Prism is a multi-format video converter developed by NCH Software for Windows and Mac OS. It offers converting tools for instant media conversions. Prism Video Converter can handle large and high-quality resolution media files. It provides built-in compressor and adjuster settings, allowing users to customize and optimize their videos according to their needs. The software also includes features such as previewing videos and adding effects. Prism offers a free version for non-commercial use as well as a premium version. == Features == Prism Video File Converter supports a wide range of file formats. It enables users to convert videos into formats like AVI, ASF, WMV, MP4, 3GP, etc. It offers the ability to convert DVDs into various formats. It provides tools for adjusting colour and filter options. Prism Video File Converter provides several customizable options for tweaking the output files during the conversion process. Users can adjust compression/encoder rates, set the resolution and frame rate, and specify the desired output file size. The software also offers various effects like video rotation, captions, watermarks, and text overlay. It also includes a built-in preview feature, that enables users to view their videos before and after the conversion process. It supports batch conversion and running conversion in background. == Controversy == Previously, Prism and certain other NCH Software products were bundled with optional browser plugins, including the Google Chrome toolbar and the Conduit toolbar. This resulted in user complaints and raised concerns from antivirus software companies like Norton and McAfee, which flagged them as potential malware. NCH Software has since removed all toolbars, browsers, and third-party app offerings in all Prism versions.
Meta-learning (computer science)
Meta-learning is a subfield of machine learning where automatic learning algorithms are applied to metadata about machine learning experiments. As of 2017, the term had not found a standard interpretation, however the main goal is to use such metadata to understand how automatic learning can become flexible in solving learning problems, hence to improve the performance of existing learning algorithms or to learn (induce) the learning algorithm itself, hence the alternative term learning to learn. Flexibility is important because each learning algorithm is based on a set of assumptions about the data, its inductive bias. This means that it will only learn well if the bias matches the learning problem. A learning algorithm may perform very well in one domain, but not on the next. This poses strong restrictions on the use of machine learning or data mining techniques, since the relationship between the learning problem (often some kind of database) and the effectiveness of different learning algorithms is not yet understood. By using different kinds of metadata, like properties of the learning problem, algorithm properties (like performance measures), or patterns previously derived from the data, it is possible to learn, select, alter or combine different learning algorithms to effectively solve a given learning problem. Critiques of meta-learning approaches bear a strong resemblance to the critique of metaheuristic, a possibly related problem. A good analogy to meta-learning, and the inspiration for Jürgen Schmidhuber's early work (1987) and Yoshua Bengio et al.'s work (1991), considers that genetic evolution learns the learning procedure encoded in genes and executed in each individual's brain. In an open-ended hierarchical meta-learning system using genetic programming, better evolutionary methods can be learned by meta evolution, which itself can be improved by meta meta evolution, etc. == Definition == A proposed definition for a meta-learning system combines three requirements: The system must include a learning subsystem. Experience is gained by exploiting meta knowledge extracted in a previous learning episode on a single dataset, or from different domains. Learning bias must be chosen dynamically. Bias refers to the assumptions that influence the choice of explanatory hypotheses and not the notion of bias represented in the bias-variance dilemma. Meta-learning is concerned with two aspects of learning bias. Declarative bias specifies the representation of the space of hypotheses, and affects the size of the search space (e.g., represent hypotheses using linear functions only). Procedural bias imposes constraints on the ordering of the inductive hypotheses (e.g., preferring smaller hypotheses). == Common approaches == There are three common approaches: using (cyclic) networks with external or internal memory (model-based) learning effective distance metrics (metrics-based) explicitly optimizing model parameters for fast learning (optimization-based). === Model-Based === Model-based meta-learning models updates its parameters rapidly with a few training steps, which can be achieved by its internal architecture or controlled by another meta-learner model. ==== Memory-Augmented Neural Networks ==== A Memory-Augmented Neural Network, or MANN for short, is claimed to be able to encode new information quickly and thus to adapt to new tasks after only a few examples. ==== Meta Networks ==== Meta Networks (MetaNet) learns a meta-level knowledge across tasks and shifts its inductive biases via fast parameterization for rapid generalization. === Metric-Based === The core idea in metric-based meta-learning is similar to nearest neighbors algorithms, which weight is generated by a kernel function. It aims to learn a metric or distance function over objects. The notion of a good metric is problem-dependent. It should represent the relationship between inputs in the task space and facilitate problem solving. ==== Convolutional Siamese Neural Network ==== Siamese neural network is composed of two twin networks whose output is jointly trained. There is a function above to learn the relationship between input data sample pairs. The two networks are the same, sharing the same weight and network parameters. ==== Matching Networks ==== Matching Networks learn a network that maps a small labelled support set and an unlabelled example to its label, obviating the need for fine-tuning to adapt to new class types. ==== Relation Network ==== The Relation Network (RN), is trained end-to-end from scratch. During meta-learning, it learns to learn a deep distance metric to compare a small number of images within episodes, each of which is designed to simulate the few-shot setting. ==== Prototypical Networks ==== Prototypical Networks learn a metric space in which classification can be performed by computing distances to prototype representations of each class. Compared to recent approaches for few-shot learning, they reflect a simpler inductive bias that is beneficial in this limited-data regime, and achieve satisfied results. === Optimization-Based === What optimization-based meta-learning algorithms intend for is to adjust the optimization algorithm so that the model can be good at learning with a few examples. ==== LSTM Meta-Learner ==== LSTM-based meta-learner is to learn the exact optimization algorithm used to train another learner neural network classifier in the few-shot regime. The parametrization allows it to learn appropriate parameter updates specifically for the scenario where a set amount of updates will be made, while also learning a general initialization of the learner (classifier) network that allows for quick convergence of training. ==== Temporal Discreteness ==== Model-Agnostic Meta-Learning (MAML) is a fairly general optimization algorithm, compatible with any model that learns through gradient descent. ==== Reptile ==== Reptile is a remarkably simple meta-learning optimization algorithm, given that both of its components rely on meta-optimization through gradient descent and both are model-agnostic. == Examples == Some approaches which have been viewed as instances of meta-learning: Recurrent neural networks (RNNs) are universal computers. In 1993, Jürgen Schmidhuber showed how "self-referential" RNNs can in principle learn by backpropagation to run their own weight change algorithm, which may be quite different from backpropagation. In 2001, Sepp Hochreiter & A.S. Younger & P.R. Conwell built a successful supervised meta-learner based on Long short-term memory RNNs. It learned through backpropagation a learning algorithm for quadratic functions that is much faster than backpropagation. Researchers at Deepmind (Marcin Andrychowicz et al.) extended this approach to optimization in 2017. In the 1990s, Meta Reinforcement Learning or Meta RL was achieved in Schmidhuber's research group through self-modifying policies written in a universal programming language that contains special instructions for changing the policy itself. There is a single lifelong trial. The goal of the RL agent is to maximize reward. It learns to accelerate reward intake by continually improving its own learning algorithm which is part of the "self-referential" policy. An extreme type of Meta Reinforcement Learning is embodied by the Gödel machine, a theoretical construct which can inspect and modify any part of its own software which also contains a general theorem prover. It can achieve recursive self-improvement in a provably optimal way. Model-Agnostic Meta-Learning (MAML) was introduced in 2017 by Chelsea Finn et al. Given a sequence of tasks, the parameters of a given model are trained such that few iterations of gradient descent with few training data from a new task will lead to good generalization performance on that task. MAML "trains the model to be easy to fine-tune." MAML was successfully applied to few-shot image classification benchmarks and to policy-gradient-based reinforcement learning. Variational Bayes-Adaptive Deep RL (VariBAD) was introduced in 2019. While MAML is optimization-based, VariBAD is a model-based method for meta reinforcement learning, and leverages a variational autoencoder to capture the task information in an internal memory, thus conditioning its decision making on the task. When addressing a set of tasks, most meta learning approaches optimize the average score across all tasks. Hence, certain tasks may be sacrificed in favor of the average score, which is often unacceptable in real-world applications. By contrast, Robust Meta Reinforcement Learning (RoML) focuses on improving low-score tasks, increasing robustness to the selection of task. RoML works as a meta-algorithm, as it can be applied on top of other meta learning algorithms (such as MAML and VariBAD) to increase their robustness. It is applicable to both supervised meta learning and meta reinforcement learning. Discovering meta-knowledge works by inducing knowledge
Alberto Broggi
Alberto Broggi is General Manager at VisLab srl (spinoff of the University of Parma acquired by Silicon-Valley company Ambarella Inc. in June 2015) and a professor of Computer Engineering at the University of Parma in Italy. == Research in computer vision, hardware, and AV == Broggi's research activities started in 1991–1994. His group together with the Dipartimento di Elettronica, Politecnico di Torino, Italy, built their own hardware architecture (named PAPRICA, for PArallel PRocessor for Image Checking and Analysis, based on 256 single-bit processing elements working in SIMD fashion) and installed it on board of a mobile laboratory (Mob-Lab) to develop and test some initial concepts in the field of intelligent vehicles. In 1996, Broggi's group worked to develop a real vehicle prototype (named ARGO, a Lancia Thema passenger car which was equipped with vision sensors, processing systems, and vehicle actuators) and developed the necessary software and hardware that made it able to drive autonomously on standard roads. Broggi's research group (called VisLab from then on) gathered all their findings in a book, which was then also translated in Chinese. When Broggi was with the University of Pavia, his research was extended and applied to extreme conditions (automatic driving on snow and ice): in 2001, VisLab led the research effort of providing a vehicle (RAS, Robot Antartico di Superficie) with sensing capabilities so that it was able to automatically follow the vehicle in front. In 2010 Broggi's group embarked on driving 4 vehicles autonomously from Italy to China with no human intervention. This challenge is called VIAC, for VisLab Intercontinental Autonomous Challenge . Soon after this, Broggi was awarded a second ERC grant (Proof of concept) to industrialize some of the results obtained and successfully tested on the VIAC vehicles. On July 12, 2013, VisLab tested the BRAiVE vehicle in downtown Parma, negotiating two-way narrow rural roads, pedestrian crossings, traffic lights, artificial bumps, pedestrian areas, and tight roundabouts. The vehicle traveled from Parma University Campus up to Piazza della Pilotta (downtown Parma): a 20 minutes run in a real environment, together with real traffic at 11am on a working day, that required absolutely no human intervention. Part of this test was driven with nobody in the driver seat, for the first time ever on public roads.
Robert Wilensky
Robert Wilensky (26 March 1951 – 15 March 2013) was an American computer scientist and professor at the UC Berkeley School of Information, with his main focus of research in artificial intelligence. == Academic career == In 1971, Wilensky received his bachelor's degree in mathematics from Yale University, and in 1978, a Ph.D. in computer science from the same institution. After finishing his thesis, "Understanding Goal-Based Stories", Wilensky joined the faculty from the EECS Department of UC Berkeley. In 1986, he worked as the doctoral advisor of Peter Norvig, who then later published the standard textbook of the field: Artificial Intelligence: A Modern Approach. From 1993 to 1997, Wilensky was the Berkeley Computer Science Division Chair. During this time, he also served as director of the Berkeley Cognitive Science Program, director of the Berkeley Artificial Intelligence Research Project, and board member of the International Computer Science Institute. In 1997, he became a fellow of the Association for Computing Machinery "for research contributions to the areas of natural language processing and digital libraries as well as outstanding leadership in Computer Science." Furthermore, he also was a Fellow of the Association for the Advancement of Artificial Intelligence. He retired from faculty in 2007 and died on Friday, March 15, 2013, of a bacterial infection at the Alta Bates Summit Medical Center. Wilensky was married to Ann Danforth and he is survived by her and their two children, Avi and Eli Wilensky == Research == Throughout his career, Wilensky authored and co-authored over 60 scholarly articles and technical reports on AI, natural language processing, and information dissemination. In addition to his numerous technical publications, Wilensky also published two books on the programming language LISP, LISPcraft and Common LISPcraft, and had almost completed another book manuscript when he suffered a cardiac arrest and stopped writing. Among his publications are: R. Wilensky, (1986-09-17). Common LISPcraft. W. W. Norton & Company. ISBN 9780393955446. T. A. Phelps and R. Wilensky, "Toward active, extensible, networked documents: Multivalent architecture and applications," in Proc. 1st ACM Intl. Conf. on Digital Libraries, E. A. Fox and G. Marchionini, Eds., New York, NY: ACM Press, 1996, pp. 100–108. J. Traupman and R. Wilensky, "Experiments in Improving Unsupervised Word Sense Disambiguation," University of California, Berkeley, Department of EECS, Computer Science Division, Tech. Rep. 03–1227, Feb. 2003. R. Wilensky, Planning and Understanding: A Computational Approach to Human Reasoning, Advanced Book Program, Reading, MA: Addison-Wesley Publishing Co., 1983. R. Wilensky, "Understanding Goal-Based Stories," Yale University, Sep. 1978. B. Kahn and R. Wilensky, "A Framework for Distributed Digital Object Services", May 1995.
Jürgen Schmidhuber
Jürgen Schmidhuber (born 17 January 1963) is a German computer scientist noted for his work in the field of artificial intelligence, specifically artificial neural networks. He has been described by media outlets as a leading pioneer of modern artificial intelligence. He is a scientific director of the Dalle Molle Institute for Artificial Intelligence Research in Switzerland. He is also director of the Artificial Intelligence Initiative and professor of the Computer Science program in the Computer, Electrical, and Mathematical Sciences and Engineering (CEMSE) division at the King Abdullah University of Science and Technology (KAUST) in Saudi Arabia. He is best known for his work on long short-term memory (LSTM), a type of neural network architecture which was the dominant technique for various natural language processing tasks in research and commercial applications in the 2010s. He also introduced principles of dynamic neural networks, meta-learning, generative adversarial networks and linear transformers, all of which are widespread in modern AI. == Career == Schmidhuber completed his undergraduate (1987) and PhD (1991) studies at the Technical University of Munich in Munich, Germany. His PhD advisors were Wilfried Brauer and Klaus Schulten. He taught there from 2004 until 2009. From 2009 to 2021, he was a professor of artificial intelligence at the Università della Svizzera Italiana in Lugano, Switzerland. He has served as the director of Dalle Molle Institute for Artificial Intelligence Research (IDSIA), a Swiss AI lab, since 1995. Since 2021, he has also been the director of the AI Initiative at the King Abdullah University of Science and Technology (KAUST). In 2014, Schmidhuber formed a company, NNAISENSE, to work on commercial applications of artificial intelligence in fields such as finance, heavy industry and self-driving cars. Sepp Hochreiter, Jaan Tallinn, and Marcus Hutter are advisers to the company. Sales were under US$11 million in 2016; however, Schmidhuber states that the current emphasis is on research and not revenue. NNAISENSE raised its first round of capital funding in January 2017. Schmidhuber's overall goal is to create an all-purpose AI by training a single AI in sequence on a variety of narrow tasks, but as of 2026 he has said that the focus of NNAISENSE has shifted from artificial general intelligence to asset management. == Research == In the 1980s, backpropagation did not work well for deep learning with long credit assignment paths in artificial neural networks. To overcome this problem, Schmidhuber (1991) proposed a hierarchy of recurrent neural networks (RNNs) pre-trained one level at a time by self-supervised learning. It uses predictive coding to learn internal representations at multiple self-organizing time scales, facilitating downstream deep learning. The RNN hierarchy can be collapsed into a single RNN, by distilling a higher level chunker network into a lower level automatizer network. In 1993, a chunker solved a deep learning task whose depth exceeded 1000. In 1991, Schmidhuber published adversarial neural networks that contest with each other in the form of a zero-sum game, where one network's gain is the other network's loss. The first network is a generative model that models a probability distribution over output patterns. The second network learns by gradient descent to predict the reactions of the environment to these patterns. This was called "artificial curiosity". In 2014, this principle was used in the creation of the generative adversarial network, which Schmidhuber describes as a special case of artificial curiosity where the environmental reaction is 1 or 0 depending on whether the first network's output is in a given set. Schmidhuber supervised the 1991 diploma thesis of his student Sepp Hochreiter which he considered "one of the most important documents in the history of machine learning". It studied the neural history compressor and analyzed and overcame the vanishing gradient problem. This led to the creation of long short-term memory (LSTM), a type of recurrent neural network. The name LSTM was introduced in a tech report in 1995, leading to the most cited LSTM publication, published in 1997 and co-authored by Hochreiter and Schmidhuber. The standard LSTM architecture was introduced in 2000 by Felix Gers, Schmidhuber, and Fred Cummins. Today's "vanilla LSTM" using backpropagation through time was published with his student Alex Graves in 2005, and its connectionist temporal classification (CTC) training algorithm in 2006. CTC was applied to end-to-end speech recognition with LSTM. In 2014, the state of the art was training “very deep neural network” with 20 to 30 layers. Stacking too many layers led to a steep reduction in training accuracy, known as the "degradation" problem. In May 2015, Rupesh Kumar Srivastava, Klaus Greff, and Schmidhuber used LSTM principles to create the highway network, a feedforward neural network with hundreds of layers, much deeper than previous networks. In Dec 2015, the residual neural network (ResNet) was published, which is a variant of the highway network. In 1992, Schmidhuber published fast weights programmer, an alternative to recurrent neural networks. It has a slow feedforward neural network that learns by gradient descent to control the fast weights of another neural network through outer products of self-generated activation patterns, and the fast weights network itself operates over inputs. This was later shown to be equivalent to the unnormalized linear transformer. In 2011, Schmidhuber's team at IDSIA with his postdoc Dan Ciresan also achieved dramatic speedups of convolutional neural networks (CNNs) using graphics processing units (GPUs), based on CNN designs introduced much earlier by Kunihiko Fukushima. An earlier CNN on GPU by Chellapilla et al. (2006) was 4 times faster than an equivalent implementation on CPU. The deep CNN of Dan Ciresan et al. (2011) at IDSIA was 60 times faster and achieved the first superhuman performance in a computer vision contest in August 2011. Between 15 May 2011 and 10 September 2012, these CNNs won four more image competitions and improved the state of the art on multiple image benchmarks. The approach has become central to the field of computer vision. == Credit disputes == Schmidhuber has controversially argued that he and other researchers have been denied adequate recognition for their contribution to the field of deep learning, in favour of Geoffrey Hinton, Yoshua Bengio and Yann LeCun, who shared the 2018 Turing Award for their work in deep learning. He wrote a "scathing" 2015 article arguing that Hinton, Bengio and LeCun "heavily cite each other" but "fail to credit the pioneers of the field". In a statement to the New York Times, Yann LeCun wrote that "Jürgen is manically obsessed with recognition and keeps claiming credit he doesn't deserve for many, many things... It causes him to systematically stand up at the end of every talk and claim credit for what was just presented, generally not in a justified manner." Schmidhuber replied that LeCun did this "without any justification, without providing a single example", and published details of numerous priority disputes with Hinton, Bengio and LeCun. The term "schmidhubered" has been jokingly used in the AI community to describe Schmidhuber's habit of publicly challenging the originality of other researchers' work, a practice seen by some in the AI community as a "rite of passage" for young researchers. Some suggest that Schmidhuber's significant accomplishments have been underappreciated due to his confrontational personality. == Recognition == Schmidhuber received the Helmholtz Award of the International Neural Network Society in 2013, and the Neural Networks Pioneer Award of the IEEE Computational Intelligence Society in 2016 for "pioneering contributions to deep learning and neural networks." He is a member of the European Academy of Sciences and Arts. He has been referred to as the "father of modern AI", the "father of generative AI", and the "father of deep learning". Schmidhuber himself, however, has called Alexey Grigorevich Ivakhnenko the "father of deep learning", and gives credit to many even earlier AI pioneers. The New York Times ran a profile under the headline "When A.I. Matures, It May Call Jürgen Schmidhuber 'Dad'", highlighting his early work on deep learning and his long‑term vision for self‑improving AI. == Views == Schmidhuber is a proponent of open source AI, and believes that they will become competitive against commercial closed-source AI. Since the 1970s, Schmidhuber wanted to create "intelligent machines that could learn and improve on their own and become smarter than him within his lifetime." He differentiates between two types of AIs: tool AI, such as those for improving healthcare, and autonomous AIs that set their own goals, perform their own research, and explore the universe. He has worked on both types for de
Instance-based learning
In machine learning, instance-based learning (sometimes called memory-based learning) is a family of learning algorithms that, instead of performing explicit generalization, compare new problem instances with instances seen in training, which have been stored in memory. Because computation is postponed until a new instance is observed, these algorithms are sometimes referred to as "lazy." It is called instance-based because it constructs hypotheses directly from the training instances themselves. This means that the hypothesis complexity can grow with the data: in the worst case, a hypothesis is a list of n training items and the computational complexity of classifying a single new instance is O(n). One advantage that instance-based learning has over other methods of machine learning is its ability to adapt its model to previously unseen data. Instance-based learners may simply store a new instance or throw an old instance away. Examples of instance-based learning algorithms are the k-nearest neighbors algorithm, kernel machines and RBF networks. These store (a subset of) their training set; when predicting a value/class for a new instance, they compute distances or similarities between this instance and the training instances to make a decision. To battle the memory complexity of storing all training instances, as well as the risk of overfitting to noise in the training set, instance reduction algorithms have been proposed.
GLIMMER
In bioinformatics, GLIMMER (Gene Locator and Interpolated Markov ModelER) is used to find genes in prokaryotic DNA. "It is effective at finding genes in bacteria, archea, viruses, typically finding 98-99% of all relatively long protein coding genes". GLIMMER was the first system that used the interpolated Markov model to identify coding regions. The GLIMMER software is open source and is maintained by Steven Salzberg, Art Delcher, and their colleagues at the Center for Computational Biology at Johns Hopkins University. The original GLIMMER algorithms and software were designed by Art Delcher, Simon Kasif and Steven Salzberg and applied to bacterial genome annotation in collaboration with Owen White. == Versions == === GLIMMER 1.0 === First Version of GLIMMER "i.e., GLIMMER 1.0" was released in 1998 and it was published in the paper Microbial gene identification using interpolated Markov model. Markov models were used to identify microbial genes in GLIMMER 1.0. GLIMMER considers the local composition sequence dependencies which makes GLIMMER more flexible and more powerful when compared to fixed-order Markov model. There was a comparison made between interpolated Markov model used by GLIMMER and fifth order Markov model in the paper Microbial gene identification using interpolated Markov models. "GLIMMER algorithm found 1680 genes out of 1717 annotated genes in Haemophilus influenzae where fifth order Markov model found 1574 genes. GLIMMER found 209 additional genes which were not included in 1717 annotated genes where fifth order Markov model found 104 genes."' === GLIMMER 2.0 === Second Version of GLIMMER i.e., GLIMMER 2.0 was released in 1999 and it was published in the paper Improved microbial identification with GLIMMER. This paper provides significant technical improvements such as using interpolated context model instead of interpolated Markov model and resolving overlapping genes which improves the accuracy of GLIMMER. Interpolated context models are used instead of interpolated Markov model which gives the flexibility to select any base. In interpolated Markov model probability distribution of a base is determined from the immediate preceding bases. If the immediate preceding base is irrelevant amino acid translation, interpolated Markov model still considers the preceding base to determine the probability of given base where as interpolated context model which was used in GLIMMER 2.0 can ignore irrelevant bases. False positive predictions were increased in GLIMMER 2.0 to reduce the number of false negative predictions. Overlapped genes are also resolved in GLIMMER 2.0. Various comparisons between GLIMMER 1.0 and GLIMMER 2.0 were made in the paper Improved microbial identification with GLIMMER which shows improvement in the later version. "Sensitivity of GLIMMER 1.0 ranges from 98.4 to 99.7% with an average of 99.1% where as GLIMMER 2.0 has a sensitivity range from 98.6 to 99.8% with an average of 99.3%. GLIMMER 2.0 is very effective in finding genes of high density. The parasite Trypanosoma brucei, responsible for causing African sleeping sickness is being identified by GLIMMER 2.0" === GLIMMER 3.0 === Third version of GLIMMER, "GLIMMER 3.0" was released in 2007 and it was published in the paper Identifying bacterial genes and endosymbiont DNA with Glimmer. This paper describes several major changes made to the GLIMMER system including improved methods to identify coding regions and start codon. Scoring of ORF in GLIMMER 3.0 is done in reverse order i.e., starting from stop codon and moves back towards the start codon. Reverse scanning helps in identifying the coding portion of the gene more accurately which is contained in the context window of IMM. GLIMMER 3.0 also improves the generated training set data by comparing the long-ORF with universal amino acid distribution of widely disparate bacterial genomes."GLIMMER 3.0 has an average long-ORF output of 57% for various organisms where as GLIMMER 2.0 has an average long-ORF output of 39%." GLIMMER 3.0 reduces the rate of false positive predictions which were increased in GLIMMER 2.0 to reduce the number of false negative predictions. "GLIMMER 3.0 has a start-site prediction accuracy of 99.5% for 3'5' matches where as GLIMMER 2.0 has 99.1% for 3'5' matches. GLIMMER 3.0 uses a new algorithm for scanning coding regions, a new start site detection module, and architecture which integrates all gene predictions across an entire genome." Minimum description length === Theoretical and Biological Foundation === The GLIMMER project helped introduce and popularize the use of variable length models in Computational Biology and Bioinformatics that subsequently have been applied to numerous problems such as protein classification and others. Variable length modeling was originally pioneered by information theorists and subsequently ingeniously applied and popularized in data compression (e.g. Ziv-Lempel compression). Prediction and compression are intimately linked using Minimum Description Length Principles. The basic idea is to create a dictionary of frequent words (motifs in biological sequences). The intuition is that the frequently occurring motifs are likely to be most predictive and informative. In GLIMMER the interpolated model is a mixture model of the probabilities of these relatively common motifs. Similarly to the development of HMMs in Computational Biology, the authors of GLIMMER were conceptually influenced by the previous application of another variant of interpolated Markov models to speech recognition by researchers such as Fred Jelinek (IBM) and Eric Ristad (Princeton). The learning algorithm in GLIMMER is different from these earlier approaches. == Access == GLIMMER can be downloaded from The Glimmer home page (requires a C++ compiler). Alternatively, an online version is hosted by NCBI [1]. == How it works == GLIMMER primarily searches for long-ORFS. An open reading frame might overlap with any other open reading frame which will be resolved using the technique described in the sub section. Using these long-ORFS and following certain amino acid distribution GLIMMER generates training set data. Using these training data, GLIMMER trains all the six Markov models of coding DNA from zero to eight order and also train the model for noncoding DNA GLIMMER tries to calculate the probabilities from the data. Based on the number of observations, GLIMMER determines whether to use fixed order Markov model or interpolated Markov model. If the number of observations are greater than 400, GLIMMER uses fixed order Markov model to obtain there probabilities. If the number of observations are less than 400, GLIMMER uses interpolated Markov model which is briefly explained in the next sub section. GLIMMER obtains score for every long-ORF generated using all the six coding DNA models and also using non-coding DNA model. If the score obtained in the previous step is greater than a certain threshold then GLIMMER predicts it to be a gene. The steps explained above describes the basic functionality of GLIMMER. There are various improvements made to GLIMMER and some of them are described in the following sub-sections. === The GLIMMER system === GLIMMER system consists of two programs. First program called build-imm, which takes an input set of sequences and outputs the interpolated Markov model as follows. The probability for each base i.e., A,C,G,T for all k-mers for 0 ≤ k ≤ 8 is computed. Then, for each k-mer, GLIMMER computes weight. New sequence probability is computed as follows. where n is the length of the sequence S x {\displaystyle S_{x}} is the oligomer at position x. I M M 8 ( S x ) {\displaystyle IMM_{8}(S_{x})} , the 8 t h {\displaystyle 8^{th}} -order interpolated Markov model score is computed as "where Y k ( S x − 1 ) {\displaystyle Y_{k}(S_{x-1})} is the weight of the k-mer at position x-1 in the sequence S and P k ( S x ) {\displaystyle P_{k}(S_{x})} is the estimate obtained from the training data of the probability of the base located at position x in the k t h {\displaystyle k^{th}} -order model." The probability of base S x {\displaystyle S_{x}} given the i previous bases is computed as follows. "The value of Y i ( S x ) {\displaystyle Y_{i}(S_{x})} associated with P i ( S x ) {\displaystyle P_{i}(S_{x})} can be regarded as a measure of confidence in the accuracy of this value as an estimate of the true probability. GLIMMER uses two criteria to determine Y i ( S x ) {\displaystyle Y_{i}(S_{x})} . The first of these is simple frequency occurrence in which the number of occurrences of context string S x , i {\displaystyle S_{x,i}} in the training data exceeds a specific threshold value, then Y i ( S x ) {\displaystyle Y_{i}(S_{x})} is set to 1.0. The current default value for threshold is 400, which gives 95% confidence. When there are insufficient sample occurrences of a context string, build-imm employ additional criteria to determine Y {\displaystyle Y} value. For a