In the United States, prescription monitoring programs (PMPs) or prescription drug monitoring programs (PDMPs) are state-run programs which collect and distribute data about the prescription and dispensation of federally controlled substances and, depending on state requirements, other potentially abusable prescription drugs. PMPs are meant to help prevent adverse drug-related events such as opioid overdoses, drug diversion, and substance abuse by decreasing the amount and/or frequency of opioid prescribing, and by identifying those patients who are obtaining prescriptions from multiple providers (i.e., "doctor shopping") or those physicians overprescribing opioids. Most US health care workers support the idea of PMPs, which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments. The database, whose use is required by State law, typically requires prescribers and pharmacies dispensing controlled substances to register with their respective state PMPs and (for pharmacies and providers who dispense from their offices) to report the dispensation of such prescriptions to an electronic online database. The majority of PMPs are authorized to notify law enforcement agencies or licensing boards or physicians when a prescriber, or patients receiving prescriptions, exceed thresholds established by the state or prescription recipient exceeds thresholds established by the State. All states have implemented PDMPs, although evidence for the effectiveness of these programs is mixed. While prescription of opioids has decreased with PMP use, overdose deaths in many states have actually increased, with those states sharing data with neighboring jurisdictions or requiring reporting of more drugs experiencing highest increases in deaths. This may be because those declined opioid prescriptions turn to street drugs, whose potency and contaminants carry greater overdose risk. == History == Prescription drug monitoring programs, or PDMPs, are an example of one initiative proposed to alleviate effects of the opioid crisis. The programs are designed to restrict prescription drug abuse by limiting a patient's ability to obtain similar prescriptions from multiple providers (i.e. “doctor shopping”) and reducing diversion of controlled substances. This is meant to reduce risk of fatal overdose caused by high doses of opioids or interactions between opioids and benzodiazepenes, and to enable better decision making on the part of healthcare providers who may be unaware of a patient's prescription drug use, history or other prescriptions. PDMPs have been implemented in state legislations since 1939 in California, a time before electronic medical records, though implementation rose alongside increased awareness of overprescribing of opioids and overdose. A later New York state program was struck down by the U.S. Supreme Court in Whalen v. Roe. But, by 2019, 49 states, the District of Columbia, and Guam had enacted PDMP legislation. In 2021 Missouri, the last State to not use a PMP, adopted legislation to create one. PMPs are constantly being updated to increase speed of data collection, sharing of data across States, and ease of interpretation. This is being done by integrating PDMP reports with other health information technologies such as health information exchanges (HIE), electronic health record (EHR) systems, and/ or pharmacy dispensing software systems. One program that has been implemented in nine states is called the PDMP Electronic Health Records Integration and Interoperability Expansion, also known as PEHRIIE. Another software, marketed by Bamboo Health and integrated with PMPs in 43 states, uses an algorithm to track factors thought to increase risk of diversion, abuse or overdose, and assigns patients a three digit score based on presumed indicators of risk. While some studies have suggested that PDMP-HIT integration and sharing of interstate data brings benefits such as reduced opioid-related inpatient morbidity, others have found no or negative impact on mortality compared to states without PMP data sharing. Patient and media reports suggest need for testing and evaluation of algorithmic software used to score risk, with some patients reporting denial of prescriptions without c explanation or clarity of data. == Goals == Most health care workers support PMPs which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments, as well as law-enforcement agencies. The collaboration supports the legitimate medical use of controlled substances while limiting their abuse and diversion. Pharmacies dispensing controlled substances and prescribers typically must register with their respective state PMPs and (for pharmacies and providers who dispense controlled substances from their offices) report the dispensation to an electronic online database. Some pharmacy software can submit these reports automatically to multiple states. == Usage == === List of programs by state === === Software systems === NarxCare is a prescription drug monitoring program (PDMP) run by Bamboo Health. Bamboo Health was formerly known as Appriss. It is widely used across the United States by pharmacies including Rite Aid as well as those at Walmart and Sam’s Club. The NarxCare software allows doctors to view data about a patient, combining data from the prescription registries of various U.S. states to make the registries interoperable nationally. It also uses machine learning to generate an "Overdose Risk Score" that potentially includes EMS and criminal justice data; these scores have been criticized by researchers and patient advocates for the lack of transparency in the process as well as the potential for disparate treatment of women and minority groups. Advertised as an "analytics tool and care management platform", the NarxCare software allows doctors to view data about a patient including how many pharmacies they have visited and the combinations of medication they are prescribed. It combines data from the prescription registries of various U.S. states, making the registries interoperable nationally. It additionally uses machine learning to generate various three-digit "risk scores" and an overall "Overdose Risk Score", collectively referred to as Narx Scores, in a process that potentially includes EMS and criminal justice data as well as court records. == Controversy == Many doctors and researchers support the idea of PDMPs as a tool in combatting the opioid epidemic. Opioid prescribing, opioid diversion and supply, opioid misuse, and opioid-related morbidity and mortality are common elements in data entered into PDMPs. Prescription Monitoring Programs are purported to offer economic benefits for the states who implement them by decreasing overall health care costs, lost productivity, and investigation times. However, there are many studies that conclude the impact of PDMPs is unclear. While use of PMPs has been accompanied by decrease in opioid prescribing, few analyses consider corresponding use of street opioids, extramedical use, or diversion, which might provide a more holistic method for evaluation of PMP intent and efficacy. Evidence for PDMP impact on fatal overdoses is decidedly mixed, with multiple studies finding increased overdose rates in some states, decreases in others, or no clear impact. Interestingly, an increase in heroin overdoses after PDMP implementation has been commonly reported, presumably as denial of prescription opioids sends patients in search of street drugs. Narx Scores have been criticized by researchers and patient advocates for the lack of transparency in the generation process as well as the potential for disparate treatment of women and minority groups. Writing in Duke Law Journal, Jennifer Oliva stated that "black-box algorithms" are used to generate the scores.
JAX (software)
JAX is a Python library for accelerator-oriented array computation and program transformation, designed for high-performance numerical computing and large-scale machine learning. It is developed by Google with contributions from Nvidia and other community contributors. It is described as bringing together a modified version of the automatic differentiation system autograd and OpenXLA's XLA (Accelerated Linear Algebra). It is designed to follow the structure and workflow of NumPy as closely as possible and works with various existing frameworks such as TensorFlow and PyTorch. The primary features of JAX are: Providing a unified NumPy-like interface to computations that run on CPU, GPU, or TPU, in local or distributed settings. Built-in Just-In-Time (JIT) compilation via OpenXLA, an open-source machine learning compiler ecosystem. Efficient evaluation of gradients via its automatic differentiation transformations. Automatic vectorization to efficiently map functions over arrays representing batches of inputs. == Libraries using Jax == Flax Equinox Optax
Probabilistic context-free grammar
In theoretical linguistics and computational linguistics, probabilistic context free grammars (PCFGs) extend context-free grammars, similar to how hidden Markov models extend regular grammars. Each production is assigned a probability. The probability of a derivation (parse) is the product of the probabilities of the productions used in that derivation. These probabilities can be viewed as parameters of the model, and for large problems it is convenient to learn these parameters via machine learning. A probabilistic grammar's validity is constrained by context of its training dataset. PCFGs originated from grammar theory, and have application in areas as diverse as natural language processing to the study the structure of RNA molecules and design of programming languages. Designing efficient PCFGs has to weigh factors of scalability and generality. Issues such as grammar ambiguity must be resolved. The grammar design affects results accuracy. Grammar parsing algorithms have various time and memory requirements. == Definitions == Derivation: The process of recursive generation of strings from a grammar. Parsing: Finding a valid derivation using an automaton. Parse Tree: The alignment of the grammar to a sequence. An example of a parser for PCFG grammars is the pushdown automaton. The algorithm parses grammar nonterminals from left to right in a stack-like manner. This brute-force approach is not very efficient. In RNA secondary structure prediction variants of the Cocke–Younger–Kasami (CYK) algorithm provide more efficient alternatives to grammar parsing than pushdown automata. Another example of a PCFG parser is the Stanford Statistical Parser which has been trained using Treebank. == Formal definition == Similar to a CFG, a probabilistic context-free grammar G can be defined by a quintuple: G = ( M , T , R , S , P ) {\displaystyle G=(M,T,R,S,P)} where M is the set of non-terminal symbols T is the set of terminal symbols R is the set of production rules S is the start symbol P is the set of probabilities on production rules == Relation with hidden Markov models == PCFGs models extend context-free grammars the same way as hidden Markov models extend regular grammars. The Inside-Outside algorithm is an analogue of the Forward-Backward algorithm. It computes the total probability of all derivations that are consistent with a given sequence, based on some PCFG. This is equivalent to the probability of the PCFG generating the sequence, and is intuitively a measure of how consistent the sequence is with the given grammar. The Inside-Outside algorithm is used in model parametrization to estimate prior frequencies observed from training sequences in the case of RNAs. Dynamic programming variants of the CYK algorithm find the Viterbi parse of a RNA sequence for a PCFG model. This parse is the most likely derivation of the sequence by the given PCFG. == Grammar construction == Context-free grammars are represented as a set of rules inspired from attempts to model natural languages. The rules are absolute and have a typical syntax representation known as Backus–Naur form. The production rules consist of terminal { a , b } {\displaystyle \left\{a,b\right\}} and non-terminal S symbols and a blank ϵ {\displaystyle \epsilon } may also be used as an end point. In the production rules of CFG and PCFG the left side has only one nonterminal whereas the right side can be any string of terminal or nonterminals. In PCFG nulls are excluded. An example of a grammar: S → a S , S → b S , S → ϵ {\displaystyle S\to aS,S\to bS,S\to \epsilon } This grammar can be shortened using the '|' ('or') character into: S → a S | b S | ϵ {\displaystyle S\to aS|bS|\epsilon } Terminals in a grammar are words and through the grammar rules a non-terminal symbol is transformed into a string of either terminals and/or non-terminals. The above grammar is read as "beginning from a non-terminal S the emission can generate either a or b or ϵ {\displaystyle \epsilon } ". Its derivation is: S ⇒ a S ⇒ a b S ⇒ a b b S ⇒ a b b {\displaystyle S\Rightarrow aS\Rightarrow abS\Rightarrow abbS\Rightarrow abb} Ambiguous grammar may result in ambiguous parsing if applied on homographs since the same word sequence can have more than one interpretation. Pun sentences such as the newspaper headline "Iraqi Head Seeks Arms" are an example of ambiguous parses. One strategy of dealing with ambiguous parses (originating with grammarians as early as Pāṇini) is to add yet more rules, or prioritize them so that one rule takes precedence over others. This, however, has the drawback of proliferating the rules, often to the point where they become difficult to manage. Another difficulty is overgeneration, where unlicensed structures are also generated. Probabilistic grammars circumvent these problems by ranking various productions on frequency weights, resulting in a "most likely" (winner-take-all) interpretation. As usage patterns are altered in diachronic shifts, these probabilistic rules can be re-learned, thus updating the grammar. Assigning probability to production rules makes a PCFG. These probabilities are informed by observing distributions on a training set of similar composition to the language to be modeled. On most samples of broad language, probabilistic grammars where probabilities are estimated from data typically outperform hand-crafted grammars. CFGs when contrasted with PCFGs are not applicable to RNA structure prediction because while they incorporate sequence-structure relationship they lack the scoring metrics that reveal a sequence structural potential == Weighted context-free grammar == A weighted context-free grammar (WCFG) is a more general category of context-free grammar, where each production has a numeric weight associated with it. The weight of a specific parse tree in a WCFG is the product (or sum ) of all rule weights in the tree. Each rule weight is included as often as the rule is used in the tree. A special case of WCFGs are PCFGs, where the weights are (logarithms of ) probabilities. An extended version of the CYK algorithm can be used to find the "lightest" (least-weight) derivation of a string given some WCFG. When the tree weight is the product of the rule weights, WCFGs and PCFGs can express the same set of probability distributions. == Applications == === RNA structure prediction === Since the 1990s, PCFG has been applied to model RNA structures. Energy minimization and PCFG provide ways of predicting RNA secondary structure with comparable performance. However structure prediction by PCFGs is scored probabilistically rather than by minimum free energy calculation. PCFG model parameters are directly derived from frequencies of different features observed in databases of RNA structures rather than by experimental determination as is the case with energy minimization methods. The types of various structure that can be modeled by a PCFG include long range interactions, pairwise structure and other nested structures. However, pseudoknots can not be modeled. PCFGs extend CFG by assigning probabilities to each production rule. A maximum probability parse tree from the grammar implies a maximum probability structure. Since RNAs preserve their structures over their primary sequence, RNA structure prediction can be guided by combining evolutionary information from comparative sequence analysis with biophysical knowledge about a structure plausibility based on such probabilities. Also search results for structural homologs using PCFG rules are scored according to PCFG derivations probabilities. Therefore, building grammar to model the behavior of base-pairs and single-stranded regions starts with exploring features of structural multiple sequence alignment of related RNAs. S → a S a | b S b | a a | b b {\displaystyle S\to aSa|bSb|aa|bb} The above grammar generates a string in an outside-in fashion, that is the basepair on the furthest extremes of the terminal is derived first. So a string such as a a b a a b a a {\displaystyle aabaabaa} is derived by first generating the distal a's on both sides before moving inwards: S ⇒ a S a ⇒ a a S a a ⇒ a a b S b a a ⇒ a a b a a b a a {\displaystyle S\Rightarrow aSa\Rightarrow aaSaa\Rightarrow aabSbaa\Rightarrow aabaabaa} A PCFG model extendibility allows constraining structure prediction by incorporating expectations about different features of an RNA . Such expectation may reflect for example the propensity for assuming a certain structure by an RNA. However incorporation of too much information may increase PCFG space and memory complexity and it is desirable that a PCFG-based model be as simple as possible. Every possible string x a grammar generates is assigned a probability weight P ( x | θ ) {\displaystyle P(x|\theta )} given the PCFG model θ {\displaystyle \theta } . It follows that the sum of all probabilities to all possible grammar productions is ∑ x P ( x | θ ) = 1 {\displaystyle \sum _{\text{x}}P(x|\theta )=1} . The scores
Nicolò Cesa-Bianchi
Nicolò Cesa-Bianchi (Italian pronunciation: [nikoˈlɔ tˈtʃɛːza ˈbjaŋki]) is an Italian computer scientist and Professor of Computer Science at the Department of Computer Science of the University of Milan. He is a researcher in the field of machine learning, and co-author of the books "Prediction, Learning, and Games" with Gabor Lugosi and "Regret analysis of stochastic and nonstochastic multi-armed bandit problems" with Sébastien Bubeck == Education and career == Cesa-Bianchi graduated in Computer Science from the University of Milan in 1988 where he received a PhD in Computer Science in 1993 supervised by Alberto Bertoni. During his PhD, he visited UC Santa Cruz where he worked with Manfred Warmuth and David Haussler. He did his postdoctoral studies at Graz University of Technology under the supervision of Wolfgang Maass. == Research == His research contributions focus on the following areas: design and analysis of machine learning algorithms, especially in online machine learning algorithms for multi-armed bandit problems, with applications to recommender systems and online auctions graph analytics, with applications to social networks and bioinformatics == Awards and honors == Cesa-Bianchi received a Google Research Award in 2010, a Xerox University Affairs Committee Award in 2011, a Criteo Faculty Award in 2017, a Google Faculty Award in 2018, and a IBM Academic Award in 2021. Since 2023 he is corresponding member of the Accademia dei Lincei.
Moses (machine translation)
Moses is a statistical machine translation engine that can be used to train statistical models of text translation from a source language to a target language, developed by the University of Edinburgh. Moses then allows new source-language text to be decoded using these models to produce automatic translations in the target language. Training requires a parallel corpus of passages in the two languages, typically manually translated sentence pairs. Moses is free and open-source software, released under the GNU Library Public License (LGPL), and available as source code and binary files for Windows and Linux. Its development is supported mainly by the EuroMatrix project, with funding by the European Commission. Among its features are: A beam search algorithm that quickly finds the highest probability translation within a set of choices Phrase-based translation of short text chunks Handles words with multiple factored representations to enable integrating linguistic and other information (e.g., surface form, lemma and morphology, part-of-speech, word class) Decodes ambiguous forms of a source sentence, represented as a confusion network, to support integrating with upstream tools such as speech recognizers Support for large language models (LMs) such as IRSTLM (an exact LM using memory-mapping) and RandLM (an inexact LM based on Bloom filters)
Contextual AI
Contextual AI is an enterprise software company based in Mountain View, California. It develops a platform for building specialized Retrieval-Augmented Generation (RAG) agents for enterprise use. The company was founded in 2023 by Douwe Kiela and Amanpreet Singh, both former AI researchers at Facebook AI Research (FAIR) and Hugging Face. Douwe Kiela previously led the Meta research team that introduced the Retrieval-Augmented Generation (RAG) approach in 2020. Contextual AI focuses on enterprise generative AI applications using RAG 2.0 technology, with deployments primarily in the technology, banking, finance and media sectors. == History == In June 2023, Contextual AI announced it had raised $20 million in a seed funding round led by Bain Capital Ventures (BCV), with participation from Lightspeed Venture Partners, Greycroft, SV Angel, and several angel investors. In August 2024, the company raised $80 million in a Series A funding round led by Greycroft, with participation from previous investors including Bain Capital Ventures, Lightspeed, and Conviction Partners. The round also included new backers such as Bezos Expeditions, NVentures (Nvidia), HSBC Ventures, and Snowflake Ventures. == Features == Retrieval-Augmented Generation (RAG) is an artificial intelligence framework that integrates information retrieval with text generation to improve the performance of large language models (LLMs) on complex, knowledge-intensive tasks. It was introduced in 2020 by researchers at Meta AI, including Douwe Kiela, Patrick Lewis and others, in their paper Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks. RAG enables language models to access and incorporate external information, such as proprietary databases or real-time web content, at query time, instead of relying solely on pre-trained, internal, static knowledge. This architecture addresses common limitations of standard LLMs, including hallucination, outdated information, and lack of attribution to source materials. RAG systems retrieve relevant context through a variety of techniques - including vector search, keyword search, text-to-SQL - and feeds this context into the language model to generate responses. The approach improves factual accuracy, supports domain-specific customization, enables citation of sources, and allows for more updated information without retraining the model itself. General Availability. In January 2025, Contextual AI announced the general availability of its enterprise platform for building specialized RAG agents. Early adopters included Qualcomm, which used the platform for their Customer Engineering team needs. Grounded Language Model. In March 2025, the company introduced a Grounded Language Model (GLM) for factual accuracy in enterprise AI applications. Reranker. In March 2025, Contextual AI released an instruction-following reranker that allows users to influence the ranking of retrieved documents through natural language instructions, such as prioritizing recent files, specific formats, or content from designated sources. == Applications == Contextual AI's platform has been adopted across a range of industries, including finance, technology, media and professional services. Clients include Fortune 500 companies such as Qualcomm and HSBC.
Regina Barzilay
Regina Barzilay (Hebrew: רגינה ברזילי; born 1970) is an Israeli-American computer scientist. She is a professor at the Massachusetts Institute of Technology and a faculty lead for artificial intelligence at the MIT Jameel Clinic. Her research interests are in natural language processing and applications of deep learning to chemistry and oncology. == Early life and education == Barzilay was born in Chișinău, Moldova and emigrated to Israel with her parents at the age of 20. She received bachelor's and master's degrees from Ben-Gurion University of the Negev in 1993 and 1998, respectively. She obtained a PhD in computer science from Columbia University in 2003 for research supervised by Kathleen McKeown. == Career and research == After her PhD, she spent a year as a postdoctoral researcher at Cornell University. She was appointed as Delta Electronics Professor of Electrical Engineering and Computer Science at MIT in 2016. She was diagnosed with breast cancer in 2014, which prompted her to conduct research in oncology. Barzilay won the MacArthur Fellowship in 2017. For her doctoral dissertation at Columbia University, she led the development of Newsblaster, which recognized stories from different news sources as being about the same basic subject, and then paraphrased elements from the stories to create a summary. In computational linguistics, Barzilay created algorithms that learned annotations from common languages (i.e. English) to analyze less understood languages. Prompted by her experience with breast cancer, Barzilay is applying machine learning to oncology. She is collaborating with physicians and students to devise deep learning models that utilize images, text, and structured data to identify trends that affect early diagnosis, treatment, and disease prevention. Frontline Documentary Following her battle with breast cancer in 2014, and her researching into applying artificial intelligence to improve early detection methods, she collaborated with Dr. Connie Lehman at Massachusetts General Hospital. While there Barzilay developed an AI-based system capable of predicting the likelihood of breast cancer up to five years in advance. The system leverages deep learning techniques to analyze mammograms and diagnostic notes, surpassing traditional pattern recognition by human radiologists. This breakthrough, while still in development, has the potential to significantly enhance early diagnosis and treatment outcomes. [1] Barzilay's work in this area was featured in the FRONTLINE documentary In the Age of AI, which explores the broader impact of artificial intelligence on society. === MIT Jameel Clinic === In 2018, Barzilay was appointed faculty lead for AI at the new MIT Jameel Clinic, a research center in the field of AI health sciences, including disease detection, drug discovery, and the development of medical devices. In 2020, she was part of the team—with fellow MIT Jameel Clinic faculty lead Professor James J. Collins—that announced the discovery through deep learning of halicin, the first new antibiotic compound for 30 years, which kills over 35 powerful bacteria, including antimicrobial-resistant tuberculosis, the superbug C. difficile, and two of the World Health Organization's top-three most deadly bacteria. In 2020, Collins, Barzilay and the MIT Jameel Clinic were also awarded funding through The Audacious Project to expand on the discovery of halicin in using AI to respond to the antibiotic resistance crisis through the development of new classes of antibiotics. == Awards and recognition == In 2017, Barzilay won the MacArthur Fellowship, known as the "Genius Grant", for "developing machine learning methods that enable computers to process and analyze vast amounts of human language data." She is also a recipient of various awards including the NSF Career Award, the MIT Technology Review TR-35 Award, Microsoft Faculty Fellowship and several Best Paper Awards at NAACL and ACL. Her teaching has also been recognized by MIT as she won the Jamieson Teaching Award in 2016. She was nominated an AAAI Fellow in 2018 by the Association for the Advancement of Artificial Intelligence. In 2020, she became the first recipient of the $1 million AAAI Squirrel AI Award for Artificial Intelligence for the Benefit of Humanity. In 2023, she was elected to the National Academy of Medicine and the National Academy of Engineering.