Gary Bryce Fogel (born 1968) is an American biologist and computer scientist. He is the Chief Executive Officer of Natural Selection, Inc. He is most known for his applications of computational intelligence and machine learning to bioinformatics, computational biology, and industrial optimization. == Education and Research == Fogel was born and raised in La Jolla, California, graduating from La Jolla High School. He received a B.A. in biology with a minor in earth sciences from the University of California, Santa Cruz in 1991 and a Ph.D. in biology from the University of California, Los Angeles in 1998. Fogel has published over 150 peer-reviewed publications in conferences and journals, 2 edited books, and 11 patents. As CEO of Natural Selection, Inc., his research focuses on the application of computational intelligence, machine learning, and predictive analytics in areas not limited to: Viral evolution, cellular differentiation, drug discovery, RNA structure, cis-regulatory elements, cancer, and evolutionary game theory as well as the development of evolutionary algorithms and other approaches. == Service == Between 2008–2018 Gary Fogel was editor-in-chief of the Elsevier journal BioSystems. He has served previously as an associate editor for IEEE Transactions on Artificial Intelligence, IEEE Computational Intelligence Magazine (2005–2010), IEEE Transactions on Evolutionary Computation (2001–2013), IEEE Transactions on Emerging Topics in Computational Intelligence (2016–2018), IEEE/ACM Transactions on Computational Biology and Bioinformatics (2004–2008), International Journal of Bioinformatics Research and Applications (2004–2007), International Journal of Data Mining and Bioinformatics (2005–2007), as a consulting editor for the Journal of Computational Intelligence in Bioinformatics (2006–2007), and as an editorial board member of Ecological Informatics (2005–2009) and BMC Big Data Analytics (2015–2020). Within the IEEE Computational Intelligence Society, Fogel founded the Bioinformatics and Bioengineering Technical Committee and established the IEEE Computational Intelligence in Bioinformatics and Computational Biology conference series, chairing the first two meetings in 2004 and 2005 in San Diego. He co-founded the IEEE Conference on Artificial Intelligence in 2023. Fogel served on the IEEE Computational Intelligence Society Administrative Committee (2004–2009, 2014–2022) and served as IEEE CIS Vice President of Conferences (2010–2013, 2019). == Teaching == Gary Fogel also serves as adjunct faculty at San Diego State University in the department of aerospace engineering as well as in the Computational Science Research Center. He has authored four books and numerous articles on the history of early aviation focusing on motorless flight. He is an associate fellow of the American Institute of Aeronautics and Astronautics and serves on the AIAA History Committee. == Awards == 2023 – Outstanding Contribution to Aerospace Education Award, AIAA San Diego Section 2022 – Elected Fellow of the Asia-Pacific Artificial Intelligence Association 2019 – Top 100 AI Leaders in Drug Discovery and Advanced Healthcare by Deep Knowledge Analytics 2019 – Outstanding Contribution to Aerospace Education Award, AIAA San Diego Section 2016 – Meritorious Service Award, IEEE Computational Intelligence Society 2016 – Outstanding Contribution to the Community Award, AIAA San Diego Section 2015 – Outstanding Enhancement of the Image of the Aerospace Profession Award, AIAA San Diego Section 2012 – Medal for Significant Achievement, San Diego Chapter of Sigma Xi 2012 – Fellow of the Institute of Electrical and Electronics Engineers for contributions to computational intelligence and its application to biology, chemistry, and medicine. == Aeromodeling == Gary Fogel has established national and world records for model aircraft. He helped establish the National Model Aviation Heritage program for the Academy of Model Aeronautics. He is a leader member, contest director, and fellow of the Academy of Model Aeronautics, and was inducted into the Academy of Model Aeronautics Hall of Fame in 2025.
DeepRoute.ai
DeepRoute.ai (Chinese: 元戎启行) is a Chinese autonomous driving company founded in 2019 and headquartered in Shenzhen, China. The company develops full-stack self-driving solutions including perception, decision-making, and control systems. == History == DeepRoute.ai was founded in February 2019 in Shenzhen, China, by Zhou Guang (周光), who serves as the company's CEO. In September 2019, the company collaborated with Dongfeng for a live-streamed autonomous driving demonstration. In October 2019, during the 7th Military World Games, DeepRoute.ai conducted Robotaxi demonstration operations. In November 2019, it obtained an intelligent connected vehicle road test permit for public roads in Shenzhen. In October 2020, DeepRoute.ai signed an "Autonomous Driving Leadership Project" with Dongfeng to build one of China's largest autonomous fleets. In August 2020, DeepRoute.ai announced its partnership with Cao Cao Mobility, a Geely-backed ride-hailing company, to test Robotaxis in Hangzhou for daily operations, planning to provide Robotaxis during the 2022 Asian Games. In September 2021, DeepRoute.ai secured US$300 million in a Series B funding round led by Alibaba. In December 2021, the company unveiled its DeepRoute-Driver 2.0, an L4-level autonomous driving solution comprising five solid-state lidar sensors, eight cameras, a proprietary computing system and an optional millimeter-wave radar. with a production cost of under US$10,000. In June 2022, it partnered with Deppon Express to provide autonomous light truck freight transfer services. In March 2023, the company launched its high-precision map-free intelligent driving solution, DeepRoute-Driver 3.0. In November 2024, Great Wall Motor announced a $100 million Series C funding round for Deeproute. With this, Deeproute has completed five rounds of financing, raising a cumulative total of over $500 million. Its shareholders include Fosun RZ Capital, Yunqi Partners, Alibaba, Vision Plus Capital, and Dongfeng, among others. In the same month, Deeproute.ai emphasised that they were in "deep cooperation" with Nvidia and spoke on being part of the first batch of companies in China to get a hold of Nvidia's newer Thor chip for cars which will be used in a new system released next year. This new system will help manage more complex driving scenarios through visual cues. == Products == === VLA Model === VLA Model is a Vision–language–action model designed for autonomous driving systems. It integrates visual perception, semantic understanding, and action decision-making into a unified framework, aiming to enhance the safety and adaptability of advanced driver-assistance systems (ADAS) in complex road environments. The model was officially launched on August 26, 2025, as the core of DeepRoute.ai's DeepRoute IO 2.0 platform. The VLA model is characterized by its "visual-language-action" architecture, which incorporates a chain-of-thought (CoT) reasoning capability inspired by large language models. This design is intended to address the "black box" limitations of traditional end-to-end autonomous driving systems by enabling the model to analyze information, infer causality, and make decisions in a more transparent and interpretable manner. === Appliance === The company has partnered with several automakers including Dongfeng Motor Corporation and Geely to develop and test autonomous vehicles.
Facial age estimation
Facial age estimation is the use of artificial intelligence to estimate the age of a person based on their facial features. Computer vision techniques are used to analyse the facial features in the images of millions of people whose age is known and then deep learning is used to create an algorithm that tries to predict the age of an unknown person. The key use of the technology is to prevent access to age-restricted goods and services. Examples include restricting children from accessing internet pornography, checking that they meet a mandatory minimum age when registering for an account on social media, or preventing adults from accessing websites, online chat or games designed only for use by children. The technology is distinct from facial recognition systems as the software does not attempt to uniquely identify the individual. Researchers have applied neural networks for age estimation since at least 2010. == Evaluation == An ongoing study by the National Institute of Standards and Technology (NIST) entitled 'Face Analysis Technology Evaluation' seeks to establish the technical performance of prototype age estimation algorithms submitted by academic teams and software vendors including Brno University of Technology, Czech Technical University in Prague, Dermalog, IDEMIA, Incode Technologies Inc, Jumio, Nominder, Rank One Computing, Unissey and Yoti. == Public sector use == The UK government has explored using facial age estimation at the UK border as an alternative to bone X-rays and MRI scans when determining child status of asylum seekers. == Commercial use == Commercial users of facial age estimation include Instagram and OnlyFans. In January 2025, John Lewis & Partners announced that had started using the technology to check the age of people shopping for knives on its website, to comply with UK legislation to limit knife crime. In the UK, several supermarket chains have taken part in Home Office trials of the technology to automate the checking of a customer's age when buying age-restricted goods such as alcohol. UK legislation introduced in January 2025 mandates robust forms of age verification hosting adult content viewable in the UK by July 2025. Allowable methods include facial age estimation. == Criticism == Adam Schwartz, a lawyer for the Electronic Frontier Foundation, criticized the use of facial age estimation software, noting its inaccuracy especially in cases of minorities and women, as was found in NIST's 2024 report. Twenty organisations jointly under European Digital Rights called the practice a "systematic and invasive processing of young people's data" that risks discriminatory profiling.
GPTs
GPTs are custom versions of ChatGPT with added instructions and extra knowledge. GPTs can be used and created from the GPT Store. Any user can easily create them without any programming knowledge. GPTs can be tailored for specific writing styles, topics, or tasks. The ability to create GPTs was introduced in November 2023, and by January 2024, more than 3 million GPTs had been published. == Features and uses == GPTs can be configured to answer complex questions in specific fields, solve problems, provide image-based information, or create digital content. They can be programmed as educational tools, purchasing guides, or technical advisors, as well as for many others applications. GPTs are accessed from the GPT Store section of the ChatGPT web page. The “Explore GPT” link opens the store where the most popular GPTs in each section are highlighted. The GPTs are organized by categories. The store also uses a rating system based on user experiences similar to that used by other app stores such as Apple's App Store or Google Play. Those with the best ratings appear at the top of each category. According to La Vanguardia, the most popular categories are: Personal assistants Learning to program Image generation Creative writing Gaming Entertainment It is expected that in the future the creators of GPTs will be able to monetize them. Companies like Moderna are using GPTs to assist in various specific business tasks. The company has created 750 GPTs for its own internal use. == Configuration == Creating GPTs does not require prior programming knowledge. Free users can use existing GPTs but cannot create their own. Paying subscribers can use the editor on the ChatGPT site to configure the GPT's name, image and description, instructions and access to APIs, along with visibility options. == Criticism == The implementation and use of GPTs has not been without criticism. The GPT Store has been criticized for the proliferation of low-quality GPTs and spam due to a lack of effective moderation. There are also concerns about data privacy and security, as GPTs may collect and use personal information in ways that are not always transparent to users.
Database application
A database application is a computer program whose primary purpose is retrieving information from a computerized database. From here, information can be inserted, modified or deleted which is subsequently conveyed back into the database. Early examples of database applications were accounting systems and airline reservations systems, such as SABRE, developed starting in 1957. A characteristic of modern database applications is that they facilitate simultaneous updates and queries from multiple users. Systems in the 1970s might have accomplished this by having each user in front of a 3270 terminal to a mainframe computer. By the mid-1980s it was becoming more common to give each user a personal computer and have a program running on that PC that is connected to a database server. Information would be pulled from the database, transmitted over a network, and then arranged, graphed, or otherwise formatted by the program running on the PC. Starting in the mid-1990s it became more common to build database applications with a Web interface. Rather than develop custom software to run on a user's PC, the user would use the same Web browser program for every application. A database application with a Web interface had the advantage that it could be used on devices of different sizes, with different hardware, and with different operating systems. Examples of early database applications with Web interfaces include amazon.com, which used the Oracle relational database management system, the photo.net online community, whose implementation on top of Oracle was described in the book Database-Backed Web Sites (Ziff-Davis Press; May 1997), and eBay, also running Oracle. Electronic medical records are referred to on emrexperts.com, in December 2010, as "a software database application". A 2005 O'Reilly book uses the term in its title: Database Applications and the Web. Some of the most complex database applications remain accounting systems, such as SAP, which may contain thousands of tables in only a single module. Many of today's most widely used computer systems are database applications, for example, Facebook, which was built on top of MySQL. The etymology of the phrase "database application" comes from the practice of dividing computer software into systems programs, such as the operating system, compilers, the file system, and tools such as the database management system, and application programs, such as a payroll check processor. On a standard PC running Microsoft Windows, for example, the Windows operating system contains all of the systems programs while games, word processors, spreadsheet programs, photo editing programs, etc. would be application programs. As "application" is short for "application program", "database application" is short for "database application program". Not every program that uses a database would typically be considered a "database application". For example, many physics experiments, e.g., the Large Hadron Collider, generate massive data sets that programs subsequently analyze. The data sets constitute a "database", though they are not typically managed with a standard relational database management system. The computer programs that analyze the data are primarily developed to answer hypotheses, not to put information back into the database and therefore the overall program would not be called a "database application". == Examples of database applications == Amazon Student Data CNN eBay Facebook Fandango Filemaker (Mac OS) LibreOffice Base Microsoft Access Oracle relational database SAP (Systems, Applications & Products in Data Processing) Ticketmaster Wikipedia Yelp YouTube Google MySQL
Conditional random field
Conditional random fields (CRFs) are a class of statistical modeling methods often applied in pattern recognition and machine learning and used for structured prediction. Whereas a classifier predicts a label for a single sample without considering "neighbouring" samples, a CRF can take context into account. To do so, the predictions are modelled as a graphical model, which represents the presence of dependencies between the predictions. The kind of graph used depends on the application. For example, in natural language processing, "linear chain" CRFs are popular, for which each prediction is dependent only on its immediate neighbours. In image processing, the graph typically connects locations to nearby and/or similar locations to enforce that they receive similar predictions. Other examples where CRFs are used are: labeling or parsing of sequential data for natural language processing or biological sequences, part-of-speech tagging, shallow parsing, named entity recognition, gene finding, peptide critical functional region finding, and object recognition and image segmentation in computer vision. == Description == CRFs are a type of discriminative undirected probabilistic graphical model. Lafferty, McCallum and Pereira define a CRF on observations X {\displaystyle {\boldsymbol {X}}} and random variables Y {\displaystyle {\boldsymbol {Y}}} as follows: Let G = ( V , E ) {\displaystyle G=(V,E)} be a graph such that Y = ( Y v ) v ∈ V {\displaystyle {\boldsymbol {Y}}=({\boldsymbol {Y}}_{v})_{v\in V}} , so that Y {\displaystyle {\boldsymbol {Y}}} is indexed by the vertices of G {\displaystyle G} . Then ( X , Y ) {\displaystyle ({\boldsymbol {X}},{\boldsymbol {Y}})} is a conditional random field when each random variable Y v {\displaystyle {\boldsymbol {Y}}_{v}} , conditioned on X {\displaystyle {\boldsymbol {X}}} , obeys the Markov property with respect to the graph; that is, its probability is dependent only on its neighbours in G and not its past states: P ( Y v | X , { Y w : w ≠ v } ) = P ( Y v | X , { Y w : w ∼ v } ) {\displaystyle P({\boldsymbol {Y}}_{v}|{\boldsymbol {X}},\{{\boldsymbol {Y}}_{w}:w\neq v\})=P({\boldsymbol {Y}}_{v}|{\boldsymbol {X}},\{{\boldsymbol {Y}}_{w}:w\sim v\})} , where w ∼ v {\displaystyle {\mathit {w}}\sim v} means that w {\displaystyle w} and v {\displaystyle v} are neighbors in G {\displaystyle G} . What this means is that a CRF is an undirected graphical model whose nodes can be divided into exactly two disjoint sets X {\displaystyle {\boldsymbol {X}}} and Y {\displaystyle {\boldsymbol {Y}}} , the observed and output variables, respectively; the conditional distribution p ( Y | X ) {\displaystyle p({\boldsymbol {Y}}|{\boldsymbol {X}})} is then modeled. === Inference === For general graphs, the problem of exact inference in CRFs is intractable. The inference problem for a CRF is basically the same as for an MRF and the same arguments hold. However, there exist special cases for which exact inference is feasible: If the graph is a chain or a tree, message passing algorithms yield exact solutions. The algorithms used in these cases are analogous to the forward-backward and Viterbi algorithm for the case of HMMs. If the CRF only contains pair-wise potentials and the energy is submodular, combinatorial min cut/max flow algorithms yield exact solutions. If exact inference is impossible, several algorithms can be used to obtain approximate solutions. These include: Loopy belief propagation Alpha expansion Mean field inference Linear programming relaxations === Parameter learning === Learning the parameters θ {\displaystyle \theta } is usually done by maximum likelihood learning for p ( Y i | X i ; θ ) {\displaystyle p(Y_{i}|X_{i};\theta )} . If all nodes have exponential family distributions and all nodes are observed during training, this optimization is convex. It can be solved for example using gradient descent algorithms, or Quasi-Newton methods such as the L-BFGS algorithm. On the other hand, if some variables are unobserved, the inference problem has to be solved for these variables. Exact inference is intractable in general graphs, so approximations have to be used. === Examples === In sequence modeling, the graph of interest is usually a chain graph. An input sequence of observed variables X {\displaystyle X} represents a sequence of observations and Y {\displaystyle Y} represents a hidden (or unknown) state variable that needs to be inferred given the observations. The Y i {\displaystyle Y_{i}} are structured to form a chain, with an edge between each Y i − 1 {\displaystyle Y_{i-1}} and Y i {\displaystyle Y_{i}} . As well as having a simple interpretation of the Y i {\displaystyle Y_{i}} as "labels" for each element in the input sequence, this layout admits efficient algorithms for: model training, learning the conditional distributions between the Y i {\displaystyle Y_{i}} and feature functions from some corpus of training data. decoding, determining the probability of a given label sequence Y {\displaystyle Y} given X {\displaystyle X} . inference, determining the most likely label sequence Y {\displaystyle Y} given X {\displaystyle X} . The conditional dependency of each Y i {\displaystyle Y_{i}} on X {\displaystyle X} is defined through a fixed set of feature functions of the form f ( i , Y i − 1 , Y i , X ) {\displaystyle f(i,Y_{i-1},Y_{i},X)} , which can be thought of as measurements on the input sequence that partially determine the likelihood of each possible value for Y i {\displaystyle Y_{i}} . The model assigns each feature a numerical weight and combines them to determine the probability of a certain value for Y i {\displaystyle Y_{i}} . Linear-chain CRFs have many of the same applications as conceptually simpler hidden Markov models (HMMs), but relax certain assumptions about the input and output sequence distributions. An HMM can loosely be understood as a CRF with very specific feature functions that use constant probabilities to model state transitions and emissions. Conversely, a CRF can loosely be understood as a generalization of an HMM that makes the constant transition probabilities into arbitrary functions that vary across the positions in the sequence of hidden states, depending on the input sequence. Notably, in contrast to HMMs, CRFs can contain any number of feature functions, the feature functions can inspect the entire input sequence X {\displaystyle X} at any point during inference, and the range of the feature functions need not have a probabilistic interpretation. == Variants == === Higher-order CRFs and semi-Markov CRFs === CRFs can be extended into higher order models by making each Y i {\displaystyle Y_{i}} dependent on a fixed number k {\displaystyle k} of previous variables Y i − k , . . . , Y i − 1 {\displaystyle Y_{i-k},...,Y_{i-1}} . In conventional formulations of higher order CRFs, training and inference are only practical for small values of k {\displaystyle k} (such as k ≤ 5), since their computational cost increases exponentially with k {\displaystyle k} . However, another recent advance has managed to ameliorate these issues by leveraging concepts and tools from the field of Bayesian nonparametrics. Specifically, the CRF-infinity approach constitutes a CRF-type model that is capable of learning infinitely-long temporal dynamics in a scalable fashion. This is effected by introducing a novel potential function for CRFs that is based on the Sequence Memoizer (SM), a nonparametric Bayesian model for learning infinitely-long dynamics in sequential observations. To render such a model computationally tractable, CRF-infinity employs a mean-field approximation of the postulated novel potential functions (which are driven by an SM). This allows for devising efficient approximate training and inference algorithms for the model, without undermining its capability to capture and model temporal dependencies of arbitrary length. There exists another generalization of CRFs, the semi-Markov conditional random field (semi-CRF), which models variable-length segmentations of the label sequence Y {\displaystyle Y} . This provides much of the power of higher-order CRFs to model long-range dependencies of the Y i {\displaystyle Y_{i}} , at a reasonable computational cost. Finally, large-margin models for structured prediction, such as the structured Support Vector Machine can be seen as an alternative training procedure to CRFs. === Latent-dynamic conditional random field === Latent-dynamic conditional random fields (LDCRF) or discriminative probabilistic latent variable models (DPLVM) are a type of CRFs for sequence tagging tasks. They are latent variable models that are trained discriminatively. In an LDCRF, like in any sequence tagging task, given a sequence of observations x = x 1 , … , x n {\displaystyle x_{1},\dots ,x_{n}} , the main problem the model must solve is how to assign a sequence of labels y = y 1 , … , y n {\displaystyle y_{1},\dots ,y_{n}} from one finite set
Apache OpenNLP
The Apache OpenNLP library is a machine learning based toolkit for the processing of natural language text. It supports the most common NLP tasks, such as language detection, tokenization, sentence segmentation, part-of-speech tagging, named entity extraction, chunking, parsing and coreference resolution. These tasks are usually required to build more advanced text processing services.