TargetLink is a software for automatic code generation, based on a subset of Simulink/Stateflow models, produced by dSPACE GmbH. TargetLink requires an existing MATLAB/Simulink model to work on. TargetLink generates both ANSI-C and production code optimized for specific processors. It also supports the generation of AUTOSAR-compliant code for software components for the automotive sector. The management of all relevant information for code generation takes place in a central data container, called the Data Dictionary. Testing of the generated code is implemented in Simulink, which is also used for the specification of the underlying simulation models. TargetLink supports three simulation modes to test the generated code: Model-in-the-loop simulation (MIL): this mode allows the model design to be checked. An MIL simulation is also known as a floating-point simulation, since the variables are typically floating-point variables. Software-in-the-loop (SIL): the simulation is based on the execution of generated code, which runs on a PC system. The variables are typically plain or fixed point numbers. Processor-in-the-loop (PIL): in a PIL simulation, the generated code runs on the target hardware or on an evaluation board. So-called real-time frames are included, making it possible to transfer the simulation results as well as memory consumption and runtime information to the PC. The Motor Industry Software Reliability Association (MISRA) published official MISRA modeling guidelines for TargetLink in late 2007, which are particularly important for functional safety of safety-critical applications. In 2009, TÜV SÜD certified TargetLink for use during the development of safety-critical systems to ISO DIS 26262 and IEC 61508.
Tute Genomics
Tute Genomics was an American genomics startup that provided a cloud-based web application for rapid and accurate annotation of human genomic data. It was built on the expertise of ANNOVAR. Tute Genomics assisted researchers in identifying disease genes and biomarkers, and assisted clinicians/labs in performing genetic diagnosis. Based in Provo, Utah, Tute was co-founded by Dr. Kai Wang, an assistant professor at the University of Southern California (USC); and Dr. Reid J. Robison, a board-certified psychiatrist with fellowship training in both neurodevelopmental genetics and bioinformatics. Tute Genomics was acquired by PierianDX in 2016. == History == The word "tute" means "personal" in the Na’vi language created for the 2009 film Avatar by Paul Frommer, a linguist and communications professor at the USC Marshall School of Business. === Timeline === 2013 Tute Genomics launched in 2013 and entered the accelerator, BoomStartup. By "demo day" of BoomStartup, Tute had raised their seed round of funding and expanded the round to include angel investors from SLC Angels, Park City Angels, Life Science Angels. Tute was the tenth ever online syndicate for AngelList and in all raised a seed round of $1.5 million. 2014 In March 2014, the company announced that Affiliated Genetics, a Utah-based CLIA-certified laboratory, selected Tute Genomics for its next-generation sequencing (NGS) analytics pipeline. In May 2014, the company announced joining the Global Alliance for Genomics and Health. In June 2014, Advanced Biological Laboratories (ABL), S.A., announced a licensing and collaboration agreement with Tute Genomics and the commercial launch of OncoChek for managing and analysing genomics data in the field of oncology. In July 2014, the company announced an agreement with Lineagen, Inc., to provide next-generation sequencing analytics for Lineagen’s NextStepDx Plus assay. Also, Brigham Young University selected the Tute Genomics genome annotation and discovery platform for analysis and interpretation of 1,000 exomes and genomes. In November 2014, the company announced addition of the Tute platform to Illumina’s BaseSpace. The company announced a Series A1 funding round of $2.3 million in December 2014. The round was led by UK-based Eurovestech. Peak Ventures and a number of angel investors also participated in this round. 2015 Tute recruits David Mittelman, founder of Arpeggi, Inc. and former CSO at FamilyTreeDNA, to Tute Genomics as Chief Scientific Officer. Tute acquires Knome and integrates the KnoSys platform into its software product. 2016 Reid Robison, Tute CEO, launches a Kickstarter campaign to sell Tute interpreted whole genome and whole exome sequencing directly to consumers. The campaign was suspended within the same month after receiving a letter from the United States Food and Drug Administration. Tute is acquired by PierianDX.
Is an AI Voice Assistant Worth It in 2026?
Trying to pick the best AI voice assistant? An AI voice assistant is software that uses machine learning to help you get more done — it scales effortlessly from a single task to thousands. The best picks balance beginner-friendly simplicity with the depth power users need, and they ship updates often. Whether you are a beginner or a pro, the right AI voice assistant slots into your workflow and pays for itself fast. Read on for hands-on impressions, pricing tiers, and the standout features that matter.
The Best Free AI Chatbot for Beginners
Trying to pick the best AI chatbot? An AI chatbot is software that uses machine learning to help you get more done — it scales effortlessly from a single task to thousands. The best picks balance beginner-friendly simplicity with the depth power users need, and they ship updates often. Whether you are a beginner or a pro, the right AI chatbot slots into your workflow and pays for itself fast. This guide breaks down the top picks, their pros and cons, and who each one is best for.
Frederick Jelinek
Frederick Jelinek (18 November 1932 – 14 September 2010) was a Czech-American researcher in information theory, automatic speech recognition, and natural language processing. He is well known for his oft-quoted statement, "Every time I fire a linguist, the performance of the speech recognizer goes up". Jelinek was born in Czechoslovakia before World War II and emigrated with his family to the United States in the early years of the communist regime. He studied engineering at the Massachusetts Institute of Technology and taught for 10 years at Cornell University before accepting a job at IBM Research. In 1961, he married Czech screenwriter Milena Jelinek. At IBM, his team advanced approaches to computer speech recognition and machine translation. After IBM, he went to head the Center for Language and Speech Processing at Johns Hopkins University for 17 years, where he was still working on the day he died. == Personal life == Jelinek was born on November 18, 1932, as Bedřich Jelínek in Kladno to Vilém and Trude Jelínek. His father was Jewish; his mother was born in Switzerland to Czech Catholic parents and had converted to Judaism. Jelínek senior, a dentist, had planned early to escape Nazi occupation and flee to England; he arranged for a passport, visa, and the shipping of his dentistry materials. The couple planned to send their son to an English private school. However, Vilém decided to stay at the last minute and was eventually sent to the Theresienstadt concentration camp, where he died in 1945. The family was forced to move to Prague in 1941, but Frederick, his sister and mother—thanks to the latter's background—escaped the concentration camps. After the war, Jelinek entered in the gymnasium, despite having missed several years of schooling because education of Jewish children had been forbidden since 1942. His mother, anxious that her son should get a good education, made great efforts for their emigration, especially when it became clear he would not be allowed to even attempt the graduation examination. His mother hoped her son would become a physician, but Jelinek dreamed of being a lawyer. He studied engineering in evening classes at the City College of New York and received stipends from the National Committee for a Free Europe that allowed him to study at the Massachusetts Institute of Technology. About his choice of specialty, he said: "Fortunately, to electrical engineering there belonged a discipline whose aim was not the construction of physical systems: the theory of information". He obtained his Ph.D. in 1962, with Robert Fano as his adviser. In 1957, Jelinek paid an unexpected visit to Prague. He had been in Vienna and applied for a visa, hoping to see his former acquaintances again. He met with his old friend Miloš Forman, who introduced him to film student Milena Tobolová—whose screenplay had been the basis for the movie Easy Life (Snadný život). His flight back to the U.S. had a stopover in Munich, during which he called her to propose. Tobolová was considered a dissident and the authorities were not happy with her film. Jelinek asked for help from Jerome Wiesner and Cyrus Eaton, the latter who lobbied Nikita Khrushchev. Following the inauguration of John F. Kennedy, a group of Czech dissidents were allowed to emigrate in January 1961. Thanks to the lobbying, the future Milena Jelinek was one of them. After completing his graduate studies, Jelinek, who had developed an interest in linguistics, had plans to work with Charles F. Hockett at Cornell University. However these fell through and during the next ten years he continued to study information theory. Having previously worked at IBM during a sabbatical, he began full-time work there in 1972—at first on leave for Cornell, but permanently from 1974. He remained there for over twenty years. Although at first he had been offered a regular research job, upon his arrival he learned that Josef Raviv had recently been promoted to head of the newly opened IBM Haifa Research Laboratory, and became head of the Continuous Speech Recognition group at the Thomas J. Watson Research Center. Despite his team's successes in this area, Jelinek's work remained little known in his home country because Czech scientists were not allowed to participate in key conferences. After the 1989 fall of communism, Jelinek helped establish scientific relationships, regularly visiting to lecture and helping to persuade IBM to establish a computing centre at Charles University. In 1993, he retired from IBM and went to Johns Hopkins University's Center for Language and Speech Processing, where he was director and Julian Sinclair Smith Professor of Electrical and Computer Engineering. He was still working there at the time of his death; Jelinek died of a heart attack at the close of an otherwise normal workday in mid-September 2010. He was survived by his wife, daughter and son, sister, stepsister, and three grandchildren, including Sophie Gold Jelinek. == Research and legacy == Information theory was a fashionable scientific approach in the mid '50s. However, pioneer Claude Shannon wrote in 1956 that this trendiness was dangerous. He said, "Our fellow scientists in many different fields, attracted by the fanfare and by the new avenues opened to scientific analysis, are using these ideas in their own problems ... It will be all too easy for our somewhat artificial prosperity to collapse overnight when it is realized that the use of a few exciting words like information, entropy, redundancy, do not solve all our problems." During the next decade, a combination of factors shut down the application of information theory to natural language processing (NLP) problems—in particular machine translation. One factor was the 1957 publication of Noam Chomsky's Syntactic Structures, which stated, "probabilistic models give no insight into the basic problems of syntactic structure". This accorded well with the philosophy of the artificial intelligence research of the time, which promoted rule-based approaches. The other factor was the 1966 ALPAC report, which recommended that the government should stop funding research into machine translation. ALPAC chairman John Pierce later said that the field was filled with "mad inventors or untrustworthy engineers". He said that the underlying linguistic problems must be solved before attempts at NLP could be reasonably made. These elements essentially halted research in the field. Jelinek had begun to develop an interest in linguistics after the immigration of his wife, who initially enrolled in the MIT linguistics program with the help of Roman Jakobson. Jelinek often accompanied her to Chomsky's lectures, and even discussed the possibility of changing orientation with his adviser. Fano was "really upset", and after the failure of his project with Hockett at Cornell, he did not return to this field of research until starting work at IBM. The scope of research at IBM was considerably different from that of most other teams. According to Mark Liberman, "While [Jelinek] was leading IBM's effort to solve the general dictation problem during the decade or so following 1972, most other U.S. companies and academic researchers were working on very limited problems ... or were staying out of the field entirely". Jelinek regarded speech recognition as an information theory problem—a noisy channel, in this case the acoustic signal—which some observers considered a daring approach. The concept of perplexity was introduced in their first model, New Raleigh Grammar, which was published in 1976 as the paper "Continuous Speech Recognition by Statistical Methods" in the journal Proceedings of the IEEE. According to Young, the basic noisy channel approach "reduced the speech recognition problem to one of producing two statistical models". Whereas New Raleigh Grammar was a hidden Markov model, their next model, called Tangora, was broader and involved n-grams, specifically trigrams. Even though "it was obvious to everyone that this model was hopelessly impoverished", it was not improved upon until Jelinek presented another paper in 1999. The same trigram approach was applied to phones in single words. Although the identification of parts of speech turned out not to be very useful for speech recognition, tagging methods developed during these projects are now used in various NLP applications. The incremental research techniques developed at IBM eventually became dominant in the field after DARPA, in the mid-80s, returned to NLP research and imposed that methodology to participating teams, shared common goals, data, and precise evaluation metrics. The Continuous Speech Recognition Group's research, which required large amounts of data to train the algorithms, eventually led to the creation of the Linguistic Data Consortium. In the 1980s, although the broader problem of speech recognition remained unsolved, they sought to apply the methods developed to other problems; machine translat
Brain technology
Brain technology, or self-learning know-how systems, defines a technology that employs latest findings in neuroscience. [see also neuro implants] The term was first introduced by the Artificial Intelligence Laboratory in Zurich, Switzerland, in the context of the Roboy project. Brain Technology can be employed in robots, know-how management systems and any other application with self-learning capabilities. In particular, Brain Technology applications allow the visualization of the underlying learning architecture often coined as "know-how maps". == Research and applications == The first demonstrations of BC in humans and animals took place in the 1960s when Grey Walter demonstrated use of non-invasively recorded encephalogram (EEG) signals from a human subject to control a slide projector (Graimann et al., 2010). Soon after Jacques J. Vidal coined the term brain–computer interface (BCI) in 1971, the Defense Advanced Research Projects Agency (DARPA) first starting funding brain–computer interface research and has since funded several brain–computer interface projects. That market is expected to reach a value of $1.72 billion by 2022. Brain–computer interfaces record brain activity, transmit the information out of the body, signal-process the data via algorithms, and convert them into command control signals. In 2012, a landmark study in Nature, led by pioneer Leigh Hochberg, MD, PhD, demonstrated that two people with tetraplegia were able to control robotic arms through thought when connected to the BrainGate neural interface system. The two participants were able to reach for and grasp objects in three-dimensional space, and one participant used the system to serve herself coffee for the first time since becoming paralyzed nearly 15 years prior. And in October 2020, two patients were able to wirelessly control an operating system to text, email, shop and bank using direct thought through the Stentrode brain computer interface (Journal of NeuroInterventional Surgery) in a study led by Thomas Oxley. This was the first time a brain–computer interface was implanted via the patient's blood vessels, eliminating the need for open brain surgery. Currently a number of groups are exploring a range of experimental devices using brain–computer interfaces, which have the potential to fundamentally change the way of life for patients with paralysis and a wide range of neurological disorders. These include: as Elon Musk, Facebook, and the University of California in San Francisco. The systems. This technology is also being explored as a neuromodulation device and may ultimately help diagnose and treat a range of brain pathologies, such as epilepsy and Parkinson's disease.
Unsupervised learning
Unsupervised learning is a framework in machine learning where, in contrast to supervised learning, algorithms learn patterns exclusively from unlabeled data. Other frameworks in the spectrum of supervisions include weak- or semi-supervision, where a small portion of the data is tagged, and self-supervision. Some researchers consider self-supervised learning a form of unsupervised learning. Conceptually, unsupervised learning divides into the aspects of data, training, algorithm, and downstream applications. Typically, the dataset is harvested cheaply "in the wild", such as massive text corpus obtained by web crawling, with only minor filtering (such as Common Crawl). This compares favorably to supervised learning, where the dataset (such as the ImageNet1000) is typically constructed manually, which is much more expensive. There are algorithms designed specifically for unsupervised learning, such as clustering algorithms like k-means, dimensionality reduction techniques like principal component analysis (PCA), Boltzmann machine learning, and autoencoders. After the rise of deep learning, most large-scale unsupervised learning has been done by training general-purpose neural network architectures by gradient descent, adapted to performing unsupervised learning by designing an appropriate training procedure. Sometimes a trained model can be used as-is, but more often they are modified for downstream applications. For example, the generative pretraining method trains a model to generate a textual dataset, before finetuning it for other applications, such as text classification. As another example, autoencoders are trained to produce good features, which can then be used as a module for other models, such as in a latent diffusion model. == Tasks == Tasks are often categorized as discriminative (recognition) or generative (imagination). Often but not always, discriminative tasks use supervised methods and generative tasks use unsupervised (see Venn diagram); however, the separation is very hazy. For example, object recognition favors supervised learning but unsupervised learning can also cluster objects into groups. Furthermore, as progress marches onward, some tasks employ both methods, and some tasks swing from one to another. For example, image recognition started off as heavily supervised, but became hybrid by employing unsupervised pre-training, and then moved towards supervision again with the advent of dropout, ReLU, and adaptive learning rates. A typical generative task is as follows. At each step, a datapoint is sampled from the dataset, and part of the data is removed, and the model must infer the removed part. This is particularly clear for the denoising autoencoders and BERT. == Neural network architectures == === Training === During the learning phase, an unsupervised network tries to mimic the data it is given and uses the error in its mimicked output to correct itself (i.e. correct its weights and biases). Sometimes the error is expressed as a low probability that the erroneous output occurs, or it might be expressed as an unstable high energy state in the network. In contrast to supervised methods' dominant use of backpropagation, unsupervised learning also employs other methods including: Hopfield learning rule, Boltzmann learning rule, Contrastive Divergence, Wake Sleep, Variational Inference, Maximum Likelihood, Maximum A Posteriori, Gibbs Sampling, and backpropagating reconstruction errors or hidden state reparameterizations. See the table below for more details. === Energy === An energy function is a macroscopic measure of a network's activation state. In Boltzmann machines, it plays the role of the Cost function. This analogy with physics is inspired by Ludwig Boltzmann's analysis of a gas' macroscopic energy from the microscopic probabilities of particle motion p ∝ e − E / k T {\displaystyle p\propto e^{-E/kT}} , where k is the Boltzmann constant and T is temperature. In the RBM network the relation is p = e − E / Z {\displaystyle p=e^{-E}/Z} , where p {\displaystyle p} and E {\displaystyle E} vary over every possible activation pattern and Z = ∑ All Patterns e − E ( pattern ) {\displaystyle \textstyle {Z=\sum _{\scriptscriptstyle {\text{All Patterns}}}e^{-E({\text{pattern}})}}} . To be more precise, p ( a ) = e − E ( a ) / Z {\displaystyle p(a)=e^{-E(a)}/Z} , where a {\displaystyle a} is an activation pattern of all neurons (visible and hidden). Hence, some early neural networks bear the name Boltzmann Machine. Paul Smolensky calls − E {\displaystyle -E\,} the Harmony. A network seeks low energy which is high Harmony. === Networks === This table shows connection diagrams of various unsupervised networks, the details of which will be given in the section Comparison of Networks. Circles are neurons and edges between them are connection weights. As network design changes, features are added on to enable new capabilities or removed to make learning faster. For instance, neurons change between deterministic (Hopfield) and stochastic (Boltzmann) to allow robust output, weights are removed within a layer (RBM) to hasten learning, or connections are allowed to become asymmetric (Helmholtz). Of the networks bearing people's names, only Hopfield worked directly with neural networks. Boltzmann and Helmholtz came before artificial neural networks, but their work in physics and physiology inspired the analytical methods that were used. === History === === Specific Networks === Here, we highlight some characteristics of select networks. The details of each are given in the comparison table below. Hopfield Network Ferromagnetism inspired Hopfield networks. A neuron corresponds to an iron domain with binary magnetic moments Up and Down, and neural connections correspond to the domain's influence on each other. Symmetric connections enable a global energy formulation. During inference the network updates each state using the standard activation step function. Symmetric weights and the right energy functions guarantees convergence to a stable activation pattern. Asymmetric weights are difficult to analyze. Hopfield nets are used as Content Addressable Memories (CAM). Boltzmann Machine These are stochastic Hopfield nets. Their state value is sampled from this pdf as follows: suppose a binary neuron fires with the Bernoulli probability p(1) = 1/3 and rests with p(0) = 2/3. One samples from it by taking a uniformly distributed random number y, and plugging it into the inverted cumulative distribution function, which in this case is the step function thresholded at 2/3. The inverse function = { 0 if x <= 2/3, 1 if x > 2/3 }. Sigmoid Belief Net Introduced by Radford Neal in 1992, this network applies ideas from probabilistic graphical models to neural networks. A key difference is that nodes in graphical models have pre-assigned meanings, whereas Belief Net neurons' features are determined after training. The network is a sparsely connected directed acyclic graph composed of binary stochastic neurons. The learning rule comes from Maximum Likelihood on p(X): Δwij ∝ {\displaystyle \propto } sj (si - pi), where pi = 1 / ( 1 + eweighted inputs into neuron i ). sj's are activations from an unbiased sample of the posterior distribution and this is problematic due to the Explaining Away problem raised by Judea Perl. Variational Bayesian methods uses a surrogate posterior and blatantly disregard this complexity. Deep Belief Network Introduced by Hinton, this network is a hybrid of RBM and Sigmoid Belief Network. The top 2 layers is an RBM and the second layer downwards form a sigmoid belief network. One trains it by the stacked RBM method and then throw away the recognition weights below the top RBM. As of 2009, 3-4 layers seems to be the optimal depth. Helmholtz machine These are early inspirations for the Variational Auto Encoders. Its 2 networks combined into one—forward weights operates recognition and backward weights implements imagination. It is perhaps the first network to do both. Helmholtz did not work in machine learning but he inspired the view of "statistical inference engine whose function is to infer probable causes of sensory input". the stochastic binary neuron outputs a probability that its state is 0 or 1. The data input is normally not considered a layer, but in the Helmholtz machine generation mode, the data layer receives input from the middle layer and has separate weights for this purpose, so it is considered a layer. Hence this network has 3 layers. Variational autoencoder These are inspired by Helmholtz machines and combines probability network with neural networks. An Autoencoder is a 3-layer CAM network, where the middle layer is supposed to be some internal representation of input patterns. The encoder neural network is a probability distribution qφ(z given x) and the decoder network is pθ(x given z). The weights are named phi & theta rather than W and V as in Helmholtz—a cosmetic difference. These 2 networks h