Raster graphics editors can be compared by many variables, including availability. == List == == General information == Basic general information about the editor: creator, company, license, etc. == Operating system support == The operating systems on which the editors can run natively, that is, without emulation, virtual machines or compatibility layers. In other words, the software must be specifically coded for the operation system; for example, Adobe Photoshop for Windows running on Linux with Wine does not fit. == Features == == Color spaces == == File support ==
Backend as a service
Backend as a service (BaaS), sometimes also referred to as mobile backend as a service (MBaaS), is a service for providing web app and mobile app developers with a way to easily build a backend to their frontend applications. Features available include user management, push notifications, and integration with social networking services. These services are provided via the use of custom software development kits (SDKs) and application programming interfaces (APIs). BaaS is a relatively recent development in cloud computing, with most BaaS startups dating from 2011 or later. Some of the most popular service providers are AWS Amplify and Firebase. == Purpose == Web and mobile apps require a similar set of features on the backend, including notification service, integration with social networks, and cloud storage. Each of these services has its own API that must be individually incorporated into an app, a process that can be time-consuming and complicated for app developers. BaaS providers form a bridge between the frontend of an application and various cloud-based backends via a unified API and SDK. Providing a consistent way to manage backend data means that developers do not need to redevelop their own backend for each of the services that their apps need to access, potentially saving both time and money. Although similar to other cloud-computing business models, such as serverless computing, software as a service (SaaS), infrastructure as a service (IaaS), and platform as a service (PaaS), BaaS is distinct from these other services in that it specifically addresses the cloud-computing needs of web and mobile app developers by providing a unified means of connecting their apps to cloud services. == Features == BaaS providers offer different set of features and backend tools. Some of the most common features include: Database management. Most BaaS solutions provide SQL and/or NoSQL database management services for applications. Developers can store their app data without deploying and managing databases themselves. BaaS usually provides client SDKs, REST and GraphQL APIs for the frontend to interact with databases. File storage. BaaS providers often offer storage solutions for media files, user uploads, and other binary data. Applications can upload, download, and delete files through provided SDKs and APIs. Authentication and authorization. Some BaaS offer authentication and authorization services that allow developers to easily manage app users. This includes user sign-up, login, password reset, social media login integration through OAuth, user group and permission management etc. Notification service. Some BaaS providers such as Firebase and AWS Amplify have notification services that can send custom emails to users and push native notifications on mobile platforms. This is especially useful for applications that need to send messages, alerts, and reminders. Cloud functions. Some BaaS allow developers to deploy and run serverless functions. The functions are usually stateless and can be triggered by various ways including HTTP requests, SDK invocation, background server events, and cloud scheduled executions. Different providers offer runtime support for different languages, some of the popular languages are JavaScript/TypeScript (Node.js, Deno), Python, Java/Kotlin. Cloud functions extend the potential and flexibility of BaaS by allowing developers to write custom functionalities for their apps, working in a way similar to a traditional REST API backend framework. Usage analytics. Analytics data about application usage is often included in BaaS. This allows developers to monitor user behaviors and make decisions correspondingly in marketing strategies and performance optimizations. UI design. Some BaaS providers, such as AWS Amplify and Backendless, offer user interface designing tools that help developers design the frontend UI of web and mobile apps. While this may be useful for small teams and individual developers, UI design assistance may not be conventional in BaaS as it goes beyond the scope of backend infrastructure. Real-Time. Real-time features in a BaaS platform ensure that data updates and synchronizations occur instantly across all clients, making changes immediately visible to users. This is crucial for applications like live chat and collaborative tools, using technologies like WebSockets to maintain continuous server-client connections. == Service providers == BaaS providers have a broad focus, providing SDKs and APIs that work for app development on multiple platforms with different technology stacks, such as JavaScript (for Web apps), Flutter, Java/Kotlin (for Android apps), Swift/Objective-C (for iOS/MacOS/WatchOS/TvOS apps), .NET (for Windows) and others. BaaS providers also come in different types, suiting developers of different needs. === Cloud-based BaaS === Most BaaS providers host backend platforms on their cloud servers. They also manage the infrastructure, security, and scalability of the platforms. Developers can access the backend services via a web interface or the provided APIs. Some examples of cloud-based BaaS include Firebase (hosted on Google Cloud Platform), AWS Amplify (hosted on Amazon Web Services), and Microsoft Azure Mobile Apps (hosted on Microsoft Azure). === Self-hosted BaaS === Self-hosted BaaS allow developers to host backend on their own servers, providing more flexibility and potential to customization compared to cloud-based BaaS, which often is more difficult to migrate from. However, developers are also in charge of managing the infrastructure, security, and scalability of their servers. === Mobile BaaS === Mobile backend as a service (MBaaS) is a type of BaaS specifically for applications deployed in mobile systems. While some references use MBaaS interchangeably for BaaS, BaaS can have a wider variety of support such as for web apps and desktop apps. == Business model == BaaS providers generate revenue from their services in various ways, often using a freemium model. Under this model, a client receives a certain number of free active users or API calls per month, and pays a fee for each user or call over this limit. Alternatively, clients can pay a set fee for a package which allows for a greater number of calls or active users per month. There are also flat fee plans that make the pricing more predictable. Some of the providers offer the unlimited API calls inside their free plan offerings. Another business model that has been used by a lot of BaaS providers is PAYG (pay as you go), which has a flexible cost based on developers' usage of database, storage, bandwidth, function calls, user numbers etc.
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GLIMMER
In bioinformatics, GLIMMER (Gene Locator and Interpolated Markov ModelER) is used to find genes in prokaryotic DNA. "It is effective at finding genes in bacteria, archea, viruses, typically finding 98-99% of all relatively long protein coding genes". GLIMMER was the first system that used the interpolated Markov model to identify coding regions. The GLIMMER software is open source and is maintained by Steven Salzberg, Art Delcher, and their colleagues at the Center for Computational Biology at Johns Hopkins University. The original GLIMMER algorithms and software were designed by Art Delcher, Simon Kasif and Steven Salzberg and applied to bacterial genome annotation in collaboration with Owen White. == Versions == === GLIMMER 1.0 === First Version of GLIMMER "i.e., GLIMMER 1.0" was released in 1998 and it was published in the paper Microbial gene identification using interpolated Markov model. Markov models were used to identify microbial genes in GLIMMER 1.0. GLIMMER considers the local composition sequence dependencies which makes GLIMMER more flexible and more powerful when compared to fixed-order Markov model. There was a comparison made between interpolated Markov model used by GLIMMER and fifth order Markov model in the paper Microbial gene identification using interpolated Markov models. "GLIMMER algorithm found 1680 genes out of 1717 annotated genes in Haemophilus influenzae where fifth order Markov model found 1574 genes. GLIMMER found 209 additional genes which were not included in 1717 annotated genes where fifth order Markov model found 104 genes."' === GLIMMER 2.0 === Second Version of GLIMMER i.e., GLIMMER 2.0 was released in 1999 and it was published in the paper Improved microbial identification with GLIMMER. This paper provides significant technical improvements such as using interpolated context model instead of interpolated Markov model and resolving overlapping genes which improves the accuracy of GLIMMER. Interpolated context models are used instead of interpolated Markov model which gives the flexibility to select any base. In interpolated Markov model probability distribution of a base is determined from the immediate preceding bases. If the immediate preceding base is irrelevant amino acid translation, interpolated Markov model still considers the preceding base to determine the probability of given base where as interpolated context model which was used in GLIMMER 2.0 can ignore irrelevant bases. False positive predictions were increased in GLIMMER 2.0 to reduce the number of false negative predictions. Overlapped genes are also resolved in GLIMMER 2.0. Various comparisons between GLIMMER 1.0 and GLIMMER 2.0 were made in the paper Improved microbial identification with GLIMMER which shows improvement in the later version. "Sensitivity of GLIMMER 1.0 ranges from 98.4 to 99.7% with an average of 99.1% where as GLIMMER 2.0 has a sensitivity range from 98.6 to 99.8% with an average of 99.3%. GLIMMER 2.0 is very effective in finding genes of high density. The parasite Trypanosoma brucei, responsible for causing African sleeping sickness is being identified by GLIMMER 2.0" === GLIMMER 3.0 === Third version of GLIMMER, "GLIMMER 3.0" was released in 2007 and it was published in the paper Identifying bacterial genes and endosymbiont DNA with Glimmer. This paper describes several major changes made to the GLIMMER system including improved methods to identify coding regions and start codon. Scoring of ORF in GLIMMER 3.0 is done in reverse order i.e., starting from stop codon and moves back towards the start codon. Reverse scanning helps in identifying the coding portion of the gene more accurately which is contained in the context window of IMM. GLIMMER 3.0 also improves the generated training set data by comparing the long-ORF with universal amino acid distribution of widely disparate bacterial genomes."GLIMMER 3.0 has an average long-ORF output of 57% for various organisms where as GLIMMER 2.0 has an average long-ORF output of 39%." GLIMMER 3.0 reduces the rate of false positive predictions which were increased in GLIMMER 2.0 to reduce the number of false negative predictions. "GLIMMER 3.0 has a start-site prediction accuracy of 99.5% for 3'5' matches where as GLIMMER 2.0 has 99.1% for 3'5' matches. GLIMMER 3.0 uses a new algorithm for scanning coding regions, a new start site detection module, and architecture which integrates all gene predictions across an entire genome." Minimum description length === Theoretical and Biological Foundation === The GLIMMER project helped introduce and popularize the use of variable length models in Computational Biology and Bioinformatics that subsequently have been applied to numerous problems such as protein classification and others. Variable length modeling was originally pioneered by information theorists and subsequently ingeniously applied and popularized in data compression (e.g. Ziv-Lempel compression). Prediction and compression are intimately linked using Minimum Description Length Principles. The basic idea is to create a dictionary of frequent words (motifs in biological sequences). The intuition is that the frequently occurring motifs are likely to be most predictive and informative. In GLIMMER the interpolated model is a mixture model of the probabilities of these relatively common motifs. Similarly to the development of HMMs in Computational Biology, the authors of GLIMMER were conceptually influenced by the previous application of another variant of interpolated Markov models to speech recognition by researchers such as Fred Jelinek (IBM) and Eric Ristad (Princeton). The learning algorithm in GLIMMER is different from these earlier approaches. == Access == GLIMMER can be downloaded from The Glimmer home page (requires a C++ compiler). Alternatively, an online version is hosted by NCBI [1]. == How it works == GLIMMER primarily searches for long-ORFS. An open reading frame might overlap with any other open reading frame which will be resolved using the technique described in the sub section. Using these long-ORFS and following certain amino acid distribution GLIMMER generates training set data. Using these training data, GLIMMER trains all the six Markov models of coding DNA from zero to eight order and also train the model for noncoding DNA GLIMMER tries to calculate the probabilities from the data. Based on the number of observations, GLIMMER determines whether to use fixed order Markov model or interpolated Markov model. If the number of observations are greater than 400, GLIMMER uses fixed order Markov model to obtain there probabilities. If the number of observations are less than 400, GLIMMER uses interpolated Markov model which is briefly explained in the next sub section. GLIMMER obtains score for every long-ORF generated using all the six coding DNA models and also using non-coding DNA model. If the score obtained in the previous step is greater than a certain threshold then GLIMMER predicts it to be a gene. The steps explained above describes the basic functionality of GLIMMER. There are various improvements made to GLIMMER and some of them are described in the following sub-sections. === The GLIMMER system === GLIMMER system consists of two programs. First program called build-imm, which takes an input set of sequences and outputs the interpolated Markov model as follows. The probability for each base i.e., A,C,G,T for all k-mers for 0 ≤ k ≤ 8 is computed. Then, for each k-mer, GLIMMER computes weight. New sequence probability is computed as follows. where n is the length of the sequence S x {\displaystyle S_{x}} is the oligomer at position x. I M M 8 ( S x ) {\displaystyle IMM_{8}(S_{x})} , the 8 t h {\displaystyle 8^{th}} -order interpolated Markov model score is computed as "where Y k ( S x − 1 ) {\displaystyle Y_{k}(S_{x-1})} is the weight of the k-mer at position x-1 in the sequence S and P k ( S x ) {\displaystyle P_{k}(S_{x})} is the estimate obtained from the training data of the probability of the base located at position x in the k t h {\displaystyle k^{th}} -order model." The probability of base S x {\displaystyle S_{x}} given the i previous bases is computed as follows. "The value of Y i ( S x ) {\displaystyle Y_{i}(S_{x})} associated with P i ( S x ) {\displaystyle P_{i}(S_{x})} can be regarded as a measure of confidence in the accuracy of this value as an estimate of the true probability. GLIMMER uses two criteria to determine Y i ( S x ) {\displaystyle Y_{i}(S_{x})} . The first of these is simple frequency occurrence in which the number of occurrences of context string S x , i {\displaystyle S_{x,i}} in the training data exceeds a specific threshold value, then Y i ( S x ) {\displaystyle Y_{i}(S_{x})} is set to 1.0. The current default value for threshold is 400, which gives 95% confidence. When there are insufficient sample occurrences of a context string, build-imm employ additional criteria to determine Y {\displaystyle Y} value. For a
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Shape factor (image analysis and microscopy)
Shape factors are dimensionless quantities used in image analysis and microscopy that numerically describe the shape of a particle, independent of its size. Shape factors are calculated from measured dimensions, such as diameter, chord lengths, area, perimeter, centroid, moments, etc. The dimensions of the particles are usually measured from two-dimensional cross-sections or projections, as in a microscope field, but shape factors also apply to three-dimensional objects. The particles could be the grains in a metallurgical or ceramic microstructure, or the microorganisms in a culture, for example. The dimensionless quantities often represent the degree of deviation from an ideal shape, such as a circle, sphere or equilateral polyhedron. Shape factors are often normalized, that is, the value ranges from zero to one. A shape factor equal to one usually represents an ideal case or maximum symmetry, such as a circle, sphere, square or cube. == Aspect ratio == The most common shape factor is the aspect ratio, a function of the largest diameter and the smallest diameter orthogonal to it: A R = d min d max {\displaystyle A_{R}={\frac {d_{\min }}{d_{\max }}}} The normalized aspect ratio varies from approaching zero for a very elongated particle, such as a grain in a cold-worked metal, to near unity for an equiaxed grain. The reciprocal of the right side of the above equation is also used, such that the AR varies from one to approaching infinity. == Circularity == Another very common shape factor is the circularity (or isoperimetric quotient), a function of the perimeter P and the area A: f circ = 4 π A P 2 {\displaystyle f_{\text{circ}}={\frac {4\pi A}{P^{2}}}} The circularity of a circle is 1, and much less than one for a starfish footprint. The reciprocal of the circularity equation is also used, such that fcirc varies from one for a circle to infinity. == Elongation shape factor == The less-common elongation shape factor is defined as the square root of the ratio of the two second moments in of the particle around its principal axes. f elong = i 2 i 1 {\displaystyle f_{\text{elong}}={\sqrt {\frac {i_{2}}{i_{1}}}}} == Compactness shape factor == The compactness shape factor is a function of the polar second moment in of a particle and a circle of equal area A. f comp = A 2 2 π i 1 2 + i 2 2 {\displaystyle f_{\text{comp}}={\frac {A^{2}}{2\pi {\sqrt {{i_{1}}^{2}+{i_{2}}^{2}}}}}} The fcomp of a circle is one, and much less than one for the cross-section of an I-beam. == Waviness shape factor == The waviness shape factor of the perimeter is a function of the convex portion Pcvx of the perimeter to the total. f wav = P cvx P {\displaystyle f_{\text{wav}}={\frac {P_{\text{cvx}}}{P}}} Some properties of metals and ceramics, such as fracture toughness, have been linked to grain shapes. == An application of shape factors == Greenland, the largest island in the world, has an area of 2,166,086 km2; a coastline (perimeter) of 39,330 km; a north–south length of 2670 km; and an east–west length of 1290 km. The aspect ratio of Greenland is A R = 1290 2670 = 0.483 {\displaystyle A_{R}={\frac {1290}{2670}}=0.483} The circularity of Greenland is f circ = 4 π ( 2166086 ) 39330 2 = 0.0176. {\displaystyle f_{\text{circ}}={\frac {4\pi (2166086)}{39330^{2}}}=0.0176.} The aspect ratio is agreeable with an eyeball-estimate on a globe. Such an estimate on a typical flat map, using the Mercator projection, would be less accurate due to the distorted scale at high latitudes. The circularity is deceptively low, due to the fjords that give Greenland a very jagged coastline (see the coastline paradox). A low value of circularity does not necessarily indicate a lack of symmetry, and shape factors are not limited to microscopic objects.
Sudip Roy (computer scientist)
Sudip Roy is a computer scientist and technology executive. He is the co-founder and chief technology officer of Adaption. He has worked on large-scale machine learning systems at organizations including Google DeepMind and Cohere. == Education == Roy earned a PhD in Computer Science from Cornell University. He holds a B.Tech in Computer Science and Engineering from the Indian Institute of Technology (IIT), Kharagpur. == Career == Sudip worked at Google Brain (now part of Google DeepMind) on systems research and large-scale data management. During his tenure, he contributed to infrastructure projects including Pathways and TensorFlow Extended, which support training and inference workflows for production machine learning models. He later served as Senior Director of Engineering at Cohere, leading work on inference infrastructure and fine-tuning systems. In late 2025, he co-founded the company Adaption Labs with Sara Hooker. The company focuses on developing AI systems designed for continuous learning and adaptation. Roy’s research spans systems for AI and AI for systems, including work on optimizing system performance and compilers. His publications have appeared in conferences such as MLSys, NeurIPS, SIGMOD, and KDD. He has been a program committee member or reviewer for the conferences SIGMOD, VLDB, ICDE, and MLSys. == Awards == He is the recipient of the MLSys Outstanding Paper Award (2022) and the SIGMOD Best Paper Award (2011). He holds multiple patents in machine learning systems, including methods for learned graph optimizations and neural network-based device placement.