The Facebook Platform is the set of services, tools, and products provided by the social networking service Facebook for third-party developers to create their own applications and services that access data in Facebook. The current Facebook Platform was launched in 2010. The platform offers a set of programming interfaces and tools which enable developers to integrate with the open "social graph" of personal relations and other things like songs, places, and Facebook pages. Applications on facebook.com, external websites, and devices are all allowed to access the graph. == History == Facebook launched the Facebook Platform on May 24, 2007, providing a framework for software developers to create applications that interact with core Facebook features. A markup language called Facebook Markup Language was introduced simultaneously; it is used to customize the "look and feel" of applications that developers create. Prior to the Facebook platform, Facebook had built many applications themselves within the Facebook website, including Gifts, allowing users to send virtual gifts to each other, Marketplace, allowing users to post free classified ads, Facebook events, giving users a method of informing their friends about upcoming events, Video, letting users share homemade videos with one another, and social network game, where users can use their connections to friends to help them advance in games they are playing. The Facebook Platform made it possible for outside partners to build similar applications. Many of the popular early social network games would combine capabilities. For instance, one of the early games to reach the top application spot, (Lil) Green Patch, combined virtual Gifts with Event notifications to friends and contributions to charities through Causes. Third-party companies provide application metrics, and several blogs arose in response to the clamor for Facebook applications. On July 4, 2007, Altura Ventures announced the "Altura 1 Facebook Investment Fund," becoming the world's first Facebook-only venture capital firm. On August 29, 2007, Facebook changed the way in which the popularity of applications is measured, to give attention to the more engaging applications, following criticism that ranking applications only by the number of people who had installed the application was giving an advantage to the highly viral, yet useless applications. Tech blog Valleywag has criticized Facebook Applications, labeling them a "cornucopia of uselessness." Others have called for limiting third-party applications so the Facebook user experience is not degraded. Applications that have been created on the Platform include chess, which both allow users to play games with their friends. In such games, a user's moves are saved on the website, allowing the next move to be made at any time rather than immediately after the previous move. By November 3, 2007, seven thousand applications had been developed on the Facebook Platform, with another hundred created every day. By the second annual f8 developers conference on July 23, 2008, the number of applications had grown to 33,000, and the number of registered developers had exceeded 400,000. Within a few months of launching the Facebook Platform, issues arose regarding "application spam", which involves Facebook applications "spamming" users to request it be installed. Facebook integration was announced for the Xbox 360 and Nintendo DSi on June 1, 2009 at E3. On November 18, 2009, Sony announced an integration with Facebook to deliver the first phase of a variety of new features to further connect and enhance the online social experiences of PlayStation 3. On February 2, 2010, Facebook announced the release of HipHop for PHP as an opensource project. Mark Zuckerberg said that his team from Facebook is developing a Facebook search engine. “Facebook is pretty well placed to respond to people’s questions. At some point, we will. We have a team that is working on it", said Mark Zuckerberg. For him, the traditional search engines return too many results that do not necessarily respond to questions. “The search engines really need to evolve a set of answers: 'I have a specific question, answer this question for me.'" On June 10, 2014, Facebook announced Haxl, a Haskell library that simplified the access to remote data, such as databases or web-based services. === Partnerships with device manufacturers === Starting in 2007, Facebook formed data sharing partnerships with at least 60 handset manufacturers, including Apple, Amazon, BlackBerry, Microsoft and Samsung. Those manufacturers were provided with Facebook user data without the users' consent. Most of the partnerships remained in place as of 2018, when the partnerships were first publicly reported. == High-level Platform components == === Graph API === The Graph API is the core of Facebook Platform, enabling developers to read from and write data into Facebook. The Graph API presents a simple, consistent view of the Facebook social graph, uniformly representing objects in the graph (e.g., people, photos, events, and pages) and the connections between them (e.g., friend relationships, shared content, and photo tags). On April 30, 2015, Facebook shut down friends' data API prior to the v2.0 release. === Authentication === Facebook authentication enables developers’ applications to interact with the Graph API on behalf of Facebook users, and it provides a single-sign on mechanism across web, mobile, and desktop apps. ==== Facebook Connect ==== Facebook Connect, also called Log in with Facebook, like OpenID, is a set of authentication APIs from Facebook that developers can use to help their users connect and share with such users' Facebook friends (on and off Facebook) and increase engagement for their website or application. When so used, Facebook members can log on to third-party websites, applications, mobile devices and gaming systems with their Facebook identity and, while logged in, can connect with friends via these media and post information and updates to their Facebook profile. Originally unveiled during Facebook's developer conference, F8, in July 2008, Log in with Facebook became generally available in December 2008. According to an article from The New York Times, "Some say the services are representative of surprising new thinking in Silicon Valley. Instead of trying to hoard information about their users, the Internet companies (including Facebook, Google, MySpace and Twitter) all share at least some of that data so people do not have to enter the same identifying information again and again on different sites." Log in with Facebook cannot be used by users in locations that cannot access Facebook, even if the third-party site is otherwise accessible from that location. According to Facebook, users who logged into The Huffington Post with Facebook spent more time on the site than the average user. === Social plugins === Social plugins – including the Like Button, Recommendations, and Activity Feed – enable developers to provide social experiences to their users with just a few lines of HTML. All social plugins are extensions of Facebook and are designed so that no user data is shared with the sites on which they appear. On the other hand, the social plugins let Facebook track its users’ browsing habits through any sites that feature the plugins. === Open Graph protocol === The Open Graph protocol enables developers to integrate their pages into Facebook's global mapping/tracking tool Social Graph. These pages gain the functionality of other graph objects including profile links and stream updates for connected users. OpenGraph tags in HTML5 might look like this: === iframes === Facebook uses iframes to allow third-party developers to create applications that are hosted separately from Facebook, but operate within a Facebook session and are accessed through a user's profile. Since iframes essentially nest independent websites within a Facebook session, their content is distinct from Facebook formatting. Facebook originally used 'Facebook Markup Language (FBML)' to allow Facebook Application developers to customize the "look and feel" of their applications, to a limited extent. FBML is a specification of how to encode content so that Facebook's servers can read and publish it, which is needed in the Facebook-specific feed so that Facebook's system can properly parse content and publish it as specified. FBML set by any application is cached by Facebook until a subsequent API call replaces it. Facebook also offers a specialized Facebook JavaScript (FBJS) library. Facebook stopped accepting new FBML applications on March 18, 2011, but continued to support existing FBML tabs and applications. Since January 1, 2012 FBML was no longer supported, and FBML no longer functioned as of June 1, 2012. === Microformats === In February 2011, Facebook began to use the hCalendar microformat to mark up events, and the hCard for the events' venues,
Super-resolution optical fluctuation imaging
Super-resolution optical fluctuation imaging (SOFI) is a post-processing method for the calculation of super-resolved images from recorded image time series that is based on the temporal correlations of independently fluctuating fluorescent emitters. SOFI has been developed for super-resolution of biological specimen that are labelled with independently fluctuating fluorescent emitters (organic dyes, fluorescent proteins). In comparison to other super-resolution microscopy techniques such as STORM or PALM that rely on single-molecule localization and hence only allow one active molecule per diffraction-limited area (DLA) and timepoint, SOFI does not necessitate a controlled photoswitching and/ or photoactivation as well as long imaging times. Nevertheless, it still requires fluorophores that are cycling through two distinguishable states, either real on-/off-states or states with different fluorescence intensities. In mathematical terms SOFI-imaging relies on the calculation of cumulants, for what two distinguishable ways exist. For one thing an image can be calculated via auto-cumulants that by definition only rely on the information of each pixel itself, and for another thing an improved method utilizes the information of different pixels via the calculation of cross-cumulants. Both methods can increase the final image resolution significantly although the cumulant calculation has its limitations. Actually SOFI is able to increase the resolution in all three dimensions. == Principle == Likewise to other super-resolution methods SOFI is based on recording an image time series on a CCD- or CMOS camera. In contrary to other methods the recorded time series can be substantially shorter, since a precise localization of emitters is not required and therefore a larger quantity of activated fluorophores per diffraction-limited area is allowed. The pixel values of a SOFI-image of the n-th order are calculated from the values of the pixel time series in the form of a n-th order cumulant, whereas the final value assigned to a pixel can be imagined as the integral over a correlation function. The finally assigned pixel value intensities are a measure of the brightness and correlation of the fluorescence signal. Mathematically, the n-th order cumulant is related to the n-th order correlation function, but exhibits some advantages concerning the resulting resolution of the image. Since in SOFI several emitters per DLA are allowed, the photon count at each pixel results from the superposition of the signals of all activated nearby emitters. The cumulant calculation now filters the signal and leaves only highly correlated fluctuations. This provides a contrast enhancement and therefore a background reduction for good measure. As it is implied in the figure on the left the fluorescence source distribution: ∑ k = 1 N δ ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) {\displaystyle \sum _{k=1}^{N}\delta ({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t)} is convolved with the system's point spread function (PSF) U(r). Hence the fluorescence signal at time t and position r → {\displaystyle {\vec {r}}} is given by F ( r → , t ) = ∑ k = 1 N U ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) . {\displaystyle F({\vec {r}},t)=\sum _{k=1}^{N}U({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t).} Within the above equations N is the amount of emitters, located at the positions r → k {\displaystyle {\vec {r}}_{k}} with a time-dependent molecular brightness ε k ⋅ s k {\displaystyle \varepsilon _{k}\cdot s_{k}} where ε k {\displaystyle \varepsilon _{k}} is a variable for the constant molecular brightness and s k ( t ) {\displaystyle s_{k}(t)} is a time-dependent fluctuation function. The molecular brightness is just the average fluorescence count-rate divided by the number of molecules within a specific region. For simplification it has to be assumed that the sample is in a stationary equilibrium and therefore the fluorescence signal can be expressed as a zero-mean fluctuation: δ F ( r → , t ) = F ( r → , t ) − ⟨ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=F({\vec {r}},t)-\langle F({\vec {r}},t)\rangle _{t}} where ⟨ ⋯ ⟩ t {\displaystyle \langle \cdots \rangle _{t}} denotes time-averaging. The auto-correlation here e.g. the second-order can then be described deductively as follows for a certain time-lag τ {\displaystyle \tau } : δ F ( r → , t ) = ⟨ δ F ( r → , t + τ ) ⋅ δ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=\langle \delta F({\vec {r}},t+\tau )\cdot \delta F({\vec {r}},t)\rangle _{t}} From these equations it follows that the PSF of the optical system has to be taken to the power of the order of the correlation. Thus in a second-order correlation the PSF would be reduced along all dimensions by a factor of 2 {\displaystyle {\sqrt {2}}} . As a result, the resolution of the SOFI-images increases according to this factor. === Cumulants versus correlations === Using only the simple correlation function for a reassignment of pixel values, would ascribe to the independency of fluctuations of the emitters in time in a way that no cross-correlation terms would contribute to the new pixel value. Calculations of higher-order correlation functions would suffer from lower-order correlations for what reason it is superior to calculate cumulants, since all lower-order correlation terms vanish. == Cumulant-calculation == === Auto-cumulants === For computational reasons it is convenient to set all time-lags in higher-order cumulants to zero so that a general expression for the n-th order auto-cumulant can be found: A C n ( r → , τ 1 … n − 1 = 0 ) = ∑ k = 1 N U n ( r → − r → k ) ε k n w k ( 0 ) {\displaystyle AC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\sum _{k=1}^{N}U^{n}({\vec {r}}-{\vec {r}}_{k})\varepsilon _{k}^{n}w_{k}(0)} w k {\displaystyle w_{k}} is a specific correlation based weighting function influenced by the order of the cumulant and mainly depending on the fluctuation properties of the emitters. Albeit there is no fundamental limitation in calculating very high orders of cumulants and thereby shrinking the FWHM of the PSF there are practical limitations according to the weighting of the values assigned to the final image. Emitters with a higher molecular brightness will show a strong increase in terms of the pixel cumulant value assigned at higher-orders as well as this performance can be expected from a diverse appearance of fluctuations of different emitters. A wide intensity range of the resulting image can therefore be expected and as a result dim emitters can get masked by bright emitters in higher-order images:. The calculation of auto-cumulants can be realized in a very attractive way in a mathematical sense. The n-th order cumulant can be calculated with a basic recursion from moments K n ( r → ) = μ n ( r → ) − ∑ i = 1 n − 1 ( n − 1 i ) K n − i ( r → ) μ i ( r → ) {\displaystyle K_{n}({\vec {r}})=\mu _{n}({\vec {r}})-\sum _{i=1}^{n-1}{\begin{pmatrix}n-1\\i\end{pmatrix}}K_{n-i}({\vec {r}})\mu _{i}({\vec {r}})} where K is a cumulant of the index's order, likewise μ {\displaystyle \mu } represents the moments. The term within the brackets indicates a binomial coefficient. This way of computation is straightforward in comparison with calculating cumulants with standard formulas. It allows for the calculation of cumulants with only little time of computing and is, as it is well implemented, even suitable for the calculation of high-order cumulants on large images. === Cross-cumulants === In a more advanced approach cross-cumulants are calculated by taking the information of several pixels into account. Cross-cumulants can be described as follows: C C n ( r → , τ 1 … n − 1 = 0 ) = ∏ j < l n U ( r → j − r → l n ) ⋅ ∑ i = 1 N U n ( r → i − ∑ k n r → k n ) ε i n w i ( 0 ) {\displaystyle CC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\prod _{j DALL-E, DALL-E 2, and DALL-E 3 (stylised DALL·E) are text-to-image models developed by OpenAI using deep learning methodologies to generate digital images from natural language descriptions known as prompts. The first version of DALL-E was announced in January 2021. In the following year, its successor DALL-E 2 was released. DALL-E 3 was released natively into ChatGPT for ChatGPT Plus and ChatGPT Enterprise customers in October 2023, with availability via OpenAI's API and "Labs" platform provided in early November. Microsoft implemented the model in Bing's Image Creator tool and plans to implement it into their Designer app. With Bing's Image Creator tool, Microsoft Copilot runs on DALL-E 3. In March 2025, DALL-E-3 was replaced in ChatGPT by GPT Image's native image-generation capabilities. == History and background == DALL-E was revealed by OpenAI in a blog post on 5 January 2021, and uses a version of GPT-3 modified to generate images. On 6 April 2022, OpenAI announced DALL-E 2, a successor designed to generate more realistic images at higher resolutions that "can combine concepts, attributes, and styles". On 20 July 2022, DALL-E 2 entered into a beta phase with invitations sent to 1 million waitlisted individuals; users could generate a certain number of images for free every month and may purchase more. Access had previously been restricted to pre-selected users for a research preview due to concerns about ethics and safety. On 28 September 2022, DALL-E 2 was opened to everyone and the waitlist requirement was removed. In September 2023, OpenAI announced their latest image model, DALL-E 3, capable of understanding "significantly more nuance and detail" than previous iterations. In early November 2022, OpenAI released DALL-E 2 as an API, allowing developers to integrate the model into their own applications. Microsoft unveiled their implementation of DALL-E 2 in their Designer app and Image Creator tool included in Bing and Microsoft Edge. The API operates on a cost-per-image basis, with prices varying depending on image resolution. Volume discounts are available to companies working with OpenAI's enterprise team. The software's name is a portmanteau of the names of animated robot Pixar character WALL-E and the Spanish surrealist artist Salvador Dalí. In February 2024, OpenAI began adding watermarks to DALL-E generated images, containing metadata in the C2PA (Coalition for Content Provenance and Authenticity) standard promoted by the Content Authenticity Initiative. == Technology == The first generative pre-trained transformer (GPT) model was initially developed by OpenAI in 2018, using a Transformer architecture. The first iteration, GPT-1, was scaled up to produce GPT-2 in 2019; in 2020, it was scaled up again to produce GPT-3, with 175 billion parameters. === DALL-E === DALL-E has three components: a discrete VAE, an autoregressive decoder-only Transformer model (12 billion parameters) similar to GPT-3, and a CLIP pair of image encoder and text encoder. The discrete VAE can convert an image to a sequence of tokens, and conversely, convert a sequence of tokens back to an image. This is necessary as the Transformer model does not directly process image data. The input to the Transformer model is a sequence of tokenised image caption followed by tokenised image patches. The image caption is in English, tokenised by byte pair encoding (vocabulary size 16384), and can be up to 256 tokens long. Each image is a 256×256 RGB image, divided into 32×32 patches of 4×4 each. Each patch is then converted by a discrete variational autoencoder to a token (vocabulary size 8192). DALL-E was developed and announced to the public in conjunction with CLIP (Contrastive Language-Image Pre-training). CLIP is a separate model based on contrastive learning that was trained on 400 million pairs of images with text captions scraped from the Internet. Its role is to "understand and rank" DALL-E's output by predicting which caption from a list of 32,768 captions randomly selected from the dataset (of which one was the correct answer) is most appropriate for an image. A trained CLIP pair is used to filter a larger initial list of images generated by DALL-E to select the image that is closest to the text prompt. === DALL-E 2 === DALL-E 2 uses 3.5 billion parameters, a smaller number than its predecessor. Instead of an autoregressive Transformer, DALL-E 2 uses a diffusion model conditioned on CLIP image embeddings, which, during inference, are generated from CLIP text embeddings by a prior model. This is the same architecture as that of Stable Diffusion, released a few months later. === DALL-E 3 === While a technical report was written for DALL-E 3, it does not include training or implementation details of the model, instead focusing on the improved prompt following capabilities developed for DALL-E 3. == Capabilities == DALL-E can generate imagery in multiple styles, including photorealistic imagery, paintings, and emoji. It can "manipulate and rearrange" objects in its images, and can correctly place design elements in novel compositions without explicit instruction. Thom Dunn writing for BoingBoing remarked that "For example, when asked to draw a daikon radish blowing its nose, sipping a latte, or riding a unicycle, DALL-E often draws the handkerchief, hands, and feet in plausible locations." DALL-E showed the ability to "fill in the blanks" to infer appropriate details without specific prompts, such as adding Christmas imagery to prompts commonly associated with the celebration, and appropriately placed shadows to images that did not mention them. Furthermore, DALL-E exhibits a broad understanding of visual and design trends. DALL-E can produce images for a wide variety of arbitrary descriptions from various viewpoints with only rare failures. Mark Riedl, an associate professor at the Georgia Tech School of Interactive Computing, found that DALL-E could blend concepts (described as a key element of human creativity). Its visual reasoning ability is sufficient to solve Raven's Matrices (visual tests often administered to humans to measure intelligence). DALL-E 3 follows complex prompts with more accuracy and detail than its predecessors, and is able to generate more coherent and accurate text. DALL-E 3 is integrated into ChatGPT Plus. === Image modification === Given an existing image, DALL-E 2 and DALL-E 3 can produce "variations" of the image as individual outputs based on the original, as well as edit the image to modify or expand upon it. The "inpainting" and "outpainting" abilities of these models use context from an image to fill in missing areas using a medium consistent with the original, following a given prompt. For example, this can be used to insert a new subject into an image, or expand an image beyond its original borders. According to OpenAI, "Outpainting takes into account the image’s existing visual elements — including shadows, reflections, and textures — to maintain the context of the original image." === Technical limitations === DALL-E 2's language understanding has limits. It is sometimes unable to distinguish "A yellow book and a red vase" from "A red book and a yellow vase" or "A panda making latte art" from "Latte art of a panda". It generates images of an astronaut riding a horse when presented with the prompt "a horse riding an astronaut". It also fails to generate the correct images in a variety of circumstances. Requesting more than three objects, negation, numbers, and connected sentences may result in mistakes, and object features may appear on the wrong object. Additional limitations include generating text, ambigrams and other forms of typography, which often results in dream-like gibberish. The model also has a limited capacity to address scientific information, such as astronomy or medical imagery. == Ethical concerns == DALL-E 2's reliance on public datasets influences its results and leads to algorithmic bias in some cases, such as generating higher numbers of men than women for requests that do not mention gender. DALL-E 2's training data was filtered to remove violent and sexual imagery, but this was found to increase bias in some cases such as reducing the frequency of women being generated. OpenAI hypothesise that this may be because women were more likely to be sexualised in training data which caused the filter to influence results. In September 2022, OpenAI confirmed to The Verge that DALL-E invisibly inserts phrases into user prompts to address bias in results; for instance, "black man" and "Asian woman" are inserted into prompts that do not specify gender or race. OpenAI claims to address concerns for potential "racy content" – containing nudity or sexual content generation, with DALL-E 3 through input/output filters, blocklists, ChatGPT refusals, and model level interventions. However, DALL-E 3 continues to disproportionally represent people as White, female, and youthful. Users are able to somewhat remedy Frank Hutter is a German computer scientist recognized for his contributions to machine learning, particularly in the areas of automated machine learning (AutoML), hyperparameter optimization, meta-learning and tabular machine learning. He is currently a Hector-Endowed Fellow and PI at the ELLIS Institute Tübingen and a Full Professor (W3) for Machine Learning at the Department of Computer Science, University of Freiburg. Hutter is known for his role in establishing AutoML as a key area in artificial intelligence research. == Education and academic career == Frank Hutter received his academic training in computer science at Darmstadt University of Technology, where he completed his Vordiplom (comparable to a BSc) and Hauptdiplom (equivalent to MSc) by 2004. He later pursued his PhD at the University of British Columbia, under the supervision of Profs. Holger Hoos, Kevin Leyton-Brown and Kevin Murphy, where his doctoral thesis, titled "Automated Configuration of Algorithms for Solving Hard Computational Problems," was awarded the CAIAC Doctoral Dissertation Award for the best thesis in Artificial Intelligence completed at a Canadian university in 2009. Hutter did his postdoctoral research at the University of British Columbia, where he worked from 2009 to 2013. In 2013, he moved to the University of Freiburg, initially leading an Emmy Noether Research Group, and in 2017, he was appointed as a Full Professor. His contributions to machine learning have been recognized globally, particularly his work in AutoML and hyperparameter optimization. Overall, Hutter has authored over 180 peer-reviewed publications, which have garnered more than 89,000 citations, reflecting the high impact of his work. == Contributions in AutoML == Hutter's early research laid the groundwork for the field of Automated Machine Learning (AutoML). He has been a key figure in establishing AutoML as a distinct research area. Along with various colleagues, he organized the AutoML workshops from 2014 to 2021, wrote the first book on AutoML and taught the first MOOC on AutoML. He also co-founded the AutoML conference in 2022 and served as its general chair the first two years. He also published prominent works in various subfields of AutoML, such as hyperparameter optimization, neural architecture search, meta-Learning and AutoML systems. He is currently the most highly cited researcher in AutoML. == Contributions in machine learning for tabular data == Hutter has also made many contributions to machine learning for tabular data. He led the development of the first widely adopted AutoML system for tabular data, AutoWEKA, which was published at KDD 2013 and received the test of time award at KDD (2023). Subsequently, he led the development of Auto-sklearn, the first highly used AutoML system for tabular data in Python, and with it, won the first international AutoML challenge and the subsequent second international AutoML challenge, both of which only included tabular data. More recently, he focused on tabular foundation models, including TabPFN, which was published in Nature magazine. In 2024, he also co-founded Prior Labs, the first company focusing on tabular foundation models. == Awards and honors == Hutter has received numerous awards throughout his career. In 2023, he won the KDD Test of Time Award for Research together with Chris Thornton, Holger H. Hoos, and Kevin Leyton-Brown. He has received three grants from the ERC, including the ERC Starting Grant (2016) and ERC Consolidator Grant (2022), as well as an ERC Proof of Concept Grant (2020). In 2021, he became an ELLIS Unit Director and was also recognized as a EurAI Fellow, in addition to receiving the AIJ Prominent Paper Award. Earlier, he was a recipient of the Google Faculty Research Award in 2018. His groundbreaking research was acknowledged early in his career with the IJCAI Distinguished Paper Award in 2013 and the IJCAI/JAIR Best Paper Prize in 2010. == Representative publications == Hutter, F. Kotthoff, L. and Vanschoren, J., editors. Automated machine learning: methods, systems, challenges, Springer Nature, 2019. www.automl.org/book. Feurer, M., Klein, A., Eggensperger, K., Springenberg, T., Blum, M., Hutter, F. Efficient and Robust Automated Machine Learning. In NeurIPS 2015. Loshchilov, I., and Hutter, F. Decoupled weight decay regularization. In ICLR 2018. Zela, A., Elsken, T. ,Saikia, T. ,Marrakschi, Y. ,Brox, T. and Hutter. ,F.Understanding and Robustifying Differentiable Architecture Search. In ICLR 2020. Hollmann, N., Müller, S., Eggensperger, K. and Hutter, F. TabPFN: A Transformer That Solves Small Tabular Classification Problems in a Second, In ICLR 2023. In search of the best AI headshot generator? An AI headshot generator is software that uses machine learning to help you get more done — it turns a rough idea into a polished result in seconds. When choosing one, weigh output quality, pricing, export formats, and how well it fits the tools you already use. Whether you are a beginner or a pro, the right AI headshot generator slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence. A GeneRIF or Gene Reference Into Function is a short (255 characters or fewer) statement about the function of a gene. GeneRIFs provide a simple mechanism for allowing scientists to add to the functional annotation of genes described in the Entrez Gene database. In practice, function is constructed quite broadly. For example, there are GeneRIFs that discuss the role of a gene in a disease, GeneRIFs that point the viewer towards a review article about the gene, and GeneRIFs that discuss the structure of a gene. However, the stated intent is for GeneRIFs to be about gene function. Currently over half a million geneRIFs have been created for genes from almost 1000 different species. GeneRIFs are always associated with specific entries in the Entrez Gene database. Each GeneRIF has a pointer to the PubMed ID (a type of document identifier) of a scientific publication that provides evidence for the statement made by the GeneRIF. GeneRIFs are often extracted directly from the document that is identified by the PubMed ID, very frequently from its title or from its final sentence. GeneRIFs are usually produced by NCBI indexers, but anyone may submit a GeneRIF. To be processed, a valid Gene ID must exist for the specific gene, or the Gene staff must have assigned an overall Gene ID to the species. The latter case is implemented via records in Gene with the symbol NEWENTRY. Once the Gene ID is identified, only three types of information are required to complete a submission: a concise phrase describing a function or functions (less than 255 characters in length, preferably more than a restatement of the title of the paper); a published paper describing that function, implemented by supplying the PubMed ID of a citation in PubMed; a valid e-mail address (which will remain confidential). == Example == Here are some GeneRIFs taken from Entrez Gene for GeneID 7157, the human gene TP53. The PubMed document identifiers have been omitted from the examples. Note the wide variability with respect to the presence or absence of punctuation and of sentence-initial capital letters. p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer Degradation of endogenous HIPK2 depends on the presence of a functional p53 protein. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 Logistic regression analysis showed p53 and COX-2 as dependent predictors in pancreatic carcinogenesis, and a reciprocal relationship to neoplastic progression between p53 and COX-2. GeneRIFs are an unusual type of textual genre, and they have recently been the subject of a number of articles from the natural language processing community. Paul Christiano is an American researcher in the field of artificial intelligence (AI), with a specific focus on AI alignment, which is the subfield of AI safety research that aims to steer AI systems toward human interests. He serves as the Head of Safety for the Center for AI Standards and Innovation inside NIST. He formerly led the language model alignment team at OpenAI and became founder and head of the non-profit Alignment Research Center (ARC), which works on theoretical AI alignment and evaluations of machine learning models. In 2023, Christiano was named as one of the TIME 100 Most Influential People in AI (TIME100 AI). In September 2023, Christiano was appointed to the UK government's Frontier AI Taskforce advisory board. Before working at the Center for AI Standards and Innovation, he was an initial trustee on Anthropic's Long-Term Benefit Trust. == Education == Christiano attended the Harker School in San Jose, California. He competed on the U.S. team and won a silver medal at the 49th International Mathematics Olympiad (IMO) in 2008. In 2012, Christiano graduated from the Massachusetts Institute of Technology (MIT) with a degree in mathematics. At MIT, he researched data structures, quantum cryptography, and combinatorial optimization. He then went on to complete a PhD at the University of California, Berkeley. While at Berkeley, Christiano collaborated with researcher Katja Grace on AI Impacts, co-developing a preliminary methodology for comparing supercomputers to brains, using traversed edges per second (TEPS). He also experimented with putting Carl Shulman's donor lottery theory into practice, raising nearly $50,000 in a pool to be donated to a single charity. == Career == At OpenAI, Christiano co-authored the paper "Deep Reinforcement Learning from Human Preferences" (2017) and other works developing reinforcement learning from human feedback (RLHF). He is considered one of the principal architects of RLHF, which in 2017 was "considered a notable step forward in AI safety research", according to The New York Times. Other works such as "AI safety via debate" (2018) focus on the problem of scalable oversight – supervising AIs in domains where humans would have difficulty judging output quality. Christiano left OpenAI in 2021 to work on more conceptual and theoretical issues in AI alignment and subsequently founded the Alignment Research Center to focus on this area. One subject of study is the problem of eliciting latent knowledge from advanced machine learning models. ARC also develops techniques to identify and test whether an AI model is potentially dangerous. In April 2023, Christiano told The Economist that ARC was considering developing an industry standard for AI safety. As of April 2024, Christiano was listed as the head of AI safety for the US AI Safety Institute at NIST. One month earlier in March 2024, staff members and scientists at the institute threatened to resign upon being informed of Christiano's pending appointment to the role, stating that his ties to the effective altruism movement may jeopardize the AI Safety Institute's objectivity and integrity. === Views on AI risks === He is known for his views on the potential risks of advanced AI. In 2017, Wired magazine stated that Christiano and his colleagues at OpenAI weren't worried about the destruction of the human race by "evil robots", explaining that "[t]hey’re more concerned that, as AI progresses beyond human comprehension, the technology’s behavior may diverge from our intended goals." However, in a widely quoted interview with Business Insider in 2023, Christiano said that there is a “10–20% chance of AI takeover, [with] many [or] most humans dead.” He also conjectured a “50/50 chance of doom shortly after you have AI systems that are human level.” == Personal life == Christiano is married to Ajeya Cotra, a member of METR's technical staff.DALL-E
Frank Hutter
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Paul Christiano