Biohybrid systems refer to the integration of biological materials, such as cells or tissues, with artificial components, including electronics or mechanical structure. This combination incorporates the capabilities of living organisms with the precision of man-made technology. As a result, these systems perform tasks that neither biology nor machines could achieve independently. Biohybrid systems might use lab-cultured muscle cells to power small robots or combine sensors with living tissue for better health sensing. The intent behind these systems is to combine the benefits of biological and technological components to introduce new solutions for complex medical challenges. Biohybrid systems may have transformative potential across sectors, such as robotics to create actuators and sensors that mimic natural muscle and nerve function, medicine in developing smart implants and drug delivery systems, in prosthetics for enhancing user control through neural or muscular interfaces and environmental sustainability for deploying biohybrid solutions for pollution sensing or remediation. == Origin == The term "biohybrid" is a compound of "bio" from biology (meaning life) and "hybrid" (referring to a combination of distinct elements), denoting a field of study. Its use helps distinguish such systems from purely biological constructs or entirely synthetic machines. Early academic mentions may include bio actuated robotics papers and foundational tissue-robot integration studies published in journals like Nature Biotechnology or Science Robotics. The emergence of the term reflects a growing recognition of the need to describe systems that do not fit cleanly into traditional categories. == Design principles == One of the most significant biohybrid challenges is to engineer interfaces between living tissue and artificial materials that are efficient. This means having precise control over adhesion at the surface, diffusion of nutrients, and signal conduction. Actuation mechanisms within the heart of these systems generate movement or mechanical response. These may be in the form of living muscle cells such as skeletal myocytes or cardiomyocytes, soft pneumatic actuators, or electrical stimulation-responsive tissues. Materials selection is equally critical. Hydrogels, elastomers like PDMS (polydimethylsiloxane), and biopolymers are commonly used due to their softness and biocompatibility. These materials must support cell viability, resist immune attack, and allow the integration of mechanical or electrical components. == Key components == At their core, biohybrid systems work by bridging living biological parts with technology. Through this integration, functionality that neither system could accomplish singularly is possible. Biological parts may be cells, tissues, or even organs—occasionally cultured in a laboratory setting. These biological parts carry out biologically inspired behaviors, such as muscle contraction or chemical sensing in the body. Technological components may constitute devices like sensors, electronic components, and mechanical structure. These manipulate the system, supply power, or transfer data. An example is a sensor that is implantable within a body and detects glucose levels as it sends information to a smart phone. By integrating these artificial and biological parts, biohybrid systems can perform advanced functions, such as tissue regeneration, real-time health monitoring, or the recovery of motor function in paralysis patients. Biohybrid systems generally consist of two major components: the biological and the mechanical. Biological components may include muscle cells for contraction, endothelial cells for vascularization, and stem cells for regenerative capabilities. Mechanical components comprise soft actuators that mimic organic motion, synthetic scaffolds that provide support and structure, and microfluidic systems that facilitate the delivery of nutrients and removal of waste. These components are combined in a manner that allows for dynamic, lifelike behavior—such as the contraction of tissue or the propagation of mechanical waves—while maintaining biocompatibility and durability. == Applications == The range of applications for biohybrid systems is broad and continuously expanding. In robotics, biohybrid structures have been used to engineer microscopic, muscle-driven machines, such as Harvard University's biohybrid stingray robot. In medical applications, they offer new alternatives for organ repair and augmentation, including biohybrid heart valves and esophageal scaffolds. Biohybrids are also promising in neural interfaces, where the goal is to create long-lasting, stable interaction between mechanical devices and brain tissue. Muscle-actuated drug response platforms are under exploration in pharmacology for modelling and real-time screening. == Examples == Several high-profile research projects have demonstrated the potential of biohybrid systems: Harvard researchers developed a biohybrid swimming ray powered by rat cardiac cells layered onto a gold skeleton, mimicking the motion of a real stingray. At the Massachusetts Institute of Technology, a cardiac pump actuated entirely by living heart muscle cells was engineered to simulate the behavior of a beating heart. Bio actuated soft robots have been built to simulate gut peristalsis, using muscle contractions to replicate natural wave-like movement in the digestive tract. == Challenges and limitations == As with many technologies that involve living systems, biohybrid systems raise important ethical and biomedical questions. Cell sourcing remains a key issue, particularly when embryonic or animal-derived cells are used. Long-term viability is another concern—living tissues must be kept alive with nutrients and oxygen, and they often degrade or elicit immune responses when implanted. Powering these biological parts presents logistical and ethical hurdles as well. Systems must either include internal mechanisms for nutrient delivery or be supported externally, which can limit portability and independence. == Future directions == Researchers are exploring self-directed, self-regulated organ substitutes and regenerative implants that can respond to their surroundings in real-time. These systems may be integrated with artificial intelligence to make them adjust to stimuli and coordinate complex behaviors. Future potential applications are wearable biohybrid systems for rehabilitation, space medicine devices for long-duration missions, and implantable devices that integrate into human physiology.
Cloud-native computing
Cloud native computing is an approach in software development that utilizes cloud computing to "build and run scalable applications in modern, dynamic environments such as public, private, and hybrid clouds". These technologies, such as containers, microservices, serverless functions, cloud native processors and immutable infrastructure, deployed via declarative code are common elements of this architectural style. Cloud native technologies focus on minimizing users' operational burden. Cloud native techniques "enable loosely coupled systems that are resilient, manageable, and observable. Combined with robust automation, they allow engineers to make high-impact changes frequently and predictably with minimal toil." This independence contributes to the overall resilience of the system, as issues in one area do not necessarily cripple the entire application. Additionally, such systems are easier to manage, and monitor, given their modular nature, which simplifies tracking performance and identifying issues. Frequently, cloud-native applications are built as a set of microservices that run in Open Container Initiative compliant containers, such as Containerd, and may be orchestrated in Kubernetes and managed and deployed using DevOps and Git CI workflows (although there is a large amount of competing open source that supports cloud-native development). The advantage of using containers is the ability to package all software needed to execute into one executable package. The container runs in a virtualized environment, which isolates the contained application from its environment.
Clapper (service)
Clapper is an American short-form video-hosting service headquartered in Dallas, Texas. It was founded in 2020 by Edison Chen as an alternative for TikTok for mature audiences. The app is functionally similar to TikTok and includes tipping and e-commerce features. Following an influx of far-right content in early 2021, Clapper strengthened its moderation practices. It achieved 2 million monthly active users by 2023, and the number of downloads increased after a U.S. bill that would potentially ban TikTok in the country was signed in 2024. == History == With its offices in Dallas, Texas, Clapper was founded in July 2020 by Chinese-American entrepreneur Edison Chen. Chen considered that most online platforms, such as TikTok, were being targeted to young generations, such as Generation Z. He then concepted Clapper as a service with short-form content for mature audiences among Generation X and millennials, while not intending to compete directly with TikTok. Clapper averaged fewer than ten thousand daily active users during 2020, reaching 500 thousand downloads in the next year. Initially without paying for external advertising, the company raised about $3 million during a 2021 seed funding round. In 2023, the app reportedly reached about 300 to 400 thousand daily active users and 2 million monthly active users. The average user was between the ages of 35 and 55. Following the April 2024 signing of the Protecting Americans from Foreign Adversary Controlled Applications Act, which would potentially enact a ban on TikTok in the U.S. in January 2025, Clapper averaged 200 thousand weekly downloads. In 2025, before the day scheduled for the ban (January 19), TikTok users migrated to other apps. As a result, Clapper received 1.4 million new downloads in a week preceding the date. It was listed as the third most-downloaded free app on Apple's App Store on January 14, behind Xiaohongshu and Lemon8, and the term "TikTok refugee" became a trending term. == Features == Clapper presents similarities with TikTok in its layout, including "Following" and "For You" tabs with videos up to three minutes long that can be liked, commented on or shared. A "Clapback" feature allows users to create responses to videos from others. Users can create livestreams and chat rooms in the app. Users can tip Clapper creators through its Clapper Fam monetization feature, in place of in-app advertisements. The Clapper Shop allows for e-commerce between users. The service had distributed $10 million to its users in total by 2023, according to Clapper CEO Chen. == Content == Clapper includes a policy requiring users to be at least 17 years of age, although Clapper CEO Chen described that "there is no adult content" on the platform. Lindsay Dodgson of Business Insider described the content as generally outdated and "reminiscent of 'getting owned' compilations of the earlier internet." The Washington Post's Tatum Hunter characterized Clapper as including sexual or engagement baiting content more prevalently than TikTok. === Moderation === Clapper's team, which had fifteen employees in early 2021, initially stated it would not moderate content as strictly as TikTok and would mostly rely on user reports. Following that year's January 6 United States Capitol attack, far-right conservative videos promoting QAnon and anti-vaccine conspiracy theories appeared on Clapper's "For You" page to a substantial degree for weeks. The videos were made in protest against decisions by platforms, particularly TikTok, to ban such content. Clapper's team stated in January 10 that its rules prohibiting incitements to violence would be strictly enforced. By February, videos and accounts promoting the conspiracy theories had been removed, and QAnon-related content was banned permanently. Clapper's team hired more content auditors and implemented moderation by artificial intelligence for further community guideline violations.
List of speech recognition software
Speech recognition software is available for many computing platforms, operating systems, use models, and software licenses. Here is a listing of such, grouped in various useful ways. == Acoustic models and speech corpus (compilation) == The following list presents notable speech recognition software engines with a brief synopsis of characteristics. == Macintosh == == Cross-platform web apps based on Chrome == The following list presents notable speech recognition software that operate in a Chrome browser as web apps. They make use of HTML5 Web-Speech-API. == Mobile devices and smartphones == Many mobile phone handsets, including feature phones and smartphones such as iPhones and BlackBerrys, have basic dial-by-voice features built in. Many third-party apps have implemented natural-language speech recognition support, including: == Windows == === Windows built-in speech recognition === The Windows Speech Recognition version 8.0 by Microsoft comes built into Windows Vista, Windows 7, Windows 8 and Windows 10. Speech Recognition is available only in English, French, Spanish, German, Japanese, Simplified Chinese, and Traditional Chinese and only in the corresponding version of Windows; meaning you cannot use the speech recognition engine in one language if you use a version of Windows in another language. Windows 7 Ultimate and Windows 8 Pro allow you to change the system language, and therefore change which speech engine is available. Windows Speech Recognition evolved into Cortana (software), a personal assistant included in Windows 10. === Windows 7, 8, 10, 11 third-party speech recognition === Braina – Dictate into third party software and websites, fill web forms and execute vocal commands. Dragon NaturallySpeaking from Nuance Communications – Successor to the older DragonDictate product. Focus on dictation. 64-bit Windows support since version 10.1. Tazti – Create speech command profiles to play PC games and control applications – programs. Create speech commands to open files, folders, webpages, applications. Windows 7, Windows 8 and Windows 8.1 versions. Voice Finger – software that improves the Windows speech recognition system by adding several extensions to it. The software enables controlling the mouse and the keyboard by only using the voice. It is especially useful for aiding users to overcome disabilities or to heal from computer injuries. === Microsoft Speech API === The first version of the Microsoft Speech API was released for Windows NT 3.51 and Windows 95 in 1995, it was then part of Windows up to Windows Vista. This initial version already contained Direct Speech Recognition and Direct Text To Speech APIs which applications could use to directly control engines, as well as simplified 'higher-level' Voice Command and Voice Talk APIs. Speech recognition functionality included as part of Microsoft Office and on Tablet PCs running Microsoft Windows XP Tablet PC Edition. It can also be downloaded as part of the Speech SDK 5.1 for Windows applications, but since that is aimed at developers building speech applications, the pure SDK form lacks any user interface (numerous applications were available), and thus is unsuitable for end users. == Built-in software == Microsoft Kinect includes built-in software which allows speech recognition of commands. Older generations of Nokia phones like Nokia N Series (before using Windows 7 mobile technology) used speech-recognition with family names from contact list and a few commands. Siri, originally implemented in the iPhone 4S, Apple's personal assistant for iOS, which uses technology from Nuance Communications. Cortana (software), Microsoft's personal assistant built into Windows Phone and Windows 10. == Interactive voice response == The following are interactive voice response (IVR) systems: CSLU Toolkit Genesys HTK – copyrighted by Microsoft, but allows altering software for licensee's internal use LumenVox ASR Tellme Networks; acquired by Microsoft == Unix-like x86 and x86-64 speech transcription software == Janus Recognition Toolkit (JRTk) Mozilla DeepSpeech was developing an open-source Speech-To-Text engine based on Baidu's deep speech research paper. Weesper Neon Flow – professional voice-dictation software that provides offline speech-to-text processing on macOS and Windows using local AI models. It is not open source and offers a paid subscription after a 15‑day free trial. Vocalinux – open-source speech transcription software for Linux. == Discontinued software == IBM VoiceType (formerly IBM Personal Dictation System) IBM ViaVoice – Embedded version still maintained by IBM. No longer supported for versions above Windows Vista. Untested above macOS 10.4 or on Macintoshes with an Intel chipset. Quack.com; acquired by AOL; the name has now been reused for an iPad search app. SpeechWorks from Nuance Communications. Yap Speech Cloud – Speech-to-text platform acquired by Amazon.com.
Pulse-coupled networks
Pulse-coupled networks or pulse-coupled neural networks (PCNNs) are neural models proposed by modeling a cat's visual cortex, and developed for high-performance biomimetic image processing. In 1989, Eckhorn introduced a neural model to emulate the mechanism of cat's visual cortex. The Eckhorn model provided a simple and effective tool for studying small mammal’s visual cortex, and was soon recognized as having significant application potential in image processing. In 1994, Johnson adapted the Eckhorn model to an image processing algorithm, calling this algorithm a pulse-coupled neural network. The basic property of the Eckhorn's linking-field model (LFM) is the coupling term. LFM is a modulation of the primary input by a biased offset factor driven by the linking input. These drive a threshold variable that decays from an initial high value. When the threshold drops below zero it is reset to a high value and the process starts over. This is different than the standard integrate-and-fire neural model, which accumulates the input until it passes an upper limit and effectively "shorts out" to cause the pulse. LFM uses this difference to sustain pulse bursts, something the standard model does not do on a single neuron level. It is valuable to understand, however, that a detailed analysis of the standard model must include a shunting term, due to the floating voltages level in the dendritic compartment(s), and in turn this causes an elegant multiple modulation effect that enables a true higher-order network (HON). A PCNN is a two-dimensional neural network. Each neuron in the network corresponds to one pixel in an input image, receiving its corresponding pixel's color information (e.g. intensity) as an external stimulus. Each neuron also connects with its neighboring neurons, receiving local stimuli from them. The external and local stimuli are combined in an internal activation system, which accumulates the stimuli until it exceeds a dynamic threshold, resulting in a pulse output. Through iterative computation, PCNN neurons produce temporal series of pulse outputs. The temporal series of pulse outputs contain information of input images and can be used for various image processing applications, such as image segmentation and feature generation. Compared with conventional image processing means, PCNNs have several significant merits, including robustness against noise, independence of geometric variations in input patterns, capability of bridging minor intensity variations in input patterns, etc. A simplified PCNN called a spiking cortical model was developed in 2009. == Applications == PCNNs are useful for image processing, as discussed in a book by Thomas Lindblad and Jason M. Kinser. PCNNs have been used in a variety of image processing applications, including: image segmentation, pattern recognition, feature generation, face extraction, motion detection, region growing, image denoising and image enhancement Multidimensional pulse image processing of chemical structure data using PCNN has been discussed by Kinser, et al. They have also been applied to an all pairs shortest path problem.
Ciscogate
Ciscogate, also known as the Black Hat Bug, is the name given to a legal incident that occurred at the Black Hat Briefings security conference in Las Vegas, Nevada, on July 27, 2005. On the morning of the first day of the conference, July 26, 2005, some attendees noticed that 30 pages of text had been physically ripped out of the extensive conference presentation booklet the night before at the request of Cisco Systems and the CD-ROM with presentation slides was not included. It was determined the pages covered a talk to be given by Michael Lynn, a security researcher with Atlanta-based IBM Internet Security Systems (ISS). Instead of the pages with the details, attendees found a photographed copy of a notice from Black Hat saying "Due to some last minute changes beyond Black Hat's control, and at the request of the presenter, the included materials aren't up to the standards Black Hat tries to meet. Black Hat will be the first to apologize. We hope the vendors involved will follow suit." According to Lynn's lawyer, his employer had approved of the talk leading up to the conference but changed their minds two days before the scheduled talk, forbidding him from presenting. Lynn's original presentation was to cover a vulnerability in Cisco routers. The presentation was one of four scheduled to follow Jeff Moss' keynote address on the first day of the conference, titled "Cisco IOS Security Architecture". After being told by his employer that he could not present on the topic, Lynn chose an alternate topic. Cisco and ISS had offered to give new joint presentation but this was turned down by Black Hat because the original speaking slot was given to Lynn, not Cisco. Lynn's presentation began by covering security issues in services that allow users to make Voice over IP telephone calls. Shortly after beginning the presentation Lynn changed back to his original topic and began disclosing some technical details of the vulnerability he found in Cisco routers stating that he would rather resign from his job at ISS than keep the details private. == Lawsuit == Shortly after Lynn concluded his talk he met Jennifer Granick, who would soon become his lawyer. During their initial meeting Lynn told Granick that he expected to be sued. Later in the evening Lynn had heard that Cisco and ISS had filed a lawsuit and requested a temporary restraining order against Black Hat but not himself. A public relations representative from Black Hat told Granick that the lawsuit was against both Black Hat and Lynn and that the companies had scheduled an Ex parte hearing in San Francisco the next morning to request the restraining order. That night, Andrew Valentine, an attorney for ISS and Cisco called Lynn who directed them to Granick. During the conversation Valentine explained the claims and accusations against Lynn, which included three things: 1) ISS claimed copyright over the presentation that Lynn gave, 2) Cisco claimed copyright over the decompiled machine code obtained from the router which was included in the presentation, and 3) Cisco claimed the presentation contained trade secrets. These complaints were outlined in a civil complaint at the U.S. Northern District of California and filed against both Lynn and Black Hat. According to Granick, she and Valentine were able agree to an injunction to settle the case without court proceedings. This deal was almost called off due to an inadvertent mistake by Black Hat in which they had restored Lynn's presentation on their web server. Black Hat, Granick, and the plaintiff's lawyers were able to resolve this problem and the deal stood. One condition of the settlement required Lynn to provide an image of all computer data he used in his research to be provided to a third party for forensic analysis before erasing his research and any Cisco data from his systems. The settlement also stipulated that Lynn was prohibited from talking about the vulnerability in the future. == FBI Investigation == Shortly after lawyers for Lynn and ISS / Cisco filed settlement papers, FBI agents from the Las Vegas office arrived at the conference to begin asking questions. According to Granick, they were there at the request of the Atlanta FBI office and Lynn was not of interest. Granick asserted the Fifth and Sixth amendment rights on behalf of her client, Lynn. Granick asserted his rights for the Atlanta office and asked if an arrest warrant had been issued for Lynn. Over the next 24 hours Granick was not able to ascertain the status of a warrant but ultimately determined no warrant was issued. When the FBI was asked about the case by a journalist, spokesman Paul Bresson declined to discuss the case saying "Our policy is to not make any comment on anything that is ongoing. That's not to confirm that something is, because I really don't know". Granick would only confirm to journalists that the "investigation has to do with the presentation". == Response == === Attendees === Attendees of Black Hat Briefings, as well as many that also attended DEF CON, were not happy with vendors threatening legal action over vulnerability disclosure. The term "Ciscogate" was coined quickly by an unknown person, but some attendees were quick to create shirts to commemorate the incident. === Cisco === Mojgan Khalili, a senior manager for corporate PR at Cisco, issued a statement to the press saying "It is important to note that the information Mr. Lynn presented was not a disclosure of a new vulnerability or a flaw with Cisco IOS software. Mr. Lynn's research explores possible ways to expand exploitations of existing security vulnerabilities impacting routers." === ISS === Kim Duffy, managing director of ISS Australia, was asked about ISS's response to the incident. Duffy responded that it was "business as usual" as the company handled the incident "strictly by the book". He gave a brief statement to ZDNet UK saying "ISS has published rules for disclosure and that is what we stick to. We didn't care to publish [the disclosure] because we were not ready. We had not completed the research to our satisfaction so it was not ready to be disclosed". ISS spokesperson Roger Fortier confirmed that Lynn was no longer employed with the company and that ISS was still working with Cisco on the matter. He gave a statement to the Washington Post saying "ISS and Cisco have been working on this in the background and didn't feel at this time that the material was ready for publication. The decision was made on Monday to pull the presentation because we wanted to make sure the research was fully baked."
Quack.com
Quack.com was an early voice portal company. The domain name later was used for Quack, an iPad search application from AOL. == History == It was founded in 1998 by Steven Woods, Jeromy Carriere and Alex Quilici as a Pittsburgh, Pennsylvania, USA, based voice portal infrastructure company named Quackware. Quack was the first company to try to create a voice portal: a consumer-based destination "site" in which consumers could not only access information by voice alone, but also complete transactions. Quackware launched a beta phone service in 1999 that allowed consumers to purchase books from sites such as Amazon and CDs from sites such as CDNow by answering a short set of questions. Quack followed with a set of information services from movie listings (inspired by, but expanding upon, Moviefone) to news, weather and stock quotes. This concept introduced a series of lookalike startups including Tellme Networks which raised more money than any Internet startup in history on a similar concept. Quack received its first venture funding from HDL Capital in 1999 and moved operations to Mountain View in Silicon Valley, California in 1999. A deal with Lycos was announced in May 2000. In September 2000 Quack was acquired for $200 million by America Online (AOL) and moved onto the Netscape campus with what was left of the Netscape team. Quack was attacked in the Canadian press for being representative of the Canadian "brain drain" to the US during the Internet bubble, focusing its recruiting efforts on the University of Waterloo, hiring more than 50 engineers from Waterloo in less than 10 months. Quack competitor Tellme Networks raised enormous funds in what became a highly competitive market in 2000, with the emergence of more than a dozen additional competitors in a 12-month period. Following its acquisition by America Online in an effort led by Ted Leonsis to bring Quack into AOL Interactive, the Quack voice service became AOLbyPhone as one of AOL's "web properties" along with MapQuest, Moviefone and others. Quack secured several patents that underlie the technical challenges of delivering interactive voice services. Constructing a voice portal required integrations and innovations not only in speech recognition and speech generation, but also in databases, application specification, constraint-based reasoning and artificial intelligence and computational linguistics. "Quack"'s name derived from the company goal of providing not only voice-based services, but more broadly "Quick Ubiquitous Access to Consumer Knowledge". The patents assigned to Quack.com include: System and method for voice access to Internet-based information, System and method for advertising with an Internet Voice Portal and recognizing the axiom that in interactive voice systems one must "know the set of possible answers to a question before asking it". System and method for determining if one web site has the same information as another web site. Quack.com was spoofed in The Simpsons in March 2002 in the episode "Blame It on Lisa" in which a "ComQuaak" sign is replaced by another equally crazy telecom company name. == 2010 onwards == In July 2010, quack.com became the focus of a new AOL iPad application, that was a web search experience. The product delivers web results and blends in picture, video and Twitter results. It enables you to preview the web results before you go to the site, search within each result, and flip through the results pages, making full use of the iPad's touch screen features. The iPad app was free via iTunes, but support discontinued in 2012.