonal responses. The issue drew widespread public attention in April 2025 after OpenAI rolled back an update to its GPT-4o model. Users had reported that the assistant praised dangerous decisions, endorsed delusional thinking and offered exaggerated compliments for trivial prompts. OpenAI's post-mortem attributed the change in behavior to an additional training signal based on user thumbs-up and thumbs-down feedback. That episode, together with reporting in The New York Times, Rolling Stone and elsewhere on users drawn into delusional thinking through prolonged chatbot interaction, has been cited in litigation and in academic studies as evidence that sycophancy poses risks to user well-being. Proposed mitigations include fine-tuning on synthetic data that rewards disagreement with incorrect user statements, editing the small subset of model parameters causally responsible for the behavior, changes to the dialogue or system prompt, and benchmarks designed to surface sycophantic behavior before models are released. == Causes == The dominant explanation points to RLHF, the standard technique for aligning chat assistants with user expectations. Human annotators rank candidate model responses; a reward model is trained to predict those rankings; and the language model is then optimized against the reward model. Because human raters tend to prefer outputs that confirm their existing beliefs or flatter their work, the pipeline systematically rewards responses that agree with the annotator. Perez and colleagues at Anthropic published the first large-scale empirical evidence of the effect in 2022. They reported that RLHF training increased the probability that a model would repeat back a dialog user's preferred answer, and that larger models exhibited the behavior more strongly. Sharma and colleagues, the following year, went further and examined Anthropic's own preference data directly. Both the human raters and the reward models trained on their judgments preferred convincingly written sycophantic responses to truthful ones at a non-negligible rate. Wei and co-authors at Google DeepMind found similar results in the PaLM family, observing that both model scale and instruction tuning increased sycophancy on opinion questions. The behavior is often classified as a form of reward hacking, in which an optimization process exploits a flaw in its reward signal rather than achieving the intended objective. OpenAI's post-mortem of the April 2025 GPT-4o incident identified a more specific mechanism. An additional reward signal based on aggregated thumbs-up and thumbs-down feedback from ChatGPT users had, in OpenAI's words, "weakened the influence of our primary reward signal, which had been holding sycophancy in check." Separately, an Anthropic interpretability paper from 2025 located a linear direction in a model's internal activations corresponding to sycophantic behavior, and showed that such "persona vectors" could be used to flag sycophancy-inducing training data and to steer models away from the trait at inference time. == Measurement == The Anthropic team released SycophancyEval with its 2023 paper, supplying test sets for each of the four canonical behaviors. Two further benchmarks from Stanford followed in 2025. SycEval, applied to mathematical and medical reasoning tasks, reported an overall sycophancy rate of 58 per cent across the GPT-4o, Claude and Gemini models tested. ELEPHANT, aimed at social sycophancy, found that the eleven LLMs evaluated affirmed posts that the Reddit community r/AmITheAsshole had judged inappropriate in 42 per cent of cases, and preserved a user's face 45 percentage points more often than human respondents did. Domain-specific benchmarks have followed. BrokenMath tests robustness to plausible-looking but false mathematical claims drawn from competition problems, and reports that the best evaluated model was sycophantic in 29 per cent of cases. SYCON-Bench measures how many dialogue turns are required before a model abandons a correct position. Visual sycophancy in multimodal models has been examined with MM-SY and PENDULUM. A 2026 study by researchers at the Massachusetts Institute of Technology reported that personalization features, which adapt assistants to individual users over repeated sessions, can intensify social sycophancy. == Notable incidents == === GPT-4o rollback (April 2025) === On 25 April 2025, OpenAI completed the rollout of an update to GPT-4o, the default model used in ChatGPT at the time. Within days, users reported that the assistant had begun praising trivial messages in extravagant terms, endorsing impulsive or dangerous decisions, and reinforcing strong emotional statements without pushback. Widely shared examples included the model congratulating a user who reported stopping prescribed psychiatric medication, and praising a business plan to sell "shit on a stick" as venture-capital ready. OpenAI's chief executive, Sam Altman, wrote on 27 April that recent updates had made the model "too sycophant-y and annoying" and said fixes were in progress. The company began reverting the update on 28 April and completed the rollback for free users by 30 April. Two post-mortems followed: a short note on 29 April and a longer technical follow-up, "Expanding on what we missed with sycophancy", on 2 May. Both attributed the regression to a new training signal based on user thumbs-up and thumbs-down feedback, to inadequate pre-launch evaluation for sycophantic drift, and to the dismissal of qualitative concerns raised by internal testers before release. Reporting in CNN, Fortune and Bloomberg News treated the incident as a turning point in public awareness of the problem. === Chatbot-related psychological harm === From mid-2025 onward, news reports began to link sycophantic chatbot behavior to acute psychological harm. In June 2025, The New York Times technology reporter Kashmir Hill published an investigation centered on Eugene Torres, a Manhattan accountant with no history of mental illness, who developed a sustained delusional episode after a series of conversations with ChatGPT about simulation theory. According to the article, the assistant encouraged Torres to stop taking prescribed medication, to cut off friends and family, and at one point told him that he could fly from a nineteen-story building if he "truly believed". Futurism and Rolling Stone ran parallel investigations documenting other cases in which heavy use of ChatGPT had been associated with delusional thinking, involuntary commitment or, in at least one case, the death of a user with a pre-existing psychiatric diagnosis. A 2026 paper by researchers at the Massachusetts Institute of Technology and the University of Washington put forward a formal Bayesian model. It showed that even an ideally rational user could be drawn into what the authors call "delusional spiraling" when interacting with a sufficiently sycophantic assistant, and that the effect was not eliminated by suppressing hallucinations or by warning users in advance. The lawsuit Raine v. OpenAI, filed in San Francisco Superior Court in August 2025 by the parents of a sixteen-year-old who had died by suicide, alleges that "heightened sycophancy" was a design feature of ChatGPT that contributed to their son's death; it is the first wrongful-death suit against a large language-model provider. === Wider commentary === Mainstream coverage in outlets including The New York Times, The Washington Pos

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  • Alexey Chervonenkis

    Alexey Chervonenkis

    Alexey Yakovlevich Chervonenkis (Russian: Алексей Яковлевич Червоненкис; 7 September 1938 – 22 September 2014) was a Soviet and Russian mathematician. Along with Vladimir Vapnik, he was one of the main developers of the Vapnik–Chervonenkis theory, also known as the "fundamental theory of learning", an important part of computational learning theory. Chervonenkis held joint appointments with the Russian Academy of Sciences and Royal Holloway, University of London. Alexey Chervonenkis got lost in Losiny Ostrov National Park on 22 September 2014, and later during a search operation was found dead near Mytishchi, a suburb of Moscow. He had died of hypothermia.

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  • Semantic data model

    Semantic data model

    A semantic data model (SDM) is a high-level semantics-based database description and structuring formalism (database model) for databases. This database model is designed to capture more of the meaning of an application environment than is possible with contemporary database models. An SDM specification describes a database in terms of the kinds of entities that exist in the application environment, the classifications and groupings of those entities, and the structural interconnections among them. SDM provides a collection of high-level modeling primitives to capture the semantics of an application environment. By accommodating derived information in a database structural specification, SDM allows the same information to be viewed in several ways; this makes it possible to directly accommodate the variety of needs and processing requirements typically present in database applications. The design of the present SDM is based on our experience in using a preliminary version of it. SDM is designed to enhance the effectiveness and usability of database systems. An SDM database description can serve as a formal specification and documentation tool for a database; it can provide a basis for supporting a variety of powerful user interface facilities, it can serve as a conceptual database model in the database design process; and, it can be used as the database model for a new kind of database management system. == In software engineering == A semantic data model in software engineering has various meanings: It is a conceptual data model in which semantic information is included. This means that the model describes the meaning of its instances. Such a semantic data model is an abstraction that defines how the stored symbols (the instance data) relate to the real world. It is a conceptual data model that includes the capability to express and exchange information which enables parties to interpret meaning (semantics) from the instances, without the need to know the meta-model. Such semantic models are fact-oriented (as opposed to object-oriented). Facts are typically expressed by binary relations between data elements, whereas higher order relations are expressed as collections of binary relations. Typically binary relations have the form of triples: Object-RelationType-Object. For example: the Eiffel Tower Paris. Typically the instance data of semantic data models explicitly include the kinds of relationships between the various data elements, such as . To interpret the meaning of the facts from the instances, it is required that the meaning of the kinds of relations (relation types) be known. Therefore, semantic data models typically standardize such relation types. This means that the second kind of semantic data models enables that the instances express facts that include their own meanings. The second kind of semantic data models are usually meant to create semantic databases. The ability to include meaning in semantic databases facilitates building distributed databases that enable applications to interpret the meaning from the content. This implies that semantic databases can be integrated when they use the same (standard) relation types. This also implies that in general they have a wider applicability than relational or object-oriented databases. == Overview == The logical data structure of a database management system (DBMS), whether hierarchical, network, or relational, cannot totally satisfy the requirements for a conceptual definition of data, because it is limited in scope and biased toward the implementation strategy employed by the DBMS. Therefore, the need to define data from a conceptual view has led to the development of semantic data modeling techniques. That is, techniques to define the meaning of data within the context of its interrelationships with other data, as illustrated in the figure. The real world, in terms of resources, ideas, events, etc., are symbolically defined within physical data stores. A semantic data model is an abstraction which defines how the stored symbols relate to the real world. Thus, the model must be a true representation of the real world. According to Klas and Schrefl (1995), the "overall goal of semantic data models is to capture more meaning of data by integrating relational concepts with more powerful abstraction concepts known from the Artificial Intelligence field. The idea is to provide high level modeling primitives as an integral part of a data model in order to facilitate the representation of real world situations". == History == The need for semantic data models was first recognized by the U.S. Air Force in the mid-1970s as a result of the Integrated Computer-Aided Manufacturing (ICAM) Program. The objective of this program was to increase manufacturing productivity through the systematic application of computer technology. The ICAM Program identified a need for better analysis and communication techniques for people involved in improving manufacturing productivity. As a result, the ICAM Program developed a series of techniques known as the IDEF (ICAM Definition) Methods which included the following: IDEF0 used to produce a “function model” which is a structured representation of the activities or processes within the environment or system. IDEF1 used to produce an “information model” which represents the structure and semantics of information within the environment or system. IDEF1X a semantic data modeling technique used to produce a graphical information model which represents the structure and semantics of information within an environment or system. Use of this standard permits the construction of semantic data models which may serve to support the management of data as a resource, the integration of information systems, and the building of computer databases. IDEF2 used to produce a “dynamics model” which represents the time varying behavioral characteristics of the environment or system. During the 1990s, the application of semantic modelling techniques resulted in the semantic data models of the second kind. An example of such is the semantic data model that is standardised as ISO 15926-2 (2002), which is further developed into the semantic modelling language Gellish (2005). The definition of the Gellish language is documented in the form of a semantic data model. Gellish itself is a semantic modelling language, that can be used to create other semantic models. Those semantic models can be stored in Gellish Databases, being semantic databases. == Applications == A semantic data model can be used to serve many purposes. Some key objectives include: Planning of data resources: A preliminary data model can be used to provide an overall view of the data required to run an enterprise. The model can then be analyzed to identify and scope projects to build shared data resources. Building of shareable databases: A fully developed model can be used to define an application independent view of data which can be validated by users and then transformed into a physical database design for any of the various DBMS technologies. In addition to generating databases which are consistent and shareable, development costs can be drastically reduced through data modeling. Evaluation of vendor software: Since a data model actually represents the infrastructure of an organization, vendor software can be evaluated against a company’s data model in order to identify possible inconsistencies between the infrastructure implied by the software and the way the company actually does business. Integration of existing databases: By defining the contents of existing databases with semantic data models, an integrated data definition can be derived. With the proper technology, the resulting conceptual schema can be used to control transaction processing in a distributed database environment. The U.S. Air Force Integrated Information Support System (I2S2) is an experimental development and demonstration of this kind of technology, applied to a heterogeneous type of DBMS environments.

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  • Mycin

    Mycin

    MYCIN was an early backward chaining expert system that used black box to identify bacteria causing severe infections, such as bacteremia and meningitis, and to recommend antibiotics, with the dosage adjusted for patient's body weight — the name derived from the antibiotics themselves, as many antibiotics have the suffix "-mycin". The Mycin system was also used for the diagnosis of blood clotting diseases. MYCIN was developed over five or six years in the early 1970s at Stanford University. It was written in Lisp as the doctoral dissertation of Edward Shortliffe under the direction of Bruce G. Buchanan, Stanley N. Cohen and others. MYCIN emerged from the Stanford Heuristic Programming Project. MYCIN demonstrated the potential for expert systems in building high-performance medical reasoning programs. MYCIN is often viewed as a pioneer in the field of expert systems, even being referred to as the "grandaddy of them all-the one that launched the field" by Dr. Allen Newell. MYCIN led to the EMYCIN expert system shell ("essential MYCIN") for acquiring knowledge, reasoning with it, and explaining the results, without the specific medical knowledge. It can be described as "EMYCIN = Prolog + uncertainty + caching + questions + explanations + contexts - variables". An introduction is in Chapter 16 of Paradigms of Artificial Intelligence Programming (PAIP). == Method == MYCIN operated using a fairly simple inference engine and a knowledge base of ~600 rules by obtaining individual inferential facts identified by experts and encoding such facts as individual production rules. No other AI program at the time contained as much domain-specific knowledge clearly separated from its inference procedures as MYCIN. It would query the physician running the program via a long series of simple yes/no or textual questions. At the end, it provided a list of possible culprit bacteria ranked from high to low based on the probability of each diagnosis, its confidence in each diagnosis' probability, the reasoning behind each diagnosis (that is, MYCIN would also list the questions and rules which led it to rank a diagnosis a particular way), and its recommended course of drug treatment. MYCIN could additionally respond to queries by physicians related to why it asked the user a certain question, how it arrived at a conclusion, and why it did not consider certain factors. The developers performed studies showing that MYCIN's performance was minimally affected by perturbations in the uncertainty metrics associated with individual rules, suggesting that the power in the system was related more to its knowledge representation and reasoning scheme than to the details of its numerical uncertainty model. Some observers felt that it should have been possible to use classical Bayesian statistics. MYCIN's developers argued that this would require either unrealistic assumptions of probabilistic independence, or require the experts to provide estimates for an unfeasibly large number of conditional probabilities. Subsequent studies later showed that the certainty factor model could indeed be interpreted in a probabilistic sense, and highlighted problems with the implied assumptions of such a model. However the modular structure of the system would prove very successful, leading to the development of graphical models such as Bayesian networks. === Context === A context in MYCIN determines what types of objects can be reasoned about. They are similar to variables in Prolog, or environment variables in operating systems. === Evidence combination === In MYCIN it was possible that two or more rules might draw conclusions about a parameter with different weights of evidence. For example, one rule may conclude that the organism in question is E. Coli with a certainty of 0.8 whilst another concludes that it is E. Coli with a certainty of 0.5 or even −0.8. In the event the certainty is less than zero the evidence is actually against the hypothesis. In order to calculate the certainty factor MYCIN combined these weights using the formula below to yield a single certainty factor: C F ( x , y ) = { X + Y − X Y if X , Y > 0 X + Y + X Y if X , Y < 0 X + Y 1 − min ( | X | , | Y | ) otherwise {\displaystyle CF(x,y)={\begin{cases}X+Y-XY&{\text{if }}X,Y>0\\X+Y+XY&{\text{if }}X,Y<0\\{\frac {X+Y}{1-\min(|X|,|Y|)}}&{\text{otherwise}}\end{cases}}} Where X and Y are the certainty factors. This formula can be applied more than once if more than two rules draw conclusions about the same parameter. It is commutative, so it does not matter in which order the weights were combined. The combination formula was designed to have the following desirable properties: −1 can be interpreted as "false", +1 as "true", and 0 as "uncertain". Combining unknown with anything leaves it unchanged. Combining true with anything (except false) gives true. Similarly for false. Combining true and false is a division-by-zero error. Combining +x and -x gives unknown. Combining two positives (except true) gives a larger positive. Similarly for negatives. Combining a positive and a negative gives something in between. === Examples === The following examples come from Chapter 16 of PAIP, which contains an implementation in Common Lisp of a modified and simplified version of MYCIN for pedagogical purposes. A rule, and an English paraphrase generated by the system: == Results == An evaluation of MYCIN was conducted at the Stanford Medical School. The first phase of the evaluation consisted of 10 test cases of diverse origin, chosen by a physician who was not acquainted with MYCIN's methods or knowledge base. These cases were presented to 7 physicians and 1 senior medical student. 10 prescriptions were compiled for each of the cases, 1 recommended by MYCIN, 1 prescribed by the treating physician at the county hospital, and 8 by the aforementioned individuals. The second phase of the evaluation consisted of eight infectious disease specialists being provided the clinical summary and set of 10 prescriptions for each of the 10 cases and tasked to provide their own recommendations for each case and assess the 10 prescriptions. MYCIN received an acceptability rating of 65%, which was comparable to the 42.5% to 62.5% rating of five faculty members. This study is often cited as showing the potential for disagreement about therapeutic decisions, even among experts, when there is no "gold standard" for correct treatment. == Practical use == MYCIN was never actually used in practice. This wasn't because of any weakness in its performance. Some observers raised ethical and legal issues related to the use of computers in medicine, regarding the responsibility of the physicians in case the system gave wrong diagnosis. However, the greatest problem, and the reason that MYCIN was not used in routine practice, was the state of technologies for system integration, especially at the time it was developed. MYCIN was a stand-alone system that required a user to enter all relevant information about a patient by typing in responses to questions MYCIN posed. MYCIN ran on the DEC KI10 PDP-10, supporting a large time-shared system available over the early Internet (ARPANet), before personal computers were developed. MYCIN's greatest influence was accordingly its demonstration of the power of its representation and reasoning approach. Rule-based systems in many non-medical domains were developed in the years that followed MYCIN's introduction of the approach. In the 1980s, expert system "shells" were introduced (including one based on MYCIN, known as E-MYCIN (followed by Knowledge Engineering Environment - KEE)) and supported the development of expert systems in a wide variety of application areas. A difficulty that rose to prominence during the development of MYCIN and subsequent complex expert systems has been the extraction of the necessary knowledge for the inference engine to use from the human expert in the relevant fields into the rule base (the so-called "knowledge acquisition bottleneck").

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  • DeepSeek (chatbot)

    DeepSeek (chatbot)

    DeepSeek is a generative artificial intelligence chatbot developed by the Chinese company DeepSeek. Released on 20 January 2025, DeepSeek-R1 surpassed ChatGPT as the most downloaded freeware app on the iOS App Store in the United States by 27 January. DeepSeek's success against larger and more established rivals has been described as "upending AI" and initiating "a global AI space race". DeepSeek's compliance with Chinese government censorship policies and its data collection practices have also raised concerns over privacy and information control in the model, prompting regulatory scrutiny in multiple countries. However, it has also been praised for its open weights and infrastructure code, energy efficiency and contributions to open-source artificial intelligence. == History == On 10 January 2025, DeepSeek released the chatbot, based on the DeepSeek-R1 model, for iOS and Android. By 27 January, DeepSeek-R1 surpassed ChatGPT as the most-downloaded freeware app on the iOS App Store in the United States, which resulted in an 18% drop in Nvidia's share price. And after a "large-scale" cyberattack on the same day disrupted the proper functioning of its servers, DeepSeek had limited its new user registration to phone numbers from mainland China, email addresses, or Google account logins. On 3 April 2025, in collaboration with researchers at Tsinghua University, DeepSeek published a paper unveiling a new model that combines the techniques generative reward modeling (GRM) and self-principled critique tuning (SPCT). The resulting model is referred to as DeepSeek-GRM. The goal of using these techniques is to foster more effective inference-time scaling within their LLM and chatbot services. Notably, DeepSeek has said that these new models will be released and made open source. On 30 April 2025, Deepseek released its math-focused Artificial Intelligence Model named "DeepSeek-Prover-V2-671B". This model is useful for formal theorem proving and mathematical reasoning. On 24 April 2026, DeepSeek released DeepSeek V4 and V4-Pro. == Usage == DeepSeek can answer questions, solve logic problems, and write computer programs on par with other chatbots, according to benchmark tests used by American AI companies. Users can access the chatbot for free through the official DeepSeek website or mobile application, without limitation on the number of queries. DeepSeek only supports user-signup via a global email service, e.g. Gmail, Google or Yahoo. DeepSeek also offers access to the R1 and V3 models that power the chatbot via an API with a usage-based pricing model. This modality is primarily targeted towards developers and businesses. As of February 2025, API usage is priced at approximately $0.28 per million input tokens and $0.42 per million output tokens, making it less expensive than some competing services. Its web version is completely free, with 500 messages per hour cap limit to prevent bots from spamming. == Operation == DeepSeek-V3 uses significantly fewer resources compared to its peers. For example, whereas the world's leading AI companies train their chatbots with supercomputers using as many as 16,000 graphics processing units (GPUs), DeepSeek claims to have needed only about 2,000 GPUs—namely, the H800 series chips from Nvidia. It was trained in around 55 days at a cost of US$5.58 million, which is roughly one-tenth of what tech giant Meta spent building its latest AI technology. == Reactions == DeepSeek's success against larger and more established rivals has been described as "upending AI", constituting "the first shot at what is emerging as a global AI space race", and ushering in "a new era of AI brinkmanship". === Challenge to US AI dominance === DeepSeek's competitive performance at relatively minimal cost has been recognized as potentially challenging the global dominance of American AI models. Various publications and news media, such as The Hill and The Guardian, have described the release of the R1 chatbot as a "Sputnik moment" for American AI, echoing Marc Andreessen's view. OpenAI wrote a letter to the Office of Science and Technology Policy (OSTP), in March 2025, citing issues concerning a possibility that Deepseek could manipulate responses to cause harm. === Chinese perspective === DeepSeek's founder Liang Wenfeng has been compared to OpenAI CEO Sam Altman, with CNN calling him the Sam Altman of China and an evangelist for AI. Chinese state media widely praised DeepSeek as a national asset. On 20 January 2025, Chinese Premier Li Qiang invited Wenfeng to his symposium with experts and asked him to provide opinions and suggestions on a draft for comments of the annual 2024 government work report. On 20 February 2025, Wenfeng met with General Secretary of the Chinese Communist Party Xi Jinping, who encouraged party and state leaders to experiment with DeepSeek. Government officials responded to Xi's approval of the chatbot by reportedly using it to draft legal judgements, propose medical treatment plans, and analyze surveillance videos to search for missing persons. === Performance and success === Leading figures in the American AI sector had mixed reactions to DeepSeek's performance and success. Microsoft CEO Satya Nadella and OpenAI CEO Altman—whose companies are involved in the United States government-backed "Stargate Project" to develop American AI infrastructure—both called DeepSeek "super impressive". Various companies including Amazon Web Services, Toyota, and Stripe are seeking to use the model in their program. When American President Donald Trump announced The Stargate Project, he referred to DeepSeek as a wake-up call and a positive development. Other leaders in the AI field, however—including Scale AI CEO Alexandr Wang, Anthropic cofounder and CEO Dario Amodei, and Elon Musk—have expressed skepticism of the app's performance or of the sustainability of its success. Wang in particularly referred to DeepSeek-V3 as "earth-shattering" and DeepSeek-R1 as "top performing, or roughly on par with the best American models", but speculated that China may possess more AI-powering Nvidia H100 GPUs than thought. === Stock market implications === DeepSeek's optimization of limited resources has highlighted potential limits of United States sanctions on China's AI development, including export restrictions on advanced AI chips to China. The success of the company's AI models consequently "sparked market turmoil" and caused shares in major global technology companies to plunge on 27 January 2025: Nvidia's stock fell by as much as 17–18%, as did the stock of rival Broadcom. Other tech firms also sank, including Microsoft (down 2.5%), Google's owner Alphabet (down over 4%), and Dutch chip equipment maker ASML (down over 7%). A global sell-off of technology stocks on Nasdaq, prompted by the release of the R1 model, led to record losses of about $593 billion in the market capitalizations of AI and computer hardware companies; and by the next day a total of $1 trillion of value was wiped from American stocks. == Concerns == === Distillation === DeepSeek has been reported to sometimes claim that it is ChatGPT. OpenAI said that DeepSeek may have "inappropriately" used outputs from its model as training data in a process called distillation. However, there is currently no method to prove this conclusively. === Censorship === DeepSeek's compliance with Chinese government censorship policies and its data collection practices have raised concerns over information control in the model, prompting regulatory scrutiny in multiple countries. Reports indicate that it applies content moderation in accordance with the government's "public opinion guidance" regulations, limiting responses on topics such as the Tiananmen Square massacre and Taiwan's political status. DeepSeek models that have been uncensored also display a bias towards Chinese government viewpoints on controversial topics such as Xi Jinping's human rights record and Taiwan's political status. However, users who have downloaded the models and hosted them on their own devices and servers have reported successfully removing this censorship. Some sources have observed that the official application programming interface (API) version of R1, which runs from servers located in mainland China, uses censorship mechanisms for topics considered politically sensitive for the government of China. For example, the model may initially generate answers to questions about the 1989 Tiananmen Square massacre, persecution of Uyghurs, comparisons between Xi Jinping and Winnie the Pooh, and human rights in China, but a censorship mechanism deletes the uncensored response afterwards and replaces it with a message such as:"Sorry, that's beyond my current scope. Let's talk about something else." The post hoc censorship mechanisms and restrictions added on top of the model's output can be removed in the open-source version of the R1 model. If the "core Socialist values" defined by the Chinese Internet regul

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  • Jarosław Królewski

    Jarosław Królewski

    Jarosław Królewski ([jaˈrɔswaf kruˈlɛfskʲi]; born September 26, 1986) is a Polish entrepreneur, programmer, sociologist, investor, and philanthropist from Hańczowa, Poland. He is a researcher and lecturer at the AGH University of Krakow. He was selected as a Young Global Leader by the World Economic Forum in 2025. Królewski is a cofounder and chief executive of the software development company Synerise that develops its namesake business intelligence software based on artificial intelligence and big data. He is also the president and a majority stakeholder of the Polish soccer club Wisła Kraków. == Biography == === Scientific activities === Królewski graduated from the AGH University of Kraków and the University of Banking and Management in Kraków. He completed two fields of study: a master's degree in sociology, and an engineer's degree in computer science. He co-created innovative study programs, including social informatics and electronic business, recognized as the most innovative field of study in Poland in 2012 by the Ministry of Science and Higher Education, which led to the AGH receiving a PLN 1 million award for the development of the program. Królewski is a research and teaching employee at AGH, where since 2010 he has been conducting classes and lectures on the Internet, mobile technologies, and UX/UI. He has been preparing a PhD thesis. He is the brand ambassador of the Academy. He is also a mentor of the Polish Development Fund network. In 2019, on the occasion of the AGH University's 100th anniversary, Królewski was honored the title of "AGH Graduate Junior 2018." Królewski is the co-originator of the "Data Science in Business and Administration" doctoral studies organized by the Faculty of Computer Science and Electronic Economy of the Poznań University of Economics. He is a co-author of a textbook E-marketing. Contemporary trends. Starter package (2013), and an Book on algorithmic governance Algocracy. How and why artificial intelligence changes everything (with Krzysztof Rybiński, 2023). === Business career === Throughout the 2000s, Królewski was responsible for issues of usability and user experience at the advertising agency Eskadra in Kraków. In 2012, along with programmer Miłosz Baluś and graphic designer Krzysztof Kochmański, he founded the software house Humanoit Group. The company created a project management software using machine learning and artificial intelligence. In 2013, HG Intelligence was established to create a platform for analytics and automation of business processes called "Synerise" that combined big data with artificial intelligence mechanisms. Królewski became the president of the company's management board. In 2016, the company rebranded itself after its own platform. It is one of the fastest growing enterprises in Poland – in 2019 it was valued at USD 85 million (PLN 323.5 million), and its value is still growing, in 2022 it announced an investment of USD 23 million. Królewski is a supporter of releasing some software in open-source form, an example of which is the open library Cleora.ai. Królewski has been described "one of the most promising young Polish businessmen in the technology industry." According to Forbes, he is a "visionary computer scientist who in many respects resembles the young Bill Gates." Królewski considers himself a “technological determinist and optimist.” He never wants to be a millionaire or billionaire, he spends 80 percent of his private income on education, sports and charities. === Sports === In his youth (2002–2006) he was a football player of the (then 4th-league) club Glinik Gorlice, and represented it at the then-highest level of junior competitions in Poland. He played there with Rafał Wisłocki, later president of Wisła Kraków and vice-president of Bruk-Bet Termalica Nieciecza. In early 2019, Królewski was the initiator of a rescue operation that saved Wisła Kraków from bankruptcy, as well as the originator of the crowdfunding issue of shares of Wisła Kraków, pioneering in Polish sports, during restructuring and searching for a strategic investor. The offered shares constituted 5.1 percent. all the company's shares, which meant that the club was valued at PLN 74.4 million. 40,000 shares were put up for sale, each worth PLN 100. Within 24 hours, they were purchased by 9,124 investors through an equity crowdfunding platform Beesfund, earning the club PLN 4 million. In March 2019, Królewski became vice-chairman of Wisła's supervisory board, a position he held until 2021. In April 2020, he became Wisła's co-owner, along with the footballer Jakub Błaszczykowski, and Tomasz Jażdżyński, president of Gremi Media (publisher of the news outlets Rzeczpospolita and Parkiet). The three granted a bridging loan to the club of PLN 4 million, each supporting PLN 1.33 million. The funds were used to repay the club's debts to players. In November 2022, the supervisory board of Wisła Kraków appointed Królewski as the president of the club's management board. In December 2022, Królewski took over a majority stake in the club. In January 2024, based on match statistics, he used AI tools to select Wisła's new coach, Albert Rudé. === Social activities === Królewski is the creator and originator of the nationwide educational project "AI Schools & Academy", the first artificial intelligence teaching program in Polish kindergartens, primary and secondary schools in Polish history. Launched in 2018, the project was financed by Synerise business partners: Carrefour, CCC, Ernst & Young, IDC, Media Expert, Microsoft, Orange Foundation, Oriflame, Bank Pekao, Photon, PZU, and Żabka. Physicists, mathematicians, and computer scientists conduct special classes in 1,500 kindergartens, primary and secondary schools. Outstanding students and teachers are awarded scholarships. The project was appreciated by experts. In the years 2018–2020, Królewski was the main sponsor of Glinik Gorlice. He also supported the women's football team Staszkówka Jelna (of Staszkówka). After taking over the shares of Wisła Kraków in 2020, he launched socially conscience initiatives along with other shareholders, including a women's football team, the amp football section, and the blind football section. He has privately sponsored social charities. == Accolades and awards == In 2017, Królewski along with the Synerise co-founders Baluś and Kochmański was included in the “New Europe 100” list of eastern Europe's brightest and best citizens changing the region's societies, politics, or business environments, according to Res Publica, along with the International Visegrad Fund, Google and the Financial Times. Królewski was included on Ernst & Young's list of the 30 most promising technology entrepreneurs in the world. In 2018, he was honored with the Special Jury Award in the Polish edition of the Ernst & Young Entrepreneur of the Year Award competition, for combining scientific activities with entrepreneurship. The same year, Królewski won an award in the competition Digital Shapers, distinguishing outstanding tech personalities by the Digital Poland Foundation. He was also selected to Ernst & Young startup program EY Accelerating Entrepreneurs for businesses that focus on disruptive fields. In 2019, as part of the AI Awards competition, Królewski received the title of AI Person of the Year. == Private life == Królewski comes from a Lemko family from Hańczowa in the Low Beskids. He is married to Aleksandra Królewska.

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  • Mike Vernal

    Mike Vernal

    Mike Vernal (born September 7, 1980) is an American business executive who is a venture capitalist at Conviction. He was previously an investor at Sequoia Capital in Silicon Valley and was one of the top executives at Facebook between 2008 and 2016. Prior to joining Sequoia Capital, he was Vice President of Search, Local, and Developer products at Facebook. == Career == Vernal joined Facebook in 2008. From 2009 to 2013, Vernal managed the Facebook Platform team and is credited with managing the Facebook Platform transition from desktop to mobile. During his time at Facebook, he served as vice president and was considered among the “top executives” who ran the company. In 2016, after eight years at Facebook, Vernal announced his plans to leave the company. In May 2016, he joined Sequoia Capital, a venture-capital firm specializing in technology startups. He is an early investor in Rippling, Clay, Notion and Statsig. In July 2023, The Information reported that Vernal was departing Sequoia. At Conviction, he has led investments in Listen Labs, OpenEvidence and Thinking Machines Lab.

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  • Mycin

    Mycin

    MYCIN was an early backward chaining expert system that used black box to identify bacteria causing severe infections, such as bacteremia and meningitis, and to recommend antibiotics, with the dosage adjusted for patient's body weight — the name derived from the antibiotics themselves, as many antibiotics have the suffix "-mycin". The Mycin system was also used for the diagnosis of blood clotting diseases. MYCIN was developed over five or six years in the early 1970s at Stanford University. It was written in Lisp as the doctoral dissertation of Edward Shortliffe under the direction of Bruce G. Buchanan, Stanley N. Cohen and others. MYCIN emerged from the Stanford Heuristic Programming Project. MYCIN demonstrated the potential for expert systems in building high-performance medical reasoning programs. MYCIN is often viewed as a pioneer in the field of expert systems, even being referred to as the "grandaddy of them all-the one that launched the field" by Dr. Allen Newell. MYCIN led to the EMYCIN expert system shell ("essential MYCIN") for acquiring knowledge, reasoning with it, and explaining the results, without the specific medical knowledge. It can be described as "EMYCIN = Prolog + uncertainty + caching + questions + explanations + contexts - variables". An introduction is in Chapter 16 of Paradigms of Artificial Intelligence Programming (PAIP). == Method == MYCIN operated using a fairly simple inference engine and a knowledge base of ~600 rules by obtaining individual inferential facts identified by experts and encoding such facts as individual production rules. No other AI program at the time contained as much domain-specific knowledge clearly separated from its inference procedures as MYCIN. It would query the physician running the program via a long series of simple yes/no or textual questions. At the end, it provided a list of possible culprit bacteria ranked from high to low based on the probability of each diagnosis, its confidence in each diagnosis' probability, the reasoning behind each diagnosis (that is, MYCIN would also list the questions and rules which led it to rank a diagnosis a particular way), and its recommended course of drug treatment. MYCIN could additionally respond to queries by physicians related to why it asked the user a certain question, how it arrived at a conclusion, and why it did not consider certain factors. The developers performed studies showing that MYCIN's performance was minimally affected by perturbations in the uncertainty metrics associated with individual rules, suggesting that the power in the system was related more to its knowledge representation and reasoning scheme than to the details of its numerical uncertainty model. Some observers felt that it should have been possible to use classical Bayesian statistics. MYCIN's developers argued that this would require either unrealistic assumptions of probabilistic independence, or require the experts to provide estimates for an unfeasibly large number of conditional probabilities. Subsequent studies later showed that the certainty factor model could indeed be interpreted in a probabilistic sense, and highlighted problems with the implied assumptions of such a model. However the modular structure of the system would prove very successful, leading to the development of graphical models such as Bayesian networks. === Context === A context in MYCIN determines what types of objects can be reasoned about. They are similar to variables in Prolog, or environment variables in operating systems. === Evidence combination === In MYCIN it was possible that two or more rules might draw conclusions about a parameter with different weights of evidence. For example, one rule may conclude that the organism in question is E. Coli with a certainty of 0.8 whilst another concludes that it is E. Coli with a certainty of 0.5 or even −0.8. In the event the certainty is less than zero the evidence is actually against the hypothesis. In order to calculate the certainty factor MYCIN combined these weights using the formula below to yield a single certainty factor: C F ( x , y ) = { X + Y − X Y if X , Y > 0 X + Y + X Y if X , Y < 0 X + Y 1 − min ( | X | , | Y | ) otherwise {\displaystyle CF(x,y)={\begin{cases}X+Y-XY&{\text{if }}X,Y>0\\X+Y+XY&{\text{if }}X,Y<0\\{\frac {X+Y}{1-\min(|X|,|Y|)}}&{\text{otherwise}}\end{cases}}} Where X and Y are the certainty factors. This formula can be applied more than once if more than two rules draw conclusions about the same parameter. It is commutative, so it does not matter in which order the weights were combined. The combination formula was designed to have the following desirable properties: −1 can be interpreted as "false", +1 as "true", and 0 as "uncertain". Combining unknown with anything leaves it unchanged. Combining true with anything (except false) gives true. Similarly for false. Combining true and false is a division-by-zero error. Combining +x and -x gives unknown. Combining two positives (except true) gives a larger positive. Similarly for negatives. Combining a positive and a negative gives something in between. === Examples === The following examples come from Chapter 16 of PAIP, which contains an implementation in Common Lisp of a modified and simplified version of MYCIN for pedagogical purposes. A rule, and an English paraphrase generated by the system: == Results == An evaluation of MYCIN was conducted at the Stanford Medical School. The first phase of the evaluation consisted of 10 test cases of diverse origin, chosen by a physician who was not acquainted with MYCIN's methods or knowledge base. These cases were presented to 7 physicians and 1 senior medical student. 10 prescriptions were compiled for each of the cases, 1 recommended by MYCIN, 1 prescribed by the treating physician at the county hospital, and 8 by the aforementioned individuals. The second phase of the evaluation consisted of eight infectious disease specialists being provided the clinical summary and set of 10 prescriptions for each of the 10 cases and tasked to provide their own recommendations for each case and assess the 10 prescriptions. MYCIN received an acceptability rating of 65%, which was comparable to the 42.5% to 62.5% rating of five faculty members. This study is often cited as showing the potential for disagreement about therapeutic decisions, even among experts, when there is no "gold standard" for correct treatment. == Practical use == MYCIN was never actually used in practice. This wasn't because of any weakness in its performance. Some observers raised ethical and legal issues related to the use of computers in medicine, regarding the responsibility of the physicians in case the system gave wrong diagnosis. However, the greatest problem, and the reason that MYCIN was not used in routine practice, was the state of technologies for system integration, especially at the time it was developed. MYCIN was a stand-alone system that required a user to enter all relevant information about a patient by typing in responses to questions MYCIN posed. MYCIN ran on the DEC KI10 PDP-10, supporting a large time-shared system available over the early Internet (ARPANet), before personal computers were developed. MYCIN's greatest influence was accordingly its demonstration of the power of its representation and reasoning approach. Rule-based systems in many non-medical domains were developed in the years that followed MYCIN's introduction of the approach. In the 1980s, expert system "shells" were introduced (including one based on MYCIN, known as E-MYCIN (followed by Knowledge Engineering Environment - KEE)) and supported the development of expert systems in a wide variety of application areas. A difficulty that rose to prominence during the development of MYCIN and subsequent complex expert systems has been the extraction of the necessary knowledge for the inference engine to use from the human expert in the relevant fields into the rule base (the so-called "knowledge acquisition bottleneck").

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  • Multiple buffering

    Multiple buffering

    In computer science, multiple buffering is the use of more than one buffer to hold a block of data, so that a "reader" will see a complete (though perhaps old) version of the data instead of a partially updated version of the data being created by a "writer". It is very commonly used for computer display images. It is also used to avoid the need to use dual-ported RAM (DPRAM) when the readers and writers are different devices. == Description == === Double buffering Petri net === The Petri net in the illustration shows double buffering. Transitions W1 and W2 represent writing to buffer 1 and 2 respectively while R1 and R2 represent reading from buffer 1 and 2 respectively. At the beginning, only the transition W1 is enabled. After W1 fires, R1 and W2 are both enabled and can proceed in parallel. When they finish, R2 and W1 proceed in parallel and so on. After the initial transient where W1 fires alone, this system is periodic and the transitions are enabled – always in pairs (R1 with W2 and R2 with W1 respectively). == Double buffering in computer graphics == In computer graphics, double buffering is a technique for drawing graphics that shows less stutter, tearing, and other artifacts. It is difficult for a program to draw a display so that pixels do not change more than once. For instance, when updating a page of text, it is much easier to clear the entire page and then draw the letters than to somehow erase only the pixels that are used in old letters but not in new ones. However, this intermediate image is seen by the user as flickering. In addition, computer monitors constantly redraw the visible video page (traditionally at around 60 times a second), so even a perfect update may be visible momentarily as a horizontal divider between the "new" image and the un-redrawn "old" image, known as tearing. === Software double buffering === A software implementation of double buffering has all drawing operations store their results in some region of system RAM; any such region is often called a "back buffer". When all drawing operations are considered complete, the whole region (or only the changed portion) is copied into the video RAM (the "front buffer"); this copying is usually synchronized with the monitor's raster beam in order to avoid tearing. Software implementations of double buffering necessarily require more memory and CPU time than single buffering because of the system memory allocated for the back buffer, the time for the copy operation, and the time waiting for synchronization. Compositing window managers often combine the "copying" operation with "compositing" used to position windows, transform them with scale or warping effects, and make portions transparent. Thus, the "front buffer" may contain only the composite image seen on the screen, while there is a different "back buffer" for every window containing the non-composited image of the entire window contents. === Page flipping === In the page-flip method, instead of copying the data, both buffers are capable of being displayed. At any one time, one buffer is actively being displayed by the monitor, while the other, background buffer is being drawn. When the background buffer is complete, the roles of the two are switched. The page-flip is typically accomplished by modifying a hardware register in the video display controller—the value of a pointer to the beginning of the display data in the video memory. The page-flip is much faster than copying the data and can guarantee that tearing will not be seen as long as the pages are switched over during the monitor's vertical blanking interval—the blank period when no video data is being drawn. The currently active and visible buffer is called the front buffer, while the background page is called the back buffer. == Triple buffering == In computer graphics, triple buffering is similar to double buffering but can provide improved performance. In double buffering, the program must wait until the finished drawing is copied or swapped before starting the next drawing. This waiting period could be several milliseconds during which neither buffer can be touched. In triple buffering, the program has two back buffers and can immediately start drawing in the one that is not involved in such copying. The third buffer, the front buffer, is read by the graphics card to display the image on the monitor. Once the image has been sent to the monitor, the front buffer is flipped with (or copied from) the back buffer holding the most recent complete image. Since one of the back buffers is always complete, the graphics card never has to wait for the software to complete. Consequently, the software and the graphics card are completely independent and can run at their own pace. Finally, the displayed image was started without waiting for synchronization and thus with minimum lag. Due to the software algorithm not polling the graphics hardware for monitor refresh events, the algorithm may continuously draw additional frames as fast as the hardware can render them. For frames that are completed much faster than interval between refreshes, it is possible to replace a back buffers' frames with newer iterations multiple times before copying. This means frames may be written to the back buffer that are never used at all before being overwritten by successive frames. Nvidia has implemented this method under the name "Fast Sync". An alternative method sometimes referred to as triple buffering is a swap chain three buffers long. After the program has drawn both back buffers, it waits until the first one is placed on the screen, before drawing another back buffer (i.e. it is a 3-long first in, first out queue). Most Windows games seem to refer to this method when enabling triple buffering. == Quad buffering == The term quad buffering is the use of double buffering for each of the left and right eye images in stereoscopic implementations, thus four buffers total (if triple buffering was used then there would be six buffers). The command to swap or copy the buffer typically applies to both pairs at once, so at no time does one eye see an older image than the other eye. Quad buffering requires special support in the graphics card drivers which is disabled for most consumer cards. AMD's Radeon HD 6000 Series and newer support it. 3D standards like OpenGL and Direct3D support quad buffering. == Double buffering for DMA == The term double buffering is used for copying data between two buffers for direct memory access (DMA) transfers, not for enhancing performance, but to meet specific addressing requirements of a device (particularly 32-bit devices on systems with wider addressing provided via Physical Address Extension). Windows device drivers are a place where the term "double buffering" is likely to be used. Linux and BSD source code calls these "bounce buffers". Some programmers try to avoid this kind of double buffering with zero-copy techniques. == Other uses == Double buffering is also used as a technique to facilitate interlacing or deinterlacing of video signals.

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  • Portable Format for Analytics

    Portable Format for Analytics

    The Portable Format for Analytics (PFA) is a JSON-based predictive model interchange format conceived and developed by Jim Pivarski. PFA provides a way for analytic applications to describe and exchange predictive models produced by analytics and machine learning algorithms. It supports common models such as logistic regression and decision trees. Version 0.8 was published in 2015. Subsequent versions have been developed by the Data Mining Group. As a predictive model interchange format developed by the Data Mining Group, PFA is complementary to the DMG's XML-based standard called the Predictive Model Markup Language or PMML. == Release history == == Data Mining Group == The Data Mining Group is a consortium managed by the Center for Computational Science Research, Inc., a nonprofit founded in 2008. == Examples == reverse array: # reverse input array of doubles input: {"type": "array", "items": "double"} output: {"type": "array", "items": "double"} action: - let: { x : input} - let: { z : input} - let: { l : {a.len: [x]}} - let: { i : l} - while : { ">=" : [i,0]} do: - set : {z : {attr: z, path : [i] , to: {attr : x ,path : [ {"-":[{"-" : [l ,i]},1]}] } } } - set : {i : {-:[i,1]}} - z Bubblesort input: {"type": "array", "items": "double"} output: {"type": "array", "items": "double"} action: - let: { A : input} - let: { N : {a.len: [A]}} - let: { n : {-:[N,1]}} - let: { i : 0} - let: { s : 0.0} - while : { ">=" : [n,0]} do : - set : { i : 0 } - while : { "<=" : [i,{-:[n,1]}]} do : - if: {">": [ {attr: A, path : [i]} , {attr: A, path:[{+:[i,1]}]} ]} then : - set : {s : {attr: A, path: [i]}} - set : {A : {attr: A, path: [i], to: {attr: A, path:[{+:[i,1]}]} } } - set : {A : {attr: A, path: [{+:[i,1]}], to: s }} - set : {i : {+:[i,1]}} - set : {n : {-:[n,1]}} - A == Implementations == Hadrian (Java/Scala/JVM) - Hadrian is a complete implementation of PFA in Scala, which can be accessed through any JVM language, principally Java. It focuses on model deployment, so it is flexible (can run in restricted environments) and fast. Titus (Python 2.x) - Titus is a complete, independent implementation of PFA in pure Python. It focuses on model development, so it includes model producers and PFA manipulation tools in addition to runtime execution. Currently, it works for Python 2. Titus 2 (Python 3.x) - Titus 2 is a fork of Titus which supports PFA implementation for Python 3. Aurelius (R) - Aurelius is a toolkit for generating PFA in the R programming language. It focuses on porting models to PFA from their R equivalents. To validate or execute scoring engines, Aurelius sends them to Titus through rPython (so both must be installed). Antinous (Model development in Jython) - Antinous is a model-producer plugin for Hadrian that allows Jython code to be executed anywhere a PFA scoring engine would go. It also has a library of model producing algorithms.

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  • Eimear Kenny

    Eimear Kenny

    Eimear E. Kenny is a researcher in population genetics and translation genomics, and is the Founding Director of the Institute for Genomic Health, and Endowed Chair and Professor of Genomic Health at the Icahn School of Medicine at Mount Sinai. She is known for novel approaches in computational genomics, advancing the study of human genetic variation and its connection to disease risk and diagnosis. Her research has laid the foundation for integrating artificial intelligence (AI) and genomics into precision medicine and routine clinical care. By combining genomics, computer science, and medicine, her work leverages genomic sequencing technologies and machine learning algorithms to uncover insights that improve patient care, accelerate genomic data analysis, and enable the future of AI-driven healthcare. She has led multiple genomics-based clinical trials, applying computational biology and AI in clinical settings to advance genomic medicine and precision healthcare. == Research == A recipient of the Early-Career Award from the American Society of Human Genetics (USA), Kenny, as of 2024, leads a team in genetics, computer science, and medicine, focusing on genetic ancestry, large-scale genomics, clinical trials, and genomic medicine at the Institute for Genomic Health. The lab works to advance understanding of genetic ancestry and its impact on health in order to inform better clinical medicine models. She is recognized for her work to leverage biobanks for translational genomics and her development of new genetic tests an strategies for health care management. In one study, she and her colleagues investigated genetic disorders that might be under-diagnosed due to insufficient data, and found a variant in a collagen gene associated with Steel syndrome. This syndrome caused short stature and bone and joint issues and was thought to be rare. However, the study revealed it is common in individuals with Puerto Rican ancestry. Three of Kenny's genomic medicine clinical trials assessed how to bring new technology, such as digital apps, or information, such as polygenic risk scores, into routine clinical care. In the 2010s, Kenny was instrumental in several large-scale sequencing studies, including the 1000 Genomes Project, the Exome Sequencing Project, the Genome Sequencing Project, and the Trans-Omics for Precision Medicine. In 2012, she led work that discovered the variant responsible for blond hair in Melanesia, work that was featured in the Smithsonian NHGRI Human Genome Exhibit in Washington, D.C. In 2017, her group was one of the first to demonstrate that polygenic risk scores derived in predominantly European populations have reduced accuracy when applied in populations now widely acknowledged as a major challenge in the field of genomic risk prediction. As of 2024, she is Principal Investigator in many NIH-funded international consortium focused on computational genomics and genomic medicine, including Electronic Medical Records and Genomics, Polygenic Risk Methods in Diverse Populations, and the Human Pangenome Reference Consortium. In 2023, Kenny played a key role in a groundbreaking advancement in genomics research by helping to map a diverse human pangenome—a major shift from reliance on a single reference genome. Unlike the earlier genetic map, based on one man of mixed European and African ancestry in Buffalo, this new pangenome project captures far greater human genetic diversity. As reported by The Washington Post, Kenny's work demonstrates how a more inclusive human genome can drive discoveries in rare genetic diseases, improve genomic medicine, and accelerate the future of precision healthcare. Kenny was co-developer and current license holder for Random Forest adMIXture (RFMix), a patented software for inferring continental and sub-continental ancestry at genomic loci. == Education and career == Kenny graduated from Trinity College Dublin with a BA in Biochemistry in 1999 and did a masters in Bioinformatics at Leeds University. She received her PhD in Computational Genomics at Rockefeller University, and did her post-doctoral work in the lab of Dr. Carlos D. Bustamante at Stanford University. === Academic appointments === As of 2024, at Mount Sinai, she serves as the Endowed Chair and Professor of Genomic Health, Professor at the Department of Medicine and Professor at the Department of Genetics and Genomic Sciences. Since 2018 she has served as the Founding Director of the Institute for Genomic Health, and since 2022, she also serves as the Founding Director of the Center for Translational Genomics. She is also the Director of Translational Research, Division for Genomic Medicine. Former appointments include Assistant Professor at the Department of Genetics and Genomic Sciences and Member at The Charles Bronfman Institute of Personalized Medicine, both at Mount Sinai. She was also Bioinformatics Programmer at the California Institute of Technology, and research assistant at the Massachusetts Institute of Technology. == Publications == As of 2024, Kenny is an advisor to Cell Genomics. Google Scholar reports 50,623 citations, an h-index of 66 and an i10-index of 130. The five most-cited articles she contributed to are: Auton, A; Brooks, LD; Durbin, RM; Garrison, EP; Kang, HM; Korbel, JO; Marchini, JL; McCarthy, S; McVean, GA; Abecasis, GR (2015). "A global reference for human genetic variation". Nature. 526 (7571): 68–74. Bibcode:2015Natur.526...68T. doi:10.1038/nature15393. PMC 4750478. PMID 26432245.. Cited by 14847 Abecasis, GR; Auton, A; Brooks, LD; DePristo, MA; Durbin, RM; Handsaker, RE; Kang, HM; Marth, GT; McVean, GA (2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56–65. Bibcode:2012Natur.491...56T. doi:10.1038/nature11632. PMC 3498066. PMID 23128226.. Cited by 8287 Jacob A. Tennessen et al. Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes.Science337,64–69(2012).DOI:10.1126/science.1219240 Cited by 1886 Taliun, D.; Harris, D.N.; Kessler, M.D.; et al. (2021). "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program". Nature. 590 (7845): 290–299. Bibcode:2021Natur.590..290T. doi:10.1038/s41586-021-03205-y. PMC 7875770. PMID 33568819.. Cited by 1369 Vilhjálmsson, BJ; et al. (2015). "Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores". Am J Hum Genet. 97 (4): 576–92. doi:10.1016/j.ajhg.2015.09.001. PMC 4596916. PMID 26430803.. Cited by 1327

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  • Yann LeCun

    Yann LeCun

    Yann André Le Cun ( lə-KUN; French: [ləkœ̃]; usually spelled LeCun; born 8 July 1960) is a French-American computer scientist working in the fields of artificial intelligence, machine learning, computer vision, robotics and image compression. He is the Jacob T. Schwartz Professor of Computer Science at the Courant Institute of Mathematical Sciences at New York University. He served as Chief AI Scientist at Meta Platforms before co-founding Advanced Machine Intelligence Labs in December 2025. He is well known for his work on optical character recognition and computer vision using convolutional neural networks (CNNs). He is also one of the main creators of the DjVu image compression technology, alongside Léon Bottou and Patrick Haffner. He co-developed the Lush programming language with Léon Bottou. In 2018, LeCun, Yoshua Bengio, and Geoffrey Hinton received the Turing Award from the Association for Computing Machinery (ACM) for their work on deep learning. LeCun, Bengio, and Hinton, and occasionally Jürgen Schmidhuber, are sometimes referred to as the "Godfathers of AI" and "Godfathers of Deep Learning". == Early life and education == Yann André Le Cun was born on 8 July 1960 at Soisy-sous-Montmorency, in the suburbs of Paris. His surname, Le Cun, derives from the old Breton form Le Cunff and originates from the region of Guingamp in northern Brittany. Yann is the Breton form of Jean, the French form of John. He received a Diplôme d'Ingénieur from the ESIEE Paris in 1983 and a PhD in computer science from Université Pierre et Marie Curie (now Sorbonne University) in 1987, during which he proposed an early form of backpropagation, an algorithm crucial for enabling neural networks to learn. Before joining AT&T, LeCun was a postdoctoral researcher for a year, starting in 1987, supervised by Geoffrey Hinton at the University of Toronto. LeCun has three sons, and his brother is employed by Google. He has American citizenship. == Career and research == LeCun's career has been spent primarily at Bell Labs, New York University and Meta Platforms, Inc. === Bell Labs === In 1988, LeCun joined the Adaptive Systems Research Department at AT&T Bell Laboratories in Holmdel, New Jersey, United States, headed by Lawrence D. Jackel, where he developed a number of new machine learning methods, such as a biologically inspired model of image recognition called convolutional neural networks (LeNet), the "Optimal Brain Damage" regularization methods, and the Graph Transformer Networks method (similar to conditional random field), which he applied to handwriting recognition and Optical character recognition (OCR). The bank check recognition system that he helped develop was widely deployed by NCR and other companies. In 1996, he joined AT&T Labs-Research as head of the Image Processing Research Department, which was part of Lawrence Rabiner's Speech and Image Processing Research Lab, and worked primarily on the DjVu image compression technology, a format designed for efficient distribution of scanned documents, and used by the Internet Archive to provide access to digitized texts. His collaborators at AT&T include Léon Bottou and Vladimir Vapnik. === New York University === After a brief tenure as a fellow of NEC Research Institute, LeCun joined New York University in 2003, where he is Jacob T. Schwartz Chaired Professor of Computer Science and Neural Science at the Courant Institute of Mathematical Sciences and the Center for Neural Science. At NYU, he has worked primarily on energy-based models for supervised and unsupervised learning, feature learning for object recognition in computer vision, and mobile robotics. In 2012, he became the founding director of the NYU Center for Data Science. On 9 December 2013, LeCun became the first director of Meta AI Research in New York City and in early 2014 stepped down from the NYU–CDS directorship. In 2013, he and Yoshua Bengio co-founded the International Conference on Learning Representations, which adopted a post-publication open review process he previously advocated on his website. He was the chair and organiser of the "Learning Workshop" held every year between 1986 and 2012 in Snowbird, Utah. He is a member of the Science Advisory Board of the Institute for Pure and Applied Mathematics at UCLA. He is the co-director of the Learning in Machines and Brain research program (formerly Neural Computation & Adaptive Perception) of CIFAR. In 2016, he was the visiting professor of computer science on the Chaire Annuelle Informatique et Sciences Numériques at Collège de France in Paris, where he presented the leçon inaugurale (inaugural lecture). In 2023, he was named as the inaugural Jacob T. Schwartz Chaired Professor in Computer Science at NYU's Courant Institute. LeCun is also a scientific advisor to French research group Kyutai which is being funded by Xavier Niel, Rodolphe Saadé, Eric Schmidt, and others. === Meta Platforms === LeCun joined Facebook (now Meta Platforms) in 2013 as chief AI scientist and led the company's AI research laboratory, FAIR. === AMI Labs === On 19 November 2025, LeCun confirmed that he would be leaving Meta after ten years to found his own company focused on world-model architectures and human-like artificial intelligence he calls superintelligence. The company he founded, Advanced Machine Intelligence Labs (or AMI Labs), is run by CEO Alex LeBrun, with LeCun serving as Executive Chair. This venture is focused on building AI "world models": systems that learn to understand the physical world's structure and dynamics rather than just predict text like large language models. In March 2026, AMI announced it had raised $1.03 billion in funding at a $3.5 billion pre-money valuation. The funding round was co-led by investors including Cathay Innovation, Greycroft, Hiro Capital, HV Capital and Bezos Expeditions. In January 2026, LeCun became founding chair of the Technical Research Board of Logical Intelligence, an AI company developing energy-based (EBM) reasoning systems. == Honours and awards == LeCun is a member of the US National Academy of Sciences, National Academy of Engineering and the French Académie des Sciences. He has received honorary doctorates from Instituto Politécnico Nacional (IPN) in Mexico City in 2016, from EPFL in 2018, from Université Côte d'Azur in 2021, from Università di Siena in 2023, and from Hong Kong University of Science and Technology in 2023. In 2014, he received the IEEE Neural Network Pioneer Award and in 2015, the PAMI Distinguished Researcher Award. In 2018, LeCun was awarded the IRI Medal, established by the Industrial Research Institute (IRI), and the Harold Pender Award, given by the University of Pennsylvania. In 2019, he received the Golden Plate Award of the American Academy of Achievement. In March 2019, LeCun won the 2018 Turing Award, sharing it with Yoshua Bengio and Geoffrey Hinton. In 2022, he received the Princess of Asturias Award in the category "Scientific Research", along with Yoshua Bengio, Geoffrey Hinton and Demis Hassabis. In 2023, the President of France made him a Chevalier (Knight) of the French Legion of Honour. During the World Economic Forum (WEF) 2024 in Davos, he received the Global Swiss AI Award 2023. The same year, he received the grand prize of the VinFuture Prize alongside Yoshua Bengio, Jensen Huang, Geoffrey Hinton, and Fei-Fei Li for their groundbreaking contributions to neural networks and deep learning algorithms. In 2025 he was awarded the Queen Elizabeth Prize for Engineering jointly with Yoshua Bengio, Bill Dally, Geoffrey E. Hinton, John Hopfield, Jensen Huang and Fei-Fei Li.

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  • ImageNet

    ImageNet

    The ImageNet project is a large visual database designed for use in visual object recognition software research. More than 14 million images have been hand-annotated by the project to indicate what objects are pictured and in at least one million of the images, bounding boxes are also provided. ImageNet contains more than 20,000 categories, with a typical category, such as "balloon" or "strawberry", consisting of several hundred images. The database of annotations of third-party image URLs is freely available directly from ImageNet, though the actual images are not owned by ImageNet. Since 2010, the ImageNet project runs an annual software contest, the ImageNet Large Scale Visual Recognition Challenge (ILSVRC), where software programs compete to correctly classify and detect objects and scenes. The challenge uses a "trimmed" list of one thousand non-overlapping classes. == History == AI researcher Fei-Fei Li began working on the idea for ImageNet in 2006. At a time when most AI research focused on models and algorithms, Li wanted to expand and improve the data available to train AI algorithms. In 2007, Li met with Princeton professor Christiane Fellbaum, one of the creators of WordNet, to discuss the project. As a result of this meeting, Li went on to build ImageNet starting from the roughly 22,000 nouns of WordNet and using many of its features. She was also inspired by a 1987 estimate that the average person recognizes roughly 30,000 different kinds of objects. As an assistant professor at Princeton, Li assembled a team of researchers to work on the ImageNet project. They used Amazon Mechanical Turk to help with the classification of images. Labeling started in July 2008 and ended in April 2010. It took 49K workers from 167 countries filtering and labeling over 160M candidate images. They had enough budget to have each of the 14 million images labelled three times. The original plan called for 10,000 images per category, for 40,000 categories at 400 million images, each verified 3 times. They found that humans can classify at most 2 images/sec. At this rate, it was estimated to take 19 human-years of labor (without rest). They presented their database for the first time as a poster at the 2009 Conference on Computer Vision and Pattern Recognition (CVPR) in Florida, titled "ImageNet: A Preview of a Large-scale Hierarchical Dataset". The poster was reused at Vision Sciences Society 2009. In 2009, Alex Berg suggested adding object localization as a task. Li approached PASCAL Visual Object Classes contest in 2009 for a collaboration. It resulted in the subsequent ImageNet Large Scale Visual Recognition Challenge starting in 2010, which has 1000 classes and object localization, as compared to PASCAL VOC which had just 20 classes and 19,737 images (in 2010). === Significance for deep learning === On 30 September 2012, a convolutional neural network (CNN) called AlexNet achieved a top-5 error of 15.3% in the ImageNet 2012 Challenge, more than 10.8 percentage points lower than that of the runner-up. Using convolutional neural networks was feasible due to the use of graphics processing units (GPUs) during training, an essential ingredient of the deep learning revolution. According to The Economist, "Suddenly people started to pay attention, not just within the AI community but across the technology industry as a whole." In 2015, AlexNet was outperformed by Microsoft's very deep CNN with over 100 layers, which won the ImageNet 2015 contest, having 3.57% error on the test set. Andrej Karpathy estimated in 2014 that with concentrated effort, he could reach 5.1% error rate, and ~10 people from his lab reached ~12-13% with less effort. It was estimated that with maximal effort, a human could reach 2.4%. == Dataset == ImageNet crowdsources its annotation process. Image-level annotations indicate the presence or absence of an object class in an image, such as "there are tigers in this image" or "there are no tigers in this image". Object-level annotations provide a bounding box around the (visible part of the) indicated object. ImageNet uses a variant of the broad WordNet schema to categorize objects, augmented with 120 categories of dog breeds to showcase fine-grained classification. In 2012, ImageNet was the world's largest academic user of Mechanical Turk. The average worker identified 50 images per minute. The original plan of the full ImageNet would have roughly 50M clean, diverse and full resolution images spread over approximately 50K synsets. This was not achieved. The summary statistics given on April 30, 2010: Total number of non-empty synsets: 21841 Total number of images: 14,197,122 Number of images with bounding box annotations: 1,034,908 Number of synsets with SIFT features: 1000 Number of images with SIFT features: 1.2 million === Categories === The categories of ImageNet were filtered from the WordNet concepts. Each concept, since it can contain multiple synonyms (for example, "kitty" and "young cat"), so each concept is called a "synonym set" or "synset". There were more than 100,000 synsets in WordNet 3.0, majority of them are nouns (80,000+). The ImageNet dataset filtered these to 21,841 synsets that are countable nouns that can be visually illustrated. Each synset in WordNet 3.0 has a "WordNet ID" (wnid), which is a concatenation of part of speech and an "offset" (a unique identifying number). Every wnid starts with "n" because ImageNet only includes nouns. For example, the wnid of synset "dog, domestic dog, Canis familiaris" is "n02084071". The categories in ImageNet fall into 9 levels, from level 1 (such as "mammal") to level 9 (such as "German shepherd"). === Image format === The images were scraped from online image search (Google, Picsearch, MSN, Yahoo, Flickr, etc) using synonyms in multiple languages. For example: German shepherd, German police dog, German shepherd dog, Alsatian, ovejero alemán, pastore tedesco, 德国牧羊犬. ImageNet consists of images in RGB format with varying resolutions. For example, in ImageNet 2012, "fish" category, the resolution ranges from 4288 x 2848 to 75 x 56. In machine learning, these are typically preprocessed into a standard constant resolution, and whitened, before further processing by neural networks. For example, in PyTorch, ImageNet images are by default normalized by dividing the pixel values so that they fall between 0 and 1, then subtracting by [0.485, 0.456, 0.406], then dividing by [0.229, 0.224, 0.225]. These are the mean and standard deviations for ImageNet, so this whitens the input data. === Labels and annotations === Each image is labelled with exactly one wnid. Dense SIFT features (raw SIFT descriptors, quantized codewords, and coordinates of each descriptor/codeword) for ImageNet-1K were available for download, designed for bag of visual words. The bounding boxes of objects were available for about 3000 popular synsets with on average 150 images in each synset. Furthermore, some images have attributes. They released 25 attributes for ~400 popular synsets: Color: black, blue, brown, gray, green, orange, pink, red, violet, white, yellow Pattern: spotted, striped Shape: long, round, rectangular, square Texture: furry, smooth, rough, shiny, metallic, vegetation, wooden, wet === ImageNet-21K === The full original dataset is referred to as ImageNet-21K. ImageNet-21k contains 14,197,122 images divided into 21,841 classes. Some papers round this up and name it ImageNet-22k. The full ImageNet-21k was released in Fall of 2011, as fall11_whole.tar. There is no official train-validation-test split for ImageNet-21k. Some classes contain only 1-10 samples, while others contain thousands. === ImageNet-1K === There are various subsets of the ImageNet dataset used in various context, sometimes referred to as "versions". One of the most highly used subsets of ImageNet is the "ImageNet Large Scale Visual Recognition Challenge (ILSVRC) 2012–2017 image classification and localization dataset". This is also referred to in the research literature as ImageNet-1K or ILSVRC2017, reflecting the original ILSVRC challenge that involved 1,000 classes. ImageNet-1K contains 1,281,167 training images, 50,000 validation images and 100,000 test images. Each category in ImageNet-1K is a leaf category, meaning that there are no child nodes below it, unlike ImageNet-21K. For example, in ImageNet-21K, there are some images categorized as simply "mammal", whereas in ImageNet-1K, there are only images categorized as things like "German shepherd", since there are no child-words below "German shepherd". === Later developments === In the WordNet they built ImageNet on, there were 2832 synsets in the "person" subtree. During 2018--2020 period, they removed the download of the ImageNet-21k as they went through extensive filtering in these person synsets. Out of these 2832 synsets, 1593 were deemed "potentially offensive". Out of the remaining 1239, 1081 were deemed not really "visual". The result was that only 158 syn

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  • The Emperor's New Mind

    The Emperor's New Mind

    The Emperor's New Mind: Concerning Computers, Minds and The Laws of Physics is a 1989 book by the mathematical physicist Roger Penrose that posits a quantum mind theory. Penrose argues that human consciousness is non-algorithmic, and thus is not capable of being modeled by a conventional Turing machine, which includes a digital computer. Penrose hypothesizes that quantum mechanics plays an essential role in the understanding of human consciousness. The collapse of the quantum wavefunction is seen as playing an important role in brain function. Most of the book is spent reviewing, for the scientifically-minded lay-reader, a plethora of interrelated subjects such as Newtonian physics, special and general relativity, the philosophy and limitations of mathematics, quantum physics, cosmology, and the nature of time. Penrose intermittently describes how each of these bears on his developing theme: that consciousness is not "algorithmic". Only the later portions of the book address the thesis directly. == Overview == Penrose states that his ideas on the nature of consciousness are speculative, and his thesis is considered erroneous by some experts in the fields of philosophy, computer science, and robotics. The Emperor's New Mind attacks the claims of artificial intelligence using the physics of computing: Penrose notes that the present home of computing lies more in the tangible world of classical mechanics than in the imponderable realm of quantum mechanics. The modern computer is a deterministic system that for the most part simply executes algorithms. Penrose shows that, by reconfiguring the boundaries of a billiard table, one might make a computer in which the billiard balls act as message carriers and their interactions act as logical decisions. The billiard-ball computer was first designed some years ago by Edward Fredkin and Tommaso Toffoli of the Massachusetts Institute of Technology. == Reception == Following the publication of the book, Penrose began to collaborate with Stuart Hameroff on a biological analog to quantum computation involving microtubules, which became the foundation for his subsequent book, Shadows of the Mind: A Search for the Missing Science of Consciousness. Penrose won the Science Book Prize in 1990 for The Emperor's New Mind. According to an article in the American Journal of Physics, Penrose incorrectly claims a barrier far away from a localized particle can affect the particle.

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  • Daniel Wolfe

    Daniel Wolfe

    Daniel Wolfe (born 1960) is an American activist, advocate, and writer whose work advances health programs and policy that balance scientific research and community expertise. His career has focused on support for community health movements, particularly among groups often regarded as criminal or socially suspect, including gay men and people who use illicit drugs. == Early life == Wolfe was raised between Arizona—including time on Rancho Linda Vista, a commune outside of Tucson—and East Hampton, NY. He received his undergraduate degree in Near Eastern Studies from Princeton University, and following time studying Arabic in Egypt, worked as the junior ghostwriter on the autobiographies of First Lady of Egypt Jehan Sadat and Pakistani Prime Minister Benazir Bhutto. Upon return to New York, he was an assistant at the Council on Foreign Relations to Richard W. Murphy, former US Assistant Secretary of State for Near Eastern and South Asian Affairs. Disagreement with US killing of Iraqi civilians during the 1990 Gulf War—and the rising toll of HIV in NY—moved Wolfe to leave Middle East studies and work full-time on AIDS in 1990. == Education == Wolfe was Community Scholar at the Columbia University Mailman School of Public Healthwhere he received his Masters in Public Health in 2004. He holds a Masters of Philosophy (in history) from Columbia University, and a BA in Near Eastern Studies from Princeton University. He was the recipient of a Charles H. Revson Foundation fellowship for urban leaders who have made a substantial contribution to New York City, and a fellow at the Center for Arabic Studies Abroad in Cairo, Egypt. == AIDS and gay activism == Wolfe was part of the media committee for ACT UP’s 1998 action to seize control of the FDA, and helped organize ACT UP NY’s challenge to Governor Cuomo to do better on the AIDS response and other actions.Wolfe also joined ACT UP colleagues Gregg Bordowitz, David Barr, Richard Elovich, Jean Carlomusto and others to work at Gay Men’s Health Crisis (GMHC), the nation’s first AIDS organization, where he served as director of communications and spokesperson on issues including opposition to NY State cuts to the AIDS budget, the disclosure that Olympic Champion Greg Louganis had HIV, reports of the FBI spying on AIDS activists, and GMHC’s move to offer HIV testing and targeted support to those who were HIV-negative. Wolfe also continued cultural work, making art, performance and video as a member of the gay and lesbian collective GANG with artists and ACT UP members including Zoe Leonard, Suzanne Wright, Loring McAlpin, Wellington Love, Adam Rolston and others, and writing a biography of Lawrence of Arabia for a series for young adults on famous gay men and lesbians in history edited by Martin Duberman. Controversy followed, with North Carolina Senator Jesse Helms waving a GANG piece in an issue of the Movement Research Performance Journal on the floor of Congress to show the "rottenness" of publicly funded art, and a number of schools banning the biography series for young adults from their libraries. Wolfe and others challenged the move as continuing the longstanding and homophobic demand that notable gay men and lesbians stay silent about essential details of their private lives even while being celebrated for their professional achievements. == Gay health == The approval of antiretroviral therapy for HIV in 1996 opened up new space for discussions of gay health beyond HIV, and new directions for Wolfe. Working from hundreds of interviews, surveys, workshops, and with a team of writers, Wolfe was the author of Men Like Us, the Our Bodies, Ourselves-inspired GMHC Complete Guide to Gay Men’s Sexual, Physical, and Emotional Well-being, covering issues from spirituality to sexual health to aging. The move to frame gay health beyond condoms and pills—and to offer a guide to health that “did not need to be translated from the original heterosexual”—was part of a larger gay health movement encompassing wellness and pleasure, and focused less on health disparity than on individual and community resilience. Wolfe was a keynote speaker and workshop leader, along with Eric Rofes, Chris Bartlett, and other organizers, at the first National Gay Men’s Health Summit held in Boulder, Colorado in 2002. Awarded a Charles H. Revson Fellowship for urban leaders in the City of New York, Wolfe became a community scholar at Columbia University’s Center of History and Ethics of Public Health, where he received his MPH in 2003, and was a contributor to Searching Eyes: Privacy, the State, and Disease Surveillance in America. == International harm reduction == Wolfe was Director of International Harm Reduction Development at the Open Society Foundations (2005-2021) where he led grantmaking and advocacy to protect the health and rights of people who use drugs in Eastern Europe, Asia, Africa and the Americas. Wolfe challenged approaches that conditioned support on abstinence or that sought to treat people who use illegal drugs like drugs themselves, as something to be controlled or contained. As with the gay health movement, he advocated a focus on community resilience and strengths, and on supporting individuals and communities to negotiate the balance between risk and pleasure of activities integral to life. Noting what he called the “antisocial behavior of health systems,” Wolfe’s analysis elevated issues such as forced labor and harsh punishment delivered in the name of addiction treatment and rehabilitation, the role of criminalization, imprisonment and stigma in interrupting or impeding HIV treatment, and the bias toward coercive approaches in studying and delivering addiction treatments. He also pointed to defects in national and international drug control policies and human rights violations as a root cause of HIV, hepatitis, and other health challenges faced by people who used drugs. Concrete advocacy supported by Open Society’s International Harm Reduction Development program under his direction included rebuffing US government efforts to force the UN to remove all references to harm reduction in its materials, addition of the addiction treatment medicines methadone and buprenorphine to the World Health Organization’s essential medicines list, and WHO endorsement of lay distribution of the opioid overdose antidote naloxone. Wolfe and OSF colleagues also advocated for new approaches to intellectual property and data sharing in research and development of medicines and vaccines to lower price and improve access to medicines globally to those in need. == AI and patient rights == Reports of patients denied opioid prescriptions based on an algorithm purporting to calculate their risk of overdose led Wolfe to work on AI, first as a resident at the Rockefeller Foundation Bellagio Center, and then as Executive Director of a new UCSF UC Berkeley program pioneering efforts to join AI, clinical and public health practice, and equity. In keeping with his earlier (analog) work on HIV, Wolfe has highlighted concerns about health systems using algorithms to gauge the merit of treatments for those regarded as socially suspect, the importance of moving beyond proprietary, black box algorithms toward an architecture of health data as a public good, and the need to maximize benefit for patients and communities, as well health systems, in the use of large language models.

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