Ziad Obermeyer (Arabic: زياد أوبرماير) is a Lebanese American physician and researcher whose work focuses on machine learning, health policy, and clinical decision-making in medicine. He is the Blue Cross of California Distinguished Associate Professor at the UC Berkeley School of Public Health, a Chan Zuckerberg Biohub investigator, and a research associate at the National Bureau of Economic Research. He is known for his research on racial bias in health care algorithms and the use of artificial intelligence in health care. == Early life and education == Obermeyer was born in Beirut, Lebanon, and raised in Cambridge, Massachusetts. He earned a Bachelor of Arts degree from Harvard College and a Master of Philosophy (M.Phil.) in History and Science from the University of Cambridge. He received his Doctor of Medicine (M.D.) from Harvard Medical School in 2008. Before pursuing medicine, Obermeyer worked as a consultant at McKinsey & Company, advising pharmaceutical and global health clients in New Jersey, Geneva, and Tokyo. After completing his medical degree, he trained as an emergency physician at Mass General Brigham (MGB) in Boston, Massachusetts. He later continued practicing emergency medicine at the Fort Defiance Indian Hospital on the Navajo Nation in Arizona. == Academic career == Obermeyer served as an Assistant Professor at Harvard Medical School from 2014 to 2020. In 2020, he joined the University of California, Berkeley as an Associate Professor and the Blue Cross of California Distinguished Professor at the School of Public Health. == Research focus == === Algorithmic racial bias in healthcare === In 2019, Obermeyer and economist Sendhil Mullainathan examined a commercial healthcare algorithm by UnitedHealth Group, used in hospitals and by insurers to identify patients with complex health needs. The study found that the algorithm underestimated the health needs of Black patients compared to white patients with similar conditions and that reformulating it would reduce racial bias. In 2020, Obermeyer analyzed an algorithm used to allocate CARE Act relief funding to hospitals. The study identified allocation patterns that favored hospitals with higher revenues over hospitals serving larger numbers of COVID-19 patients who are predominantly Black. === Clinical decision-making === In 2021, Obermeyer and colleagues examined physician decision-making in cardiac care using machine learning models. The study found that physicians misdiagnose cases when they rely on symptoms representative of a heart attack, such as chest pain, over other symptoms. === Pain assessment === Obermeyer developed a deep learning approach to investigate the severity of osteoarthritis in underserved communities. == Policy and regulatory work == Following the publication of the 2019 algorithmic racial bias study, the New York Department of Financial Services and Department of Health launched an investigation into UnitedHealth Group's algorithm, requesting that the company cease using it, citing discriminatory business practices. Also related to this study, in December 2019, Democratic Senators Cory Booker and Ron Wyden released letters to the Federal Trade Commission and Centers for Medicare and Medicaid Services asking to investigate potential discrimination in decision-making algorithms against marginalized communities in healthcare. The senators also wrote to major healthcare companies, including Aetna and Blue Cross Blue Shield, about their internal safeguards against racial bias in their technology. In 2021, Obermeyer and colleagues at the University of Chicago Booth School of Business released the Algorithmic Bias Playbook, a resource for policymakers and technical teams working in healthcare on how to measure and mitigate algorithmic racial bias. Obermeyer testified before the U.S. Senate Financial Committee in February 2024 on artificial intelligence in healthcare, recommending transparency requirements for AI developers and independent algorithm evaluations. In December 2025, he testified before the United States House Committee on Oversight and Government Reform on the role of AI in affordable healthcare and the impact of its integration on the workforce. == Organizations == In 2021, Obermeyer cofounded Nightingale Open Science, a non-profit that creates new medical imaging datasets available for research, and Dandelion Health, a health data analytics company. In June 2023, the company launched a program to audit and evaluate the performance of algorithms to identify potential racial, ethnic, and geographic bias, funded by the Gordon and Betty Moore Foundation and the SCAN Foundation. Dandelion Health partnered with the American Heart Association in 2025 to power an AI assessment lab for cardiovascular algorithms. Obermeyer is a founding faculty member of the University of California, Berkeley–University of California, San Francisco joint program in computational precision health. == Recognition == TIME magazine named Obermeyer one of the 100 most influential people in artificial intelligence in 2023. He has served as a Chan Zuckerberg Biohub Investigator since 2022, and as a Research Associate at the National Bureau of Economic Research since 2023. He was designated an Emerging Leader by the National Academy of Medicine in 2020. Obermeyer's racial bias study received the Willard G. Manning Memorial Award for the Best Research in Health Econometrics from the American Society of Health Economists (ASHEcon) in 2021 and the Responsible Business Education Award from the Financial Times in 2022.
Breakup Notifier
Breakup Notifier was a web application written by product developer and programmer Dan Loewenherz that enabled its registered users to track the relationship status of their Facebook friends. An email notification was sent to the user when one of their Facebook friends changed their relationship status. The app was one of the most viral Facebook app's at the time of its release. It was mentioned in a skit on The Jay Leno Show and news of its popularity was published in Time magazine, The New York Post, CNET, and The Globe and Mail. == Popularity and Facebook controversy == Breakup Notifier gathered 100,000 users in less than 24 hours of its launch and reached a user base of more than 3,000,000 in February 2011. Facebook then blocked the app. Loewenherz later created an app named Crush Notifier, which differs from the original app in that users can check if they have a mutual crush. Breakup Notifier was later unblocked by Facebook and monetized.
Continuous Function Chart
A Continuous Function Chart (CFC) is a graphic editor that can be used in conjunction with the STEP 7 software package or with other tools, such as CODESYS. It is used to create the entire software structure of the CPU from ready-made blocks. When working with the editor, you place blocks on function charts, assign parameters to them, and interconnect them. Interconnecting means, for example, that values are transferred from one output to one or more inputs during communication between the blocks. Continuous function charts are basically used for controlling continuous processes, where all the logic is executed and outputs are calculated in each PLC scan. Whereas in SFC, execution will be sequential as done is batch processes.
Plotting algorithms for the Mandelbrot set
There are many programs and algorithms used to plot the Mandelbrot set and other fractals, some of which are described in fractal-generating software. These programs use a variety of algorithms to determine the color of individual pixels efficiently. == Escape time algorithm == The simplest algorithm for generating a representation of the Mandelbrot set is known as the "escape time" algorithm. A repeating calculation is performed for each x, y point in the plot area and based on the behavior of that calculation, a color is chosen for that pixel. === Unoptimized naïve escape time algorithm === In both the unoptimized and optimized escape time algorithms, the x and y locations of each point are used as starting values in a repeating, or iterating calculation (described in detail below). The result of each iteration is used as the starting values for the next. The values are checked during each iteration to see whether they have reached a critical "escape" condition, or "bailout". If that condition is reached, the calculation is stopped, the pixel is drawn, and the next x, y point is examined. For some starting values, escape occurs quickly, after only a small number of iterations. For starting values very close to but not in the set, it may take hundreds or thousands of iterations to escape. For values within the Mandelbrot set, escape will never occur. The programmer or user must choose how many iterations–or how much "depth"–they wish to examine. The higher the maximal number of iterations, the more detail and subtlety emerge in the final image, but the longer time it will take to calculate the fractal image. Escape conditions can be simple or complex. Because no complex number with a real or imaginary part greater than 2 can be part of the set, a common bailout is to escape when either coefficient exceeds 2. A more computationally complex method that detects escapes sooner, is to compute distance from the origin using the Pythagorean theorem, i.e., to determine the absolute value, or modulus, of the complex number. If this value exceeds 2, or equivalently, when the sum of the squares of the real and imaginary parts exceed 4, the point has reached escape. More computationally intensive rendering variations include the Buddhabrot method, which finds escaping points and plots their iterated coordinates. The color of each point represents how quickly the values reached the escape point. Often black is used to show values that fail to escape before the iteration limit, and gradually brighter colors are used for points that escape. This gives a visual representation of how many cycles were required before reaching the escape condition. To render such an image, the region of the complex plane we are considering is subdivided into a certain number of pixels. To color any such pixel, let c {\displaystyle c} be the midpoint of that pixel. We now iterate the critical point 0 under P c {\displaystyle P_{c}} , checking at each step whether the orbit point has modulus larger than 2. When this is the case, we know that c {\displaystyle c} does not belong to the Mandelbrot set, and we color our pixel according to the number of iterations used to find out. Otherwise, we keep iterating up to a fixed number of steps, after which we decide that our parameter is "probably" in the Mandelbrot set, or at least very close to it, and color the pixel black. In pseudocode, this algorithm would look as follows. The algorithm does not use complex numbers and manually simulates complex-number operations using two real numbers, for those who do not have a complex data type. The program may be simplified if the programming language includes complex-data-type operations. for each pixel (Px, Py) on the screen do x0 := scaled x coordinate of pixel (scaled to lie in the Mandelbrot X scale (-2.00, 0.47)) y0 := scaled y coordinate of pixel (scaled to lie in the Mandelbrot Y scale (-1.12, 1.12)) x := 0.0 y := 0.0 iteration := 0 max_iteration := 1000 while (xx + yy ≤ 22 AND iteration < max_iteration) do xtemp := xx - yy + x0 y := 2xy + y0 x := xtemp iteration := iteration + 1 color := palette[iteration] plot(Px, Py, color) Here, relating the pseudocode to c {\displaystyle c} , z {\displaystyle z} and P c {\displaystyle P_{c}} : z = x + i y {\displaystyle z=x+iy\ } z 2 = x 2 + 2 i x y {\displaystyle z^{2}=x^{2}+2ixy} - y 2 {\displaystyle y^{2}\ } c = x 0 + i y 0 {\displaystyle c=x_{0}+iy_{0}\ } and so, as can be seen in the pseudocode in the computation of x and y: x = R e ( z 2 + c ) = x 2 − y 2 + x 0 {\displaystyle x=\mathop {\mathrm {Re} } (z^{2}+c)=x^{2}-y^{2}+x_{0}} and y = I m ( z 2 + c ) = 2 x y + y 0 . {\displaystyle y=\mathop {\mathrm {Im} } (z^{2}+c)=2xy+y_{0}.\ } To get colorful images of the set, the assignment of a color to each value of the number of executed iterations can be made using one of a variety of functions (linear, exponential, etc.). One practical way, without slowing down calculations, is to use the number of executed iterations as an entry to a palette initialized at startup. If the color table has, for instance, 500 entries, then the color selection is n mod 500, where n is the number of iterations. === Optimized escape time algorithms === The code in the previous section uses an unoptimized inner while loop for clarity. In the unoptimized version, one must perform five multiplications per iteration. To reduce the number of multiplications the following code for the inner while loop may be used instead: x2:= 0 y2:= 0 w:= 0 while (x2 + y2 ≤ 4 and iteration < max_iteration) do x:= x2 - y2 + x0 y:= w - x2 - y2 + y0 x2:= x x y2:= y y w:= (x + y) (x + y) iteration:= iteration + 1 The above code works via some algebraic simplification of the complex multiplication: ( i y + x ) 2 = − y 2 + 2 i y x + x 2 = x 2 − y 2 + 2 i y x {\displaystyle {\begin{aligned}(iy+x)^{2}&=-y^{2}+2iyx+x^{2}\\&=x^{2}-y^{2}+2iyx\end{aligned}}} Using the above identity, the number of multiplications can be reduced to three instead of five. The above inner while loop can be further optimized by expanding w to w = x 2 + 2 x y + y 2 {\displaystyle w=x^{2}+2xy+y^{2}} Substituting w into y = w − x 2 − y 2 + y 0 {\displaystyle y=w-x^{2}-y^{2}+y_{0}} yields y = 2 x y + y 0 {\displaystyle y=2xy+y_{0}} and hence calculating w is no longer needed. The further optimized pseudocode for the above is: x:= 0 y:= 0 x2:= 0 y2:= 0 while (x2 + y2 ≤ 4 and iteration < max_iteration) do x2:= x x y2:= y y y:= 2 x y + y0 x:= x2 - y2 + x0 iteration:= iteration + 1 Note that in the above pseudocode, 2 x y {\displaystyle 2xy} seems to increase the number of multiplications by 1, but since 2 is the multiplier the code can be optimized via ( x + x ) y {\displaystyle (x+x)y} . == Coloring algorithms == In addition to plotting the set, a variety of algorithms have been developed to efficiently color the set in an aesthetically pleasing way show structures of the data (scientific visualisation) === Histogram coloring === A more complex coloring method involves using a histogram which pairs each pixel with said pixel's maximum iteration count before escape/bailout. This method will equally distribute colors to the same overall area, and, importantly, is independent of the maximum number of iterations chosen. This algorithm has four passes. The first pass involves calculating the iteration counts associated with each pixel (but without any pixels being plotted). These are stored in an array IterationCounts[x][y], where x and y are the x and y coordinates of said pixel on the screen respectively. The first step of the second pass is to create an array NumIterationsPerPixel[n], where the array size n is the maximum iteration count. Next, one must iterate over the array of pixel-iteration count pairs IterationCounts[x][y], and retrieve each pixel's saved iteration count, i, via e.g. i = IterationCounts[x][y]. After each pixel's iteration count i is retrieved, it is necessary to index the NumIterationsPerPixel array at i and increment the indexed value (which is initially zero) -- e.g. NumIterationsPerPixel[i] = NumIterationsPerPixel[i] + 1. for (x = 0; x < width; x++) do for (y = 0; y < height; y++) do i:= IterationCounts[x][y] NumIterationsPerPixel[i]++ The third pass iterates through the NumIterationsPerPixel array and adds up all the stored values, saving them in total. The array index represents the number of pixels that reached that iteration count before bailout. total: = 0 for (i = 0; i < max_iterations; i++) do total += NumIterationsPerPixel[i] After this, the fourth pass begins and all the values in the IterationCounts array are indexed, and, for each iteration count i, associated with each pixel, the count is added to a global sum of all the iteration counts from 1 to i in the NumIterationsPerPixel array . This value is then normalized by dividing the sum by the total value computed earlier. hue[][]:= 0.0 for (x = 0; x < width; x++) do for (y = 0; y < height; y++) do iteration:= Iteration
Bin picking
Bin picking (also referred to as random bin picking) is a core problem in computer vision and robotics. The goal is to have a robot with sensors and cameras attached to it pick-up known objects with random poses out of a bin using a suction gripper, parallel gripper, or other kind of robot end effector. Early work on bin picking made use of Photometric Stereo in recovering the shapes of objects and to determine their orientation in space. Amazon previously held a competition focused on bin picking referred to as the "Amazon Picking Challenge", which was held from 2015 to 2017. The challenge tasked entrants with building their own robot hardware and software that could attempt simplified versions of the general task of picking and stowing items on shelves. The robots were scored by how many items were picked and stowed in a fixed amount of time. The first Amazon Robotics challenge was won by a team from TU Berlin in 2015, followed by a team from TU Delft and the Dutch company "Fizyr" in 2016. The last Amazon Robotics Challenge was won by the Australian Centre for Robotic Vision at Queensland University of Technology with their robot named Cartman. The Amazon Robotics/Picking Challenge was discontinued following the 2017 competition. Although there can be some overlap, bin picking is distinct from "each picking" and the bin packing problem.
Wetware computer
A wetware computer is an organic computer (which can also be known as an artificial organic brain or a neurocomputer) composed of organic material "wetware" such as "living" neurons. Wetware computers composed of neurons are different than conventional computers because they use biological materials, and offer the possibility of substantially more energy-efficient computing. While a wetware computer is still largely conceptual, there has been limited success with construction and prototyping, which has acted as a proof of the concept's realistic application to computing in the future. The most notable prototypes have stemmed from the research completed by biological engineer William Ditto during his time at the Georgia Institute of Technology. His work constructing a simple neurocomputer capable of basic addition from leech neurons in 1999 was a significant discovery for the concept. This research was a primary example driving interest in creating these artificially constructed, but still organic brains. == Origins and theoretical foundations == The term wetware came from cyberpunk fiction, notably through Gibson's Neuromancer, but was quickly taken up in scientific literature to explain computation by biological material. Theories of early biological computation borrowed from Alan Turing's morphogenesis model, which showed that chemical interactions could produce complex patterns without centralized control. Hopfield's associative memory networks also provided a foundation for biological information systems with fault tolerance and self-organization. == Major characteristics and processes == Biological wetware systems demonstrate dynamic reconfigurability underpinned by neuroplasticity and enable continuous learning and adaptation. Reaction-diffusion-based computing and molecular logic gates allow spatially parallel information processing unachievable in conventional systems. These systems also show fault tolerance and self-repair at the cellular and network level. The development of cerebral organoids—miniature lab-grown brains—demonstrates spontaneous learning behavior and suggests biological tissue as a viable computational substrate. == Overview == The concept of wetware is an application of specific interest to the field of computer manufacturing. Moore's law, which states that the number of transistors which can be placed on a silicon chip is doubled roughly every two years, has acted as a goal for the industry for decades, but as the size of computers continues to decrease, the ability to meet this goal has become more difficult, threatening to reach a plateau. Due to the difficulty in reducing the size of computers because of size limitations of transistors and integrated circuits, wetware provides an unconventional alternative. A wetware computer composed of neurons is an ideal concept because, unlike conventional materials which operate in binary (on/off), a neuron can shift between thousands of states, constantly altering its chemical conformation, and redirecting electrical pulses through over 200,000 channels in any of its many synaptic connections. Because of this large difference in the possible settings for any one neuron, compared to the binary limitations of conventional computers, the space limitations are far fewer. == Background == The concept of wetware is distinct and unconventional and draws slight resonance with both hardware and software from conventional computers. While hardware is understood as the physical architecture of traditional computational devices, comprising integrated circuits and supporting infrastructure, software represents the encoded architecture of storage and instructions. Wetware is a separate concept that uses the formation of organic molecules, mostly complex cellular structures (such as neurons), to create a computational device such as a computer. In wetware, the ideas of hardware and software are intertwined and interdependent. The molecular and chemical composition of the organic or biological structure would represent not only the physical structure of the wetware but also the software, being continually reprogrammed by the discrete shifts in electrical pulses and chemical concentration gradients as the molecules change their structures to communicate signals. The responsiveness of a cell, proteins, and molecules to changing conformations, both within their structures and around them, ties the idea of internal programming and external structure together in a way that is alien to the current model of conventional computer architecture. The structure of wetware represents a model where the external structure and internal programming are interdependent and unified; meaning that changes to the programming or internal communication between molecules of the device would represent a physical change in the structure. The dynamic nature of wetware borrows from the function of complex cellular structures in biological organisms. The combination of "hardware" and "software" into one dynamic, and interdependent system which uses organic molecules and complexes to create an unconventional model for computational devices is a specific example of applied biorobotics. === The cell as a model of wetware === Cells in many ways can be seen as their form of naturally occurring wetware, similar to the concept that the human brain is the preexisting model system for complex wetware. In his book Wetware: A Computer in Every Living Cell (2009) Dennis Bray explains his theory that cells, which are the most basic form of life, are just a highly complex computational structure, like a computer. To simplify one of his arguments a cell can be seen as a type of computer, using its structured architecture. In this architecture, much like a traditional computer, many smaller components operate in tandem to receive input, process the information, and compute an output. In an overly simplified, non-technical analysis, cellular function can be broken into the following components: Information and instructions for execution are stored as DNA in the cell, RNA acts as a source for distinctly encoded input, processed by ribosomes and other transcription factors to access and process the DNA and to output a protein. Bray's argument in favor of viewing cells and cellular structures as models of natural computational devices is important when considering the more applied theories of wetware to biorobotics. === Biorobotics === Wetware and biorobotics are closely related concepts, which both borrow from similar overall principles. A biorobotic structure can be defined as a system modeled from a preexisting organic complex or model such as cells (neurons) or more complex structures like organs (brain) or whole organisms. Unlike wetware, the concept of biorobotics is not always a system composed of organic molecules, but instead could be composed of conventional material which is designed and assembled in a structure similar or derived from a biological model. Biorobotics have many applications and are used to address the challenges of conventional computer architecture. Conceptually, designing a program, robot, or computational device after a preexisting biological model such as a cell, or even a whole organism, provides the engineer or programmer the benefits of incorporating into the structure the evolutionary advantages of the model. == Effects on users == Wetware technologies such as BCIs and neuromorphic chips offer new possibilities for user autonomy. For those with disabilities, such systems could restore motor or sensory functions and enhance quality of life. However, these technologies raise ethical questions: cognitive privacy, consent over biological data, and risk of exploitation. Without proper oversight, wetware technologies may also widen inequality, favoring those with access to cognitive enhancements. Open governance frameworks and ethical AI design grounded in neuro ethics will be essential. With the development of wetware devices, disparities in access could exacerbate social inequalities, benefiting those who have resources to enhance cognitive or physical abilities. It is necessary to create strong ethical frameworks, inclusive development practices, and open systems of governance to reduce risks and make sure that wetware advances are beneficial to all segments of society. == Applications and goals == === Basic neurocomputer composed of leech neurons === In 1999 William Ditto and his team of researchers at Georgia Institute of Technology and Emory University created a basic form of a wetware computer capable of simple addition by harnessing leech neurons. Leeches were used as a model organism due to the large size of their neuron, and the ease associated with their collection and manipulation. However, these results have never been published in a peer-reviewed journal, prompting questions about the validity of the claims. The computer was able to complete basic addition through electrical probes
Memory color effect
The memory color effect is the phenomenon that the canonical hue of a type of object acquired through experience (e.g. the sky, a leaf, or a strawberry) can directly modulate the appearance of the actual colors of objects. Human observers acquire memory colors through their experiences with instances of that type. For example, most human observers know that an apple typically has a reddish hue; this knowledge about the canonical color which is represented in memory constitutes a memory color. As an example of the effect, normal human trichromats, when presented with a gray banana, often perceive the gray banana as being yellow - the banana's memory color. In light of this, subjects typically adjust the color of the banana towards the color blue - the opponent color of yellow - when asked to adjust its surface to gray to cancel the subtle activation of banana's memory color. Subsequent empirical studies have also shown the memory color effect on man-made objects (e.g. smurfs, German mailboxes), the effect being especially pronounced for blue and yellow objects. To explain this, researchers have argued that because natural daylight shifts from short wavelengths of light (i.e., bluish hues) towards light of longer wavelengths (i.e., yellowish-orange hues) during the day, the memory colors for blue and yellow objects are recruited by the visual system to a higher degree to compensate for this fluctuation in illumination, thereby providing a stronger memory color effect. == Form identification == Memory color plays a role when detecting an object. In a study where participants were given objects, such as an apple, with two alternate forms for each, a crooked apple and a circular apple, researchers changed the colors of the alternate forms and asked if they could identify them. Most of the participants answered "unsure," suggesting that we use memory color when identifying an object. The research redefined memory color as a phenomenon when "a form's identity affects the phenomenal hue of that form." == Color effect on memorization == Memory color effect can be derived from the human instinct to memorize objects better. Comparing the effect of recognizing gray-scaled images and colored images, results showed that people were able to recall colored images 5% higher compared to gray-scaled images. An important factor was that higher level of contrast between the object and background color influences memory. In a specific study related to this, participants reported that colors were 5% to 10% easier to recognize compared to black and white. == Color constancy and memory color effect == Color constancy is the phenomenon where a surface to appear to be of the same color under a wide rage of illumination. A study tested two hypotheses with regards to color memory; the photoreceptor hypothesis and the surface reflectance hypothesis. The test color was surround either by various color patches forming a complex pattern or a uniform “grey” field at the same chromaticity as that of the illuminant. The test color was presented on a dark background for the control group. It was observed that complex surround results where in line with the surface-reflectance hypothesis and not the photoreceptor hypothesis, showing that the accuracy and precision of color memory are fundamentals to understanding the phenomenon of color constancy. == Significance to the evolution of trichromacy == While objects that possess canonical hues make up a small percentage of the objects which populate humans’ visual experience, the human visual system evolved in an environment populated with objects that possess canonical hues. This suggests that the memory color effect is related to the emergence of trichromacy because it has been argued that trichromacy evolved to optimize the ability to detect ripe fruits—objects that appear in canonical hues. == In perception research == In perception research, the memory color effect is cited as evidence for the opponent color theory, which states that four basic colors can be paired with its opponent color: red—green, blue—yellow. This explains why participants adjust the ripe banana color to a blueish tone to make its memory color yellow as gray. Researchers have also found empirical evidence that suggests memory color is recruited by the visual system to achieve color constancy. For example, participants had a lower percentage of color constancy when looking at a color incongruent scene, such as a purple banana, compared to a color diagnostical scene, a yellow banana. This suggests that color constancy is influenced by the color of objects that we are familiar with, which the memory color effect takes part.