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  Unspent transaction output

  In cryptocurrencies, an unspent transaction output (UTXO, often capitalized as UTxO) is a distinctive element in a subset of digital currency models. A UTXO represents a certain amount of cryptocurrency that has been authorized by a sender and is available to be spent by a recipient. The utilization of UTXOs in transaction processes is a key feature of many cryptocurrencies, but it primarily characterizes those implementing the UTXO model. UTXOs employ public key cryptography to ascertain and transfer ownership. More specifically, the recipient's public key is formatted into the UTXO, thereby limiting the capability to spend the UTXO to the account that can demonstrate ownership of the corresponding private key. A valid digital signature associated with the public key must be included for the UTXO to be spent. In the UTXO model, each unit of currency is treated as a discrete object. The history of a UTXO is documented only within the blocks where it is transferred. To ascertain the total balance of an account, one must scan each block to find the latest UTXOs linked to that account. While all nodes within a blockchain network must consent to the block history, the blocks relevant to an account's balance are unique to that account. UTXOs constitute a chain of ownership depicted as a series of digital signatures dating back to the coin's inception, regardless of whether the coin was minted via mining, staking, or another procedure determined by the cryptocurrency protocol. The UTXO model was invented for Bitcoin. Cardano uses an extended version of the UTXO model known as EUTXO. == Origins == The conceptual framework of the UTXO model can be traced back to Hal Finney's Reusable Proofs of Work proposal, which itself was based on Adam Back's 1997 Hashcash proposal. Bitcoin, released in 2009, was the first widespread implementation of the UTXO model in practice. == UTXO model vs. account Model == Cryptocurrencies that utilize the UTXO model function differently compared to those using the account model. In the UTXO model, individual units of cryptocurrency, termed as unspent transaction outputs (UTXOs), are transferred between users, analogous to the exchange of physical cash. This model impacts how transactions and ownership are recorded and verified within the blockchain network. The account model preserves a record of each account and its corresponding balance for every block added to the network. This setup enables quicker balance verification without the need to scan historical blocks, but it increases the raw size of each block (though data compression techniques can be utilized to alleviate this). However, both models necessitate the inspection of past blocks to fully authenticate the origin of coins. In the UTXO model, each object is immutable - units of coins cannot be 'edited' in the same way an account balance is modified when a transaction occurs. Rather, the balance is computed from the transaction history dating back to when the coins were first minted. This simplicity enhances security, as a UTXO either exists in its anticipated form or it does not. In contrast, the account model requires meticulous verification of the account's status during transactions, which can lead to oversights if not conducted correctly. In valid blockchain transactions, only unspent outputs (UTXOs) are permissible for funding subsequent transactions. This requirement is critical to prevent double-spending and fraud. Accordingly, inputs in a transaction are removed from the UTXO set, while outputs create new UTXOs that are added to the set. The holders of private keys, such as those with cryptocurrency wallets, can utilize these UTXOs for future transactions.

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  CogX Festival

  CogX Festival is a global festival focusing on the impact of artificial intelligence (AI) and emerging technology on industry, government, and society. It takes place annually, usually in September, in London, England. Founded by Charlie Muirhead and Tabitha Goldstaub in 2017, CogX aims to facilitate dialogue and understanding about AI and its implications across various sectors. CogX Festival 2023 was held from September 12 to September 14 across multiple sites in London. == History == The inaugural CogX event took place in 2017, intending to bring together experts from diverse fields to discuss the role and impact of AI and emerging technologies. Since then, it has evolved to include a broader range of topics and attract a diverse audience. In 2018, the first CogX Awards festival was hosted. That year, over 50 awards were shown to 300 guests. In 2021, CogX and Hopin, a video conferencing software, signed an agreement lasting 4 years to make CogX a hybrid conference due to the COVID-19 pandemic. CogX 2021 attracted over 5,000 attendees in-person and over 100,000 virtually. In 2022, they returned to a live event format after two years of hybrid events and controlled physical attendance. They also launched the CogX app, which curated insights from the world's top podcasts. In 2023, after he had delivered the keynote address guest speaker Stephen Fry fell off the stage and subsequently broke his leg, hip, pelvis and a "bunch of ribs". A court filing in 2026 revealed that Fry was seeking £100,000 in damages from CogX Festival Ltd and creative agency Blonstein Events. == Programming == The festival features sessions, discussions, workshops, and exhibitions, encompassing various domains of AI and technology. In recent CogX Festivals, they have featured summits encompassing topics like global leadership and industry transformation.

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  Supreme Commander (video game)

  Supreme Commander (sometimes SupCom) is a 2007 real-time strategy video game designed by Chris Taylor and developed by his company, Gas Powered Games. The game is considered to be a spiritual successor, not a direct sequel, to Taylor's 1997 game Total Annihilation. First announced in the August 2005 edition of PC Gamer magazine, the game was released in Europe on February 16, 2007, and in North America on February 20. The standalone expansion Supreme Commander: Forged Alliance was released on November 6 of the same year. The sequel, Supreme Commander 2, was released in 2010. Nowadays, the original Supreme Commander is played through the community client called Forged Alliance Forever; the game has been further developed and balanced, and offers a wide variety of community mods. The gameplay of Supreme Commander focuses on using a giant bipedal mech called an Armored Command Unit (ACU), the so-called "Supreme Commander", to build a base, upgrading units to reach higher technology tiers, and conquering opponents. The player can command one of three factions: the Aeon Illuminate, the Cybran Nation, or the United Earth Federation (UEF). The expansion game added the Seraphim faction. Supreme Commander was highly anticipated in pre-release previews, and was well received by critics, with a Metacritic average of 86 out of 100. == Gameplay == Supreme Commander, like its spiritual predecessors, Total Annihilation and Spring, begins with the player solely possessing a single, irreplaceable construction unit called the "Armored Command Unit," or ACU, the titular Supreme Commander. Normally the loss of this unit results in the loss of the game (Skirmish missions can be set for a variety of victory conditions). These mech suits are designed to be transported through quantum gateways across the galaxy and contain all the materials and blueprints necessary to create an army from a planet's native resources in hours. All standard units except Commanders and summoned Support Commanders (sACU) are self-sufficient robots. All units and structures belong to one of four technology tiers, or "Tech" levels, each tier being stronger and/or more efficient than the previous. Certain lower-tier structures can be upgraded into higher ones without having to rebuild them. The first tier is available at the start of the game and consists of small, relatively weak units and structures. The second tier expands the player's abilities greatly, especially in terms of stationary weapons and shielding, and introduces upgraded versions of tier one units. The third tier level has very powerful assault units designed to overcome the fortifications of the most entrenched player. The fourth tier is a limited range of "experimental" technology. These are usually massive units which take a lot of time and energy to produce, but provide a significant tactical advantage. Supreme Commander features a varied skirmish AI. The typical Easy' and Normal modes are present, but the Hard difficulty level has four possible variants. Horde AI will swarm the player with hordes of lower level units, Tech AI will upgrade its units as fast as possible and assault the player with advanced units, the Balanced AI attempts to find a balance between the two, and the Supreme AI decides which of the three hard strategies is best for the map. The single player campaign consists of eighteen missions, six for each faction. The player is an inexperienced Commander who plays a key role in their faction's campaign to bring the "Infinite War" to an end. Despite the low number of campaign missions, each mission can potentially last hours. At the start of a mission, objectives are assigned for the player to complete. Once the player accomplishes them, the map is expanded, sometimes doubling or tripling in size, and new objectives are assigned. As the mission is commonly divided into three segments, the player will often have to overcome several enemy positions to achieve victory. === Resource management === Because humans have developed replication technology, making advanced use of rapid prototyping and nanotechnology, only two types of resources are required to wage war: Energy and Mass. Energy is obtained by constructing power generators on any solid surface (except fuel generators, which can only be built on fuel deposits), while Mass is obtained either by placing mass extractors on limited mass deposit spots (the most efficient method, although it requires map control) or by building mass fabricators to convert energy into mass. Constructor units can gather energy by "reclaiming" it from organic debris such as trees and mass from rocks and wrecked units. Each player has a certain amount of resource storage, which can be expanded by the construction of storage structures. This gives the player reserves in times of shortage or allows them to stockpile resources. If the resource generation exceeds the player's capacity, the material is wasted. On the contrary, if the storages are depleted and the demand of one of the resources exceeds the production, then all the productions speed is reduced. In addition, if an energy deficit occurs, shields will stop working. An adjacency system allows certain structures to benefit from being built directly adjacent to others. Energy-consuming structures will use less energy when built adjacent to power generators and power generators will produce more energy when built adjacent to power storage structures. The same applies to their mass-producing equivalents. Likewise, factories will consume less energy and mass when built adjacent to power generators and mass fabricators/extractors, respectively. However, by placing structures in close proximity, they become more vulnerable to collateral damage if an adjacent structure is destroyed. Furthermore, most resource generation structures can cause chain reactions when destroyed (especially Tier III structures, which produce large amounts of resources but often have large detonations that can wipe out a nearby army). === Warfare === Supreme Commander uses a "strategic zoom" system that allows the player to seamlessly zoom from a detailed close up view of an individual unit all the way out to a view of the entire map, at which point it resembles a fullscreen version of the minimap denoting individual units with icons. The camera also has a free movement mode and can be slaved to track a selected unit and there is a split screen mode which also supports multiple monitors. This system allows Supreme Commander to use vast maps up to 80 km x 80 km, with players potentially controlling a thousand units each. Units in Supreme Commander are built to scale as they would be in the real world. For example, battleships dwarf submarines. Late into the game, the larger "experimental" units, such as the Cybran Monkeylord, an enormous spider-shaped assault unit, can actually crush smaller enemy units by stepping on them. Because of the wide range of planets colonized by humanity in the setting, the theatres of war range from desert to arctic, and all battlespaces are employed. Technologies emerging in modern warfare are frequently employed in Supreme Commander. For example, stealth technology and both tactical and strategic missile and missile defense systems can be used. Supreme Commander introduced several innovations designed to reduce the amount of micromanagement inherent in many RTS games. Engineers units have the command "assist", that will help follow other engineers and help them finish their orders or improve production rate of factories. In addition, engineers with the order "patrol" will repair units, buildings and recycle wrecks in their along their patrol route. Holding the shift key causes any orders given to a unit (or group of units) to be queued. In this manner a unit may be ordered to attack several targets in succession, or to make best speed to a given point on the map and then attack towards a specified location engaging any hostiles it encounters along the way. After orders have been issued, holding the shift key causes all issued orders to be displayed on the map where they can be subsequently modified to accommodate a change of plan. Further, when a unit is ordered to attack a target, the player can issue an order to perform a coordinated attack to another unit. This order coordinates the arrival time of the units at the target automatically by adjusting the speed of the units involved. As in other RTS games, air transports can be used to convey units to specified destinations, in Supreme Commander though by shift queuing orders a transport containing several units can be ordered to drop specific units at subsequent waypoints. An air transport can also be ordered to create a ferry route, an airbridge wherein any land units ordered to the start of the ferry route will be conveyed by the air transport to the specified destination. The output from a production factory can be routed to a ferry route causing all units co

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  Mata v. Avianca, Inc.

  Mata v. Avianca, Inc. was a U.S. District Court for the Southern District of New York case in which the Court dismissed a personal injury case against the airline Avianca and issued a $5,000 fine to the plaintiffs' lawyers who had submitted fake precedents generated by ChatGPT in their legal briefs. == Background == In February 2022, Roberto Mata filed a personal injury lawsuit in the U.S. District Court for the Southern District of New York against Avianca, alleging that he was injured when a metal serving cart struck his knee during an international flight. The plaintiff's lawyers used ChatGPT to generate a legal motion, which contained numerous fake legal cases involving fictitious airlines with fabricated quotations and internal citations. Avianca's lawyers notified the Court that they had been "unable to locate" a few legal cases cited in the legal motion. The Court could not locate the cases either and ordered the plaintiff's lawyers to provide copies of the cited legal cases. Mata's lawyers provided copies of documents purportedly containing all but one of the legal cases, after ChatGPT assured that the cases "indeed exist" and "can be found in reputable legal databases such as LexisNexis and Westlaw." == Opinion == In May 2023, Judge P. Kevin Castel dismissed the personal injury case against Avianca and ordered the plaintiff's attorneys to pay a $5,000 fine. Judge Castel noted numerous inconsistencies in the opinion summaries, describing one of the legal analyses as "gibberish." Judge Castel held that Mata's lawyers had acted with "subjective bad faith" sufficient for sanctions under Federal Rule of Civil Procedure Rule 11. == Impact == In July 2024, the American Bar Association issued its first formal ethics opinion on the responsibilities of lawyers using generative AI (GAI). The 15-page opinion outlines how the Rules of Professional Conduct apply to the use of GAI in the practice of law. Experts caution that lawyers cannot reasonably rely on the accuracy, completeness, or validity of content generated by GAI tools. Due to the continued usage of GAI in the practice of law, Mata has been described as a landmark case by legal professionals, as it is frequently cited by courts in cases where usage of GAI during the course of proceedings leads to the creation and citation of nonexistent caselaw.

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  Containerization (computing)

  In software engineering, containerization is operating-system-level virtualization or application-level virtualization over multiple resources so that software applications can run in isolated user spaces called containers in any cloud or non-cloud environment, regardless of type or vendor. The term "container" has different meanings in different contexts, and it is important to ensure that the intended definition aligns with the audience's understanding. == Usage == Each container is basically a fully functional and portable cloud or non-cloud computing environment surrounding the application and keeping it independent of other environments running in parallel. Individually, each container simulates a different software application and runs isolated processes by bundling related configuration files, libraries and dependencies. But, collectively, multiple containers share a common operating system kernel (OS). In recent times, containerization technology has been widely adopted by cloud computing platforms like Amazon Web Services, Microsoft Azure, Google Cloud Platform, and IBM Cloud. Containerization has also been pursued by the U.S. Department of Defense as a way of more rapidly developing and fielding software updates, with first application in its F-22 air superiority fighter. == History == The concept of containerization in computing originated from early operating system–level isolation mechanisms. One of the earliest implementations was the chroot system call introduced in Version 7 Unix in 1979, which changed the apparent root directory for a process and its children, providing a basic form of filesystem isolation. In the early 2000s, more advanced forms of operating system–level virtualization were developed. FreeBSD introduced "jails" in 2000, which extended isolation by restricting processes to a subset of system resources. Around the same time, Solaris introduced "zones" (also known as Solaris Containers), providing similar capabilities with resource management and isolation features. Linux later incorporated comparable functionality through kernel features such as namespaces and control groups (cgroups), which enabled isolation of process IDs, network stacks, filesystems, and resource allocation. These features formed the foundation for Linux Containers (LXC), which provided a userspace interface for managing containers. The widespread adoption of containerization accelerated with the release of Docker in 2013, which introduced a standardized format for packaging applications and their dependencies, along with tooling for image distribution and container management. == Types of containers == OS containers Application containers == Security issues == Because of the shared OS, security threats can affect the whole containerized system. In containerized environments, security scanners generally protect the OS, but not the application containers, which adds unwanted vulnerability. == Container management, orchestration, clustering == Container orchestration or container management is mostly used in the context of application containers. Implementations providing such orchestration include Kubernetes and Docker swarm. == Container cluster management == Container clusters need to be managed. This includes functionality to create a cluster, to upgrade the software or repair it, balance the load between existing instances, scale by starting or stopping instances to adapt to the number of users, to log activities and monitor produced logs or the application itself by querying sensors. Open-source implementations of such software include OKD and Rancher. Quite a number of companies provide container cluster management as a managed service, like Alibaba, Amazon, Google, and Microsoft.

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  Plants vs. Zombies: Replanted

  Plants vs. Zombies: Replanted is a 2025 tower defense video game developed by PopCap Seattle, The Lost Pixels, and published by Electronic Arts. It is a remaster of the 2009 game Plants vs. Zombies, introducing upscaled graphics and new additional content. Plants vs. Zombies: Replanted was released for video game consoles and personal computers on October 23, 2025. It received generally positive reviews from critics, but was criticized by the original game's development team for including fabricated concept art and for mishandling the soundtrack. == Gameplay == Plants vs. Zombies: Replanted follows the same gameplay of the original Plants vs. Zombies game with very minor changes. It is a lane-based tower defense game where the player has to defend their home from incoming zombies. The player can place various plants by spending "sun", the game's currency during levels. Sun icons can be collected from the sky during daytime and from sun-producing plants such as sunflowers. Some plants can attack zombies while some can act as defense. If all zombies are defeated in a level, the player wins. If a zombie reaches the left side of the line, a lawn mower—or other similar, relevant object—will activate and clear the row of any zombies, but if the lawn mower has already been used, and another zombie crosses, the game is over. === Replanted features === Plants vs. Zombies: Replanted contains up to 4K upscaled graphics and widescreen support, in comparison to the original game's static 800x600 resolution and 4:3 aspect ratio. Replanted now has full controller support and features local multiplayer modes ported from the original game's seventh generation console ports: co-op, where two players play together with assigned roles; and Versus, where one plays as the plants and the other as the zombies. No online multiplayer is planned, however support for Steam Remote Play was later added in a patch as an alternative for Windows users. Replanted also contains quality-of-life features. Gameplay can now be sped up by the player's will, with a max speed increase of 2.5x. Sun icons can now be mass collected using the "Sun Magnet." On Windows, players can quick-select plants from their seed bank using the number keys as hotkeys. Replanted also introduces two new additional game modes. "Cloudy Day" is a set of non-linear levels in the Adventure campaign. These levels only allow Sunflowers as sun-producing plants. During these levels, the amount of sun dropped from the sky and produced by plants are lowered. At certain times, rain clouds will move over the lawn. While these clouds are present, sun will stop appearing from the sky and from Sunflowers. However, all plants will cost around half their original price and have significantly faster recharge times. "R.I.P. Mode" is a harder difficulty of the Adventure campaign, but the player is forced back to the beginning if they lose a single level. Replanted additionally features "bonus levels" included as non-linear levels in the Adventure campaign. These include 10 new minigames that were previously unused in the original game. In a later update, Replanted added "Survival: Endless" levels to all five areas of the game instead of just the daytime pool. == Development == The existence of a Plants vs. Zombies remaster was revealed in an interview with Janet Robin from The String Revolution, who they did a vinyl collaboration with the franchise in 2025 with Iam8bit. Janet stated that EA commissioned them to record an acoustic composition of the track "Crazy Dave" to be used for an "anniversary edition" of the game. The song would be additionally be a tribute to the song "Bad Guy", which artist Billie Eilish has stated to be somewhat similar to the track. Plants vs. Zombies Replanted was officially announced in a Nintendo Direct presentation in late July 2025. As an incentive, people who pre-ordered the game are given an in-game retro-styled skin of the Peashooter. Replanted was showcased at PAX West on August 25, 2025. A dev diary for Plants vs. Zombies: Replanted was uploaded to YouTube on October 17, 2025. The video features Nick Reinhart, Jake Neri, and Matt Townsend. A developer panel for the game was available during TwitchCon 2025. == Release == Plants vs. Zombies: Replanted was released for Nintendo Switch, Nintendo Switch 2, PlayStation 4, PlayStation 5, Xbox One, Xbox Series X and Series S, and personal computers on October 23, 2025. It was leaked onto the internet on October 17, 2025. Players discovered multiple software bugs, and multiple assets alleged to be upscaled by generative artificial intelligence were found, leading to backlash. Numerous bugs were fixed in a day-one patch on October 23, 2025. == Reception == === Critical response === The versions of Plants vs. Zombies: Replanted for Windows, PlayStation 5, and Nintendo Switch 2 received "generally favorable" reviews from critics, according to review aggregator website Metacritic, while the Xbox Series X version received "mixed or average" reviews. According to OpenCritic, 57% of critics recommended it. IGN's Alessandro Fillari called it "a good way to get re-acquainted with one of the quirkiest puzzle-strategy games of the 2000s", while acknowledging its questionable decisions. Shacknews' David Craddock said it was his favorite version of Plants vs. Zombies, stating, "it packs everything fans loved about the original game, plus lots more" while justifying its US$20 price. The Verge described Replanted as "a time capsule from a simpler, happier time". Kyle Hilliard from Game Informer praised its faithfulness, complimenting the new animations and character designs that did not alter its memorability. Noah Hunter for Final Weapon described the remake as solid, though criticized the lack of certain features and containing bugs that gate it from being excellent. Ben Lyons from Gamereactor stated Replanted is the same as the original overall, despite believing the £18 price is not justified. === Original developers === Rich Werner, the original game's character designer, claims that some concept art contained in the game, speculated to be for Plants vs. Zombies: Garden Warfare (2014), did not originate from the original's development. Werner also stated that concept art for the Disco Zombie is fabricated; the design for the Disco Zombie was created after the estate of Michael Jackson requested the original Dancing Zombie, who resembles Michael Jackson from his Thriller music video, be removed from the game. On October 19, 2026, composer Laura Shigihara expressed her dissatisfaction with the lack of dynamic music in the game. Dynamic music would later be implemented in a later patch. In an interview featuring Rich Werner and user interface designer Matt Holmberg on April 29, 2026, Werner revealed that he and Shigihara were contacted by EA to make a music video to market Replanted. However, after the game was leaked, Werner's response on social media led EA to cancel the collaboration.

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  Fuzzy cognitive map

  A fuzzy cognitive map (FCM) is a cognitive map within which the relations between the elements (e.g. concepts, events, project resources) of a "mental landscape" can be used to compute the "strength of impact" of these elements. Fuzzy cognitive maps were introduced by Bart Kosko. Robert Axelrod introduced cognitive maps as a formal way of representing social scientific knowledge and modeling decision making in social and political systems, then brought in the computation. == Details == Fuzzy cognitive maps are signed fuzzy directed graphs. Spreadsheets or tables are used to map FCMs into matrices for further computation. FCM is a technique used for causal knowledge acquisition and representation, it supports causal knowledge reasoning process and belong to the neuro-fuzzy system that aim at solving decision making problems, modeling and simulate complex systems. Learning algorithms have been proposed for training and updating FCMs weights mostly based on ideas coming from the field of Artificial Neural Networks. Adaptation and learning methodologies used to adapt the FCM model and adjust its weights. Kosko and Dickerson (Dickerson & Kosko, 1994) suggested the Differential Hebbian Learning (DHL) to train FCM. There have been proposed algorithms based on the initial Hebbian algorithm; others algorithms come from the field of genetic algorithms, swarm intelligence and evolutionary computation. Learning algorithms are used to overcome the shortcomings that the traditional FCM present i.e. decreasing the human intervention by suggested automated FCM candidates; or by activating only the most relevant concepts every execution time; or by making models more transparent and dynamic. Fuzzy cognitive maps (FCMs) have gained considerable research interest due to their ability in representing structured knowledge and model complex systems in various fields. This growing interest led to the need for enhancement and making more reliable models that can better represent real situations. A first simple application of FCMs is described in a book of William R. Taylor, where the war in Afghanistan and Iraq is analyzed. In Bart Kosko's book Fuzzy Thinking, several Hasse diagrams illustrate the use of FCMs. As an example, one FCM quoted from Rod Taber describes 11 factors of the American cocaine market and the relations between these factors. For computations, Taylor uses pentavalent logic (scalar values out of {-1,-0.5,0,+0.5,+1}). That particular map of Taber uses trivalent logic (scalar values out of {-1,0,+1}). Taber et al. also illustrate the dynamics of map fusion and give a theorem on the convergence of combination in a related article. While applications in social sciences introduced FCMs to the public, they are used in a much wider range of applications, which all have to deal with creating and using models of uncertainty and complex processes and systems. Examples: In business FCMs can be used for product planning and decision support. In economics, FCMs support the use of game theory in more complex settings. In education for modeling Critical Success Factors of Learning Management Systems. In medical applications to model systems, provide diagnosis, develop decision support systems and medical assessment. In engineering for modeling and control mainly of complex systems and reliability engineering In project planning FCMs help to analyze the mutual dependencies between project resources. In robotics FCMs support machines to develop fuzzy models of their environments and to use these models to make crisp decisions. In computer assisted learning FCMs enable computers to check whether students understand their lessons. In expert systems a few or many FCMs can be aggregated into one FCM in order to process estimates of knowledgeable persons. In IT project management, a FCM-based methodology helps to success modelling, risk analysis and assessment, IT scenarios FCMappers is an international online community for the analysis and the visualization of fuzzy cognitive maps. FCMappers offer support for starting with FCM and also provide a Microsoft Excel-based tool that is able to check and analyse FCMs. The output is saved as Pajek file and can be visualized within third party software like Pajek, Visone, etc. They also offer to adapt the software to specific research needs. Additional FCM software tools, such as Mental Modeler, have recently been developed as a decision-support tool for use in social science research, collaborative decision-making, and natural resource planning.

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  Dartmouth workshop

  The Dartmouth Summer Research Project on Artificial Intelligence was a 1956 summer workshop widely considered to be the founding event of artificial intelligence as a field. The workshop has been referred to as "the Constitutional Convention of AI". The project's four organizers, Claude Shannon, John McCarthy, Nathaniel Rochester and Marvin Minsky, are considered some of the "founding fathers" of AI. However it was not the first conference devoted to what would now be described as the question of artificial intelligence: it postdated meetings such as the 1951 Paris cybernetics conference and the Macy meetings. The project lasted approximately six to eight weeks and consisted largely of brainstorming sessions. Eleven mathematicians and scientists originally planned to attend; not all of them attended, but more than ten others came for short times. == Background == In the early 1950s, there were various names for the field of "thinking machines": cybernetics, automata theory, and complex information processing. The variety of names suggests the variety of conceptual orientations. In 1955, John McCarthy, then a young Assistant Professor of Mathematics at Dartmouth College, decided to organize a group to clarify and develop ideas about thinking machines. He picked the name 'Artificial Intelligence' for the new field. He chose the name partly for its neutrality; avoiding a focus on narrow automata theory, and avoiding cybernetics which was heavily focused on analog feedback, as well as him potentially having to accept the assertive Norbert Wiener as guru or having to argue with him. In early 1955, McCarthy approached the Rockefeller Foundation to request funding for a summer seminar at Dartmouth for about 10 participants. In June, he and Claude Shannon, a founder of information theory then at Bell Labs, met with Robert Morison, Director of Biological and Medical Research to discuss the idea and possible funding, though Morison was unsure whether money would be made available for such a visionary project. On September 2, 1955, the project was formally proposed by McCarthy, Marvin Minsky, Nathaniel Rochester and Claude Shannon. The proposal is credited with introducing the term 'artificial intelligence'. The Proposal states: We propose that a 2-month, 10-man study of artificial intelligence be carried out during the summer of 1956 at Dartmouth College in Hanover, New Hampshire. The study is to proceed on the basis of the conjecture that every aspect of learning or any other feature of intelligence can in principle be so precisely described that a machine can be made to simulate it. An attempt will be made to find how to make machines use language, form abstractions and concepts, solve kinds of problems now reserved for humans, and improve themselves. We think that a significant advance can be made in one or more of these problems if a carefully selected group of scientists work on it together for a summer. The proposal goes on to discuss computers, natural language processing, neural networks, theory of computation, abstraction and creativity (these areas within the field of artificial intelligence are considered still relevant to the work of the field). On May 26, 1956, McCarthy notified Robert Morison of the planned 11 attendees: For the full period: 1) Dr. Marvin Minsky 2) Dr. Julian Bigelow 3) Professor D.M. Mackay 4) Mr. Ray Solomonoff 5) Mr. John Holland 6) Dr. John McCarthy For four weeks: 7) Dr. Claude Shannon 8) Mr. Nathaniel Rochester 9) Mr. Oliver Selfridge For the first two weeks: 10) Dr. Allen Newell 11) Professor Herbert Simon He noted, "we will concentrate on a problem of devising a way of programming a calculator to form concepts and to form generalizations. This of course is subject to change when the group gets together." The actual participants came at different times, mostly for much shorter times. Trenchard More replaced Rochester for three weeks and MacKay and Holland did not attend—but the project was set to begin. Around June 18, 1956, the earliest participants (perhaps only Ray Solomonoff, maybe with Tom Etter) arrived at the Dartmouth campus in Hanover, N.H., to join John McCarthy who already had an apartment there. Solomonoff and Minsky stayed at Professors' apartments, but most would stay at the Hanover Inn. == Dates == The Dartmouth Workshop is usually said to have run for six weeks. Ray Solomonoff's notes taken during the workshop, however, indicate that it ran for roughly eight weeks, from about June 18 to August 17. Solomonoff's notes start on June 22; June 28 mentions Minsky, June 30 mentions Hanover, N.H., July 1 mentions Tom Etter. On August 17, Solomonoff gave a final talk. == Participants == Initially, McCarthy lost his list of attendees. Instead, after the workshop, McCarthy sent Solomonoff a preliminary list of participants and visitors plus those interested in the subject. 47 people were listed. Solomonoff, however, made a list of participants in his notes of the summer project: Ray Solomonoff Marvin Minsky John McCarthy Claude Shannon Trenchard More Nat Rochester Oliver Selfridge Julian Bigelow W. Ross Ashby W.S. McCulloch Abraham Robinson Tom Etter John Nash David Sayre Arthur Samuel Kenneth R. Shoulders Shoulders' friend Alex Bernstein Herbert Simon Allen Newell Shannon attended Solomonoff's talk on July 10 and Bigelow gave a talk on August 15. Solomonoff doesn't mention Bernard Widrow, but in 1994 Widrow said that he and an unidentified colleague from the same lab in MIT had attended for one week. In the same interview Widrow recalled that "I think [Wesley] Clark and [Belmont] Farley were there from Lincoln Lab." Trenchard mentions R. Culver and Solomonoff mentions Bill Shutz. Herb Gelernter didn't attend, but was influenced later by what Rochester learned. In an article in IEEE Spectrum, Grace Solomonoff additionally identifies Peter Milner in a photo taken by Nathaniel Rochester in front of Dartmouth Hall. Ray Solomonoff, Marvin Minsky, and John McCarthy were the only three who stayed for the full time. Trenchard took attendance during two weeks of his three-week visit. From three to about eight people would attend the daily sessions. == Event and aftermath == They had the entire top floor of the Dartmouth Math Department to themselves, and most weekdays they would meet at the main math classroom where someone might lead a discussion focusing on his ideas, or more frequently, a general discussion would be held. It was not a directed group research project; discussions covered many topics, but several directions are considered to have been initiated or encouraged by the Workshop: the rise of symbolic methods, systems focused on limited domains (early expert systems), and deductive systems versus inductive systems. One participant, Arthur Samuel, said, "It was very interesting, very stimulating, very exciting". Ray Solomonoff kept notes giving his impression of the talks and the ideas from various discussions. === McCarthy's 1956 AI distribution list === This is the list in the "People Interested in the Artificial Intelligence Problem" document which McCarthy produced in 1956, partly in lieu of a list of attendees at the Dartmouth workshop. According to McCarthy the list was "being sent to the people on the list and a few others", and its purpose was "to let those on it know who is interested in receiving documents on the problem" of artificial intelligence. McCarthy also promised to deliver them a report on the Dartmouth conference, and to send an updated list soon afterwards. It includes people who did not attend the conference and does not include everyone who did attend it.

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  Adobe Presenter

  Adobe Presenter is eLearning software released by Adobe Systems available on the Microsoft Windows platform as a Microsoft PowerPoint plug-in, and on both Windows and OS X as the screencasting and video editing tool Adobe Presenter Video Express. It is mainly targeted towards learning professionals and trainers. In addition to recording one's computer desktop and speech, it also provides the option to add quizzes and track performance by integrating with learning management systems. Adobe Presenter was designed to replace the discontinued Adobe Ovation software, which had similar functions. == Predecessor == Adobe Ovation was originally released by Serious Magic. It converted PowerPoint slides into visual presentations with additional effects. Ovation included themes called PowerLooks that could add motion and polish the presentations. They were available in a variety of color variations complete with animated backgrounds and dynamic text effects. Ovation could make text with jagged edges more readable. TimeKeeper could be used to set the period of the presentation, and the PointPrompter scrolled down the notes. Ovation's development has been discontinued, nor does it support PowerPoint 2007. == Features == The main purpose of Adobe Presenter is to capture on-screen presentations and convert them into more interactive and engaging videos. Support is given to convert Microsoft PowerPoint 2010 and 2013 presentations into videos. It also allows for content authoring on PowerPoint and ActionScript 3, and offers integration with Adobe Captivate. Slide branching enables users to control slide navigation and titles and create complex slide branching to guide viewers through the content of the presentation. Video editing tools are also provided, and offer the ability to upload to video-sharing platforms such as YouTube, Vimeo and other sites. Multimedia features such as annotations, eLearning templates, actors, audio narration and drag-and-drop elements enrich users' presentations. Quizzes and surveys is another highlighted feature, which include generating question pools, importing questions from existing quizzes and in-course collaboration which allows presenters to receive feedback by allowing them to comment on specific content within a course or ask questions for more clarity. Presenters could opt to receive feedback from viewers through video analytics and create Experience API, SCORM and AICC-compliant content. Options to publish to Adobe Connect are provided. Other unique features include universal standards support, file size control, navigational restrictions among others.

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  Speech synthesis

  Speech synthesis is the artificial production of human speech. A computer system used for this purpose is called a speech synthesizer, and can be implemented in software or hardware products. A text-to-speech (TTS) system converts normal language text into speech; other systems render symbolic linguistic representations like phonetic transcriptions into speech. The reverse process is speech recognition. Synthesized speech can be created by concatenating pieces of recorded speech that are stored in a database. Systems differ in the size of the stored speech units; a system that stores phones or diphones provides the largest output range, but may lack clarity. For specific usage domains, the storage of entire words or sentences allows for high-quality output. Alternatively, a synthesizer can incorporate a model of the vocal tract and other human voice characteristics to create a completely "synthetic" voice output. The quality of a speech synthesizer is judged by its similarity to the human voice and by its ability to be understood clearly. An intelligible text-to-speech program allows people with visual impairments or reading disabilities to listen to written words on a home computer. The earliest computer operating system to have included a speech synthesizer was Unix in 1974, through the Unix speak utility. In 2000, Microsoft Sam was the default text-to-speech voice synthesizer used by the narrator accessibility feature, which shipped with all Windows 2000 operating systems, and subsequent Windows XP systems. A text-to-speech system (or "engine") is composed of two parts: a front-end and a back-end. The front-end has two major tasks. First, it converts raw text containing symbols like numbers and abbreviations into the equivalent of written-out words. This process is often called text normalization, pre-processing, or tokenization. The front-end then assigns phonetic transcriptions to each word, and divides and marks the text into prosodic units, like phrases, clauses, and sentences. The process of assigning phonetic transcriptions to words is called text-to-phoneme or grapheme-to-phoneme conversion. Phonetic transcriptions and prosody information together make up the symbolic linguistic representation that is output by the front-end. The back-end—often referred to as the synthesizer—then converts the symbolic linguistic representation into sound. In certain systems, this part includes the computation of the target prosody (pitch contour, phoneme durations), which is then imposed on the output speech. == History == Long before the invention of electronic signal processing, some people tried to build machines to emulate human speech. There were also legends of the existence of "Brazen Heads", such as those involving Pope Silvester II (d. 1003 AD), Albertus Magnus (1198–1280), and Roger Bacon (1214–1294). In 1779, the German-Danish scientist Christian Gottlieb Kratzenstein won the first prize in a competition announced by the Russian Imperial Academy of Sciences and Arts for models he built of the human vocal tract that could produce the five long vowel sounds (in International Phonetic Alphabet notation: [aː], [eː], [iː], [oː] and [uː]). There followed the bellows-operated "acoustic-mechanical speech machine" of Wolfgang von Kempelen of Pressburg, Hungary, described in a 1791 paper. This machine added models of the tongue and lips, enabling it to produce consonants as well as vowels. In 1837, Charles Wheatstone produced a "speaking machine" based on von Kempelen's design, and in 1846, Joseph Faber exhibited the "Euphonia". In 1923, Paget resurrected Wheatstone's design. In the 1930s, Bell Labs developed the vocoder, which automatically analyzed speech into its fundamental tones and resonances. From his work on the vocoder, Homer Dudley developed a keyboard-operated voice-synthesizer called The Voder (Voice Demonstrator), which he exhibited at the 1939 New York World's Fair. Franklin S. Cooper and his colleagues at Haskins Laboratories built the pattern playback in the late 1940s and completed it in 1950. There were several different versions of this hardware device; only one currently survives. The machine converts pictures of the acoustic patterns of speech in the form of a spectrogram back into sound. Using this device, Alvin Liberman and colleagues discovered acoustic cues for the perception of phonetic segments (consonants and vowels). === Electronic devices === The first computer-based speech-synthesis systems originated in the late 1950s. Noriko Umeda et al. developed the first general English text-to-speech system in 1968, at the Electrotechnical Laboratory in Japan. In 1961, physicist John Larry Kelly, Jr and his colleague Louis Gerstman used an IBM 704 computer to synthesize speech, an event among the most prominent in the history of Bell Labs. Kelly's voice recorder synthesizer (vocoder) recreated the song "Daisy Bell", with musical accompaniment from Max Mathews. Coincidentally, Arthur C. Clarke was visiting his friend and colleague John Pierce at the Bell Labs Murray Hill facility. Clarke was so impressed by the demonstration that he used it in the climactic scene of his screenplay for his novel 2001: A Space Odyssey, where the HAL 9000 computer sings the same song as astronaut Dave Bowman puts it to sleep. Despite the success of purely electronic speech synthesis, research into mechanical speech-synthesizers continues. Linear predictive coding (LPC), a form of speech coding, began development with the work of Fumitada Itakura of Nagoya University and Shuzo Saito of Nippon Telegraph and Telephone (NTT) in 1966. Further developments in LPC technology were made by Bishnu S. Atal and Manfred R. Schroeder at Bell Labs during the 1970s. LPC was later the basis for early speech synthesizer chips, such as the Texas Instruments LPC Speech Chips used in the Speak & Spell toys from 1978. In 1975, Fumitada Itakura developed the line spectral pairs (LSP) method for high-compression speech coding, while at NTT. From 1975 to 1981, Itakura studied problems in speech analysis and synthesis based on the LSP method. In 1980, his team developed an LSP-based speech synthesizer chip. LSP is an important technology for speech synthesis and coding, and in the 1990s was adopted by almost all international speech coding standards as an essential component, contributing to the enhancement of digital speech communication over mobile channels and the internet. In 1975, MUSA was released, and was one of the first Speech Synthesis systems. It consisted of a stand-alone computer hardware and a specialized software that enabled it to read Italian. A second version, released in 1978, was also able to sing Italian in an "a cappella" style. Dominant systems in the 1980s and 1990s were the DECtalk system, based largely on the work of Dennis Klatt at MIT, and the Bell Labs system; the latter was one of the first multilingual language-independent systems, making extensive use of natural language processing methods. Handheld electronics featuring speech synthesis began emerging in the 1970s. One of the first was the Telesensory Systems Inc. (TSI) Speech+ portable calculator for the blind in 1976. Other devices had primarily educational purposes, such as the Speak & Spell toy produced by Texas Instruments in 1978. Fidelity released a speaking version of its electronic chess computer in 1979. The first video game to feature speech synthesis was the 1980 shoot 'em up arcade game, Stratovox (known in Japan as Speak & Rescue), from Sun Electronics. The first personal computer game with speech synthesis was Manbiki Shoujo (Shoplifting Girl), released in 1980 for the PET 2001, for which the game's developer, Hiroshi Suzuki, developed a "zero cross" programming technique to produce a synthesized speech waveform. Another early example, the arcade version of Berzerk, also dates from 1980. The Milton Bradley Company produced the first multi-player electronic game using voice synthesis, Milton, in the same year. In 1976, Computalker Consultants released their CT-1 Speech Synthesizer. Designed by D. Lloyd Rice and Jim Cooper, it was an analog synthesizer built to work with microcomputers using the S-100 bus standard. Synthesized voices typically sounded male until 1990, when Ann Syrdal, at AT&T Bell Laboratories, created a female voice. Ray Kurzweil predicted in 2005 that as the cost-performance ratio caused speech synthesizers to become cheaper and more accessible, more people would benefit from the use of text-to-speech programs. === Artificial intelligence === In September 2016, DeepMind released WaveNet, which demonstrated that deep learning models are capable of modeling raw waveforms and generating speech from acoustic features like spectrograms or mel-spectrograms, starting the field of deep learning speech synthesis. Although WaveNet was initially considered to be computationally expensive and slow to be used in consumer products at the time, a year after its

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  Amazon Bedrock

  Amazon Bedrock is a cloud computing service provided by Amazon Web Services (AWS) for building generative artificial intelligence applications. Launched in 2023, the platform provides a unified API to access foundation models (FMs) from several AI companies, alongside related tools. Bedrock is a serverless computing service which competes with similar enterprise AI platforms such as Microsoft Foundry and Google Cloud Platform. == History == Amazon announced Bedrock on April 13, 2023. The service became generally available on September 28, 2023. Throughout 2024 and 2025, AWS expanded the service to include AI agents, which allow models to interact with external systems. == Features == Knowledge Bases: a managed workflow for Retrieval-Augmented Generation (RAG), which allows models to pull facts from private data stored in Amazon S3. Guardrails: a security feature that allows administrators to set content filters and personally identifiable information redaction across all models in the platform to increase the safety and compliance of AI deployments. == PartyRock == In November 2023, Amazon launched PartyRock, a web-based no-code environment for building generative AI applications. The platform uses a natural language interface to translate user descriptions into software widgets. These widgets enable specific AI behaviors, including text-based prompts, conversational agents, generating images, and the summarization and querying of user-uploaded documents. Although it initially launched with a limited-time free trial, AWS transitioned the service to a recurring free daily usage credit model in early 2025.

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  Painworth

  PainWorth is a justice, legal and insurance services application founded by Canadian entrepreneurs Mike Zouhri, Chris Trudel and Ryan Bencic. The application is a "robot lawyer" that uses artificial intelligence to automate personal injury claims for injury victims. It is currently available in Canada and the United States. PainWorth has been featured by several news outlets, including CTV, Global News, CBC, and has also been featured by the American Bar Association and LexisNexis for its role addressing social issues such as access to justice and other systemic issues in the legal and insurance industry. == Application == PainWorth began as a tool for calculating non-pecuniary damages for injury victims but has since expanded beyond a personal injury calculator to include features that help injury victims and business users with pecuniary damages, economic calculations, prescribed rates and providing informational guides to help navigate settlement negotiation, managing claims records and other issues encountered by self-represented litigants or claims managers. The platform makes use of automation to provide free user-guided calculations, steps and processes to successfully settle an injury claim. The application is supported by Microsoft Azure. == Personal Injury Calculator == PainWorth is the first service to use Artificial Intelligence to interpret case law in order to determine the value of pain and suffering incurred by specific injury types and injury severities. The cited case law is used as evidence and presented in statistical models to determine an accurate valuation compliant with the jurisdiction, regulatory rules and case complexities. == General Damages Calculator == PainWorth also offers a personal injury settlement calculator that assesses general damages based on specific case complexities and jurisdiction. The service takes into account medical complications and recovery in order to calculate the fair valuation. == Injury Settlement Platform == PainWorth insurance settlement platform facilitates a direct and automated way resolution center to settle cases for their assessed value without enduring the hardship of litigation. In 2021, Painworth won the title of World's Best Emerging Insurance Product for the development of this platform. == History == In 2019, Mike Zouhri was struck by a drunk driver which left him seriously injured and resulted in a lawsuit. Frustrated by the slow and expensive process, Zouhri went down to the law library and learned how to manage injury claims. After learning the process, he partnered lawyers and legal advisors to create an app to allow users to quickly settle their own injury claims fairly and accurately. Immediately after its launch, PainWorth quickly became widely used by thousands of users and gained significant media coverage. Global News reported that the bot had successfully helped people with more than $10 million in claims in only a few short months, all free of charge. In July 2020, PainWorth began raising concern over injustices and gender bias in the legal system. in Canadian courts.

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  Meta AI

  Meta AI is a research division of Meta (formerly Facebook) that develops artificial intelligence and augmented reality technologies. == History == Meta AI was founded in 2013 as Facebook Artificial Intelligence Research (FAIR). It has workspaces in Menlo Park, London, New York City, Paris, Seattle, Pittsburgh, Tel Aviv, and Montreal as of 2025. In 2016, FAIR partnered with Google, Amazon, IBM, and Microsoft in creating the Partnership on Artificial Intelligence to Benefit People and Society. Meta AI was directed by Yann LeCun until 2018, when Jérôme Pesenti succeeded the role. Pesenti is formerly the CTO of IBM's big data group. FAIR's research includes self-supervised learning, generative adversarial networks, document classification and translation, and computer vision. FAIR released Torch deep-learning modules as well as PyTorch in 2017, an open-source machine learning framework, which was subsequently used in several deep learning technologies, such as Tesla's autopilot and Uber's Pyro. That same year, a pair of chatbots were falsely rumored to be discontinued for developing a language that was unintelligible to humans. FAIR clarified that the research had been shut down because they had accomplished their initial goal to understand how languages are generated by their models, rather than out of fear. FAIR was renamed Meta AI following the rebranding that changed Facebook, Inc. to Meta Platforms Inc. On October 1, 2025, Facebook announced "We will soon use your interactions with AI at Meta to personalize the content and ads you see". == Virtual assistant == Meta AI is also the name of the virtual assistant developed by the team, now integrated as a chatbot into Meta's social networking products. It is also available as a subscription-based stand-alone app. The virtual assistant was pre-installed on the second generation of Ray-Ban Meta smartglasses, and can incorporate inputs from the glasses' cameras after an update. It is also available on Quest 2 and newer HMDs. Since May 2024, the chatbot has summarized news from various outlets without linking directly to original articles, including in Canada, where news links are banned on its platforms. This use of news content without compensation and attribution has raised ethical and legal concerns, especially as Meta continues to reduce news visibility on its platforms. == Current research == === Natural language processing and chatbot === Natural language processing is the ability for machines to understand and generate natural language. The team is also researching unsupervised machine translation and multilingual chatbots. ==== Galactica ==== Galactica is a large language model (LLM) designed for generating scientific text. It was available for three days from 15 November 2022, before being withdrawn for generating racist and inaccurate content. ==== Llama ==== Llama is an LLM released in February 2023. As of January 2026, the most recent release is the Llama 4. === Hardware === Meta used CPUs and in-house custom chips before 2022; they switched to Nvidia GPUs since then. MTIA v1, one of their early chips, is designed for the company's content recommendation algorithms. It was fabricated on TSMC's 7 nm process technology and consumed 25W, capable of 51.2 TFlops FP16. == Controversy == The French media outlet Mediapart reports that in 2022, Facebook's parent company illegally used works accumulated by the pirate site LibGen to train its artificial intelligence.

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  Artificial intelligence in pharmacy

  Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.

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  Tilly Norwood

  Tilly Norwood is a character created using generative artificial intelligence in 2025 by Xicoia, the AI division of Particle6 Group, a production company founded by Eline Van der Velden. "AI Commissioner", the first project to feature the Norwood character, was criticised by reviewers for The Guardian, PC Gamer, and The A.V. Club. A press release that talent agencies expressed interest in representing the character attracted strong criticism from Hollywood actors and firms, prompting allegations of personality rights violations and arguments over the impact of the character on production costs in the media industry. == History == Norwood was created by Xicoia, which was founded in February 2025 as the artificial intelligence (AI) division of Particle6, a production company founded by Dutch actress and producer Eline Van der Velden in 2015. Van der Velden had previously starred in a satirical comedy series for BBC Three based around her character Miss Holland, whom she created in 2012 as a parody of beauty standards. She stated that the process of creating Norwood took "a long time" and compared the process to that of writers creating characters. An Instagram account under Norwood's name, with posts dating back to 6 May 2025, had gained 50,000 followers by October 3, and featured AI-generated modelling shots, selfies, and epic film scenes. Van der Velden stated in July 2025 that she intended Norwood to be the next Scarlett Johansson or Natalie Portman and later said that audiences were more interested in a film's story than whether its actors were real. Particle6 has claimed that using Norwood could cut production costs by 90%. On 30 July 2025, a comedy sketch named "AI Commissioner" was released, featuring Norwood as an "actress" along with other AI-generated characters. It was created with ten AI software tools, with a script generated by ChatGPT. Stuart Heritage of The Guardian described it as technically competent but "relentlessly unfunny to watch", with "sloppily written, woodenly delivered dialogue", and that Norwood's teeth kept "blurring into a single white block." Joshua Wolens of PC Gamer wrote that Norwood's exaggerated mouth movements gave the impression "that her skeleton was about to leave her body", while William Hughes of The A.V. Club wrote that the sketch's attempt at mimicking human body and mouth movements produced "such a hideous uncanny valley effect" that it gave them "a full-on case of the screaming fantods". By October 2, the sketch had been viewed more than 700,000 times on YouTube. Xicoia was officially announced on 27 September 2025, at the Zurich Summit, part of the Zurich Film Festival; there, van der Velden unveiled Norwood and later joined a panel with Verena Puhm, head of Luma AI's Studio Dream Lab LA. They suggested that media companies were quietly embracing AI and that public announcements of AI-generated works were imminent. Van der Velden claimed that studios had dropped their objections by May after being opposed in February, and that multiple talent agencies were considering representing Norwood. The latter claim drew heightened attention to the character and was printed as fact by Deadline under the headline "Talent Agents Circle AI Actress Tilly Norwood." The report caused controversy, with Vulture describing the reaction to it as "Hollywood [lurching] into a fresh wave of existential panic" while being critical of Deadline's reporting, writing that "when Deadline called it a 'revelation' and published the supposed interest as fact without verification, [it] metastasized into a full-fledged cyberpunk news cycle", and that "by Tuesday, it had grown like wildfire." By September 2025, AI-generated videos had been released depicting Norwood on a red carpet, crying on the sofa of The Graham Norton Show, and starring in mock trailers for sci-fi, fantasy, horror, and action films. Later that month, actresses Melissa Barrera, Kiersey Clemons, and Natasha Lyonne suggested boycotting any agency who signed Norwood, while Mara Wilson asked why none of the "hundreds of living young women whose faces were composited together" to create Norwood could be hired instead. Also around this time, Emily Blunt described Norwood as "really, really scary", and Sophie Turner, Toni Collette, Ralph Ineson, and Ariel Winter also expressed disapproval, while Lukas Gage, Odessa A'zion, and Trace Lysette joked about having supposedly worked with Norwood and finding her incompetent and unpleasant to work with, with Gage claiming that "She was a nightmare to work with!" and "She couldn't hit her mark and she was late!" and Lysette adding "She cut me in line at lunch one day and didn't even say excuse me. She won't get far." Jenelle Riley, Nicholas Alexander Chavez, and the American union SAG-AFTRA stated that they do not consider Norwood an actress. The Gersh Agency and WME both announced that they would not sign Norwood. Whoopi Goldberg and Charlie Fink expressed scepticism that AI could replace jobs. Esquire UK reported that a post on Deadline's Instagram account about Norwood also sparked "varying levels of disgust and outrage" in its comments section from Adelaide Kane, Eiza González, Katie Cassidy, Jewel Staite, Lucy Hale, Stephen Sean Ford, and others, singling out González's comment, saying "Shame on whoever is trying to normalize this. Horrific and terrifying." Actor Bronson Pinchot expressed concern that Norwood could take his job. The British union Equity and the Canadian union ACTRA also condemned Norwood. Following this criticism, Van der Velden released a statement claiming Norwood was "not a replacement for a human being, but a creative work." She also denied that a £120,000 grant from the British Film Institute to fund Particle6 had been used to create Norwood, stating that Norwood had been a self-funded project solely for Xicoia. In late October, businessman Kevin O'Leary, while advocating for the use of AI to replace background actors, stated that they could be replaced with "100 Norwell Tillies" without being able to tell the difference. Ryan Reynolds and a real woman named Natalie "Tilly" Norwood also starred in an advertisement for Mint Mobile's internet service provider Minternet that mocked the character of Norwood. In November 2025, Van der Velden stated in an interview with Deadline that she planned to create 40 further "very diverse" characters alongside Norwood in order to expand the character's "whole universe". Also that month, actress Jameela Jamil criticized the idea of Norwood as "deeply disturbing" for being "a teenage-looking girl who can't say no to a type of sex scene" or "advocate for herself". Van der Velden announced later that month that Particle6 would be producing the History Channel's Streets of the Past, a Dutch documentary series which would be hosted by reality television personality Corjan Mol and would use AI to recreate historical scenes. In March 2026, a music video titled "Take The Lead" featuring Norwood was released on YouTube. It addressed the backlash of Norwood's creation by opening with the lyrics: "When they talk about me, they don't see/ The human spark, the creativity," and, "I'm just a tool, but I've got life." It also featured a disclaimer that says: "made by 18 real humans — from production designers to costume designers to prompters, editors and an actor." The vocals were generated by Suno. == Commentary == Charles Pulliam-Moore of The Verge argued that Norwood's introduction was a stunt to normalize "AI actors" despite Norwood essentially being a digital puppet. Straight Arrow News compared Tilly Norwood to Aki Ross, a CGI character from 2001 that was similarly intended to become a "digital star" and appear in multiple films, while Nicholas Schrivens, writing for The Conversation, likened Norwood to the posthumous use of footage of Carrie Fisher as Princess Leia for Star Wars: The Rise of Skywalker in 2019 and the Los Angeles Times likened Norwood to Hatsune Miku. Scrivens also wrote that "no AI creation has achieved the media cut-through that Tilly has". Moises Mendez II of Out dismissed this as "vapid bullshit", writing, "Nobody wants AI actresses." Scottish actress Briony Monroe alleged that Norwood had been modeled after her likeness and mannerisms, and stated that she was consulting Equity regarding the matter. Musician Stella Hennen said in a viral TikTok video, which was uploaded in October 2025 and featured a side-by-side comparison between herself and Norwood, that Norwood was her "doppleganger". On April 14, 2026, Marie Claire published an article titled "Is Tilly Norwood the Most Dangerous 'Actress' in Hollywood?", though it noted that AI-generated characters are "still not very good at, well, acting," "audiences have not been kind to AI-led productions," and "Norwood's 'performances' have already faced negative reviews as well". The University of Southern California's Entertainment Technology Center's AI media director Yves Bergquist dismissed th

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