Algorithm engineering focuses on the design, analysis, implementation, optimization, profiling and experimental evaluation of computer algorithms, bridging the gap between algorithmics theory and practical applications of algorithms in software engineering. It is a general methodology for algorithmic research. == Origins == In 1995, a report from an NSF-sponsored workshop "with the purpose of assessing the current goals and directions of the Theory of Computing (TOC) community" identified the slow speed of adoption of theoretical insights by practitioners as an important issue and suggested measures to reduce the uncertainty by practitioners whether a certain theoretical breakthrough will translate into practical gains in their field of work, and tackle the lack of ready-to-use algorithm libraries, which provide stable, bug-free and well-tested implementations for algorithmic problems and expose an easy-to-use interface for library consumers. But also, promising algorithmic approaches have been neglected due to difficulties in mathematical analysis. The term "algorithm engineering" was first used with specificity in 1997, with the first Workshop on Algorithm Engineering (WAE97), organized by Giuseppe F. Italiano. == Difference from algorithm theory == Algorithm engineering does not intend to replace or compete with algorithm theory, but tries to enrich, refine and reinforce its formal approaches with experimental algorithmics (also called empirical algorithmics). This way it can provide new insights into the efficiency and performance of algorithms in cases where the algorithm at hand is less amenable to algorithm theoretic analysis, formal analysis pessimistically suggests bounds which are unlikely to appear on inputs of practical interest, the algorithm relies on the intricacies of modern hardware architectures like data locality, branch prediction, instruction stalls, instruction latencies which the machine model used in Algorithm Theory is unable to capture in the required detail, the crossover between competing algorithms with different constant costs and asymptotic behaviors needs to be determined. == Methodology == Some researchers describe algorithm engineering's methodology as a cycle consisting of algorithm design, analysis, implementation and experimental evaluation, joined by further aspects like machine models or realistic inputs. They argue that equating algorithm engineering with experimental algorithmics is too limited, because viewing design and analysis, implementation and experimentation as separate activities ignores the crucial feedback loop between those elements of algorithm engineering. === Realistic models and real inputs === While specific applications are outside the methodology of algorithm engineering, they play an important role in shaping realistic models of the problem and the underlying machine, and supply real inputs and other design parameters for experiments. === Design === Compared to algorithm theory, which usually focuses on the asymptotic behavior of algorithms, algorithm engineers need to keep further requirements in mind: Simplicity of the algorithm, implementability in programming languages on real hardware, and allowing code reuse. Additionally, constant factors of algorithms have such a considerable impact on real-world inputs that sometimes an algorithm with worse asymptotic behavior performs better in practice due to lower constant factors. === Analysis === Some problems can be solved with heuristics and randomized algorithms in a simpler and more efficient fashion than with deterministic algorithms. Unfortunately, this makes even simple randomized algorithms difficult to analyze because there are subtle dependencies to be taken into account. === Implementation === Huge semantic gaps between theoretical insights, formulated algorithms, programming languages and hardware pose a challenge to efficient implementations of even simple algorithms, because small implementation details can have rippling effects on execution behavior. The only reliable way to compare several implementations of an algorithm is to spend an considerable amount of time on tuning and profiling, running those algorithms on multiple architectures, and looking at the generated machine code. === Experiments === See: Experimental algorithmics === Application engineering === Implementations of algorithms used for experiments differ in significant ways from code usable in applications. While the former prioritizes fast prototyping, performance and instrumentation for measurements during experiments, the latter requires thorough testing, maintainability, simplicity, and tuning for particular classes of inputs. === Algorithm libraries === Stable, well-tested algorithm libraries like LEDA play an important role in technology transfer by speeding up the adoption of new algorithms in applications. Such libraries reduce the required investment and risk for practitioners, because it removes the burden of understanding and implementing the results of academic research. == Conferences == Two main conferences on Algorithm Engineering are organized annually, namely: Symposium on Experimental Algorithms (SEA), established in 1997 (formerly known as WEA). SIAM Meeting on Algorithm Engineering and Experiments (ALENEX), established in 1999. The 1997 Workshop on Algorithm Engineering (WAE'97) was held in Venice (Italy) on September 11–13, 1997. The Third International Workshop on Algorithm Engineering (WAE'99) was held in London, UK in July 1999. The first Workshop on Algorithm Engineering and Experimentation (ALENEX99) was held in Baltimore, Maryland on January 15–16, 1999. It was sponsored by DIMACS, the Center for Discrete Mathematics and Theoretical Computer Science (at Rutgers University), with additional support from SIGACT, the ACM Special Interest Group on Algorithms and Computation Theory, and SIAM, the Society for Industrial and Applied Mathematics.
The Cancer Imaging Archive
The Cancer Imaging Archive (TCIA) is an open-access database of medical images for cancer research. The site is funded by the National Cancer Institute's (NCI) Cancer Imaging Program, and the contract is operated by the University of Arkansas for Medical Sciences. Data within the archive is organized into collections which typically share a common cancer type and/or anatomical site. The majority of the data consists of CT, MRI, and nuclear medicine (e.g. PET) images stored in DICOM format, but many other types of supporting data are also provided or linked to, in order to enhance research utility. All data are de-identified in order to comply with the Health Insurance Portability and Accountability Act and National Institutes of Health data sharing policies. TCIA resources are intended to support: Development of computer aided diagnosis methods (quantitative imaging) Evaluation of unbiased science reproducibility by acceptable standard statistical methods Research on correlation of clinical diagnostic medical images with digital microscopic histological images Exploratory biomarker research for which imaging is a key element Collaboration between cross-disciplinary investigators where imaging is crucial to research on tumor heterogeneity, between patients and within the tumor; tissue temporal response tracking - objective measurements of tumor progression; imaging genomics and Big Data linkages and analysis (clinical, histo-pathology, genomics) TCIA is recognized as a recommended repository for the Scientific Data, PLOS One, and F1000Research journals. It is also listed in the Registry of Research Data Repositories. == History == Prior to the creation of TCIA, the NCI funded development of the National Biomedical Imaging Archive. NBIA is an open-source Web application which was designed to allow the storage and query of DICOM images. TCIA was subsequently initiated in December 2010 to expand data sharing activities by funding a service component which would help address the technical and policy challenges associated with medical imaging research. TCIA leverages open-source tools such as NBIA and Clinical Trials Processor in order to provide its services. == Organization of the archive == The site content is organized into five categories: About Us - Provides a general overview of the site the organizations responsible for operating it. Share Your Data - Provides an overview of how to apply to upload data to the archive. Access the Archive - Provides information about the available data, methods for accessing that data and system usage metrics. Research Activities - Provides information about major research initiatives being conducted using TCIA data as well as information about publication guidelines. Help - Provides information about how to get support using the archive as well as documentation and data usage policies. == Methods for accessing data == Most collections on the Cancer Imaging Archive can be accessed without an account, but a few are restricted to specific users and therefore require an account to access them. TCIA has several ways to browse, filter, and download data. They include: Downloading the entire contents of a collection in bulk Leveraging the NBIA application to filter or search within or across collections Utilizing the RESTful Application programming interface to filter or search within or across collections === Browsing, bulk downloading and access to supporting data === The home page includes a list of all available collections. Basic information about the data such as the cancer type, cancer location, modalities, and number of subjects are also provided. Clicking on a collection name presents a page which describes the data including its original research purpose, how the data were generated, and how it might be useful to other TCIA users. For example, doi:10.7937/K9/TCIA.2015.L4FRET6Z describes the NSCLC-Radiomics-Genomics Collection. In the lower section of the page there are links to search or download the images and any available supporting data in the Data Access tab. Additional tabs provide information about data versions and how to cite the data if used in publications. Many collections contain additional data types such as genomics, patient demographics, treatment details, and expert analyses of the images. This data is usually only found by browsing the collection pages as opposed to searching in NBIA or using the API. === Filtering or searching with NBIA === On each Collection page and also in the main menu of the site there are links to "Search TCIA". This will load the NBIA application which allows simple, advanced and free text searches. Search results follow the conventional DICOM hierarchy of patient -> study -> series. TCIA provides comprehensive documentation on the various features of the NBIA software. === RESTful API === A number of search and download commands are also available through the API. New iterations on the API are released as new versions, so that existing applications developed against older versions of the API continue to function. == Research activities == A list of known publications based on TCIA data is maintained as a convenience to researchers who might want to investigate how it has been used previously. In addition to peer-reviewed publications there are also several major research initiatives described in the Research Activities section of the site. === The CIP TCGA Radiology Initiative for Radiogenomics Research === A large number of collections contain subjects which were analyzed as part of the NIH/NHGRI database known as The Cancer Genome Atlas (TCGA). This offers researchers the ability to correlate clinical images using shared unique identifiers each study that has in TCGA extensive genomic analysis, digital pathology slides and bulk download of individual demographic data and clinical data. A multi-institutional network of investigators volunteering their time is using the data to develop methods to determine prognosis or predict the response to therapy. TCGA collections are designated by nomenclature shared by the TCGA Data Portal (e.g.: TCGA-BRCA, TCGA-GBM, etc). They are subject to a special publication policy which is unique from the other public data on TCIA. === Challenge competitions === TCIA also provides specific data sets used for "Challenge" competitions such as international digital image-focused professional societies like MICCAI, SPIE, or ISBI. A directory of previous and upcoming challenges is maintained on the site. === Digital object identifiers === To facilitate data sharing, many publications encourage authors to include data citations to the data that the authors used in creating the results described in their scholarly papers. In addition, new journals are now available for describing data collections outright (e.g., Nature Scientific Data). TCIA assigns digital object identifiers (DOIs) to all collections when they are submitted, and also has the ability to create persistent identifiers linked to subsets of data held within TCIA that authors may use for data citations in their scholarly papers.
Liang Wenfeng
Liang Wenfeng (Chinese: 梁文锋; pinyin: Liáng Wénfēng; born 1985) is a Chinese entrepreneur and businessman who is the co-founder of the quantitative hedge fund High-Flyer, as well as the founder and CEO of its artificial intelligence company DeepSeek. Liang attended Zhejiang University, and began his career by applying machine learning methods to quantitative finance. Through High-Flyer, he built large-scale computing infrastructure that was later used to support artificial intelligence research, leading to the creation of DeepSeek in 2023. DeepSeek gained international attention following the release of DeepSeek-R1, which analysts described as demonstrating high-level performance with comparatively limited compute resources. In 2025, Liang was named to Time magazine's list of 100 Most Influential People in AI and Fortune's list of the Most Powerful People in Business. == Early life == Liang was born in 1985 in the village of Mililing (米历岭村), Qinba town (覃巴镇), Wuchuan city (吴川市), Guangdong. His parents were both primary school teachers. Liang was routinely praised by both locals and teachers alike. Even since middle school, Liang was recalled for being well-known for reading comic books, while also being very proficient in mathematics. == Education == After elementary school, Liang attended Wuchuan No. 1 Middle School. There, he quickly excelled in class and ranked highly amongst his peers. He taught himself high school and university-level mathematics courses. Liang then attended Wuchaun No. 1 High School. In these years, he developed hobbies of mathematical modeling and conducting research projects. Compared to his peers, he was always ranked highly. For every mathematics exam, he always ranked within the top three. He was also the top scorer in the Zhanjiang region of Guangdong for the college entrance exam. Thus, in 2002, Liang left high school early to further pursue his education at the university level at the young age of 17. Attending Zhejiang University at the age of 17, Liang earned a Bachelor of Engineering in Electronic Information Engineering in 2007 and his Master of Engineering in Information & Communication Engineering in 2010. His master's dissertation was titled "Study on Object Tracking Algorithm Based on Low-Cost PTZ camera" (基于低成本PTZ摄像机的目标跟踪算法研究). In his college years, DJI founder Wang Tao asked Liang to join as a co-founder. Liang declined the invitation to pursue artificial intelligence methodologies in financial markets. While he states that those around him had entrepreneurial mindsets, he himself valued academics. == Career == === Early career (2008–2016) === During the 2008 financial crisis, Liang formed a team with his classmates to accumulate data related to financial markets. He also led the team to explore quantitative trading using machine learning and other technologies. After his graduation, Liang moved to a cheap flat in Chengdu, Sichuan, where he experimented with ways to apply AI to various fields. These ventures failed, until he tried applying AI to finance. In 2013, Liang attempted to integrate artificial intelligence with quantitative trading and founded Hangzhou Yakebi Investment Management Co Ltd with Xu Jin, an alumnus of Zhejiang University. In 2015, they co-founded Hangzhou Huanfang Technology Co Ltd, which is today's Zhejiang Jiuzhang Asset Management Co Ltd. === High-Flyer (2016–2023) === In February 2016, Liang and two other engineering classmates co-founded Ningbo High-Flyer Quantitative Investment Management Partnership (Limited Partnership). The team relied on mathematics and AI to make investments. Much of the early startup culture was described by former employees to be "geeky" and "quirky," often seen as contrary to the existing culture in large Chinese tech companies. In 2019, Liang founded High-Flyer AI which was dedicated to research on AI algorithms and its basic applications. By this time, High-Flyer had over 10 billion yuan in assets under management. On 30 August 2019, Liang Wenfeng delivered a keynote speech entitled "The Future of Quantitative Investment in China from a Programmer's Perspective" at the Private Equity Golden Bull Award ceremony held by China Securities Journal, and sparked heated discussions. Liang stated that the criterion for determining what is quantitative or non-quantitative is whether the investment decision is made by quantitative methods or by people. Quantitative funds do not have portfolio managers making the decisions and instead are just servers. He also stated High-Flyer's mission is to improve the effectiveness of China's secondary market. In February 2021, Gregory Zuckerman's book The Man Who Solved the Market: How Jim Simons Launched the Quant Revolution was published. Liang wrote the preface for the Chinese edition of the book where he stated that whenever he encountered difficulties at work, he would think of Simons' words "There must be a way to model prices". In January 2025, Zuckerman wrote in The Wall Street Journal where he acknowledged this fact and stated he has been trying to get in touch with Liang but much like Simons, Liang is very secretive and difficult to contact. During 2021, Liang started buying thousands of Nvidia GPUs for his AI side project while running High-Flyer. Liang wanted to build something and it will be a game changer which his business partners thought was only possible from giants such as ByteDance and Alibaba Group. === DeepSeek (since 2023) === ==== DeepSeek begins ==== In May 2023, Liang announced High-Flyer would pursue the development of artificial general intelligence and launched DeepSeek. During that month in an interview with 36Kr, Liang stated that High-Flyer had acquired 10,000 Nvidia A100 GPUs before the US government imposed AI chip restrictions on China. That laid the foundation for DeepSeek to operate as an LLM developer. Liang also stated DeepSeek gets funding from High-Flyer. This was because when DeepSeek was founded, venture capital firms were reluctant in providing funding as it was unlikely that it would be able to generate an exit in a short period of time. Liang only personally holds 1% of the company, with 99% of the company being held by Ningbo High-Flyer Quantitative Investment Management Partnership (Limited Partnership). With DeepSeek's funding model, it lacks commercial pressure and rigid key performance indicators, enabling the company to deviate from previously established model architectures. ==== Early development ==== In July 2024, Liang was interviewed again by 36Kr. He stated that when DeepSeek-V2 was released and triggered an AI price war in China, it came as a huge surprise as the team did not expect pricing to be so sensitive. Liang's aggressive pricing of the language model forced domestic tech giants including Alibaba and Baidu to cut their own rates by over 95%. He also stated that as China's economy develops, it should gradually become a contributor instead of freeriding. What is lacking in China's innovation is not capital but a lack of confidence and knowledge on organizing talent into it. DeepSeek has not hired anyone particularly special and employees tend to be locally educated. When it comes to disruptive technologies, closed source approaches can only temporarily delay others in catching up. As the goal was long-term, DeepSeek sought employees who had ability and passion rather than experience. To retain a high talent density relative to larger firms like Bytedance or Baidu, DeepSeek aimed to maintain a low-hierarchy corporate culture, with members working in project-based groups, as well as competitive compensation. Liang emphasized his vision for DeepSeek employees to bring their "unique experience and ideas" instead of needing to be explicitly directed, with an overall bottom-up approach to division of labor. Liang noted that a significant outcome of this approach was the multi-head latent attention training architecture, which was attributed directly to a young DeepSeek researcher's personal interest. This advancement played a core role in reducing the cost of training the DeepSeek-V3 model, released in December 2024. ==== Release of DeepSeek-R1 ==== Also on 20 January 2025, DeepSeek, the company Liang founded and served as the CEO, released DeepSeek-R1, a 671-billion-parameter open-source reasoning AI model, alongside the publication of a detailed technical paper explaining its architecture and training methodology. The model was built using just 2,048 Nvidia H800 GPUs at a cost of $5.6 million, showcasing a resource-efficient approach that contrasted sharply with the billion-dollar budgets of Western competitors. The development of DeepSeek-R1 occurred amidst U.S. sanctions where Trump limited sales of Nvidia chips to China. By 27 January, DeepSeek surpassed ChatGPT to become the #1 free app on the United States iOS App Store. U.S. stocks plummeted, as more than $1 trillion was erased in market capitalization amid panic over DeepSeek. Technology journ
Stewart Nelson
Stewart Nelson is an American mathematician and programmer from The Bronx who co-founded Systems Concepts. == Biography == From a young age, Nelson was tinkering with electronics, aided and abetted by his father who was a physicist that had become an engineer. Stewart attended Poughkeepsie High School, graduating in the spring of 1963. From his first few days of High School, Stewart displayed his talents for hacking the international telephone trunk lines, along with an uncanny skill for picking combination locks, although this was always done as innocent entertainment. He simply loved the challenge of seeing how quickly he could accomplish this feat. His quirky sense of humor was always visible, as was his disdain for any rule that got in the way of his gaining knowledge. Stewart was an inspiration to the school's Tech-elec Club, as well as a ringleader in the founding of the school's pirate radio station. Nelson enrolled at MIT in 1963 and quickly became known for hooking up the AI Lab's PDP-1 (and later the PDP-6) to the telephone network, making him one of the first phreakers. Nelson later accomplished other feats like hard-wiring additional instructions into the PDP-1. Nelson was hired by Ed Fredkin's Information International Inc. at the urging of Marvin Minsky to work on PDP-7 programs at the MIT Computer Science and Artificial Intelligence Laboratory. Nelson was known as a brilliant software programmer. He was influential in LISP, the assembly instructions for the Digital Equipment Corporation PDP, and a number of other systems. The group of young hackers was known for working on systems after hours. One night, Nelson and others decided to rewire MIT's PDP-1 as a prank. Later, Margaret Hamilton tried to use the DEC-supplied DECAL assembler on the machine and it crashed repeatedly.
ITools Resourceome
iTools is a distributed infrastructure for managing, discovery, comparison and integration of computational biology resources. iTools employs Biositemap technology to retrieve and service meta-data about diverse bioinformatics data services, tools, and web-services. iTools is developed by the National Centers for Biomedical Computing as part of the NIH Road Map Initiative.
Xiaomi MiMo
Xiaomi MiMo is a family of large language models (LLMs) developed by Xiaomi. It was initially released in April 2025 with the MiMo-7B model. Currently, MiMo is available for developers through API service. It is used as the key AI model in Xiaomi's "Human x Car x Home" ecosystem. == Development == Xiaomi developed MiMo as a reasoning-focused language model. Its development team was led by Luo Fuli, who had previously worked at DeepSeek before joining Xiaomi in late 2025. The model was trained using multi-token prediction and reinforcement learning, with a particular emphasis on mathematical reasoning and code generation tasks. In March 2026, Xiaomi CEO Lei Jun announced that the company planned to invest at least US$8.7 billion in artificial intelligence over the following three years. == Models == === List of models === === MiMo-7B === MiMo-7B is the first model of this LLM. The base model, MiMo-7B-Base, was pre-trained on approximately 25 trillion tokens using web pages, academic papers, books, and synthetic reasoning data. MiMo-7B-RL underwent supervised fine-tuning and reinforcement learning on 130,000 mathematics and code problems. MiMo-7B-RL-0530 was released in May 2025. It scaled the fine-tuning dataset from 500,000 to 6 million instances and extended the RL window from 32,000 to 48,000 tokens and improved AIME 2024 scores from 68.2 to 80.1. MiMo-VL-7B was a vision-language model combining a Vision Transformer encoder with the MiMo-7B backbone. It was trained in four stages consuming 2.4 trillion tokens. Its reinforcement learning variant used Mixed On-Policy Reinforcement Learning (MORL) which integrated reward signals across perception, grounding, and reasoning. Xiaomi also released MiMo-Audio-7B, an audio-language model for voice conversion, style transfer, and speech editing. === MiMo-V2-Flash === MiMo-V2-Flash was launched in December 2025. It is a open-sourced Mixture-of-experts model with 309 billion total parameters and 15 billion active parameters. It was trained on 27 trillion tokens using FP8 mixed precision. It used hybrid attention interleaving Sliding Window and Global Attention at a 5:1 ratio. === MiMo-V2-Pro === Xiaomi publicly introduced MiMo-V2-Pro on 18 March 2026. It has over 1 trillion total parameters, 42 billion active, and a 1-million-token context window. Before the official release, the model had appeared anonymously on OpenRouter under the codename "Hunter Alpha," where it drew substantial usage and topped daily charts for several days, according to Xiaomi and Reuters. During its listing on OpenRouter, the model reportedly processed over one trillion tokens in total usage. Xiaomi later said Hunter Alpha was an early internal test build of MiMo-V2-Pro, and Reuters reported that the model had been mistaken by some users for a possible DeepSeek system before Xiaomi confirmed its origin. The model was released as a proprietary API product, and Luo Fuli stated that Xiaomi intended to open-source a variant at an unspecified future date. Xiaomi has partnered with several API web platforms like OpenClaw to launch the model. All these websites initially offered a free trial of this model for a week, but due to the overwhelming response, Xiaomi later extended the free trial period of the model until 2 April 2026. === MiMo-V2-Omni === Alongside MiMo-V2-Pro, Xiaomi launched MiMo-V2-Omni on 18 March 2026. It handles image, video, audio, and text inputs. Before the official release, it was codenamed "Healer Alpha" in OpenRouter. === MiMo-V2-TTS === On the same date as the release of MiMo-V2-Pro and MiMo-V2-Omni, a Text-to-Speech model named MiMo-V2-TTS was released also. It is a speech synthesis model. It was trained on audio data, which makes it capable of emotional transitions, mid-sentence tone shifts, singing, and synthesis of regional dialects like Sichuan, Cantonese, Henan, and Taiwanese. == Licensing == Xiaomi has used different licensing approaches for different models in the MiMo family. The MiMo-7B series and MiMo-V2-Flash were released as open-weight models. MiMo-V2-Flash was published under the MIT license with model weights and inference code available on Hugging Face. MiMo-V2-Pro and MiMo-V2-Omni were released as proprietary models. It was accessible through Xiaomi's API platform and third-party API providers. Luo Fuli stated that Xiaomi intended to open-source a variant of MiMo-V2-Pro. Although, she did not specify any timeline. MiMo-V2-TTS was released as a proprietary model with no publicly available weights.
IRCF360
Infrared Control Freak 360 (IRCF360) is a 360-degree proximity sensor and a motion sensing devices, developed by ROBOTmaker. The sensor is in BETA developers release as a low cost (software configurable) sensor for use within research, technical and hobby projects. == Overview == The 360-degree sensor was originally designed as a short range micro robot proximity sensor and mainly intended for Swarm robotics, Ant robotics, Swarm intelligence, autonomous Qaudcopter, Drone, UAV, multi-robot simulations e.g. Jasmine Project where 360 proximity sensing is required to avoid collision with other robots and for simple IR inter-robot communications. To overcome certain limitation with Infra-red (IR) proximity sensing (e.g. detection of dark surfaces) the sensing module includes ambient light sensing and basic tactile sensing functionality during forward movement sensing/probing providing photovore and photophobe robot swarm behaviours and characteristics. A project named Sensorium Project was started aimed at broadening the Sensors audience beyond its typical robot sensor usage. To demonstrate the sensor's functionality, opensource Java based Integrated Development Environments (IDE) are used, such as Arduino and Processing (programming language).