AlphaEvolve

AlphaEvolve

AlphaEvolve is an evolutionary coding agent for designing advanced algorithms based on large language models such as Gemini. It was developed by Google DeepMind and unveiled in May 2025. == Design == AlphaEvolve aims to autonomously discover and refine algorithms through a combination of large language models (LLMs) and evolutionary computation. AlphaEvolve needs an evaluation function with metrics to optimize, and an initial algorithm. At each step, AlphaEvolve uses the LLM to produce variants of the existing algorithms, and then selects the most effective ones. Unlike domain-specific predecessors like AlphaFold or AlphaTensor, AlphaEvolve is designed as a general-purpose system. It can operate across a wide array of scientific and engineering tasks by automatically modifying code and optimizing for multiple objectives. Its architecture allows it to evaluate code programmatically, reducing reliance on human input and mitigating risks such as hallucinations common in standard LLM outputs. == Achievements == According to Google, across a selection of 50 open mathematical problems, the model was able to rediscover state-of-the-art solutions 75% of the time and discovered improved solutions 20% of the time, for example advancing the kissing number problem. AlphaEvolve was also used to optimize Google's computing ecosystem. Improved data center scheduling heuristics, enabled the recovery of 0.7% of stranded resources. It was also used to optimize TPU circuit design and Gemini's training matrix multiplication kernel. == Open source implementations == Following the publication of AlphaEvolve, several open source implementations have been developed by the research community. One such implementation is OpenEvolve, which implements distributed evolutionary algorithms, multi-language support, integration with various large language model providers, and automated discovery of high-performance GPU kernels that outperform expert-engineered baselines.

Apache Drill

Apache Drill is an open-source software framework that supports data-intensive distributed applications for interactive analysis of large-scale datasets. Built chiefly by contributions from developers from MapR, Drill is inspired by Google's Dremel system. Drill is an Apache top-level project. Drill supports a variety of NoSQL databases and file systems, including Alluxio, HBase, MongoDB, MapR-DB, HDFS, MapR-FS, Amazon S3, Azure Blob Storage, Google Cloud Storage, Swift, NAS and local files. A single query can join data from multiple datastores. Drill's datastore-aware optimizer automatically restructures a query plan to leverage the datastore's internal processing capabilities. In addition, Drill supports data locality, if Drill and the datastore are on the same nodes. Tom Shiran is the founder of the Apache Drill Project. It was designated an Apache Software Foundation top-level project in December 2016. == Features == One explicitly stated design goal is that Drill is able to scale to 10,000 servers or more and to be able to process petabytes of data and trillions of records in seconds. Schema-free JSON document model similar to MongoDB and Elasticsearch, without requiring a formal schema to be declared Industry-standard APIs: ANSI SQL, ODBC/JDBC, RESTful APIs Extremely user and developer friendly Pluggable architecture enables connectivity to multiple datastores Version 1.9 added dynamic user-defined functions Version 1.11 added cryptographic-related functions and PCAP file format support == Back-end support == Drill is primarily focused on non-relational datastores, including Apache Hadoop text files, NoSQL, and cloud storage. A notable feature also includes in situ querying of local JSON and Apache Parquet files. Some additional datastores that it supports include: All Hadoop distributions (HDFS API 2.3+), including Apache Hadoop, MapR, CDH and Amazon EMR NoSQL: MongoDB, Apache HBase, Apache Cassandra Online Analytical Processing: Apache Kudu, Apache Druid, OpenTSDB Cloud storage: Amazon S3, Google Cloud Storage, Azure Blob Storage, Swift, IBM Cloud Object Storage Diverse data formats, including Apache Avro, Apache Parquet and JSON RDBMs storage plugins (Using JDBC to connect to MySQL, PostgreSQL, and others) A new datastore can be added by developing a storage plugin. Drill's "schema-free" JSON data model enables it to query non-relational datastores in-situ . == Front-end support == Drill itself can be queried via JDBC, ODBC, or REST through a variety of methods and languages including Python and Java. The default install includes a web interface allowing end-users to execute ANSI SQL directly and export data tables as CSV files without any programming. The dashboard library, Apache Superset, is particularly well suited for visualization of data queried with Drill.

Ni1000

The Ni1000 is an artificial neural network chip developed by Nestor Corporation and Intel, developed in the 1990s. It is Intel's second-generation neural network chip, but the first all-digital chip. The chip is aimed at image analysis applications– containing more than 3 million transistors – and can analyze 40,000 patterns per second. Prototypes running Nestor's OCR software in 1994 were capable of recognizing around 100 handwritten characters per second. The development was funded with money from DARPA and Office of Naval Research.

Policy gradient method

Policy gradient methods are a class of reinforcement learning algorithms and a sub-class of policy optimization methods. Unlike value-based methods which learn a value function to derive a policy, policy optimization methods directly learn a policy function π {\displaystyle \pi } that selects actions without consulting a value function. For policy gradient to apply, the policy function π θ {\displaystyle \pi _{\theta }} is parameterized by a differentiable parameter θ {\displaystyle \theta } . == Overview == In policy-based RL, the actor is a parameterized policy function π θ {\displaystyle \pi _{\theta }} , where θ {\displaystyle \theta } are the parameters of the actor. The actor takes as argument the state of the environment s {\displaystyle s} and produces a probability distribution π θ ( ⋅ ∣ s ) {\displaystyle \pi _{\theta }(\cdot \mid s)} . If the action space is discrete, then ∑ a π θ ( a ∣ s ) = 1 {\displaystyle \sum _{a}\pi _{\theta }(a\mid s)=1} . If the action space is continuous, then ∫ a π θ ( a ∣ s ) d a = 1 {\displaystyle \int _{a}\pi _{\theta }(a\mid s)\mathrm {d} a=1} . The goal of policy optimization is to find some θ {\displaystyle \theta } that maximizes the expected episodic reward J ( θ ) {\displaystyle J(\theta )} : J ( θ ) = E π θ [ ∑ t = 0 T γ t R t | S 0 = s 0 ] {\displaystyle J(\theta )=\mathbb {E} _{\pi _{\theta }}\left[\sum _{t=0}^{T}\gamma ^{t}R_{t}{\Big |}S_{0}=s_{0}\right]} where γ {\displaystyle \gamma } is the discount factor, R t {\displaystyle R_{t}} is the reward at step t {\displaystyle t} , s 0 {\displaystyle s_{0}} is the starting state, and T {\displaystyle T} is the time-horizon (which can be infinite). The policy gradient is defined as ∇ θ J ( θ ) {\displaystyle \nabla _{\theta }J(\theta )} . Different policy gradient methods stochastically estimate the policy gradient in different ways. The goal of any policy gradient method is to iteratively maximize J ( θ ) {\displaystyle J(\theta )} by gradient ascent. Since the key part of any policy gradient method is the stochastic estimation of the policy gradient, they are also studied under the title of "Monte Carlo gradient estimation". == REINFORCE == === Policy gradient === The REINFORCE algorithm, introduced by Ronald J. Williams in 1992, was the first policy gradient method. It is based on the identity for the policy gradient ∇ θ J ( θ ) = E π θ [ ∑ t = 0 T ∇ θ ln ⁡ π θ ( A t ∣ S t ) ∑ t = 0 T ( γ t R t ) | S 0 = s 0 ] {\displaystyle \nabla _{\theta }J(\theta )=\mathbb {E} _{\pi _{\theta }}\left[\sum _{t=0}^{T}\nabla _{\theta }\ln \pi _{\theta }(A_{t}\mid S_{t})\;\sum _{t=0}^{T}(\gamma ^{t}R_{t}){\Big |}S_{0}=s_{0}\right]} which can be improved via the "causality trick" ∇ θ J ( θ ) = E π θ [ ∑ t = 0 T ∇ θ ln ⁡ π θ ( A t ∣ S t ) ∑ τ = t T ( γ τ R τ ) | S 0 = s 0 ] {\displaystyle \nabla _{\theta }J(\theta )=\mathbb {E} _{\pi _{\theta }}\left[\sum _{t=0}^{T}\nabla _{\theta }\ln \pi _{\theta }(A_{t}\mid S_{t})\sum _{\tau =t}^{T}(\gamma ^{\tau }R_{\tau }){\Big |}S_{0}=s_{0}\right]} Thus, we have an unbiased estimator of the policy gradient: ∇ θ J ( θ ) ≈ 1 N ∑ n = 1 N [ ∑ t = 0 T ∇ θ ln ⁡ π θ ( A t , n ∣ S t , n ) ∑ τ = t T ( γ τ − t R τ , n ) ] {\displaystyle \nabla _{\theta }J(\theta )\approx {\frac {1}{N}}\sum _{n=1}^{N}\left[\sum _{t=0}^{T}\nabla _{\theta }\ln \pi _{\theta }(A_{t,n}\mid S_{t,n})\sum _{\tau =t}^{T}(\gamma ^{\tau -t}R_{\tau ,n})\right]} where the index n {\displaystyle n} ranges over N {\displaystyle N} rollout trajectories using the policy π θ {\displaystyle \pi _{\theta }} . The score function ∇ θ ln ⁡ π θ ( A t ∣ S t ) {\displaystyle \nabla _{\theta }\ln \pi _{\theta }(A_{t}\mid S_{t})} can be interpreted as the direction in the parameter space that increases the probability of taking action A t {\displaystyle A_{t}} in state S t {\displaystyle S_{t}} . The policy gradient, then, is a weighted average of all possible directions to increase the probability of taking any action in any state, but weighted by reward signals, so that if taking a certain action in a certain state is associated with high reward, then that direction would be highly reinforced, and vice versa. === Algorithm === The REINFORCE algorithm is a loop: Rollout N {\displaystyle N} trajectories in the environment, using π θ t {\displaystyle \pi _{\theta _{t}}} as the policy function. Compute the policy gradient estimation: g i ← 1 N ∑ n = 1 N [ ∑ t = 0 T ∇ θ t ln ⁡ π θ ( A t , n ∣ S t , n ) ∑ τ = t T ( γ τ R τ , n ) ] {\displaystyle g_{i}\leftarrow {\frac {1}{N}}\sum _{n=1}^{N}\left[\sum _{t=0}^{T}\nabla _{\theta _{t}}\ln \pi _{\theta }(A_{t,n}\mid S_{t,n})\sum _{\tau =t}^{T}(\gamma ^{\tau }R_{\tau ,n})\right]} Update the policy by gradient ascent: θ i + 1 ← θ i + α i g i {\displaystyle \theta _{i+1}\leftarrow \theta _{i}+\alpha _{i}g_{i}} Here, α i {\displaystyle \alpha _{i}} is the learning rate at update step i {\displaystyle i} . == Variance reduction == REINFORCE is an on-policy algorithm, meaning that the trajectories used for the update must be sampled from the current policy π θ {\displaystyle \pi _{\theta }} . This can lead to high variance in the updates, as the returns R ( τ ) {\displaystyle R(\tau )} can vary significantly between trajectories. Many variants of REINFORCE have been introduced, under the title of variance reduction. === REINFORCE with baseline === A common way for reducing variance is the REINFORCE with baseline algorithm, based on the following identity: ∇ θ J ( θ ) = E π θ [ ∑ t = 0 T ∇ θ ln ⁡ π θ ( A t | S t ) ( ∑ τ = t T ( γ τ R τ ) − b ( S t ) ) | S 0 = s 0 ] {\displaystyle \nabla _{\theta }J(\theta )=\mathbb {E} _{\pi _{\theta }}\left[\sum _{t=0}^{T}\nabla _{\theta }\ln \pi _{\theta }(A_{t}|S_{t})\left(\sum _{\tau =t}^{T}(\gamma ^{\tau }R_{\tau })-b(S_{t})\right){\Big |}S_{0}=s_{0}\right]} for any function b : States → R {\displaystyle b:{\text{States}}\to \mathbb {R} } . This can be proven by applying the previous lemma. The algorithm uses the modified gradient estimator g i ← 1 N ∑ n = 1 N [ ∑ t = 0 T ∇ θ t ln ⁡ π θ ( A t , n | S t , n ) ( ∑ τ = t T ( γ τ R τ , n ) − b i ( S t , n ) ) ] {\displaystyle g_{i}\leftarrow {\frac {1}{N}}\sum _{n=1}^{N}\left[\sum _{t=0}^{T}\nabla _{\theta _{t}}\ln \pi _{\theta }(A_{t,n}|S_{t,n})\left(\sum _{\tau =t}^{T}(\gamma ^{\tau }R_{\tau ,n})-b_{i}(S_{t,n})\right)\right]} and the original REINFORCE algorithm is the special case where b i ≡ 0 {\displaystyle b_{i}\equiv 0} . === Actor-critic methods === If b i {\textstyle b_{i}} is chosen well, such that b i ( S t ) ≈ ∑ τ = t T ( γ τ R τ ) = γ t V π θ i ( S t ) {\textstyle b_{i}(S_{t})\approx \sum _{\tau =t}^{T}(\gamma ^{\tau }R_{\tau })=\gamma ^{t}V^{\pi _{\theta _{i}}}(S_{t})} , this could significantly decrease variance in the gradient estimation. That is, the baseline should be as close to the value function V π θ i ( S t ) {\displaystyle V^{\pi _{\theta _{i}}}(S_{t})} as possible, approaching the ideal of: ∇ θ J ( θ ) = E π θ [ ∑ t = 0 T ∇ θ ln ⁡ π θ ( A t | S t ) ( ∑ τ = t T ( γ τ R τ ) − γ t V π θ ( S t ) ) | S 0 = s 0 ] {\displaystyle \nabla _{\theta }J(\theta )=\mathbb {E} _{\pi _{\theta }}\left[\sum _{t=0}^{T}\nabla _{\theta }\ln \pi _{\theta }(A_{t}|S_{t})\left(\sum _{\tau =t}^{T}(\gamma ^{\tau }R_{\tau })-\gamma ^{t}V^{\pi _{\theta }}(S_{t})\right){\Big |}S_{0}=s_{0}\right]} Note that, as the policy π θ t {\displaystyle \pi _{\theta _{t}}} updates, the value function V π θ i ( S t ) {\displaystyle V^{\pi _{\theta _{i}}}(S_{t})} updates as well, so the baseline should also be updated. One common approach is to train a separate function that estimates the value function, and use that as the baseline. This is one of the actor-critic methods, where the policy function is the actor and the value function is the critic. The Q-function Q π {\displaystyle Q^{\pi }} can also be used as the critic, since ∇ θ J ( θ ) = E π θ [ ∑ 0 ≤ t ≤ T γ t ∇ θ ln ⁡ π θ ( A t | S t ) ⋅ Q π θ ( S t , A t ) | S 0 = s 0 ] {\displaystyle \nabla _{\theta }J(\theta )=E_{\pi _{\theta }}\left[\sum _{0\leq t\leq T}\gamma ^{t}\nabla _{\theta }\ln \pi _{\theta }(A_{t}|S_{t})\cdot Q^{\pi _{\theta }}(S_{t},A_{t}){\Big |}S_{0}=s_{0}\right]} by a similar argument using the tower law. Subtracting the value function as a baseline, we find that the advantage function A π ( S , A ) = Q π ( S , A ) − V π ( S ) {\displaystyle A^{\pi }(S,A)=Q^{\pi }(S,A)-V^{\pi }(S)} can be used as the critic as well: ∇ θ J ( θ ) = E π θ [ ∑ 0 ≤ t ≤ T γ t ∇ θ ln ⁡ π θ ( A t | S t ) ⋅ A π θ ( S t , A t ) | S 0 = s 0 ] {\displaystyle \nabla _{\theta }J(\theta )=E_{\pi _{\theta }}\left[\sum _{0\leq t\leq T}\gamma ^{t}\nabla _{\theta }\ln \pi _{\theta }(A_{t}|S_{t})\cdot A^{\pi _{\theta }}(S_{t},A_{t}){\Big |}S_{0}=s_{0}\right]} In summary, there are many unbiased estimators for ∇ θ J θ {\textstyle \nabla _{\theta }J_{\theta }} , all in the form of: ∇ θ J ( θ ) = E π θ [ ∑ 0 ≤ t ≤ T ∇ θ ln ⁡ π θ ( A t | S t ) ⋅ Ψ t | S 0 = s 0 ] {\displaystyle \nabla _{\theta }J(\theta )=E_{\pi _{\theta }}\left[\su

Targeted maximum likelihood estimation

Targeted Maximum Likelihood Estimation (TMLE) (also more accurately referred to as Targeted Minimum Loss-Based Estimation) is a general statistical estimation framework for causal inference and semiparametric models. TMLE combines ideas from maximum likelihood estimation, semiparametric efficiency theory, and machine learning. It was introduced by Mark J. van der Laan and colleagues in the mid-2000s as a method that yields asymptotically efficient plug-in estimators while allowing the use of flexible, data-adaptive algorithms such as ensemble machine learning for nuisance parameter estimation. TMLE is used in epidemiology, biostatistics, and the social sciences to estimate causal effects in observational and experimental studies. Applications of TMLE include Longitudinal TMLE (LTMLE) for time-varying treatments and confounders. Variations in how the targeting step in TMLE is carried out have resulted in various versions of TMLE such as Collaborative TMLE (CTMLE) and Adaptive TMLE for improved finite-sample performance and automated variable selection. == History == The TMLE framework was first described by van der Laan and Rubin (2006) as a general approach for the construction of efficient plug-in estimators of smooth features of the data density. It was demonstrated in the context of causal inference and missing data problems. It was developed to address limitations of traditional doubly robust methods, such as Augmented Inverse Probability Weighting (AIPW), by respecting the plug-in principle in the sense that it respects that the target parameter is a function of the data density that is an element of the statistical model. TMLE estimates the data density or relevant parts of it with machine learning and targets these machine learning fits before it is plugged in the target parameter mapping. In this manner, a TMLE always respects global knowledge and satisfies known bounds such as that the target parameter is a probability . Since its introduction, TMLE has been developed in a series of theoretical and applied papers, culminating in book-length treatments of the method and its applications to survival analysis, adaptive designs, and longitudinal data. == Methodology == At its core, TMLE is a two-step estimation procedure: Initial estimation: Machine learning methods (such as the Super Learner ensemble) are used to obtain flexible estimates of nuisance parameters, such as outcome regressions and propensity scores. Targeting step: The initial estimate is updated by solving a score equation (the efficient influence function) so that the final estimator is consistent, asymptotically normal, and efficient under mild regularity conditions. The targeted machine learning fit is then mapped into the corresponding estimator of the target parameter by simply plugging it in the target parameter mapping. This approach balances the bias–variance trade-off by combining data-adaptive estimation with semiparametric efficiency theory. TMLE is doubly robust, meaning it remains consistent if either the outcome model or the treatment model is consistently estimated. === Formula === Here we explain the TMLE of the average treatment effect of a binary treatment on an outcome adjusting for baseline covariates. Consider i.i.d. observations O i = ( W i , A i , Y i ) {\displaystyle O_{i}=(W_{i},A_{i},Y_{i})} from a distribution P 0 {\displaystyle P_{0}} , where W {\displaystyle W} are baseline covariates, A {\displaystyle A} is a binary treatment, and Y {\displaystyle Y} is an outcome. Let Q ¯ ( a , w ) = E [ Y ∣ A = a , W = w ] {\displaystyle {\bar {Q}}(a,w)=\mathbb {E} [Y\mid A=a,W=w]} represent the outcome model and g ( a ∣ w ) = P ( A = a ∣ W = w ) {\displaystyle g(a\mid w)=P(A=a\mid W=w)} represent the propensity score. The average treatment effect (ATE) is given by ψ 0 = E { Q ¯ ( 1 , W ) − Q ¯ ( 0 , W ) } . {\displaystyle \psi _{0}=\mathbb {E} \{{\bar {Q}}(1,W)-{\bar {Q}}(0,W)\}.} A basic TMLE for the ATE proceeds as follows: Step 1: Estimate initial models. Obtain estimates Q ¯ ^ ( a , w ) {\displaystyle {\hat {\bar {Q}}}(a,w)} and g ^ ( a ∣ w ) {\displaystyle {\hat {g}}(a\mid w)} , often using flexible methods such as Super Learner. Step 2: Compute the clever covariate. Define: H ( A , W ) = A g ^ ( 1 ∣ W ) − 1 − A g ^ ( 0 ∣ W ) . {\displaystyle H(A,W)={\frac {A}{{\hat {g}}(1\mid W)}}-{\frac {1-A}{{\hat {g}}(0\mid W)}}.} Step 3: Estimate the fluctuation parameter. Fit a logistic regression of Y {\displaystyle Y} on H ( A , W ) {\displaystyle H(A,W)} with logit ⁡ ( Q ¯ ^ ( A , W ) ) {\displaystyle \operatorname {logit} ({\hat {\bar {Q}}}(A,W))} as offset. This yields ε ^ {\displaystyle {\hat {\varepsilon }}} , the MLE that solves the score equation: 1 n ∑ i = 1 n H ( A i , W i ) { Y i − Q ¯ ^ ε ( A i , W i ) } = 0. {\displaystyle {\frac {1}{n}}\sum _{i=1}^{n}H(A_{i},W_{i}){\big \{}Y_{i}-{\hat {\bar {Q}}}^{\varepsilon }(A_{i},W_{i}){\big \}}=0.} Step 4: Update the initial estimate. Apply the "blip" to obtain the targeted estimate: Q ¯ ^ ∗ ( A , W ) = expit ⁡ ( logit ⁡ ( Q ¯ ^ ( A , W ) ) + ε ^ H ( A , W ) ) . {\displaystyle {\hat {\bar {Q}}}^{}(A,W)=\operatorname {expit} {\Big (}\operatorname {logit} {\big (}{\hat {\bar {Q}}}(A,W){\big )}+{\hat {\varepsilon }}\,H(A,W){\Big )}.} Step 5: Compute the TMLE. The ATE estimate is: ψ ^ TMLE = 1 n ∑ i = 1 n [ Q ¯ ^ ∗ ( 1 , W i ) − Q ¯ ^ ∗ ( 0 , W i ) ] . {\displaystyle {\hat {\psi }}_{\text{TMLE}}={\frac {1}{n}}\sum _{i=1}^{n}{\big [}{\hat {\bar {Q}}}^{}(1,W_{i})-{\hat {\bar {Q}}}^{}(0,W_{i}){\big ]}.} Inference. The efficient influence function (EIF) for the ATE is: D ∗ ( O ) = H ( A , W ) { Y − Q ¯ ∗ ( A , W ) } + Q ¯ ∗ ( 1 , W ) − Q ¯ ∗ ( 0 , W ) − ψ . {\displaystyle D^{}(O)=H(A,W)\{Y-{\bar {Q}}^{}(A,W)\}+{\bar {Q}}^{}(1,W)-{\bar {Q}}^{}(0,W)-\psi .} The variance is estimated by σ ^ 2 = n − 1 ∑ i = 1 n ( D ∗ ( O i ) ) 2 {\displaystyle {\hat {\sigma }}^{2}=n^{-1}\sum _{i=1}^{n}{\big (}D^{}(O_{i}){\big )}^{2}} , yielding Wald-type confidence intervals ψ ^ TMLE ± z 1 − α / 2 σ ^ / n {\displaystyle {\hat {\psi }}_{\text{TMLE}}\pm z_{1-\alpha /2}\,{\hat {\sigma }}/{\sqrt {n}}} . Remark. For continuous outcomes, a linear fluctuation Q ¯ ^ ∗ = Q ¯ ^ + ε ^ H {\displaystyle {\hat {\bar {Q}}}^{}={\hat {\bar {Q}}}+{\hat {\varepsilon }}\,H} may be used instead. For bounded continuous outcomes, the logistic fluctuation (after rescaling Y {\displaystyle Y} to [ 0 , 1 ] {\displaystyle [0,1]} ) is often preferred for improved finite-sample performance. == Applications == TMLE has been applied in: Epidemiology: Estimating causal effects of exposures and interventions in observational cohort studies. Clinical trials and real-world evidence: The Targeted Learning roadmap provides a structured framework for generating and validating real-world evidence (RWE), bridging randomized trials and observational data using TMLE and related estimation techniques. This approach enables transparency, sensitivity analysis, and stronger causal inference for regulatory and clinical trial contexts. High-dimensional settings: Integration with ensemble methods for causal effect estimation. TMLE has been successfully applied in pharmacoepidemiology where a large number of covariates are automatically selected to adjust for confounding. In a study of post–myocardial infarction statin use and 1-year mortality, TMLE demonstrated robust performance relative to inverse probability weighting in scenarios with hundreds of potential confounders. == Derivatives and extensions == Longitudinal TMLE (LTMLE): A methodological extension of TMLE for longitudinal data with time-varying treatments, confounders, and censoring. It allows the estimation of dynamic treatment regimes and intervention-specific causal effects over time. This framework was originally introduced by van der Laan & Gruber (2012). Collaborative TMLE (CTMLE): Enhances finite-sample performance and variable selection by collaboratively fitting the treatment mechanism in conjunction with the target parameter. == Software == Several R packages implement TMLE and related methods: tmle: Functions for binary, categorical, and continuous outcomes. ltmle: Implementation for longitudinal data with time-varying treatments and outcomes. ctmle: Algorithms for collaborative TMLE and adaptive variable selection. SuperLearner: A theoretically grounded, cross-validated ensemble learning method that combines predictions from multiple algorithms to minimize predictive risk. Widely used in TMLE for estimating nuisance parameters. The original implementation is available as the R package SuperLearner. Recent machine learning platforms like H2O AutoML implement similar ensemble strategies, combining diverse learners in parallel and leveraging stacking and blending techniques, effectively functioning as a large-scale Super Learner.

AppyStore

AppyStore is a comprehensive learning videos and games app for kids up to the age of 8 years. The platform developed by Mauj Mobile, a mobile value-added services (VAS) provider curates content to help in child development by leveraging technology. Mauj is funded by Sequoia Capital, Westbridge Capital and Intel Capital. == Background == AppyStore was launched in 2014 as a platform providing content for kids between the ages of 1.5 and 6 years. AppyStore subsequently extended its services for kids up to 8 years of age. The company operates on a subscription-based model and claims to have 5,000 learning games and videos segregated in 18 learning areas developed to help children gain optimal skills and qualities. According to an article published in Business Standard, the application is claimed to be one of the top 5 apps that help to enhance the logical and imaginative capabilities of children. AppyStore was awarded the Best app for kids by Google Play in December 2017. == Service == The company provides content via a website and an Android app. The website and android app provide learning games, rhymes, phonics, reading, stories, science, numbers, maths, logic videos comprising puzzles, worksheets, videos and fun activities and the premium subscription also includes physical worksheets which are home delivered. This content is educational and has been handpicked by teachers and experts with an understanding of the major areas of child development milestones for children up to 8 years of age. The mobile application also allows parents to track the progress of their child on the basis of the number of videos viewed.

Multidimensional analysis

In statistics, econometrics and related fields, multidimensional analysis (MDA) is a data analysis process that groups data into two categories: data dimensions and measurements. For example, a data set consisting of the number of wins for a single football team at each of several years is a single-dimensional (in this case, longitudinal) data set. A data set consisting of the number of wins for several football teams in a single year is also a single-dimensional (in this case, cross-sectional) data set. A data set consisting of the number of wins for several football teams over several years is a two-dimensional data set. == Higher dimensions == In many disciplines, two-dimensional data sets are also called panel data. While, strictly speaking, two- and higher-dimensional data sets are "multi-dimensional", the term "multidimensional" tends to be applied only to data sets with three or more dimensions. For example, some forecast data sets provide forecasts for multiple target periods, conducted by multiple forecasters, and made at multiple horizons. The three dimensions provide more information than can be gleaned from two-dimensional panel data sets. == Software == Computer software for MDA include Online analytical processing (OLAP) for data in relational databases, pivot tables for data in spreadsheets, and Array DBMSs for general multi-dimensional data (such as raster data) in science, engineering, and business.