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  Meta-learning (computer science)

  Meta-learning is a subfield of machine learning where automatic learning algorithms are applied to metadata about machine learning experiments. As of 2017, the term had not found a standard interpretation, however the main goal is to use such metadata to understand how automatic learning can become flexible in solving learning problems, hence to improve the performance of existing learning algorithms or to learn (induce) the learning algorithm itself, hence the alternative term learning to learn. Flexibility is important because each learning algorithm is based on a set of assumptions about the data, its inductive bias. This means that it will only learn well if the bias matches the learning problem. A learning algorithm may perform very well in one domain, but not on the next. This poses strong restrictions on the use of machine learning or data mining techniques, since the relationship between the learning problem (often some kind of database) and the effectiveness of different learning algorithms is not yet understood. By using different kinds of metadata, like properties of the learning problem, algorithm properties (like performance measures), or patterns previously derived from the data, it is possible to learn, select, alter or combine different learning algorithms to effectively solve a given learning problem. Critiques of meta-learning approaches bear a strong resemblance to the critique of metaheuristic, a possibly related problem. A good analogy to meta-learning, and the inspiration for Jürgen Schmidhuber's early work (1987) and Yoshua Bengio et al.'s work (1991), considers that genetic evolution learns the learning procedure encoded in genes and executed in each individual's brain. In an open-ended hierarchical meta-learning system using genetic programming, better evolutionary methods can be learned by meta evolution, which itself can be improved by meta meta evolution, etc. == Definition == A proposed definition for a meta-learning system combines three requirements: The system must include a learning subsystem. Experience is gained by exploiting meta knowledge extracted in a previous learning episode on a single dataset, or from different domains. Learning bias must be chosen dynamically. Bias refers to the assumptions that influence the choice of explanatory hypotheses and not the notion of bias represented in the bias-variance dilemma. Meta-learning is concerned with two aspects of learning bias. Declarative bias specifies the representation of the space of hypotheses, and affects the size of the search space (e.g., represent hypotheses using linear functions only). Procedural bias imposes constraints on the ordering of the inductive hypotheses (e.g., preferring smaller hypotheses). == Common approaches == There are three common approaches: using (cyclic) networks with external or internal memory (model-based) learning effective distance metrics (metrics-based) explicitly optimizing model parameters for fast learning (optimization-based). === Model-Based === Model-based meta-learning models updates its parameters rapidly with a few training steps, which can be achieved by its internal architecture or controlled by another meta-learner model. ==== Memory-Augmented Neural Networks ==== A Memory-Augmented Neural Network, or MANN for short, is claimed to be able to encode new information quickly and thus to adapt to new tasks after only a few examples. ==== Meta Networks ==== Meta Networks (MetaNet) learns a meta-level knowledge across tasks and shifts its inductive biases via fast parameterization for rapid generalization. === Metric-Based === The core idea in metric-based meta-learning is similar to nearest neighbors algorithms, which weight is generated by a kernel function. It aims to learn a metric or distance function over objects. The notion of a good metric is problem-dependent. It should represent the relationship between inputs in the task space and facilitate problem solving. ==== Convolutional Siamese Neural Network ==== Siamese neural network is composed of two twin networks whose output is jointly trained. There is a function above to learn the relationship between input data sample pairs. The two networks are the same, sharing the same weight and network parameters. ==== Matching Networks ==== Matching Networks learn a network that maps a small labelled support set and an unlabelled example to its label, obviating the need for fine-tuning to adapt to new class types. ==== Relation Network ==== The Relation Network (RN), is trained end-to-end from scratch. During meta-learning, it learns to learn a deep distance metric to compare a small number of images within episodes, each of which is designed to simulate the few-shot setting. ==== Prototypical Networks ==== Prototypical Networks learn a metric space in which classification can be performed by computing distances to prototype representations of each class. Compared to recent approaches for few-shot learning, they reflect a simpler inductive bias that is beneficial in this limited-data regime, and achieve satisfied results. === Optimization-Based === What optimization-based meta-learning algorithms intend for is to adjust the optimization algorithm so that the model can be good at learning with a few examples. ==== LSTM Meta-Learner ==== LSTM-based meta-learner is to learn the exact optimization algorithm used to train another learner neural network classifier in the few-shot regime. The parametrization allows it to learn appropriate parameter updates specifically for the scenario where a set amount of updates will be made, while also learning a general initialization of the learner (classifier) network that allows for quick convergence of training. ==== Temporal Discreteness ==== Model-Agnostic Meta-Learning (MAML) is a fairly general optimization algorithm, compatible with any model that learns through gradient descent. ==== Reptile ==== Reptile is a remarkably simple meta-learning optimization algorithm, given that both of its components rely on meta-optimization through gradient descent and both are model-agnostic. == Examples == Some approaches which have been viewed as instances of meta-learning: Recurrent neural networks (RNNs) are universal computers. In 1993, Jürgen Schmidhuber showed how "self-referential" RNNs can in principle learn by backpropagation to run their own weight change algorithm, which may be quite different from backpropagation. In 2001, Sepp Hochreiter & A.S. Younger & P.R. Conwell built a successful supervised meta-learner based on Long short-term memory RNNs. It learned through backpropagation a learning algorithm for quadratic functions that is much faster than backpropagation. Researchers at Deepmind (Marcin Andrychowicz et al.) extended this approach to optimization in 2017. In the 1990s, Meta Reinforcement Learning or Meta RL was achieved in Schmidhuber's research group through self-modifying policies written in a universal programming language that contains special instructions for changing the policy itself. There is a single lifelong trial. The goal of the RL agent is to maximize reward. It learns to accelerate reward intake by continually improving its own learning algorithm which is part of the "self-referential" policy. An extreme type of Meta Reinforcement Learning is embodied by the Gödel machine, a theoretical construct which can inspect and modify any part of its own software which also contains a general theorem prover. It can achieve recursive self-improvement in a provably optimal way. Model-Agnostic Meta-Learning (MAML) was introduced in 2017 by Chelsea Finn et al. Given a sequence of tasks, the parameters of a given model are trained such that few iterations of gradient descent with few training data from a new task will lead to good generalization performance on that task. MAML "trains the model to be easy to fine-tune." MAML was successfully applied to few-shot image classification benchmarks and to policy-gradient-based reinforcement learning. Variational Bayes-Adaptive Deep RL (VariBAD) was introduced in 2019. While MAML is optimization-based, VariBAD is a model-based method for meta reinforcement learning, and leverages a variational autoencoder to capture the task information in an internal memory, thus conditioning its decision making on the task. When addressing a set of tasks, most meta learning approaches optimize the average score across all tasks. Hence, certain tasks may be sacrificed in favor of the average score, which is often unacceptable in real-world applications. By contrast, Robust Meta Reinforcement Learning (RoML) focuses on improving low-score tasks, increasing robustness to the selection of task. RoML works as a meta-algorithm, as it can be applied on top of other meta learning algorithms (such as MAML and VariBAD) to increase their robustness. It is applicable to both supervised meta learning and meta reinforcement learning. Discovering meta-knowledge works by inducing knowledge

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  Pommerman Challenge

  The Pommerman Challenge is a multi-agent game to test autonomous artificial intelligence systems. == Game structure == Two-agent team compete against each other on an 11 x 11 board. Each agent can observe only part of the board, and the agents cannot communicate. The goal is to knock down the opponents. Agents place explosives to destroy walls and collect power-ups that appear from those walls, while avoiding death. Game objects can move unpredictably or be moved by an agent. == Play == The game involves real-time decision making. Agents must choose moves in about .1 seconds. == Algorithms == The real-time requirement limits the use of compute-heavy techniques such as Monte Carlo tree search. The branching factor at each move can be as large as 1,296, because all four agents act in each step, choosing among six possibilities. The agents choose by accounting for explosions, which have lifetimes of 10 steps. Explosions derail tree search techniques, as searches with less than 10 levels ignore explosions while deeper searches consider too many choices (given the branching factor). A hybrid approach uses a limited-depth tree search followed by exploring a deterministic/pessimistic scenario. Limiting the depth keeps the search tree small. The deterministic approach can predict far in the future, by omitting branching. "Good" actions are often those that perform well under pessimistic scenarios, particularly if safety is important. Identifying the worst sequence of positions for an object can suggest where to move it. After generating pessimistic scenarios, the agent quantifies the survivability of each move, notionally the number of positions in which the agent can then remain safely (without encountering other agents). == Competitions == 3 competitions were organized with slightly changing rules during 2018–2019. === Online - FFA === This round was a warm-up online event, where each competitor controlled only one agent. Results: 1st: Agent47Agent by Yichen Gong 2nd: aiKiller by Márton Görög === NeurIPS 2018 - Team === The first Pommerman competition with in-person finals. Results: 1st: hakozakijunctions by Toshihiro Takahashi 2nd: eisenach by Márton Görög 3rd: dypm by Takayuki Osogami The 3 best performing solutions used online tree search. === NeurIPS 2019 - Team Radio === The second competition with in-person finals improved communication between teammate agents. Results: 1st: Márton Görög 2nd: Paul Jasek 3rd: Yifan Zhang

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  Dominic Harris

  Dominic Harris (born 16 November 1976) is a British artist known for integrating modern technology and classical design in his interactive artworks. == Background == Dominic Harris was born in London on 16 November 1976, and grew up in London, Brussels, and Michigan before returning to London in 1995. Harris attended the Cranbrook Kingswood Upper School, and then trained as an architect at the Bartlett School of Architecture, and has been ARB registered since 2011. Harris designs and fabricates his artworks at Dominic Harris Studio, a multi-disciplinary practice he founded in 2007. This studio consists of 25 people with diverse backgrounds including architecture, product design, electronics, programming, graphic design, and workshop skills. Harris uses the resources of his studio for the ongoing development, prototyping and production of his artworks. Harris also oversees the studio's international projects where his fascinations are translated into larger scale projects that span residential, retail, and public art projects. In 2015, Harris was granted permission by the Walt Disney Company to use their Intellectual Property for the purpose of making new interactive artworks. Harris is the only artist to gain permission to use Disney's back catalogue of characters, and led him to creating his interactive versions of "Snow White and the Seven Dwarfs" and "Mickey and Minnie: An Interactive Diptych". Harris is fascinated by the idea of using data streams, algorithms, and computer code to generate dynamic and ever-changing artworks. He sees data as a raw material that can be transformed into visual poetry. Many of his installations and sculptures are interactive, responding to the presence and movement of viewers/participants. This creates an immersive experience where the observer becomes part of the artwork itself. Harris is also the founding partner of a sister studio in London called Cinimod Studio that creates large commissioned installations, interactive events and lighting designs for large brands. == Works == == Exhibitions == The works of Dominic Harris have been exhibited internationally, both through direct and gallery representation. Solo shows: "Feeding Consciousness" at Halcyon Gallery, Mayfair, London, UK – 2023 "US: NOW" at Halcyon Gallery, Mayfair, London, UK – 2020 "Imagine" at Halcyon Gallery, Mayfair, London, UK – 2019 "5 Year Celebration", Priveekollektie Contemporary Art | Design, London, UK – 2016. "Moments of Reflection" at PHOS ART + DESIGN, Mayfair, London, UK – 2015 Recent exhibitions include: In Plain Sight, 2024 Halcyon Gallery Victoria & Albert Museum Dublin Science Museum Design Miami / Basel Design Miami Art Miami Art 14, London PAD Paris PAD London Art Geneva == Gallery Representation == 2010 to 2019: Dominic Harris was represented by Priveekollektie Contemporary Art | Design, a Dutch gallery based in Heusden, the Netherlands, and with a regular presence on the international art and design circuits. 2015: Dominic Harris was shown with PHOS ART + DESIGN Gallery, in Mayfair, London, UK. 2019 – ongoing: Dominic Harris is exclusively represented by the Halcyon Gallery, an established international gallery based in Mayfair, London. == Collections == The majority of Harris's work has been bought by private collectors. Since 2012 Harris's work is also being acquired by several large institutional collections, including the Borusan Contemporary Art Collection in Istanbul. Harris's artworks include some of the biggest and most respected international art collectors and are also displayed in public spaces. == Books == Dominic Harris: Feeding Consciousness. Halcyon Gallery, 2023. Imagine: Dominic Harris (exhibition catalogue). Halcyon Gallery, 2019. A Touch Of Code: Documents the "Beacon" art installation and "Flutter" artwork (ISBN 978-3899553314) Dominic Harris, Artworks, Edition Eight. (ISBN 978-0957306325) Digital Real: Kunst & Nachhaltigkeit Vol 8.

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  With Folded Hands ...

  "With Folded Hands ..." is a 1947 science fiction novelette by American writer Jack Williamson (1908–2006). In writing it, Williamson was influenced by the aftermath of World War II, the atomic bombings of Hiroshima and Nagasaki, and his concern that "some of the technological creations we had developed with the best intentions might have disastrous consequences in the long run." The novelette first appeared in the July 1947 issue of Astounding Science Fiction and was later included in The Science Fiction Hall of Fame, Volume Two (1973) after being voted one of the best novellas up to 1965. In 1950, it was the first of several Astounding stories adapted for NBC's radio series Dimension X. == Rewrite and sequel == The 1947 publication was followed by a novel-length rewrite, with a different setting and inventor. At the behest of Astounding editor-in-chief John W. Campbell, a new ending had the robots defeated by means of what Williamson and Campbell would later christen "psionics". This novel was serialized, also in Astounding (March, April, May 1948), as ... And Searching Mind, and finally published in hardback book form as The Humanoids (1949). Much later, in 1980, Williamson followed with another sequel, The Humanoid Touch. == Plot summary == Underhill, a seller of "Mechanicals" (unthinking robots that perform menial tasks) in the small town of Two Rivers, is startled to find a competitor's store on his way home. The competitors are not humans but are small black robots who appear more advanced than anything Underhill has encountered before. They describe themselves as "humanoids". Disturbed at his encounter, Underhill rushes home to discover that his wife has taken in a new lodger, a mysterious old man named Sledge. In the course of the next day, the new Mechanicals have appeared everywhere in town. They state that they only follow the Prime Directive: "to serve and obey and guard men from harm". Offering their services free of charge, they replace humans as police officers, bank tellers, and more, and eventually drive Underhill out of business. Despite the humanoids' benign appearance and mission, Underhill soon realizes that, in the name of their Prime Directive, the mechanicals have essentially taken over every aspect of human life. No humans may engage in any behavior that might endanger them, and every human action is carefully scrutinized. Suicide is prohibited. Humans who resist the Prime Directive are taken away and lobotomized, so that they may live happily under the direction of the humanoids. Underhill learns that his lodger Sledge is the creator of the humanoids and is on the run from them. Sledge explains that 60 years earlier he had discovered the force of "rhodomagnetics" on the planet Wing IV and that his discovery resulted in a war that destroyed his planet. In his grief, Sledge designed the humanoids to help humanity and be invulnerable to human exploitation. However, he eventually realized that they had instead taken control of humanity, in the name of their Prime Directive, to make humans happy. The humanoids are spreading out from Wing IV to every human-occupied planet to implement their Prime Directive. Sledge and Underhill attempt to stop the humanoids by aiming a rhodomagnetic beam at Wing IV, but fail. The humanoids take Sledge away for surgery. He returns with no memory of his prior life, stating that he is now happy under the humanoids' care. Underhill is driven home by the humanoids, sitting "with folded hands," as there is nothing left to do. == Origins == In a 1991 interview, Williamson revealed how the story construction reflected events of his childhood in addition to technological extrapolations: I wrote "With Folded Hands" immediately after World War II, when the shadow of the atomic bomb had just fallen over SF and was just beginning to haunt the imaginations of people in the US. The story grows out of that general feeling that some of the technological creations we had developed with the best intentions might have disastrous consequences in the long run (that idea, of course, still seems relevant today). The notion I was consciously working on specifically came out of a fragment of a story I had worked on for a while about an astronaut in space who is accompanied by a robot obviously superior to him physically—i.e., the robot wasn't hurt by gravity, extremes of temperature, radiation, or whatever. Just looking at the fragment gave me the sense of how inferior humanity is in many ways to mechanical creations. That basic recognition was the essence of the story, and as I wrote it up in my notes the theme was that the perfect machine would prove to be perfectly destructive... It was only when I looked back at the story much later on that I was able to realize that the emotional reach of the story undoubtedly derived from my own early childhood, when people were attempting to protect me from all those hazardous things a kid is going to encounter in the isolated frontier setting I grew up in. As a result, I felt frustrated and over protected by people whom I couldn't hate because I loved them. A sort of psychological trap. Specifically, the first three years of my life were spent on a ranch at the top of the Sierra Madre Mountains on the headwaters of the Yaqui River in Sonora, Mexico. ... [My mother] was terrified by this environment. My father built a crib that became a psychological prison for me, particularly because my mother apparently kept me in it too long, when I needed to get out and crawl on the floor. ... In retrospect, I'm certain I projected my fears and suspicions of this kind of conditioning, and these projections became the governing emotional principle of "With Folded Hands" and The Humanoids. == Reception == In 2024, Robert Silverberg wrote an essay in which he asserted that "With Folded Hands..." is "probably the best story ever written about robots" and suggested that Elon Musk's Optimus Generation 2 is the realization of the "humanoids" along with their worst drawbacks.

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  Latent semantic analysis

  Latent semantic analysis (LSA) is a technique in natural language processing, in particular distributional semantics, of analyzing relationships between a set of documents and the terms they contain by producing a set of concepts related to the documents and terms. LSA assumes that words that are close in meaning will occur in similar pieces of text (the distributional hypothesis). A matrix containing word counts per document (rows represent unique words and columns represent each document) is constructed from a large piece of text and a mathematical technique called singular value decomposition (SVD) is used to reduce the number of rows while preserving the similarity structure among columns. Documents are then compared by cosine similarity between any two columns. Values close to 1 represent very similar documents while values close to 0 represent very dissimilar documents. An information retrieval technique using latent semantic structure was patented in 1988 by Scott Deerwester, Susan Dumais, George Furnas, Richard Harshman, Thomas Landauer, Karen Lochbaum and Lynn Streeter. In the context of its application to information retrieval, it is sometimes called latent semantic indexing (LSI). == Overview == === Occurrence matrix === LSA can use a document-term matrix which describes the occurrences of terms in documents; it is a sparse matrix whose rows correspond to terms and whose columns correspond to documents. A typical example of the weighting of the elements of the matrix is tf-idf (term frequency–inverse document frequency): the weight of an element of the matrix is proportional to the number of times the terms appear in each document, where rare terms are upweighted to reflect their relative importance. This matrix is also common to standard semantic models, though it is not necessarily explicitly expressed as a matrix, since the mathematical properties of matrices are not always used. === Rank lowering === After the construction of the occurrence matrix, LSA finds a low-rank approximation to the term-document matrix. There could be various reasons for these approximations: The original term-document matrix is presumed too large for the computing resources; in this case, the approximated low rank matrix is interpreted as an approximation (a "least and necessary evil"). The original term-document matrix is presumed noisy: for example, anecdotal instances of terms are to be eliminated. From this point of view, the approximated matrix is interpreted as a de-noisified matrix (a better matrix than the original). The original term-document matrix is presumed overly sparse relative to the "true" term-document matrix. That is, the original matrix lists only the words actually in each document, whereas we might be interested in all words related to each document—generally a much larger set due to synonymy. The consequence of the rank lowering is that some dimensions are combined and depend on more than one term: {(car), (truck), (flower)} → {(1.3452 car + 0.2828 truck), (flower)} This mitigates the problem of identifying synonymy, as the rank lowering is expected to merge the dimensions associated with terms that have similar meanings. It also partially mitigates the problem with polysemy, since components of polysemous words that point in the "right" direction are added to the components of words that share a similar meaning. Conversely, components that point in other directions tend to either simply cancel out, or, at worst, to be smaller than components in the directions corresponding to the intended sense. === Derivation === Let X {\displaystyle X} be a matrix where element ( i , j ) {\displaystyle (i,j)} describes the occurrence of term i {\displaystyle i} in document j {\displaystyle j} (this can be, for example, the frequency). X {\displaystyle X} will look like this: d j ↓ t i T → [ x 1 , 1 … x 1 , j … x 1 , n ⋮ ⋱ ⋮ ⋱ ⋮ x i , 1 … x i , j … x i , n ⋮ ⋱ ⋮ ⋱ ⋮ x m , 1 … x m , j … x m , n ] {\displaystyle {\begin{matrix}&{\textbf {d}}_{j}\\&\downarrow \\{\textbf {t}}_{i}^{T}\rightarrow &{\begin{bmatrix}x_{1,1}&\dots &x_{1,j}&\dots &x_{1,n}\\\vdots &\ddots &\vdots &\ddots &\vdots \\x_{i,1}&\dots &x_{i,j}&\dots &x_{i,n}\\\vdots &\ddots &\vdots &\ddots &\vdots \\x_{m,1}&\dots &x_{m,j}&\dots &x_{m,n}\\\end{bmatrix}}\end{matrix}}} Now a row in this matrix will be a vector corresponding to a term, giving its relation to each document: t i T = [ x i , 1 … x i , j … x i , n ] {\displaystyle {\textbf {t}}_{i}^{T}={\begin{bmatrix}x_{i,1}&\dots &x_{i,j}&\dots &x_{i,n}\end{bmatrix}}} Likewise, a column in this matrix will be a vector corresponding to a document, giving its relation to each term: d j = [ x 1 , j ⋮ x i , j ⋮ x m , j ] {\displaystyle {\textbf {d}}_{j}={\begin{bmatrix}x_{1,j}\\\vdots \\x_{i,j}\\\vdots \\x_{m,j}\\\end{bmatrix}}} Now the dot product t i T t p {\displaystyle {\textbf {t}}_{i}^{T}{\textbf {t}}_{p}} between two term vectors gives the correlation between the terms over the set of documents. The matrix product X X T {\displaystyle XX^{T}} contains all these dot products. Element ( i , p ) {\displaystyle (i,p)} (which is equal to element ( p , i ) {\displaystyle (p,i)} ) contains the dot product t i T t p {\displaystyle {\textbf {t}}_{i}^{T}{\textbf {t}}_{p}} ( = t p T t i {\displaystyle ={\textbf {t}}_{p}^{T}{\textbf {t}}_{i}} ). Likewise, the matrix X T X {\displaystyle X^{T}X} contains the dot products between all the document vectors, giving their correlation over the terms: d j T d q = d q T d j {\displaystyle {\textbf {d}}_{j}^{T}{\textbf {d}}_{q}={\textbf {d}}_{q}^{T}{\textbf {d}}_{j}} . Now, from the theory of linear algebra, there exists a decomposition of X {\displaystyle X} such that U {\displaystyle U} and V {\displaystyle V} are orthogonal matrices and Σ {\displaystyle \Sigma } is a diagonal matrix. This is called a singular value decomposition (SVD): X = U Σ V T {\displaystyle {\begin{matrix}X=U\Sigma V^{T}\end{matrix}}} The matrix products giving us the term and document correlations then become X X T = ( U Σ V T ) ( U Σ V T ) T = ( U Σ V T ) ( V T T Σ T U T ) = U Σ V T V Σ T U T = U Σ Σ T U T X T X = ( U Σ V T ) T ( U Σ V T ) = ( V T T Σ T U T ) ( U Σ V T ) = V Σ T U T U Σ V T = V Σ T Σ V T {\displaystyle {\begin{matrix}XX^{T}&=&(U\Sigma V^{T})(U\Sigma V^{T})^{T}=(U\Sigma V^{T})(V^{T^{T}}\Sigma ^{T}U^{T})=U\Sigma V^{T}V\Sigma ^{T}U^{T}=U\Sigma \Sigma ^{T}U^{T}\\X^{T}X&=&(U\Sigma V^{T})^{T}(U\Sigma V^{T})=(V^{T^{T}}\Sigma ^{T}U^{T})(U\Sigma V^{T})=V\Sigma ^{T}U^{T}U\Sigma V^{T}=V\Sigma ^{T}\Sigma V^{T}\end{matrix}}} Since Σ Σ T {\displaystyle \Sigma \Sigma ^{T}} and Σ T Σ {\displaystyle \Sigma ^{T}\Sigma } are diagonal we see that U {\displaystyle U} must contain the eigenvectors of X X T {\displaystyle XX^{T}} , while V {\displaystyle V} must be the eigenvectors of X T X {\displaystyle X^{T}X} . Both products have the same non-zero eigenvalues, given by the non-zero entries of Σ Σ T {\displaystyle \Sigma \Sigma ^{T}} , or equally, by the non-zero entries of Σ T Σ {\displaystyle \Sigma ^{T}\Sigma } . Now the decomposition looks like this: X U Σ V T ( d j ) ( d ^ j ) ↓ ↓ ( t i T ) → [ x 1 , 1 … x 1 , j … x 1 , n ⋮ ⋱ ⋮ ⋱ ⋮ x i , 1 … x i , j … x i , n ⋮ ⋱ ⋮ ⋱ ⋮ x m , 1 … x m , j … x m , n ] = ( t ^ i T ) → [ [ u 1 ] … [ u l ] ] ⋅ [ σ 1 … 0 ⋮ ⋱ ⋮ 0 … σ l ] ⋅ [ [ v 1 ] ⋮ [ v l ] ] {\displaystyle {\begin{matrix}&X&&&U&&\Sigma &&V^{T}\\&({\textbf {d}}_{j})&&&&&&&({\hat {\textbf {d}}}_{j})\\&\downarrow &&&&&&&\downarrow \\({\textbf {t}}_{i}^{T})\rightarrow &{\begin{bmatrix}x_{1,1}&\dots &x_{1,j}&\dots &x_{1,n}\\\vdots &\ddots &\vdots &\ddots &\vdots \\x_{i,1}&\dots &x_{i,j}&\dots &x_{i,n}\\\vdots &\ddots &\vdots &\ddots &\vdots \\x_{m,1}&\dots &x_{m,j}&\dots &x_{m,n}\\\end{bmatrix}}&=&({\hat {\textbf {t}}}_{i}^{T})\rightarrow &{\begin{bmatrix}{\begin{bmatrix}\,\\\,\\{\textbf {u}}_{1}\\\,\\\,\end{bmatrix}}\dots {\begin{bmatrix}\,\\\,\\{\textbf {u}}_{l}\\\,\\\,\end{bmatrix}}\end{bmatrix}}&\cdot &{\begin{bmatrix}\sigma _{1}&\dots &0\\\vdots &\ddots &\vdots \\0&\dots &\sigma _{l}\\\end{bmatrix}}&\cdot &{\begin{bmatrix}{\begin{bmatrix}&&{\textbf {v}}_{1}&&\end{bmatrix}}\\\vdots \\{\begin{bmatrix}&&{\textbf {v}}_{l}&&\end{bmatrix}}\end{bmatrix}}\end{matrix}}} The values σ 1 , … , σ l {\displaystyle \sigma _{1},\dots ,\sigma _{l}} are called the singular values, and u 1 , … , u l {\displaystyle u_{1},\dots ,u_{l}} and v 1 , … , v l {\displaystyle v_{1},\dots ,v_{l}} the left and right singular vectors. Notice the only part of U {\displaystyle U} that contributes to t i {\displaystyle {\textbf {t}}_{i}} is the i 'th {\displaystyle i{\textrm {'th}}} row. Let this row vector be called t ^ i T {\displaystyle {\hat {\textrm {t}}}_{i}^{T}} . Likewise, the only part of V T {\displaystyle V^{T}} that contributes to d j {\displaystyle {\textbf {d}}_{j}} is the j 'th {\displaystyle j{\textrm {'th}}} column, d ^ j {\displaystyle {\hat {\textrm {d}}}_{j}} . These are not the eigenvectors, but depend on all the eigenvectors. I

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  BL (logic)

  In mathematical logic, basic fuzzy logic (or shortly BL), the logic of the continuous t-norms, is one of the t-norm fuzzy logics. It belongs to the broader class of substructural logics, or logics of residuated lattices; it extends the logic MTL of all left-continuous t-norms. == Syntax == === Language === The language of the propositional logic BL consists of countably many propositional variables and the following primitive logical connectives: Implication → {\displaystyle \rightarrow } (binary) Strong conjunction ⊗ {\displaystyle \otimes } (binary). The sign & is a more traditional notation for strong conjunction in the literature on fuzzy logic, while the notation ⊗ {\displaystyle \otimes } follows the tradition of substructural logics. Bottom ⊥ {\displaystyle \bot } (nullary — a propositional constant); 0 {\displaystyle 0} or 0 ¯ {\displaystyle {\overline {0}}} are common alternative signs and zero a common alternative name for the propositional constant (as the constants bottom and zero of substructural logics coincide in MTL). The following are the most common defined logical connectives: Weak conjunction ∧ {\displaystyle \wedge } (binary), also called lattice conjunction (as it is always realized by the lattice operation of meet in algebraic semantics). Unlike MTL and weaker substructural logics, weak conjunction is definable in BL as A ∧ B ≡ A ⊗ ( A → B ) {\displaystyle A\wedge B\equiv A\otimes (A\rightarrow B)} Negation ¬ {\displaystyle \neg } (unary), defined as ¬ A ≡ A → ⊥ {\displaystyle \neg A\equiv A\rightarrow \bot } Equivalence ↔ {\displaystyle \leftrightarrow } (binary), defined as A ↔ B ≡ ( A → B ) ∧ ( B → A ) {\displaystyle A\leftrightarrow B\equiv (A\rightarrow B)\wedge (B\rightarrow A)} As in MTL, the definition is equivalent to ( A → B ) ⊗ ( B → A ) . {\displaystyle (A\rightarrow B)\otimes (B\rightarrow A).} (Weak) disjunction ∨ {\displaystyle \vee } (binary), also called lattice disjunction (as it is always realized by the lattice operation of join in algebraic semantics), defined as A ∨ B ≡ ( ( A → B ) → B ) ∧ ( ( B → A ) → A ) {\displaystyle A\vee B\equiv ((A\rightarrow B)\rightarrow B)\wedge ((B\rightarrow A)\rightarrow A)} Top ⊤ {\displaystyle \top } (nullary), also called one and denoted by 1 {\displaystyle 1} or 1 ¯ {\displaystyle {\overline {1}}} (as the constants top and zero of substructural logics coincide in MTL), defined as ⊤ ≡ ⊥ → ⊥ {\displaystyle \top \equiv \bot \rightarrow \bot } Well-formed formulae of BL are defined as usual in propositional logics. In order to save parentheses, it is common to use the following order of precedence: Unary connectives (bind most closely) Binary connectives other than implication and equivalence Implication and equivalence (bind most loosely) === Axioms === A Hilbert-style deduction system for BL has been introduced by Petr Hájek (1998). Its single derivation rule is modus ponens: from A {\displaystyle A} and A → B {\displaystyle A\rightarrow B} derive B . {\displaystyle B.} The following are its axiom schemata: ( B L 1 ) : ( A → B ) → ( ( B → C ) → ( A → C ) ) ( B L 2 ) : A ⊗ B → A ( B L 3 ) : A ⊗ B → B ⊗ A ( B L 4 ) : A ⊗ ( A → B ) → B ⊗ ( B → A ) ( B L 5 a ) : ( A → ( B → C ) ) → ( A ⊗ B → C ) ( B L 5 b ) : ( A ⊗ B → C ) → ( A → ( B → C ) ) ( B L 6 ) : ( ( A → B ) → C ) → ( ( ( B → A ) → C ) → C ) ( B L 7 ) : ⊥ → A {\displaystyle {\begin{array}{ll}{\rm {(BL1)}}\colon &(A\rightarrow B)\rightarrow ((B\rightarrow C)\rightarrow (A\rightarrow C))\\{\rm {(BL2)}}\colon &A\otimes B\rightarrow A\\{\rm {(BL3)}}\colon &A\otimes B\rightarrow B\otimes A\\{\rm {(BL4)}}\colon &A\otimes (A\rightarrow B)\rightarrow B\otimes (B\rightarrow A)\\{\rm {(BL5a)}}\colon &(A\rightarrow (B\rightarrow C))\rightarrow (A\otimes B\rightarrow C)\\{\rm {(BL5b)}}\colon &(A\otimes B\rightarrow C)\rightarrow (A\rightarrow (B\rightarrow C))\\{\rm {(BL6)}}\colon &((A\rightarrow B)\rightarrow C)\rightarrow (((B\rightarrow A)\rightarrow C)\rightarrow C)\\{\rm {(BL7)}}\colon &\bot \rightarrow A\end{array}}} The axioms (BL2) and (BL3) of the original axiomatic system were shown to be redundant (Chvalovský, 2012) and (Cintula, 2005). All the other axioms were shown to be independent (Chvalovský, 2012). == Semantics == Like in other propositional t-norm fuzzy logics, algebraic semantics is predominantly used for BL, with three main classes of algebras with respect to which the logic is complete: General semantics, formed of all BL-algebras — that is, all algebras for which the logic is sound Linear semantics, formed of all linear BL-algebras — that is, all BL-algebras whose lattice order is linear Standard semantics, formed of all standard BL-algebras — that is, all BL-algebras whose lattice reduct is the real unit interval [0, 1] with the usual order; they are uniquely determined by the function that interprets strong conjunction, which can be any continuous t-norm.

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  Clinical decision support system

  A clinical decision support system (CDSS) is a form of health information technology that provides clinicians, staff, patients, or other individuals with knowledge and person-specific information to enhance decision-making in clinical workflows. CDSS tools include alerts and reminders, clinical guidelines, condition-specific order sets, patient data summaries, diagnostic support, and context-aware reference information. They often leverage artificial intelligence to analyze clinical data and help improve care quality and safety. CDSSs constitute a major topic in artificial intelligence in medicine. == Characteristics == A clinical decision support system is an active knowledge system that uses variables of patient data to produce advice regarding health care. This implies that a CDSS is simply a decision support system focused on using knowledge management. === Purpose === The main purpose of modern CDSS is to assist clinicians at the point of care. This means that clinicians interact with a CDSS to help to analyze and reach a diagnosis based on patient data for different diseases. In the early days, CDSSs were conceived to make decisions for the clinician in a literal manner. The clinician would input the information and wait for the CDSS to output the "right" choice, and the clinician would simply act on that output. However, the modern methodology of using CDSSs to assist means that the clinician interacts with the CDSS, utilizing both their knowledge and the CDSS's, better to analyse the patient's data than either a human or a CDSS could do on their own. Typically, a CDSS makes suggestions for the clinician to review, and the clinician is expected to pick out useful information from the presented results and discount erroneous CDSS suggestions. The two main types of CDSS are knowledge-based systems and non-knowledge-based (machine learning–based) systems: An example of how a clinician might use a clinical decision support system is a diagnosis decision support system (DDSS). DDSS requests some of the patient's data and, in response, proposes a set of possible diagnoses. The physician then takes the output of the DDSS and determines which diagnoses are likely and which are not, and, if necessary, orders further tests to narrow down the diagnosis. Another example of a CDSS would be a case-based reasoning (CBR) system. A CBR system might use previous case data to help determine the appropriate amount of beams and the optimal beam angles for use in radiotherapy for brain cancer patients; medical physicists and oncologists would then review the recommended treatment plan to determine its viability. Another important classification of a CDSS is based on the timing of its use. Physicians use these systems at the point of care to help them as they are dealing with a patient, with the timing of use being either pre-diagnosis, during diagnosis, or post-diagnosis. Pre-diagnosis CDSS systems help the physician prepare the diagnoses. CDSSs help review and filter the physician's preliminary diagnostic choices to improve outcomes. Post-diagnosis CDSS systems are used to mine data to derive connections between patients and their past medical history and clinical research to predict future events. Early speculation that AI-based decision support would replace clinicians in common tasks has largely given way to a consensus around assistive models, in which AI augments rather than supplants clinical judgment. Contemporary deep learning-based systems, unlike earlier rule-based tools, can be trained directly on clinical data without manual rule authoring and integrated into electronic health record workflows at the point of care. Another approach, used by the National Health Service in England, is to use a CDSS to triage medical conditions out of hours by suggesting a suitable next step to the patient (e.g. call an ambulance, or see a general practitioner on the next working day). The suggestion, which may be disregarded by either the patient or the phone operative if common sense or caution suggests otherwise, is based on the known information and an implicit conclusion about what the worst-case diagnosis is likely to be; it is not always revealed to the patient because it might well be incorrect and is not based on a medically-trained person's opinion - it is only used for initial triage purposes. === Knowledge-based === Most CDSSs consist of three parts: the knowledge base, an inference engine, and a mechanism to communicate. The knowledge base contains the rules and associations of compiled data which most often take the form of IF-THEN rules. If this was a system for determining drug interactions, then a rule might be that IF drug X is taken AND drug Y is taken THEN alert the user. Using another interface, an advanced user could edit the knowledge base to keep it up to date with new drugs. The inference engine combines the rules from the knowledge base with the patient's data. The communication mechanism allows the system to show the results to the user as well as have input into the system. An expression language such as GELLO or CQL (Clinical Quality Language) is needed for expressing knowledge artefacts in a computable manner. For example: if a patient has diabetes mellitus, and if the last haemoglobin A1c test result was less than 7%, recommend re-testing if it has been over six months, but if the last test result was greater than or equal to 7%, then recommend re-testing if it has been over three months. The current focus of the HL7 CDS WG is to build on the Clinical Quality Language (CQL). The U.S. Centers for Medicare & Medicaid Services (CMS) has announced that it plans to use CQL for the specification of Electronic Clinical Quality Measures (eCQMs). === Non-knowledge-based === CDSSs which do not use a knowledge base use a form of artificial intelligence called machine learning, which allow computers to learn from past experiences and/or find patterns in clinical data. This eliminates the need for writing rules and expert input. However, since systems based on machine learning cannot explain the reasons for their conclusions, most clinicians do not use them directly for diagnoses, reliability and accountability reasons. Nevertheless, they can be useful as post-diagnostic systems, for suggesting patterns for clinicians to look into in more depth. As of 2012, three types of non-knowledge-based systems are support-vector machines, artificial neural networks and genetic algorithms. Artificial neural networks use nodes and weighted connections between them to analyse the patterns found in patient data to derive associations between symptoms and a diagnosis. Genetic algorithms are based on simplified evolutionary processes using directed selection to achieve optimal CDSS results. The selection algorithms evaluate components of random sets of solutions to a problem. The solutions that come out on top are then recombined and mutated and run through the process again. This happens over and over until the proper solution is discovered. They are functionally similar to neural networks in that they are also "black boxes" that attempt to derive knowledge from patient data. Non-knowledge-based networks often focus on a narrow list of symptoms, such as symptoms for a single disease, as opposed to the knowledge-based approach, which covers the diagnosis of many diseases. An example of a non-knowledge-based CDSS is a web server developed using a support vector machine for the prediction of gestational diabetes in Ireland. == Regulations == === History, United States === The IOM had published a report in 1999, To Err is Human, which focused on the patient safety crisis in the United States, pointing to the incredibly high number of deaths. This statistic attracted great attention to the quality of patient care. The Institute of Medicine (IOM) promoted the usage of health information technology, including clinical decision support systems, to advance the quality of patient care. With the enactment of the American Recovery and Reinvestment Act of 2009 (ARRA), there was a push for widespread adoption of health information technology through the Health Information Technology for Economic and Clinical Health Act (HITECH). Through these initiatives, more hospitals and clinics were integrating electronic medical records (EMRs) and computerized physician order entry (CPOE) within their health information processing and storage. Despite the absence of laws, the CDSS vendors would almost certainly be viewed as having a legal duty of care to both the patients who may adversely be affected due to CDSS usage and the clinicians who may use the technology for patient care. However, duties of care legal regulations are not explicitly defined yet. With the enactment of the HITECH Act included in the ARRA, encouraging the adoption of health IT, more detailed case laws for CDSS and EMRs were still being defined by the Office of National Coordinator for Health Informati

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  Resistance Database Initiative

  HIV Resistance Response Database Initiative (RDI) was formed in 2002 to use artificial intelligence (AI) to predict how patients will respond to HIV drugs using data from more 250,000 patients from around 50 countries around the world. The RDI used its models to power its HIV Treatment Response Prediction System (HIV-TRePS). Launched in 2010, this free online tool enabled healthcare professionals to upload their patient’s data and obtain highly accurate predictions of how they would respond to different combinations of the 30 or more drugs available. The tool enabled physicians to individualize their patients’ treatment, using these predictions based on more than a million patient-years of treatment experience. HIV-TRePS was possibly the first ever AI-based system for medical decision-making to be developed, successfully tested, and used in clinical practice. It has since been used by thousands of healthcare professionals to optimise the treatment of tens of thousands of patients. Since the RDI’s inception the treatment of HIV infection has progressed enormously, with more effective and better tolerated drugs available in ever more convenient combination formulations. In most countries HIV is now considered a chronic, manageable condition. Moreover, the success of the drugs in reducing the amount of virus is substantially reducing the onward transmission of the virus and cases of new infections are falling in many settings. This improvement in HIV treatment means the need for sophisticated AI to support HIV treatment decisions has significantly reduced. In response, the RDI ceased development of further models and, in March 2024, withdrew its HIV-TRePS system. == Background == Human immunodeficiency virus (HIV) is the virus that causes acquired immunodeficiency syndrome (AIDS), a condition in which the immune system begins to fail, leading to life-threatening opportunistic infections. There are approximately 30 HIV antiretroviral drugs that have been approved for the treatment of HIV infection, from six different classes, based on the point in the HIV life-cycle at which they act. They are used in combination; typically 3 or more drugs from 2 or more different classes, a form of therapy known as highly active antiretroviral therapy (HAART). The aim of therapy is to suppress the virus to very low, ideally undetectable, levels in the blood. This prevents the virus from depleting the immune cells that it preferentially attacks CD4 cells and prevents or delays illness and death. Despite the expanding availability of these drugs and the impact of their use, treatments continue to fail, often involving to the development of resistance. During drug therapy, low-level virus replication may still occur, particularly when a patient misses a dose. HIV makes errors in copying its genetic material and, if a mutation makes the virus resistant to one or more of the drugs in the patient's treatment, it may begin to replicate more successfully in the presence of that drug and undermine the effect of the treatment. If this happens, the treatment needs to be changed to re-establish control over the virus. == RDI's Approach == The RDI’s approach was to use artificial intelligence (including neural network and random forest models), trained with data from hundreds of thousands of patients, treated with different drugs in a variety of clinical settings all over the world, to predict how an individual patient will respond to any new combination of HIV drugs. The models were tested with independent data sets and consistently achieved accuracy of approximately 80%.

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  ISPConfig

  ISPConfig is an open source hosting control panel for Linux, licensed under BSD license and developed by the company ISPConfig UG. The ISPConfig project was started in autumn 2005 by Till Brehm from the German company projektfarm GmbH. == Overview == Using the dashboard, administrators have the ability to manage websites, email addresses, MySQL and MariaDB as well as PostgreSQL (since version 3.3) databases, FTP accounts, Shell accounts and DNS records through a web-based interface. The software has 4 login levels: administrator, reseller, client, and email-user, each with a different set of permissions. == Operating Systems == ISPConfig is only available on Linux, with CentOS, Debian, and Ubuntu being among the supported distributions. == Features == The following services and features are supported: Management of a single or multiple servers from one control panel. Web server management for Apache HTTP Server and Nginx. Mail server management (with virtual mail users) with spam and antivirus filter using Postfix (software) and Dovecot (software). DNS server management (BIND, Powerdns). Configuration mirroring and clusters. Administrator, reseller, client and mail-user login. Virtual server management for OpenVZ Servers. Website statistics using Webalizer and AWStats

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  The MANIAC

  The MANIAC is a 2023 novel by Chilean author Benjamín Labatut, written in English. It is a fictionalised biography of polymath John von Neumann, whom Labatut calls "the smartest human being of the 20th century". The book focuses on von Neumann, but is also about physicist Paul Ehrenfest, the history of artificial intelligence, and Lee Sedol's Go match against AlphaGo. The book received mostly positive reviews from critics. == Background == John von Neumann was a Jewish Hungarian-born polymath who was a prodigy from an early childhood. Von Neumann worked in multiple fields of science, theoretical (mathematical foundations of quantum mechanics, game theory, cellular automata) and applied (nuclear weapons research during the Manhattan Project in World War II, computer architecture later named after him, and many other subjects). Labatut calls him "the smartest human being of the 20th century". The title of the book is derived from an early computer based on von Neumann architecture, built after the war at Los Alamos laboratory, called MANIAC I. Benjamín Labatut is a Chilean author known for his 2020 book When We Cease to Understand the World, a collection of fictionalised stories about famous scientists that received positive reviews and was translated into multiple languages from Spanish. The MANIAC is Labatut's first book written in English. In an interview, Labatut said he prefers to write in English: English is my preferred form of thought. ... English is the language I do most if not all my reading it. And it is a far better language than Spanish, in so many ways. Writing "clean" prose in Spanish is almost impossible, because so many of its sounds clash. Borges said that he found English "a far finer language than Spanish" because it's both Germanic and Latin; because of its wonderful vocabulary ("Regal is not exactly the same thing as saying kingly," he explained); because of its physicality; and because you can do almost anything with verbs and prepositions. Labatut was inspired to write The MANIAC by George Dyson's book Turing's Cathedral. == Synopsis == The book has three chapters. The first chapter, "Paul or the Discovery of the Irrational", written in the third person, is about physicist Paul Ehrenfest. The chapter opens with Ehrenfest shooting dead his son Vassily, who suffered from Down syndrome, and then himself. It then recounts Ehrenfest's life story, describing his relationships with his wife Tatyana, his mistress Nelly Meyjes, and his eminent physicist colleagues. It chronicles his descent into despair and depression over his marriage's disintegration, the advent of quantum mechanics, and the direction Europe was heading in with the Nazi Party's rise to power in Germany, looping back to the initial scene of the chapter. The second chapter, "John or the Mad Dreams of Reason", is about John von Neumann, and is written as a series of interviews of his family members, wives, friends, and colleagues, each in a distinctive voice. It is divided into three parts. Part I, "The Limits of Logic", is about his early life, as told by von Neumann's childhood friend Eugene Wigner, mother Margrit Kann, brother Nicholas von Neumann, first wife Mariette Kövesi, and scientists Theodore von Karman, George Polya, and Gábor Szegő. It climaxes with von Neumann's participation in David Hilbert's program to create a logical basis for mathematics based on a consistent set of axioms, a quest ultimately scuppered by Kurt Gödel. Part II, "The Delicate Balance of Terror", discusses von Neumann's role in the Manhattan Project (as told by Richard Feynman); his development of game theory and the doctrine of mutual assured destruction (MAD) (as told by Oskar Morgenstern); and his creation of the MANIAC I computer and the von Neumann architecture (as told by Julian Bigelow). In Part III, "Ghosts in the Machine", Sydney Brenner discusses von Neumann's contributions to biology, his theoretical work on self-replicating and self-repairing machines, and his vision of Von Neumann probes exploring the universe. Nils Aall Barricelli talks about his ideas of digital life and his disagreements with von Neumann. Von Neumann's wife Klára Dán, daughter Marina, and Wigner talk about his final years, personal life, and death. The third chapter, "Lee or The Delusions of Artificial Intelligence", is about Lee Sedol's Go match against AlphaGo. The narrative reverts to the third person. The chapter also tells the story of Demis Hassabis, a chess prodigy in childhood who decided to work on artificial intelligence and founded DeepMind, the company behind AlphaGo. The way is pointed to the future, as artificial intelligence's growing capabilities outpace the human mind. The book ends with Lee Sedol's retirement from Go, and new version of DeepMind's program, AlphaZero, that did not train on human games but nevertheless became the strongest player in Go, chess, and Shogi. == Reception == The book received mostly positive reviews. In his review for The New York Times Tom McCarthy noted the ambiguity of genre: "At its best, as in the stunning opening sequence reconstructing the murder-suicide of the physicist Paul Ehrenfest and his disabled son, or in the final section's gripping account of a computer defeating the world's best human Go player, you just throw up your hands and think, Who cares what discourse label we assign this stuff? It's great." Becca Rothfeld of the Washington Post praised the book, writing that it is "Labatut's latest virtuosic effort, at once a historical novel and a philosophical foray": "The MANIAC is a work of dark, eerie and singular beauty." She noted that the book "can also be difficult to read" because of its unusual narrative structure: "The book is narrated by a cluttered polyphony of characters, among them both of von Neumann's wives and a number of his teachers and colleagues. ... Like von Neumann, The MANIAC strives to adopt the impartial standpoint of the universe." Killian Fox of The Guardian sees the book as "darkly fascinating novel", and notes Labatut's "impressive dexterity, unpicking complex ideas in long, elegant sentences that propel us forward at speed (this is his first book written in English). Even in the more feverish passages, when yet another great mind succumbs to madness, haunted by the spectres they've helped unleash on the world, he feels in full control of his material." Sam Byers of The Guardian praises the book and the author's style: "The opening chapter of Benjamín Labatut's second novel is such a perfect distillation of his technique that it could serve as a manifesto." and "Readers ... will recognise the sense of breathlessness his best writing can evoke. Seemingly loosened from the laws of physics they describe, his sentences range freely through time and space, connecting not only characters and events, but the delicate tissue of intellectual history, often with a lightness of touch that belies their underlying complexity." He writes on the narrative structure: "Through a cascade of staccato chapters, an ensemble of narrators offer their piecemeal insights." Byers adds that "a brilliant novel is not quite what we end up with" and sees the problem in the "diffusion": "Labatut simply spreads himself too thin. Too many years in too few pages; too many voices with far too little to distinguish them. Initially intriguing, the bite-size monologues quickly come to feel inadequate." Some reviewers did not see the book as a biography. In an essay for the Cleveland Review of Books, Ben Cosman juxtaposes the book with Christopher Nolan's biopic Oppenheimer, and writes that it "follows the development of artificial intelligence—first as an idea at the beginning of the twentieth century, and then as a practicality at the beginning of the twenty-first—through the lives of three men who faced it." He also compared the book's structure to "witness testimony". Another reviewer called the book "perfect for anyone thirsting for more nuclear anxiety after watching Oppenheimer". Garrett Biggs of the Chicago Review of Books writes of the book's style: "Labatut writes about scientists the way Roberto Bolaño writes about poets. They are near mythical figures, captured at the corner of the novel's eye. They become historical in the most fraught sense of the term: subject to rumor and speculation and, eventually, the novel's form inflates their personas into something so large they can only be understood as narrative, never known in any objective capacity." Biggs criticises the last chapter: "the story of artificial intelligence has yet to be written. And so when Labatut's narration editorializes about artificial intelligence as 'a future that inspires hope and horror,' The MANIAC disassembles as a novel and starts to sound like a stale thinkpiece. AlphaGo might represent the first glimmer of a true artificial intelligence, as Labatut suggests. It also could one day be considered nothing more than a souped-up cousin to IBM's DeepBlue.

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  Conference on Neural Information Processing Systems

  The Conference on Neural Information Processing Systems (abbreviated as NeurIPS and formerly NIPS) is a machine learning and computational neuroscience conference held annually in December. Along with ICLR and ICML, it is one of the three primary conferences of high impact in machine learning and artificial intelligence research. The conference includes three days of invited talks along with oral and poster presentations of refereed papers, followed by two days of workshops and competitions. == History == The NeurIPS meeting was first proposed in 1986 at the annual invitation-only Snowbird Meeting on Neural Networks for Computing organized by The California Institute of Technology and Bell Laboratories. NeurIPS was designed as a complementary open interdisciplinary meeting for researchers exploring biological and artificial Neural Networks. Reflecting this multidisciplinary approach, NeurIPS began in 1987 with information theorist Ed Posner as the conference president and learning theorist Yaser Abu-Mostafa as program chairman. Research presented in the early NeurIPS meetings included a wide range of topics from efforts to solve purely engineering problems to the use of computer models as a tool for understanding biological nervous systems. Since then, the biological and artificial systems research streams have diverged, and recent NeurIPS proceedings have been dominated by papers on machine learning, artificial intelligence and statistics. From 1987 until 2000 NeurIPS was held in Denver, United States. Since then, the conference was held in Vancouver, Canada (2001–2010), Granada, Spain (2011), and Lake Tahoe, United States (2012–2013). In 2014 and 2015, the conference was held in Montreal, Canada, in Barcelona, Spain in 2016, in Long Beach, United States in 2017, in Montreal, Canada in 2018 and Vancouver, Canada in 2019. Reflecting its origins at Snowbird, Utah, the meeting was accompanied by workshops organized at a nearby ski resort up until 2013, when it outgrew ski resorts. The first NeurIPS Conference was sponsored by the IEEE. The following NeurIPS Conferences have been organized by the NeurIPS Foundation, established by Ed Posner. Terrence Sejnowski has been the president of the NeurIPS Foundation since Posner's death in 1993. The board of trustees consists of previous general chairs of the NeurIPS Conference. The first proceedings was published in book form by the American Institute of Physics in 1987, and was entitled Neural Information Processing Systems, then the proceedings from the following conferences have been published by Morgan Kaufmann (1988–1993), MIT Press (1994–2004) and Curran Associates (2005–present) under the name Advances in Neural Information Processing Systems. The conference was originally abbreviated as "NIPS". By 2018 a few commentators were criticizing the abbreviation as encouraging sexism due to its association with the word nipples, and as being a slur against Japanese. The board changed the abbreviation to "NeurIPS" in November 2018. == Topics == Along with machine learning and neuroscience, other fields represented at NeurIPS include cognitive science, psychology, computer vision, statistical linguistics, and information theory. Over the years, NeurIPS became a premier conference on machine learning and although the 'Neural' in the NeurIPS acronym had become something of a historical relic, the resurgence of deep learning in neural networks since 2012, fueled by faster computers and big data, has led to achievements in speech recognition, object recognition in images, image captioning, language translation and world championship performance in the game of Go, based on neural architectures inspired by the hierarchy of areas in the visual cortex (ConvNet) and reinforcement learning inspired by the basal ganglia (Temporal difference learning). Notable affinity groups have emerged from the NeurIPS conference and displayed diversity, including Black in AI (in 2017), Queer in AI (in 2016), and others. === Named lectures === In addition to invited talks and symposia, NeurIPS also organizes two named lectureships to recognize distinguished researchers. The NeurIPS Board introduced the Posner Lectureship in honor of NeurIPS founder Ed Posner; two Posner Lectures were given each year up to 2015. Past lecturers have included: 2010 – Josh Tenenbaum and Michael I. Jordan 2011 – Rich Sutton and Bernhard Schölkopf 2012 – Thomas Dietterich and Terry Sejnowski 2013 – Daphne Koller and Peter Dayan 2014 – Michael Kearns and John Hopfield 2015 – Zoubin Ghahramani and Vladimir Vapnik 2016 – Yann LeCun 2017 – John Platt 2018 – Joëlle Pineau 2019 – Yoshua Bengio 2020 – Christopher Bishop 2021 – Peter Bartlett In 2015, the NeurIPS Board introduced the Breiman Lectureship to highlight work in statistics relevant to conference topics. The lectureship was named for statistician Leo Breiman, who served on the NeurIPS Board from 1994 to 2005. Past lecturers have included: 2015 – Robert Tibshirani 2016 – Susan Holmes 2017 – Yee Whye Teh 2018 – David Spiegelhalter 2019 – Bin Yu 2020 – Marloes Maathuis 2021 – Gabor Lugosi 2022 – Emmanuel Candes 2023 – Susan Murphy 2024 – Arnaud Doucet == NeurIPS consistency experiment == In NIPS 2014, the program chairs duplicated 10% of all submissions and sent them through separate reviewers to evaluate randomness in the reviewing process. Several researchers interpreted the result. Regarding whether the decision in NIPS is completely random or not, John Langford writes: "Clearly not—a purely random decision would have arbitrariness of ~78%. It is, however, quite notable that 60% is much closer to 78% than 0%." He concludes that the result of the reviewing process is mostly arbitrary. In NeurIPS 2021, the program chairs repeated the 2014 experiment and found similar levels of review inconsistency; 23% of duplicated submissions received different accept/reject decisions, and 50.6% of accepted papers would have been rejected under re-review. == Locations == 1987–2000: Denver, Colorado, United States 2001–2010: Vancouver, British Columbia, Canada 2011: Granada, Spain 2012 & 2013: Stateline, Nevada, United States 2014 & 2015: Montréal, Quebec, Canada 2016: Barcelona, Spain 2017: Long Beach, California, United States 2018: Montréal, Quebec, Canada 2019: Vancouver, British Columbia, Canada 2020: Vancouver, British Columbia, Canada (virtual conference) 2021: Virtual conference 2022 & 2023: New Orleans, Louisiana, United States 2024: Vancouver, British Columbia, Canada 2025: San Diego, California, United States and Mexico City, Mexico 2026: Sydney, New South Wales, Australia, with satellite events in Atlanta and Paris

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  Gene expression programming

  Gene expression programming (GEP) in computer programming is an evolutionary algorithm that creates computer programs or models. These computer programs are complex tree structures that learn and adapt by changing their sizes, shapes, and composition, much like a living organism. And like living organisms, the computer programs of GEP are also encoded in simple linear chromosomes of fixed length. Thus, GEP is a genotype–phenotype system, benefiting from a simple genome to keep and transmit the genetic information and a complex phenotype to explore the environment and adapt to it. == Background == Evolutionary algorithms use populations of individuals, select individuals according to fitness, and introduce genetic variation using one or more genetic operators. Their use in artificial computational systems dates back to the 1950s where they were used to solve optimization problems (e.g. Box 1957 and Friedman 1959). But it was with the introduction of evolution strategies by Rechenberg in 1965 that evolutionary algorithms gained popularity. A good overview text on evolutionary algorithms is the book "An Introduction to Genetic Algorithms" by Mitchell (1996). Gene expression programming belongs to the family of evolutionary algorithms and is closely related to genetic algorithms and genetic programming. From genetic algorithms it inherited the linear chromosomes of fixed length; and from genetic programming it inherited the expressive parse trees of varied sizes and shapes. In gene expression programming the linear chromosomes work as the genotype and the parse trees as the phenotype, creating a genotype/phenotype system. This genotype/phenotype system is multigenic, thus encoding multiple parse trees in each chromosome. This means that the computer programs created by GEP are composed of multiple parse trees. Because these parse trees are the result of gene expression, in GEP they are called expression trees. Masood Nekoei, et al. utilized this expression programming style in ABC optimization to conduct ABCEP as a method that outperformed other evolutionary algorithms.ABCEP == Encoding: the genotype == The genome of gene expression programming consists of a linear, symbolic string or chromosome of fixed length composed of one or more genes of equal size. These genes, despite their fixed length, code for expression trees of different sizes and shapes. An example of a chromosome with two genes, each of size 9, is the string (position zero indicates the start of each gene): 012345678012345678 L+a-baccdcLabacd where “L” represents the natural logarithm function and “a”, “b”, “c”, and “d” represent the variables and constants used in a problem. == Expression trees: the phenotype == As shown above, the genes of gene expression programming have all the same size. However, these fixed length strings code for expression trees of different sizes. This means that the size of the coding regions varies from gene to gene, allowing for adaptation and evolution to occur smoothly. For example, the mathematical expression: ( a − b ) ( c + d ) {\displaystyle {\sqrt {(a-b)(c+d)}}\,} can also be represented as an expression tree: where "Q” represents the square root function. This kind of expression tree consists of the phenotypic expression of GEP genes, whereas the genes are linear strings encoding these complex structures. For this particular example, the linear string corresponds to: 01234567 Q-+abcd which is the straightforward reading of the expression tree from top to bottom and from left to right. These linear strings are called k-expressions (from Karva notation). Going from k-expressions to expression trees is also very simple. For example, the following k-expression: 01234567890 Qb+baQba is composed of two different terminals (the variables “a” and “b”), two different functions of two arguments (“” and “+”), and a function of one argument (“Q”). Its expression gives: == K-expressions and genes == The k-expressions of gene expression programming correspond to the region of genes that gets expressed. This means that there might be sequences in the genes that are not expressed, which is indeed true for most genes. The reason for these noncoding regions is to provide a buffer of terminals so that all k-expressions encoded in GEP genes correspond always to valid programs or expressions. The genes of gene expression programming are therefore composed of two different domains – a head and a tail – each with different properties and functions. The head is used mainly to encode the functions and variables chosen to solve the problem at hand, whereas the tail, while also used to encode the variables, provides essentially a reservoir of terminals to ensure that all programs are error-free. For GEP genes the length of the tail is given by the formula: t = h ( n max − 1 ) + 1 {\displaystyle t=h(n_{\max }-1)+1} where h is the head's length and nmax is maximum arity. For example, for a gene created using the set of functions F = {Q, +, −, ∗, /} and the set of terminals T = {a, b}, nmax = 2. And if we choose a head length of 15, then t = 15 (2–1) + 1 = 16, which gives a gene length g of 15 + 16 = 31. The randomly generated string below is an example of one such gene: 0123456789012345678901234567890 b+a-aQab+//+b+babbabbbababbaaa It encodes the expression tree: which, in this case, only uses 8 of the 31 elements that constitute the gene. It's not hard to see that, despite their fixed length, each gene has the potential to code for expression trees of different sizes and shapes, with the simplest composed of only one node (when the first element of a gene is a terminal) and the largest composed of as many nodes as there are elements in the gene (when all the elements in the head are functions with maximum arity). It's also not hard to see that it is trivial to implement all kinds of genetic modification (mutation, inversion, insertion, recombination, and so on) with the guarantee that all resulting offspring encode correct, error-free programs. == Multigenic chromosomes == The chromosomes of gene expression programming are usually composed of more than one gene of equal length. Each gene codes for a sub-expression tree (sub-ET) or sub-program. Then the sub-ETs can interact with one another in different ways, forming a more complex program. The figure shows an example of a program composed of three sub-ETs. In the final program the sub-ETs could be linked by addition or some other function, as there are no restrictions to the kind of linking function one might choose. Some examples of more complex linkers include taking the average, the median, the midrange, thresholding their sum to make a binomial classification, applying the sigmoid function to compute a probability, and so on. These linking functions are usually chosen a priori for each problem, but they can also be evolved elegantly and efficiently by the cellular system of gene expression programming. == Cells and code reuse == In gene expression programming, homeotic genes control the interactions of the different sub-ETs or modules of the main program. The expression of such genes results in different main programs or cells, that is, they determine which genes are expressed in each cell and how the sub-ETs of each cell interact with one another. In other words, homeotic genes determine which sub-ETs are called upon and how often in which main program or cell and what kind of connections they establish with one another. === Homeotic genes and the cellular system === Homeotic genes have exactly the same kind of structural organization as normal genes and they are built using an identical process. They also contain a head domain and a tail domain, with the difference that the heads contain now linking functions and a special kind of terminals – genic terminals – that represent the normal genes. The expression of the normal genes results as usual in different sub-ETs, which in the cellular system are called ADFs (automatically defined functions). As for the tails, they contain only genic terminals, that is, derived features generated on the fly by the algorithm. For example, the chromosome in the figure has three normal genes and one homeotic gene and encodes a main program that invokes three different functions a total of four times, linking them in a particular way. From this example it is clear that the cellular system not only allows the unconstrained evolution of linking functions but also code reuse. And it shouldn't be hard to implement recursion in this system. === Multiple main programs and multicellular systems === Multicellular systems are composed of more than one homeotic gene. Each homeotic gene in this system puts together a different combination of sub-expression trees or ADFs, creating multiple cells or main programs. For example, the program shown in the figure was created using a cellular system with two cells and three normal genes. The applications of these multicellular systems are mu

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  Clapper (service)

  Clapper is an American short-form video-hosting service headquartered in Dallas, Texas. It was founded in 2020 by Edison Chen as an alternative for TikTok for mature audiences. The app is functionally similar to TikTok and includes tipping and e-commerce features. Following an influx of far-right content in early 2021, Clapper strengthened its moderation practices. It achieved 2 million monthly active users by 2023, and the number of downloads increased after a U.S. bill that would potentially ban TikTok in the country was signed in 2024. == History == With its offices in Dallas, Texas, Clapper was founded in July 2020 by Chinese-American entrepreneur Edison Chen. Chen considered that most online platforms, such as TikTok, were being targeted to young generations, such as Generation Z. He then concepted Clapper as a service with short-form content for mature audiences among Generation X and millennials, while not intending to compete directly with TikTok. Clapper averaged fewer than ten thousand daily active users during 2020, reaching 500 thousand downloads in the next year. Initially without paying for external advertising, the company raised about $3 million during a 2021 seed funding round. In 2023, the app reportedly reached about 300 to 400 thousand daily active users and 2 million monthly active users. The average user was between the ages of 35 and 55. Following the April 2024 signing of the Protecting Americans from Foreign Adversary Controlled Applications Act, which would potentially enact a ban on TikTok in the U.S. in January 2025, Clapper averaged 200 thousand weekly downloads. In 2025, before the day scheduled for the ban (January 19), TikTok users migrated to other apps. As a result, Clapper received 1.4 million new downloads in a week preceding the date. It was listed as the third most-downloaded free app on Apple's App Store on January 14, behind Xiaohongshu and Lemon8, and the term "TikTok refugee" became a trending term. == Features == Clapper presents similarities with TikTok in its layout, including "Following" and "For You" tabs with videos up to three minutes long that can be liked, commented on or shared. A "Clapback" feature allows users to create responses to videos from others. Users can create livestreams and chat rooms in the app. Users can tip Clapper creators through its Clapper Fam monetization feature, in place of in-app advertisements. The Clapper Shop allows for e-commerce between users. The service had distributed $10 million to its users in total by 2023, according to Clapper CEO Chen. == Content == Clapper includes a policy requiring users to be at least 17 years of age, although Clapper CEO Chen described that "there is no adult content" on the platform. Lindsay Dodgson of Business Insider described the content as generally outdated and "reminiscent of 'getting owned' compilations of the earlier internet." The Washington Post's Tatum Hunter characterized Clapper as including sexual or engagement baiting content more prevalently than TikTok. === Moderation === Clapper's team, which had fifteen employees in early 2021, initially stated it would not moderate content as strictly as TikTok and would mostly rely on user reports. Following that year's January 6 United States Capitol attack, far-right conservative videos promoting QAnon and anti-vaccine conspiracy theories appeared on Clapper's "For You" page to a substantial degree for weeks. The videos were made in protest against decisions by platforms, particularly TikTok, to ban such content. Clapper's team stated in January 10 that its rules prohibiting incitements to violence would be strictly enforced. By February, videos and accounts promoting the conspiracy theories had been removed, and QAnon-related content was banned permanently. Clapper's team hired more content auditors and implemented moderation by artificial intelligence for further community guideline violations.

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  Fuzzy markup language

  Fuzzy Markup Language (FML) is a specific purpose markup language based on XML, used for describing the structure and behavior of a fuzzy system independently of the hardware architecture devoted to host and run it. == Overview == FML was designed and developed by Giovanni Acampora during his Ph.D. course in Computer Science, at University of Salerno, Italy, in 2004. The original idea inspired Giovanni Acampora to create FML was the necessity of creating a cooperative fuzzy-based framework aimed at automatically controlling a living environment characterized by a plethora of heterogeneous devices whose interactions were devoted to maximize the human comfort under energy saving constraints. This framework represented one of the first concrete examples of Ambient Intelligence. Beyond this pioneering application, the major advantage of using XML to describe a fuzzy system is hardware/software interoperability. Indeed, all that is needed to read an FML file is the appropriate schema for that file, and an FML parser. This markup approach makes it much easier to exchange fuzzy systems between software: for example, a machine learning application could extract fuzzy rules which could then be read directly into a fuzzy inference engine or uploaded into a fuzzy controller. Also, with technologies like XSLT, it is possible to compile the FML into the programming language of your choice, ready for embedding into whatever application you please. As stated by Mike Watts on his popular Computational Intelligence blog: "Although Acampora's motivation for developing FML seems to be to develop embedded fuzzy controllers for ambient intelligence applications, FML could be a real boon for developers of fuzzy rule extraction algorithms: from my own experience during my PhD, I know that having to design a file format and implement the appropriate parsers for rule extraction and fuzzy inference engines can be a real pain, taking as much time as implementing the rule extraction algorithm itself. I would much rather have used something like FML for my work." A complete overview of FML and related applications can be found in the book titled On the power of Fuzzy Markup Language edited by Giovanni Acampora, Chang-Shing Lee, Vincenzo Loia and Mei-Hui Wang, and published by Springer in the series Studies on Fuzziness and Soft Computing. == Syntax, grammar and hardware synthesis == FML allows fuzzy systems to be coded through a collection of correlated semantic tags capable of modeling the different components of a classical fuzzy controller such as knowledge base, rule base, fuzzy variables and fuzzy rules. Therefore, the FML tags used to build a fuzzy controller represent the set of lexemes used to create fuzzy expressions. In order to design a well-formed XML-based language, an FML context-free grammar is defined by means of a XML schema which defines name, type and attributes characterized each XML element. However, since an FML program represents only a static view of a fuzzy logic controller, XSLT is provided to change this static view to a computable version. Indeed, XSLTs modules are able to convert the FML-based fuzzy controller in a general purpose computer language using an XSL file containing the translation description. At this level, the control is executable for the hardware. In short, FML is essentially composed by three layers: XML in order to create a new markup language for fuzzy logic control; a XML Schema in order to define the legal building blocks; eXtensible Stylesheet Language Transformations (XSLT) in order to convert a fuzzy controller description into a specific programming language. === Syntax === FML syntax is composed of XML tags and attributes which describe the different components of a fuzzy logic controller listed below: fuzzy knowledge base; fuzzy rule base; inference engine fuzzification subsystem; defuzzification subsystem. In detail, the opening tag of each FML program is which represents the fuzzy controller under modeling. This tag has two attributes: name and ip. The first attribute permits to specify the name of fuzzy controller and ip is used to define the location of controller in a computer network. The fuzzy knowledge base is defined by means of the tag which maintains the set of fuzzy concepts used to model the fuzzy rule base. In order to define the fuzzy concept related controlled system, tag uses a set of nested tags: defines the fuzzy concept; defines a linguistic term describing the fuzzy concept; a set of tags defining a shape of fuzzy sets are related to fuzzy terms. The attributes of tag are: name, scale, domainLeft, domainRight, type and, for only an output, accumulation, defuzzifier and defaultValue. The name attribute defines the name of fuzzy concept, for instance, temperature; scale is used to define the scale used to measure the fuzzy concept, for instance, Celsius degree; domainLeft and domainRight are used to model the universe of discourse of fuzzy concept, that is, the set of real values related to fuzzy concept, for instance [0°,40°] in the case of Celsius degree; the position of fuzzy concept into rule (consequent part or antecedent part) is defined by type attribute (input/output); accumulation attribute defines the method of accumulation that is a method that permits the combination of results of a variable of each rule in a final result; defuzzifier attribute defines the method used to execute the conversion from a fuzzy set, obtained after aggregation process, into a numerical value to give it in output to system; defaultValue attribute defines a real value used only when no rule has fired for the variable at issue. As for tag , it uses two attributes: name used to identify the linguistic value associate with fuzzy concept and complement, a boolean attribute that defines, if it is true, it is necessary to consider the complement of membership function defined by given parameters. Fuzzy shape tags, used to complete the definition of fuzzy concept, are: Every shaping tag uses a set of attributes which defines the real outline of corresponding fuzzy set. The number of these attributes depends on the chosen fuzzy set shape. In order to make an example, consider the Tipper Inference System described in Mathworks Matlab Fuzzy Logic Toolbox Tutorial. This Mamdani system is used to regulate the tipping in, for example, a restaurant. It has got two variables in input (food and service) and one in output (tip). FML code for modeling part of knowledge base of this fuzzy system containing variables food and tip is shown below. A special tag that can furthermore be used to define a fuzzy shape is . This tag is used to customize fuzzy shape (custom shape). The custom shape modeling is performed via a set of tags that lists the extreme points of geometric area defining the custom fuzzy shape. Obviously, the attributes used in tag are x and y coordinates. As for rule base component, FML allows to define a set of rule bases, each one of them describes a different behavior of system. The root of each rule base is modeled by tag which defines a fuzzy rule set. The tag uses five attributes: name, type, activationMethod, andMethod and orMethod. Obviously, the name attribute uniquely identifies the rule base. The type attribute permits to specify the kind of fuzzy controller (Mamdani or TSK) respect to the rule base at issue. The activationMethod attribute defines the method used to implication process; the andMethod and orMethod attribute define, respectively, the and and or algorithm to use by default. In order to define the single rule the tag is used. The attributes used by the tag are: name, connector, operator and weight. The name attribute permits to identify the rule; connector is used to define the logical operator used to connect the different clauses in antecedent part (and/or); operator defines the algorithm to use for chosen connector; weight defines the importance of rule during inference engine step. The definition of antecedent and consequent rule part is obtained by using and tags. tag is used to model the fuzzy clauses in antecedent and consequent part. This tag use the attribute modifier to describe a modification to term used in the clause. The possible values for this attribute are: above, below, extremely, intensify, more or less, norm, not, plus, slightly, somewhat, very, none. To complete the definition of fuzzy clause the nested and tags have to be used. A sequence of tags realizes a fuzzy rule base. As example, consider a Mamdani rule composed by (food is rancid) OR (servi

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  Big Mechanism

  Big Mechanism is a $45 million DARPA research program, begun in 2014, aimed at developing software that will read cancer research papers, integrate them into a cancer model and frame new hypotheses by the end of 2017 through the automated collection of big data and integrating across various disciplines such as knowledge-based NLP, curation and ontology, systems and mathematical biology by reading research abstracts and papers to extract pieces of causal mechanisms. == Ras gene == The program focuses on mutations in the Ras gene family, which underlie some one-third of human cancers. Currently, a rough road map shows interaction sequences among proteins affecting cell replication and death. However, the causal relations are poorly understood. == Plan == The program is to occur in three stages. The first is to read literature and convert it into formal representations. Second is to integrate the knowledge into computational models. Third is to produce experimentally testable explanations and predictions. Research teams are developing four separate systems targeting all three tasks. In February 2015, an evaluation meeting reviewed progress on the first stage. Multiple tasks were considered. One was extraction of experimental procedure details and evaluating statements such as "we demonstrate" and "we suggest." Another worked to map sentence meaning and relationships. The best machine-reading system extracted 40% of relevant information from a small corpus and correctly determined how each passage related to the model. The second stage is to become active in summer 2015, when members attempt to produce a single reference model. The third stage is the most challenging, because the artificial intelligence community has had limited success at developing hypothesis generators. Molecular biology may be more amenable, because most domain knowledge is technical and available in written form.

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