Intel Threat Detection Technology (TDT) is a CPU-level technology created by Intel in 2018 to enable host endpoint protections to use a CPU's low-level access to detect threats to a system. TDT consists of multiple components including Accelerated Memory Scanning, which uses the CPU's integrated GPU to scan memory, and Advanced Platform Telemetry, which uses processor-level activity monitoring to detect unusual activity. It is supported on sixth-generation or newer Intel Core CPUs and additional capabilities were added to the 11th generation Core processors. Intel TDT is integrated into several third-party anti-malware solutions including Microsoft Defender, Check Point Harmony Endpoint, CrowdStrike Falcon, and others. == Accelerated Memory Scanning == Accelerated Memory Scanning (also referred to as "Advanced Memory Scanning") uses the CPU's integrated GPU to scan memory for malicious code, instead of using the CPU directly. This improves system responsiveness during anti-malware scanning. and lowers power consumption. Features include pattern matching, using random forest decision trees, string extraction, entropy calculation, and Euclidean clustering. == Advanced Platform Telemetry == Advanced Platform Telemetry collects CPU-level telemetry to detect uncommon activity patterns which might be indicative of malware. The telemetry data is collected from the CPU performance monitoring unit (PMU) and doesn't require a large signature database to detect malware. Instead, it uses machine-learning based correlations to identify indicators of attack For example, Microsoft Defender is able to use TDT's Advanced Platform Telemetry features to detect processor usage patterns indicative of ransomware and cryptojacking with TDT so it can detect them.
Hekaton (database)
Hekaton (also known as SQL Server In-Memory OLTP) is an in-memory database for OLTP workloads built into Microsoft SQL Server. Hekaton was designed in collaboration with Microsoft Research and was released in SQL Server 2014. Traditional RDBMS systems were designed when memory resources were expensive, and were optimized for disk storage. Hekaton is instead optimized for a working set stored entirely in main memory, but is still accessible via T-SQL like normal tables. It is fundamentally different from the "DBCC PINTABLE" feature in earlier SQL Server versions. Hekaton was announced at the Professional Association for SQL Server (PASS) conference 2012.
Bin Yang
Bin Yang (Chinese: 杨彬; Pinyin: Yáng Bīn) is a professor of computer science the department of computer science, Aalborg University. His research interests include data management and machine learning. == Education and career == Bin Yang received his bachelor and master degrees from Northwestern Polytechnical University, China in 2004 and 2007, respectively, and his Ph.D. from Fudan University in China in 2010. From 2010 to 2011, he worked at the Databases and Information Systems department at Max-Planck-Institut für Informatik in Germany. From 2011 to 2014, he was employed at the department of computer science, Aarhus University. He has been employed at Aalborg University since 2014. At the present moment, he works on a number of different projects: Time Series Analytics and Spatio-temporal Data Management, funded by Huawei, 2020 - 2022. Light-AI for Cognitive Power Electronics, funded by Villum Synergy Programme, 2020 - 2022. Advance: A Data-Intensive Paradigm for Dynamic, Uncertain Networks, funded by Independent Research Fund Denmark, 2019 - 2023. Algorithmic Foundations for Data-Intensive Routing, funded by The Danish Agency for Science and Higher Education, 2019 - 2021. Astra: AnalyticS of Time seRies in spAtial networks, funded by Independent Research Fund Denmark, 2018 - 2021. Distinguished Scholar, funded by The Technical Faculty of IT and Design, Aalborg University, 2018 - 2021. == Awards == Bin Yang has received a series of awards throughout his career: Sapere Aude Research Leader, Independent Research Fund Denmark, 2018. Distinguished Scholar, The Technical Faculty of IT and Design, Aalborg University, 2018. Early Career Distinguished Lecturer, 20th IEEE International Conference on Mobile Data Management (MDM), 2019. Distinguished Program Committee Member, 28th International Joint Conference on Artificial Intelligence (IJCAI), 2019 Best paper award at IEEE 14th International Conference on Mobile Data Management (MDM2013), Milan, Italy Best demo award at IEEE 14th International Conference on Mobile Data Management (MDM2013), Milan, Italy 2015 best paper in Pervasive and Embedded Computing, Shanghai Computer Academy == Selected publications == Sean Bin Yang, Chenjuan Guo, Jilin Hu, Jian Tang, and Bin Yang. Unsupervised Path Representation Learning with Curriculum Negative Sampling. IJCAI 2021. Razvan-Gabriel Cirstea, Tung Kieu, Chenjuan Guo, Bin Yang, and Sinno Jialin Pan. EnhanceNet: Plugin Neural Networks for Enhancing Correlated Time Series Forecasting. ICDE 2021. Sean Bin Yang, Chenjuan Guo, and Bin Yang. Context-Aware Path Ranking in Road Networks. TKDE 2021. Simon Aagaard Pedersen, Bin Yang, and Christian S. Jensen. Anytime Stochastic Routing with Hybrid Learning. PVLDB 13(9): 1555-1567 (2020). Tung Kieu, Bin Yang, Chenjuan Guo, and Christian S. Jensen. Outlier Detection for Time Series with Recurrent Autoencoder Ensembles. IJCAI 2019, 2725–2732. Jilin Hu, Chenjuan Guo, Bin Yang, and Christian S. Jensen. Stochastic Weight Completion for Road Networks using Graph Convolutional Networks. ICDE 2019, 1274–1285. Chenjuan Guo, Bin Yang, Jilin Hu, and Christian S. Jensen. Learning to Route with Sparse Trajectory Sets. ICDE 2018, 1073–1084. Bin Yang, Jian Dai, Chenjuan Guo, Christian S. Jensen, and Jilin Hu. PACE: A PAth-CEntric Paradigm For Stochastic Path Finding. The VLDB Journal 27(2): 153-178 (2018). Jian Dai, Bin Yang, Chenjuan Guo, and Zhiming Ding. Personalized Route Recommendation using Big Trajectory Data. ICDE 2015, 543–554, Seoul, Korea, April 2015. Bin Yang, Manohar Kaul, and Christian S. Jensen. Using Incomplete Information for Complete Weight Annotation of Road Networks. TKDE 26(5):1267-1279. Bin Yang, Chenjuan Guo, and Christian S. Jensen. Travel Cost Inference from Sparse, Spatio-Temporally Correlated Time Series Using Markov Models. PVLDB 6(9):769-780. VLDB 2013, Riva del Garda, Trento, Italy, August 2013.
Nando de Freitas
Nando de Freitas is a researcher in the field of machine learning, and in particular in the subfields of neural networks, Bayesian inference and Bayesian optimization, and deep learning. == Biography == De Freitas was born in Zimbabwe. He did his undergraduate studies (1991–94) and MSc (1994–96) at the University of the Witwatersrand, and his PhD at Trinity College, Cambridge (1996-2000). From 2001, he was a professor at the University of British Columbia, before joining the Department of Computer Science at the University of Oxford from 2013 to 2017. In 2014, he joined Google's DeepMind when the company acquired Oxford spinoff Dark Blue Labs. He was in charge of the team that worked on creating tools for generating audio and images at DeepMind. In September 2024, de Freitas joined Microsoft AI as VP of AI. == Awards and recognition == De Freitas has been recognised for his contributions to machine learning through the following awards: Best Paper Award at the International Conference on Machine Learning (2016) Best Paper Award at the International Conference on Learning Representations (2016) Google Faculty Research Award (2014) Distinguished Paper Award at the International Joint Conference on Artificial Intelligence (2013) Charles A. McDowell Award for Excellence in Research (2012) Mathematics of Information Technology and Complex Systems Young Researcher Award (2010)
Pachinko allocation
In machine learning and natural language processing, the pachinko allocation model (PAM) is a topic model. Topic models are a suite of algorithms to uncover the hidden thematic structure of a collection of documents. The algorithm improves upon earlier topic models such as latent Dirichlet allocation (LDA) by modeling correlations between topics in addition to the word correlations which constitute topics. PAM provides more flexibility and greater expressive power than latent Dirichlet allocation. While first described and implemented in the context of natural language processing, the algorithm may have applications in other fields such as bioinformatics. The model is named for pachinko machines—a game popular in Japan, in which metal balls bounce down around a complex collection of pins until they land in various bins at the bottom. == History == Pachinko allocation was first described by Wei Li and Andrew McCallum in 2006. The idea was extended with hierarchical Pachinko allocation by Li, McCallum, and David Mimno in 2007. In 2007, McCallum and his colleagues proposed a nonparametric Bayesian prior for PAM based on a variant of the hierarchical Dirichlet process (HDP). The algorithm has been implemented in the MALLET software package published by McCallum's group at the University of Massachusetts Amherst. == Model == PAM connects words in V and topics in T with an arbitrary directed acyclic graph (DAG), where topic nodes occupy the interior levels and the leaves are words. The probability of generating a whole corpus is the product of the probabilities for every document: P ( D | α ) = ∏ d P ( d | α ) {\displaystyle P(\mathbf {D} |\alpha )=\prod _{d}P(d|\alpha )}
Single particle analysis
Single particle analysis is a group of related computerized image processing techniques used to analyze images from transmission electron microscopy (TEM). These methods were developed to improve and extend the information obtainable from TEM images of particulate samples, typically proteins or other large biological entities such as viruses. Individual images of stained or unstained particles are very noisy, making interpretation difficult. Combining several digitized images of similar particles together gives an image with stronger and more easily interpretable features. An extension of this technique uses single particle methods to build up a three-dimensional reconstruction of the particle. Using cryo-electron microscopy it has become possible to generate reconstructions with sub-nanometer, near-atomic resolution resolution first in the case of highly symmetric viruses, and now in smaller, asymmetric proteins as well. == Techniques == Single particle analysis can be done on both negatively stained and vitreous ice-embedded transmission electron cryomicroscopy (CryoTEM) samples. Single particle analysis methods are, in general, reliant on the sample being homogeneous, although techniques for dealing with conformational heterogeneity are being developed. Images (micrographs) are taken with an electron microscope using charged-coupled device (CCD) detectors coupled to a phosphorescent layer (in the past, they were instead collected on film and digitized using high-quality scanners). The image processing is carried out using specialized software programs, often run on multi-processor computer clusters. Depending on the sample or the desired results, various steps of two- or three-dimensional processing can be done. === Alignment and classification === Biological samples, and especially samples embedded in thin vitreous ice, are highly radiation sensitive, thus only low electron doses can be used to image the sample. This low dose, as well as variations in the metal stain used (if used) means images have high noise relative to the signal given by the particle being observed. By aligning several similar images to each other so they are in register and then averaging them, an image with higher signal-to-noise ratio can be obtained. As the noise is mostly randomly distributed and the underlying image features constant, by averaging the intensity of each pixel over several images only the constant features are reinforced. Typically, the optimal alignment (a translation and an in-plane rotation) to map one image onto another is calculated by cross-correlation. However, a micrograph often contains particles in multiple different orientations and/or conformations, and so to get more representative image averages, a method is required to group similar particle images together into multiple sets. This is normally carried out using one of several data analysis and image classification algorithms, such as multi-variate statistical analysis and hierarchical ascendant classification, or k-means clustering. Often data sets of tens of thousands of particle images are used, and to reach an optimal solution an iterative procedure of alignment and classification is used, whereby strong image averages produced by classification are used as reference images for a subsequent alignment of the whole data set. === Image filtering === Image filtering (band-pass filtering) is often used to reduce the influence of high and/or low spatial frequency information in the images, which can affect the results of the alignment and classification procedures. This is particularly useful in negative stain images. The algorithms make use of fast Fourier transforms (FFT), often employing Gaussian shaped soft-edged masks in reciprocal space to suppress certain frequency ranges. High-pass filters remove low spatial frequencies (such as ramp or gradient effects), leaving the higher frequencies intact. Low-pass filters remove high spatial frequency features and have a blurring effect on fine details. === Contrast transfer function === Due to the nature of image formation in the electron microscope, bright-field TEM images are obtained using significant underfocus. This, along with features inherent in the microscope's lens system, creates blurring of the collected images visible as a point spread function. The combined effects of the imaging conditions are known as the contrast transfer function (CTF), and can be approximated mathematically as a function in reciprocal space. Specialized image processing techniques such as phase flipping and amplitude correction / Wiener filtering can (at least partially) correct for the CTF, and allow high resolution reconstructions. === Three-dimensional reconstruction === Transmission electron microscopy images are projections of the object showing the distribution of density through the object, similar to medical X-rays. By making use of the projection-slice theorem a three-dimensional reconstruction of the object can be generated by combining many images (2D projections) of the object taken from a range of viewing angles. Proteins in vitreous ice ideally adopt a random distribution of orientations (or viewing angles), allowing a fairly isotropic reconstruction if a large number of particle images are used. This contrasts with electron tomography, where the viewing angles are limited due to the geometry of the sample/imaging set up, giving an anisotropic reconstruction. Filtered back projection is a commonly used method of generating 3D reconstructions in single particle analysis, although many alternative algorithms exist. Before a reconstruction can be made, the orientation of the object in each image needs to be estimated. Several methods have been developed to work out the relative Euler angles of each image. Some are based on common lines (common 1D projections and sinograms), others use iterative projection matching algorithms. The latter works by beginning with a simple, low resolution 3D starting model and compares the experimental images to projections of the model and creates a new 3D to bootstrap towards a solution. Methods are also available for making 3D reconstructions of helical samples (such as tobacco mosaic virus), taking advantage of the inherent helical symmetry. Both real space methods (treating sections of the helix as single particles) and reciprocal space methods (using diffraction patterns) can be used for these samples. === Tilt methods === The specimen stage of the microscope can be tilted (typically along a single axis), allowing the single particle technique known as random conical tilt. An area of the specimen is imaged at both zero and at high angle (~60-70 degrees) tilts, or in the case of the related method of orthogonal tilt reconstruction, +45 and −45 degrees. Pairs of particles corresponding to the same object at two different tilts (tilt pairs) are selected, and by following the parameters used in subsequent alignment and classification steps a three-dimensional reconstruction can be generated relatively easily. This is because the viewing angle (defined as three Euler angles) of each particle is known from the tilt geometry. 3D reconstructions from random conical tilt suffer from missing information resulting from a restricted range of orientations. Known as the missing cone (due to the shape in reciprocal space), this causes distortions in the 3D maps. However, the missing cone problem can often be overcome by combining several tilt reconstructions. Tilt methods are best suited to negatively stained samples, and can be used for particles that adsorb to the carbon support film in preferred orientations. The phenomenon known as charging or beam-induced movement makes collecting high-tilt images of samples in vitreous ice challenging. === Map visualization and fitting === Various software programs are available that allow viewing the 3D maps. These often enable the user to manually dock in protein coordinates (structures from X-ray crystallography, NMR, or a computational model such as one found in the AlphaFold Protein Structure Database) of subunits into the electron density. Several programs can also fit subunits computationally; as of the 2020s using these programs tend to produce better accuracy than manual docking because they can perform labor-intensive tasks such as: The scale of SPA-derived maps depends on knowing the pixel size (angstorms per pixel), which is not always accurate. Programs can automatically correct for this difference by using coordinate data or by using knowledge of chemical bonds. Many proteins are made up of several roughly rigid protein domains linked by flexible parts. Pre-existing coordinate data, whether experimental or computational, may not exactly match the inter-domain positioning of the cyro-EM map. Modern programs can automatically "chop" pre-existing coordinate data into individual domains and fit them in individually. For higher-resolution structures, it is pos
SDL plc
SDL plc was a British multinational professional services company based in Maidenhead, Berkshire, United Kingdom. SDL specialized in language translation software and services (including interpretation services). It was listed on the London Stock Exchange until it was acquired by RWS Group in November 2020. == Name == SDL is an abbreviation for "Software and Documentation Localization". == History == The company was founded by Mark Lancaster with nine employees in 1992. It opened its first overseas office in France in 1996 and was first listed on the London Stock Exchange in 1999. The company grew organically and via acquisitions. SDL acquired Polylang Multimedia in 1998, International Translation & Publishing (ITP) in 2000, Alpnet in 2001, and the machine translation (MT) assets of Transparent Language in 2001. It bought Trados, a rival translation memory (TM) developer, in 2005. In 2007, the company acquired Tridion, a content management system vendor, and PASS Engineering, developers of the Passolo software. In 2008, it bought Idiom Technologies, a global information system management business. In July 2009 SDL acquired XyEnterprise in an all-cash transaction to add XML Professional Publisher as well as Contenta content management software and LiveContent to manage and deliver XML. This unit combined with Trisoft formerly Infoshare. In December 2009, SDL acquired Fredhopper, a Dutch eCommerce onsite search and navigation, onsite targeting and targeted advertising software vendor. Later that same year, it bought Xopus, another Dutch company and the leader in online XML editing. In May 2011 SDL acquired Dutch-based Media Asset Management company, Calamares, in 2012 the campaign management and social media analytics company, Alterian, and in 2013, bemoko, a supplier of internet software for mobile devices. In January 2016, having undertaken a strategic review, SDL announced the divestment of Fredhopper and Alterian as non-complementary to its new strategy. In August 2020 RWS Group announced a proposed takeover of the company for £809 million. The transaction was completed on 4 November 2020. == Operations == SDL provided software for language translation purposes.